To identify biological and phenotypic prognostic markers of recovery vs. persistence of pain and functional disability in adolescents with chronic musculoskeletal pain.
Eligibility
Sex
ALL
Min age
11 Years
Max age
18 Years
Healthy volunteers
Accepted
Inclusion Criteria:
1. The child has a diagnosis of Chronic widespread pain or Chronic primary musculoskeletal pain (other than orofacial) derived from ICD-11 (MG30.0; chronic primary pain is pain in 1 or more anatomic regions that persists for \> 3 months, is associated with significant distress or functional disability and cannot be better explained by another chronic pain condition (e.g., arthritis, lupus)
2. Age between 11-18 years
3. Moderate to Severe Functional Disability (FDI ≥13)
4. English proficiency (reading, speaking)
5. Moderate to severe average pain (VAS ≥30/100)
Exclusion Criteria:
1. Significant cognitive impairment (e.g., severe brain injury)
2. Claustrophobia
3. Significant medical disease (e.g., systemic or central nervous system)
4. Severe psychiatric or neurological conditions (e.g., eating disorder, psychosis)
5. Pregnancy
6. MRI incompatibility (braces, pacemaker)
7. Weight \> 285 lbs.
8. History of \> 1 month opioid treatment.
Primary outcome measure(s)
Pain Intensity and Unpleasantness — 3 months after baseline assessment Pain Intensity and Unpleasantness on visual analogue scale(VAS). VAS scores range from 0 to 100 with higher scores indicating worse pain.
Functional Disability — 3 months after baseline assessment Functional Disability Inventory (FDI) total score. FDI scores range from 0 to 60 with higher scores indicating higher levels of functional disability.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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