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Compound · clinical trials

Bispecific clinical trials

Also listed in trial records as MCLA-129
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 5 trials in our China, USA, Germany, France, Spain, Italy, Netherlands, Belgium, South Korea, Singapore and Japan registers that name Bispecific as an intervention. Synced 29 Sep 2026
5Current trials
2Recruiting now
2Lead sponsors
11Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Bispecific is named as an intervention in 5 current clinical trials in our China, USA, Germany, France, Spain, Italy, Netherlands, Belgium, South Korea, Singapore and Japan registers. 2 are recruiting patients now. The most common phase is Phase 1/2. The sponsor with the most trials is Betta Pharmaceuticals Co., Ltd (4). The most-studied condition is Non-Small Cell Lung Cancer.

Trials by status

  • Recruiting240%
  • Not yet open240%
  • Active, closed120%

Trials by phase

  • Phase 1/2360%
  • Phase 1120%
  • Phase 2120%
01

Clinical trials of Bispecific

5 trials
StudyPhaseStatusLead sponsorRegisters
Study of MCLA-129, a Human Bispecific EGFR and cMet Antibody, in Patients With Advanced NSCLC and Other Solid Tumors
NCT04930432 · ClinicalTrials.gov ↗ · Solid Tumor, Non-Small Cell Lung Cancer, Head and Neck Cancer
Phase 1/2 Recruiting Betta Pharmaceuticals Co., Ltd China, Japan
Study of MCLA-129 in Combination With Ensartinib in Patients With Advanced Solid Tumors.
NCT07448116 · ClinicalTrials.gov ↗ · Solid Advanced Tumor
Phase 1/2 Recruiting Betta Pharmaceuticals Co., Ltd China
Study of MCLA-129 in the Treatment of Advanced Non-small Cell Lung Cancer with AGA and MET Amplification.
NCT06885840 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
Phase 2 Not yet open Betta Pharmaceuticals Co., Ltd China
Study of MCLA-129 Combined With Befotertinib in the Treatment of Advanced Non-small Cell Lung Cancer With EGFR Sensitive Mutation
NCT06015568 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancerใ€EGFR Sensitive Mutation
Phase 1 Not yet open Betta Pharmaceuticals Co., Ltd China
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
NCT04868877 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer Metastatic, Gastric Cancer, Esophageal Squamous Cell Carcinoma
Phase 1/2 Active, closed Merus B.V USA, Germany, France, Spain, Italy, Netherlands, Belgium, South Korea, Singapore

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Bispecific

10 conditions
Non-Small Cell Lung Cancer2Non-Small Cell Lung Cancer Metastatic1Gastric Cancer1Esophageal Squamous Cell Carcinoma1Head and Neck Squamous Cell Carcinoma1Non-Small Cell Lung Cancerใ€EGFR Sensitive Mutation1Solid Advanced Tumor1Solid Tumor1Head and Neck Cancer1Colorectal Cancer1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Betta Pharmaceuticals Co., Ltd4
Merus B.V1
04

By country register

RegisterTrialsRecruiting
Clinical trials in China42
Clinical trials in USA10
Clinical trials in Germany10
Clinical trials in France10
Clinical trials in Spain10
Clinical trials in Italy10
Clinical trials in Netherlands10
Clinical trials in Belgium10
Clinical trials in South Korea10
Clinical trials in Singapore10
Clinical trials in Japan11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Bispecific trials

How many clinical trials are testing Bispecific?

5 current trials in our China, USA, Germany, France, Spain, Italy, Netherlands, Belgium, South Korea, Singapore and Japan registers name Bispecific (also registered as MCLA-129) as a drug or biological intervention, as of the registry sync on 29 September 2026. Completed and withdrawn studies are not counted.

Are Bispecific trials recruiting patients?

Yes. 2 of the 5 trials are recruiting: 2 with sites in China and 1 with sites in Japan. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Bispecific clinical trials?

Betta Pharmaceuticals Co., Ltd (4) and Merus B.V (1). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Bispecific works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Bispecific works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Bispecific (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 29 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.