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Trackers› Clinical trials› Hamilton
Clinical trial register · Canada

Clinical Trials in Hamilton, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Canada and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 6516 matching records held by the registry are in this view. Synced 02 Oct 2026, 03:18 UTC
6516
Studies in scope
all four open statuses
3504
Recruiting now
open to new participants
886
Lead sponsors
across recruiting studies
Top sites
Toronto 2802 Montreal 1898 Vancouver 1176 Calgary 1057 Edmonton 1017
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
McMaster University114 AstraZeneca47 Canadian Cancer Trials Group30 National Cancer Institute (NCI)27 Hamilton Health Sciences Corporation25
Site location
Toronto2802 Montreal1898 Vancouver1176 Calgary1057 Edmonton1017
All 255 locations
Target enrolment
to

Trials with a site in Hamilton

807 of 6516 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Canada
Start
Not yet open
Transition Coaching in Rheumatology
NCT07838896Rheumatic Conditions
McMaster University
Not applicable
86
Hamilton
2027-03
Recruiting
Post-Operative Use of FS2 to Mitigate Scarring in Burn Patients
NCT06807021Burn Scar, Burn Wound
Birch BioMed Inc
Phase 2/3
70
Edmonton, Hamilton
2027-03
Not yet open
Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis
NCT07441408Pulmonary Fibrosis
DrugAdmilparant
Bristol-Myers Squibb
Phase 3
2,380
Sherwood Park, Vancouver, Burlington, Hamilton, Owen Sound, Toronto, Greenfield Park, Montreal
2026-12-16
Not yet open
3-Dimensional Virtual Reality Modelling With Intravascular Indocyanine Green Fluorescence Mapping for Targeted Pulmonary Segmental Resection Trial
NCT06638125Non Small Cell Lung Cancer
St. Joseph's Healthcare Hamilton
Phase 1/2
89
Hamilton
2026-12-01
Not yet open
Functional Mobility and Resistance Exercise for Postmenopausal Females With Type 1 Diabetes
NCT07851662Type 1 Diabetes (T1D), Menopause
Institut de Recherches Cliniques de Montreal
Not applicable
63
Edmonton, Hamilton, Montreal
2026-12
Not yet open
AI-Adaptive AR Training for Balance and Falls Prevention in Older Adults
NCT07781995Older Adults, Older Adults, Balance
McMaster University
Not applicable
30
Hamilton
2026-11-30
Not yet open
SAFE (Self-Administration of Flumist to ImprovE Uptake: A Household-Based Cluster Randomized Trial)
NCT07739719Influenza (Healthy Volunteers)
McMaster University
Phase 4
966
Hamilton
2026-10-15
Not yet open
A Research Study Investigating Denecimig (Mim8) in Adults With Acquired Haemophilia A
NCT07830732Haemophilia A
Novo Nordisk A/S
Phase 3
84
Vancouver, Hamilton, Toronto
2026-10-09
Not yet open
Antireflux Surgery Without Preoperative Esophageal Manometry
NCT07659080GERD, Hiatal Hernia, Heartburn, Paraesophageal Hernia
McMaster University
Not applicable
96
Hamilton
2026-10-01
Recruiting
ACSS Approach on Dysphagia
NCT07533864Anterior Cervical Spine Surgery
Hamilton Health Sciences Corporation
Observational
100
Hamilton
2026-10
Not yet open
A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough
NCT07288528Cough, Refractory Chronic Cough, Unexplained Chronic Cough, Cough Hypersensitivity Syndrome
DrugPregabalin
McMaster University
Phase 4
124
Calgary, Hamilton, London, Québec, Sherbrooke
2026-09-30
Not yet open
Group CBT for Paternal Perinatal Depression
NCT07758036Perinatal Depression, Fathers
McMaster University
Not applicable
112
Hamilton
2026-09-15
Recruiting
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
NCT07623161Myelofibrosis, Anemia
DrugElritercept
Takeda
Phase 3
324
Hamilton, Toronto, Montreal
2026-09-10
Recruiting
A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia
NCT07623200Essential Thrombocythemia
DrugINCA033989
Incyte Corporation
Phase 3
426
Vancouver, Hamilton, Kingston, Toronto, Montreal, Québec
2026-09-08
Recruiting
Head of Bed After Ischemic Stroke Thrombectomy (HoBIT)
NCT07367633Large Vessel Occlusion, Stroke, Ischemic Stroke
Population Health Research Institute
Not applicable
2,240
Greater Sudbury, Hamilton
2026-09-03
Not yet open
Eye Patient Adherence and Compliance Study
NCT07793474Glaucoma Medication Adherence, Glaucoma Patients
St. Joseph's Healthcare Hamilton
Not applicable
189
Hamilton
2026-09-01
Recruiting
Partner4Exercise Study
NCT07408128Cancer
McMaster University
Phase 2/3
183
Hamilton
2026-09-01
Not yet open
Rhythm Psychophysics With Parkinson's Patients
NCT07647913Parkinson Disease(PD)
McMaster University
Not applicable
34
Hamilton
2026-09-01
Not yet open
Totally Robotic Versus Surgeon-Assisted Robotic Lung Resection For Early-Stage NSCLC
NCT06348030Lung Cancer
St. Joseph's Healthcare Hamilton
Not applicable
120
Hamilton
2026-09
Not yet open
Trauma Informed Goal Management Training With a "Support Person" Module for Individuals Impacted by Post-Traumatic Stress
NCT07797543Post Traumatic Stress
McMaster University
Not applicable
64
Hamilton
2026-09
Recruiting
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
NCT07761117Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
DrugElecoglipron
AstraZeneca
Phase 3
6,950
Barrie, Etobicoke, Greater Sudbury, Hamilton, Kingston, London, Markham, Newmarket
2026-08-24
Recruiting
A Study to Evaluate Efficacy, Safety and Tolerability of Remibrutinib in Adult Participants With Severe Chronic Pruritus of Unknown Origin (CPUO)
NCT07700056Chronic Pruritus of Unknown Origin
DrugRemibrutinib
Novartis Pharmaceuticals
Phase 3
180
Hamilton, Québec
2026-08-24
Recruiting
A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus
NCT07776509Obesity or Overweight, Weight-Related Comorbidity, With/Without Diabetes Mellitus, Type 2
DrugLenbelintide
AstraZeneca
Phase 3
500
Calgary, Surrey, Vancouver, Guelph, Hamilton, Stouffville, Toronto, Joliette
2026-08-24
Recruiting
A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight
NCT07784270Obesity or Overweight, Diabetes Mellitus, Type 2
DrugLenbelintide
AstraZeneca
Phase 3
1,500
Calgary, Vancouver, Moncton, Truro, Hamilton, Markham, North York, Sarnia
2026-08-20
Recruiting
A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Laroprovstat, Rosuvastatin and Placebo on LDL-C in LLT-naïve Patients.
NCT07619131Hypercholesterolaemia
DrugsRosuvastatin 1·Rosuvastatin 2
AstraZeneca
Phase 3
600
Hamilton, Scarborough Village, Stouffville, Chicoutimi, Sherbrooke, Victoriaville
2026-08-12
Not yet open
Prevention of Vascular Graft Infection With Hypochlorous Acid
NCT07678632Vascular Prosthetic Graft Infection
Hamilton Health Sciences Corporation
Not applicable
500
Hamilton
2026-08-03
Not yet open
Tirzepatide in the Treatment of Cannabis Use Disorder
NCT07671248Cannabis Use Disorder, Moderate, Cannabis Use Disorder, Severe
DrugTirzepatide
McMaster University
Phase 3
15
Hamilton
2026-08-01
Not yet open
Feasibility of a Community-Integrated Isometric Handgrip Exercise Program and Its Preliminary Effects on Blood Pressure and Cognitive Function in Older Adults
NCT07648498Hypertension, Elevated Blood Pressure
McMaster University
Not applicable
30
Hamilton
2026-07-28
Recruiting
Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment
NCT07444567Asthma, Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilic Syndrome (HES)
DrugsFasenra·Benralizumab
AstraZeneca
Phase 3
230
Calgary, Hamilton, Toronto
2026-07-24
Recruiting
The Influence of Plan B® on Cardiovascular Health.
NCT07759635Female, Premenopausal
DrugLevonorgestrel
McMaster University
Not applicable
40
Hamilton
2026-07-22
By invitation
Neurophysiological Effects of Daily Centrum Use on Mood and Well-Being: A Cognalyzer EEG Analysis in Adults Between 40-60
NCT07740135Well-being/Quality of Life
Zentrela Inc.
Observational
30
Hamilton
2026-07-20
Not yet open
The Creative Team Member: A Study of the Influence of AI Integration Timing on Brainstorming and Ideation
NCT07693803Creativity
McMaster University
Not applicable
16
Hamilton
2026-07-20
Recruiting
An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC
NCT07720284High-risk Muscle Invasive Urothelial Carcinoma
DrugsEnfortumab Vedotin·Rilvegostomig·Dato-DXd·Opdivo
AstraZeneca
Phase 3
915
Calgary, Abbotsford British Columbia, Barrie, Hamilton, Kingston, London, Mississauga, Montreal
2026-07-16
Recruiting
Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study
NCT07673770Dementia, Alzheimer s Disease
McMaster University
Not applicable
30
Hamilton
2026-07-07
Not yet open
Preventing Ovarian Cancer Through Opportunistic Salpingectomy at the Time of Laparoscopic Cholecystectomy
NCT07625137Salpingectomy, Laparoscopic Cholecystectomy
University of British Columbia
Not applicable
240
Langley, Vancouver, Hamilton
2026-07-01
Active, closed
A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight
NCT07662122Obesity, Overweight
DrugBI 3034701
Boehringer Ingelheim
Phase 2
344
Surrey, Victoria, Guelph, Hamilton, London, Stouffville, Toronto, Chicoutimi
2026-06-30
Recruiting
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
NCT07667803Weight Management
DrugElecoglipron
AstraZeneca
Phase 3
4,500
Calgary, Vancouver, Victoria, Moncton, Truro, Brampton, Hamilton, Niagara Falls
2026-06-29
Recruiting
Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma
NCT07555938Multiple Myeloma
DrugsCevostamab·Elotuzumab·Carfilzomib·Pomalidomide
Hoffmann-La Roche
Phase 3
380
Hamilton
2026-06-23
Recruiting
A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity
NCT07595549Obesity, Overweight and/or Obesity, Overweight
DrugBerobenatide
Pfizer
Phase 3
954
Surrey, Moncton, Hamilton, Toronto
2026-06-10
Recruiting
A Study to Evaluate the Efficacy, Safety, Pharmacodynamics (PD), and Pharmacokinetics (PK) of Selnoflast in Reducing Vascular Inflammation in Participants With Atherosclerosis at Risk for Major Adverse Cardiac Events
NCT07448038Atherosclerosis
Genentech, Inc.
Phase 2
162
Hamilton
2026-06-05
Recruiting
Multimodal Intervention to Support Hospital-to-Community Transition in Bipolar Disorder
NCT07213492Bipolar Disorder (BD), Psychosis
McMaster University
Not applicable
10
Hamilton
2026-06-01
Not yet open
Prehabilitation Before Major Surgery
NCT07590141Prehabilitation, Preoperative Care, Elective Surgical Procedures, Postoperative Complications
Queen's University
Not applicable
120
Hamilton, Kingston, Ottawa
2026-06-01
Not yet open
Evaluating the Impact of Psychoeducation and Sleep-informed Workshop Targeting Sleep Concerns in Women and Individuals With Premenstrual Dysphoric Disorder
NCT07554950Sleep Disturbances, PMDD, PMS
St. Joseph's Healthcare Hamilton
Not applicable
72
Hamilton
2026-06
Not yet open
Extended Group Written Exposure Therapy for Comorbid PTSD and BPD (Traits)
NCT07576387Posttraumatic Stress Disorder (PTSD), Borderline Personality Disorder (BPD)
St. Joseph's Healthcare Hamilton
Not applicable
63
Hamilton
2026-06
Not yet open
Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2
NCT07300579Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS), Sepsis, Infection Without Sepsis
Hamilton Health Sciences Corporation
Observational
20,000
Hamilton
2026-06
Recruiting
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis
NCT07577856Colitis, Ulcerative
DrugsJNJ-78934804·Tremfya·Guselkumab
Janssen Research & Development, LLC
Phase 3
644
Edmonton, Vancouver, Kentville, Barrie, Hamilton, London, Toronto, Montreal
2026-05-23
Recruiting
Feasibility and Acceptability of Collecting Sociodemographic Data in CCTG Trials
NCT07390435Cancer
Canadian Cancer Trials Group
Observational
1,000
Calgary, Edmonton, Kelowna, Prince George, Vancouver, Victoria, Saint John, Hamilton
2026-05-15
Recruiting
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
NCT07567001Obesity, Heart Failure
DrugNNC0487-0111
Novo Nordisk A/S
Phase 3
5,610
Calgary, Vancouver, Winnipeg, Moncton, Halifax, Burlington, Courtice, Hamilton
2026-05-11
Recruiting
Study of Recurrence-directed Therapy (RDT) With or Without Androgen-Deprivation Therapy (ADT) In Patients With Radio-recurrent Oligo-metastatic Hormone/Castrate Sensitive Prostate Cancer (romCSPC)
NCT06654336Prostate Adenocarcinoma, Castration Sensitive Prostate Cancer
DrugEligard
Ontario Clinical Oncology Group (OCOG)
Phase 2
162
Hamilton, Ottawa, Montreal
2026-05-06
Recruiting
Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV)
NCT07509151Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated IGHV
DrugSurovatamig
AstraZeneca
Phase 3
420
Calgary, Vancouver, Halifax, Hamilton, Toronto, Montreal, Québec
2026-05-05
Recruiting
Evaluation of the Safety and Efficacy of SALI-10 Probiotic Lozenges
NCT07508839Gingivitis, Halitosis
Ostia Sciences
Not applicable
60
Hamilton
2026-05-04
Recruiting
A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)
NCT07513376Non-small Cell Lung Cancer
DrugsPembrolizumab Formulated with Berahyaluronidase Alfa·Intismeran autogene
Merck Sharp & Dohme LLC
Phase 3
876
Hamilton, Kingston, Montreal
2026-05-04
Recruiting
AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)
NCT07611110Metastatic Castration-resistant Prostate Cancer
DrugsXofigo·FPI-2265·Cabazitaxel·Zytiga
AstraZeneca
Phase 3
670
Edmonton, Halifax, Hamilton, Toronto, Montreal
2026-05-04
Not yet open
Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery
NCT07486505Orthopaedic Fractures, Orthopaedic Trauma Fractures and Non-unions, Orthopaedic Trauma, Orthopaedic Surgery
McMaster University
Not applicable
50
Hamilton
2026-05-01
Recruiting
Falls Validation Study
NCT07536906Intracranial Bleed, Falls
Dr. Kerstin de Wit
Observational
4,000
Hamilton, Kingston, Ottawa, Toronto, Montreal, Québec
2026-05-01
Not yet open
Feasibility of the TransitionED Framework for Youth and Young Adults With Eating Disorders
NCT07518641Eating Disorders in Adolescence, Transition of Care
McMaster University
Not applicable
60
Calgary, Hamilton
2026-05
Recruiting
Guided Self Help for Eating Disorders Implementation Study
NCT06851273Eating Disorders
McMaster University
Not applicable
90
Hamilton
2026-04-28
Recruiting
A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
NCT07499232Crohn Disease
DrugsRisankizumab·Guselkumab
Janssen Research & Development, LLC
Phase 3
530
Edmonton, Vancouver, Hamilton, London, Oshawa, Toronto, Montreal
2026-04-21
Recruiting
Pediatric Evaluation and Registry for Liver Cholestasis in Canada
NCT07411716PFIC - Progressive Familial Intrahepatic Cholestasis, Alagille Syndrome (ALGS), Cholestasis, Intrahepatic
Children's Hospital of Eastern Ontario
Observational
220
Calgary, Edmonton, Vancouver, Winnipeg, St. John's, Halifax, Hamilton, London
2026-04-21
Recruiting
Remibrutinib Open Label Roll-over Post-trial Access Protocol
NCT07456891Indication of the Parent Protocol
DrugRemibrutinib
Novartis Pharmaceuticals
Phase 3
648
Fredericton, Hamilton, London, Québec, Verdun
2026-04-16
Recruiting
PromotIng Optimal Treatment for Community-acquired PNeumonia in EmErgency Rooms
NCT07099976Community-Acquired Pneumonia (CAP), Pneumonia
Jeffrey Pernica
Not applicable
698
Calgary, Edmonton, Vancouver, Hamilton, Ottawa, Toronto
2026-04-15
Recruiting
A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus
NCT07430306Systemic Lupus Erythematosus
DrugAnifrolumab
AstraZeneca
Phase 3
245
Calgary, Richmond, Winnipeg, Hamilton, Toronto
2026-04-13
Recruiting
A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
NCT07481630Obesity, Knee Osteoarthritis (OA)
DrugNNC0487-0111
Novo Nordisk A/S
Phase 3
400
Calgary, Guelph, Hamilton, Trois-Rivières, Québec
2026-04-13
Recruiting
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
NCT07522073Solid Tumors
DrugINCB161734
Incyte Corporation
Phase 3
588
Hamilton, Kingston, Toronto, Montreal, Québec
2026-04-09
Not yet open
The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study
NCT06160947Back Pain
McMaster University
Not applicable
24
Hamilton
2026-04-01
Not yet open
Cognitive Processing Therapy for Childbirth-Related Post-Traumatic Stress Disorder
NCT07495228Childbirth-Related Posttraumatic Stress Disorder, Childbirth-related Trauma
St. Joseph's Healthcare Hamilton
Not applicable
29
Hamilton
2026-04-01
Not yet open
Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anterior Shoulder Dislocation ePisode.
NCT07459777Shoulder Dislocation
McMaster University
Not applicable
30
Hamilton
2026-04-01
Not yet open
Family STEPS: Family Check-Up+
NCT07433361Child Behavior Problem
McMaster University
Not applicable
300
Hamilton
2026-04-01
Not yet open
Using Music During Wound Care Among Seniors With Pressure Injuries
NCT07456618Pressure Injuries, Pressure Injury, Pressure Ulcer (PU)
McMaster University
Not applicable
50
Burlington, Hagersville, Hamilton, Mississauga, North York, Stoney Creek, Strathroy, Toronto
2026-04-01
Not yet open
SHAPE Trial: Skin Health and Allergy Prevention Exposure
NCT07489040Allergy and Immunology
McMaster University
Not applicable
64
Hamilton
2026-04-01
Recruiting
Study of Inhaled ARO-RAGE in Allergen-induced Mild Asthma
NCT07241546Asthma
Arrowhead Pharmaceuticals
Phase 2
36
Vancouver, Calgary, Edmonton, Hamilton, Québec, Saskatoon
2026-03-30
Recruiting
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
NCT07351045Obesity or Overweight
Hoffmann-La Roche
Phase 3
2,000
Calgary, Surrey, Brampton, Hamilton, Sarnia, Trois-Rivières, Québec
2026-03-16
By invitation
Remission Evaluation of Metabolic Interventions in Type 2 Diabetes in Primary Care (REMIT-Prime)
NCT07665567Type 2 Diabetes (T2DM)
McMaster University
Observational
118
Hamilton
2026-03-11
Recruiting
Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training
NCT07445841Stroke
McGill University
Not applicable
120
Hamilton, Laval
2026-03-09
Recruiting
Multiprofen-CC to Reduce Pain in Hand Arthritis
NCT06966206Hand Osteoarthritis
St. Joseph's Healthcare Hamilton
Phase 3
42
Hamilton
2026-03-09
Recruiting
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
NCT07284849CRC (Colorectal Cancer)
DrugsINCA33890·Folfox·Bevacizumab
Incyte Corporation
Phase 3
700
Edmonton, Hamilton, Toronto, Greenfield Park, Lévis, Saskatoon
2026-03-05
Recruiting
Correctional Service of Canada Pilot Trial of Digital Substance Use Disorder Interventions (PROCESS)
NCT07342218Substance Use Disorder (SUD)
St. Joseph's Healthcare Hamilton
Not applicable
20
Brantford, Dundas, Hamilton
2026-02-25
Active, closed
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
NCT07400653Obesity, Overweight and/or Obesity, Overweight, Diabetes, Type 2
DrugBerobenatide
Pfizer
Phase 3
1,078
Etobicoke, Hamilton, Toronto, Mirabel
2026-02-24
Recruiting
Phase 2 EL219 Versus Liposomal Amphotericin B or Voriconazole for Early Antifungal Therapy
NCT07215273Invasive Mould Infection
DrugVoriconazole
Elion Therapeutics, Inc.
Phase 2
60
Hamilton, Toronto
2026-02-13
Recruiting
A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis
NCT07201922Familial Pulmonary Fibrosis, Interstitial Lung Abnormalities, Interstitial Lung Diseases
DrugNerandomilast
Boehringer Ingelheim
Phase 3
80
Hamilton, Montreal
2026-02-10
Recruiting
Evaluation of Food Additive Contributions to Obesity: Pilot Study 1
NCT07437430Obesity (Disorder)
McMaster University
Not applicable
20
Hamilton
2026-02-10
Recruiting
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
NCT07412756Depressive Disorder, Major
DrugBrenipatide
Eli Lilly and Company
Phase 3
1,000
Calgary, Hamilton, Kelowna, Lévis, Montreal, Ottawa, Québec, Richmond
2026-02-09
Recruiting
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
NCT07321886Obesity, Overweight
DrugEloralintide
Eli Lilly and Company
Phase 3
1,980
Brampton, Courtice, Guelph, Hamilton, Québec, Sarnia, Stoney Creek, Trois-Rivières
2026-02-06
Recruiting
A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma
NCT07258511Multiple Myeloma
DrugsRamantamig·Teclistamab
Janssen Research & Development, LLC
Phase 3
400
Calgary, Vancouver, Halifax, Hamilton, London, Toronto, Montreal
2026-02-04
Not yet open
A Brief Cannabis Use Psychoeducation Intervention for Eating Disorder Patients
NCT07387965Eating Disorders, Cannabis Use
St. Joseph's Healthcare Hamilton
Not applicable
80
Hamilton
2026-02-04
Recruiting
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
NCT07322003Amyotrophic Lateral Sclerosis
DrugPridopidine
Prilenia
Phase 3
500
Montreal, Edmonton, Hamilton
2026-02-01
Recruiting
Switching to the IL-23 Inhibitor Guselkumab for People With Active IBD Who Previously Used Ustekinumab (SHIFT-IBD)
NCT07245394Inflammatory Bowel Disease (IBD), Crohn Disease (CD), Ulcerative Colitis (UC), IBD-unclassified (IBD-U)
DrugsTremfya·Guselkumab
TIDHI Innovation Inc.
Observational
200
Calgary, Fredericton, Hamilton, Barrie, Brampton, London, Mississauga, Oakville
2026-01-29
Active, closed
A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight
NCT07357415Obesity, Overweight
DrugRetatrutide
Eli Lilly and Company
Phase 3
600
Brampton, Courtice, Hamilton, Joliette, London, Québec, Sherbrooke, Toronto
2026-01-24
Recruiting
A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
NCT07184944Crohn's Disease
DrugDuvakitug
Sanofi
Phase 3
751
Hamilton, London, New Westminster, Toronto
2026-01-22
Recruiting
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
NCT07277231Chronic Lymphocytic Leukemia
DrugsSonrotoclax·Venclyxto·Acalabrutinib·Venclexta
BeOne Medicines
Phase 3
500
Victoria, Hamilton, Montreal, Québec, Sherbrooke
2026-01-22
Recruiting
Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis
NCT07332091Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis
CSL Behring
Phase 2
84
Calgary, Hamilton, Winnipeg
2026-01-22
Recruiting
A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
NCT07185009Ulcerative Colitis
DrugDuvakitug
Sanofi
Phase 3
751
Toronto, Hamilton
2026-01-16
Recruiting
Vorasidenib Maintenance for IDH Mutant Astrocytoma
NCT06809322IDH-mutant Grade 2 or 3 Astrocytoma
DrugVorasidenib
European Organisation for Research and Treatment of Cancer - EORTC
Phase 3
468
Calgary, Edmonton, Vancouver, Winnipeg, Halifax, Hamilton, Kingston, London
2026-01-16
Recruiting
Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral Anticoagulation
NCT05723926Atrial Fibrillation, Oral Anticoagulation, Stroke, Implant
Javelin Medical
Not applicable
2,000
Hamilton, London
2026-01-09
Not yet open
Assessing Spinal Accessory Nerve Recovery After Post-operative Electrical Stimulation
NCT07074392Head and Neck Cancer, Nerve Injury, Neck Dissection
McMaster University
Not applicable
38
Hamilton
2026-01-01
Recruiting
The Effects of Weight and Nutrition Education on Weight Control Beliefs, Body Image, Self-Esteem and Eating Patterns in Undergraduate Dieters
NCT07349316Dietary Restraint
St. Joseph's Healthcare Hamilton
Not applicable
150
Hamilton
2026-01-01
Not yet open
Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis
NCT07341282Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC)
DrugVancomycin
McMaster University
Phase 2
14
Hamilton
2026-01
Recruiting
AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer
NCT07218809Epithelial Ovarian Cancer
DrugsTorvutatug samrotecan·MIRV·Mirvetuximab Soravtansine·Pegylated liposomal doxorubicin
AstraZeneca
Phase 3
1,100
Edmonton, Hamilton, Kingston, Montreal, Québec
2025-12-29
Active, closed
A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis
NCT07265479Atopic Dermatitis
DrugTapinarof
Organon and Co
Phase 3
187
Calgary, Red Deer, Surrey, Winnipeg, Halifax, Burlington, Hamilton, Niagara Falls
2025-12-29
Active, closed
A Dose-ranging Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Galvokimig in Adult Study Participants With Atopic Dermatitis
NCT07277660Atopic Dermatitis
DrugGalvokimig
UCB Biopharma SRL
Phase 2
165
Edmonton, Hamilton, Toronto, Vancouver
2025-12-29
Recruiting
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
NCT07174336Breast Neoplasms, Neoplasm Metastasis
DrugsTersolisib·Exemestane·Anastrozole·Ribociclib
Eli Lilly and Company
Phase 3
800
Hamilton, Québec, Toronto, Vancouver
2025-12-22
Active, closed
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
NCT07225686Obesity, Obstructive Sleep Apnea
DrugMaridebart cafraglutide
Amgen
Phase 3
250
Calgary, Brampton, Hamilton, Trois-Rivières
2025-12-19
Active, closed
Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
NCT07311850Obesity and Overweight
DrugBerobenatide
Pfizer
Phase 3
3,578
Etobicoke, Hamilton, Toronto, Mirabel
2025-12-19
Recruiting
A Study to Investigate the Efficacy and Safety of Fitusiran Prophylaxis in Male Participants Aged 1 to Less Than 12 Years With Hemophilia A or B
NCT07285460Hemophilia
DrugsAntithrombin·Clotting factor concentrates·Fitusiran
Sanofi
Phase 3
85
Hamilton, Montreal
2025-12-18
Active, closed
Oral Mucositis Management in Patients Receiving Radiation for Head and Neck Cancer: An Evaluation of a Barrier Based Treatment
NCT07697287Squamous Cell Carcinoma, Oropharyngeal Cancers, Nasopharyngeal Cancer, Hypopharyngeal Cancer
McMaster University
Phase 4
29
Hamilton
2025-12-15
Recruiting
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
NCT07218380Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Neoplasm Metastasis
DrugsVepugratinib·Pembrolizumab
Eli Lilly and Company
Phase 3
450
Calgary, Hamilton, Québec, Vancouver
2025-12-12
Recruiting
Real-world Secukinumab Outcomes in Canadian HS Patients
NCT07282015Hidradenitis Suppurativa
Novartis Pharmaceuticals
Observational
142
Calgary, Winnipeg, Fredericton, St. John's, Cobourg, Hamilton, London, Markham
2025-12-12
Recruiting
Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic Cough
NCT06858748Asthma, Chronic Obstructive Pulmonary Disease (COPD), Chronic Cough (CC)
McMaster University
Observational
240
Vancouver, Hamilton, London, Ottawa, Montreal, Québec, Sherbrooke
2025-12-11
Recruiting
Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody
NCT07285213Clostridioides Difficile Infection
AstraZeneca
Phase 2
230
Edmonton, Vancouver, Victoria, Halifax, Hamilton, London, Montreal, Québec
2025-12-10
Recruiting
Intravascular Ultrasound for Peripheral Artery Disease Revascularization
NCT06979284Peripheral Arterial Disease(PAD), Chronic Limb Threatening Ischemia, Intravascular Ultrasound, Major Adverse Limb Events
Hamilton Health Sciences Corporation
Not applicable
772
Montreal, Sherbrooke, Hamilton, Toronto
2025-12-05
Recruiting
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
NCT06937229Alzheimer Disease, Agitation
DrugsKarX-EC·KarXT
Bristol-Myers Squibb
Phase 3
650
Hamilton, London, Toronto, Whitby
2025-12-02
Recruiting
Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates
NCT06849596Neonatal Resuscitation, Apnea Neonatal
Michelle Baczynski
Not applicable
780
Calgary, Edmonton, Vancouver, Hamilton, London, Toronto, Montral, Montreal
2025-12-01
Recruiting
A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
NCT07241390Atherosclerosis Cardiovascular Disease, Chronic Kidney Disease
DrugOrforglipron
Eli Lilly and Company
Phase 3
7,140
Brampton, Cambridge, Chicoutimi, Hamilton, Laval, Moncton, Montreal, Québec
2025-12-01
Not yet open
Hip Fracture Surgery Arterial and Venous Thrombotic Events Prevention
NCT07228663Hip Fracture Surgery, Cardiovascular Prevention, Venous Thromboembolism (VTE)
DrugsDirect Anticoagulant·Dalteparin·DOAC·Tinzaparin
McMaster University
Phase 3
100
Hamilton
2025-12-01
Recruiting
Psychological and Physiological Impact of a Mindfulness-based Intervention on Anxiety Disorders During the Postpartum Period
NCT07262801Postpartum Anxiety, Anxiety Disorders
St. Joseph's Healthcare Hamilton
Not applicable
50
Hamilton
2025-12
Recruiting
Safety and Efficacy of Tarperprumig in Adult Participants With Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis
NCT07160608Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Alexion Pharmaceuticals, Inc.
Phase 2
75
Calgary, Edmonton, Etobicoke, Hamilton, Toronto, Montreal
2025-11-26
Recruiting
Impact of Tildrakizumab on Patient Reported Outcomes in Patients With Moderate-to-severe Psoriasis in Canada
NCT07370766Psoriasis (PsO), Moderate to Severe Psoriasis
Chronicle Academy
Observational
80
Burlington, Hamilton, Kanata, Ottawa, Pickering, Saskatoon
2025-11-25
Active, closed
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy
NCT07226765Obstructive Sleep Apnea
DrugMaridebart cafraglutide
Amgen
Phase 3
250
Calgary, Brampton, Hamilton, Trois-Rivières
2025-11-25
By invitation
Long-term Efficacy and Safety Extension (LTE) Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
NCT07256392Chronic Spontaneous Urticaria
DrugBarzolvolimab
Celldex Therapeutics
Phase 3
1,370
Edmonton, Hamilton, Markham, North Bay, Toronto, Windsor, Québec
2025-11-25
Recruiting
Physiotherapist Navigator Pilot Trial
NCT07045740Cancer
McMaster University
Not applicable
26
Hamilton
2025-11-21
Active, closed
A Study to Learn About How Well BAY 3401016 Works in Adults With Alport Syndrome
NCT07211685Alport Syndrome
Bayer
Phase 2
60
Hamilton, London, Whitby, Montreal, Québec
2025-11-19
Recruiting
AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL
NCT07215585Large B-cell Lymphoma
DrugsR-mini-CHOP·Surovatamig
AstraZeneca
Phase 3
420
Calgary, Victoria, Hamilton, Ottawa
2025-11-11
Recruiting
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
NCT07186101Ulcerative Colitis
DrugsZotemtegrast·Mirikizumab
Eli Lilly and Company
Phase 2
252
Hamilton, London, Mississauga, Trois-Rivières
2025-11-10
Recruiting
Safe Effective Therapy With Low-Dose Glucocorticoid in ANCA-Associated Vasculitis (SAFE-LOW)
NCT06983821Granulomatosis With Polyangiitis, Microscopic Polyangiitis (MPA)
DrugsCytoxan·Prednisone·Rituximab·Cyclophosphamide
Ottawa Hospital Research Institute
Phase 3
36
Hamilton, Ottawa
2025-11-10
Recruiting
Radiation Therapy Followed by Durvalumab (MEDI4736) and Tremelimumab And Surgery Versus Radiation Therapy Followed by Surgery for Resectable Hepatocellular Carcinoma.
NCT07027436Hepatocellular Carcinoma (HCC)
Hamilton Health Sciences Corporation
Phase 3
30
Hamilton, London
2025-11-07
Recruiting
Brivekimig for the Treatment of Moderate to Severe Hidradenitis Suppurativa
NCT07170917Hidradenitis Suppurativa
DrugBrivekimig
Sanofi
Phase 2
208
Edmonton, Kelowna, Hamilton, Toronto, Québec, Sherwood Park
2025-11-06
Active, closed
Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
NCT07220759Overweight, Obesity, Type 2 Diabetes
DrugCagrilintide
Novo Nordisk A/S
Phase 3
330
Kelowna, Moncton, Halifax, Brampton, Hamilton, London, Pointe-Claire, Victoriaville
2025-11-05
Active, closed
Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide
NCT07220642Obesity, Overweight
DrugCagrilintide
Novo Nordisk A/S
Phase 3
300
Moncton, Halifax, Hamilton, London, Oshawa, Toronto, Mirabel
2025-11-05
Recruiting
A Study of Zasocitinib in Adults With Nonsegmental Vitiligo
NCT07108283Nonsegmental Vitiligo
DrugZasocitinib
Takeda
Phase 2
200
Fredericton, Barrie, Hamilton, Oakville, Peterborough, Toronto, Québec, Saskatoon
2025-11-03
Recruiting
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
NCT07291037Non-small Cell Lung Cancer (NSCLC)
DrugsDato-DXd·Docetaxel
AstraZeneca
Phase 3
400
Vancouver, Moncton, Halifax, Brampton, Hamilton, Toronto
2025-10-31
Recruiting
A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation
NCT07217067Atrial Fibrillation
Novartis Pharmaceuticals
Phase 2
165
Calgary, Vancouver, Halifax, Hamilton, London, Newmarket, Toronto, Montreal
2025-10-28
Recruiting
Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression
NCT07250893Depression - Major Depressive Disorder, Childhood Traumas
St. Joseph's Healthcare Hamilton
Not applicable
50
Hamilton
2025-10-25
Recruiting
BoxX-NoAF Clinical Trial
NCT06989775Post Operative Atrial Fibrillation, Atrial Fibrillation, Postoperative
AtriCure, Inc.
Not applicable
960
Hamilton, London, Montreal
2025-10-24
Recruiting
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
NCT07213804Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms, Neoplasm Metastasis
DrugsSofe-M·MIRV·Pegylated liposomal doxorubicin·Topotecan
Eli Lilly and Company
Phase 3
1,630
Calgary, Hamilton, Montreal, Sherbrooke, Surrey, Toronto
2025-10-22
Recruiting
A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma
NCT07219173Asthma
DrugBrenipatide
Eli Lilly and Company
Phase 2
531
Ajax, Calgary, Hamilton, Kelowna, Montreal, Québec, Richmond, Saint-Laurent
2025-10-22
Recruiting
STRIDE (Durvalumab + Tremelimumab) With Lenvatinib vs STRIDE Alone in Unresectable Hepatocellular Carcinoma
NCT06880523Hepatocellular Carcinoma
DrugsSTRIDE (durvalumab·Tremelimumab·Lenvatinib·Durvalumab
Canadian Cancer Trials Group
Phase 2
140
Calgary, Kelowna, Vancouver, Hamilton, Kingston, Kitchener, London, Mississauga
2025-10-21
Recruiting
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
NCT07175428Atrial Fibrillation (AF)
DrugsAmrecibart·Cenvacibart·Apixaban
Regeneron Pharmaceuticals
Phase 2
1,200
Edmonton, Victoria, Moncton, Greater Sudbury, Hamilton, Oshawa, Scarborough Village, Longueuil
2025-10-20
Recruiting
A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
NCT07213609Neoplasms, Colorectal, Neoplasms
GlaxoSmithKline
Phase 1/2
47
Hamilton, Toronto, Montreal
2025-10-20
Recruiting
Magnesium Trial in Acute Asthma in Emergency Department
NCT06785272Asthma
DrugMagnesium sulfate
Suzanne Schuh
Phase 3
192
Calgary, Edmonton, Hamilton, Ottawa, Toronto, Montreal
2025-10-08
Recruiting
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
NCT07184996Ulcerative Colitis
DrugDuvakitug
Sanofi
Phase 3
980
Hamilton, Oakville, Toronto
2025-10-08
Recruiting
Trial of Social Work Services in Fracture Clinic Setting
NCT06973655Orthopaedic Fractures, Socioeconomic Factors
Sheila Sprague
Not applicable
2,000
Hamilton
2025-10-06
Recruiting
Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronary Syndromes
NCT07102628Acute Coronary Syndrome
DrugInclisiran
Novartis Pharmaceuticals
Phase 3
300
Edmonton, Hamilton, London, Newmarket, Montreal, Québec
2025-10-03
Recruiting
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
NCT07207811Transthyretin Amyloid Cardiomyopathy (ATTR CM)
DrugNNC6019-0001
Novo Nordisk A/S
Phase 3
1,280
Calgary, Vancouver, Québec, Halifax, Greater Sudbury, Hamilton, London, Mississauga
2025-10-02
Recruiting
Postprandial Glucose Handing in Contraceptive and IUD Users
NCT07169591Glucose Homeostasis
McMaster University
Observational
54
Hamilton
2025-10-01
Not yet open
Mesenchymal Stromal Cell Therapy to Prevent Bronchopulmonary Dysplasia in Extreme Preterm Infants
NCT07058025Bronchopulmonary Dysplasia (BPD), ELGAN (22-28SA)
Ottawa Hospital Research Institute
Phase 2
168
Edmonton, Hamilton, Ottawa, Toronto, Montreal, Québec
2025-10-01
Recruiting
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
NCT07184931Crohn's Disease
DrugDuvakitug
Sanofi
Phase 3
980
Oakville, Brampton, Edmonton, Greater Sudbury, Hamilton, London, Montreal, New Westminster
2025-10-01
Not yet open
PeerOnCall: Implementing and Evaluating App-Based Peer Support in Canadian Fire Services
NCT07199387Firefighters
McMaster University
Not applicable
2,000
Hamilton
2025-10
Not yet open
Ketamine Sedation in the ICU (KANINE) RCT
NCT06767358Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
DrugKetamine Hydrochloride
McMaster University
Phase 3
54
Hamilton, Toronto
2025-10
Not yet open
Hyivy Device as Non-hormonal Therapy in Endometriosis
NCT05643131Endometriosis, Pelvic Pain
Hyivy Health Inc
Not applicable
20
Hamilton
2025-10
Recruiting
IAMABLE: Implementation and Evaluation of an App for Evidence-Based Self-Management Rehabilitation Strategies
NCT06773169Neurological Conditions, Musculoskeletal Diseases or Conditions, Cardiovascular Diseases
McMaster University
Not applicable
50
Hamilton
2025-09-25
Recruiting
Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation
NCT06942039CNS Embryonal Tumor, CNS, Medulloblastoma, Atypical Teratoid Rhabdoid Tumor, Medulloblastoma, Childhood
DrugsCytarabine IT·Mesna·Filgrastim·Hydrocortisone
C17 Council
Phase EARLY_PHASE1
15
Calgary, Vancouver, Winnipeg, Halifax, Hamilton, London, Montreal, Québec
2025-09-23
Recruiting
Efanesoctocog Alfa Prophylaxis in Patients With Hemophilia A With Synovial Hypertrophy
NCT06941870Factor VIII Deficiency
DrugEfanesoctocog alfa
Sanofi
Phase 4
35
Hamilton
2025-09-23
Recruiting
Power Exercise for Stroke Recovery: The POWER Pilot Trial (POWER-P)
NCT06780995Stroke
McMaster University
Not applicable
60
Kelowna, Hamilton
2025-09-15
Recruiting
A 16-week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream 20 mg/g in Adult Participants With Mild to Severe Palmoplantar Pustulosis
NCT07013201Palmoplantar Pustulosis
DrugDelgocitinib
LEO Pharma
Phase 2
135
Calgary, Edmonton, Surrey, Winnipeg, Fredericton, Hamilton, Markham, Waterloo
2025-09-11
Recruiting
Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes
NCT06840756Red Blood Cell Transfusions, Sex Differences, Health Services, Critically Ill Intensive Care Unit Patients
Michelle Zeller
Phase 4
11,082
Hamilton, Kingston, London, Oshawa, Ottawa, Toronto
2025-09-11
Active, closed
Group Cognitive Behavioural Therapy for Paternal Perinatal Depression
NCT07166237Perinatal Depression, Fathers
McMaster University
Not applicable
48
Hamilton
2025-09-09
Active, closed
Online Transdiagnostic Group CBT for Postpartum Depression and Anxiety
NCT07162129Postpartum Depression (PPD), Postpartum Anxiety
McMaster University
Not applicable
48
Hamilton
2025-09-09
Recruiting
Study to Assess Change in Quality of Life of Risankizumab Treatment in Adult Participants With Moderate-to-Severe Plaque Psoriasis
NCT07039110Plaque Psoriasis
AbbVie
Observational
700
Calgary, Edmonton, Winnipeg, Ajax, Belleville, Hamilton, London, Markham
2025-09-09
Recruiting
Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma
NCT07011719Metastatic Clear Cell Renal Cell Carcinoma, Advanced Clear Cell Renal Cell Carcinoma
DrugsCasdatifan·Cabozantinib
Arcus Biosciences, Inc.
Phase 3
720
Calgary, Edmonton, Hamilton, London, Montreal, Sherbrooke, Toronto, Vancouver
2025-09-08
Recruiting
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
NCT07157774Elevated Lp(a), Atherosclerotic Cardiovascular Disease (ASCVD)
Eli Lilly and Company
Phase 3
10,450
Chicoutimi, Etobicoke, Hamilton, Joliette, Longueuil, Moncton, Montreal, North York
2025-09-02
Recruiting
A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.
NCT06925321Invasive Mold Infections
DrugFosmanogepix
Basilea Pharmaceutica
Phase 3
234
Edmonton, Hamilton, Ottawa, Vancouver
2025-08-26
Recruiting
Deep rTMS for Mild Neurocognitive Disorder in Older Adults
NCT07038798Mild Neurocognitive Disorder
St. Joseph's Healthcare Hamilton
Not applicable
30
Hamilton
2025-08-26
Recruiting
Protease Regulation and Impact of Sodium as Mechanisms of Inflammation in IBD
NCT07169123Crohns Disease
McMaster University
Observational
300
Hamilton
2025-08-18
Active, closed
A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes
NCT07076199Diabetes Mellitus, Type 1
DrugsInsulin aspart·Insulin glargine·Insulin icodec
Novo Nordisk A/S
Phase 3
877
Calgary, Vancouver, Winnipeg, Halifax, Brampton, Etobicoke, Hamilton, London
2025-08-11
Recruiting
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
NCT07114601Breast Neoplasms, Colorectal Neoplasms, Prostate Neoplasm, Endometrial Neoplasms
Eli Lilly and Company
Phase 1
421
Hamilton, Montreal, Toronto
2025-08-06
Recruiting
The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges
NCT07085975Chronic Cough (CC), Asthma
McMaster University
Phase 1
33
Hamilton
2025-08-05
Recruiting
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
NCT07044336Endometrial Cancer, Malignant Solid Tumour
DrugsAdriamycin·Taxol·Doxorubicin·Paclitaxel
AstraZeneca
Phase 3
800
Edmonton, Winnipeg, Hamilton, Kingston, Montreal
2025-08-01
Recruiting
Visible Abdominal Distension
NCT06369753Irritable Bowel Syndrome, Dyspepsia, Functional Bloating
Hospital Universitari Vall d'Hebron Research Institute
Not applicable
100
Hamilton
2025-07-30
Recruiting
Non-invasive Ventilation and Dexmedetomidine in Critically Ill Adults
NCT06259565Non-Invasive Ventilation
DrugDexmedetomidine
St. Joseph's Healthcare Hamilton
Phase 3
846
Surrey, Brockville, Hamilton, Toronto
2025-07-29
Recruiting
The Canadian Lung Outcomes in Users of Vaping Devices Study
NCT06819969Small Airways Diseases, Vaping, Vaping Related Disorder, Vaping Teens
University of British Columbia
Observational
500
Edmonton, Vancouver, Hamilton, Ottawa, Toronto, Sherbrooke
2025-07-25
Active, closed
ORKA-001 Versus Placebo in Patients With Moderate-to-Severe Plaque Psoriasis
NCT07090330Plaque Psoriasis
DrugORKA-001
Oruka Therapeutics, Inc.
Phase 2
80
Edmonton, Surrey, Hamilton, London, Markham, Peterborough, Toronto, Waterloo
2025-07-18
Not yet open
Piloting and Evaluation of a Group Intervention for People With Psychosis Designed to Boost Access and Usage of ICT
NCT07025499Serious Mental Illness
McMaster University
Not applicable
18
Hamilton
2025-07-15
Recruiting
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
NCT07011732Alzheimer Disease
DrugsKarX-EC·KarXT
Bristol-Myers Squibb
Phase 3
426
Hamilton, London, Toronto, Whitby, Montreal
2025-07-10
Active, closed
Investigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy
NCT06908694Prostate Cancer
DrugsSemaglutide Injector·Wegovy
Hamilton Health Sciences Corporation
Phase 4
20
Hamilton
2025-07-02
Recruiting
REhabilitation of MEMory Symptoms After BRain Concussion
NCT06956417Concussion, Brain, Mild Traumatic Brain Injury
University of British Columbia
Not applicable
184
Calgary, Langley, Vancouver, Hamilton, Ottawa, Toronto
2025-07-02
Recruiting
ACB vs no Block for Pediatric ACL Reconstruction
NCT06875427Anterior Cruciate Ligament, Anterior Cruciate Ligament (ACL) Tear
Isabella Jaramillo
Phase 3
38
Hamilton
2025-07-01
Not yet open
Dexmedetomidine Versus Morphine During Cooling Therapy in Neonates
NCT06985290Hypoxic Ischemic Brain Injury, Neonatal Encephalopathy, Perinatal Anoxic-ischemic Brain Injury
DrugsMorphine·Dexmedetomidine
Ipsita Goswami
Phase 2
50
Hamilton
2025-07-01
Not yet open
Reducing Pain in Complex Regional Pain Syndrome Using Personalized Brain Stimulation: A Feasibility Study
NCT06987747Complex Regional Pain Syndrome (CRPS)
McMaster University
Not applicable
10
Hamilton
2025-07-01
Recruiting
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
NCT07082738Chronic Obstructive Pulmonary Disease (COPD)
AstraZeneca
Phase 2
987
Edmonton, Winnipeg, Truro, Ajax, Burlington, Guelph, Hamilton, Stoney Creek
2025-06-27
Recruiting
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
NCT06979362Heart Failure
DrugCDR132L
Novo Nordisk A/S
Phase 2
200
Vancouver, Brampton, Hamilton, Mississauga, Ottawa, Toronto, Winchester, Québec
2025-06-27
Recruiting
The Feasibility of Implementing Syphilis Point-of-care Testing Into a Prenatal Clinic for People Facing Barriers to Care
NCT06829602Syphilis
McMaster University
Not applicable
77
Hamilton
2025-06-25
Active, closed
Safety Study of Viaskin® Peanut Patch in Peanut-Allergic Children 1 Through 3 Years of Age (COMFORT Toddlers)
NCT07003919Allergy, Peanut Allergy
DBV Technologies
Phase 3
480
Winnipeg, Burlington, Hamilton, Ottawa, Toronto, Montreal, Québec
2025-06-24
Recruiting
JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity
NCT06852391Obesity (Disorder)
DrugsSemaglutide Injector·Wegovy
McMaster University
Phase 4
74
Hamilton
2025-06-18
Active, closed
A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children and Adolescents (6 to <18 Years Old) With Moderate Atopic Dermatitis
NCT06832618Atopic Dermatitis
DrugRuxolitinib
Incyte Corporation
Phase 3
159
Calgary, Edmonton, Surrey, Vancouver, Winnipeg, Hamilton, Toronto, Montreal
2025-06-17
Active, closed
Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS2)
NCT06958211Hidradenitis Suppurativa
DrugRuxolitinib
Incyte Corporation
Phase 3
573
Edmonton, Winnipeg, Fredericton, Hamilton, London, Markham, Mississauga, Saskatoon
2025-06-12
Recruiting
Cognitive Groove (Brought to You by GERAS DANCE)
NCT06870149Frailty, Frail Older Adults, Frailty in Aging, Frailty Syndrome
McMaster University
Not applicable
250
Hamilton
2025-06-10
Recruiting
A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)
NCT06852222Leukemia, Myeloid, Acute
DrugsBleximenib·Azacitidine·Venetoclax
Janssen Research & Development, LLC
Phase 3
600
Calgary, Vancouver, Winnipeg, Halifax, Hamilton, London, Toronto, Montreal
2025-06-04
Recruiting
Therapeutic Relevance of Abnormal Airway Morphology in Asthma
NCT06970080Asthma
DrugPrednisone
McMaster University
Phase 4
242
Hamilton, London
2025-06-02
Not yet open
A Trial of Actazin Versus PEG 3350 for Maintenance Therapy in Children With Constipation
NCT06836024Constipation - Functional, Constipation, Constipation Aggravated
DrugPEG 3350
Hamilton Health Sciences Corporation
Phase 2/3
60
Hamilton
2025-06-01
Recruiting
A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)
NCT06124157B Acute Lymphoblastic Leukemia
DrugsCalaspargase Pegol·Tioguanin·Thioguanine·Oncaspar
National Cancer Institute (NCI)
Phase 2
222
Calgary, Edmonton, Vancouver, Winnipeg, Halifax, Hamilton, Toronto, Montreal
2025-05-30
Active, closed
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
NCT07035093Obesity, Overweight, Chronic Low Back Pain (CLBP)
DrugRetatrutide
Eli Lilly and Company
Phase 3
586
Brampton, Hamilton, Sarnia, Sydney, Toronto
2025-05-29
Active, closed
A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event
NCT07000123Cardiovascular Disease
DrugAZD0780
AstraZeneca
Phase 3
3,103
Surrey, Vancouver, Cambridge, Courtice, Guelph, Hamilton, Mississauga, North York
2025-05-28
Recruiting
Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response
NCT06592924Prostate Cancer (Adenocarcinoma)
DrugsApalutamide·Abiraterone·Darolutamide·Enzalutamide
Canadian Cancer Trials Group
Phase 3
830
Edmonton, Vancouver, Winnipeg, Saint John, Greater Sudbury, Hamilton, Kingston, Kitchener
2025-05-28
Recruiting
Sputum Cytometry Guided Management for the Elimination of Chronic Cough in Patients With ILD
NCT05086432ILD
McMaster University
Not applicable
120
Hamilton
2025-05-22
Recruiting
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
NCT06935370Heart Failure
DrugsVicadrostat·Dapagliflozin
Boehringer Ingelheim
Phase 3
4,200
Cambridge, Greater Sudbury, Hamilton, Kitchener, Mississauga, Oakville, Oshawa, Peterborough
2025-05-20
Recruiting
Platform Study to Evaluate the Efficacy and Safety of Investigational Compound(s) in Patients With Moderate to Severe Atopic Dermatitis
NCT06947993Atopic Dermatitis
Novartis Pharmaceuticals
Phase 2
224
Edmonton, Hamilton, Markham, Montreal, Verdun
2025-05-16
Recruiting
Perioperative Durvalumab With Neoadjuvant ddMVAC or Gemcitabine/Cisplatin in Patients With Muscle-invasive Bladder Cancer (NIAGARA-2)
NCT06960577Urinary Bladder Neoplasms, Immune Checkpoint Inhibitors, Methotrexate, Vinblastine
DrugsVinblastine·Methotrexate·Doxorubicin·Durvalumab
AstraZeneca
Phase 3
150
Hamilton, London, Ottawa, Montreal, Québec, Sherbrooke
2025-05-15
Recruiting
A Study of Transcatheter Aortic Valve Replacement Case Selection and Valve Sizing Using the ABC Bicuspid Sizing Algorithm
NCT06991517Aortic Stenosis
World Health Research Inc.
Observational
290
Calgary, Halifax, Hamilton, Newmarket, Ottawa, Toronto, Québec
2025-05-13
Recruiting
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2
NCT07227246Intracerebral Hemorrhage
DrugRecombinant Factor VIIa
Joseph Broderick, MD
Phase 3
350
Calgary, Edmonton, Vancouver, Winnipeg, Hamilton, Ottawa, Toronto, Montreal
2025-05-06
Recruiting
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
NCT06916806Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, Rheumatoid Arthritis
DrugAZD5492
AstraZeneca
Phase 1
72
Hamilton, Sherbrooke
2025-05-01
Recruiting
Role of Anti-TREK-1 Autoantibodies in SCVF
NCT06943365Short-coupled Ventricular Fibrillation, Idiopathic Ventricular Fibrillation
Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Observational
300
Vancouver, Hamilton, Ottawa, Québec
2025-05-01
Recruiting
Comparison of Medical RESCUE Strategies for Patients With Steroid-refractory Acute Severe Ulcerative Colitis
NCT06660693Colitis, Ulcerative
McMaster University
Phase 3
134
Hamilton
2025-04-16
Active, closed
Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)
NCT06814145Hypertension, Pulmonary
DrugSotatercept
Merck Sharp & Dohme LLC
Phase 2
440
Hamilton
2025-04-16
Recruiting
A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)
NCT06401330Stage I Mixed Cell Type Kidney Wilms Tumor, Stage II Mixed Cell Type Kidney Wilms Tumor, Stage III Mixed Cell Type Kidney Wilms Tumor, Stage IV Mixed Cell Type Kidney Wilms Tumor
DrugsDactinomycin·Vincrystine·Cytoxan·Paraplatin
Children's Oncology Group
Phase 3
1,656
Calgary, Edmonton, Winnipeg, Halifax, Hamilton, London, Ottawa, Toronto
2025-04-15
Active, closed
A Study to Assess Efficacy and Safety of JNJ-77242113 Compared to Placebo and Ustekinumab in Participants With Moderate to Severe Plaque Psoriasis
NCT06934226Plaque Psoriasis
DrugsIcotrokinra·Ustekinumab
Janssen Research & Development, LLC
Phase 3
752
St. John's, Ajax, Barrie, Hamilton, London, Markham, Waterloo, Montreal
2025-04-15
Recruiting
Biomarkers in Patients With Anemia-Induced Thrombocytopenic Bleeding
NCT06947044Acute Leukemia, Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukaemia
Donald Arnold
Not applicable
60
Hamilton
2025-04-11
Recruiting
A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors
NCT06846671CLL, Chronic Lymphocytic Leukemia
DrugsIdelalisib·Tacabrutideg·Bendamustine·Venetoclax
BeOne Medicines
Phase 3
250
Hamilton, London, Ottawa, Greenfield Park, Montreal, SaintJerome
2025-04-10
Recruiting
LND101 for Fecal Microbiota Transplantation in Combination With Immune Checkpoint Blockade in Advanced Melanoma
NCT06623461Melanoma
Canadian Cancer Trials Group
Phase 2
128
Abbotsford British Columbia, Surrey, Vancouver, Hamilton, London, Newmarket, Ottawa, Toronto
2025-04-07
Recruiting
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
NCT06665165ALS
Amylyx Pharmaceuticals Inc.
Phase 1
48
Calgary, Hamilton, London, Montreal
2025-04-07
Recruiting
Feasibility of a Diet Intervention for Juvenile Arthritis
NCT06474546Arthritis, Juvenile, Arthritis, Childhood, Juvenile Idiopathic Arthritis
The Hospital for Sick Children
Not applicable
54
Winnipeg, Hamilton, London, Ottawa, Toronto, Montreal, Saskatoon
2025-04-07
Recruiting
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
NCT06801834Extensive Stage Small Cell Lung Cancer (ES-SCLC)
DrugsAmrubicin·Lurbinectedin·Topotecan·Sacituzumab Govitecan
Gilead Sciences
Phase 3
695
Barrie, Hamilton, Montreal, Rimouski, Toronto
2025-04-04
Recruiting
Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure
NCT06957366Atrial Fibrillation (AF), VTE
McMaster University
Not applicable
920
Winnipeg, Hamilton, Ottawa, Toronto
2025-04-01
Recruiting
The Dragon PLC Trial (DRAGON-PLC)
NCT06914648Primary Liver Cancer, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
Maastricht University
Not applicable
358
Calgary, Vancouver, Halifax, Hamilton, Kingston, London, Toronto, Sherbrooke
2025-04-01
Recruiting
IM Screw vs. K-wire Fixation of Proximal/Middle Phalanx Fractures
NCT06372067Hand; Fracture, Phalanx
McMaster University
Not applicable
34
Hamilton
2025-04-01
Recruiting
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
NCT06897475Type 2 Diabetes
Eli Lilly and Company
Phase 2
200
Brampton, Chicoutimi, Hamilton, Longueuil, Moncton, Sarnia, Toronto, Waterloo
2025-03-28
Recruiting
Outpatient and Intermittent Dosing of Elranatamab in Relapsed/Refractory Multiple Myeloma
NCT06421675Refractory Multiple Myeloma
DrugElranatamab
Ontario Clinical Oncology Group (OCOG)
Phase 2
40
Vancouver, Victoria, Hamilton, Kingston, London, Ottawa
2025-03-28
Recruiting
A Trial of a Next Generation COVID-19 Vaccine Delivered by Inhaled Aerosol
NCT06381739COVID-19 Infection
McMaster University
Phase 2
350
Halifax, Hamilton
2025-03-25
Recruiting
Canadian Critical Care Comparative Effectiveness Platform
NCT06605144Intensive Care Unit ICU, Vasopressor, Platelet, Nutrition
Université de Sherbrooke
Phase 3
5,500
Moncton, Hamilton, Ottawa, Scarborough Village, St. Catharines, Toronto, Montreal, Sherbrooke
2025-03-23
Recruiting
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy
NCT06174220Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy
DrugTideglusib
Hamilton Health Sciences Corporation
Phase 2
120
Calgary, Vancouver, Victoria, St. John's, Halifax, Hamilton, Kingston, London
2025-03-21
Active, closed
Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept Study
NCT06225232Cannabis Use Disorder, Moderate, Cannabis Use Disorder, Severe
DrugsPsychotherapy·Psilocybin
McMaster University
Phase 2
16
Hamilton
2025-03-21
Active, closed
Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
NCT06858878Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight
DrugMaridebart cafraglutide
Amgen
Phase 3
1,105
Surrey, Winnipeg, Halifax, Brampton, Concord, Hamilton, London, Nepean
2025-03-17
Recruiting
Technology-Enabled Collaborative Care for Diabetes and Mental Health
NCT07181863Type 2 Diabetes, Mental Health, Diabetes Distress
McMaster University
Not applicable
160
Hamilton
2025-03-16
Recruiting
Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke and Direct Oral Anticoagulants Intake
NCT06571149Ischemic Stroke
DrugsAlteplase·Tenecteplase
Insel Gruppe AG, University Hospital Bern
Phase 4
906
Hamilton
2025-03-14
Active, closed
Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
NCT06858839Obesity
DrugMaridebart cafraglutide
Amgen
Phase 3
3,853
Surrey, Hamilton, North York, Oshawa, Scarborough Village, Thunder Bay, Toronto, Chicoutimi
2025-03-12
Recruiting
A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)
NCT06615479Relapsed or Refractory Multiple Myeloma (RRMM)
DrugsArlo-cel·Carfilzomib·Pomalidomide·Daratumumab
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
Phase 3
440
Calgary, Vancouver, Halifax, Hamilton, Montreal
2025-03-12
Recruiting
Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy for Painful Non-Spine Bone Metastases
NCT06391242Cancer Metastatic
Canadian Cancer Trials Group
Phase 3
230
Calgary, Vancouver, Hamilton, Kingston, London, Newmarket, Toronto, Montreal
2025-03-07
Active, closed
A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
NCT06859268Obesity
DrugRetatrutide
Eli Lilly and Company
Phase 3
643
Brampton, Burlington, Courtice, Hamilton, Terrebonne, Thunder Bay, Toronto, Trois-Rivières
2025-03-05
Recruiting
Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions
NCT07699159Multiple Mental Health Conditions, Child Mental Health, Youth Mental Health
Centre for Addiction and Mental Health
Observational
1,620
Calgary, Hamilton, Ottawa, Toronto
2025-03-04
Recruiting
SCORE! ACTIVE Trial
NCT06844786Chronic Disease, Childhood Obesity
Hamilton Health Sciences Corporation
Not applicable
1,400
Hamilton
2025-03-01
By invitation
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0
NCT06823115Acute Kidney Injury, Fluid Overload, Prematurity Complications, Risk Factors
Indiana University
Observational
4,000
Toronto, Calgary, Edmonton, Hamilton, Montreal
2025-03-01
Recruiting
A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer
NCT06764875HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
DrugsRilvegostomig·Trastuzumab deruxtecan·Trastuzumab·Adrucil
AstraZeneca
Phase 3
840
Calgary, Edmonton, Winnipeg, Barrie, Brampton, Hamilton, Toronto, Chicoutimi
2025-03-01
Not yet open
Β-OHB Supplementation and Brain Health in Older Adults
NCT06588946Subjective Cognitive Decline
McMaster University
Phase 2
48
Hamilton
2025-03
Recruiting
Health Literacy in Geriatric Patients
NCT06971393Health Literacy
Hamilton Health Sciences Corporation
Observational
100
Hamilton
2025-02-26
Recruiting
Kinematic and Mechanical Alignment Randomized Trial
NCT06787417Total Knee Arthroplasty, Osteoarthritis
McMaster University
Phase 4
260
Hamilton
2025-02-20
Active, closed
A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity
NCT06780449Obesity
DrugsCagrilintide·Semaglutide
Novo Nordisk A/S
Phase 3
400
Victoria, Halifax, Hamilton, Québec
2025-02-10
Recruiting
EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma
NCT06556563Glioblastoma
DrugsTemozolomide·Keytruda·Pembrolizumab
NovoCure GmbH
Phase 3
741
Edmonton, Hamilton, Ottawa, Toronto, Montreal, Sherbrooke
2025-02-03
Recruiting
Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer
NCT06888388Breast Cancer Surgery
Sir Mortimer B. Davis - Jewish General Hospital
Observational
4,700
Calgary, Hamilton, Toronto, Montreal, Québec
2025-02-01
Recruiting
Do QT-Prolonging Drugs Cause Major Adverse Cardiac Events in Hospitalized Adults?
NCT07374263Acquired Long QT, Ventricular Arrhythmias, Torsades de Pointes, Syncope
St. Joseph's Healthcare Hamilton
Observational
990,000
Hamilton, Toronto
2025-02-01
Active, closed
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa (RECHARGE 1)
NCT06799000Hidradenitis Suppurativa
DrugRemibrutinib
Novartis Pharmaceuticals
Phase 3
588
Surrey, St. John's, Hamilton, Richmond Hill, Québec, Saint-Jérôme
2025-01-31
Recruiting
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
NCT06717347Diffuse Large B-Cell Lymphoma
DrugsRituximab Biosimilar·Zilovertamab vedotin·Riabni·Ruxience
Merck Sharp & Dohme LLC
Phase 3
1,046
Edmonton, Halifax, Hamilton, Oshawa, Toronto
2025-01-27
Recruiting
A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
NCT06585774Chronic Graft-versus-host-disease
DrugsAxatilimab·Methylprednisolone·Prednisolone·Prednisone
Incyte Corporation
Phase 3
240
Calgary, Edmonton, Vancouver, Halifax, Hamilton, Toronto, Montreal
2025-01-21
Recruiting
The Development, Safety, and Feasibility of an Artificial Intelligence-Powered Platform (NodeAI) for Real-Time Prediction of Mediastinal Lymph Node Malignancy During Endobronchial Ultrasound Staging for Lung Cancer
NCT06540196Lung Cancer, Non Small Cell Lung Cancer
McMaster University
Not applicable
600
Hamilton
2025-01-10
Active, closed
Long-term Safety and Efficacy of ESK-001 in Moderate to Severe Plaque Psoriasis
NCT06846541Plaque Psoriasis, Psoriasis (PsO), Psoriasis, Moderate Psoriasis
Alumis Inc
Phase 3
1,680
Edmonton, Red Deer, Surrey, Ajax, Barrie, Coburg, Guelph, Hamilton
2025-01-08
Recruiting
International Care Bundle Evaluation in Cerebral Hemorrhage Research
NCT06429332Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage, Stroke
Region Skane
Phase 4
3,500
Greater Sudbury, Hamilton, Ottawa
2025-01-07
Recruiting
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease
NCT06227910Crohn's Disease
DrugsVedolizumab·Upadacitinib
Takeda
Phase 3
396
Calgary, Winnipeg, Halifax, Barrie, Hamilton, Oshawa, Toronto, Vaughan
2025-01-02
Not yet open
Supplementation for Male Subfertility
NCT06091969Male Infertility
Hamilton Health Sciences Corporation
Phase 2
64
Hamilton
2025-01-01
Not yet open
Repetitive Transcranial Magnetic Stimulation Paired with Augmented Reality to Alter Concussion Symptoms
NCT06735157Mild Traumatic Brain Injury, Concussion, Chronic Dizziness, Vestibular Problem
McMaster University
Not applicable
40
Hamilton
2025-01-01
Not yet open
Ketorolac Versus Corticosteroid Injections for Sacroiliac Joint Pain
NCT06081101Sacro-iliac Joint Pain
DrugsKetorolac·Methylprednisolone
McMaster University
Phase EARLY_PHASE1
20
Hamilton
2025-01
Recruiting
Predictors of Relapse in Major Depressive Disorder (PERFORM-D)
NCT06746155Major Depressive Disorder (MDD)
Abraham Nunes
Observational
252
Calgary, Vancouver, Halifax, Hamilton, Kingston, Ottawa, Toronto, Whitby
2024-12-27
Active, closed
Polycystic Kidney Disease 1 (PKD1) Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease
NCT06747572Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Vertex Pharmaceuticals Incorporated
Observational
401
Hamilton, Montreal
2024-12-19
Recruiting
Belimumab in Autoimmune Hepatitis
NCT06381453Autoimmune Hepatitis
DrugBelimumab
University Health Network, Toronto
Phase 2
48
Calgary, Vancouver, Hamilton, London, Toronto
2024-12-11
Recruiting
STRatIfication of Vulvar SCC by HPV and p53 Status to Guide Excision
NCT06358469Vulvar Squamous Cell Carcinoma
Canadian Cancer Trials Group
Not applicable
249
Kelowna, Vancouver, Victoria, Hamilton, Toronto, Montreal, Québec, Sherbrooke
2024-12-10
Recruiting
The Effect of Retrograde Autologous Priming on Transfusion Requirements After Cardiac Surgery
NCT06230198Red Blood Cell Transfusion
Population Health Research Institute
Not applicable
4,500
Winnipeg, Hamilton, Montreal
2024-12-04
Active, closed
A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab
NCT06706817Chronic Rhinosinusitis With Nasal Polyps
AstraZeneca
Phase 3
181
Hamilton, Québec
2024-12-03
Recruiting
Longitudinal Study on Bacterial Production of LPC and LPA in Patients With Inflammatory Bowel Disease
NCT06548399Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis
McMaster University
Observational
15
Hamilton
2024-12-01
Recruiting
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Non-Squamous NSCLC
NCT06627647Non-squamous Non-small Cell Lung Cancer
DrugsRilvegostomig·Pemetrexed·Keytruda·Cisplatin
AstraZeneca
Phase 3
1,160
Abbotsford British Columbia, Saint John, Sydney, Greater Sudbury, Hamilton, Kingston, Sault Ste. Marie, Montreal
2024-11-27
Recruiting
Postop Pain Management in Pituitary Tumour Patients
NCT06353529Pituitary, Pain, Postoperative
Hamilton Health Sciences Corporation
Phase 4
108
Hamilton
2024-11-25
Recruiting
Investigating the Role of ATP Production by Airway Epithelium in Patients With Refractory and Unexplained Chronic Cough (RCC/UCC).
NCT06600646Chronic Cough (CC)
McMaster University
Observational
30
Hamilton
2024-11-22
Recruiting
International CRDS Registry
NCT06508164Calcium Release Deficiency Syndrome
Population Health Research Institute
Observational
500
Calgary, Edmonton, Vancouver, Hamilton, London, Ottawa, Montreal, Québec
2024-11-21
Recruiting
Timing of TAP Blocks in Bariatric Surgery
NCT06270147Opioid Use, Pain, Postoperative
McMaster University
Phase 2
100
Hamilton
2024-11-21
Not yet open
SCORE! Non-Physician Health Worker (NPHW) Implementation Protocol (SIP)
NCT06694987Hypertension, Diabetes Mellitus, Dyslipidemia, Metabolic Syndrome
Sonia Anand
Not applicable
137
Hamilton
2024-11-20
Recruiting
Analytical Validation of Stream™ Platform
NCT06541431Gastrointestinal Diseases
FluidAI Medical
Observational
50
Hamilton
2024-11-19
Recruiting
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)
NCT06692738Non-small Cell Lung Cancer
DrugsRilvegostomig·Nab-paclitaxel·Keytruda·Paclitaxel
AstraZeneca
Phase 3
1,160
Saint John, Sydney, Greater Sudbury, Hamilton, Sault Ste. Marie, Montreal
2024-11-18
Recruiting
Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia
NCT06637332Staphylococcus Aureus Septicemia, Staphylococcus Aureus Bacteremia, S. Aureus Bacteremia, S. Aureus Bloodstream Infection
DrugsDaptomycin·Vancomycin
Todd C. Lee MD MPH FIDSA
Phase 4
300
Edmonton, Surrey, St. John's, Hamilton, Toronto, Montreal
2024-11-14
Recruiting
LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)
NCT06446739Acute Kidney Injury, Dialysis; Complications
University of Alberta
Not applicable
100
Calgary, Edmonton, St. Albert, Hamilton, North York, Toronto, Regina
2024-11-14
By invitation
Long-term Follow up of the Stability 1 Trial
NCT06885372LET, ACL Reconstruction, Osteoarthritis (OA) of the Knee
Western University, Canada
Not applicable
510
Banff, Calgary, New Westminster, Winnipeg, Hamilton, Kingston, London
2024-11-01
Not yet open
The Effects of Metformin on Morbidity and Mortality in Elderly Patients
NCT04530058Burns
DrugMetformin
Hamilton Health Sciences Corporation
Phase 2
250
Hamilton
2024-11
Recruiting
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
NCT06368817Basal Ganglia Germinoma, Diabetes Insipidus, Germinoma, Pineal Region Germinoma
DrugsParaplatin·Etoposide·Carboplatin
Children's Oncology Group
Phase 2
240
Edmonton, Vancouver, Winnipeg, Halifax, Hamilton, London, Toronto, Montreal
2024-10-22
Recruiting
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
NCT06623422Carcinoma, Non-Small-Cell Lung
DrugsIntismeran autogene·Paraplatin·Taxol·Pemetrexed
Merck Sharp & Dohme LLC
Phase 3
680
Halifax, Hamilton, Kingston, Oshawa, Toronto, Montreal, Québec
2024-10-21
Recruiting
Pericardiotomy in Cardiac Surgery
NCT06486636Atrial Fibrillation, Atrial Flutter, Cardiac Events
Population Health Research Institute
Not applicable
1,400
Hamilton
2024-10-21
Recruiting
Transcranial Direct Current Stimulation and Yoga for Knee Osteoarthritis
NCT06228573Knee Osteoarthritis
McMaster University
Not applicable
68
Hamilton, London, Sherbrooke
2024-10-20
Recruiting
DETECTion of PeriOperative Atrial Fibrillation After Noncardiac Surgery
NCT06519747Atrial Fibrillation, Atrial Flutter
Population Health Research Institute
Observational
750
Hamilton, London, St. Catharines, Sherbrooke
2024-10-15
Recruiting
Post Discharge After Surgery Virtual Care with Remote Automated Monitoring Technology-2 (PVC-RAM-2) Trial
NCT04876950Surgery, Perioperative Complication
Population Health Research Institute
Not applicable
2,000
Hamilton
2024-10-04
Recruiting
NoNO-42 Trial in Acute Ischemic Stroke Patients Selected for Thrombolysis With or Without Endovascular Thrombectomy
NCT06403267Acute Ischemic Stroke
DrugNoNO-42
NoNO Inc.
Phase 2
600
Calgary, Edmonton, Vancouver, Winnipeg, Hamilton, Ottawa, Toronto, Saskatoon
2024-10-02
Recruiting
EMG Biofeedback Training to Improve Balance in Individuals with Multiple Sclerosis
NCT06461741Multiple Sclerosis
McMaster University
Not applicable
46
Hamilton
2024-10-01
Recruiting
Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer
NCT06510374Intermediate Risk Non-Muscle Invasive Bladder Cancer
DrugNadofaragene Firadenovec
Ferring Pharmaceuticals
Phase 3
454
Calgary, Burlington, Hamilton, Toronto
2024-10-01
Recruiting
A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer
NCT06545955Non-muscle Invasive Bladder Cancer With Carcinoma in Situ
DrugsNadofaragene Firadenovec·Docetaxel·Gemcitabine·Pembrolizumab
Ferring Pharmaceuticals
Phase 3
250
Calgary, Hamilton, Toronto, Montreal
2024-10-01
By invitation
Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma
NCT06609239Asthma
DrugLunsekimig
Sanofi
Phase 2
900
Ajax, Hamilton, Sherbrooke, Trois-Rivières
2024-09-30
Recruiting
A Study of GSK5764227 in Participants With Advanced Solid Tumors (EMBOLD)
NCT06551142Neoplasms
DrugsRis-Rez·Tarlatamab·Dostarlimab·Cetuximab
GlaxoSmithKline
Phase 1
845
Hamilton, Ottawa, Toronto, Montreal, Sherbrooke
2024-09-30
Active, closed
Study to Assess the Efficacy, Safety, and Tolerability of NOC-110 in Adults With Refractory or Unexplained Chronic Cough
NCT06504446Refractory or Unexplained Chronic Cough
Nocion Therapeutics
Phase 2
455
Ajax, Burlington, Hamilton, Toronto, Montreal, Québec, Saint-Charles-Borromée, Sherbrooke
2024-09-24
Recruiting
All Providers Better Communication Skills Program' (ABCs)
NCT06606470Education of Primary Care Clinicians, Palliative Care, Communication
McMaster University
Not applicable
350
Hamilton
2024-09-23
Active, closed
Public Health Nurse-Peer Co-Led Group Cognitive Behavioral Therapy for Postpartum Depression
NCT06597448Postpartum Depression
McMaster University
Not applicable
170
Hamilton
2024-09-16
Recruiting
Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
NCT06081348Neurodevelopmental Disorders, Autism, Autism Spectrum Disorder, Fragile X Syndrome
DrugsZoloft·Sertraline
Holland Bloorview Kids Rehabilitation Hospital
Phase 2
130
Calgary, Edmonton, Halifax, Hamilton, Kingston, London, Toronto
2024-09-16
Recruiting
Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)
NCT05554393Acute Myeloid Leukemia
DrugsDaunorubicin·Cytarabine·Azacitidine·Venetoclax
National Cancer Institute (NCI)
Phase 2
153
Calgary, Edmonton, Winnipeg, Halifax, Hamilton, Toronto, Greenfield Park, Montreal
2024-09-13
Recruiting
M3-JIA: Making Mindfulness Matter for Children With JIA
NCT06376149Juvenile Idiopathic Arthritis, Children, Mental Health, Mental Well-being
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Not applicable
74
Hamilton, London, Toronto
2024-09-12
Recruiting
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas
NCT06422806Metastatic Dedifferentiated Liposarcoma, Metastatic Undifferentiated Pleomorphic Sarcoma, Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
DrugsDoxorubicin·Keytruda·Pembrolizumab
National Cancer Institute (NCI)
Phase 3
365
Calgary, Edmonton, Vancouver, Winnipeg, Hamilton, Ottawa, Toronto, Québec
2024-09-11
Recruiting
A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
NCT06379789Hemophilia B
Regeneron Pharmaceuticals
Phase 1/2
130
Edmonton, Hamilton, Montreal
2024-09-11
Active, closed
Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)
NCT06564142Immunoglobulin A Nephropathy
DrugPovetacicept
Alpine Immune Sciences Inc, A Subsidiary of Vertex
Phase 3
605
Hamilton
2024-08-30
Recruiting
AIRE-2 Device for Study of Breath Analysis in IBD
NCT06541938Inflammatory Bowel Diseases
McMaster University
Not applicable
60
Hamilton
2024-08-28
Recruiting
A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis
NCT06461897Atopic Dermatitis
DrugsUpadacitinib·Dupilumab
AbbVie
Phase 3
675
Calgary, Edmonton, Vancouver, Halifax, Hamilton, Markham, Niagara Falls, Toronto
2024-08-19
Recruiting
A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
NCT06549595Untreated Follicular Lymphoma
DrugsSurovatamig·R-Chop
AstraZeneca
Phase 3
1,018
Winnipeg, Halifax, Barrie, Hamilton, Oshawa, Toronto, Chicoutimi, Montreal
2024-08-07
Active, closed
A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)
NCT06459180Cervical Cancer
DrugsTisotumab Vedotin·Vinorelbine·Topotecan·Sacituzumab tirumotecan
Merck Sharp & Dohme LLC
Phase 3
686
Kelowna, Surrey, Victoria, Barrie, Hamilton, Montreal, Québec
2024-07-24
Recruiting
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
NCT06979323Asthma
DrugDepemokimab
GlaxoSmithKline
Phase 3
150
Ajax, Hamilton, London
2024-07-19
Active, closed
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)
NCT06455202Chronic Spontaneous Urticaria
DrugBarzolvolimab
Celldex Therapeutics
Phase 3
976
Edmonton, Hamilton, London, North Bay, Ottawa, Richmond Hill, Toronto, Windsor
2024-07-19
Recruiting
Early Diagnosis and Treatment of Undiagnosed Asthma or COPD: THE UCAP 2 TRIAL
NCT06392776COPD, Asthma
Ottawa Hospital Research Institute
Not applicable
420
Hamilton, Kingston, Ottawa, Toronto, Québec, Saskatoon
2024-07-16
Active, closed
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
NCT06445023Chronic Spontaneous Urticaria
DrugBarzolvolimab
Celldex Therapeutics
Phase 3
963
Edmonton, St. John's, Hamilton, Markham, Richmond Hill, Toronto, Calgary
2024-07-11
Recruiting
Precision Dosing of Oral Ibuprofen for PDA, A Pilot RCT
NCT07143201Patent Ductus Arteriosus, Preterm
Hamilton Health Sciences Corporation
Phase 2
26
Hamilton
2024-07-04
Recruiting
Affect of Duavive on Mood & Anxiety Symptoms
NCT04478305Menopause, Depression, Anxiety, Sleep, Menopause Related Conditions
St. Joseph's Healthcare Hamilton
Phase 1
30
Hamilton
2024-07-03
Active, closed
Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease
NCT06293365Sjögrens Disease, Systemic Lupus Erythematosus, Rheumatoid Arthritis
DrugIanalumab
Novartis Pharmaceuticals
Phase 2
155
Hamilton, Toronto, Rimouski, Trois-Rivières
2024-07-02
Active, closed
A Phase III Study to Investigate the Efficacy and Safety of Anifrolumab in Adults With Chronic and/or Subacute Cutaneous Lupus Erythematosus
NCT06015737Cutaneous Lupus Erythematosus
AstraZeneca
Phase 3
339
Vancouver, Hamilton, Toronto
2024-06-29
Active, closed
A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
NCT06468228Hidradenitis Suppurativa
DrugLutikizumab
AbbVie
Phase 3
1,400
Calgary, Edmonton, Kelowna, Fredericton, St. John's, Cobourg, Hamilton, London
2024-06-27
Recruiting
Development of a Novel Endoscopic Index and Patient-reported Outcome Measure for Clinical Trials in Participants With Permanent Ileostomy
NCT06670638Crohns Disease
Alimentiv Inc.
Observational
50
Hamilton, London
2024-06-19
Active, closed
The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care
NCT04947722Fracture, Fractures, Hip, Osteoporosis
McMaster University
Not applicable
3,060
Hamilton
2024-06-19
Recruiting
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
NCT05564390Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm, Acute Myeloid Leukemia Post Cytotoxic Therapy, Acute Myeloid Leukemia, Myelodysplasia-Related
DrugsEmavusertib·Olutasidenib·Vyxeos·Mylotarg
National Cancer Institute (NCI)
Phase 2
2,000
Calgary, Edmonton, Winnipeg, Halifax, Hamilton, Ottawa, Toronto, Greenfield Park
2024-06-18
Recruiting
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
NCT06424288Heart Failure
DrugsVicadrostat·Dapagliflozin
Boehringer Ingelheim
Phase 3
6,712
Cambridge, Hamilton, Mississauga, Oakville, Oshawa, Peterborough, Sarnia, Stoney Creek
2024-06-17
Recruiting
Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients Pilot Trial
NCT05841056Atrial Fibrillation New Onset
DrugAmiodarone Hydrochloride
Population Health Research Institute
Phase 3
400
Hamilton, Toronto
2024-06-13
Recruiting
A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children and Infants With Moderate-to-severe Atopic Dermatitis
NCT06311682Atopic Dermatitis
DrugTralokinumab
LEO Pharma
Phase 3
195
Burlington, Calgary, Edmonton, Hamilton, Niagara Falls, Saskatoon, Windsor, Winnipeg
2024-06-10
Recruiting
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
NCT06439277Obesity, Weight Gain
DrugTirzepatide
Eli Lilly and Company
Phase 3
300
Hamilton, Sarnia
2024-06-03
Recruiting
A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)
NCT06345729Non-small Cell Lung Cancer
DrugsCalderasib·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
600
Winnipeg, Halifax, Hamilton, Toronto, Montreal, Trois-Rivières
2024-05-24
Active, closed
Albumin Utilization in Adult Cardiac Surgical Patients: Retrospective
NCT06322537Cardiovascular Surgical Procedures, Albumin
University Health Network, Toronto
Observational
505
New Westminster, Vancouver, Halifax, Hamilton, Kingston, London, Ottawa, Toronto
2024-05-23
Recruiting
Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer
NCT06343402Non-small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer, NSCLC, KRAS G12C
DrugsBBO-10203·Pembrolizumab
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
Phase 1
350
Edmonton, Hamilton, Toronto, Montreal
2024-05-22
Recruiting
VE303 for Prevention of Recurrent Clostridioides Difficile Infection
NCT06237452Clostridium Difficile, Clostridium Difficile Infections, Clostridium Difficile Infection Recurrence, Clostridioides Difficile Infection
Vedanta Biosciences, Inc.
Phase 3
852
Calgary, Edmonton, Red Deer, Vancouver, Moncton, St. John's, Hamilton, London
2024-05-20
Recruiting
Combination Cefazolin With Ertapenem for Methicillin-susceptible Staphylococcus Aureus Bacteremia
NCT04886284Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia, Staphylococcal Sepsis, Staphylococcus Aureus Endocarditis
DrugErtapenem
Todd C. Lee MD MPH FIDSA
Phase 2
60
Calgary, Surrey, Hamilton, Saint Catharines, Laval, Montreal
2024-05-20
Active, closed
A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy
NCT06393712Cerebral Amyloid Angiopathy
DrugsMivelsiran·Aln-App
Alnylam Pharmaceuticals
Phase 2
210
Calgary, Hamilton, Kelowna, Moncton, Montreal, Ottawa, Toronto, Victoria
2024-05-17
Recruiting
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B or Factor VII Deficiency)
NCT06349473Healthy Participants, Hemophilia A, Hemophilia B, Factor VII Deficiency
DrugSR604
Equilibra Bioscience LLC
Phase 1
31
Hamilton
2024-05-10
Recruiting
Infection Prophylaxis in Total Joint Replacement
NCT06126614Periprosthetic Joint Infection
DrugsVancomycin Hydrochloride·Chlorhexidine Gluconate
Hamilton Health Sciences Corporation
Phase 3
21,006
Hamilton
2024-05-07
Active, closed
A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
NCT06238622Idiopathic Pulmonary Fibrosis, Progressive Pulmonary Fibrosis
DrugNerandomilast
Boehringer Ingelheim
Phase 3
1,666
Edmonton, Kelowna, Vancouver, Moncton, Halifax, Hamilton, Windsor, Montreal
2024-05-06
Recruiting
Intra-articular Corticosteroid With Hyaluronic Acid Plus Physiotherapy for Hip Pathologies (NON-OP HIP)
NCT06653985Osteoarthritis, Femoroacetabular Impingement Syndrome, Labrum Injury of the Hip Joint
ArthroBiologix Inc.
Not applicable
100
Hamilton
2024-05-01
Recruiting
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
NCT06164730Heterozygous Familial Hypercholesterolemia, Premature Coronary Heart Disease
DrugVERVE-102
Verve Therapeutics, Inc.
Phase 1
85
Chicoutimi, Hamilton, Montreal, Québec, Toronto, Vancouver
2024-04-30
Recruiting
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
NCT05485961End Stage Kidney Disease
DrugClazakizumab
CSL Behring
Phase 2/3
3,110
Edmonton, Halifax, Hamilton, Kingston, London, Oshawa, Montreal, Longueuil
2024-04-27
Recruiting
RAFT - Pace &Ablate
NCT06299514Atrial Fibrillation, Heart Failure, Pacemaker, Arrhythmia Atrial
Habib Khan
Not applicable
600
Victoria, Halifax, Hamilton, Kitchener, London, Newmarket, Ottawa, Toronto
2024-04-25
Recruiting
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
NCT06172296Ganglioneuroblastoma, Nodular, Neuroblastoma
DrugsDinutuximab·Isotretinoin·CDDP·Doxorubicin
National Cancer Institute (NCI)
Phase 3
478
Calgary, Edmonton, Vancouver, Winnipeg, St. John's, Halifax, Hamilton, London
2024-04-19
Recruiting
Optimizing Care for Children Hospitalized With Community-acquired Pneumonia: Novel Diagnostics
NCT06114888Community-acquired Pneumonia
Jeffrey
Not applicable
75
Hamilton
2024-04-17
Recruiting
Paclitaxel and Ramucirumab +/- Zanidatamab in HER2 Postive Advanced Gastroesophageal Adenocarcinoma
NCT06043427Gastroesophageal Adenocarcinoma
DrugsZanidatamab·Ramucirumab·Paclitaxel
Canadian Cancer Trials Group
Phase 2
168
Calgary, Vancouver, Winnipeg, Halifax, Barrie, Hamilton, Kingston, Kitchener
2024-04-16
Active, closed
A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.
NCT06372145Relapsing Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Progressive Relapsing Multiple Sclerosis
DrugTeriflunomide
Sanofi
Phase 3
2,500
Edmonton, Burnaby, Vancouver, Halifax, Hamilton, Ottawa, Toronto, Gatineau
2024-04-16
Recruiting
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
NCT06307652Heart Failure and Impaired Kidney Function
AstraZeneca
Phase 3
3,850
New Westminster, North Vancouver, Vancouver, Winnipeg, Sydney, Cambridge, Hamilton, London
2024-04-12
Active, closed
A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis
NCT06329401Pulmonary Fibrosis, Progressive Pulmonary Fibrosis, Pulmonary Fibrosis Secondary to Systemic Sclerosis, Pulmonary Fibrosis, Interstitial Lung Disease
DrugPirfenidone
Avalyn Pharma Inc.
Phase 2
375
Vancouver, Ajax, Hamilton, Montreal, Québec, Trois-Rivières
2024-04-03
Active, closed
[Ac-225]-PSMA-62 Trial in Oligometastatic Hormone Sensitive and Metastatic Castration Resistant Prostate Cancer
NCT06229366Prostate Cancer, Metastatic Castration-resistant Prostate Cancer, Oligometastatic Prostate Carcinoma, Hormone Sensitive Prostate Cancer
Eli Lilly and Company
Phase 1
142
Hamilton, Montreal, Québec, Saguenay, Toronto, Vancouver
2024-04-03
Recruiting
A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis
NCT05828069Recurrent Langerhans Cell Histiocytosis, Refractory Langerhans Cell Histiocytosis
DrugTovorafenib
National Cancer Institute (NCI)
Phase 2
48
Edmonton, Vancouver, Halifax, Hamilton, London, Toronto, Montreal, Sherbrooke
2024-03-28
Recruiting
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
NCT06256588Neoplasms, Head and Neck
DrugDostarlimab
GlaxoSmithKline
Phase 3
864
Greater Sudbury, Hamilton, Toronto, Montreal
2024-03-21
Recruiting
The IMPACT Implementation-Effectiveness Trial
NCT06323707Cancer
McMaster University
Phase 2
129
Burlington, Hamilton, St. Catharines
2024-03-15
Recruiting
Radiation OmisSion in PAtients With CLinically Node Negative Breast Cancer Undergoing Lumpectomy
NCT05866458Breast Cancer
Ontario Clinical Oncology Group (OCOG)
Observational
352
Prince George, Barrie, Hamilton, Kingston, Thunder Bay, Toronto, Montreal, Québec
2024-03-12
Recruiting
Pilot Feasibility Study of Fecal Microbiota Transplant for the Treatment of Small Intestinal Bacterial Overgrowth
NCT05967871Small Intestinal Bacterial Overgrowth
DrugFecal Microbiota Transplant
McMaster Children's Hospital
Phase 1
20
Hamilton, Toronto
2024-03-11
Recruiting
First-in-human Study of 225Ac-PSMA-Trillium (BAY 3563254) in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)
NCT06217822Advanced Metastatic Castration-resistant Prostate Cancer, Prostate Specific Membrane Antigen (PSMA) Expression
Bayer
Phase 1
198
Edmonton, Vancouver, Hamilton, Toronto, Montreal, Sherbrooke
2024-03-07
Active, closed
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)
NCT06292013Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)
DrugLepodisiran
Eli Lilly and Company
Phase 3
17,300
Brampton, Chicoutimi, Hamilton, Joliette, London, Longueuil, Moncton, New Westminster
2024-03-05
Recruiting
The STOP-MED CTRCD Trial
NCT06183437Heart Failure, Cardiotoxicity, Cardiac Toxicity, Antineoplastics Toxicity
Dinesh Thavendiranathan
Phase 4
335
Edmonton, Winnipeg, Hamilton, Ottawa, Toronto
2024-03-04
Not yet open
Outcomes of Children After Hospitalization in Intensive Care Unit
NCT06124092Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
St. Justine's Hospital
Observational
690
Calgary, Vancouver, Hamilton, Ottawa, Toronto, Montreal, Sherbrooke
2024-03
Active, closed
A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor
NCT06241118Dermatitis Atopic
DrugsPimecrolimus·Amlitelimab·Tacrolimus
Sanofi
Phase 3
464
Calgary, Edmonton, Burlington, Hamilton, London, Toronto, Regina
2024-02-29
Active, closed
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
NCT06260722Diabetes Mellitus, Type 2
DrugsRetatrutide·Semaglutide
Eli Lilly and Company
Phase 3
1,250
Calgary, Edmonton, Brampton, Hamilton, Sarnia, Toronto, Whitby, Montreal
2024-02-21
Recruiting
Low-value Care, and Variation in Practice for Children Hospitalized With Bronchiolitis
NCT06506474Bronchiolitis
St. Justine's Hospital
Observational
3,000
Calgary, Edmonton, Vancouver, Halifax, Hamilton, Kingston, London, Oshawa
2024-02-13
Recruiting
Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma
NCT05998642Non-hodgkin Lymphoma
DrugsIbrutinib·Methotrexate·Rituximab
Canadian Cancer Trials Group
Phase 2
30
Calgary, Vancouver, Hamilton, Ottawa, Toronto, Montreal, Québec, Regina
2024-02-13
Not yet open
A Phase I, Single-blind, Randomized Study of the Safety and Efficacy of Cellularized Integra® Using Autologous Burn-derived Stem Cells
NCT05344521Burns
Hamilton Health Sciences Corporation
Phase 1
29
Hamilton
2024-02
Active, closed
A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa
NCT06212999Hidradenitis Suppurativa (HS)
DrugPovorcitinib
Incyte Corporation
Phase 3
617
Calgary, Edmonton, Surrey, Winnipeg, Fredericton, Barrie, Hamilton, London
2024-01-30
Recruiting
Efficacy and Safety of CSL222 (Etranacogene Dezaparvovec) Gene Therapy in Adults With Hemophilia B With Pretreatment Adeno-associated Virus Serotype 5 (AAV5) Neutralizing Antibodies (Nabs)
NCT06003387Hemophilia B
CSL Behring
Phase 3
35
Hamilton
2024-01-30
Recruiting
COLchicine and Thiamine in Heart Failure Due to Ischemic Heart Disease
NCT05873881Heart Failure
DrugColchicine
Hamilton Health Sciences Corporation
Phase 3
2,500
Hamilton
2024-01-29
Active, closed
A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide
NCT06208150Multiple Myeloma
DrugsElotuzumab·Talquetamab·Velcade·Teclistamab
Janssen Research & Development, LLC
Phase 3
838
Calgary, Vancouver, Halifax, Hamilton, Toronto, Montreal, Saskatoon
2024-01-22
Active, closed
A Trial That Evaluates Disease Characteristics in Hemophilia B Adult Male Participants Receiving Prophylaxis With Standard of Care Factor IX Protein (FIX) Replacement Therapy
NCT05568459Hemophilia B
Regeneron Pharmaceuticals
Observational
11
Hamilton, Montreal
2024-01-17
Active, closed
A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis
NCT06143878Plaque Psoriasis
DrugsIcotrokinra·Deucravacitinib
Janssen Research & Development, LLC
Phase 3
774
Surrey, St. John's, Ajax, Barrie, Hamilton, Richmond Hill, Waterloo, Windsor
2024-01-17
Active, closed
PeRiopEratiVE SmokiNg CessaTion Trial
NCT05102123Smoking (Tobacco) Addiction, Smoking Cessation
DrugCytisine
Population Health Research Institute
Phase 3
1,720
Hamilton, Kingston, London
2024-01-15
Active, closed
The Pharmacokinetics of Single Dose Oral Tetrahydrocannabinol and Cannabidiol
NCT05742724Cannabis, Chronic Kidney Diseases, Dialysis
McMaster University
Phase 1
24
Hamilton
2024-01-11
Active, closed
The Effect of Pharmacist-Initiated Home Blood Pressure Monitoring on Blood Pressure Control in Women
NCT05991414Hypertension
University of Alberta
Not applicable
368
Aylmer, Barrie, Blenheim, Collingwood, Fergus, Greater Sudbury, Hamilton, Kingston
2024-01-09
Active, closed
A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia
NCT05761171Recurrent Acute Leukemia of Ambiguous Lineage, Recurrent Acute Lymphoblastic Leukemia, Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage, Recurrent Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged
DrugsHydrocortisone Sodium Succinate·Revumenib·Fludarabine Phosphate·Calaspargase Pegol
Children's Oncology Group
Phase 2
78
Vancouver, Winnipeg, Halifax, Hamilton, London, Ottawa, Toronto, Montreal
2024-01-08
By invitation
Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
NCT06191315Wheezing, Asthma
DrugDupilumab
Sanofi
Phase 3
90
Edmonton, Vancouver, Burlington, Hamilton, Montreal, Sherbrooke
2024-01-03
Recruiting
Emergency Medicine Pulmonary Embolism Testing Multicentre Study
NCT06320236Pulmonary Embolism, D-dimer, Diagnosis
Dr. Kerstin de Wit
Observational
4,000
Hamilton, Kingston, London, Ottawa
2024-01-01
Active, closed
Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation
NCT06096337Persistent Atrial Fibrillation
Boston Scientific Corporation
Not applicable
484
Hamilton, Québec
2023-12-28
Active, closed
Trial of Efficacy and Safety of NS-229 Versus Placebo in Patients With Eosinophilic Granulomatosis With Polyangiitis
NCT06046222Eosinophilic Granulomatosis With Polyangiitis, Churg-Strauss Syndrome
NS Pharma, Inc.
Phase 2
45
Edmonton, Hamilton, Toronto
2023-12-20
Active, closed
A Study To Assess Adverse Events and Effectiveness of Upadacitinib Oral Tablets in Adult and Adolescent Participants With Vitiligo
NCT06118411Vitiligo
DrugUpadacitinib
AbbVie
Phase 3
614
Calgary, Surrey, Winnipeg, Fredericton, Hamilton, Waterloo, Québec, Saint-Jérôme
2023-12-19
Active, closed
A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib
NCT05734105GIST
DrugsRipretinib·Sunitinib
Deciphera Pharmaceuticals, LLC
Phase 3
54
Calgary, Hamilton, Toronto, Montreal
2023-12-13
Active, closed
A Study to Investigate Efficacy, Safety, and Tolerability of Remibrutinib Compared With Placebo in Adults With CINDU Inadequately Controlled by H1-antihistamines
NCT05976243Chronic Inducible Urticaria
DrugRemibrutinib
Novartis Pharmaceuticals
Phase 3
362
Winnipeg, Hamilton, Trois-Rivières
2023-12-07
Active, closed
Economic Evaluation of Stream™ Platform
NCT05994625Anastomotic Leak
FluidAI Medical
Phase 3
215
Hamilton
2023-12-06
Recruiting
AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma
NCT06106945Multiple Myeloma
DrugsElranatamab·Pomalidomide·Dexamethasone
AstraZeneca
Phase 1/2
226
Hamilton, Ottawa, Toronto, Montreal, Nova Scotia
2023-12-05
Recruiting
A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
NCT06215716NASH With Fibrosis, MASH With Fibrosis
DrugEfruxifermin
Akero Therapeutics, Inc
Phase 3
1,650
Edmonton, Hamilton, Toronto, Vaughan, Montreal, Terrebonne
2023-12-01
Active, closed
Family Integration in Therapy Activities in the Intensive Care Unit: The FIT-ICU Feasibility Study
NCT06071793Critical Illness, Delirium
St. Joseph's Healthcare Hamilton
Not applicable
20
Brantford, Hamilton
2023-11-30
Recruiting
The Fourth Left Atrial Appendage Occlusion Study
NCT05963698Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism
Hamilton Health Sciences Corporation
Not applicable
4,000
Calgary, Vancouver, Winnipeg, Burlington, Cambridge, Hamilton, Kitchener, London
2023-11-30
Recruiting
Evaluating Simplified Layered Consent for Clinical Trials
NCT06168474Staphylococcus Aureus Bacteremia
Sunnybrook Health Sciences Centre
Not applicable
346
Calgary, Hamilton, Ottawa, Toronto, Montreal, Québec
2023-11-28
Recruiting
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
NCT06103864Breast Cancer
DrugsDato-DXd·Durvalumab·Nab-paclitaxel·Gemcitabine
AstraZeneca
Phase 3
625
Barrie, Hamilton, Toronto, Greenfield Park, Montreal, Québec, Regina, Saskatoon
2023-11-23
Recruiting
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
NCT05172973Aortic Valve Insufficiency, Aortic Valve Stenosis
Edwards Lifesciences
Not applicable
200
Vancouver, Hamilton, Québec
2023-11-22
Recruiting
A Randomized Trial of Five Fraction Partial Breast Irradiation (RAPID2)
NCT05417516Breast Neoplasm Female, Radiotherapy, Cosmetic Outcome
Ontario Clinical Oncology Group (OCOG)
Phase 3
910
Calgary, Victoria, Halifax, Barrie, Hamilton, London, Newmarket, Sault Ste. Marie
2023-11-20
By invitation
Combining Ultrasound and Biomarkers to Diagnose Superficial Endometriosis
NCT05523284Endometriosis (Diagnosis), Endometriosis
McMaster University
Observational
50
Hamilton
2023-11-15
Active, closed
Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.
NCT06042478Chronic Spontaneous Urticaria
DrugsOmalizumab·Remibrutinib
Novartis Pharmaceuticals
Phase 3
470
Edmonton, Hamilton, London, Niagara Falls, Québec, Verdun
2023-11-15
Active, closed
A Study Evaluating Efruxifermin in Subjects With Non-invasively Diagnosed Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Nonalcoholic Fatty Liver Disease (NAFLD)/Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
NCT06161571NASH/MASH, NAFLD/MASLD
DrugEfruxifermin
Akero Therapeutics, Inc
Phase 3
700
Edmonton, Hamilton, Toronto, Vaughan, Terrebonne
2023-11-10
Active, closed
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
NCT06122779Heart Failure
DrugBMS-986435
Bristol-Myers Squibb
Phase 2
227
Hamilton, Toronto
2023-11-07
Recruiting
Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy
NCT05615844Open tíbia Fracture
University of Maryland, Baltimore
Phase 3
312
New Westminster, Vancouver, Hamilton, London, Ottawa
2023-11-05
Recruiting
TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II
NCT05848687Lymphoblastic Leukemia
DrugsVorinostat·Mitoxantrone·PEG-Asparaginase·Mercaptopurine
Tanja Andrea Gruber
Phase 1/2
90
Calgary, Edmonton, Vancouver, Hamilton, Montreal, Québec
2023-11-03
Recruiting
Albumin To Enhance Recovery After Acute Kidney Injury
NCT04705896Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness
Ottawa Hospital Research Institute
Phase 4
856
Calgary, Winnipeg, Halifax, Hamilton, Kingston, North York, Ottawa, Scarborough Village
2023-11-02
Recruiting
Short Duration Electrical Stimulation to Improve Outcomes After Cubital Tunnel Release (SELECT) Trial
NCT05980767Neuropathy;Peripheral
Epineuron Technologies Inc.
Not applicable
26
Hamilton
2023-11-01
Active, closed
Minimally Displaced Femoral Neck Fracture Pilot Study
NCT05947058Femoral Neck Fractures
University of Maryland, Baltimore
Not applicable
40
Vancouver, Hamilton, London
2023-11-01
Recruiting
Thresholds In Food Allergy evaluaTion And predictioN
NCT06038019Tree Nut Allergy, Food Allergy
Hamilton Health Sciences Corporation
Observational
2,000
Hamilton
2023-11-01
Recruiting
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
NCT05943535Progressive Pulmonary Fibrosis, Interstitial Lung Disease
DrugTreprostinil
United Therapeutics
Phase 3
698
Vancouver, Ajax, Hamilton, Montreal, Québec, Sherbrooke, Saskatoon
2023-10-30
Active, closed
A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis
NCT06025578Progressive Pulmonary Fibrosis
DrugAdmilparant
Bristol-Myers Squibb
Phase 3
1,057
Sherwood Park, Kelowna, Vancouver, Burlington, Hamilton, Owen Sound, Toronto, Montreal
2023-10-25
Recruiting
PATHFINDER: Evaluating the Optimal First-Line Treatment Strategy for Moderate-to-Severely Active Ileal-dominant Crohn's Disease
NCT05928039Crohn Disease
DrugAnti-IL12/23
University of Calgary
Phase 4
297
Calgary, Edmonton, Vancouver, Halifax, Brampton, Brantford, Hamilton, London
2023-10-25
Active, closed
Shoulder Instability Trial Comparing Arthroscopic Stabilization Benefits Compared With Latarjet Procedure Evaluation - STABLE Definitive Trial
NCT05705479Shoulder Dislocation, Sport Injuries, Anterior Dislocation
McMaster University
Not applicable
114
Hamilton
2023-10-17
Recruiting
Revisiting the Universal Donor: Does Exposure to O Blood Products Affect Patient Outcomes?
NCT04859218Myelodysplastic Syndrome
McMaster University
Not applicable
30
Hamilton
2023-10-17
Recruiting
An Innovative Master Platform for Clinical Trials in Mood Disorders
NCT06408012Mood Disorders, Depressive Disorder, Bipolar and Related Disorders
St. Joseph's Healthcare Hamilton
Observational
2,200
Calgary, Vancouver, Halifax, Hamilton, Kingston, Ottawa, Toronto, Whitby
2023-10-17
Active, closed
A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation
NCT06045806Multiple Myeloma
DrugsIdecabtagene vicleucel·Endoxan·Fludara·Cytoxan
Celgene
Phase 3
79
Edmonton, Hamilton, Montreal
2023-10-16
Active, closed
A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
NCT06075667Obesity, Overweight
DrugTirzepatide
Eli Lilly and Company
Phase 3
160
Edmonton, Hamilton, Toronto, Chicoutimi
2023-10-16
Recruiting
Cannabidiol for Bipolar Depression (CBD-BD)
NCT05867849Bipolar Disorder
DrugCannabidiol
University of British Columbia
Phase 3
360
Vancouver, Hamilton, Kingston, Toronto, Montreal
2023-10-15
Recruiting
A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata
NCT06012240Alopecia Areata
DrugUpadacitinib
AbbVie
Phase 3
1,500
Calgary, Edmonton, Surrey, Winnipeg, Barrie, Greater Sudbury, Hamilton, Markham
2023-10-11
Active, closed
A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma
NCT05257083Multiple Myeloma
DrugsCilta-cel·Bortezomib·Daratumumab·Lenalidomide
Stichting European Myeloma Network
Phase 3
759
Edmonton, Hamilton, Montreal, Ottawa, Québec, Toronto, Vancouver
2023-10-10
Recruiting
Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents
NCT05867472Intensive Care Units, Pediatric, Anesthetics, Inhalation, Mechanically Ventilated, Critically Ill Children
DrugIsoflurane Inhalant Product
Sunnybrook Health Sciences Centre
Phase 3
60
Hamilton, London, Toronto
2023-10-10
Recruiting
D3-Creatine and Skeletal Muscle in Older Adults
NCT06630949Aging, Muscle Loss
McMaster University
Observational
350
Hamilton
2023-10-01
Recruiting
Healthy Outcomes for Muscle with Exercise in T1D
NCT05740514Diabetes Mellitus, Type 1
McMaster University
Not applicable
168
Hamilton
2023-10-01
Recruiting
Indocyanine Green for Detection of Sentinel Lymph Nodes In Comparison to ICG Plus Technetium in the Evaluation of Vulvar Squamous Cell Carcinoma
NCT06039111Vulvar Cancer
Hamilton Health Sciences Corporation
Observational
58
Hamilton
2023-10-01
Active, closed
A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
NCT06151964Overweight and Obesity
DrugAZD9550
AstraZeneca
Phase 1/2
166
Surrey, Hamilton, Sarnia, Stouffville, Toronto, Sherbrooke
2023-09-29
Recruiting
Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)
NCT06079671Locally Advanced Cervical Cancer
DrugVolrustomig
AstraZeneca
Phase 3
800
Hamilton, London, Toronto, Montreal, Ste-Foy
2023-09-22
Recruiting
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A
NCT05987449Hemophilia A
Hoffmann-La Roche
Phase 1/2
60
Vancouver, Hamilton
2023-09-21
Active, closed
A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)
NCT05904886Hepatocellular Carcinoma
DrugsTiragolumab·Tecentriq·Avastin·Atezolizumab
Hoffmann-La Roche
Phase 3
687
Hamilton, Toronto, Montreal
2023-09-14
Active, closed
A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis
NCT06003426Idiopathic Pulmonary Fibrosis
DrugAdmilparant
Bristol-Myers Squibb
Phase 3
1,255
Sherwood Park, Kelowna, Vancouver, Burlington, Hamilton, Owen Sound, Toronto, Greenfield Park
2023-09-14
Recruiting
Left vs Left Randomized Clinical Trial
NCT05650658Heart Failure, Heart Failure With Reduced Ejection Fraction, AV Block, LBBB
Baylor College of Medicine
Not applicable
2,136
Edmonton, Vancouver, Victoria, Halifax, Hamilton, Newmarket, Ottawa, Toronto
2023-09-13
Active, closed
Implementation of P-INPAC
NCT06645639Malnutrition, Child, Nutrition Poor
The Hospital for Sick Children
Observational
600
Hamilton, Toronto, Montreal
2023-09-04
Recruiting
TRADE Trial - Tree Nut Immunotherapy Route Development and Evaluation
NCT05521711Tree Nut Allergy, Food Allergy
Hamilton Health Sciences Corporation
Not applicable
60
Hamilton
2023-09-01
Active, closed
A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations
NCT06052267Asthma
Teva Branded Pharmaceutical Products R&D LLC
Phase 3
2,772
Edmonton, Ajax, Etobicoke, Hamilton, Winchester, Windsor
2023-08-30
Recruiting
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)
NCT06126224Psychosis Associated With Alzheimer's Disease
DrugKarXT
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Phase 3
500
Calgary, Hamilton, Toronto, Whitby, Montreal, Verdun
2023-08-28
Recruiting
A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma
NCT06023589Asthma
DrugTezepelumab
AstraZeneca
Phase 3
231
Edmonton, Burlington, Hamilton, Windsor, Montreal
2023-08-24
By invitation
The Role of a Mediterranean Diet in Patients With Endometriosis: a Feasibility Trial
NCT05411549Endometriosis
McMaster University
Not applicable
24
Hamilton
2023-08-22
Recruiting
A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis
NCT05995964Atopic Dermatitis
DrugTilrekimig
Pfizer
Phase 2
340
Winnipeg, Greater Sudbury, Hamilton, Mississauga, Toronto, Chicoutimi, Québec
2023-08-22
Recruiting
Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients
NCT05829317Critical Illness, New Onset Atrial Fibrillation
DrugMagnesium sulfate
Dr. Stephanie Sibley
Phase 4
200
Hamilton, Kingston, Ottawa
2023-08-20
Recruiting
Regeneration of Acutely Injured Nerves With Temporary Electrical Stimulation
NCT05721261Nerve Injury
Epineuron Technologies Inc.
Not applicable
110
Edmonton, Saint John, Hamilton, London, Newmarket, Toronto
2023-08-11
Recruiting
Objective Concussion Assessment Using MRI and Metabolomics
NCT05993351Concussion, Brain
St. Joseph's Healthcare Hamilton
Observational
100
Hamilton
2023-08-11
Recruiting
Evaluating a Virtual Stepped Care Portal in Youth Awaiting Tertiary Chronic Pain Care: An Implementation-Effectiveness Hybrid Type III Study
NCT05894772Chronic Pain
The Hospital for Sick Children
Not applicable
93
Halifax, Hamilton, London, Ottawa, Toronto, Montreal, Saskatoon, Calgary
2023-08-05
Active, closed
A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver
NCT05677113Colorectal Cancer, Liver Metastases
Sunnybrook Health Sciences Centre
Phase 2
115
Hamilton, London, Ottawa, Toronto
2023-08-01
Recruiting
A Study of Reduced Dosing of the Nonavalent HPV Vaccine in Women Living With HIV
NCT05495906HPV, Human Papilloma Virus, Human Immunodeficiency Virus
DrugNonavalent HPV vaccine
University of British Columbia
Phase 4
275
Surrey, Vancouver, Winnipeg, Hamilton, Toronto, Montreal, Québec, Regina
2023-07-27
Recruiting
RCT Evaluating First Time Shoulder Dislocation
NCT05715021Shoulder Dislocation, Sport Injury, Anterior Dislocation
McMaster University
Not applicable
100
Hamilton
2023-07-12
Recruiting
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
NCT05980949Psychosis Associated With Alzheimer's Disease
DrugKarXT
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Phase 3
1,000
Calgary, Hamilton, Whitby, Montreal, Verdun
2023-07-11
By invitation
A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an Agios-Sponsored Mitapivat Study
NCT05777993Pyruvate Kinase Deficiency, Anemia, Hemolytic, Sickle Cell Disease, Thalassemia
DrugMitapivat
Agios Pharmaceuticals, Inc.
Phase 4
59
Hamilton, Toronto
2023-07-06
Active, closed
The Impact of Plant-based Blends on Skeletal Muscle Protein Synthesis Rates in Older Adults
NCT05917223Nutrition, Healthy
McMaster University
Not applicable
48
Hamilton
2023-07-01
Recruiting
Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease
NCT05701358Acute Myocardial Infarction, Coronary Artery Disease
Population Health Research Institute
Not applicable
5,100
Montreal, Brampton, Edmonton, Hamilton, Kingston, Kitchener, London, Newmarket
2023-06-22
Recruiting
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
NCT05427370Coronary Artery Disease, Heart Failure Systolic
Sunnybrook Health Sciences Centre
Not applicable
754
Calgary, Edmonton, New Westminster, Vancouver, Winnipeg, Halifax, Hamilton, London
2023-06-22
Active, closed
A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy
NCT05889182Hidradenitis Suppurativa
DrugUpadacitinib
AbbVie
Phase 3
1,328
Calgary, Edmonton, Red Deer, Surrey, Winnipeg, St. John's, Hamilton, London
2023-06-21
Recruiting
Frailty Assessments for Risk Assessment in Gynecologic Oncology Patients
NCT05738252Gynecologic Cancer, Frailty, Oncology
Population Health Research Institute
Observational
280
Hamilton, Mississauga, Toronto
2023-06-15
Recruiting
Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer
NCT05601440Breast Cancer
DrugsCFI-402257·Camonsertib·Lunresertib·CFI-400945
Canadian Cancer Trials Group
Phase 2
484
Calgary, Kelowna, Vancouver, Halifax, Hamilton, Kingston, Ottawa, Toronto
2023-06-13
Active, closed
Back to Living Well: Implementation of a Community-based Program for Low Back Pain
NCT05929846Low Back Pain
McMaster University
Observational
90
Hamilton
2023-06-10
Active, closed
An Observational Study to Assess Change in Disease Activity and Adverse Events In Adult Participants With Moderate to Severe Active Crohn's Disease (CD)
NCT05841537Crohn's Disease
AbbVie
Observational
1,019
Calgary, Edmonton, Lethbridge, Kelowna, New Westminster, Victoria, Moncton, Hamilton
2023-06-09
Recruiting
A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy
NCT05646862Breast Cancer
DrugsBupropion·Omeprazole·Alpelisib·Inavolisib
Hoffmann-La Roche
Phase 3
420
Calgary, Edmonton, Vancouver, Moncton, Hamilton, Ottawa, Montreal
2023-06-07
Recruiting
A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors
NCT05948865Cancer, Cancer, Lung
DrugSYS6010
Conjupro Biotherapeutics, Inc.
Phase 1
132
Edmonton, Hamilton, Toronto
2023-06-06
Recruiting
Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO)
NCT04762134Bacterial Sexually Transmitted Diseases
DrugDoxycycline Hyclate
Jonathan Troy Grennan
Not applicable
560
Calgary, Vancouver, Hamilton, Ottawa, Toronto, Montreal
2023-06-02
Recruiting
Surgical Ablation of AF Efficacy Trial
NCT05434819Atrial Fibrillation, Heart Failure
Population Health Research Institute
Not applicable
2,000
Hamilton
2023-06-01
Recruiting
Therapeutic Plasma Exchange in Septic Shock: A Pilot Study
NCT05093075Septic Shock
University of Manitoba
Phase 2
80
Calgary, Edmonton, Winnipeg, Hamilton, Kingston, Ottawa, Toronto, Montreal
2023-06-01
Active, closed
The Effects of Protein Supplementation With or Without Urolithin A During Single-leg Immobilization
NCT05814705Healthy, Muscle Disuse Atrophy
McMaster University
Not applicable
24
Hamilton
2023-06-01
Recruiting
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
NCT05675410Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
DrugsProcarbazine hydrochloride·Vinblastine Sulfate·Bleomycin·Brentuximab Vedotin
National Cancer Institute (NCI)
Phase 3
1,875
Calgary, Edmonton, Vancouver, Winnipeg, Halifax, Hamilton, London, Ottawa
2023-05-11
Active, closed
Treat & Extend Versus Fixed Dosing With Faricimab for Management of Diabetic Macular Edema: A Pragmatic, Multi-center, Open-label, Randomized, Controlled Trial
NCT05610319Diabetic Macular Edema
DrugFaricimab
McMaster University
Phase 4
446
Calgary, New Westminster, Vancouver, Hamilton, London, Ottawa, Toronto, Montreal
2023-05-01
Recruiting
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NCT04124120Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting
Weill Medical College of Cornell University
Not applicable
2,300
Edmonton, Winnipeg, Saint John, St. John's, Greater Sudbury, Hamilton, London, Ottawa
2023-04-17
Recruiting
PRospective Evaluation of Peripartum Anticoagulation ManaGement for ThrOmboembolism
NCT05756244Pregnancy Related, Venous Thromboembolism
University of Calgary
Observational
825
Calgary, Edmonton, Vancouver, Winnipeg, Hamilton, Ottawa, Toronto, Montreal
2023-04-04
Active, closed
A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies
NCT05794906Biochemically Recurrent Prostate Cancer
DrugDarolutamide
Bayer
Phase 3
985
Calgary, Edmonton, Abbotsford British Columbia, Vancouver, Victoria, Halifax, Hamilton, London
2023-04-03
Active, closed
A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)
NCT05714202Bladder Cancer
DrugsTAR-200·Cetrelimab
Janssen Research & Development, LLC
Phase 3
1,135
Halifax, Hamilton, Toronto, Montreal, Québec, Saint Jerome Quebec
2023-03-23
Recruiting
A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma
NCT05650632Multiple Myeloma
DrugEtentamig
AbbVie
Phase 1
210
Hamilton, Ottawa
2023-03-21
Recruiting
Vancomycin Dosing for Serious MRSA Infections: A Non-inferiority Randomized Trial of Trough Level Versus AUC/MIC
NCT04793152MRSA
DrugVancomycin
Anthony Bai
Not applicable
700
Hamilton, Kingston, Montreal
2023-03-20
Recruiting
Confirming the Effectiveness of Online Guided Self-Help Family-Based Treatment for Adolescent Anorexia Nervosa
NCT05563649Anorexia Nervosa
Stanford University
Not applicable
200
Hamilton
2023-03-17
Active, closed
A Study of Doravirine/Islatravir (DOR/ISL, MK-8591A) for the Treatment of Human Immunodeficiency Virus 1 (HIV-1) Infection in Participants Who Previously Received DOR/ISL (MK-8591A-054)
NCT05766501HIV Infection
DrugDOR/ISL
Merck Sharp & Dohme LLC
Phase 3
641
Hamilton, Toronto, Montreal
2023-03-17
Recruiting
Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
NCT05776069Von Willebrand Diseases
DrugVGA039
Vega Therapeutics, Inc
Phase 1/2
116
Hamilton, Kingston, Toronto
2023-03-16
Active, closed
Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
NCT05445778Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
DrugsMirvetuximab Soravtansine·Bevacizumab
AbbVie
Phase 3
520
Calgary, Edmonton, Surrey, Vancouver, Hamilton, Kingston, Ottawa, Toronto
2023-03-15
Recruiting
AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
NCT05402072Hip Arthroscopy, Articular Cartilage Defect, Microfractures
McMaster University
Phase 1
40
Hamilton
2023-03-13
Active, closed
DOR/ISL in HIV-1 Antiretroviral Treatment-naïve Participants (MK-8591A-053)
NCT05705349HIV-1 Infection
DrugsDOR/ISL·B/F/TAF
Merck Sharp & Dohme LLC
Phase 3
537
Hamilton, Toronto, Montreal, Regina
2023-03-08
Active, closed
A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma
NCT05625399Melanoma
DrugsPhesgo·Relatlimab·Nivolumab
Bristol-Myers Squibb
Phase 3
579
Calgary, Hamilton, Ottawa, Toronto, Québec
2023-03-06
Active, closed
REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels
NCT05669755Cardiovascular Disease
DrugsCagrilintide·Semaglutide
Novo Nordisk A/S
Phase 3
7,101
Calgary, Moncton, Halifax, Barrie, Brampton, Cambridge, Hamilton, Toronto
2023-03-01
Recruiting
Longitudinal Study for Central Nervous System Vasculitis
NCT05734404Central Nervous System Vasculitis, CNS Vasculitis, CNSV, Vasculitis
University of Pennsylvania
Observational
40
Hamilton, Toronto
2023-03-01
Active, closed
A Treatment Effectiveness Study Among SLE Patients Receiving Anifrolumab in Routine Clinical Practice.
NCT05637112Systemic Lupus Erythematosus
AstraZeneca
Observational
551
Calgary, Winnipeg, Hamilton, Orillia, Toronto, Rimouski, Sherbrooke, Ste-Foy
2023-02-27
Active, closed
DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)
NCT05566795Low-grade Glioma, Rapidly Accelerated Fibrosarcoma (RAF) Altered Glioma, Pediatric Low-grade Glioma
DrugsTovorafenib·Carboplatin
Day One Biopharmaceuticals, Inc.
Phase 3
418
Calgary, Edmonton, Vancouver, Hamilton, London, Ottawa, Montreal, Québec
2023-02-27
Recruiting
Anteroposterior Versus Anterolateral Electrode Position for Electrical Cardioversion of Atrial Fibrillation
NCT05511389Atrial Fibrillation, Atrial Flutter
McMaster University
Not applicable
1,750
Hamilton, Toronto, Montreal, Québec
2023-02-22
Active, closed
A Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Antiretroviral Therapy (ART) (MK-8591A-051)
NCT05631093HIV-1 Infection
DrugsDOR/ISL·B/F/TAF
Merck Sharp & Dohme LLC
Phase 3
553
Hamilton, Toronto, Montreal
2023-02-20
Active, closed
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A
NCT05685238Haemophilia A, Haemophilia A With Inhibitors
Novo Nordisk A/S
Phase 3
451
Hamilton, Toronto
2023-02-13
Recruiting
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
NCT05451004Oropharyngeal Cancer
Canadian Cancer Trials Group
Phase 3
510
Vancouver, Winnipeg, Greater Sudbury, Hamilton, Toronto, Montreal, Sherbrooke
2023-02-10
Active, closed
A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)
NCT05578976Diffuse Large B-Cell Lymphoma
DrugsEpcoritamab·Vincristine·Doxorubicin·Prednisone
Genmab
Phase 3
900
Calgary, Vancouver, Brampton, Hamilton, Saskatoon
2023-02-08
Recruiting
Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis
NCT05347238Late-Onset Neonatal Sepsis, Extreme Prematurity, Neonatal Hypotension
DrugsDopamine·Norepinephrine
Mount Sinai Hospital, Canada
Observational
550
Calgary, Vancouver, Victoria, Winnipeg, Halifax, Hamilton, London, Ottawa
2023-02-06
Recruiting
Evaluation of A Clinical Diagnostic Test for CRDS
NCT06188689Calcium Release Deficiency Syndrome (CRDS)
Population Health Research Institute
Not applicable
400
Calgary, Edmonton, Vancouver, Hamilton, London, Ottawa, Toronto, Montreal
2023-02-02
Active, closed
A Study to Test a Medicine (Fitusiran) Injected Under the Skin for Preventing Bleeding Episodes in Male Adolescent or Adult Participants With Severe Hemophilia
NCT05662319Hemophilia
DrugsAntithrombin·Clotting factor concentrates·Fitusiran
Sanofi
Phase 3
91
Hamilton, Toronto
2023-02-01
Recruiting
NSCLC Liquid Biopsies and Exhaled VOC
NCT06707519Lung Cancer, Circulating Tumor DNA
St. Joseph's Healthcare Hamilton
Observational
210
Hamilton
2023-02-01
Active, closed
Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial
NCT05478304Ischemic Stroke, Systemic Embolism
AtriCure, Inc.
Not applicable
6,573
Calgary, Edmonton, New Westminster, Saint John, Halifax, Hamilton, Kingston, London
2023-01-25
Recruiting
VIrtual Care To Improve Outcomes and RecoverY From Heart Failure Hospitalization
NCT05724433Heart Failure
Population Health Research Institute
Not applicable
891
Hamilton, Thunder Bay, Toronto
2023-01-23
Recruiting
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
NCT05017311Major Depressive Disorder
DrugsCipralex·Brexpiprazole·Escitalopram
Nova Scotia Health Authority
Phase 4
400
Calgary, Vancouver, Halifax, Hamilton, Kingston, Ottawa, Toronto, Whitby
2023-01-20
Recruiting
Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI)
NCT05453695Sepsis, Critical Illness
McMaster University
Phase 1
36
Hamilton
2023-01-17
Recruiting
Dialectal Behaviour Therapy to Enhance Health Behaviour Change for Adolescents Living With Obesity (DIRECTION Trial)
NCT05338944Prevention, Type2Diabetes
University of Manitoba
Not applicable
90
Calgary, Winnipeg, Hamilton
2023-01-14
Active, closed
A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)
NCT05617677Systemic Lupus Erythematosus
DrugDeucravacitinib
Bristol-Myers Squibb
Phase 3
516
Calgary, Hamilton, London, Toronto, Rimouski
2023-01-12
Active, closed
PERT to Improve Quality of Life in Patients Undergoing Pancreaticoduodenectomy: A Pilot Randomized Controlled Trial
NCT05466838Pancreatic Insufficiency
Sunnybrook Health Sciences Centre
Not applicable
166
Hamilton, Kingston, London, Ottawa, Toronto
2023-01-06
Recruiting
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
NCT05640999Endometrial Cancer
Canadian Cancer Trials Group
Phase 2
393
Calgary, Edmonton, Kelowna, Prince George, Vancouver, Victoria, Barrie, Hamilton
2022-12-19
Active, closed
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
NCT05581303Atherosclerotic Cardiovascular Disease
DrugOlpasiran
Amgen
Phase 3
7,297
Vancouver, Victoria, Brampton, Cambridge, Concord, Hamilton, Mississauga, North York
2022-12-14
Recruiting
Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants
NCT05340582Patent Ductus Arteriosus After Premature Birth
DrugsIbuprofen·Acetaminophen
Mount Sinai Hospital, Canada
Phase 2
310
Edmonton, Hamilton, Toronto, Québec
2022-12-12
Recruiting
A Clinical Trial of Study Medicine (Marstacimab) in Pediatric Patients With Hemophilia A or Hemophilia B
NCT05611801Hemophilia A, Hemophilia B
DrugMarstacimab
Pfizer
Phase 3
100
Edmonton, Hamilton
2022-12-09
Active, closed
A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
NCT05600777Cough, Refractory Chronic Cough
DrugCamlipixant
Bellus Health Inc. - a GSK company
Phase 3
997
Calgary, Ajax, Hamilton, Toronto, Windsor, Montreal, Québec, Saint-Charles-Borromée
2022-12-05
Recruiting
Tryptophan for Impaired AhR Signaling in Celiac Disease
NCT05576038Tryptophan Metabolism Alterations, Celiac Disease
McMaster University
Not applicable
50
Hamilton
2022-12-01
Recruiting
Synapse 3D With Intravascular Indocyanine Green
NCT03953144Non-small Cell Lung Cancer, Primary Neoplasm
DrugIC-Green
St. Joseph's Healthcare Hamilton
Phase 1/2
32
Hamilton
2022-12-01
Recruiting
Characterizing Matrix Metalloproteinase-12 (MMP12) in Sputum
NCT04761393Emphysema
McMaster University
Observational
45
Hamilton
2022-11-29
Recruiting
An Observational Research Study of the Health of Joints in People With Haemophilia Taking the Medicine Esperoct
NCT05621746Haemophilia A
Novo Nordisk A/S
Observational
100
Hamilton
2022-11-23
Active, closed
A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
NCT05476926Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Branch Retinal Vein Occlusion
DrugsVabysmo·Faricimab
Hoffmann-La Roche
Observational
6,000
New Westminster, Don Mills, Hamilton, London, Ottawa, Vaughan, Boisbriand, Montreal
2022-11-21
By invitation
Reference Values for Videofluoroscopic Measures of Swallowing
NCT05497219Dysphagia, Oropharyngeal
University Health Network, Toronto
Not applicable
580
Hamilton, Toronto
2022-11-15
Active, closed
Dazucorilant in Patients With Amyotrophic Lateral Sclerosis
NCT05407324Amyotrophic Lateral Sclerosis
Corcept Therapeutics
Phase 2
279
Hamilton, Montreal
2022-11-15
Active, closed
Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis
NCT05583227Eosinophilic Esophagitis
DrugTezepelumab
AstraZeneca
Phase 3
368
Hamilton, London, Niagara Falls, Ottawa, Windsor
2022-11-10
Active, closed
A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
NCT05567796Obesity
DrugsCagrilintide·Semaglutide
Novo Nordisk A/S
Phase 3
3,400
Edmonton, Sherwood Park, Surrey, Victoria, Moncton, Halifax, Hamilton
2022-11-01
Recruiting
Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma
NCT05180097Hodgkin Lymphoma
DrugsBrentuximab Vedotin·Dexamethasone·Gemcitabine·Cisplatin
Canadian Cancer Trials Group
Phase 2
84
Calgary, Vancouver, St. John's, Halifax, Hamilton, London, Ottawa, Toronto
2022-11-01
Active, closed
A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV
NCT05481151Polycythemia Vera
DrugBesremi
PharmaEssentia
Phase 3
111
Calgary, Vancouver, Hamilton, Ottawa, Toronto
2022-10-26
Active, closed
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
NCT05556512Obesity, Overweight
DrugTirzepatide
Eli Lilly and Company
Phase 3
15,374
Brampton, Calgary, Chicoutimi, Courtice, Greater Sudbury, Halifax, Hamilton, Lévis
2022-10-11
Active, closed
Clinical Trial on Agitation in Alzheimer's Dementia
NCT05543681Alzheimer Disease, Agitation,Psychomotor, Care Giving Burden, NPS
IGC Pharma, LLC
Phase 2
164
Victoria, Hamilton, Toronto, Montreal
2022-10-11
Recruiting
Primary Thromboprophylaxis in Patients With Malignancy and Central Venous Catheters
NCT05029063Venous Thromboembolism, Cancer
DrugRivaroxaban
Ottawa Hospital Research Institute
Phase 3
1,828
Halifax, Brampton, Hamilton, Ottawa, Sault Ste. Marie, St. Catharines, Windsor, Greenfield Park
2022-10-05
Recruiting
Sex Differences in Metabolism Following a High-fat Meal
NCT05332301Healthy Nutrition
Kirsten Bell
Not applicable
24
Hamilton
2022-10-04
Recruiting
Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
NCT05219110Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
University of Calgary
Not applicable
1,040
Calgary, Edmonton, Hamilton, Toronto
2022-09-29
Active, closed
A Single-arm, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of P1101 in Adults With ET
NCT05482971Essential Thrombocythemia
DrugBesremi
PharmaEssentia
Phase 2
91
Calgary, Vancouver, Hamilton, Toronto
2022-09-29
Recruiting
Soluble Fibre Supplementation in NAFLD
NCT05480696Non-Alcoholic Fatty Liver Disease, Non Alcoholic Steatohepatitis, Hepatic Steatosis
McMaster University
Phase 2
60
Hamilton
2022-09-09
By invitation
Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease
NCT04905693Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease, Progressive Pulmonary Fibrosis
DrugTreprostinil
United Therapeutics
Phase 3
1,850
Vancouver, Ajax, Hamilton, Toronto, Trois-Rivières, Québec
2022-09-06
Recruiting
Frailty Rehabilitation
NCT03824106Frailty
McMaster University
Not applicable
324
Hamilton
2022-09-02
Recruiting
Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears
NCT05444465Rotator Cuff Injuries
Smith & Nephew, Inc.
Not applicable
234
Calgary, Winnipeg, Hamilton
2022-08-30
Recruiting
A Study of TAK-330 to Reverse the Effects of Factor Xa Inhibitors For Adults Needing Urgent Surgery
NCT05156983Coagulation Disorder
Takeda
Phase 3
440
Hamilton, London, Toronto, Montreal, Ontario, Québec
2022-08-24
Recruiting
REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI
NCT05246098Respiratory Disease, COVID-19, Viral Infection
McMaster University
Observational
900
Calgary, Edmonton, St. Albert, New Westminster, Winnipeg, Halifax, Brantford, Hamilton
2022-08-24
Active, closed
Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials
NCT05492578Dermatitis Atopic
DrugAmlitelimab
Sanofi
Phase 2/3
1,856
Calgary, Edmonton, Red Deer, Surrey, Winnipeg, Ajax, Barrie, Hamilton
2022-08-22
Active, closed
An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice
NCT05494606Ulcerative Colitis
AbbVie
Observational
785
Calgary, Edmonton, Lethbridge, Kelowna, Moncton, Barrie, Hamilton, London
2022-08-15
Active, closed
Aminoacidemia and Protein Kinetics in Response to the Ingestion of Plant-based Protein Blends
NCT05139160Nutrition, Healthy
McMaster University
Not applicable
8
Hamilton
2022-08-15
Active, closed
Evaluation of Rifaximin SSD for Delaying Encephalopathy Decompensation in Patients With Cirrhosis
NCT05297448Hepatic Encephalopathy
DrugRifaximin SSD
Bausch Health Americas, Inc.
Phase 3
466
Calgary, Edmonton, Vancouver, Barrie, Brampton, Hamilton, Toronto, Waterloo
2022-08-03
Active, closed
Financial Toxicity in Breast Cancer Surgery
NCT05104632Breast Cancer
McMaster University
Observational
630
Hamilton
2022-07-18
Recruiting
Abatacept in Immune Checkpoint Inhibitor Myocarditis
NCT05335928Myocarditis Acute, Cancer
DrugAbatacept
Massachusetts General Hospital
Phase 3
390
Vancouver, Hamilton
2022-07-02
Recruiting
Screening Donors, Fecal Microbiota Transplant Program in Ulcerative Colitis
NCT04926103Ulcerative Colitis Flare
Hamilton Health Sciences Corporation
Not applicable
200
Hamilton
2022-07-01
Recruiting
Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour
NCT05230758Medulloblastoma, Childhood, Cognitive Impairment
DrugGlucophage
Donald Mabbott
Phase 3
140
Calgary, Edmonton, Vancouver, Winnipeg, Halifax, Hamilton, London, Ottawa
2022-07-01
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Canadian investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 2 October 2026. https://priyalifescience.com/clinical-trials-canada/city/hamilton

Query this register directly
GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Canada and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,516 studies in total at the last sync on 02 Oct 2026, 03:18 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 807 of those studies with a site in Hamilton.

How many clinical trials are recruiting in Hamilton?

424 of the 807 studies on this page are recruiting new participants as of the 02 Oct 2026, 03:18 UTC sync. A further 51 have not yet opened recruitment, 317 are active but closed to new participants, and 15 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Hamilton), 807 studies
PhaseStudiesRecruitingShare
Phase 332114439.8%
Not applicable18810123.3%
Observational1087313.4%
Phase 21075213.3%
Phase 426173.2%
Phase 123182.9%
Phase 1/217112.1%
Phase 2/31571.9%
Phase EARLY_PHASE1210.2%

Most active sponsors

Lead sponsors with the most studies (Hamilton)
Lead sponsorStudiesRecruiting
McMaster University11455
AstraZeneca4727
Canadian Cancer Trials Group3016
National Cancer Institute (NCI)278
Hamilton Health Sciences Corporation2517
Population Health Research Institute2319
St. Joseph's Healthcare Hamilton2314
Children's Oncology Group2110
Eli Lilly and Company2012
Merck Sharp & Dohme LLC187
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.