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Clinical Trials in Canada / NCT05829317
Recruiting Phase 4

Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients

NCT05829317 · tracked via the Priya Life Science Canada tracker
Sponsor
Dr. Stephanie Sibley
Phase
Phase 4
Started
2023-08-20
Last updated
2025-09-22

Condition(s) studied

Critical IllnessNew Onset Atrial Fibrillation

Investigational drug(s) / intervention(s)

Magnesium sulfate →Placebo

Magnesium sulfate: Intravenous Magnesium sulfate

Placebo: 0.9% NaCl

Study summary

A double-blind, multi-centre, randomized, placebo-controlled, feasibility pilot trial in the prevention of new onset atrial fibrillation of critically ill patients admitted to an ICU.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria 1. Age ≥18 years; 2. Admitted to an ICU with one or more of the following: 1. Non-invasive ventilation (including CPAP, Bipap and high flow oxygen (\>10L/min) or invasive mechanical ventilation with an expected duration \>24 hours for respiratory failure (hypercarbic or hypoxic) 2. Vasopressor or inotropic support with an expected duration of \>24 hours 3. Cardiac arrest 3. Continuous cardiac monitoring. Exclusion Criteria 1. Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for \>18 hours 2. Receiving IMV for airway protection only (for example, isolated head trauma) 3. Active atrial fibrillation at the time of enrolment 4. On oral or continuous infusion of Amiodarone 5. Unlikely to survive \>24 hours or palliative patients 6. Cardiac surgery patients 7. Patients requiring parenteral magnesium therapy (e.g. pre-eclampsia, asthma) 8. Patients receiving dialysis 9. Positive pregnancy test (females \<50 years old) 10. Previously enrolled in this trial 11. Treating physician refuses enrollment

Primary outcome measure(s)

Trial sites (4)

FacilityCityRegionStatus
St Joseph's Healthcare Hamilton Hamilton Ontario Not Yet Recruiting
Kingston Health Sciences Centre Kingston Ontario Recruiting
The Ottawa Hospital - General Campus Ottawa Ontario Not Yet Recruiting
The Ottawa Hospital - Civic Campus Ottawa Ontario Not Yet Recruiting

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05829317 on ClinicalTrials.gov ↗ ← All trials in Canada