Morphine clinical trials
Morphine is named as an intervention in 44 current clinical trials in our China, Egypt, Turkey, Canada, France, Singapore, USA, Italy, Belgium, Sweden, Denmark, Poland, Switzerland, Portugal, Mexico, South Korea, Taiwan, Australia and Israel registers. 29 are recruiting patients now. The most common phase is Not applicable. The sponsor with the most trials is The Second Hospital of Anhui Medical University (2). The most-studied condition is Postoperative Pain. The EU clinical trials register (CTIS) separately lists 6 authorised or ongoing trials.
Where Morphine is approved
All regulators →Of the three regulators tracked here, the first to approve Morphine was the US, on 18 Sep 1984. It is approved in 2 of the 3 regulators tracked here.
From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.
Morphine patents and exclusivity
Expiry tracker →Protections still running for marketed products containing Morphine, as listed by the regulators. Expired patents and exclusivities, and discontinued products, are not shown.
- 3 listed patents; the last listed expires 12 Mar 2034 (US 9192608).
Reproduced from the FDA Orange Book and Purple Book (checked 8 Nov 2026) and the European Commission's Union Register of medicinal products (CC BY 4.0; the EU expiry date is calculated exactly as the Commission's register displays it). Listed patents and dates are as submitted to or published by the regulator and may not reflect litigation, invalidation, settlements, lapsed fees or later extensions. This is not legal advice or a freedom-to-operate opinion, and it does not say when a generic or biosimilar will launch.
What health systems spend on Morphine
All medicines →From NHSBSA Prescription Cost Analysis (Open Government Licence v3.0) and CMS State Drug Utilization Data. Both are gross amounts: neither system publishes its discounts or rebates per drug. Products combining several substances are not counted here.
How Morphine works
All drug targets →- Mu opioid receptor agonist AgonistTarget: OPRM1 opioid receptor mu 1✓ In ChEMBL and the Guide to Pharmacology
- AbscessPhase 3
- Acute myocardial infarctionPhase 3
- Bone fracturePhase 3
- Breast cancerPhase 3
- CancerPhase 3
- Cancer painPhase 3
- Chronic obstructive pulmonary diseasePhase 3
- Colorectal cancerPhase 3
- Endometrial cancerPhase 3
- MucositisPhase 3
Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL70, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 1627, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.
Patient leaflets for Morphine
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- IEIreland: 18 products on the HPRA listEach product record links to the HPRA, which publishes the leaflet and SmPC.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Reference identifiers for Morphine
- ATC code
- N02AA01
- ChEMBL
- CHEMBL70
- DrugBank
- DB00295
- PubChem CID
- 5288826
- CAS number
- 57-27-2
- FDA UNII
- 76I7G6D29C
- Wikidata
- Q81225
- Wikipedia
- Morphine
Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.
Trials by status
Trials by phase
Clinical trials of Morphine
44 trialsRegisters list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
Morphine in the EU trials register (CTIS)
6 trialsAuthorised or ongoing trials in the EU Clinical Trials Information System that list a product containing Morphine. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.
Morphine across our data
Ireland · EU · USThe same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.
Licensed in Ireland (HPRA)
18 single-substance products containing Morphine on the HPRA medicines list.
- MST Continus 10 mg Prolonged-release tabletsMundipharma Pharmaceuticals Limited · PA1688/004/002 · Marketed
- MST Continus 100mg Prolonged-release tabletsMundipharma Pharmaceuticals Limited · PA1688/004/006 · Marketed
- MST Continus 15 mg Prolonged-release tabletsMundipharma Pharmaceuticals Limited · PA1688/004/003 · Marketed
- MST Continus 30 mg Prolonged-release tabletsMundipharma Pharmaceuticals Limited · PA1688/004/004 · Marketed
- MST Continus 5 mg prolonged-release tabletsMundipharma Pharmaceuticals Limited · PA1688/004/001 · Marketed
Supply shortages
- Morphine Sulfate InjectionUS (FDA) · Current · updated 3 Nov 2026
- Morphine Sulfate TabletUS (FDA) · Resolved · updated 22 Dec 2025
Conditions studied with Morphine
83 conditionsAll 83 conditions
| Condition (as registered) | Trials |
|---|---|
| Postoperative Pain | 5 |
| Pain, Postoperative | 4 |
| Pain Management | 2 |
| Pain After Surgery | 2 |
| Morphine | 2 |
| Cesarean Section | 2 |
| Analgesia | 2 |
| Postoperative Pain Management | 2 |
| Anesthesia | 2 |
| Pain | 2 |
| Respiratory Depression | 2 |
| Scoliosis; Adolescence | 1 |
| Analgesia, Patient-controlled | 1 |
| Laparoscopic Surgery | 1 |
| Visceral Pain, Postoperative | 1 |
| Anrikefon | 1 |
| Patient-controlled Intravenous Analgesia | 1 |
| Acute Myocardial Infarction (AMI) | 1 |
| Pain After Abdominal Surgery | 1 |
| Postoperative Ileus | 1 |
| Postoperative Analgesia | 1 |
| Sufentanil | 1 |
| Validity | 1 |
| Safety | 1 |
| Acute Myocardial Infarction | 1 |
| Multimodal Analgesia | 1 |
| Tramadol | 1 |
| Enhanced Recovery After Surgery | 1 |
| Opioid and Postoperative Pain | 1 |
| Limb Injury | 1 |
| STEMI - ST Elevation Myocardial Infarction | 1 |
| Digestive System Disease | 1 |
| Surgery | 1 |
| Pregnancy | 1 |
| Neuroaxial Analgesia Procedures | 1 |
| Morphine Adverse Reaction | 1 |
| Morphine Induced Pruritis | 1 |
| Nausea and Vomiting, Postoperative | 1 |
| Perioperative Pain Management | 1 |
| Gastreoesophageal Reflux Disease | 1 |
| Caesarean Section | 1 |
| Arthropathy of Hip | 1 |
| Hip Osteoarthritis | 1 |
| Stress | 1 |
| Early Life Stress | 1 |
| Sex Differences | 1 |
| Opioid | 1 |
| Analgesia Obstetrical | 1 |
| Post Operative Pain | 1 |
| Patient Satisfaction | 1 |
| Lung Cancer (NSCLC) | 1 |
| Lung Adenocarcinoma | 1 |
| Video Assisted Thoracic Surgery (VATS) | 1 |
| Cholecystectomy, Laparoscopic | 1 |
| Laparoscopic Hysterectomy | 1 |
| Postoperative Recovery | 1 |
| Hypoxic Ischemic Brain Injury | 1 |
| Neonatal Encephalopathy | 1 |
| Perinatal Anoxic-ischemic Brain Injury | 1 |
| Hepatectomy | 1 |
| Liver Neoplasms | 1 |
| Arthroplasties, Knee Replacement | 1 |
| Nerve Block | 1 |
| Urinary Retention Postoperative | 1 |
| Anesthesia, Spinal | 1 |
| Labor Pain | 1 |
| Neonatal Opioid Withdrawal Syndrome | 1 |
| Postsurgical Pain | 1 |
| Chronic Post-surgical Pain | 1 |
| Patient-Controlled Analgesia | 1 |
| Midline Laparotomy | 1 |
| Intrathecal Morphine | 1 |
| Intrathecal Dexmedetomidine | 1 |
| Placebo | 1 |
| Rhomboid Intercostal Sub-serratus Plane Block | 1 |
| External Oblique Intercostal Block | 1 |
| Open Nephrectomy | 1 |
| Postoperative Pain After Spinal Surgery | 1 |
| Multiple Mid-Transverse Process to Pleura | 1 |
| PCA | 1 |
| Idiopathic Scoliosis | 1 |
| Posterior Spinal Fusion | 1 |
| Post-operative Pain Management | 1 |
Sponsors
lead sponsor per trial| Lead sponsor | Trials |
|---|---|
| The Second Hospital of Anhui Medical University | 2 |
| Assistance Publique - Hôpitaux de Paris | 2 |
| Ataturk University | 2 |
| KK Women's and Children's Hospital | 2 |
| Tanta University | 2 |
| Avenue Therapeutics, Inc | 1 |
| Peking Union Medical College Hospital | 1 |
| Peking University First Hospital | 1 |
| Yingyong Zhou,MD,PhD | 1 |
| Xiangya Hospital of Central South University | 1 |
| Tongji Hospital | 1 |
| Haisco Pharmaceutical Group Co., Ltd | 1 |
| Anqing Municipal Hospital | 1 |
| Centre Hospitalier Universitaire, Amiens | 1 |
| GCS Ramsay Santé pour l'Enseignement et la Recherche | 1 |
+ 24 more sponsors in the trial list above.
By country register
A trial with sites in more than one country appears in each of those registers. CTIS does not publish a recruiting flag; its trials may also appear in the registers above.
Related compounds
Questions about Morphine trials
How many clinical trials are testing Morphine?
44 current trials in our China, Egypt, Turkey, Canada, France, Singapore, USA, Italy, Belgium, Sweden, Denmark, Poland, Switzerland, Portugal, Mexico, South Korea, Taiwan, Australia and Israel registers name Morphine as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.
Are Morphine trials recruiting patients?
Yes. 29 of the 44 trials are recruiting: 9 with sites in China, 5 with sites in Egypt, 2 with sites in Turkey, 4 with sites in Canada, 2 with sites in France, 1 with sites in Denmark, 1 with sites in Poland, 1 with sites in Switzerland, 1 with sites in Portugal, 1 with sites in South Korea, 1 with sites in Taiwan and 1 with sites in Australia. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors Morphine clinical trials?
The Second Hospital of Anhui Medical University (2), Assistance Publique - Hôpitaux de Paris (2), Ataturk University (2) and KK Women's and Children's Hospital (2), among 39 lead sponsors in total. The number in brackets is how many trials each organisation leads.
Is Morphine licensed in Ireland?
Yes. The HPRA medicines list includes 18 single-substance products containing Morphine, for example MST Continus 10 mg Prolonged-release tablets (Mundipharma Pharmaceuticals Limited). A licence does not mean a product is currently marketed or reimbursed; see each product's record.
Is there a Morphine shortage?
The registers we track list 2 entries for Morphine: US FDA: current; US FDA: resolved. Shortages are product- and country-specific; check with a pharmacist.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Morphine works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Morphine works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Morphine (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.