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Priya Life Science Compound trial record
Compound · clinical trials

Meperidine clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 3 trials in our Turkey and Singapore registers that name Meperidine as an intervention. Synced 10 Nov 2026
3Current trials
0Recruiting now
2Lead sponsors
2Country registers
At a glance

Meperidine is named as an intervention in 3 current clinical trials in our Turkey and Singapore registers. None are recruiting at the moment. The most common phase is Not applicable. The sponsor with the most trials is Istanbul Medipol University Hospital (2). The most-studied condition is Postoperative Pain After Arthroscopic Knee Surgery.

Where Meperidine is approved

All regulators →

Of the three regulators tracked here, the first to approve Meperidine was the US, on 10 Nov 1942.

USUnited States (FDA)
10 Nov 1942
Demerol
NDA021171 on Drugs@FDA
First original NDA/BLA approval
EUEuropean Union (EMA)
No centralised EU authorisation (it may be authorised nationally)
First centralised authorisation
CACanada (Health Canada)
No new-drug Notice of Compliance since 1994
First new-drug NOC

From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.

What health systems spend on Meperidine

All medicines →
ENNHS England
Not dispensed in the community in England in the last 12 months under this name
Net ingredient cost, community prescriptions
USUS Medicaid
$238k
14,901 prescriptions in 2025 · Meperidine Hydrochloride, Meperidine Hydrochloride, Demerol
-73% on 2024
Amount Medicaid reimbursed, before rebates

From NHSBSA Prescription Cost Analysis (Open Government Licence v3.0) and CMS State Drug Utilization Data. Both are gross amounts: neither system publishes its discounts or rebates per drug. Products combining several substances are not counted here.

How Meperidine works

All drug targets →
  • Mu opioid receptor agonist Agonist
    Target: OPRM1 opioid receptor mu 1
    ✓ In ChEMBL and the Guide to Pharmacology
Diseases it has been tested for in clinical trials, by furthest phase
  • Postpartum depressionPhase 2/3
  • Acute graft versus host diseasePhase 2
  • Chronic graft versus host diseasePhase 2
  • Graft versus host diseasePhase 2

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL607, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 7221, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for Meperidine

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Reference identifiers for Meperidine

ATC code
N02AB02
ChEMBL
CHEMBL607
DrugBank
DB00454
PubChem CID
4058
CAS number
57-42-1
FDA UNII
9E338QE28F
Wikidata
Q55434
Wikipedia
Pethidine

Codes that identify this medicine in other databases, from Wikidata (CC0), matched by its ChEMBL ID. The ATC code is the WHO classification of what the medicine is used for.

Trials by status

  • Not yet open267%
  • Active, closed133%

Trials by phase

  • Not applicable133%
  • Early Phase 1133%
  • Phase 2/3133%
01

Clinical trials of Meperidine

3 trials
StudyPhaseStatusLead sponsorRegisters
Adductor Canal Block Versus Parasartorial Compartment Block for Pain Relief and Recovery After Arthroscopic Knee Surgery
NCT07790393 · ClinicalTrials.gov ↗ · Postoperative Pain After Arthroscopic Knee Surgery
Not applicable Not yet open Istanbul Medipol University Hospital Turkey
Quadro-Iliac Plane Block for Pain Control After Posterior Spinal Instrumentation Surgery
NCT07711522 · ClinicalTrials.gov ↗ · Posterior Spinal Instrumentation Patients
Early Phase 1 Not yet open Istanbul Medipol University Hospital Turkey
CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery)
NCT03167905 · ClinicalTrials.gov ↗ · Depression, Postpartum, Analgesia, Obstetrical, Anesthesia, Obstetrical
Phase 2/3 Active, closed KK Women's and Children's Hospital Singapore

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Meperidine across our data

Ireland · EU · US

The same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.

Supply shortages

  • Meperidine Hydrochloride InjectionUS (FDA) · Current · updated 21 Oct 2026
03

Conditions studied with Meperidine

5 conditions
Postoperative Pain After Arthroscopic Knee Surgery1Posterior Spinal Instrumentation Patients1Depression, Postpartum1Analgesia, Obstetrical1Anesthesia, Obstetrical1
04

Sponsors

lead sponsor per trial
Lead sponsorTrials
Istanbul Medipol University Hospital2
KK Women's and Children's Hospital1
05

By country register

RegisterTrialsRecruiting
Clinical trials in Turkey20
Clinical trials in Singapore10

A trial with sites in more than one country appears in each of those registers.

06

Related compounds

07

Questions about Meperidine trials

How many clinical trials are testing Meperidine?

3 current trials in our Turkey and Singapore registers name Meperidine as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.

Are Meperidine trials recruiting patients?

Not at the moment. None of the 3 trials in our registers is recruiting; they are active but closed to enrolment, not yet open, or enrolling by invitation. Only the study team can confirm whether a patient is eligible.

Who sponsors Meperidine clinical trials?

Istanbul Medipol University Hospital (2) and KK Women's and Children's Hospital (1). The number in brackets is how many trials each organisation leads.

Is there a Meperidine shortage?

The registers we track list 1 entry for Meperidine: US FDA: current. Shortages are product- and country-specific; check with a pharmacist.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Meperidine works or whether it is effective, and it is not medical advice.

Approvals, shortages and trials, every Friday

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Meperidine works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Meperidine (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.