Ireland
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Priya Life Science Compound trial record
Compound · clinical trials

Emavusertib clinical trials

Also listed in trial records as CA-4948, AU 4948, CA4948
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 3 trials in our USA, Spain, Italy, Israel, France, Poland, Czechia, Canada and Mexico registers that name Emavusertib as an intervention. Synced 10 Nov 2026
3Current trials
3Recruiting now
2Lead sponsors
9Country registers
At a glance

Emavusertib is named as an intervention in 3 current clinical trials in our USA, Spain, Italy, Israel, France, Poland, Czechia, Canada and Mexico registers. 3 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is Curis, Inc (2). The most-studied condition is Relapsed Hematologic Malignancy.

Where Emavusertib is approved

All regulators →
USUnited States (FDA)
No FDA approval of a single-substance product in Drugs@FDA
First original NDA/BLA approval
EUEuropean Union (EMA)
No centralised EU authorisation (it may be authorised nationally)
First centralised authorisation
CACanada (Health Canada)
No new-drug Notice of Compliance since 1994
First new-drug NOC
  • 1 EU orphan designation, most recently for treatment of primary large B-cell lymphoma of immune-privileged sites (25 Jul 2024, positive)

From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.

How Emavusertib works

All drug targets →
Diseases it has been tested for in clinical trials, by furthest phase
  • B-cell chronic lymphocytic leukemiaPhase 2
  • AnemiaPhase 2
  • Myelodysplastic syndromePhase 2
  • Acute myeloid leukemiaPhase 1/2
  • Hematopoietic and lymphoid cell neoplasmPhase 1/2
  • Primary central nervous system lymphomaPhase 1/2
  • Biliary tract cancerPhase 1
  • Colorectal cancerPhase 1
  • Esophageal cancerPhase 1
  • Gastric cancerPhase 1
12 diseases in all

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL4783351, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 10152, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for Emavusertib

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting3100%

Trials by phase

  • Phase 2267%
  • Phase 1/2133%
01

Clinical trials of Emavusertib

3 trials
StudyPhaseStatusLead sponsorRegisters
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
NCT05564390 · ClinicalTrials.gov ↗ · Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm, Acute Myeloid Leukemia Post Cytotoxic Therapy
Phase 2 Recruiting National Cancer Institute (NCI) Canada, Mexico, Israel
A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants With Chronic Lymphocytic Leukemia (CLL) and Other B-cell Malignancies
NCT07271667 · ClinicalTrials.gov ↗ · Chronic Lymphocytic Leukemia, B-cell Malignancies
Phase 2 Recruiting Curis, Inc USA, Spain, Italy
CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)
NCT03328078 · Relapsed Hematologic Malignancy, Refractory Hematologic Malignancy, Relapsed Primary Central Nervous System Lymphoma
Phase 1/2 Recruiting Curis, Inc USA, France, Spain, Italy, Poland, Czechia, Israel

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Emavusertib

10 conditions
Relapsed Hematologic Malignancy1Refractory Hematologic Malignancy1Relapsed Primary Central Nervous System Lymphoma1Refractory Primary Central Nervous System Lymphoma1Chronic Lymphocytic Leukemia1B-cell Malignancies1Acute Myeloid Leukemia1Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm1Acute Myeloid Leukemia Post Cytotoxic Therapy1Acute Myeloid Leukemia, Myelodysplasia-Related1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Curis, Inc2
National Cancer Institute (NCI)1
04

By country register

RegisterTrialsRecruiting
Clinical trials in USA22
Clinical trials in Spain22
Clinical trials in Italy22
Clinical trials in Israel22
Clinical trials in France11
Clinical trials in Poland11
Clinical trials in Czechia11
Clinical trials in Canada11
Clinical trials in Mexico11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Emavusertib trials

How many clinical trials are testing Emavusertib?

3 current trials in our USA, Spain, Italy, Israel, France, Poland, Czechia, Canada and Mexico registers name Emavusertib (also registered as CA-4948) as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.

Are Emavusertib trials recruiting patients?

Yes. 3 of the 3 trials are recruiting: 2 with sites in USA, 2 with sites in Spain, 2 with sites in Italy, 2 with sites in Israel, 1 with sites in France, 1 with sites in Poland, 1 with sites in Czechia, 1 with sites in Canada and 1 with sites in Mexico. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Emavusertib clinical trials?

Curis, Inc (2) and National Cancer Institute (NCI) (1). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Emavusertib works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Emavusertib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Emavusertib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.