Multiple Mental Health ConditionsChild Mental HealthYouth Mental Health
Study summary
The Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions (CALM) Master Observational Trial is a prospective, longitudinal observational study that seeks to improve clinical care for youth with multiple mental health conditions (MMHC), also known as mental health multimorbidity in the literature. MMHC is conceptualized as the presence of two or more mental health diagnoses under the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). MMHC is common in youth seeking mental health services and is associated with less favorable outcomes and greater health services utilization. Mental health disorders also accumulate in youth over time. The Master Observational Trial (MOT) will investigate MMHC in critical developmental periods in youth and identify risk and protective factors that will provide a mechanistic understanding of how MMHC develops over time. A subset of participants will also enroll in a Deep Phenotyping Cohort, which includes enhanced clinical and cognitive assessments and multimodal neuroimaging to investigate neurobiological mechanisms underlying MMHC and identify potential biomarkers of illness complexity and progression.
In the near future, we aim to add to the current protocol to embed both a clinical trials network for youth mental health in Ontario and Calgary within the CALM study and add digital phenotyping using wearable technology to generate digital and physiological markers of MMHC. The current protocol focuses on establishing the longitudinal MOT cohort and Deep Phenotype Cohort only as a first step towards these long term CALM goals.
Eligibility
Sex
ALL
Min age
11 Years
Max age
24 Years
Healthy volunteers
No
Inclusion Criteria:
The participant must meet all of the inclusion criteria to be eligible for this research study:
* Light Phenotype Eligibility Must sign and date the informed consent form, or provide assent and have a Substitute Decision Maker provide informed consent; Aged 11-24 years old at the time of screening; Any person within age criteria who has previously sought, is seeking, or is accessing mental health services; Are able to complete assessments in English.
Deep Phenotype Eligibility Must be part of the CALM light phenotype cohort; Must sign and date the deep phenotyping informed consent form, or provide assent and have a Substitute Decision Maker provide informed consent.
Light Phenotype Caregiver Participant Eligibility:
Any caregiver of a CALM child/youth participant is eligible to participate in the study, insofar as the child/youth participant has consented to the light phenotype cohort and has agreed for their caregiver to be contacted to participate in the study; Must sign and date the informed consent form.
Deep Phenotype Caregiver Participant Eligibility:
Any caregiver of a CALM child/youth participant is eligible to participate in the study, insofar as the child/youth participant has consented to the deep phenotype cohort and has agreed for their caregiver to be contacted to participate in the study; Must sign and date the informed consent form.
Exclusion Criteria:
An individual who meets any of the following criteria will be excluded from participation in this research study:
Light Phenotype Does not provide informed consent (for those with the capacity to consent) or assent (for those who lack the capacity to consent); For those individuals who lack the capacity to consent, the inability of the parent/legal guardian to provide informed consent for the youth is also an exclusion criterion; Those who lack capacity to consent include individuals who are non-verbal or unable to speak any English.
Deep Phenotype Unable to participate in deep phenotyping protocol (e.g., MRI contraindication, uncorrected vision or hearing impairments that would interfere with data collection, unwillingness to complete assessments); No exclusion criteria are based on race, ethnicity, sex or gender.
Light Phenotype Caregiver Participant Ineligibility:
Caregivers of CALM child/youth participants are ineligible to participate in the study if:
The child/youth participant does not agree for their caregiver to be contacted to participate in the study; The child/youth participant is not participating in the light phenotype cohort; Does not provide informed consent (for those with the capacity to consent). Those who lack capacity to consent include individuals who are non-verbal or unable to speak any English.
Deep Phenotype Caregiver Participant Ineligibility:
Caregivers of CALM child/youth participants are ineligible to participate in the study if:
The child/youth participant does not agree for their caregiver to be contacted to participate in the study; The child/youth participant is not participating in the deep phenotype cohort (i.e., is only participating in the light phenotyping cohort); Does not provide informed consent (for those with the capacity to consent). Those who lack capacity to consent include individuals who are non-verbal or unable to speak any English.
Primary outcome measure(s)
Diagnostic Assessment for the Health Spectrum — Baseline and 24 months The Diagnostic Assessment for the Health Spectrum (DASH) is a semi-structured screener and interview that evaluates a broad range of psychiatric symptoms and associated symptoms. It also assesses a number of physical health symptoms. The DASH is based on the core structure of the Schedule for Affective Disorders and Schizophrenia-SADS and Kiddie-SADS, and includes features of a number of other structured interviews of psychopathology. It provides a diagnostic spectrum in addition to categorical diagnoses that are aligned to the DSM-IV and DSM-5. The completed interview yields a narrative report and summary for clinicians and researchers. There are three versions (adult, child, and parent on child) which take approximately 90-240+ minutes to complete.
Adolescent Health History — Baseline, 12 months, 24 months Youth and caregivers will be asked to self-report the presence of health conditions using the Adolescent Health History measure to indicate whether the youth has in the past or currently has any of over 40 common mental or physical health conditions listed. Youth will also be able to add up to four other conditions not listed.
Assessment of Quality of Life — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months The Assessment of Quality of Life (AQoL) measures 5 dimensions: illness, independent living, social relationships, physical senses and psychological well being. Each dimension is measured by three items (a total of 15 items).
Total scores can range from a minimum of 20 to a maximum of 99, with higher scores indicating poorer quality of life.
Brain-CODE Demographic Form — Baseline, 12 months, 24 months The Brain-CODE Demographic Form is a standard form developed by Brain-CODE to capture demographic information from participants.
Brain-CODE Medical History Form incorporating Developmental History Questionnaire (DHQ) Items — Baseline, 12 months, 24 months The Brain-CODE Medical History Form is a standard form developed by Brain-CODE to capture medical history in participants.
Canadian Health Survey on Children and Youth (CHSCY) Childhood Experiences Scale — Baseline, 12 months, 24 months The Canadian Health Survey on Children and Youth (CHSCY) Childhood Experiences Scale includes 10 items assessing youth's self-reported exposure to different forms of maltreatment by their caregivers, including physical, sexual and emotional abuse, neglect, as well as exposure to violence between caregivers. One additional item captures youth's exposure to corporal punishment. Items have been administered in population-based studies that include samples of youth and adults, as well as clinical observational studies and trials. Total scores can range from a minimum of 10 to a maximum of 50, with higher scores indicating more negative experiences.
Child and Youth Resilience Measure — Baseline, 12 months, 24 months, 36 months The Child and Youth Resilience Measure is a screening tool to explore the resources (individual, relational, communal and cultural) available to individuals that may bolster their resilience. Individuals aged 24+ will be asked to complete the Adult Resilience Measure. This measure includes multiple subscale scores assessing different domains, with scores interpreted separately by subscale.
The Columbia Suicide Severity Rating Scale — Baseline, 24 months The Columbia Suicide Severity Rating Scale is a validated and widely used rater-administered measure of suicidal ideation and behaviour, and non-suicidal self-injury. It will be administered to all participants. This measure includes multiple subscale scores assessing different domains, with scores interpreted separately by subscale.
Self-Injurious Thoughts and Behaviours Interview — Baseline, 24 months The Self-Injurious Thoughts and Behaviours Interview (SITBI) measures self-injurious thoughts and behaviors.
Canadian Health Survey on Children and Youth (CHSCY) Bullying Scale — Baseline, 12 months, 24 months The Canadian Health Survey on Children and Youth (CHSCY) Bullying Scale includes 10 items and is designed to assess youth exposure to bullying in the preceding 12 months. Items capture both the type and frequency of bullying, with types of bullying covered by the measure including verbal, physical, relational, and online forms of bullying. Response options are captured on an ordinal scale encompassing: Never, A few Times a Year, Monthly, Weekly, Daily. Total scores can range from a minimum of 10 to a maximum of 50, with higher scores indicating more experiences with bullying.
Difficulties in Emotion Regulation Scale Short Form — Baseline, 12 months, 24 months, 36 months The Difficulties in Emotion Regulation Scale Short Form is an 18-item measure used to identify emotional regulation issues. The measure covers 4 dimensions of emotional regulation: awareness and understanding of emotions; acceptance of emotions; the ability to engage in goal-directed behavior and refrain from impulsive behavior when experiencing negative emotions; and access to emotion regulation strategies perceived as effective. Total scores can range from a minimum of 18 to a maximum of 90, with higher scores indicating more difficulties with emotion regulation.
Eating Disorder Examination Questionnaire (EDE-QS) Short Form — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months The Eating Disorder Examination Questionnaire (EDE-QS) Short Form is a 12-item, self-report questionnaire capturing eating disorder symptoms. Response options are anchored on a 4-point ordinal response scale that captures symptoms over the preceding 7 days. Total scores can range from a minimum of 0 to a maximum of 36, with higher scores indicating the presence of more eating disorder symptoms.
General Anxiety Disorder-7 — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months, 42 months The General Anxiety Disorder-7 (GAD-7) measures presence and severity of Generalized Anxiety Disorder. Total scores can range from a minimum of 0 to a maximum of 21, with higher scores indicating greater presence and severity of anxiety symptoms.
General Behaviour Inventory-10 Mania — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months, 42 months The General Behaviour Inventory-10 Mania measures the presence and severity of mania. Total scores can range from a minimum of 0 to a maximum of 30, with higher scores indicating greater presence and severity of mania.
General Life Satisfaction — Baseline, 18 months, 30 months A singular question from the Canadian Social Survey - Quality of Life and Energy Consumption Behaviours measure will be administered to determine life satisfaction. Total scores can range from a minimum of 0 to a maximum of 10, with higher scores indicating greater life satisfaction.
The Goal-Based Outcome (GBO) Tool — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months The Goal-Based Outcome (GBO) Tool aims to measure the progress and outcomes of an intervention in a simple way. It can be applied in any setting and is currently available in 9 languages. The child GBO tool contains a record sheet whereby up to 3 goals with their descriptions can be written down, followed by a goal rating sheet with descriptions and a scale ranging from 0 (Goals not at all met) to 10 (Goal reached). A goal progress chart at the end can be used to rate the progress of the goal across 12 sessions.
Internalized Stigma of Mental Illness — Baseline The Internalized Stigma of Mental Illness (ISMI) scale is a questionnaire measuring self-stigma among persons with psychiatric disorders. This measure includes multiple subscale scores assessing different domains, with scores interpreted separately by subscale.
International Sedentary Assessment Tool — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months This measure consists of two parts. The first part has six items, and asks questions based on typical weekday activity in the last week. The second part also includes six items and asks questions pertaining to typical weekend activities within the last week. Higher scores equate to more sedentary behaviors in a participant.
McMaster Family Functioning Scale — Baseline, 12 months, 24 months, 36 months The McMaster Family Functioning Scale is a shorter 12-item assessment developed from The McMaster Family Assessment Device, which is a 60-item questionnaire that measures an individual's perceptions of their family. Total scores can range from a minimum of 12 to a maximum of 48, with higher scores indicating more positive perceptions of family.
Treatment Log — Baseline, 6 months, 18 months, 24 months, 30 months, 36 months, 42 months This inventory records prescribed treatment and medication, adherence and tolerability every 6 months.
Ohio State University Traumatic Brain Injury Identification Method — 3 months, 30 months The Ohio State University Traumatic Brain Injury Identification Method measures a participant's history of traumatic brain injury. Baseline and follow-up versions will be administered.
Ontario Child Health Study Emotional Behavioural Scales - Brief — Baseline, 6 months, 24 months The Ontario Child Health Study Emotional Behavioural Scales - Brief (OCHS-EBS-B) is a 25-item measurement tool for participants under the age of 18 that assesses common child/youth mental health disorders within the last 6 months. This measure includes multiple subscale scores assessing different domains, with scores interpreted separately by subscale.
Patient Global Improvement Scale — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months The Patient Global Improvement Scale evaluates all aspects of patients' health and assesses if there has been an improvement or decline in clinical status. Scores range from 0 to 7, with lower scores reflecting more positive symptoms and thus improvement in clinical status.
Patient Health Questionnaire — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months, 42 months The Patient Health Questionnaire (PHQ) is a self-administered version of the Primary Care Evaluation of Mental Disorders (PRIME-MD) diagnostic instrument for common mental disorders. The PHQ-9 is the depression module, which scores each of the 9 DSM-IV criteria as 0 (not at all) to 3 (nearly every day).
Pittsburgh Sleep Quality Index — Baseline This assessment is designed to evaluate the overall sleep quality in a clinical population. It is a 19-item self-reported questionnaire assessing seven subcategories; use of sleeping medication, subjective sleep quality, sleep latency, duration, sleep efficiency, disturbances and dysfunction during the daytime. Each subcategory ranges from scores of 0 to 3, with higher scores reflecting poorer sleep patterns.
Phlebotomy (blood) collection — Baseline, 12 months, 24 months Blood will be collected by a trained phlebotomist or research nurse with experience working with children and youth. Blood will be collected at baseline, and then annually. A maximum of 40 mL of blood will be collected per participant; however, sites may collect reduced volumes due to site-specific procedures and/or participant limitations. To ensure sufficient sample volumes for clinical and genetic/immune analyses, a minimum collection threshold will be applied to each.
Clinical testing (7-20 mL): Samples will be transferred to clinical labs for CBC, differential white cell count, HbA1C, CRP, glucose, and lipid testing.
Genetic and immune analysis (16-20 mL): Samples will be analyzed for genetic, epigenetic, and immune markers.
Sites will aim to collect the full 20 mL for both clinical and genetic testing whenever possible.
Physical Exam (Height, Weight, Body Mass Index, Waist Circumference, Neck Circumference, and Blood Pressure) — Baseline, 12 months, 24 months, 36 months A physical exam will be completed by trained research or clinical staff during the clinic visit. If the participant is unable to attend the clinic visit, research staff will use recent values from their medical record or provide instructions to the participant for measuring their height, weight, waist circumference and neck circumference at home (blood pressure will not be measured at home).
PRIME- Revised — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 42 months This is a self-administered questionnaire that is designed to assess individuals at risk for developing a psychotic disorder. It contains 12 items that assess positive symptoms on a distress scale ranging from 0 (Definitely disagree) to 6 (Definitely agree).
Revised Child Anxiety and Depression Scale — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months, 42 months The Revised Child Anxiety and Depression Scale (RCADS-25) is a self-report questionnaire that assesses symptoms of depression and anxiety in children and adolescents. This assessment captures symptoms related to generalized anxiety disorder (GAD), major depressive disorder (MDD), panic disorder, social phobia, separation anxiety disorder (SAD), and obsessive-compulsive disorder (OCD).
Saliva collection — Baseline, 12 months, 24 months Participants will be asked to provide a saliva sample to be used for genetic and epigenetic analyses. A saliva collection kit, such as that made by Oragene, will be used. Approximately 1.5 mL of saliva is provided when someone 'spits' into the collection tube. Cheek cells in saliva contain the DNA that will ultimately be extracted and processed.
The Short Warwick-Edinburgh Mental Well-being Scale — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months The Short Warwick-Edinburgh Mental Well-being Scale (SWEMWBS) uses seven statements about thoughts and feelings to monitor mental wellbeing. The seven statements are positively worded with five response categories from 'none of the time' to 'all of the time'. Children and young people are asked to describe their experiences over the past two weeks.
The Social Communication Questionnaire — Baseline The Social Communication Questionnaire (40-item parent questionnaire), which is based on the Autism Diagnostic Interview-Revised, will be used to measure current and developmental social communication deficits. This parent-report questionnaire provides information regarding social communication and repetitive behaviours present currently and from early childhood. Total scores can range from a minimum of 0 to a maximum of 39, with higher scores indicating stronger social communication.
Social Responsiveness Scale (SRS) - Short Form — Baseline, 12 months, 24 months, 30 months, 42 months The Social Responsiveness Scale measures the severity of autism symptoms in a quantitative manner, both among children affected by symptoms that fall under the spectrum of autism as well as among children in the general population. Caregivers will complete the caregiver report school short form. Total scores can range from a minimum of 16 to a maximum of 64, with higher scores indicating lower social responsiveness.
Strengths and Weaknesses of Attention-Deficit/Hyperactivity (SWAN) Disorder Symptoms and Normal Behavior scale — Baseline, 6 months, 12 months, 18 months, 24 months The Strengths and Weaknesses of Attention-Deficit/Hyperactivity Disorder Symptoms and Normal Behavior scale assesses ADHD symptoms in the clinical and non-clinical population. It includes a set of 18 questions and a child's behavior is scored on a 7-point scale with 4 (average) reflecting a normal behavior for the child's age. The first 9 items are associated with inattentive ADHD and the next 9 items are associated with hyperactive/impulsive ADHD.
Suicidal Ideation Questionnaire-Junior — Baseline, 3 months, 12 months, 24 months, 30 months, 42 months The Suicidal Ideation Questionnaire-Junior (SIQ-JR) consists of 15 items and will be completed by all youth in this study. It is designed for students in Grades 7-9. This assessment assists in informing adults/professionals of their levels of distress and suicidal intent without self-injurious behaviour. The overall aim of this measure is to assess suicidal ideation and risk.
Toronto Obsessive-Compulsive Scale - Brief — Baseline, 6 months, 12 months, 18 months, 24 months The Toronto Obsessive-Compulsive Scale (TOCS) is a 21-item parent or self-report questionnaire that assesses symptoms pertaining to Obsessive-Compulsive traits among children or adolescents. Total scores can range from a minimum of -72 to a maximum of 72, with higher scores indicating the presence of more Obsessive-Compulsive traits.
Unmet Needs Questionnaire — 12 months, 24 months, 36 months The Unmet Needs Questionnaire measures the services participants are receiving and whether their needs are being met.
Youth Life Interference Scale — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months The Youth Life Interference Scale (YLIS) is an 11-item self-report measure assessing the impact of mental health symptoms on day-to-day functioning in the past two weeks. The measure was developed in-house for the TAY study. Its focus lies on functional impairment related to anxiety and depression for youth. Total scores can range from a minimum of 0 to a maximum of 36, with higher scores indicating greater functional impairment.
Kiddie Schedule for Affective Disorders and Schizophrenia — Baseline, 24 months The Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) is a widely used structured diagnostic interview that will be administered to participants in order to determine the presence of categorical mental health diagnoses. The K-SADS will be used for participants less than 18 years of age.
Prodromal Questionnaire - Brief — Baseline This is a self-report screening measure for psychosis risk syndromes. It records psychosis-like symptoms that would have occurred over the past month. For each item in the questionnaire that is endorsed, responses range in levels of distress or impairment from a scale of 1 (strongly disagree) to 5 (strongly agree).
Structured Interview for Prodromal Symptoms (SIPS) Negative/Disorganized Subscales — Baseline The Structured Interview for Prodromal Symptoms Negative/Disorganized Subscales is a diagnostic semi-structured interview used to assess the severity of symptoms and diagnose prodromal syndromes.
The Adolescent Alcohol and Drug Involvement Scale — Baseline The Adolescent Alcohol and Drug Involvement Scale (AADIS) Revised is a self-report measure of adolescent problematic substance abuse, and will be used to quantify frequency of past-year substance use (including cannabis use). This scale also provides a numerical score derived from items related to behaviors associated with problematic use. Total scores can range from a minimum of 0 to a maximum of 84, with higher scores indicating more frequent use of substances.
Assessment of Educational Attainment — Baseline Participants will be asked to fill in a self-report questionnaire measuring educational attainment which takes about 5 minutes to complete. The revised Educational Attainment Questionnaire will assess level of education, grades and accommodations or other support at school among other education-related items. Participants fill in the Educational Attainment Questionnaire at baseline. The Educational Attainment Questionnaire is composed of several items from the School Mental Health Survey that is part of the Ontario Child Health Study, a longstanding prospective study on the overall health of children in Ontario.
Social Responsiveness Scale - Long Form — Baseline Autism spectrum symptoms will be evaluated using the long form of the Social Responsiveness Scale (SRS-2), which is a validated brief measure of autism traits consisting of 65 items. Caregivers will complete the caregiver report school version. Total scores can range from a minimum of 65 to a maximum of 260, with higher scores indicating the presence of more autism traits.
Columbia Impairment Scale — Baseline The Columbia Impairment Scale (CIS) is a 13-item self and caregiver report scale which provides a global measure of impairment in 4 major areas of functioning: interpersonal relations (family and friends), broad psychopathological domains, job or school functioning, and use of leisure time. Total scores can range from a minimum of 0 to a maximum of 52, with higher scores indicating more global impairment.
Global Functioning: Social and Role Scales - Brief — Baseline The Global Functioning: Social and Role Scales assessment measures social and role functioning through a semi-structured interview. Total scores can range from a minimum of 1 to a maximum of 10, with higher scores indicating greater functioning.
Self-report World Health Organization - Disability Assessment Schedule — Baseline The Self-report World Health Organization - Disability Assessment Schedule is a 12-item generic assessment instrument for health and disability. This tool produces standardized disability levels and profiles directly linked at the level of the concepts to the International Classification of Functioning, Disability and Health (ICF), and covers six domains of functioning: cognition, mobility, self-care, getting along, life activities, and participation. Total scores can range from a minimum of 0 to a maximum of 48, with higher scores indicating lower functioning.
Health and Social Service Utilization measure — 6 months Youth will be asked to self-report their mental health and other health and social service utilization using an adapted version of the Health and Social Service Utilization measure that has been previously used with this population, including in the current Longitudinal Youth in Transition Study at the Centre for Addiction and Mental Health (CAMH). Additional items are adapted from the Ontario Student Drug Use and Health Survey.
Transition Readiness Assessment Questionnaire — 6 months The Transition Readiness Assessment Questionnaire (TRAQ) will be used to assess the transition readiness of youth between the ages of 15 and 19 from youth to adult mental health services. Total scores can range from a minimum of 20 to a maximum of 100, with higher scores indicating greater transition readiness.
Internet Addiction Test — Baseline The Internet Addiction Test measures the presence and severity of problematic internet use across six addictive domains: Conflict, Mood Modification, Salience, Tolerance, Relapse, and Withdrawal.
Parent Child Internet Addiction Test — Baseline The Parent Child Internet Addiction Test measures the presence and severity of problematic internet use. This test is a 20-item measure asking the parent to indicate the frequency of behaviours in the child on a 6-point scale ranging from 'Does not apply' to 'Always'.
Leisure Time Questionnaire — Baseline, 6 months The Leisure Time Questionnaire is used to assess time spent in leisure activities.
MRI Scan — Baseline Youth participants enrolled in the deep phenotyping cohort will be asked to complete an MRI scan at their participating site for approximately 1 hour. Each scan will consist of high-quality T1-weighted, diffusion MRI (dMRI) and r-fMRI sequences that will be combined into a single neuroimaging output per participant.
Edinburgh Handedness Inventory - Brief — Baseline The Edinburgh Handedness Inventory (EHI) - Brief is a four-item questionnaire used to assess laterality. Youth are asked to report the dominance of the right or left hand in everyday activities. Scores range from -100 (indicating left preference) to 100 (indicating right preference).
The Snellen Chart — Baseline The Snellen Chart is an eye chart commonly used to assess visual acuity using eleven lines of block letters. Participants are asked to stand ten feet from the chart and to read the letters of each row aloud, beginning from the top row.
Toolbox Dimensional Change Card Sort Task — Baseline The Toolbox Dimensional Change Card Sort Task assesses cognitive flexibility. Youth are presented with two stimuli at the bottom of the screen and asked to sort a third stimulus presented in the middle of the screen to match one of the two stimuli at the bottom, by either colour or shape.
Toolbox Flanker Task — Baseline The Toolbox Flanker Task assesses attention and inhibitory control. Youth are presented with a target stimulus and two surrounding flanker stimuli, and are asked to indicate which direction the middle stimulus is facing (left or right); surrounding flanker stimuli may be facing in the same direction (congruent trials) or the opposite direction (incongruent trials).
Toolbox List Sorting Working Memory Test — Baseline The Toolbox List Sorting Working Memory Test assesses working memory sequencing skills. Youth are presented with animals and foods of assorted sizes both visually and auditorily, and asked to list the items presented from smallest to largest. This test is repeated using items from a single category, and items from two categories; in the latter, youth are requested to list items from one category and then the other.
Toolbox Oral Reading Recognition Task — Baseline The Toolbox Oral Reading Recognition Task assesses language exposure and reading skills. Youth are asked to pronounce visually presented letters or words.
Toolbox Pattern Comparison Processing Speed Test — Baseline The Toolbox Pattern Comparison Processing Speed Test assesses visual processing. Youth are asked to determine whether two visually presented pictures are the same.
Toolbox Picture Sequence Memory Test — Baseline The Toolbox Picture Sequence Memory Test assesses episodic memory. Youth are presented with 15 pictures demonstrating events and are asked to model those events as a series of actions using props.
Toolbox Picture Vocabulary Task — Baseline The Toolbox Picture Vocabulary Task assesses language and verbal intellect. Participants are auditorily presented with a word and asked to choose which of four visually presented pictures matches that word.
Rey Auditory Verbal Learning Test — Baseline The Rey Auditory Verbal Learning Test (RAVLT) assesses auditory learning and memory. Youth are asked to listen to and recall a list of 15 unrelated words over five learning trials. They are then presented with and asked to recall as many words from a second, distractor list of 15 words, and recall of the initial list is then assessed.
Wechsler Intelligence Test for Children-V Matrix Reasoning — Baseline This subtest of the Wechsler Intelligence Scale for Children assesses nonverbal reasoning, as well as visual intelligence, part-whole spatial reasoning, perceptual organization, attention to visual detail, and sequencing. Youth are presented with an incomplete array of visually presented stimuli, and asked to select one of four alternatives to complete the array. For participants aged 16 years or over, the Wechsler Adult Intelligence Scale-IV (WAIS-IV) version of this task will be administered.
Little Man Task — Baseline The Little Man Task (LMT) assesses visual-spatial processing, including mental rotation. Youth are asked to indicate which hand a figure is using to hold a briefcase after being presented with the figure in one of four positions.
Delay Discounting Task — 6 months Delay discounting can be defined as the depreciation of the value of a reward related to the time that it takes to be released. The task is an index of impulsive behaviour. Participants play a game in which they make a choice between an immediate small reward and a delayed larger reward.
Emotional Stroop Task — 6 months The Emotional Stroop Task is a modified version of the traditional Stroop task in which participants are required to name the ink color of words with emotional or neutral valence. This task is commonly used to measure the attentional biases toward emotional stimuli typically observed in humans.
Penn Emotion Differentiation Task — 6 months The Penn Emotion Differentiation Task measures the social cognition domain of emotion identification - the ability to decode and correctly identify facial expressions of emotion. Youth are shown 40 faces and must determine whether the emotion expressed is happiness, sadness, anger, fear, or none at all.
The Awareness of Social Inference Test (TASIT) - Short Version — 6 months The Awareness of Social Inference Test (TASIT) - Short Version measures social cognition using videos of naturalistic everyday conversations in which two actors interact. It has established ecological validity, reliability and construct validity. Alternate forms are available for re-testing.
Parental Bonding Instrument — Baseline The Parental Bonding Instrument (PBI) was designed to measure the contribution of parental behavior to the development of appropriate bonds between parents and children. This measure includes multiple subscale scores assessing different domains, with scores interpreted separately by subscale.
Personality Inventory for DSM-5 Faceted Brief Form — 6 months The Personality Inventory for DSM-5 Faceted Brief Form (PID-5-FBF) will be used to examine maladaptive personality traits. The PID-5-FBF is a 100-item self-rated personality trait assessment scale for adolescents and adults. This measure includes multiple subscale scores assessing different domains, with scores interpreted separately by subscale.
Competitive Sports Questionnaire — 6 months This is an 8-item questionnaire originally developed for the TAY study.
International Physical Activity Questionnaire — 6 months This measure is a questionnaire measuring physical activities in the last 7 days.
Pain Questionnaire — 6 months This measure assesses types of pain and frequency, and the impact of pain on 5-point Likert scales. For each pain item the participant needs to indicate if pain can be explained by a physical accident or diagnosed medical condition.
Puberty Development Scale — 6 months This scale contains five items, with the last two items being different for males and females. It assesses the presence of developmental changes associated with puberty. Total scores can range from a minimum of 5 to a maximum of 20, with higher scores indicating the presence of more developmental changes.
Social Media Addiction Questionnaire — Baseline The Social Media Addiction Questionnaire (SMAQ) is comprised of questions adapted from the Ontario Student Drug Use and Health Survey. These questions will be used to collect information on screen time use, problematic social media use and video game use, respectively, as reported by the youth participant. Total scores can range from a minimum of 6 to a maximum of 36, with higher scores indicating more problematic use of social media.
Acculturation Questionnaire — 6 months The Acculturation Questionnaire will be used to measure speaking and reading skills in English and language preference. This measure includes multiple subscale scores assessing different domains, with scores interpreted separately by subscale.
Mexican American Cultural Values Scale — 6 months The Mexican American Cultural Values Scale (50 items) is used to assess family values of individuals from diverse cultural backgrounds. Total scores can range from a minimum of 50 to a maximum of 250, with higher scores indicating less adherence to the outlined cultural values.
Multigroup Ethnic Identity-Revised — 6 months The Multigroup Ethnic Identity-Revised will be used to measure cultural affiliation. This measure contains 6 items that can be rated on a five-point scale from strongly disagree to strongly agree. Total scores can range from a minimum of 6 to a maximum of 24, with higher scores indicating stronger cultural affiliation.
Vancouver Index of Acculturation - Short — 6 months The Vancouver Index of Acculturation - Short will be used to measure acculturation with 20 items that can be rated from disagree to agree on a 9-point scale. Total scores can range from a minimum of 10 to a maximum of 90, with higher scores indicating greater acculturation.
Parental Monitoring — 6 months Family and social influences including parental monitoring and interactions with family members will be measured using the Parental Monitoring questionnaire. Total scores can range from a minimum of 5 to a maximum of 25, with higher scores indicating higher parental involvement.
Prosocial Scale from the Strengths and Difficulties Questionnaire — 6 months Family and social influences including prosocial behaviors and interactions with family members will be measured using the Prosocial Scale. Total scores can range from a minimum of 0 to a maximum of 10, with higher scores indicating more prosocial behaviors.
Conflict Behavior Questionnaire — 6 months Family and social influences including interactions with family members will be measured using the Conflict Behavior Questionnaire. Total scores can range from a minimum of 0 to a maximum of 20, with higher scores indicating the presence of more conflict-related behaviors.
Gender Dysphoria Questionnaire for Adolescents and Adult — 6 months In addition to self-reported gender obtained using the demographic protocol, gender expression will be measured using the Gender Dysphoria Questionnaire for Adolescents and Adults. Total scores can range from a minimum of 27 to a maximum of 135, with higher scores indicating greater satisfaction and less gender-related distress.
Personal Attributes Questionnaire — 6 months In addition to self-reported gender obtained using the demographic protocol, gender identity variability will be measured using the Personal Attributes Questionnaire. Total scores can range from a minimum of 0 to a maximum of 96, with higher scores indicating stronger self-perceptions of gender attributes.
Adverse Life Events Scale — 6 months Life events and current life stress will be assessed in all participants below age 18 using The Adverse Life Events Scale. Total scores can range from a minimum of 0 to a maximum of 25, with higher scores indicating more adverse life events and/or related stress.
Childhood Trauma Questionnaire - Short Form — 6 months All participants will be administered the Childhood Trauma Questionnaire - Short Form to identify traumatic childhood conditions. Total scores can range from a minimum of 28 to a maximum of 125, with higher scores indicating greater exposure to traumatic childhood conditions.
Connor-Davidson Resilience Scale — 6 months Individual resilience in the face of stress will be measured using a brief, two-item version of the Connor-Davidson Resilience Scale. Total scores can range from a minimum of 0 to a maximum of 8, with higher scores indicating higher resilience.
Everyday Discrimination Scale — 6 months Lifetime discriminatory experiences will be assessed in all participants using a Canadian adaptation of the Everyday Discrimination Scale. Total scores can range from a minimum of 5 to a maximum of 25, with higher scores indicating greater discriminatory experiences.
Life Events Checklist — 6 months The Life Events Checklist (LEC) is designed to screen for potentially traumatic experiences that may contribute to psychological distress. Participants aged 18 and above will be administered the Life Events Checklist.
Inventory for School Risk and Protective Factors — 6 months All participants' school environments will be characterized using the Inventory for School Risk and Protective Factors measure from the ABCD study. Total scores can range from a minimum of 6 to a maximum of 24, with higher scores indicating greater protective factors.
Neighbourhood Safety and Crime Scale — 6 months In the proximal social environment, neighbourhood safety will be measured using a three-item Neighbourhood Safety and Crime Scale. Total scores can range from a minimum of 3 to a maximum of 15, with higher scores indicating lower perceived neighbourhood safety.
3-Digit Postal Codes — Baseline 3-digit postal codes of participants (collected as part of routine demographic data) will be used to obtain census-based neighbourhood-level marginalization data; this will allow each participant's neighbourhood to be characterized by the level of social and economic marginalization as well as ethnic concentration. At the time of cohort entry, the first 3 digits of each participant's postal code are collected based on the participant's residential address. Any change in a participant's residential address will also be recorded during assessment periods during the study to account for changes in exposure to socio-environmental factors.
Parent General Behaviour Inventory-10 Mania — Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months, 42 months Caregivers will complete the Parent General Behaviour Inventory-10 Mania, which measures the presence and severity of mania. Total scores can range from a minimum of 0 to a maximum of 30, with higher scores indicating greater presence and severity of mania.
Video Game Addiction Questionnaire — Baseline The Video Game Addiction Questionnaire (VGAQ) is comprised of questions adapted from the Ontario Student Drug Use and Health Survey. These questions will be used to collect information on screen time use, problematic social media use and video game use, respectively, as reported by the youth participant. Total scores can range from a minimum of 6 to a maximum of 36, with higher scores indicating more problematic use of video games.
Student Adaptation to College Questionnaire — Baseline The Student Adaptation to College Questionnaire (SACQ) is a self-report questionnaire measuring educational attainment. Participants attending post-secondary school will also be asked to complete the SACQ. Total scores can range from a minimum of 67 to a maximum of 603, with higher scores indicating better overall adjustment to college life.
Trial sites (6)
Facility
City
Region
Status
University of Calgary
Calgary
Alberta
Recruiting
McMaster Children's Hospital, Hamilton Health Sciences
Hamilton
Ontario
Recruiting
Children's Hospital of Eastern Ontario Research Institute
Ottawa
Ontario
Recruiting
The Royal Ottawa Mental Health Centre
Ottawa
Ontario
Recruiting
The Hospital for Sick Children
Toronto
Ontario
Recruiting
Centre for Addiction and Mental Health (CAMH)
Toronto
Ontario
Recruiting
More Centre for Addiction and Mental Health trials in Canada
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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