A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

NCT07481630 · tracked via the Priya Life Science Canada tracker

Sponsor

Novo Nordisk A/S

Phase

Phase 3

Started

2026-04-13

Last updated

2026-07-09

Condition(s) studied

ObesityKnee Osteoarthritis (OA)

Investigational drug(s) / intervention(s)

NNC0487-0111 →Placebo (matched to NNC0487-0111 )

NNC0487-0111: NNC0487-0111 dose level 1 and dose level 2 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.

Placebo (matched to NNC0487-0111 ): Placebo matched to NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.

Study summary

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and knee osteoarthritis. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Key inclusion Criteria: * Male or female (sex at birth). * Age 18 years or above at the time of signing the informed consent. * Clinical diagnosis of knee osteoarthritis (American College of Rheumatology criteria) with radiographic changes (Kellgren Lawrence (KL) grades 2 to 3 as per central reading) in target knee. Target knee joint is defined as most symptomatic knee at screening. If pain in knees is equal, the target knee joint will be the dominant leg. * Symptomatic knee OA with first appearance of pain in the target knee more than (\>) 90 days prior to screening and pain in the target knee for \> 15 days over the prior 30 days. * Willingness to complete a 72-hour washout period of analgesics before all visits involving WOMAC Osteoarthritis Index NRS 3.1 (24-hour) (WOMAC) questionnaire (acetaminophen 4 gram (g)/day is allowed as rescue medication up until 24 hours before those visits). Exclusion Criteria: * Glycated haemoglobin more than or equal to (≥) 6.5% \[(48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening. * Any joint prosthesis or joint replacement in target knee. * Arthroscopy or injections into target knee within the last 90 days prior to screening. * Any other joint disease in target knee including gout and pseudogout.

Primary outcome measure(s)

Relative change in body weight — From baseline (week 0) to (week 80)
Measured as percentage (%) of body weight.
Change in WOMAC Osteoarthritis Index NRS 3.1 (24-hour) (WOMAC) pain score — From baseline (week 0) to (week 80)
Measured as score on a scale. Western Ontario and McMaster Universities Arthritis Index (WOMAC) measures symptoms in the areas of pain, stiffness, and physical function. The measure consists of 24 items yielding 3 subscale scores and 1 total score. WOMAC raw scores are transformed to a standardised 0 to 100 score range. Higher scores indicate worse pain, stiffness, physical function, and overall osteoarthritis- related disability.

Trial sites (82)

Facility	City	Region	Status
Arizona Research Center, Inc.	Phoenix	Arizona	Recruiting
Diablo Clinical Research, Inc.	Walnut Creek	California	Recruiting
Chase Medical Research LLC	Hamden	Connecticut	Recruiting
Chase Medical Research LLC	Waterbury	Connecticut	Recruiting
Zenith clinical research	Hollywood	Florida	Recruiting
CNS Healthcare	Jacksonville	Florida	Recruiting
Angels Clinical Research Institute	Miami Lakes	Florida	Recruiting
Hope Clin Res & Wellness	Conyers	Georgia	Recruiting
CenExel iResearch, LLC	Decatur	Georgia	Recruiting
Elite Clinical Trials	Blackfoot	Idaho	Recruiting
MedVadis Research Watertown	Waltham	Massachusetts	Recruiting
Jubilee Clinical Research, Inc.	Las Vegas	Nevada	Recruiting
Great Lakes Medical Research	Westfield	New York	Recruiting
Accellacare and KDCILM, LLC	Wilmington	North Carolina	Recruiting
Coastal Carolina Res Ctr	North Charleston	South Carolina	Recruiting
VIP Trials_San Antonio	San Antonio	Texas	Recruiting
Charlottesville Med Research	Charlottesville	Virginia	Recruiting
Health Res of Hampton Roads	Newport News	Virginia	Recruiting
Northwest Clinical Research Center	Bellevue	Washington	Recruiting
Emeritus Research Sydney	Botany	New South Wales	Recruiting
Momentum Clinical Research Darlinghurst	Darlinghurst	New South Wales	Recruiting
Kolling Institute	St Leonards	New South Wales	Recruiting
Heart of Australia	Chelmer	Queensland	Recruiting
Coastal Digestive Health	Maroochydore	Queensland	Recruiting
UMHAT Sveti Georgi EAD, Plovdiv	Plovdiv	Bulgaria	Recruiting
MC Dr. Atanasov EOOD	Sofia	Bulgaria	Recruiting
MC Excelsior OOD	Sofia	Bulgaria	Recruiting
UMHAT Tsaritsa Yoanna - ISUL EAD, Orthopaedics and Traumatology	Sofia	Bulgaria	Recruiting
MMA MHAT - Sofia, Rheumatology clinic	Sofia	Bulgaria	Recruiting
UMHAT Sveti Ivan Rilski EAD, Rheumatology	Sofia	Bulgaria	Recruiting
Laser Rejuvenation Clinics Inc.	Calgary	Alberta	Recruiting
Dawson Clinical Research	Guelph	Ontario	Recruiting
Hamilton Medical Rsrch Grp	Hamilton	Ontario	Not Yet Recruiting
Centre de Recherche Musculo	Trois-Rivières	Quebec	Recruiting
Alpha Recherche Clinique - Lebourgneuf	Québec	Canada	Recruiting
Aarhus Universitetshospital - Klinik for Led og bindevævssygdomme	Aarhus N	Denmark	Recruiting
Frederiksberg Hospital - Parker Institutet (Artrose)	Frederiksberg	Denmark	Recruiting
Sanos Clinic - Herlev	Herlev	Denmark	Recruiting
University General Hospital Attikon General Hospital Of West Attica H Agia Varvara - 2nd dept of Internal medicine	Chaïdári	Attica	Recruiting
Laiko General Hospital Of Athens - 1st department of Internal Medicine	Athens	Greece	Recruiting

+ 42 more sites — see the full list on the official registry below.

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07481630 on ClinicalTrials.gov ↗ ← All trials in Canada