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Clinical Trials in Canada / NCT07595549
Recruiting Phase 3

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

NCT07595549 · tracked via the Priya Life Science Canada tracker
Sponsor
Pfizer
Phase
Phase 3
Started
2026-06-10
Last updated
2026-09-28

Condition(s) studied

ObesityOverweight and/or ObesityOverweight

Investigational drug(s) / intervention(s)

PF-08653944 →Placebo

PF-08653944: By Subcutaneous Injection

Placebo: By Subcutaneous Injection

Study summary

The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes.

About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe.

People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Aged ≥18 years. * BMI of: ≥30 kg/m2 or ≥27.0 kg/m2 to \<30.0 kg/m2 and must have at least 1 of the following weight-related co-morbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or T2D. Exclusion Criteria: * Have a self-reported body weight change greater than 5% within 90 days prior to Screening. * Diagnosis of type 1 diabetes or any other form of diabetes other than T2D. * History of acute or chronic pancreatitis. * Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2).

Primary outcome measure(s)

Trial sites (58)

FacilityCityRegionStatus
San Fernando Valley Health Institute Canoga Park California Recruiting
Headlands Research California, LLC Escondido California Recruiting
ImmuniMet, LLC Modesto California Recruiting
Clinical Trials Research Sacramento California Recruiting
University Clinical Investigators, Inc. Tustin California Recruiting
Diablo Clinical Research, Inc. Walnut Creek California Recruiting
Southern California Retina Specialists West Hills California Recruiting
Nature Coast Clinical Research Crystal River Florida Recruiting
West Coast Eye Institute Lecanto Florida Recruiting
South Broward Research Miramar Florida Recruiting
Suncoast Clinical Research, Inc. New Port Richey Florida Recruiting
West Coast Medical Associates New Port Richey Florida Recruiting
Center for Diabetes, Obesity and Metabolism Inc Pembroke Pines Florida Recruiting
Cedar Crosse Research Center Chicago Illinois Recruiting
Northwestern University Chicago Illinois Recruiting
Endeavor Health - Family Medicine Administration Evanston Illinois Recruiting
Endeavor Health- Endocrinology Research Skokie Illinois Recruiting
MediSphere Medical Research Center, LLC Evansville Indiana Recruiting
Monroe Biomedical Research Louisville Kentucky Recruiting
Ascension Saint Agnes Heart Care Baltimore Maryland Recruiting
Aa Mrc Llc Flint Michigan Recruiting
University Of Nebraska Medical Center Omaha Nebraska Recruiting
Albuquerque Clinical Trials, Inc. Albuquerque New Mexico Recruiting
Weill Cornell Medicine - Comprehensive Weight Control Center New York New York Recruiting
Rochester Clinical Research, LLC Rochester New York Recruiting
Medication Management, LLC Greensboro North Carolina Recruiting
Accellacare - Wilmington Wilmington North Carolina Recruiting
Jeffrey Coleman, OD Wilmington North Carolina Recruiting
Midwest Eye Center Cincinnati Ohio Recruiting
Velocity Clinical Research, Mt. Auburn Cincinnati Ohio Recruiting
PlanIt Research, LLC (Monitoring Room) Houston Texas Recruiting
PlanIt Research, LLC Houston Texas Recruiting
VIP Trials San Antonio Texas Recruiting
York Clinical Research, LLC Norfolk Virginia Recruiting
Saraiva & Berlinger Ltda EPP Instituto de Pesquisa Clínica de Campinas Campinas São Paulo Recruiting
Fundação Faculdade Regional de Medicina de São José do Rio Preto São José do Rio Preto São Paulo Recruiting
CEPIC - Centro Paulista de Investigação Clínica São Paulo Brazil Recruiting
Hospital das Clínicas da Faculdade de Medicina da USP São Paulo Brazil Recruiting
Ocean West Research Clinic Surrey British Columbia Recruiting
GA Research Associates Ltd. Moncton New Brunswick Recruiting

+ 18 more sites — see the full list on the official registry below.

More Pfizer trials in Canada

Safety and Efficacy Study of PF-06835375 in Primary Immune Thrombocytopenia Recruiting
A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B Active, not recruiting
A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine Recruiting
Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC Active, not recruiting
A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30) Active, not recruiting

Other trials for the same condition

A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight Active, not recruiting
STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss Active, not recruiting
Magnetic Gastro-Ileal or Gastro-Jejunal Diversion Study ("MGI/MGJ Study") Active, not recruiting
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes Recruiting
MagDI Canada Study Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07595549 on ClinicalTrials.gov ↗ ← All trials in Canada