Longitudinal Study for Central Nervous System Vasculitis

NCT05734404 · tracked via the Priya Life Science Canada tracker

Sponsor

University of Pennsylvania

Phase

Observational

Started

2023-03-01

Last updated

2026-01-23

Condition(s) studied

Central Nervous System VasculitisCNS VasculitisCNSVVasculitis

Study summary

Primary central nervous system vasculitis (CNSV) is a potentially fatal, single-organ vasculitis that often involves a spectrum of neurologic complications, including strokes, cognitive and speech impairment, visual loss, dementia, and encephalopathy. The purpose of this study is to establish a research cohort to investigate the disease process, treatments, and patient outcomes in CNSV.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: i. Diagnostic criteria for CNSV 1. The presence of an acquired and otherwise unexplained neurologic deficit 2. The presence of either classic angiographic or histopathologic features of angiitis in the CNS 3. No evidence of systemic vasculitis or any condition that could cause the angiographic or pathologic features ii. ≥18 years of age Exclusion Criteria: i. Unwilling to sign informed consent.

Primary outcome measure(s)

Evaluate the pathogenesis of central nervous system vasculitis using disease history. — Study completion; from baseline through month 36.
To study the manner of development of disease in patients affected with central nervous system vasculitis.

Trial sites (6)

Facility	City	Region	Status
Mayo Clinic	Rochester	Minnesota	Recruiting
Cleveland Clinic	Cleveland	Ohio	Recruiting
University of Pennsylvania	Philadelphia	Pennsylvania	Recruiting
Vanderbilt University	Nashville	Tennessee	Recruiting
St. Joseph's Healthcare	Hamilton	Canada	Recruiting
University of Toronto/Sinai Health	Toronto	Canada	Recruiting

More University of Pennsylvania trials in Canada

Longitudinal Study for Eosinophilic Granulomatosis With Polyangiitis Recruiting

A Randomized Multicenter Study for Isolated Skin Vasculitis Recruiting

Abatacept for the Treatment of Giant Cell Arteritis Recruiting

One-Time DNA Study for Vasculitis Recruiting

HBRN: Immune Regulation and Costimulation in Natural History of Chronic Hepatitis B Active, not recruiting

Other trials for the same condition

The RheumSafer Study: Improving Medication Appropriateness in People With Rheumatic Conditions Recruiting

Study to Evaluate Avacopan in Combination With a Rituximab or Cyclophosphamide-containing Regimen, in Children From 6 Years to < 18 Years of Age With AAV. Active, not recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05734404 on ClinicalTrials.gov ↗ ← All trials in Canada