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Compound · clinical trials

Procarbazine hydrochloride clinical trials

Also listed in trial records as Benzamide, Monohydrochloride (9CI), Matulane, Natulan, Natulanar, Natunalar, NCI C01810, NCIC01810, P-Toluamide, Monohydrochloride (8CI), Ro 4 6467/1
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 2 trials in our Egypt, Germany, France, Italy, Netherlands, Belgium, Poland, Portugal, Canada, Mexico and Israel registers that name Procarbazine hydrochloride as an intervention. Synced 2 Oct 2026
2Current trials
1Recruiting now
2Lead sponsors
11Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from ClinicalTrials.gov registry records · Last verified · Editorial standards
At a glance

Procarbazine hydrochloride is named as an intervention in 2 current clinical trials in our Egypt, Germany, France, Italy, Netherlands, Belgium, Poland, Portugal, Canada, Mexico and Israel registers. 1 is recruiting patients now. All registered phases are Phase 3. The sponsor with the most trials is European Organisation for Research and Treatment of Cancer - EORTC (1). The most-studied condition is Lymphoma.

Where Procarbazine hydrochloride is approved

All regulators →

Of the three regulators tracked here, the first to approve Procarbazine hydrochloride was the US, on 22 Jul 1969.

USUnited States (FDA)
22 Jul 1969
Matulane
NDA016785 on Drugs@FDA
First original NDA/BLA approval
EUEuropean Union (EMA)
No centralised EU authorisation (it may be authorised nationally)
First centralised authorisation
CACanada (Health Canada)
No new-drug Notice of Compliance since 1994
First new-drug NOC

From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.

What health systems spend on Procarbazine hydrochloride

All medicines →
ENNHS England
£3k
8 items dispensed, Aug 2025 to Jul 2026
-38% on the previous 12 months
Net ingredient cost, community prescriptions
USUS Medicaid
$1.2m
292 prescriptions in 2025 · Matulane
+10% on 2024
Amount Medicaid reimbursed, before rebates

From NHSBSA Prescription Cost Analysis (Open Government Licence v3.0) and CMS State Drug Utilization Data. Both are gross amounts: neither system publishes its discounts or rebates per drug. Products combining several substances are not counted here.

How Procarbazine hydrochloride works

All drug targets →
Diseases it has been tested for in clinical trials, by furthest phase
  • Anaplastic oligoastrocytomaPhase 3
  • Anaplastic oligodendrogliomaPhase 3
  • Diffuse large B-cell lymphoma of the central nervous systemPhase 3
  • Grade III gliomaPhase 3
  • Low grade gliomaPhase 3
  • Low-grade astrocytomaPhase 3
  • Malignant gliomaPhase 3
  • Non-Hodgkin lymphomaPhase 3
  • OligodendrogliomaPhase 3
  • Primary central nervous system lymphomaPhase 3
15 diseases in all

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL1321, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3), ligand 7278, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Trials by status

  • Recruiting150%
  • Active, closed150%

Trials by phase

  • Phase 32100%
01

Clinical trials of Procarbazine hydrochloride

2 trials
StudyPhaseStatusLead sponsorRegisters

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Procarbazine hydrochloride

2 conditions
Lymphoma1Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v81
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
European Organisation for Research and Treatment of Cancer - EORTC1
National Cancer Institute (NCI)1
04

By country register

RegisterTrialsRecruiting
Clinical trials in Egypt21
Clinical trials in Germany10
Clinical trials in France10
Clinical trials in Italy10
Clinical trials in Netherlands10
Clinical trials in Belgium10
Clinical trials in Poland10
Clinical trials in Portugal10
Clinical trials in Canada11
Clinical trials in Mexico11
Clinical trials in Israel11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Procarbazine hydrochloride trials

How many clinical trials are testing Procarbazine hydrochloride?

2 current trials in our Egypt, Germany, France, Italy, Netherlands, Belgium, Poland, Portugal, Canada, Mexico and Israel registers name Procarbazine hydrochloride (also registered as Monohydrochloride (9CI)) as a drug or biological intervention, as of the registry sync on 2 October 2026. Completed and withdrawn studies are not counted.

Are Procarbazine hydrochloride trials recruiting patients?

Yes. 1 of the 2 trials is recruiting: 1 with sites in Egypt, 1 with sites in Canada, 1 with sites in Mexico and 1 with sites in Israel. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Procarbazine hydrochloride clinical trials?

European Organisation for Research and Treatment of Cancer - EORTC (1) and National Cancer Institute (NCI) (1). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Procarbazine hydrochloride works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Procarbazine hydrochloride works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Procarbazine hydrochloride (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 2 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.