Clinical trial register · Italy

Clinical Trials in Naples, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Italy and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

Download CSV

Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 6778 matching records held by the registry are in this view. Synced 08 Oct 2026, 03:19 UTC

6778

Studies in scope

all four open statuses

4069

Recruiting now

open to new participants

1018

Lead sponsors

across recruiting studies

Top sites

Milan 2843 Bologna 1305 Roma 1274 Naples 984 Rome 967

Trials with a site in Naples

Status

Study

Lead sponsor

Phase

Enrol

Sites in Italy

Start

Recruiting

Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.

NCT05948943Lymphatic Malformations

DrugAlpelisib

Novartis Pharmaceuticals

Phase 2/3

232

Bologna, Milan, Roma, Torino, Naples

2023-11-24

Recruiting

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

NCT06103864Breast Cancer

DrugsDato-DXd·Durvalumab·Nab-paclitaxel·Gemcitabine

AstraZeneca

Phase 3

625

Bergamo, Empoli, Milan, Modena, Naples, Padova, Reggio Emilia, Roma

2023-11-23

Active, closed

Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents

NCT06120491Metastatic Castration-Sensitive Prostate Cancer

DrugsSaruparib·Zytiga·Xtandi·Abiraterone acetate

AstraZeneca

Phase 3

1,898

Bari, Genoa, Meldola, Milan, Naples, Padova, Rome, Rozzano

2023-11-21

Recruiting

Naples Federico II Intensive Cardiac Care Unit Registry (Naples FED2-ICCU Registry)

NCT06162247Acute Cardiovascular Disease, Acute Coronary Syndrome, Acute Heart Failure, Cardiogenic Shock

Federico II University

Observational

5,000

Naples

2023-11-20

Recruiting

CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine

NCT06158698Cardiomyopathies, Myocarditis, Inflammatory Cardiomyopathy, Heart Failure

DrugColchicine

Niguarda Hospital

Phase 3

Naples, Bologna, Trieste, Udine, Rome, Milan, Turin, Ancona

2023-11-14

Active, closed

A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer

NCT06112379Breast Cancer

DrugsDato-DXd·Epirubicin·Xeloda·Olaparib

AstraZeneca

Phase 3

1,902

Empoli, Lucca, Milan, Modena, Naples, Padova, Province of Macerata, Roma

2023-11-14

Active, closed

A Trial to Learn if Odronextamab Combined With Chemotherapy is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Chemotherapy for Adult Participants With Follicular Lymphoma

NCT06097364Follicular Lymphoma (FL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan

Regeneron Pharmaceuticals

Phase 3

733

Meldola, Turin, Palermo, Milan, Modena, Naples, Perugia, Pisa

2023-11-14

Recruiting

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

NCT06128551Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer, Pancreatic Ductal Adenocarcinoma

DrugsElironrasib·Cetuximab

Revolution Medicines, Inc.

Phase 1/2

534

Verona, Ancona, Aviano, Meldola, Milan, Naples, Orbassano, Ravenna

2023-11-14

Active, closed

A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202

NCT06062420Neoplasms, Head and Neck

DrugsRemzistotug·Nelistotug·Belrestotug·Dostarlimab

GlaxoSmithKline

Phase 2

316

Rozzano, Bari, Bologna, Florence, Genova, Milan, Naples, Novara

2023-11-14

Active, closed

Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)

NCT06087835Chronic Kidney Disease With High Proteinuria

DrugDapagliflozin

AstraZeneca

Phase 3

1,835

Bergamo, Bologna, Foggia, Genoa, Naples, Pisa, Roma, Torino

2023-11-07

Active, closed

Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

NCT06122779Heart Failure

DrugBMS-986435

Bristol-Myers Squibb

Phase 2

227

Naples, San Donato Milanese, Pisa, Bergamo

2023-11-07

Active, closed

A Study to Evaluate Whether Participants With Melanoma Prefer Subcutaneous vs Intravenous Administration of Nivolumab and Nivolumab + Relatlimab Fixed-dose Combinations

NCT06101134Melanoma

DrugsPhesgo·Relatlimab·Opdivo·Nivolumab

Bristol-Myers Squibb

Phase 2

100

Bergamo, Meldola, Milan, Padova, Roma, Torino, Naples

2023-11-06

Recruiting

Effects of Cangrelor on MIcRovAscular Disfunction During Elective Percutaneous CORonary Intervention

NCT06089577Coronary Artery Disease

DrugCangrelor

Federico II University

Phase 4

Ferrara, Naples

2023-11-01

Recruiting

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

NCT05696626Metastatic Breast Cancer

DrugsAbemaciclib·Fulvestrant

LeonaBio

Phase 3

600

Ancona, Aviano, Candiolo, Meldola, Milan, Misterbianco, Modena, Naples

2023-10-31

Active, closed

IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma

NCT05987332Metastatic Uveal Melanoma

DrugsDarovasertib·Crizotinib·Dacarbazine·Yervoy

IDEAYA Biosciences

Phase 2/3

420

Milan, Naples, Roma, Siena

2023-10-31

Recruiting

PRO for Fighting FT in Ovarian Cancer

NCT06032975Ovarian Cancer

National Cancer Institute, Naples

Observational

240

Naples

2023-10-30

Active, closed

A Randomized, Double-blind 2-arm, Followed by an Open-label 1-arm, NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.

NCT05985915Sjogrens Syndrome

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

612

Ancona, Milan, Salerno, Naples

2023-10-27

Active, closed

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

NCT06052059Ulcerative Colitis

DrugTulisokibart

Merck Sharp & Dohme LLC

Phase 3

1,109

Monserrato, San Giovanni Rotondo, Rome, Milan, Rozzano, Rho, Naples, Palermo

2023-10-25

Recruiting

Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis

NCT06337227Atherosclerosis and Calcific Aortic Stenosis with and Without Diabetes

IRCCS SYNLAB SDN

Observational

Naples

2023-10-19

Recruiting

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

NCT06026410Solid Tumors With HRAS Alterations, Non Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC)

DrugsAdagrasib·Cabozantinib

Kura Oncology, Inc.

Phase 1

300

Bologna, Candiolo, Naples, Rozzano, Verona

2023-10-18

Active, closed

A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults

NCT06047444Chronic Migraine

DrugsDysport·Botulinum toxin type A

Ipsen

Phase 3

759

Bologna, Naples, Pavia, Pozzilli, Roma

2023-10-12

Active, closed

A Study to Evaluate First-line Ipilimumab + Nivolumab in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT06487156Non-small Cell Lung Cancer (NSCLC)

DrugsIpilimumab·Nivolumab

Bristol-Myers Squibb

Observational

404

Naples

2023-10-11

Recruiting

A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata

NCT06012240Alopecia Areata

DrugUpadacitinib

AbbVie

Phase 3

1,500

Florence, L’Aquila, Rozzano, Naples, Rome, Bologna, Brescia, Catania

2023-10-11

Active, closed

A Study to Assess Luspatercept in Lower-risk Myelodysplastic Syndrome Participants

NCT06045689Myelodysplastic Syndromes

DrugsReblozyl·Luspatercept

Bristol-Myers Squibb

Phase 3

106

Reggio Calabria, Naples, Rome, Pavia, Rozzano (MI), Novara, Turin, Florence

2023-10-05

Recruiting

Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN

NCT05755386IC-MPGN

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

106

Bari, Ranica, Brescia, Milan, Roma, Torino, Naples

2023-10-02

Recruiting

Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas

NCT06236464Squamous Cell Carcinoma of the Head and Neck, Squamous Cell Carcinoma of the Anus

National Cancer Institute, Naples

Observational

170

Bari, Naples, Novara, Pisa

2023-09-25

Recruiting

Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)

NCT06079671Locally Advanced Cervical Cancer

DrugVolrustomig

AstraZeneca

Phase 3

800

Bari, Bologna, Catania, Florence, Lecco, Milan, Monza, Naples

2023-09-22

Active, closed

Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)

NCT06088290Leiomyosarcoma

DrugsLurbinectedin·Doxorubicin

PharmaMar

Phase 3

469

Rozzano, Naples, Aviano, Bologna, Candiolo, Orbassano, Padova, Palermo

2023-09-21

Active, closed

Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC)

NCT05822752Hepatocellular Carcinoma

DrugsLivmoniplimab·Budigalimab·Sorafenib·Lenvatinib

AbbVie

Phase 2

130

Florence, Milan, Naples, Bologna, Palermo, Roma

2023-09-21

Active, closed

A Study to Learn How Safe the Study Treatment Actinium-225-macropa-pelgifatamab (BAY3546828) is, How it Affects the Body, How it Moves Into, Through and Out of the Body, and About Its Anticancer Activity in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)

NCT06052306Metastatic Castration-resistant Prostate Cancer

Bayer

Phase 1

232

Milan, Naples

2023-09-20

Recruiting

Novosyn® CHD vs Polyglactin 910 Suture to Close Wounds After Emergency or Elective Laparotomy or Laparoscopic Surgery

NCT05966961Surgical Site Infection

Aesculap AG

Observational

2,998

Naples

2023-09-18

Active, closed

An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma

NCT06047080Large B-Cell Lymphoma

DrugsPolatuzumab Vedotin·Glofitamab·Doxorubicin·Prednisone

Hoffmann-La Roche

Phase 3

1,130

Naples, Bologna, Modena, Genoa, Bergamo, Milan, Rozzano, Catania

2023-09-18

Recruiting

Low-Intensity Extracorporeal Shockwave Therapy on Penile Rehabilitation After Robot-assisted Surgical Treatment of Genitourinary Cancers

NCT06717711Prostate Carcinoma, Erectile Function, Genito Urinary Cancer

DrugTadalafil

Regina Elena Cancer Institute

Phase 3

158

Rome, Naples

2023-09-15

Active, closed

A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome

NCT05946941Sjögren's Syndrome

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

774

Brescia, Milan, Naples, Pisa, Rome, Udine

2023-09-11

Recruiting

Glycemic Response to Carbob-Enriched Pasta in Healthy and With Type 1 Diabetes People

NCT06994403Glycemic and Insulinemic Response, Type 1 Diabetes (T1D)

Federico II University

Not applicable

Naples

2023-09-04

Active, closed

The Study is Observational and Retrospective: Lifestyle, BMI and Activity Physical.

NCT06866093Breast Cancer, Body Weight Change

National Cancer Institute, Naples

Observational

112

Naples

2023-09-04

Recruiting

Neo-adjuvant Chemo and Immunotherapy in the Pre-operAtive Treatment of Locally Advanced CholangIOcarciNoma

NCT06341764Cholangiocarcinoma

DrugsTremelimumab·Durvalumab

National Cancer Institute, Naples

Phase 2

Naples, Roma, Torino, Verona

2023-09-01

Recruiting

A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis

NCT06016842Primary Biliary Cholangitis (PBC)

DrugElafibranor

Ipsen

Phase 3

276

Modena, Monza, Naples, Padova, Palermo, Pavia, Pisa, San Giovanni Rotondo

2023-08-31

Active, closed

A Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)

NCT06081894Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy

DrugAficamten

Cytokinetics

Phase 3

500

San Donato Milanese, Brescia, Florence, Foggia, Milan, Naples, Pisa, Roma

2023-08-31

Active, closed

A Study to Evaluate Long-term Safety of Ecopipam Tablets in Children, Adolescents and Adults With Tourette's Disorder

NCT06021522Tourette Syndrome

Emalex Biosciences Inc.

Phase 3

150

Genova, Naples, Roma, Catania, Milan

2023-08-16

Active, closed

Vepdegestrant (ARV-471/PF-07850327) + Palbociclib vs Letrozole + Palbociclib in ER(+)/HER2(-) Advanced Breast Cancer

NCT05909397Breast Cancer

DrugsVepdegestrant·Letrozole

Pfizer

Phase 3

Naples, Meldola, Monza

2023-08-09

Active, closed

A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression

NCT05797610Primary IgA Nephropathy

Hoffmann-La Roche

Phase 3

459

Bari, Naples, Bologna, Rome, Genoa, Pavia, Turin

2023-08-08

Recruiting

Ponatinib in Chronic Myeloid Leukemia Patients in Chronic Phase

NCT06119269Chronic Myeloid Leukemia, Chronic Phase

University of Pisa

Observational

100

Cagliari, Milan, Naples, Pisa, Roma

2023-08-02

Recruiting

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

NCT05855200Colonic Neoplasms, Neoplasms, Colon

DrugsCapeox·Dostarlimab·Folfox

GlaxoSmithKline

Phase 3

892

Cagliari, Genova, Milan, Naples, Padova, Pisa, Reggio Emilia, Roma

2023-08-01

Recruiting

Early Detection of Renal Abnormalities in Metabolically Healthy and Unhealthy Weight Excess"

NCT06338631Obesity

Istituto Auxologico Italiano

Observational

1,000

Milan, Naples

2023-08-01

Active, closed

A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

NCT05933577Melanoma

DrugsIntismeran autogene·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

1,089

Milan, Siena, Perugia, Naples

2023-07-19

Active, closed

CERvical Cancer The InFlammatory Index (CERTIFIKO)

NCT05673252Cervical Cancer

University of Campania Luigi Vanvitelli

Observational

128

Naples

2023-07-18

Recruiting

A Study to Evaluate the Safety, Efficacy, PK, PD and Immunogenicity of Cipaglucosidase Alfa/Miglustat in IOPD Subjects Aged 0 to <18

NCT04808505Glycogen Storage Disease Type II Infantile Onset

DrugsCipaglucosidase alfa·Miglustat

Amicus Therapeutics

Phase 3

Naples

2023-07-18

Recruiting

The ONCOCAMP Study

NCT06270602Oncology

National Cancer Institute, Naples

Observational

15,000

Avellino, Benevento, Caserta, Casavatore, Ercolano, Naples, Salerno

2023-07-14

Recruiting

Validation, Implementation, and Cost-analysis of a Strategy for Personalized Diagnosis of Rare Kidney Diseases

NCT06324136Chronic Kidney Diseases

Meyer Children's Hospital IRCCS

Not applicable

300

Florence, Naples, Palermo

2023-07-06

Recruiting

Assessment of the Effectiveness of the Metabolomic Approach in Screening for Endometrial Cancer

NCT06893861Endometrial Carcinoma (EC)

National Cancer Institute, Naples

Observational

3,100

Naples

2023-07-06

Active, closed

A Study of Zigakibart in Adults With IgA Nephropathy

NCT05852938IgA Nephropathy, Immunoglobulin A Nephropathy

DrugZigakibart

Novartis Pharmaceuticals

Phase 3

383

Bari, Foggia, Naples, Modena, Trieste, Pavia, Ranica

2023-07-06

Active, closed

A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

NCT05878769Chronic Obstructive Pulmonary Disease

DrugAstegolimab

Hoffmann-La Roche

Phase 3

2,000

Naples, Cona, Ferrara, Pavia, Catania, Palermo

2023-06-28

Active, closed

ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors

NCT05671510Non Small Cell Lung Cancer

DrugsGotistobart·Taxotere·Docetaxel

OncoC4, Inc.

Phase 3

630

Ancona, Bari, Bergamo, Catania, Milan, Monza, Naples, Palermo

2023-06-28

Active, closed

Durvalumab and Tremelimumab as First Line Treatment in Participants With Advanced Hepatocellular Carcinoma (HCC)

NCT05883644Advanced Hepatocellular Carcinoma

DrugsTremelimumab·Durvalumab

AstraZeneca

Phase 3

111

Milan, Naples, Padova, Pisa, Rozzano, Turin

2023-06-27

Recruiting

Evaluation of Dental and Periodontal Health After IPR in Patients in Orthodontic Treatment With Clear Aligners

NCT06685016Dentinal Hypersensitivity, Plaque, Dental, Bleeding Gum

University of Campania Luigi Vanvitelli

Not applicable

Naples

2023-06-24

Active, closed

A Study of Efficacy and Safety of Pembrolizumab Plus Enfortumab Vedotin (EV) +/- Investigational Agents in First-Line Metastatic Urothelial Carcinoma (mUC) (MK-3475-04B/KEYMAKER-U04)

NCT05845814Metastatic Urothelial Carcinoma, Urothelial Neoplasms

DrugsPembrolizumab/Vibostolimab·Pembrolizumab/Favezelimab·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 1/2

390

Naples, Milan

2023-06-23

Active, closed

A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

NCT05827016Multiple Myeloma

DrugsIberdomide·Lenalidomide

Bristol-Myers Squibb

Phase 3

1,230

Catania, Florence, Genova, Milan, Pisa, Roma, Torino, Naples

2023-06-22

Recruiting

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

NCT05789082Non-Small Cell Lung Cancer

DrugsDivarasib·Pemetrexed·Cisplatin·Carboplatin

Hoffmann-La Roche

Phase 1/2

320

Naples, Rome, Milan, Orbassano

2023-06-20

Active, closed

First CORRECT Study of Minimal Residual Disease (MRD) Detection in Colorectal Cancer

NCT06398743Colorectal Cancer

Exact Sciences Corporation

Observational

416

Rozzano, Milan, Naples

2023-06-20

Recruiting

Ganciclovir Resistant/Refractory Cytomegalovirus Infection in SOT Recipients and HSCT Patients

NCT05234723Cytomegalovirus Infections

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna, Rozzano, Palermo, Genova, Milan, Modena, Naples, Padova

2023-06-19

Recruiting

A Retrospective Study to Characterize Participants With Propionic Acidemia

NCT05769621Propionic Acidemia

ModernaTX, Inc.

Observational

Naples, Monza, Florence

2023-06-16

Recruiting

Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients

NCT05821556Adenocarcinoma of the Pancreas

DrugsValproic acid·Simvastatin·Nab-paclitaxel·Capecitabine

National Cancer Institute, Naples

Phase 2

240

Naples, Milan, Roma, Verona

2023-06-12

Recruiting

A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS

NCT06917924Amyotrophic Lateral Sclerosis (ALS)

A.O.U. Città della Salute e della Scienza

Observational

200

Milan, Naples, Torino

2023-05-20

Recruiting

A Study to Learn More About the Study Medicine Called Inotuzumab Ozogamicin (InO) in Children (1 to <18 Years) With First Relapse ALL

NCT05748171ACUTE LYMPHOBLASTIC LEUKEMIA

DrugInotuzumab Ozogamicin

Pfizer

Phase 2

100

Naples, Genoa, Monza, Rome, Catania, Padova, Pavia, Torino

2023-05-17

Recruiting

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

NCT05442567Ulcerative Colitis, Crohn's Disease

DrugVedolizumab

Takeda

Phase 3

240

Naples, Bologna, Rome, Monza, Florence, Padova

2023-05-16

Recruiting

A Study to Evaluate the Efficacy and Safety of QMF149 (Indacaterol Acetate/Mometasone Furoate) Versus Budesonide in Children From 6 to Less Than 12 Years of Age With Asthma

NCT05562466Asthma

DrugBudesonide

Novartis Pharmaceuticals

Phase 3

200

Brescia, Catania, Florence, Pavia, Roma, Naples

2023-05-11

Active, closed

A Study of HFB200603 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors

NCT05789069Renal Cell Carcinoma, Melanoma, Non Small Cell Lung Cancer, Gastric Cancer

DrugTislelizumab

HiFiBiO Therapeutics

Phase 1

Naples, Rome, Verona

2023-05-09

Active, closed

An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma

NCT05876754Cholangiocarcinoma

DrugIvosidenib

Servier Affaires Médicales

Phase 3

299

Bologna, Florence, Milan, Naples, Reggio Emilia, Roma, Rozzano, San Giovanni Rotondo

2023-05-03

Active, closed

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer

NCT05775159Hepatocellular Carcinoma, Biliary Tract Cancer

DrugsVolrustomig·Rilvegostomig·Lenvatinib·Gemcitabine

AstraZeneca

Phase 2

294

Florence, Milan, Naples, Rozzano

2023-04-24

Active, closed

Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

NCT05611931Endometrial Cancer

DrugSelinexor

Karyopharm Therapeutics Inc

Phase 3

257

Bologna, Brescia, Meldola, Milan, Monza, Naples, Padova, Pisa

2023-04-18

Active, closed

A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer

NCT05645692Urothelial Cancer

DrugsTobemstomig·Tiragolumab·Atezolizumab

Hoffmann-La Roche

Phase 2

204

Bari, Naples, Bologna, Meldola, Rome, Milan, Terni, Padova

2023-04-13

Recruiting

The Potential Role of Compounds Derived From Ultra-processed Foods in Pathogenesis of Eosinophilic Esophagitis

NCT06093204Esophagitis, Eosinophilic

Federico II University

Observational

100

Naples

2023-04-12

Active, closed

A Study Evaluating the Effect of Filgotinib in Participants With Active Axial Spondyloarthritis

NCT05785611Axial Spondyloarthritis

DrugFilgotinib

Alfasigma S.p.A.

Phase 3

495

Bologna, Naples, Palermo, Rome, Udine

2023-04-05

Active, closed

Open Label, Long-term Study Evaluating Safety and Efficacy of Subcutaneous Amlitelimab in Participants Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis

NCT05769777Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 2

999

Milan, Naples, Rome, Brescia, Vicenza

2023-04-03

Active, closed

A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

NCT05794906Biochemically Recurrent Prostate Cancer

DrugDarolutamide

Bayer

Phase 3

985

Foggia, Naples, Bologna, Modena, Reggio Emilia, Aviano, Rome, Genoa

2023-04-03

Not yet open

Predictive Biomarkers Including miRNA-based Tumor Signatures in Diffuse Large B Cell Lymphoma (R/R DLBCL) (MIMOSA)

NCT05746858Diffuse Large B Cell Lymphoma, Relapsed Non-Hodgkin Lymphoma

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Observational

300

Naples, Roma

2023-04-01

Recruiting

Multi-observational Study for the Early Identification of Autism Spectrum Disorder (ASD) and Other Neurodevelopmental Disorders (NDD) in At-risk Populations

NCT06915805Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders

Istituto Superiore di Sanità

Observational

296

Como, Milan, Naples, Rome

2023-04-01

Active, closed

Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

NCT05819359Parkinson's Disease

Bial R&D Investments, S.A.

Phase 2

237

Bologna, Brescia, Brindisi, Milan, Naples, Padova, Roma, Rozzano

2023-03-31

Active, closed

Spectral CT Protocol Optimization for Atherosclerotic Plaque CharacterizatION

NCT06886958Atherosclerotic Disease

IRCCS SYNLAB SDN

Observational

100

Naples

2023-03-31

Recruiting

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

NCT05727904Metastatic Melanoma, Unresectable Melanoma, Melanoma

DrugsLifileucel·Pembrolizumab

Iovance Biotherapeutics, Inc.

Phase 3

670

Meldola, Aviano, Naples, Pisa, Milan, Siena

2023-03-30

Recruiting

Pembrolizumab and Olaparib Treatment of Extensive Small Cell Lung Cancer (ES-SCLC)

NCT05623319SCLC,Extensive Stage

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

Phase 2

Meldola, Monza, Pesaro, Bari, Bologna, Naples, Padova, Ravenna

2023-03-27

Active, closed

A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)

NCT05714202Bladder Cancer

DrugsTAR-200·Cetrelimab

Janssen Research & Development, LLC

Phase 3

1,135

Acquaviva delle Fonti, Asti, Avellino, Castelfranco Veneto, Milan, Naples, Ravenna, Rome

2023-03-23

Recruiting

Study on the Efficacy and Tolerance of a New Anti-regurgitation Infant Formula (STELLAR)

NCT04358146Gastroesophageal Reflux in Children

United Pharmaceuticals

Not applicable

346

Naples

2023-03-17

Active, closed

Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer

NCT05445778Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer

DrugsMirvetuximab Soravtansine·Bevacizumab

AbbVie

Phase 3

520

Florence, Meldola, Genoa, Rozzano, Milan, Naples, Rome, Mirano

2023-03-15

Recruiting

Observational Study Analysing the Transcriptome and Mutational Status of Thyroid Carcinomas of Follicular Origin with Different Degrees of Malignancy

NCT06878534Thyroid Cancer

IRCCS SYNLAB SDN

Observational

Naples

2023-03-13

Active, closed

A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma

NCT05625399Melanoma

DrugsPhesgo·Relatlimab·Nivolumab

Bristol-Myers Squibb

Phase 3

579

Genova, Siena, Bari, Milan, Naples, Perugia, Roma

2023-03-06

Active, closed

A Study of 5 Years of Adjuvant Osimertinib in Completely Resected Epidermal Growth Factor Receptor Mutation (EGFRm) Non-small Cell Lung Carcinoma (NSCLC)

NCT05526755Stage II-IIIB Non-small Cell Lung Carcinoma

DrugsTagrisso·Osimertinib

AstraZeneca

Phase 2

188

Avellino, Brescia, Lecce, Milan, Naples, Palermo, Peschiera del Garda, Reggio Emilia

2023-03-06

Active, closed

A Study to Learn About a New Medicine Called Vepdegestrant (ARV-471, PF-07850327) in People Who Have Advanced Metastatic Breast Cancer

NCT05654623Advanced Breast Cancer

DrugsVepdegestrant·Fulvestrant

Pfizer

Phase 3

624

Naples, Misterbianco, Bologna, Cona, Rome, Monza, Ancona, Pisa

2023-03-03

Active, closed

DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

NCT05566795Low-grade Glioma, Rapidly Accelerated Fibrosarcoma (RAF) Altered Glioma, Pediatric Low-grade Glioma

DrugsTovorafenib·Carboplatin

Day One Biopharmaceuticals, Inc.

Phase 3

418

Milan, Roma, Torino, Bari, Florence, Genova, Naples, Padova

2023-02-27

Active, closed

A Treatment Effectiveness Study Among SLE Patients Receiving Anifrolumab in Routine Clinical Practice.

NCT05637112Systemic Lupus Erythematosus

AstraZeneca

Observational

551

Naples, Cona, Udine, Rome, Brescia, Milan, Turin, Cagliari

2023-02-27

Active, closed

Assessment of GORE® SYNECOR Biomaterial in Focused Patient Populations and Long-Term Application

NCT05094089Hernia, Ventral, Hernia Incisional, Hernia Incisional Ventral

W.L.Gore & Associates

Observational

320

Baggiovara, Naples, Roma

2023-02-24

Recruiting

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

NCT05503797Cancer Harboring BRAF Alterations, HGG, LGG, Solid Tumors

Fore Biotherapeutics

Phase 2

254

Meldola, Naples, Milan

2023-02-21

Recruiting

Post-Market Registry for the Evaluation of RefluxStop in GERD Treatment

NCT05870163Gastroesophageal Reflux Disease (GERD)

Implantica CE Reflux Ltd.

Observational

2,500

Bari, Naples

2023-02-20

Active, closed

A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A

NCT05685238Haemophilia A, Haemophilia A With Inhibitors

Novo Nordisk A/S

Phase 3

451

Rome, Florence, Milan, Naples, Roma, Torino

2023-02-13

Active, closed

A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

NCT05578976Diffuse Large B-Cell Lymphoma

DrugsEpcoritamab·Vincristine·Doxorubicin·Prednisone

Genmab

Phase 3

900

Alessandria, Bari, Brescia, Bologna, San Giovanni Rotondo, Milan, Naples, Palermo

2023-02-08

Active, closed

Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)

NCT05609968Carcinoma, Non-Small-Cell Lung

DrugsSacituzumab Govitecan·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

614

Rome, Bergamo, Milan, Naples, Florence, Peschiera del Garda, Parma

2023-02-06

Recruiting

START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer

NCT05492682Melanoma (Skin), Triple-Negative Breast Cancer, Non-Small Cell Lung Cancer, Synovial Sarcoma

DrugsCyclophosphamide·Pembrolizumab

Valo Therapeutics Oy

Phase 1

Candiolo, Milan, Naples

2023-02-02

Recruiting

Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases

NCT05545007Brain Metastases, Adult

Istituto Clinico Humanitas

Not applicable

146

Brescia, Florence, Rozzano, Milan, Naples, Rome, Terni

2023-01-31

Active, closed

Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer

NCT05563220Breast Cancer, Metastatic Breast Cancer

DrugsAlpelisib·Capivasertib·Elacestrant·Everolimus

Stemline Therapeutics, Inc.

Phase 1/2

435

Brescia, Milan, Naples, Rimini

2023-01-24

Active, closed

A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery

NCT05608291Melanoma

DrugsFianlimab·Cemiplimab·Keytruda·Pembrolizumab

Regeneron Pharmaceuticals

Phase 3

1,564

Ancona, Naples, Meldola, Milan, Bari, Cuneo, Perugia, Rome

2023-01-16

Active, closed

A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)

NCT05617677Systemic Lupus Erythematosus

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

516

Rome, Milan, Pisa, Padova, Brescia, Naples, Verona

2023-01-12

Recruiting

Endurant Stent Graft System vs Excluder Endoprothesis: ADVANCE Trial

NCT05378347Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm >= 5.5 Centimeters in Male (Disorder), Abdominal Aortic Aneurysm >= 5.0 Centimeters in Female (Disorder)

Medtronic Cardiovascular

Not applicable

600

Milan, Naples, Torino

2023-01-05

Recruiting

Tumor Antigen Discovery for Innovative Cancer Immunotherapies in HCC: from Benchside to Bedside (HepAnt)

NCT06905262Hepatocellular Carcinoma

National Cancer Institute, Naples

Observational

Naples

2023-01-02

Active, closed

Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma

NCT05678673Non-Clear Cell Renal Cell Carcinoma

DrugsSunitinib Malate·Zanzalintinib·Sunitinib·Opdivo

Exelixis

Phase 3

317

Rozzano, Candiolo, Arezzo, Bari, Brescia, Meldola, Milan, Naples

2023-01-01

Recruiting

Clinical Outcomes of Use of Olaparib in Castration Resistant Prostate Cancer

NCT06783127Prostate Cancer, Castrate Resistant Prostate Cancer, BRCA Mutation

DrugOlaparib

Santa Chiara Hospital

Observational

3,000

Naples, Trento

2023-01-01

Recruiting

AF Ablation With High Power Short Duration RF

NCT05777551Atrial Fibrillation, Catheter Ablation

Clinica Mediterranea

Observational

850

Mercogliano, Cotignola, Conegliano, Ancona, Asti, Naples, Torino

2023-01-01

Active, closed

A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease

NCT05595642Chronic Obstructive Pulmonary Disease (COPD)

DrugAstegolimab

Hoffmann-La Roche

Phase 3

1,290

Battipaglia, Naples, Ferrara, Pavia, Catania, Palermo

2022-12-29

Active, closed

Study of ONCOFID-P-B (PACLITAXEL-HYALURONIC ACID)

NCT05024773Bladder Carcinoma in Situ (CIS)

Fidia Farmaceutici s.p.a.

Phase 3

130

Bergamo, Bologna, Castelfranco Veneto, Florence, Lecce, Milan, Naples, Roma

2022-12-29

Active, closed

Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations

NCT05687266NSCLC

DrugsDato-DXd·Durvalumab·Pemetrexed·Paclitaxel

AstraZeneca

Phase 3

1,350

Florence, Lecco, Messina, Naples, Orbassano, Padova, Parma, Peschiera del Garda

2022-12-29

By invitation

Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema

NCT05396105Hereditary Angioedema, Hereditary Angioedema Type I, Hereditary Angioedema Type II, Hereditary Angioedema Types I and II

DrugDeucrictibant

Pharvaris Netherlands B.V.

Phase 2/3

150

Catania, Milan, Naples, Padova, Palermo, Roma

2022-12-28

Recruiting

Multicenter Italian Cohort Study on Tuberculosis in Pediatric Age

NCT06289660Tuberculosis Infection

Meyer Children's Hospital IRCCS

Observational

1,000

Florence, Bari, Belluno, Bologna, Genova, Milan, Modena, Naples

2022-12-22

Recruiting

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

NCT05549297Advanced Melanoma

DrugTebentafusp

Immunocore Ltd

Phase 3

540

Milan, Naples, Perugia, Roma, Siena

2022-12-19

Recruiting

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

NCT05232916Breast Cancer

Greenwich LifeSciences, Inc.

Phase 3

2,250

Bologna, Genova, Milan, Modena, Naples, Novara, Padova, Pavia

2022-12-16

Recruiting

Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemia

NCT05327894Acute Lymphoblastic Leukemia, Mixed Phenotype Acute Leukemia

DrugBlinatumomab

Princess Maxima Center for Pediatric Oncology

Phase 3

160

Florence, Naples, Roma, Torino, Trieste, Verona

2022-12-15

Recruiting

Restoring Sensitivity To Immunotherapy In Advanced Triple Negative Breast Cancer Exploiting Ceralasertib Priming Followed By Combined Durvalumab/Nab-Paclitaxel

NCT05582538Triple Negative Breast Cancer Metastatic

DrugsCeralasertib·Abraxane·Durvalumab·Nab-paclitaxel

IFOM ETS - The AIRC Institute of Molecular Oncology

Phase 2

Novara, Bergamo, Milan, Naples, Padova, Reggio Emilia

2022-12-15

Recruiting

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

NCT05624450Viral Lung Infection and Acute Respiratory Failure

DrugTozorakimab

AstraZeneca

Phase 3

3,527

Arezzo, Brescia, Naples, Roma, Rozzano, Torino

2022-12-13

Active, closed

CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)

NCT05681351Severe Hypertriglyceridemia

DrugOlezarsen

Ionis Pharmaceuticals, Inc.

Phase 3

885

Bergamo, Bologna, Caserta, Milan, Naples, Palmero, Rome

2022-12-13

Active, closed

A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer

NCT05488314Carcinoma, Non-Small-Cell Lung

DrugsCapmatinib·Amivantamab

Janssen Research & Development, LLC

Phase 1/2

Milan, Naples, Padova, Ravenna, Rome

2022-12-13

Active, closed

A Study of Botensilimab (AGEN1181) for the Treatment of Advanced Melanoma

NCT05529316Advanced Melanoma

DrugsBalstilimab·Botensilimab

Agenus Inc.

Phase 2

150

Meldola, Naples, Siena

2022-12-12

Active, closed

A Study to Determine the Efficacy and Safety of Luspatercept in Adult Participants and to Evaluate the Safety and Pharmacokinetics in and Adolescent Participants With Alpha (α)-Thalassemia

NCT05664737Anemia

DrugsReblozyl·Luspatercept

Bristol-Myers Squibb

Phase 2

189

Genova, Orbassano, Naples

2022-12-09

Active, closed

SerUM Markers in MERkel Cell Carcinoma Patients: a Longitudinal moniTorIng Study for optiMization of European Guidelines

NCT04705389Merkel Cell Carcinoma

University Hospital, Tours

Not applicable

Naples

2022-12-05

Recruiting

Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer

NCT05522660Non-Small Cell Lung Cancer, Melanoma

ETOP IBCSG Partners Foundation

Phase 3

180

Naples, Padova, Perugia, Roma, Rome, Siena

2022-11-30

Active, closed

Study to Evaluate Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) Long-term Safety and Efficacy in Subjects Without F508del

NCT05331183Cystic Fibrosis

DrugsELX/TEZ/IVA·Ivacaftor·Elexacaftor/Tezacaftor/Ivacaftor

Vertex Pharmaceuticals Incorporated

Phase 3

297

Ancona, Florence, Genova, Messina, Milan, Naples, Orbassano, Potenza

2022-11-23

Active, closed

A Phase I Trial of IMA970A Plus Montanide in Combination With Durvalumab (Anti-PD-L1)

NCT06218511Hepatocellular Carcinoma

National Cancer Institute, Naples

Phase 1

Naples

2022-11-22

Active, closed

Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis

NCT05556096Generalized Myasthenia Gravis

Alexion Pharmaceuticals, Inc.

Phase 3

260

Bergamo, Brescia, Florence, Milan, Naples, Palermo, Pisa, Roma

2022-11-21

Active, closed

A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products

NCT05476926Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Branch Retinal Vein Occlusion

DrugsVabysmo·Faricimab

Hoffmann-La Roche

Observational

6,000

Chieti, Bari, Catanzaro, Naples, Udine, Rome, Genoa, Bergamo

2022-11-21

Recruiting

A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)

NCT05562830Urothelial Carcinoma

DrugsMK-3120·Zilovertamab vedotin·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 1/2

Milan, Naples

2022-11-16

Recruiting

A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

NCT05498428Carcinoma, Non-small-Cell Lung

DrugsDirect Anticoagulant·LMWH·DOAC·Low molecular weight heparin

Janssen Research & Development, LLC

Phase 2

520

Genova, Milan, Monza, Naples

2022-11-11

Active, closed

Safety and Efficacy of FT14 Conditioning for Allogeneic HSCT in Acute Myeloid Leukemia

NCT07232953Acute Myeloid Leukaemia (AML), Hematopoietic Stem Cell Transplant (HSCT)

DrugsTreosulfan·Fludarabine

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Phase 2

Reggio Calabria, Naples, Modena, Udine, Brescia, Milan, Cuneo, Ancona

2022-11-10

Active, closed

Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis

NCT05583227Eosinophilic Esophagitis

DrugTezepelumab

AstraZeneca

Phase 3

368

Bologna, Milan, Naples, Padova, Pisa, Roma, Rozzano, Verona

2022-11-10

Recruiting

The Use of Indocyanine Green Fluorescence (ICG) During Laparoscopic Heller- Dor

NCT07181070Achalasia, Esophageal, Achalasia, Indocyanine Green (ICG), Indocyanine Green

Federico II University

Observational

Naples

2022-11-01

Recruiting

Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Inclisiran in Italy

NCT06287177Hypercholesterolemia

DrugInclisiran

Federico II University

Observational

3,000

Naples

2022-11-01

Recruiting

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

NCT05552222Multiple Myeloma

DrugsTalquetamab·Teclistamab·Daratumumab·Lenalidomide

Janssen Research & Development, LLC

Phase 3

1,590

Bergamo, Bologna, Florence, Milan, Naples, Pavia, Roma, Rozzano

2022-10-25

Recruiting

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

NCT05253651Colorectal Neoplasms

DrugsTucatinib·Herceptin·Erbitux·Avastin

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

400

Monserrato, Avellino, Rome, Tricase, Brescia, Milan, Naples, Verona

2022-10-24

Active, closed

A Study of Tirbanibulin Ointment and Diclofenac Sodium Gel for the Treatment of Adult Participants With Actinic Keratosis on the Face or Scalp

NCT05387525Keratosis, Actinic

DrugDiclofenac Sodium

Almirall, S.A.

Phase 4

447

Arezzo, Brescia, Genova, Modena, Naples, Reggio Emilia, Roma, Rozzano

2022-10-24

Active, closed

A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer

NCT05587296Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes

Bayer

Phase 3

474

Naples, Modena, Rome, Genoa, Milan, Pavia, Turin, Florence

2022-10-14

Active, closed

Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic Non-Small Cell Lung Cancer

NCT05502237Non-small Cell Lung Cancer

DrugsDomvanalimab·Zimberelimab·Nab-paclitaxel·Pemetrexed

Gilead Sciences

Phase 3

1,021

Avellino, Cremona, Genova, Milan, Naples, Pavia, Pesaro, Piacenza

2022-10-12

Recruiting

Met Non Small Cell Cancer Registry (MOMENT)

NCT05376891Cancer

EMD Serono Research & Development Institute, Inc.

Observational

700

Misterbianco, Milan, Modena, Naples, Rome, Torino, Varese

2022-10-04

Recruiting

Characterization of Cardiovascular Risk Profile and Therapeutic Management in Patients With Type 2 Diabetes Mellitus in Italy

NCT07375069Type 2 Diabetes

Federico II University

Observational

3,000

Naples

2022-10-01

Active, closed

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis

NCT05503264NMDAR Autoimmune Encephalitis, LGI1 Autoimmune Encephalitis

DrugSatralizumab

Hoffmann-La Roche

Phase 3

122

Naples, Genoa, Milan, Pavia, Palermo

2022-09-27

Recruiting

Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT05327114Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

DrugNipocalimab

Janssen Research & Development, LLC

Phase 2/3

201

Catania, Genova, Milan, Naples, Orbassano, Pavia, Roma, Rozzano

2022-09-23

Recruiting

INSIGHTFUL-FFR Clinical Trial

NCT05437900Coronary Artery Disease, Acute Coronary Syndrome

CoreAalst BV

Phase 4

2,500

Ferrara, La Spezia, Latina, Naples, Rome

2022-09-22

Active, closed

A Single Arm Trial Evaluating the Efficacy and Safety of EVX-01 in Combination With Pembrolizumab in Adults With Unresectable or Metastatic Melanoma

NCT05309421Melanoma Stage IV, Unresectable Melanoma

DrugsKeytruda·Pembrolizumab

Evaxion Biotech A/S

Phase 2

Milan, Naples

2022-09-19

Active, closed

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

NCT05462717Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma, Advanced Solid Tumor

DrugElironrasib

Revolution Medicines, Inc.

Phase 1

222

Milan, Naples, Orbassano, Pavia, Verona

2022-09-19

Active, closed

A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy

NCT05450692Advanced or Metastatic Non-Small Cell Lung Cancer

DrugsCeralasertib·Durvalumab·Docetaxel

AstraZeneca

Phase 3

594

Aviano, Livorno, Meldola, Milan, Monza, Naples, Padova, Parma

2022-09-15

Active, closed

Post-market Clinical Investigation of the SING IMT System, Model NG SI IMT 3X in Patients With End-stage Age-related Macular Degeneration

NCT04796545AMD, Age-Related Macular Degeneration

VisionCare, Inc.

Not applicable

Naples, Roma

2022-09-13

Active, closed

A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus

NCT05531565Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus

DrugLitifilimab

Biogen

Phase 2/3

450

Bologna, Brescia, Florence, Genova, Milan, Naples, Roma

2022-09-13

Recruiting

Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.

NCT05553873Myeloproliferative Disease, Inflammatory Markers

University of Milano Bicocca

Observational

500

Bari, Bologna, Brescia, Catania, Naples, Roma, Torino, Udine

2022-09-08

Recruiting

Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial

NCT05334368Hypereosinophilic Syndrome

DrugDepemokimab

GlaxoSmithKline

Phase 3

109

Bologna, Catania, Milan, Naples, Novara, Pavia, Roma, Treviso

2022-09-06

Recruiting

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

NCT05489211Endometrial Cancer, Gastric Cancer, Metastatic Castration-resistant Prostate Cancer, Ovarian Cancer

DrugsPrednisone/Prednisolone·Volrustomig·Rilvegostomig·Dato-DXd

AstraZeneca

Phase 2

454

Florence, Genova, Milan, Naples, Rome

2022-09-06

Recruiting

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

NCT05386108Breast Neoplasms, Brain Neoplasms, Neoplasms by Site, Neoplasms

DrugsElacestrant·Abemaciclib

Stemline Therapeutics, Inc.

Phase 1/2

Ancona, Candiolo, Meldola, Messina, Milan, Modena, Monza, Naples

2022-08-31

Recruiting

Asciminib Roll-over Study

NCT04877522Chronic Myelogenous Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive

DrugsAsciminib single agent·Bosutinib·ABL001·Nilotinib

Novartis Pharmaceuticals

Phase 4

347

Milan, Roma, Naples

2022-08-30

Recruiting

A Phase 2 Study of ACR-368 in Endometrial Adenocarcinoma

NCT05548296Endometrial Adenocarcinoma

DrugGemcitabine

Acrivon Therapeutics

Phase 2

350

Aviano, Catania, Milan, Naples, Pieve Emanuele, Roma, Turin

2022-08-29

Active, closed

Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials

NCT05492578Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 2/3

1,856

Milan, Rozzano, Naples, Rome, Turin, Bologna, Catania, Chieti

2022-08-22

Active, closed

A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)

NCT05327530Locally Advanced or Metastatic Urothelial Carcinoma

DrugsAvelumab·Sacituzumab Govitecan

EMD Serono Research & Development Institute, Inc.

Phase 2

256

Bologna, Florence, Forlì, Milan, Misterbianco, Naples, Padova, Pisa

2022-08-17

Active, closed

An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice

NCT05494606Ulcerative Colitis

AbbVie

Observational

785

Castellana Grotte, Rozzano, Milan, Naples, Rome, Negrar, Palermo, Pisa

2022-08-15

Active, closed

A Study of Ceralasertib Monotherapy and Ceralasertib Plus Durvalumab in Patients With Melanoma and Resistance to PD-(L)1 Inhibition

NCT05061134Melanoma

DrugsCeralasertib·Durvalumab

AstraZeneca

Phase 2

194

Candiolo, Milan, Naples, Padova, Perugia, Roma, Siena

2022-08-11

Active, closed

A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow

NCT05330325SGA, Turner Syndrome, Noonan Syndrome, ISS

DrugsNorditropin·Somapacitan

Novo Nordisk A/S

Phase 3

412

Milan, Florence, Genova, Naples, Roma, Rome

2022-08-10

Active, closed

Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome

NCT05349214Sjogren Syndrome

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

506

Ancona, Milan, Salerno, Udine, Naples

2022-08-04

Active, closed

Evaluation of Rifaximin SSD for Delaying Encephalopathy Decompensation in Patients With Cirrhosis

NCT05297448Hepatic Encephalopathy

DrugRifaximin SSD

Bausch Health Americas, Inc.

Phase 3

466

Milan, Naples, Novara, Palermo, Rozzano

2022-08-03

Active, closed

Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment

NCT05261399Carcinoma, Non-Small-Cell Lung

DrugsSavolitinib·Tagrisso·Osimertinib·Pemetrexed

AstraZeneca

Phase 3

341

Avellino, Aviano, Catania, Meldola, Milan, Modena, Monserrato, Naples

2022-08-03

Recruiting

A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation

NCT05410145KRAS P.G12C

DrugsD3S-001·Cetuximab·Pemetrexed·Cisplatin

D3 Bio (Wuxi) Co., Ltd

Phase 1/2

442

Candiolo, Milan, Naples, Rome, Siena

2022-08-03

Active, closed

A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes

NCT05433584Type 2 Diabetes

DrugTirzepatide

Eli Lilly and Company

Phase 4

780

Bari, Naples, Milan, Moncalieri, Olbia, Palermo, Pisa, Catanzaro

2022-08-01

Recruiting

Comparison Of Reduced DAPT Followed by P2Y12 Inhibitor Monotherapy With Prasugrel vs stAndard Regimen in STEMI Patients

NCT05491200ST Elevated Myocardial Infarction, Dual Antiplatelet Therapy

Research Maatschap Cardiologen Rotterdam Zuid

Phase 4

1,656

Bergamo, Ferrara, Genova, Milan, Naples, Roma

2022-07-22

Active, closed

A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)

NCT05296798Locally Advanced or Metastatic Breast Cancer

DrugsGiredestrant·Phesgo·Pertuzumab·Trastuzumab

Hoffmann-La Roche

Phase 3

922

Naples, Reggio Emilia, Rimini, Rome, Brescia, Milan, Rozzano, Misterbianco (CT)

2022-07-18

Active, closed

Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma

NCT05352672Melanoma

DrugsFianlimab·Cemiplimab·Keytruda·Pembrolizumab

Regeneron Pharmaceuticals

Phase 3

1,546

Naples, San Giovanni Rotondo, Genoa, Rozzano, Candiolo, Pisa, Bari, Brescia

2022-07-14

Active, closed

A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE)

NCT05392114Hereditary Angioedema

DrugDonidalorsen

Ionis Pharmaceuticals, Inc.

Phase 3

154

Catania, Naples, Padova, Palermo, San Donato Milanese

2022-07-13

Active, closed

A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer

NCT05217446Metastatic Colorectal Cancer

DrugsEncorafenib·Erbitux·Cetuximab·Keytruda

Pfizer

Phase 2

108

Monserrato, Naples, Guastalla, San Giovanni Rotondo, Milan, Candiolo, Livorno, Pisa

2022-07-11

Recruiting

Study to Evaluate Combined Treatment of Daratumumab, Bortezomib and Dexamethasone in PBL Patients.

NCT04915248Plasmablastic Lymphoma

DrugsBortezomib·Daratumumab·Dexamethasone

Fondazione Italiana Linfomi - ETS

Phase 2

Ancona, Aviano, Florence, Miano, Monza, Naples, Roma, Palermo

2022-07-11

Recruiting

The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

NCT05203172Solid Tumors

DrugsVemurafenib·Binimetinib·Encorafenib·Zirabev

Pfizer

Phase 4

210

Bari, Perugia, Rome, Candiolo, Padova, Bologna, Milan, Naples

2022-07-05

Active, closed

Study of INCB123667 in Subjects With Advanced Solid Tumors

NCT05238922Solid Tumors

DrugsRibociclib·Palbociclib·Olaparib·Fulvestrant

Incyte Corporation

Phase 1

291

Milan, Naples, Rome, Rozzano, Verona

2022-07-05

Active, closed

Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.

NCT05267613Erosive Esophagitis

DrugNexium

AstraZeneca

Phase 3

Messina, Naples, Roma

2022-07-01

Active, closed

A Study to Evaluate Overall Health, Physical Activity, and Joint Outcomes in Participants With Severe or Moderate Hemophilia A Without Factor VIII Inhibitors on Emicizumab Prophylaxis

NCT05181618Severe Hemophilia A, Moderate Hemophilia A

DrugEmicizumab

Hoffmann-La Roche

Phase 4

136

Naples, Rome, Milan, Florence

2022-06-20

Active, closed

Non-interventional Study on Osilodrostat in Patients With Endogenous Cushing's Syndrome

NCT05382156Endogenous Cushing's Syndrome

DrugOsilodrostat

RECORDATI GROUP

Observational

206

Ancona, Milan, Naples, Roma

2022-06-13

Recruiting

A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace)

NCT05813678Phenylketonuria (PKU)

DrugPegvaliase

BioMarin Pharmaceutical

Observational

450

Bologna, Florence, Milan, Naples, Padova, Palermo, Rome

2022-06-06

Recruiting

A Multicenter Study for Evaluating a Digital Support System in Childhood Obesity Treatment

NCT04917601Childhood Obesity, Adolescent Obesity, mHealth, Personalized Medicine

Karolinska Institutet

Not applicable

680

Messina, Naples

2022-05-24

Recruiting

Selenoproteins as Prognostic Markers and Therapeutic Targets in Breast Cancer.

NCT05817227Breast Cancer

National Cancer Institute, Naples

Observational

300

Naples, Roma

2022-05-19

Active, closed

IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18)

NCT05155254Metastatic Melanoma, Unresectable Melanoma

DrugsIO102-IO103·Pembrolizumab

IO Biotech

Phase 3

407

Ancona, Aviano, Bari, Candiolo, Genova, Meldola, Milan, Naples

2022-05-17

Active, closed

A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)

NCT05374512Breast Cancer

DrugsEribulin·Dato-DXd·Nab-paclitaxel·Capecitabine

AstraZeneca

Phase 3

644

Borgo San Lorenzo, Catanzaro, Genova, Livorno, Milan, Modena, Naples, Province of Macerata

2022-05-16

Recruiting

Ruxolitinib in Primary Myelofibrosis and Secondary to Essential Thrombocythemia or Polycythemia Vera

NCT06516406Myelofibrosis, Primary Myelofibrosis, Secondary Myelofibrosis

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

1,055

Cosenza, Reggio Calabria, Naples, Bologna, Ferrara, Parma, Piacenza, Ravenna

2022-05-06

Active, closed

A Study to Evaluate the Effect of Venglustat Tablets on Left Ventricular Mass Index in Male and Female Adult Participants With Fabry Disease

NCT05280548Fabry Disease

DrugsAgalsidase beta·Replagal·Venglustat·Migalastat HCl

Sanofi

Phase 3

104

Milan, Naples, Bologna

2022-05-03

Active, closed

Adjuvant Encorafenib and Binimetinib in High-risk Stage II Melanoma With a BRAF Mutation.

NCT05270044Melanoma

Pierre Fabre Medicament

Phase 3

815

Meldola, Taormina, Naples, Aviano, Bari, Bergamo, Cuneo, Genova

2022-05-02

By invitation

AI-Enhanced Analysis of Breast Density and Background Parenchymal Enhancement (BPE)

NCT06838130Breast Parenchimal Enhancement, Artificial Intelligence (AI)

Link Campus University

Observational

213

Naples

2022-05-01

Recruiting

ADT +/- Darolutamide in de Novo Metastatic Prostate Cancer Patients With Vulnerable Functional Ability (PEACE6-Vulnerable)

NCT04916613Prostate Cancer Metastatic

DrugDarolutamide

UNICANCER

Phase 3

300

Bari, Candiolo, Foggia, Meldola, Milan, Naples, Roma, Rozzano

2022-04-19

Active, closed

Study to Evaluate the Efficacy and Safety of Venglustat in Adult and Pediatric Patients With Gaucher Disease Type 3

NCT05222906Gaucher's Disease Type III

DrugsImiglucerase·Venglustat

Sanofi

Phase 3

Milan, Naples

2022-04-18

Active, closed

Olorofim Aspergillus Infection Study

NCT05101187Invasive Aspergillosis

DrugAmbisome

F2G Biotech GmbH

Phase 3

225

Naples, Monza, Rozzano, Genova, Milan, Modena, Perugia, Pisa

2022-03-31

Recruiting

A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

NCT04928846Non Small Cell Lung Cancer, c-MET

DrugsTelisotuzumab vedotin·Docetaxel

AbbVie

Phase 3

768

Misterbianco, Milan, Naples, Rome, Bari, Cremona, Messina, Perugia

2022-03-25

Active, closed

Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)

NCT05224141Small Cell Lung Carcinoma

DrugsPembrolizumab/Vibostolimab·Tecentriq·Paraplatin·Etoposide

Merck Sharp & Dohme LLC

Phase 3

460

Naples, Milan, Rozzano, Rome

2022-03-24

Active, closed

Consolidation With Loncastuximab Tesirine After a Short Course of Immunochemotherapy in BTKi-treated (or Intolerant) Relapsed/Refractory Mantle Cell Lymphoma Patients.

NCT05249959Relapsed Mantle Cell Lymphoma, Refractory Mantle Cell Lymphoma

Fondazione Italiana Linfomi - ETS

Phase 2

Brescia, Alessandria, Cuneo, Florence, Genova, Milan, Naples, Novara

2022-03-21

Active, closed

Trial of Sibeprenlimab in the Treatment of A Nephropathy (IgAN)

NCT05248646Immunoglobulin A Nephropathy

DrugSibeprenlimab

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 3

530

Bologna, Brescia, Florence, Genova, Messina, Milan, Naples, Pavia

2022-03-15

Active, closed

A Study to Evaluate the Effect of Venglustat Tablets on Neuropathic and Abdominal Pain in Male and Female Participants ≥16 Years of Age With Fabry Disease

NCT05206773Fabry Disease

DrugVenglustat

Sanofi

Phase 3

122

Bologna, Monza, Naples, Palermo, Roma

2022-03-11

Active, closed

A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer

NCT05132582HER2 Positive Breast Cancer

DrugsPerjeta·Tucatinib·Herceptin·Pertuzumab

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

654

Naples, Genoa, Monza (MB), Catania (CT), Torrette, Trento, Livorno, Prato

2022-03-07

Active, closed

Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations

NCT05215340Metastatic Non Small Cell Lung Cancer

DrugsDato-DXd·Keytruda·Pembrolizumab

Daiichi Sankyo

Phase 3

740

Bari, Chieti, Lucca, Milan, Naples, Perugia, Rome, Varese

2022-03-04

Recruiting

Naples PCI Registry

NCT05248165Coronary Artery Disease, Percutaneous Coronary Intervention, Myocardial Ischemia, Myocardial Infarction

Federico II University

Observational

5,000

Naples

2022-03-01

Active, closed

A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

NCT05250973Amyloidosis

DrugsBortezomib·Daratumumab·Dexamethasone·Cyclophosphamide

Janssen Research & Development, LLC

Phase 2

151

Naples, Pavia, Roma

2022-03-01

Active, closed

A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour Resection

NCT05120349Non-Small Cell Lung Cancer

DrugsTagrisso·Osimertinib

AstraZeneca

Phase 3

390

Bari, Catania, Florence, Genova, Milan, Naples, Padova, Parma

2022-02-21

Recruiting

A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

NCT05128825High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

DrugAzenosertib

K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Phase 2

310

Naples, Modena, Aviano, Rome, Milan, Verona, Bologna

2022-02-17

Recruiting

Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)

NCT05263206Pruritus

DrugsFexofenadine·Dupilumab

Sanofi

Phase 3

284

Cona, Florence, Milan, Rozzano, Naples, Rome, Ancona

2022-02-15

Active, closed

A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)

NCT05031780Sickle Cell Disease

DrugMitapivat

Agios Pharmaceuticals, Inc.

Phase 2/3

286

Naples, Modena, Rome, Genoa, Palermo

2022-02-11

Recruiting

A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)

NCT04779320Crohn's Disease (CD)

DrugVedolizumab

Takeda

Phase 3

120

Naples, Bologna, Rome, Monza, Padova

2022-02-10

Active, closed

Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease

NCT05202509Atherosclerotic Cardiovascular Disease

DrugObicetrapib

NewAmsterdam Pharma

Phase 3

9,541

Ferrara, Milan, Naples, Palermo, Pavia, Rozzano, Terni

2022-02-07

Active, closed

Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)

NCT05173987Endometrial Neoplasms

DrugsTaxotere·Paraplatin·Taxol·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

280

Naples, Bologna, Meldola, Milan, Turin, Rome, Florence, Vicenza

2022-02-03

Recruiting

LOng COvid COmorbidities: Endocrine,Metabolic,Neuropsychiatric,Muscle,Cardiovascular,Pulmonary,Dermatologic Dysfunctions

NCT05293366Long Covid-19

Federico II University

Observational

100

Naples

2022-01-27

Recruiting

LOng COvid COmorbidities: Andrological, Reproductive, Sexual Dysfunctions in Patients Recovered From COVID-19

NCT05379556Long Covid-19

Federico II University

Observational

100

Naples

2022-01-27

Recruiting

MITO 35B: Olaparib Beyond Progression Compared to Platinum Chemotherapy After Secondary Cytoreductive Surgery in Recurrent Ovarian Cancer Patients.

NCT05255471Ovarian Cancer

DrugOlaparib

National Cancer Institute, Naples

Phase 3

200

Naples

2022-01-21

Recruiting

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

NCT05139017DLBCL, Diffuse Large B-Cell Lymphoma

DrugsZilovertamab vedotin·Granulocyte Colony-Stimulating Factor·Riabni·G-Csf

Merck Sharp & Dohme LLC

Phase 2/3

290

Rozzano, Bologna, Naples, Roma

2022-01-14

Active, closed

Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

NCT05407636AMD, nAMD, Wet Age-related Macular Degeneration, wAMD

DrugsEylea·Aflibercept

AbbVie

Phase 3

735

Cona, Milan, Naples, Rome, Negrar, Bari, Chieti, Udine

2022-01-13

Recruiting

International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors

NCT05363657Kidney Cancer

Azienda Ospedaliero-Universitaria Careggi

Observational

10,000

Bari, Bologna, Florence, Foggia, Genova, Messina, Milan, Naples

2022-01-10

Active, closed

Monitoring of Anti-SARS-CoV-2 (COVID 19) and Encapsulated Vaccination Patients With Thalassemic and Falcemic Syndromes

NCT05157256SARS-CoV-2 Infection, Thalasemmie, SCD

Società Italiana Talassemie ed Emoglobinopatie

Observational

1,000

Torino, Cagliari, Ferrara, Genova, Milan, Naples, Palermo, Roma

2022-01-01

Active, closed

A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)

NCT04819100Carcinoma, Non-Small-Cell Lung

DrugSelpercatinib

Eli Lilly and Company

Phase 3

152

Bari, Milan, Rozzano, Naples, Orbassano, Padova

2021-12-20

Active, closed

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT)

NCT04770753Non-Transfusion-dependent Alpha-Thalassemia, Non-Transfusion-dependent Beta-Thalassemia

DrugMitapivat

Agios Pharmaceuticals, Inc.

Phase 3

194

Brindisi, Cagliari, Ferrara, Genova, Milan, Modena, Naples, Orbassano

2021-12-20

Recruiting

A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

NCT05067283Advanced Solid Tumors

DrugsCalderasib·Leucovorin·Cetuximab·Adrucil

Merck Sharp & Dohme LLC

Phase 1

830

Rozzano, Siena, Naples

2021-12-17

Recruiting

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

NCT05176483Renal Cell Carcinoma (RCC), Metastatic Castration-Resistant Prostate Cancer (mCRPC), Urothelial Carcinoma (UC), Solid Tumor

DrugsZanzalintinib·Relatlimab·Yervoy·Ipilimumab

Exelixis

Phase 1

1,394

Ancona, Bologna, Florence, Milan, Naples, Ravenna

2021-12-14

Active, closed

Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)

NCT04954859Hepatitis B

DrugBepirovirsen

GlaxoSmithKline

Phase 2

360

Bergamo, Milan, Modena, Naples, Palermo, Pisa

2021-12-14

Recruiting

RFC1 Natural History Study

NCT05177809Ataxia

Prof. Dr. Matthis Synofzik

Observational

150

Naples, Pisa

2021-12-14

Active, closed

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2)

NCT05156281Relapsing Multiple Sclerosis

DrugsTeriflunomide·Remibrutinib

Novartis Pharmaceuticals

Phase 3

1,007

Brindisi, Foggia, Pozzilli, Messina, Modena, Pavia, Orbassano, Naples

2021-12-13

Active, closed

EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke

NCT05029414Acute Ischemic Stroke

University Hospital, Basel, Switzerland

Not applicable

543

Bologna, Florence, Naples, Torino

2021-12-09

Active, closed

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)

NCT04770779Transfusion-dependent Alpha-Thalassemia, Transfusion-dependent Beta-Thalassemia

DrugMitapivat

Agios Pharmaceuticals, Inc.

Phase 3

258

Brindisi, Cagliari, Ferrara, Genova, Milan, Modena, Naples, Orbassano

2021-11-30

Active, closed

PREvention of Intrauterine Adhesion After Adhesiolysis With Novel Tri-block deGradable Polymer Film.

NCT04963179Asherman Syndrome, Intrauterine Adhesion

Womed

Not applicable

160

Naples, Torino

2021-11-29

Active, closed

Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas

NCT04924608Neurofibromatosis 1, Plexiform Neurofibroma (PN)

DrugSelumetinib

AstraZeneca

Phase 3

145

Milan, Naples, Roma

2021-11-19

Active, closed

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS)

NCT05130450Familial Chylomicronemia Syndrome

DrugOlezarsen

Ionis Pharmaceuticals, Inc.

Phase 3

Naples, Palermo, Rome

2021-11-18

Active, closed

A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia

NCT04812925Primary Immune Thrombocytopenia

DrugEfgartigimod PH20

argenx

Phase 3

173

Ferrara, Milan, Naples

2021-11-17

Active, closed

Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia

NCT04994717Newly Diagnosed Philadelphia (Ph)-Negative B-cell Precursor Acute Lymphoblastic Leukemia (ALL)

DrugBlinatumomab

Amgen

Phase 3

303

Bari, Bergamo, Bologna, Genova, Lecce, Mestre (VE), Milan, Naples

2021-11-02

Active, closed

Savolitinib Plus Durvalumab Versus Sunitinib and Durvalumab Monotherapy in MET-Driven, Unresectable and Locally Advanced or Metastatic PRCC

NCT05043090Papillary Renal Cell Carcinoma

DrugsSavolitinib·Sunitinib·Durvalumab

AstraZeneca

Phase 3

148

Arezzo, Avellino, Bari, Bologna, Florence, Meldola, Milan, Naples

2021-10-28

Active, closed

Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer

NCT05113251Breast Neoplasms, Breast Cancer, HER2-positive Early Breast Cancer

DrugsHerzuma·Perjeta·Herceptin·Adriamycin

AstraZeneca

Phase 3

927

Bologna, Candiolo, Livorno, Milan, Naples, Negrar, Padova, Roma

2021-10-25

Recruiting

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

NCT04929223Metastatic Colorectal Cancer

DrugsDivarasib·Tiragolumab·Inavolisib·Tecentriq

Hoffmann-La Roche

Phase 1

542

Naples, Meldola, Rome, Milan, Padova

2021-10-22

Active, closed

A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)

NCT05104866Breast Cancer

DrugsEribulin·Dato-DXd·Vinorelbine·Capecitabine

AstraZeneca

Phase 3

732

Bologna, Candiolo, Florence, Meldola, Milan, Naples, Padova, Prato

2021-10-18

Active, closed

A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer

NCT04958239Neoplasms

DrugsEzabenlimab·Pembrolizumab

Boehringer Ingelheim

Phase 1

151

Naples

2021-10-18

Active, closed

Study of Vimseltinib for Tenosynovial Giant Cell Tumor

NCT05059262Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor, Diffuse

DrugVimseltinib

Deciphera Pharmaceuticals, LLC

Phase 3

123

Bologna, Milan, Naples, Padua, Rome

2021-10-14

Active, closed

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

NCT04931342Ovarian Cancer

DrugsCobimetinib·Ipatasertib·Giredestrant·Inavolisib

Hoffmann-La Roche

Phase 2

176

Bari, Naples, Rome, Milan

2021-10-07

Recruiting

PRELUDE-1 (Prospective Evaluation of Radiotherapy-induced Biologic Effects in Colorectal Cancer Oligometastatic Patients with LUng-limited Disease: Evolution of Cancer Genetics and Regulatory Immune Cells)

NCT04854213Colorectal Cancer Metastatic

National Cancer Institute, Naples

Not applicable

Naples

2021-10-06

Active, closed

Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis

NCT04926818Multiple Sclerosis (MS)

DrugsSiponimod·Fingolimod·Ofatumumab

Novartis Pharmaceuticals

Phase 3

129

Roma, Naples

2021-10-05

Active, closed

A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer

NCT04975308Breast Neoplasms, Neoplasm Metastasis

DrugsImlunestrant·Exemestane·Abemaciclib·Fulvestrant

Eli Lilly and Company

Phase 3

874

Naples, Aviano, Rome, Genoa, Florence, Padova

2021-10-04

Active, closed

A Non-interventional Cohort Safety Study of Patients With hATTR-PN

NCT04850105Hereditary Transthyretin Amyloidosis With Polyneuropthy

Akcea Therapeutics

Observational

202

Roma, Bologna, Genova, Messina, Milan, Naples, Pavia

2021-09-21

Recruiting

A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy

NCT04557462Primary IgA Nephropathy

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

540

Bologna, Naples

2021-09-20

Active, closed

A Study to Evaluate Chemotherapy Plus Osimertinib Against Chemotherapy Plus Placebo in Patients With Non-small Cell Lung Cancer (NSCLC)

NCT04765059Non-small Cell Lung Cancer

DrugCarboplatin

AstraZeneca

Phase 3

Florence, Meldola, Messina, Naples, Padova, Roma, Terni, Verona

2021-09-12

Active, closed

Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC

NCT04919811Non Small Cell Lung Cancer

DrugTaletrectinib

Nuvation Bio Inc.

Phase 2

217

Bari, Catania, Milan, Monserrato, Naples, Roma

2021-09-01

Active, closed

A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)

NCT04961996Early Breast Cancer

DrugGiredestrant

Hoffmann-La Roche

Phase 3

4,170

Avellino, Naples, Bologna, Meldola, Reggio Emilia, Roma, Milan, Rozzano (MI)

2021-08-27

Active, closed

A Study of Guselkumab and Interleukin-17 (IL-17) Inhibitor Therapies in Participants With Psoriatic Arthritis in Routine Clinical Practice

NCT05049798Arthritis, Psoriatic

DrugsIL-17i·Tremfya·Guselkumab

Janssen Pharmaceutica N.V., Belgium

Observational

1,314

Bari, Campobasso, Catanzaro, Florence, Naples, Palermo, Pisa, Potenza

2021-08-25

Active, closed

A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )

NCT04849728NASH - Nonalcoholic Steatohepatitis

Inventiva Pharma

Phase 3

1,000

San Giovanni Rotondo, Milan, Naples, Palermo, Roma, Bologna, Novara, Torino

2021-08-19

Active, closed

Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma

NCT04674683Unresectable or Metastatic Melanoma, Progressive Brain Metastasis

DrugsChidamide·Nivolumab

HUYABIO International, LLC.

Phase 3

450

Milan, Perugia, Bari, Bologna, Misterbianco, Naples, Palermo, Roma

2021-08-12

Recruiting

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

NCT04924075Pheochromocytoma/Paraganglioma, Pancreatic Neuroendocrine Tumor, Von Hippel-Lindau Disease, Advanced Gastrointestinal Stromal Tumor

DrugBelzutifan

Merck Sharp & Dohme LLC

Phase 2

355

Naples, Milan, Siena, Bologna, Brescia, Verona

2021-08-12

Active, closed

Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis

NCT04624230Ulcerative Colitis

DrugTofacitinib

Pfizer

Phase 3

118

Bergamo, Naples, Roma, Bologna

2021-08-12

Active, closed

Study to Evaluate the Pharmacokinetics, Efficacy, Tolerability, and Safety of Subcutaneous Human Immunoglobulin (Newnorm) in Patients With Primary Immunodeficiency Diseases

NCT04640142Primary Immune Deficiency

Octapharma

Phase 3

Naples, Roma, Treviso

2021-08-04

Recruiting

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

NCT04913285Solid Tumor, Adult, Non-small Cell Lung Cancer, Melanoma

Pierre Fabre Medicament

Phase 1

400

Naples

2021-08-04

Recruiting

A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

NCT04939610Solid Tumor

Drug177Lu-FAP-2286

Novartis Pharmaceuticals

Phase 1/2

222

Meldola, Milan, Naples, Reggio Emilia

2021-07-30

Active, closed

Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing

NCT04798768Tachycardia, Ventricular, Arrhythmia, Ventricular

Boston Scientific Corporation

Not applicable

297

Brescia, Cotignola, Naples, Pisa

2021-07-20

Recruiting

A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

NCT04951622Myasthenia Gravis

DrugNipocalimab

Janssen Research & Development, LLC

Phase 3

199

Catania, Cefalù, Milan, Naples, Pavia, Roma

2021-07-15

Recruiting

A Novel Vaccine (EO2463) as Monotherapy and in Combination, for Treatment of Patients With Indolent Non-Hodgkin Lymphoma

NCT04669171Follicular Lymphoma, Marginal Zone Lymphoma

DrugsLenalidomide·Rituximab

Enterome

Phase 1/2

Bologna, Naples, Pavia

2021-07-05

Active, closed

Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)

NCT04886804Neoplasm Metastasis, Non-Small Cell Lung Cancer

DrugZongertinib

Boehringer Ingelheim

Phase 1

554

Candiolo (TO), Naples, Parma

2021-07-02

Active, closed

Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)

NCT04964934ER-Positive HER2-Negative Breast Cancer

DrugsCamizestrant·Anastrozole·Abemaciclib·Ribociclib

AstraZeneca

Phase 3

315

Bergamo, Bologna, Florence, Meldola, Milan, Misterbianco, Naples, Padova

2021-06-30

Recruiting

CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

NCT05002543Cardiac Valve Disease

Corcym S.r.l

Observational

2,150

Ancona, Bologna, Brescia, Lecce, Massa, Milan, Naples, Palermo

2021-06-29

Active, closed

Global Safety and Efficacy Registration Study of Crinecerfont in Pediatric Participants With Classic Congenital Adrenal Hyperplasia (CAHtalyst Pediatric Study)

NCT04806451Congenital Adrenal Hyperplasia

DrugCrinecerfont

Neurocrine Biosciences

Phase 3

103

Bologna, Milan, Naples, Roma

2021-06-25

Active, closed

Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).

NCT04895722Colorectal Cancer

DrugsPembrolizumab/Vibostolimab·MK-4830·Pembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab

Merck Sharp & Dohme LLC

Phase 2

302

Milan, Naples, Padova

2021-06-25

Active, closed

A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy

NCT04629248Primary Membranous Nephropathy

DrugsDiphenhydramine·Acetaminophen·Tacrolimus·Methylprednisolone

Hoffmann-La Roche

Phase 3

142

Bari, Naples, Brescia, Monza, Turin

2021-06-25

Active, closed

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

NCT04793958Advanced Colorectal Cancer, Metastatic Colorectal Cancer

DrugsAdagrasib·MFOLFOX6·Erbitux·Folfox

Mirati Therapeutics Inc.

Phase 3

461

Avellino, Biella, Cagliari, Candiolo, Lido di Camaiore, Meldola, Milan, Naples

2021-06-24

Active, closed

A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer

NCT04739761Breast Cancer

DrugTrastuzumab deruxtecan

AstraZeneca

Phase 3

506

Ancona, Bergamo, Catania, Milan, Naples, Padova, Prato

2021-06-22

Recruiting

Pain ASsessment in CAncer Patients by Machine LEarning (PASCALE)

NCT04726228Oncology, Cancer Pain, Quality of Life

National Cancer Institute, Naples

Observational

Naples

2021-06-21

Active, closed

Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

NCT04895358Breast Neoplasms

DrugsLiposomal doxorubicin·Abraxane·Xeloda·Taxol

Merck Sharp & Dohme LLC

Phase 3

342

Rome, Milan, Monza, Rozzano, Bari, Catania, Naples, Padova

2021-06-18

Active, closed

A Study of Guselkumab in Participants With Active Psoriatic Arthritis

NCT04882098Arthritis, Psoriatic

DrugGuselkumab

Janssen Research & Development, LLC

Phase 3

1,054

Catania, Milan, Naples, Palermo, Rome, Torino, Verona

2021-06-17

Recruiting

A Trial Evaluating the Activity and Safety of Combination Between Cabozantinib and Temozolomide in Lung and GEP-NENS Progressive After Everolimus, Sunitinib or PRRT (CABOTEM)

NCT04893785Lung Neuroendocrine Neoplasm, GEP Neuroendocrine Tumor

National Cancer Institute, Naples

Phase 2

Naples

2021-06-15

Active, closed

Valemetostat Tosylate (DS-3201b), an Enhancer of Zeste Homolog (EZH) 1/2 Dual Inhibitor, for Relapsed/Refractory Peripheral T-Cell Lymphoma (VALENTINE-PTCL01)

NCT04703192Relapsed/Refractory Peripheral T-Cell Lymphoma, Adult T Cell Leukemia/Lymphoma

DrugValemetostat Tosylate

Daiichi Sankyo

Phase 2

155

Bergamo, Bologna, Monza, Naples, Perugia

2021-06-03

Recruiting

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

NCT04895709Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer

DrugsImzokitug·Pumitamig·Docetaxel·Nivolumab

Bristol-Myers Squibb

Phase 1/2

1,109

Rozzano, Candiolo, Milan, Naples, Roma, Siena

2021-05-27

Active, closed

Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)

NCT04704934Gastric Cancer, Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

DrugsRamucirumab·Trastuzumab deruxtecan·Paclitaxel

Daiichi Sankyo

Phase 3

490

Barone, Candiolo, Catanzaro, Milan, Modena, Naples, Padua, Pisa

2021-05-21

Recruiting

Evaluation of Main Determinants of Postprandial Glucose Response in Type 1 Diabetes

NCT05936242Type 1 Diabetes

Federico II University

Observational

200

Naples

2021-05-18

Recruiting

Longitudinal Assessment of Autonomic and Sensory Nervous System in ALS

NCT05747937Amyotrophic Lateral Sclerosis

Istituti Clinici Scientifici Maugeri SpA

Not applicable

100

Telese Terme, Naples

2021-05-15

Active, closed

The SELUTION DeNovo Study

NCT04859985Coronary Artery Disease

M.A. Med Alliance S.A.

Not applicable

3,326

Alessandria, Naples, Torino, Vercelli

2021-05-15

Active, closed

Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC

NCT04821622Prostate Cancer

DrugsTalazoparib·Enzalutamide

Pfizer

Phase 3

599

Bologna, Cremona, Meldola, San Giovanni Rotondo, Naples, Aviano, Trento, Arezzo

2021-05-12

Recruiting

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

NCT07218029Pulmonary Arterial Hypertension

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 3

815

Monza, Milan, Rome, Naples

2021-05-12

Active, closed

Prospective Observational Study of Filgotinib in Subjects With Rheumatoid Arthritis

NCT04871919Rheumatoid Arthritis

DrugFilgotinib

Alfasigma S.p.A.

Observational

1,304

Bari, Brescia, Catania, Ferrara, Genova, Milan, Naples, Roma

2021-05-11

Active, closed

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

NCT04862663Locally Advanced (Inoperable) or Metastatic Breast Cancer

DrugsCapivasertib·Abemaciclib·Ribociclib·Palbociclib

AstraZeneca

Phase 3

893

Bologna, Florence, Misterbianco, Naples, Padova, Prato, Roma

2021-05-10

By invitation

Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

NCT04848506Symptomatic Hypertrophic Cardiomyopathy (HCM)

DrugAficamten

Cytokinetics

Phase 2/3

900

Florence, Milan, Naples, Pisa, Roma, Trieste

2021-05-06

Active, closed

A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease

NCT04777331Parkinsons Disease

DrugPrasinezumab

Hoffmann-La Roche

Phase 2

586

Naples, Salerno, Bologna, Rome, Genoa, Brescia, Milan, Pozzilli (IS)

2021-05-05

Active, closed

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy

NCT04873362Breast Cancer

DrugsTrastuzumab emtansine·Herceptin·Tecentriq·Trastuzumab

Hoffmann-La Roche

Phase 3

1,188

Avellino, Naples, Modena, Aviano, Rome, Brescia, Milan, Livorno

2021-05-04

Active, closed

A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy

NCT04660344Muscle-invasive Bladder Cancer

DrugsTecentriq·Atezolizumab

Hoffmann-La Roche

Phase 3

761

Naples, Bologna, Meldola, Rome, Genoa, Milan, Orbassano, Arezzo

2021-05-03

Recruiting

Campania Registry On Peripheral Artery Disease

NCT04903912Peripheral Artery Disease

Federico II University

Observational

1,000

Naples

2021-05-01

Recruiting

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.

NCT04752774Spasticity

DrugsDysport·Corabotase

Ipsen

Phase 1/2

240

Brescia, Naples, Rome, Verona

2021-04-29

Active, closed

A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumab

NCT04770896Unresectable Hepatocellular Carcinoma

DrugsSorafenib·Tecentriq·Lenvatinib·Atezolizumab

Hoffmann-La Roche

Phase 3

557

Naples, Bologna, Rome, Milan, Turin, Palermo, Florence, Pisa

2021-04-26

Active, closed

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

NCT04784715Breast Cancer; HER2-positive; Metastatic

DrugsPertuzumab·Trastuzumab deruxtecan·Trastuzumab

AstraZeneca

Phase 3

1,157

Bergamo, Candiolo, Genova, Livorno, Milan, Naples, Padova, Rozzano

2021-04-26

Recruiting

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

NCT04752722Superficial Bladder Cancer, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ, Non-muscle Invasive Bladder Cancer

DrugPhase 2

enGene, Inc.

Phase 1/2

350

Milan, Naples, Rome, Torino

2021-04-22

Active, closed

A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.

NCT04680052Follicular Lymphoma, Marginal Zone Lymphoma

DrugsTafasitamab·Lenalidomide·Rituximab

Incyte Corporation

Phase 3

654

Bari, Brescia, Candiolo, Catania, Lecce, Milan, Naples, Novara

2021-04-15

Active, closed

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

NCT04736706Carcinoma, Renal Cell

DrugsPembrolizumab/Quavonlimab·Belzutifan·Lenvatinib·Keytruda

Merck Sharp & Dohme LLC

Phase 3

1,688

Modena, Rome, Bari, Milan, Naples, Terni

2021-04-14

Active, closed

A Study of Ixekizumab (LY2439821) in Children With Juvenile Idiopathic Arthritis Categories of Enthesitis-related Arthritis (Including Juvenile Onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis

NCT04527380Juvenile Psoriatic Arthritis, Enthesitis Related Arthritis

DrugsIxekizumab·Adalimumab

Eli Lilly and Company

Phase 3

101

Naples, Genoa, Milan, Florence, Brescia

2021-04-13

Recruiting

Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

NCT04617522Advanced or Metastatic Solid Tumor, Liver Failure

DrugSacituzumab Govitecan

Gilead Sciences

Phase 1

Milan, Naples

2021-04-06

Recruiting

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

NCT04728893Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia

DrugNemtabrutinib

Merck Sharp & Dohme LLC

Phase 2

490

Bari, Bologna, Brescia, Milan, Naples, Pavia, Reggio Emilia, Roma

2021-04-05

Active, closed

Clinical Assessment of Pharmacokinetics, Efficacy, and Safety of 10% IVIg in Pediatric PID Patients (KIDCARES10)

NCT04944979Primary Immunodeficiency Disease

DrugKedrion IVIG

Kedrion S.p.A.

Phase 3

Brescia, Florence, Genova, Milan, Naples, Roma

2021-03-31

Active, closed

Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

NCT04586023Relapsing Multiple Sclerosis

DrugsFenebrutinib·Teriflunomide

Hoffmann-La Roche

Phase 3

751

Chieti, Bari, Naples, Rome, Genoa, Milan, Montichiari, Pavia

2021-03-24

Active, closed

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

NCT04586010Relapsing Multiple Sclerosis

DrugsFenebrutinib·Teriflunomide

Hoffmann-La Roche

Phase 3

746

Foggia, Naples, Parma, Rome, Bergamo, Milan, Mondovì (CN), Catania

2021-03-17

Recruiting

Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC

NCT04686305Locally Advanced or Metastatic Non-Small Cell Lung Cancer

DrugsVolrustomig·Rilvegostomig·Trastuzumab deruxtecan·Durvalumab

AstraZeneca

Phase 1

304

Milan, Monza, Naples, Padova

2021-03-09

Recruiting

Definition of Autonomic Nervous System Involvement in Patients With Multiple Sclerosis

NCT05748015Multiple Sclerosis

Istituti Clinici Scientifici Maugeri SpA

Not applicable

Telese Terme, Naples

2021-03-04

Recruiting

Effect of Metyrapone on Cardiovascular Risk Factors in Patients With Adrenal Incidentalomas and Cushing's Syndrome

NCT06801249Adrenal Incidentalomas, Cushing Syndrome

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Phase 4

Bologna, Naples, Padova

2021-02-23

Active, closed

Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A

NCT04644575Hemophilia A

DrugEfanesoctocog alfa

Bioverativ, a Sanofi company

Phase 3

261

Naples, Milan, Vicenza

2021-02-23

Recruiting

An Observational Post-marketing Study Using Commercially Approved Biosense Webster (BWI) Medical Devices for the Treatment of Participants With Cardiac Arrhythmias

NCT04750798Arrhythmias, Cardiac

Biosense Webster, Inc.

Observational

8,000

Acquaviva delle Fonti, Ancona, Milan, Naples

2021-02-22

Active, closed

Neoadjuvant Plus Adjuvant Treatment With Cemiplimab in Cutaneaous Squamous Cell Carcinoma

NCT04632433Cutaneous Squamous Cell Carcinoma

DrugCemiplimab

Fondazione Melanoma Onlus

Phase 2

Bergamo, Bagno a Ripoli, Meldola, Milan, Naples, Padova, Brescia

2021-02-10

Recruiting

Metabolic Exercise Test Data Combined with Cardiac and Kidney Indexes (MECKI) Score Evolution: Identification of Cardiovascular Risk in Patients with Heart Failure

NCT06884631Heart Failure

Centro Cardiologico Monzino

Observational

10,000

Milan, Ancona, Bari, Bergamo, Brescia, Foggia, Naples, Palermo

2021-02-10

Active, closed

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Emicizumab in Participants From Birth to 12 Months of Age With Hemophilia A Without Inhibitors

NCT04431726Severe Hemophilia A

DrugEmicizumab

Hoffmann-La Roche

Phase 3

Naples, Parma, Milan, Florence

2021-02-04

Active, closed

A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease

NCT04711252ER-Positive HER2-Negative Breast Cancer

DrugsCamizestrant·Anastrozole·Palbociclib

AstraZeneca

Phase 3

1,371

Bergamo, Florence, Milan, Modena, Naples, Novara, Padova, Parma

2021-01-28

Active, closed

"Principle Test" for Isolation and Characterization of Circulating Cancer Cells (CTC)-CXCR4+.

NCT05818865Neoplasm Malignant

National Cancer Institute, Naples

Not applicable

Naples

2021-01-18

Active, closed

A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)

NCT04204616Prurigo Nodularis

DrugNemolizumab

Galderma R&D

Phase 3

500

Catania, Chieti, Genova, L’Aquila, Modena, Naples, Parma, Perugia

2021-01-11

Active, closed

Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)

NCT04634877Endometrial Neoplasms

DrugsDocetaxel·Keytruda·Paclitaxel·Cisplatin

Merck Sharp & Dohme LLC

Phase 3

990

Roma, Rome, Milan, Candiolo, Brescia, Naples, Padova

2021-01-10

Active, closed

A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL

NCT04521231B Cell Precursor Acute Lymphoblastic Leukemia

DrugBlinatumomab

Amgen

Phase 1/2

181

Bergamo, Bologna, Brescia, Catania, Milan, Naples, Roma

2021-01-04

Active, closed

A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations

NCT04639219Advanced Solid Tumors With HER2 Mutation,eg:Colorectal,Urothelial,Gastric, Hepatobiliary,Endometrial,Melanoma,Ovarian,Cervical,Salivary Gland,Pancreatic,Breast

DrugTrastuzumab deruxtecan

AstraZeneca

Phase 2

102

Milan, Naples

2020-12-30

Active, closed

A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer

NCT04538742Metastatic Breast Cancer

DrugsTucatinib·Pertuzumab·Trastuzumab deruxtecan·Durvalumab

AstraZeneca

Phase 1/2

245

Bologna, Milan, Naples, Rome

2020-12-28

Active, closed

A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer

NCT04607421Neoplasms

DrugsEncorafenib·Zirabev·Erbitux·Xeloda

Pfizer

Phase 3

841

Monserrato (CA), San Giovanni Rotondo, Milan, Candiolo, Orbassano, Brescia, Naples, Padova

2020-12-21

Active, closed

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

NCT04663308Primary Sclerosing Cholangitis

DrugVolixibat

Mirum Pharmaceuticals, Inc.

Phase 2

182

Bologna, Milan, Monza, Naples, Padova

2020-12-18

Active, closed

Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia

NCT04490915Congenital Adrenal Hyperplasia

DrugCrinecerfont

Neurocrine Biosciences

Phase 3

182

Ancona, Bologna, Florence, Messina, Milan, Naples, Padova, Roma

2020-12-16

Active, closed

Atrasentan in Patients With IgA Nephropathy

NCT04573478IgA Nephropathy, Immunoglobulin A Nephropathy

DrugsAtrasentan·Zigakibart

Novartis Pharmaceuticals

Phase 3

404

Milan, Genova, Naples, Pavia

2020-12-11

Active, closed

Efficacy Comparison of Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants With Advanced Non-small Cell Lung Cancer Who Have Progressed on Prior Anti-PD-(L)1 Therapy and Chemotherapy

NCT04655976Lung Cancer, Non-Small Cell

DrugsCobolimab·Dostarlimab·Docetaxel

GlaxoSmithKline

Phase 2/3

758

Ancona, Avellino, Florence, Milan, Monza, Naples, Orbassano to, Perugia

2020-12-08

Active, closed

Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene

NCT04794101X-Linked Retinitis Pigmentosa

MeiraGTx Ocular UK Ltd

Phase 3

Florence, Milan, Naples, Rome

2020-12-04

Active, closed

Assessment of the Axone Micro Quadripolar Lead for Enhanced Cardiac Resynchronization Therapy

NCT04463641Heart Failure, Cardiac Resynchronization Therapy

MicroPort CRM

Not applicable

Brescia, Naples

2020-12-03

Active, closed

Combination or Sequence of Vemurafenib, Cobimetinib, and Atezolizumab in High-risk, Resectable Melanoma

NCT04722575Melanoma

DrugsCobimetinib·Vemurafenib·Tecentriq·Atezolizumab

Fondazione Melanoma Onlus

Phase 2

Bagno a Ripoli, Meldola, Milan, Naples, Padova, Genova

2020-12-03

Active, closed

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)

NCT04548999Multiple Sclerosis

DrugsOcrelizumab·Methylprednisolone

Hoffmann-La Roche

Phase 3

769

Naples, Rome, Gallarate, Milan, Pavia, Turin

2020-12-03

Active, closed

Decoding Personalized Nutritional, Microbiome and Host Patterns Impacting Clinical and Prognostic Features in Crohn's Disease

NCT04283864Crohn Disease

Weizmann Institute of Science

Observational

267

Naples

2020-11-29

Active, closed

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)

NCT04544436Multiple Sclerosis

DrugsOcrelizumab·Methylprednisolone

Hoffmann-La Roche

Phase 3

864

Chieti, Naples, Rome, Milan, Pozzilli

2020-11-26

Recruiting

ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

NCT04561518Transthyretin-Mediated Amyloidosis, ATTR Amyloidosis

Alnylam Pharmaceuticals

Observational

1,500

Milan, Naples, Palermo, Roma

2020-11-23

Active, closed

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

NCT04644068Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer

DrugsSaruparib·Camizestrant·Dato-DXd·Trastuzumab deruxtecan

AstraZeneca

Phase 1/2

702

Milan, Modena, Naples, Padova, Roma

2020-11-12

Active, closed

Study of Efficacy and Safety of LXH254 Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma

NCT04417621Melanoma

DrugsNaporafenib·Trametinib·Ribociclib

Novartis Pharmaceuticals

Phase 2

134

Milan, Naples

2020-10-30

Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NCT04585750Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor

DrugsRezatapopt·Keytruda·Pembrolizumab

PMV Pharmaceuticals, Inc

Phase 1/2

300

Rome, Milan, Rozzano, Candiolo, Naples

2020-10-29

Active, closed

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis

NCT04544449Multiple Sclerosis, Primary Progressive

DrugsFenebrutinib·Ocrelizumab

Hoffmann-La Roche

Phase 3

985

Naples, Parma, Rome, Genoa, Milan, Montichiari, Pozzilli, Palermo

2020-10-26

Active, closed

Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer

NCT04464226Cancer

DrugDarolutamide

Bayer

Phase 3

402

Naples, Parma, Orbassano, Turin, Padova

2020-10-20

Active, closed

Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer

NCT04590963Squamous Cell Carcinoma of the Head and Neck

DrugsMonalizumab·Erbitux·Cetuximab

AstraZeneca

Phase 3

370

Brescia, Candiolo, Florence, Milan, Modena, Naples, Padova

2020-10-02

Active, closed

A Gene Transfer Study for Late-Onset Pompe Disease (RESOLUTE)

NCT04093349Pompe Disease, Pompe Disease (Late-onset), Glycogen Storage Disease Type 2, Glycogen Storage Disease Type II

Spark Therapeutics, Inc.

Phase 1/2

Messina, Milan, Naples, Pisa, Torino

2020-10-01

Active, closed

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT04487080Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab·Osimertinib

Janssen Research & Development, LLC

Phase 3

1,074

Avellino, Catania, Meldola, Milan, Monza, Naples, Orbassano, Ravenna

2020-09-30

Active, closed

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC)

NCT04497844Prostatic Neoplasms

DrugsAbiraterone acetate·Prednisone

Janssen Research & Development, LLC

Phase 3

696

Arezzo, Candiolo, Cremona, Lecce, Meldola, Milan, Naples, Orbassano

2020-09-23

Active, closed

Datopotamab Deruxtecan (Dato-DXd) in Combination With Pembrolizumab With or Without Platinum Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung02)

NCT04526691Advanced or Metastatic NSCLC

DrugsDato-DXd·Keytruda·Cisplatin·Carboplatin

Daiichi Sankyo

Phase 1

145

Milan, Monza, Naples

2020-09-15

Active, closed

Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome

NCT04401748Myelodysplastic Syndrome (MDS)

DrugsVenclexta·Azacitidine·Venetoclax

AbbVie

Phase 3

531

Rozzano, Naples, Rome, Bologna, Reggio Calabria

2020-09-10

Active, closed

A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

NCT04442022Relapsed/Refractory Diffuse Large B-cell Lymphoma

DrugsSelinexor·Rituximab·Dexamethasone·Gemcitabine

Karyopharm Therapeutics Inc

Phase 2/3

501

Ancona, Caserta, Naples, Novara, Pescara, Rome, Palermo, Turin

2020-09-03

Active, closed

Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis

NCT04468984Myelofibrosis (MF)

DrugsNavitoclax·Ruxolitinib

AbbVie

Phase 3

330

Bologna, Florence, Rome, Monza, Naples, Turin, Ancona, Bergamo

2020-08-31

Recruiting

BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours

NCT04421820Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma

DrugsFolfox·Oxaliplatin

Bold Therapeutics, Inc.

Phase 1/2

220

Milan, Naples, Pisa

2020-08-28

Active, closed

An Observational Real-world Study Evaluating Severe Tricuspid Regurgitation Patients Treated With the Abbott TriClip™ Device (bRIGHT)

NCT04483089Tricuspid Valve Regurgitation

Abbott Medical Devices

Observational

511

Cotignola, Naples

2020-08-27

Active, closed

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)

NCT04504825AL Amyloidosis

DrugsAnselamimab·Cyclophosphamide, bortezomib, and Dexamethasone (CyBorD)

Alexion Pharmaceuticals, Inc.

Phase 3

125

Naples, Pavia, Pisa, Roma

2020-08-25

Recruiting

A Randomized, Multicenter, Phase III Trial Comparing Treatment With R-mini-CHOP With R-mini-CHP + Polatuzumab Vedotin in Patients With Diffuse Large Cell B Cell Lymphoma

NCT04332822DLBCL, Diffuse Large B Cell Lymphoma

DrugR-mini-CHOP

Nordic Lymphoma Group

Phase 3

300

Aviano, Bari, Calabria, Monza, Naples, Roma, Segrate, Trieste

2020-08-19

Active, closed

Study to Evaluate the Efficacy and Safety of PF-07055480 / Giroctocogene Fitelparvovec Gene Therapy in Moderately Severe to Severe Hemophilia A Adults

NCT04370054Hemophilia A

Pfizer

Phase 3

Roma, Florence, Naples

2020-08-18

Active, closed

A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors

NCT04482309Part 1: Bladder, Biliary Tract, Cervical, Endometrial, Ovarian, Pancreatic Cancer, Rare Tumors, Any Tumor Type Excluding Breast, Gastric, Colorectal Cancer, Part 2: HER2 Expressing/Amplified Solid Tumors Excluding Breast, Gastric, Colorectal Cancer

DrugTrastuzumab deruxtecan

AstraZeneca

Phase 2

477

Milan, Naples, Rome

2020-08-18

Active, closed

Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)

NCT04509700B-Cell Malignancies

DrugsItacitinib·Parsaclisib·Ibrutinib·Ruxolitinib

Incyte Corporation

Phase 2

112

Bologna, Florence, Meldola (FC), Milan, Naples, Novara, Palermo, Pisa

2020-08-03

Recruiting

Recurrent Ovarian CarcinoSarcoma Anti-pd-1 Niraparib

NCT03651206Ovarian Carcinosarcoma, Endometrial Carcinosarcoma

DrugNiraparib

ARCAGY/ GINECO GROUP

Phase 2/3

138

Bologna, Catania, Meldola, Milan, Naples, Roma, Torino

2020-07-15

Active, closed

A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)

NCT04245839Lymphoma, Non-Hodgkin

DrugsBreyanzi·Fludarabine·Cyclophosphamide

Celgene

Phase 2

276

Bergamo, Naples

2020-07-14

Active, closed

Linerixibat Long-term Safety, and Tolerability Study

NCT04167358Cholestasis

GlaxoSmithKline

Phase 3

242

Milan, Modena, Monza, Naples, Negrar Verona, Padova, Palermo, Roma

2020-07-14

Active, closed

Phase III Study of Toripalimab（JS001） Combined With Lenvatinib for Advanced HCC

NCT04523493Advanced Hepatocellular Carcinoma (HCC)

Shanghai Junshi Bioscience Co., Ltd.

Phase 3

530

Milan, Naples, Pisa, Tortona, Verona

2020-06-29

Active, closed

A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.

NCT04224493Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma

DrugTazemetostat

Epizyme, Inc.

Phase 3

599

Naples, Meldola, Brescia, Catania, Florence, Lecce, Milan, Monza

2020-06-11

Active, closed

Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)

NCT04379596Gastric Cancer

DrugsVolrustomig·Rilvegostomig·Trastuzumab deruxtecan·Fluorouracil

AstraZeneca

Phase 2

452

Milan, Naples, Padova, Roma, Verona

2020-06-03

Active, closed

"Sleep Patterns and EEG Structure in Youth With Autism: Links With Behavior and Parental Stress"

NCT07122388Sleep Disorder (Disorder), Autism Spectrum Disorder

University of Campania Luigi Vanvitelli

Observational

187

Naples

2020-06-01

Active, closed

Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)

NCT04241185Urinary Bladder Neoplasms

DrugsMitomycin C·Fluorouracil·Adrucil·Keytruda

Merck Sharp & Dohme LLC

Phase 3

520

Bari, Rome, Milan, Florence, Modena, Naples, Province of Macerata

2020-05-19

Recruiting

EORTC Metastatic Breast Cancer Module Development

NCT07806266Metastatic Beast Cancer

University of Leeds

Observational

568

Naples, Padova

2020-05-01

Active, closed

A Study to Investigate Efficacy and Safety With Oral AZD9833 Compared With Intramuscular Fulvestrant in Post-menopausal Women at Least 18 Years of Age With Advanced ER-positive HER2 Negative Breast Cancer

NCT04214288Advanced ER-Positive HER2-Negative Breast Cancer

DrugsCamizestrant·Fulvestrant

AstraZeneca

Phase 2

240

Bologna, Catanzaro, Meldola, Messina, Milan, Monza, Naples, Roma

2020-04-22

Active, closed

Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer

NCT04305496Locally Advanced (Inoperable) or Metastatic Breast Cancer

DrugsCapivasertib·Fulvestrant

AstraZeneca

Phase 3

818

Bergamo, Candiolo, Catanzaro, Livorno, Meldola, Milan, Modena, Naples

2020-04-16

Recruiting

Covid-19 in Hematological Malignancies

NCT04733729COVID-19 Infection in Hematological Malignancies Patients

Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne

Observational

3,000

Brescia, Naples, Rome, Varese, Verona

2020-03-01

Active, closed

Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors

NCT04262466Select Advanced Solid Tumors

DrugBrenetafusp

Immunocore Ltd

Phase 1/2

410

Rome, Seriate, Naples

2020-02-25

Active, closed

A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

NCT04194944Non-Small Cell Lung Cancer

DrugsSelpercatinib·Pemetrexed·Cisplatin·Carboplatin

Eli Lilly and Company

Phase 3

261

Naples, Ravenna, Aviano, Rome, Monza, Milan, Rozzano, Orbassano

2020-02-17

Active, closed

A Study of Baricitinib (LY3009104) in Participants From 1 Year to Less Than 18 Years Old With Systemic Juvenile Idiopathic Arthritis (sJIA)

NCT04088396Systemic Juvenile Idiopathic Arthritis

DrugsBaricitinib·Tocilizumab

Eli Lilly and Company

Phase 3

Brescia, Chieti, Genova, Milan, Naples, Palermo, Trieste

2020-02-12

Active, closed

A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

NCT04211337Medullary Thyroid Cancer

DrugsVandetanib·Selpercatinib·Cabozantinib

Loxo Oncology, Inc.

Phase 3

291

Naples, Rome, Milan, Turin, Pisa, Siena, Padova, Catania

2020-02-11

Recruiting

Peripheral Extreme Revascularization in "No-option" Patiens With Chronic Limb Threatening Ischemia

NCT06277362Peripheral Arterial Disease, Critical Limb-Threatening Ischemia, Diabetic Foot

EndoCore Lab s.r.l.

Observational

Ancona, Belluno, Cesena, Conegliano, Naples, Reggio Emilia, Trento, Perugia

2020-01-31

Recruiting

Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors

NCT03934372Acute Myeloid Leukemia, Accelerated Phase Chronic Myeloid Leukemia, Blast Phase Chronic Myeloid Leukemia, Chronic Phase Chronic Myeloid Leukemia

DrugPonatinib

Incyte Biosciences International Sàrl

Phase 1/2

Bologna, Brescia, Genova, Milan, Monza, Naples, Pavia, Rome

2020-01-29

Active, closed

TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations

NCT04129502Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

DrugsMobocertinib·Pemetrexed·Cisplatin·Carboplatin

Takeda

Phase 3

354

Naples, Meldola, Milan, Orbassano, Aviano, Pisa, Parma, Ravenna

2020-01-10

Active, closed

Study to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET

NCT03972488Gastro-enteropancreatic Neuroendocrine Tumor

DrugsOctreotide LAR·Lutathera

Advanced Accelerator Applications

Phase 3

226

Bologna, Genova, Meldola, Milan, Naples, Reggio Emilia, Roma

2020-01-08

Active, closed

Pentaglobin in CRE and PA Neutropenic Infections

NCT03494959Septic Shock

Gruppo Italiano Trapianto di Midollo Osseo

Phase 2

120

Cagliari, Naples, Ancona, Bari, Bologna, Brescia, Cuneo, Florence

2019-12-06

Recruiting

Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)

NCT04202341Generalized Myasthenia Gravis

Alexion Pharmaceuticals, Inc.

Observational

500

Milan, Naples

2019-12-02

Recruiting

Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants With Beta (β)-Thalassemia

NCT04143724Beta-Thalassemia

DrugLuspatercept

Celgene

Phase 2

Rome, Genoa, Naples, Orbassano

2019-11-07

Active, closed

Rollover Study for Continued Safety and Tolerability in Subjects Treated With Spartalizumab Alone or in Combination With Other Study Treatments

NCT04058756Advanced Solid Tumors

DrugSpartalizumab

Novartis Pharmaceuticals

Phase 1

120

Milan, Rozzano, Modena, Aviano, Siena, Naples

2019-10-30

Active, closed

Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.

NCT04157348Eosinophilic Granulomatous Vasculitis

DrugsBenralizumab·Mepolizumab

AstraZeneca

Phase 3

140

Cuneo, Florence, Milan, Naples, Roma, Torino

2019-10-29

Active, closed

Effectiveness Study of Nivolumab Compared to Placebo in Prevention of Recurrent Melanoma After Complete Resection of Stage IIB/C Melanoma

NCT04099251Melanoma

DrugsOpdivo·Nivolumab

Bristol-Myers Squibb

Phase 3

790

Palermo, Bergamo, Milan, Naples, Padova, Perugia, Siena

2019-10-28

Active, closed

A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis

NCT03958877Multiple Sclerosis, Relapsing-Remitting

DrugsPlegridy·Avonex

Biogen

Phase 3

152

Florence, Naples

2019-10-18

Recruiting

Study on Gynecological Rare Cancers

NCT05733806Gynecologic Cancer

National Cancer Institute, Naples

Observational

500

Milan, Naples

2019-10-14

Active, closed

Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations

NCT04006210Parkinson's Disease

NeuroDerm Ltd.

Phase 3

381

Arcugnano, Cassino, Chieti, Grosseto, Milan, Naples, Pavia, Roma

2019-09-30

Recruiting

Study of Folfiri/Cetuximab in FcGammaRIIIa V/V Stage IV Colorectal Cancer Patients

NCT03874026Colorectal Cancer, ADCC

National Cancer Institute, Naples

Phase 2

Naples

2019-09-05

Active, closed

A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer

NCT04077463Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab·Pemetrexed·Carboplatin

Janssen Research & Development, LLC

Phase 1

701

Milan, Monza, Naples, Ravenna

2019-09-04

Recruiting

InheriteD brEast caNcer iTalian regIsTrY A Retrospective-prospective Observational Cohort Study to Evaluate Cancer Prevention Strategies in Women With a Deleterious Mutation in BRCA1-2

NCT05835739Breast Cancer

Centro di Riferimento Oncologico - Aviano

Observational

Aviano, Genova, Messina, Milan, Modena, Naples, Reggio Emilia, Roma

2019-08-27

Active, closed

Observational Evaluation of Atopic Dermatitis in Pediatric Patients

NCT03687359Dermatitis Atopic

Sanofi

Observational

1,860

Terracina, Naples, Padua, Bari, Bologna, Brescia, Catania, Milan

2019-08-15

Active, closed

A Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa in Combination With Obinutuzumab and in Combination With Glofitamab Following a Pre-Treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma

NCT04077723Lymphoma, Non-Hodgkin

DrugsGlofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 1/2

498

Naples, Bergamo, Milan, Rozzano

2019-08-13

Active, closed

A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis

NCT04035005Multiple Sclerosis, Primary Progressive

DrugOcrelizumab

Hoffmann-La Roche

Phase 3

1,013

Naples, Rome, Genoa, Milan, Pavia, Orbassano, Cefalù

2019-08-12

Active, closed

A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)

NCT04008030Metastatic Colorectal Cancer

DrugsFluorouracil·Leucovorin·Ipilimumab·Cetuximab

Bristol-Myers Squibb

Phase 3

839

Catania, Genova, Milan, Naples, Padova, Roma

2019-08-05

Active, closed

A Study of Cusatuzumab Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia Who Are Not Candidates for Intensive Chemotherapy

NCT04023526Leukemia, Myeloid, Acute

DrugsCusatuzumab·Azacitidine

OncoVerity, Inc.

Phase 2

103

Bologna, Brescia, Meldola, Milan, Naples, Udine

2019-07-29

Active, closed

A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B

NCT03861273Hemophilia B

Pfizer

Phase 3

Florence, Naples

2019-07-29

Active, closed

Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients

NCT03814746Sickle Cell Disease (SCD)

DrugCrizanlizumab

Novartis Pharmaceuticals

Phase 3

254

Genova, Milan, Verona, Naples

2019-07-26

Active, closed

Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303)

NCT03924895Urinary Bladder Cancer, Muscle-invasive

DrugsEnfortumab Vedotin·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

595

Roma, Orbassano, Vicenza, Arezzo, Catania, Milan, Naples, Pavia

2019-07-24

Active, closed

A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer

NCT03981796Neoplasms

DrugsNiraparib·Dostarlimab·Paclitaxel·Carboplatin

Tesaro, Inc.

Phase 3

785

Candiolo, Carpi MO, Lecce, Milan, Naples, Ponderano BI, Rome, Sassuolo

2019-07-18

Active, closed

Postoperative Immunotherapy vs Standard Chemotherapy for Gastric Cancer With High Risk for Recurrence

NCT03443856Gastric and Esophagogastric Junction Adenocarcinoma

DrugNivolumab and Ipilimumab

European Organisation for Research and Treatment of Cancer - EORTC

Phase 2

197

Bergamo, Milan, Naples

2019-07-17

Active, closed

Development of a Web-based Multicenter Registry on the Use of oXiris Membrane for EBPTs in Critically Ill Patients

NCT03807414Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome

Careggi Hospital

Observational

270

Esine, Empoli, San Donato Milanese, Benevento, Florence, Naples, Pavia, Perugia

2019-06-28

Active, closed

Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)

NCT03944772Non-Small Cell Lung Cancer

DrugsNecitumumab·Gefitinib·Savolitinib·Selpercatinib

AstraZeneca

Phase 2

247

Catania, Naples, Orbassano, Padova, Varese

2019-06-25

Active, closed

Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma

NCT03969004Cutaneous Squamous Cell Carcinoma

DrugCemiplimab

Regeneron Pharmaceuticals

Phase 3

415

Bergamo, Bologna, Brescia, Florence, L’Aquila, Milan, Naples, Rome

2019-06-04

Active, closed

A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL)

NCT03930953Lymphoma, Non-Hodgkin

DrugsValemetostat·Tafasitamab·Golcadomide·Obinutuzumab

Celgene

Phase 1/2

438

Bergamo, Bologna, Milan, Naples, Pavia

2019-05-20

Active, closed

Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment

NCT03847428Hepatocellular Carcinoma

DrugsAvastin·Durvalumab·Bevacizumab

AstraZeneca

Phase 3

908

Bologna, Milan, Naples, Roma, Tricase, Lecce, Verona

2019-04-29

Active, closed

Durvalumab or Placebo in Combination With Gemcitabine/Cisplatin in Patients With 1st Line Advanced Biliary Tract Cancer (TOPAZ-1)

NCT03875235Biliary Tract Neoplasms

DrugDurvalumab

AstraZeneca

Phase 3

810

Faenza, Florence, Milan, Naples, Roma, Verona

2019-04-16

Recruiting

A Study of Baricitinib in Participants From 1 Year to Less Than 18 Years Old With Juvenile Idiopathic Arthritis

NCT03773965Juvenile Idiopathic Arthritis

DrugBaricitinib

Eli Lilly and Company

Phase 3

190

Brescia, Chieti, Genova, Milan, Naples, Palermo, Trieste

2019-04-05

Active, closed

A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)

NCT03913143Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Vision Disorders

DrugSepofarsen

ProQR Therapeutics

Phase 2/3

Naples

2019-04-04

Active, closed

A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease

NCT03887455Early Alzheimer's Disease

DrugLecanemab

Eisai Inc.

Phase 3

1,906

Tricase, Cefalù, Genova, Milan, Monza, Naples, Perugia, Pisa

2019-03-27

Active, closed

Avelumab Program Rollover Study

NCT03815643Solid Tumors

DrugAvelumab

EMD Serono Research & Development Institute, Inc.

Phase 3

205

Naples, Padova, Roma, Rozzano

2019-03-22

Active, closed

Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy.

NCT03869892Metastatic Colorectal Cancer

DrugsTrifluridine/Tipiracil·Capecitabine

Institut de Recherches Internationales Servier

Phase 3

856

Cagliari, Cremona, Naples, Padova, Pisa, Potenza, Reggio Emilia, Roma

2019-03-21

Active, closed

A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors

NCT03845166Neoplasm Malignant, Renal Cell Carcinoma, Hormone Receptor Positive Breast Carcinoma, Metastatic Castration-resistant Prostate Cancer

DrugsZanzalintinib·Avelumab·Tecentriq·Atezolizumab

Exelixis

Phase 1

325

Milan, Pavia, Naples

2019-03-20

Recruiting

Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator

NCT03876054Chronic Pain

Abbott Medical Devices

Observational

2,000

Naples, Pavia

2019-03-13

Active, closed

A Global Study of Midostaurin in Combination With Chemotherapy to Evaluate Safety, Efficacy and Pharmacokinetics in Newly Diagnosed Pediatric Patients With FLT3 Mutated AML

NCT03591510FLT3-mutated Acute Myeloid Leukemia

DrugsMidostaurin·Mitoxantrone·Idarubicin·Daunorubicin

Novartis Pharmaceuticals

Phase 2

Pavia, Roma, Torino, Naples

2019-03-13

Active, closed

Follow-up in Gynecological Cancer Survivors

NCT03515993Gynecologic Cancer

European Organisation for Research and Treatment of Cancer - EORTC

Observational

1,100

Monza, Naples, Torino

2019-02-21

Active, closed

NVT ALLEGRA TAVI System TF in Failing Calcified Aortic Heart Valves in a Real-world Patient Population

NCT03613246Transcatheter Aortic Valve Implantation

NVT GmbH

Observational

346

Milan, Naples

2019-02-20

Active, closed

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

NCT03748641Castration-Resistant Prostatic Cancer

DrugsAbiraterone acetate·Niraparib·Prednisone

Janssen Research & Development, LLC

Phase 3

765

Faenza, Milan, Naples, Padova, Parma, Perugia, Pisa, Roma

2019-01-25

Recruiting

Understanding the Long-Term Management of Organic Acidemia Patients With CARBAGLU®: A Mixed Methods Approach

NCT04176523Methylmalonic Acidemia, Propionic Acidemia

DrugCarglumic Acid

RECORDATI GROUP

Observational

Florence, Milan, Monza, Naples, Padova, Turin

2019-01-15

Active, closed

Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients

NCT03737643Advanced Ovarian Cancer

DrugsOlaparib·Durvalumab·Paclitaxel·Bevacizumab

AstraZeneca

Phase 3

1,407

Brescia, Lecce, Lecco, Milan, Mirano, Naples, Reggio Calabria, Reggio Emilia

2019-01-04

Active, closed

Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

NCT03742895Advanced Solid Neoplasms

DrugOlaparib

Merck Sharp & Dohme LLC

Phase 2

329

Naples, Rozzano, Siena

2018-12-12

Active, closed

Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC

NCT03732677Muscle Invasive Bladder Cancer

DrugsDurvalumab·Gemcitabine·Cisplatin

AstraZeneca

Phase 3

1,063

Bari, Bologna, Florence, Milan, Naples, Orbassano, Pozzuoli, Verona

2018-11-16

Active, closed

Study on Olaparib Plus Abiraterone as First-line Therapy in Men With Metastatic Castration-resistant Prostate Cancer

NCT03732820Metastatic Castration-resistant Prostate Cancer

DrugsZytiga·Abiraterone acetate·Olaparib

AstraZeneca

Phase 3

895

Milan, Naples, Orbassano, Pavia

2018-10-31

Active, closed

Immunotherapy With Ipilimumab and Nivolumab Preceded or Not by a Targeted Therapy With Encorafenib and Binimetinib

NCT03235245Unresectable Stage III Melanoma, Stage IV Melanoma

DrugsBinimetinib·Encorafenib·Ipilimumab·Nivolumab

European Organisation for Research and Treatment of Cancer - EORTC

Phase 2

271

Bergamo, Naples, Padova, Roma, Siena, Turin, Udine

2018-10-30

Active, closed

A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer

NCT03602859Ovarian Neoplasms, Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma

DrugsNiraparib·Dostarlimab

Tesaro, Inc.

Phase 3

1,400

Bologna, Faenza, Lugo RA, Meldola FC, Naples

2018-10-11

Active, closed

Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer

NCT03539536Non-small Cell Lung Cancer

DrugTelisotuzumab vedotin

AbbVie

Phase 2

270

Bologna, Meldola, Milan, Naples, Rome, Orbassano, Avellino, Parma

2018-10-10

Active, closed

Study of Durvalumab Given With Chemotherapy, Durvalumab in Combination With Tremelimumab Given With Chemotherapy, or Chemotherapy in Patients With Unresectable Urothelial Cancer

NCT03682068Unresectable Locally Advanced Urothelial Cancer, Metastatic Urothelial Cancer

DrugsTremelimumab·Durvalumab·Gemcitabine·Cisplatin

AstraZeneca

Phase 3

1,246

Arezzo, Milan, Naples, Orbassano, Parma, Pavia, Roma, Terni

2018-09-27

Active, closed

Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716)

NCT03553836Melanoma

DrugsKeytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

976

Meldola, Bari, Bergamo, Genova, Milan, Naples, Padova, Roma

2018-09-12

Active, closed

A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer

NCT03456076Carcinoma, Non-Small-Cell Lung

DrugsAlectinib·Vinorelbine·Pemetrexed·Gemcitabine

Hoffmann-La Roche

Phase 3

257

Naples, Rome, Milan, Orbassano, Perugia

2018-08-16

Active, closed

A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis

NCT03568318Atopic Dermatitis

DrugUpadacitinib

AbbVie

Phase 3

1,533

Rome, Rozzano, Ancona, Catania, Milan, Naples

2018-08-09

Recruiting

Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells

NCT03435796Neoplasms

Celgene

Phase 2/3

1,541

Ancona, Bologna, Milan, Monza, Naples, Roma, Rome, Rozzano (MI)

2018-07-19

Recruiting

A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)

NCT03592472Renal Cell Carcinoma

DrugsAbexinostat·Pazopanib

Xynomic Pharmaceuticals, Inc.

Phase 3

413

Candiolo, Catania, Meldola (FC), Milan, Naples, Novara, Pavia, Pisa

2018-07-17

Active, closed

A Study of Zolbetuximab (IMAB362) in Adults With Gastric Cancer

NCT03505320Pharmacokinetics of Zolbetuximab, Gastric Cancer, Gastro-esophageal Junction (GEJ) Cancer, Pharmacokinetics of Oxaliplatin

DrugsZolbetuximab·Folinic acid·Fluorouracil·Leucovorin

Astellas Pharma Global Development, Inc.

Phase 2

143

Milan, Naples, Padova, Pisa

2018-06-29

Active, closed

Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy

NCT03755791Hepatocellular Carcinoma

DrugsSorafenib·Cabozantinib·Tecentriq·Atezolizumab

Exelixis

Phase 3

837

Tricase, Rozzano, Bologna, Brescia, Milan, Naples, Novara, Roma

2018-06-10

Active, closed

A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis

NCT03523858Progressive Multiple Sclerosis (PMS)

DrugOcrelizumab

Hoffmann-La Roche

Phase 3

927

Bari, Naples, Trieste, Rome, Genoa, Milan, Pavia, Pozzilli

2018-05-28

Recruiting

Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers

NCT03564340Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer, Recurrent Primary Peritoneal Cancer, Recurrent Endometrial Cancer

DrugsUbamatamab·Sarilumab·Cemiplimab·Tocilizumab

Regeneron Pharmaceuticals

Phase 1/2

890

Rome, Milan, Naples

2018-05-21

Active, closed

A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy

NCT03522246Epithelial Ovarian Cancer, Primary Peritoneal, Fallopian Tube Cancer, Newly Diagnosed

DrugsRucaparib·Opdivo·Nivolumab

pharmaand GmbH

Phase 3

1,097

Aviano, Candiolo, Catania, Chieti, Naples, Roma, Vicenza

2018-05-14

Active, closed

An Open-Label Phase lB/II Study of Glofitamab and Atezolizumab or Polatuzumab Vedotin in Adult Patients With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma

NCT03533283Non-Hodgkins Lymphoma

DrugsPolatuzumab Vedotin·Glofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 1/2

211

Naples, Bologna, Bergamo, Milan

2018-05-08

Active, closed

Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome

NCT03604198Cushing Syndrome

DrugRelacorilant

Corcept Therapeutics

Phase 2

125

Ancona, Milan, Naples, Padova

2018-05-07

Active, closed

Extended Access of Momelotinib in Adults With Myelofibrosis

NCT03441113Neoplasms, Post-polycythemia Vera Myelofibrosis (Post-PV MF), Primary Myelofibrosis (PMF), Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)

GlaxoSmithKline

Phase 2

237

Bologna, Florence, Genova, Milan, Monza, Naples, Pesaro, Rionero in Vulture PZ

2018-05-03

Active, closed

PEACE V: Salvage Treatment of OligoRecurrent Nodal Prostate Cancer Metastases

NCT03569241Prostate Cancer, Prostate Cancer Metastatic, Metastatic Cancer, Oligometastatic Cancer

University Hospital, Ghent

Phase 2

196

Milan, Naples, Pavia, Verona

2018-04-27

By invitation

International Registry of Congenital Portosystemic Shunt (IRCPSS)

NCT06041906Congenital Portosystemic Shunt, CPSS (Congenital Portosystemic Shunt)

Prof. Valérie Mc Lin

Observational

500

Bergamo, Naples, Palermo

2018-04-26

Active, closed

A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors

NCT03530397Selected Advanced Solid Tumors

DrugsVolrustomig·Nab-paclitaxel·Pemetrexed·Paclitaxel

MedImmune LLC

Phase 1

400

Meldola, Naples, Ravenna, Roma

2018-04-24

Active, closed

Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)

NCT03425643Non-small Cell Lung Cancer

DrugsPemetrexed·Keytruda·Gemcitabine·Cisplatin

Merck Sharp & Dohme LLC

Phase 3

797

Milano, Naples, Meldola, Rozzano, Milan, Monza, Orbassano, Brescia

2018-04-24

Active, closed

Pyruvate Kinase Deficiency Global Longitudinal Registry

NCT03481738Pyruvate Kinase Deficiency

Agios Pharmaceuticals, Inc.

Observational

500

Pescara, Naples, Genoa, Milan, Roma

2018-04-23

Active, closed

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

NCT03383458Hepatocellular Carcinoma, Liver Cancer

DrugsOpdivo·Nivolumab

Bristol-Myers Squibb

Phase 3

545

Messina, Bologna, Florence, Meldola, Milan, Modena, Monserrato, Naples

2018-04-18

Active, closed

A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma

NCT03470922Melanoma

DrugsRelatlimab·Nivolumab

Bristol-Myers Squibb

Phase 2/3

714

Turin, Bergamo, Milan, Naples, Padova, Siena

2018-04-11

Active, closed

Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)

NCT03407144Hodgkin Lymphoma

DrugsPrednisone/Prednisolone·Vinblastine·Bleomycin·Dacarbazine

Merck Sharp & Dohme LLC

Phase 2

340

Roma, Aviano, Naples, Torino

2018-04-09

Recruiting

Gene Therapy for Severe Crigler Najjar Syndrome

NCT03466463Crigler-Najjar Syndrome

Genethon

Not applicable

Bergamo, Naples

2018-03-19

Active, closed

A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer

NCT03431350Prostatic Neoplasms, Castration-Resistant

DrugsCetrelimab·Abiraterone acetate·Niraparib·Prednisone

Janssen Research & Development, LLC

Phase 2

136

Florence, Lecce, Milan, Naples, Province of Macerata

2018-03-02

Active, closed

Metabolic Parameters and Quality of Life in Women on Neo-/Adjuvant Therapy for Breast Cancer

NCT07044791Breast Cancer, Breast Cancer Invasive

Federico II University

Not applicable

120

Naples

2018-02-02

Recruiting

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

NCT03142152Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases

Cardiac Dimensions, Inc.

Not applicable

300

Naples, Roma

2018-01-01

Active, closed

Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC

NCT03395197mCRPC

Pfizer

Phase 3

1,054

Bologna, Cremona, Meldola, Terni, Trento, Orbassano, Naples

2017-12-18

Active, closed

Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Children

NCT03229564Burns

DrugsDenovoSkin·Ehsg-Kf

CUTISS AG

Phase 2

Milan, Naples

2017-10-25

Active, closed

Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma

NCT03298451Hepatocellular Carcinoma

DrugsSorafenib·Tremelimumab·Durvalumab

AstraZeneca

Phase 3

1,324

Benevento, Meldola, Milan, Naples, Perugia, Pisa, Roma, Rozzano

2017-10-11

Active, closed

A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)

NCT03178552Non-Small Cell Lung Cancer

DrugsCobimetinib·Divarasib·Vemurafenib·Entrectinib

Hoffmann-La Roche

Phase 2/3

1,000

Naples, Meldola, Aviano, Rome, Bergamo, Cremona, Milan, Monza

2017-09-22

Active, closed

A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)

NCT03148418Cancer

DrugsTecentriq·Avastin·Atezolizumab·Bevacizumab

Hoffmann-La Roche

Phase 3

382

Naples, Modena, Rome, Genoa, Milan, Monza, Novara, Orbassano

2017-09-20

Active, closed

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

NCT03170960Urothelial Carcinoma, Renal Cell Carcinoma, Non-Small Cell Lung Cancer, Castration-resistant Prostate Cancer

DrugsCabozantinib·Tecentriq·Atezolizumab

Exelixis

Phase 1

914

Meldola, Rozzano, Milan, Naples, Pavia, Roma

2017-09-05

Active, closed

Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer

NCT03155997Breast Cancer

DrugAbemaciclib

Eli Lilly and Company

Phase 3

5,637

Naples, Cona, Meldola, Monza, Milan, Rozzano, Rome, Terni

2017-07-12

Active, closed

A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

NCT03165734Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis

DrugPacritinib

Swedish Orphan Biovitrum

Phase 3

407

Bari, Bologna, Brescia, Florence, Forlì, Milan, Monza, Naples

2017-06-26

Recruiting

SPECTA: Screening Cancer Patients for Efficient Clinical Trial Access

NCT02834884All Tumor Types

European Organisation for Research and Treatment of Cancer - EORTC

Observational

4,975

Alessandria, Bologna, Brescia, Cremona, Genova, Legnago, Milan, Naples

2017-05-03

Active, closed

Study of Nivolumab in Combination With Ipilimumab or Standard of Care Chemotherapy Compared to the Standard of Care Chemotherapy Alone in Treatment of Participants With Untreated Inoperable or Metastatic Urothelial Cancer

NCT03036098Urothelial Cancer

DrugsYervoy·Ipilimumab·Opdivo·Nivolumab

Bristol-Myers Squibb

Phase 3

1,314

Arezzo, Faenza, Forlì, Grosseto, Milan, Naples

2017-03-24

Active, closed

A Study of Venetoclax in Combination With Azacitidine Versus Azacitidine in Treatment Naïve Participants With Acute Myeloid Leukemia Who Are Ineligible for Standard Induction Therapy

NCT02993523Acute Myeloid Leukemia (AML)

DrugsAzacitidine·Venetoclax

AbbVie

Phase 3

443

Lecce, Rome, Ancona, Bergamo, Bologna, Genova, Milan, Naples

2017-02-02

Recruiting

Non-Immunoglobulin E-mediated Food Allergies in Children

NCT04462978Non IgE Mediated Food Allergy, Food Protein-Induced Enteropathy, Food Protein-Induced Proctocolitis, Food Protein-Induced Enterocolitis Syndrome

Federico II University

Observational

150

Naples

2017-01-01

Recruiting

Clinical and Molecular Studies in Families With Inherited Eye Disease

NCT02771236Inherited Eye Disease

National Eye Institute (NEI)

Observational

5,000

Naples

2016-10-04

Active, closed

A Study of Abemaciclib (LY2835219) Plus Tamoxifen or Abemaciclib Alone in Women With Metastatic Breast Cancer

NCT02747004Metastatic Breast Cancer

DrugsTamoxifen·Abemaciclib

Eli Lilly and Company

Phase 2

234

Roma, Negrar, Bologna, Naples

2016-09-14

Active, closed

Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)

NCT02864992Advanced (Stage IIIB/IV) Non-small Cell Lung Cancer (NSCLC) With MET Exon 14 (METex14) Skipping Alterations or MET Amplification, Lung Adenocarcinoma Stage IIIB/IV

DrugTepotinib

EMD Serono Research & Development Institute, Inc.

Phase 2

337

Genova, Milan, Naples, Padova, Roma, Rozzano

2016-09-13

Recruiting

Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment

NCT03760835Congenital Adrenal Hyperplasia

Federico II University

Phase 4

150

Naples

2016-08-11

Active, closed

A Study of Niraparib (GSK3985771) Maintenance Treatment in Participants With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy

NCT02655016Ovarian Neoplasms

DrugNiraparib

Tesaro, Inc.

Phase 3

733

Lecce, Milan, Modena, Naples

2016-07-11

Active, closed

Neoadjuvant L19IL2/L19TNF- Pivotal Study

NCT02938299Malignant Melanoma

DrugsL19IL2·Onfekafusp alfa

Philogen S.p.A.

Phase 3

214

Genova, Milan, Padova, Naples, Siena, Trieste, Turin

2016-07-01

Active, closed

Trial on Radical Upfront Surgery in Advanced Ovarian Cancer

NCT02828618Ovarian Cancer

AGO Study Group

Not applicable

797

Milan, Naples

2016-07

Active, closed

Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors

NCT02715284Neoplasms

DrugDostarlimab

Tesaro, Inc.

Phase 1

729

Milan, Modena, Naples, Roma, Verona

2016-03-07

Recruiting

Insulin Pump vs Multiple Daily Injections of Insulin and Glyco-metabolic Control in Type 1 Diabetic Patients

NCT03463564Type 1 Diabetes Mellitus

University of Campania Luigi Vanvitelli

Phase 4

150

Naples

2016-01

Active, closed

HyaloFAST Trial for Repair of Articular Cartilage in the Knee

NCT02659215Defect of Articular Cartilage

Anika Therapeutics, Inc.

Not applicable

200

Bologna, Genova, Naples

2015-12

Active, closed

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

NCT02568267Breast Cancer, Cholangiocarcinoma, Colorectal Cancer, Head and Neck Neoplasms

DrugEntrectinib

Hoffmann-La Roche

Phase 2

534

Naples, Rome, Milan, Pisa, Perugia, Padova

2015-11-19

Active, closed

Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer

NCT02516241Urothelial Cancer

DrugsTremelimumab·Durvalumab·Gemcitabine·Cisplatin

AstraZeneca

Phase 3

1,126

Arezzo, Meldola, Milan, Naples, Orbassano, Pavia, Roma, San Giovanni Rotondo

2015-11-02

Recruiting

EffecTAVI Registry

NCT05235555Aortic Stenosis, Transcatheter Aortic Valve Replacement, TAVI

Federico II University

Observational

1,000

Naples

2015-09-01

Active, closed

Ischaemic PReconditioning In Non Cardiac surgEry

NCT02427867Myocardial Ischemia, Surgery

Università Vita-Salute San Raffaele

Not applicable

1,217

Rozzano, Busto Arsizio, Asti, Florence, Genova, Milan, Naples, Pisa

2015-04

Recruiting

Monaldi Hospital Rhythm Registry

NCT05072119Pacemaker, ICD, Implanted Loop Recorder

University of Campania Luigi Vanvitelli

Observational

5,000

Naples

2015-01-07

Recruiting

CAMpania PugliA bRanch Iliaco

NCT06946381Aortoiliac Aneurysm, Iliac Aneurysm

Federico II University

Observational

200

Bari, Naples

2015-01-01

Active, closed

Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)

NCT02319837Hormone Sensitive Prostate Cancer, Prostate Cancer, Cancer of the Prostate

DrugsLupron·Eligard·Leuprorelin·Xtandi

Pfizer

Phase 3

1,068

Roma, Cremona, Faenza RA, Lugo RA, Meldola (FC), Naples, Orbassano (TO), Ravenna

2014-12-17

Active, closed

Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

NCT02227251Diffuse Large B-cell Lymphoma

DrugSelinexor

Karyopharm Therapeutics Inc

Phase 2

244

Bologna, Florence, Naples, Novara, Rome, Siena, Torino

2014-11

Recruiting

Arrhythmias Detection in a Real World Population

NCT02275637Appropriate and Inappropriate Shock Therapy With ICD, Arrhythmias Detection

Fondazione IRCCS Policlinico San Matteo di Pavia

Observational

10,000

Bergamo, Bologna, Catania, Florence, Milan, Naples, Padua, Pavia

2014-09

Active, closed

A Non-Interventional Clinical Study to Evaluate Long-Term Safety and Effectiveness of HUMIRA (Adalimumab) in Pediatric Patients With Moderately to Severely Active Crohn's Disease (CD)

NCT02130362Crohn's Disease

AbbVie

Observational

1,446

Milan, Rome, Bologna, Messina, Naples, Palermo, Parma, Pescara

2014-08-28

Recruiting

Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis

NCT03256240Crohn's Disease

Weill Medical College of Cornell University

Not applicable

600

Florence, Rozzano, Naples

2014-03-12

Recruiting

Registro Campania Salute Network on Hypertension

NCT02211365Hypertension; Heart Disease, Hypertensive

Federico II University

Observational

10,000

Naples

2014-02

Active, closed

International Bicuspid Aortic Valve Consortium (BAVCon)

NCT01980797Bicuspid Aortic Valve Disease, Thoracic Aortic Disease in Patients With a Bicuspid Aortic Valve

Boston University

Observational

6,464

San Donato Milanese, Naples, Salerno

2013-11

Active, closed

Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLC

NCT01933932Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV

DrugsPegylated G-CSF·Pegfilgrastim·Selumetinib·Docetaxel

AstraZeneca

Phase 3

510

Bari, Genova, Livorno, Milan, Naples, Orbassano, Parma, Perugia

2013-09-25

Active, closed

Olaparib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy

NCT01874353Platinum Sensitive, BRCA Mutated, Relapsed Ovarian Cancer, Following Complete or Partial Response to Platinum Based Chemotherapy

DrugOlaparib

AstraZeneca

Phase 3

327

Milan, Modena, Naples, Padova, Roma

2013-09-03

Active, closed

Olaparib Maintenance Monotherapy in Patients With BRCA Mutated Ovarian Cancer Following First Line Platinum Based Chemotherapy.

NCT01844986Newly Diagnosed, Advanced Ovarian Cancer, FIGO Stage III-IV, BRCA Mutation

DrugOlaparib

AstraZeneca

Phase 3

450

Bari, Catania, Milan, Naples, Padova, Roma

2013-08-26

Recruiting

Lysosomal Acid Lipase (LAL) Deficiency Registry

NCT01633489Lysosomal Acid Lipase Deficiency, Cholesterol Ester Storage Disease, Wolman Disease, Acid Cholesteryl Ester Hydrolase Deficiency, Type 2

Alexion Pharmaceuticals, Inc.

Observational

300

Bari, Naples, Udine, Genoa, Bergamo, Milan, Turin, Florence

2013-05-30

Active, closed

A Long-Term Registry of Humira® (Adalimumab) in Patients With Moderately to Severely Active Ulcerative Colitis (UC)

NCT01848561Ulcerative Colitis (UC)

AbbVie

Observational

8,250

Bologna, Florence, San Giovanni Rotondo, Genoa, Rozzano, Milan, Naples, Rome

2013-04-29

Recruiting

Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

NCT01949129Acute Lymphoblastic Leukaemia

DrugsGrafalon·Treosulfan·Thiotepa·Busulfan

St. Anna Kinderkrebsforschung

Phase 2/3

1,800

Bologna, Florence, Genoa, Monza, Naples, Padova, Pavia, Pisa

2013-04

Active, closed

An Observational Registry of Abatacept in Patients With Juvenile Idiopathic Arthritis

NCT01357668Juvenile Idiopathic Arthritis

Bristol-Myers Squibb

Observational

800

Florence, Genova, Naples, Padova, Trento

2013-01-30

Recruiting

Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

NCT01574053Huntington's Disease

CHDI Foundation, Inc.

Observational

35,000

Milan, Bari, Bologna, Genoa, Naples, Rome

2012-07

Active, closed

Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)

NCT01838512Multiple Myeloma

Bristol-Myers Squibb

Observational

2,555

Pesaro, Ancona, Cagliari, Florence, Lecce, Messina, Milan, Naples

2012-06-13

Recruiting

Patient Retrospective Outcomes (PRO)

NCT01550575Chronic Pain

Boston Scientific Corporation

Observational

15,000

Alessandria, Naples, Ravenna, Rionero in Vulture, Rome, Verona

2012-04-03

Active, closed

Sentinel Node Vs Observation After Axillary Ultra-souND

NCT02167490Early Stage Breast Carcinoma

European Institute of Oncology

Not applicable

1,560

Bolzano, Brescia, Cagliari, Castellanza, Como, Mantua, Milan, Naples

2012-01

Active, closed

Neural Cardiac Therapy for Heart Failure Study (NECTAR-HF)

NCT01385176Heart Failure, Congestive Heart Failure

Boston Scientific Corporation

Not applicable

118

Milan, Naples, Pavia

2011-09-21

Recruiting

Computed Tomography Coronary Angiography (CTCA) Prognostic Registry for Coronary Artery Disease

NCT01384721Coronary Artery Disease, Atherosclerosis

Azienda Ospedaliero-Universitaria di Parma

Observational

1,000

Milan, Palermo, Parma, Urbino, Bologna, Carrara, Genova, Naples

2010-09

Recruiting

Sporadic Degenerative Ataxia With Adult Onset: Natural History Study

NCT02701036Late Onset Sporadic Cerebellar Ataxia

Ataxia Study Group

Observational

300

Naples, Rome

2010-04

Active, closed

Minimal SN Tumor Burden

NCT01942603Cutaneous Melanoma

European Organisation for Research and Treatment of Cancer - EORTC

Observational

296

Milan, Naples, Padova

2009-07

Recruiting

Global Patient Registry to Monitor Long-term Safety and Effectiveness of Increlex® in Children and Adolescents With Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD).

NCT00903110IGF1 Deficiency

Esteve Pharmaceuticals, S.A.

Observational

500

Ancona, Bolzano, Brescia, Florence, Genova, Naples, Parma, Province of Macerata

2008-12-09

Active, closed

A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies

NCT00781612Neoplasm Metastasis

DrugsPerjeta·Trastuzumab emtansine·Herceptin·Tecentriq

Genentech, Inc.

Phase 2

378

Potenza, Catanzaro, Naples, Meldola, Parma, Aviano (PN), Udine, Milan

2008-10-16

Recruiting

The EUROSCA Natural History Study

NCT02440763Spinocerebellar Ataxia

Ataxia Study Group

Observational

400

Milan, Naples

2005-07

Recruiting

Computerized Registry of Patients With Venous Thromboembolism (RIETE)

NCT02832245Venous Thromboembolism

Manuel Monreal

Observational

120,000

Avezzano, Belluno, Brescia, Avellino, Naples, Marcianise, Castelfranco, Cremona

2001-03

By invitation

EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV

NCT02699736HIV, Hepatitis B, Hepatitis C, AIDS

Copenhagen University Hospital, Rigshospitalet

Observational

23,000

Bergamo, Milan, Modena, Naples, Rome

1994-01

Cite this view

Priya Life Science (2026). Clinical trial register: studies with an Italian investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 11 October 2026. https://priyalifescience.com/clinical-trials-italy/city/naples?page=2

Query this register directly

GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Italy and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,778 studies in total at the last sync on 08 Oct 2026, 03:19 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 984 of those studies with a site in Naples.

How many clinical trials are recruiting in Naples?

509 of the 984 studies on this page are recruiting new participants as of the 08 Oct 2026, 03:19 UTC sync. A further 40 have not yet opened recruitment, 418 are active but closed to new participants, and 17 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.