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Compound · clinical trials

Tofacitinib

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 14 trials in our China, USA, UK and India registers that name Tofacitinib as an intervention. Synced 24 Sep 2026
14Trials tracked
8Recruiting now
11Lead sponsors
4Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

Tofacitinib is named as a drug or biological intervention in 14 clinical trials in our China, USA, UK and India trial registers, 8 of which are recruiting. Lead sponsors include Second Affiliated Hospital, Zhejiang University, School of Medicine (3), Shanghai Zhongshan Hospital (2) and Pfizer (1). Registered phases: Phase 4, Phase 2, Phase 3, Phase EARLY_PHASE1 and Observational. Conditions studied include Ulcerative Colitis; Takayasu Arteritis; Acute Severe Ulcerative Colitis.

Tofacitinib also has an approved-drug profile on this site (FDA label data): Xeljanz (Tofacitinib) →
01

Clinical trials of Tofacitinib

14 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT06119490 Evaluation of the Efficacy and Safety of Methylprednisolone Combined With the JAK Inhibitors in the Treatment of Toxic Epidermal Necrolysis (ClinicalTrials.gov ↗)
Toxic Epidermal Necrolysis
Phase EARLY_PHASE1 Recruiting Peng Zhang China
NCT05102448 Comparison of Tofacitinib and Methotrexate in Takayasu's Arteritis (ClinicalTrials.gov ↗)
Takayasu Arteritis
Phase 4 Recruiting Shanghai Zhongshan Hospital China
NCT06095128 A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC) (ClinicalTrials.gov ↗)
Ulcerative Colitis
Phase 4 Recruiting Takeda USA
NCT06498089 A Randomized, Controlled, Open-label, Multicenter Clinical Trial Comparing the Efficacy and Safety of a Precision Treatment Regimen Based on Clinical-molecular Phenotypes with a Conventional Treatment Regimen in the Treatment of Patients with Active Takayasu's Arteritis (ClinicalTrials.gov ↗)
Takayasu Arteritis
Phase 4 Recruiting Shanghai Zhongshan Hospital China
NCT05348213 Novel Targeted Drugs Combined With R-ICE Regimen in Relapsed and Refractory Diffuse Large B-cell Lymphoma (ClinicalTrials.gov ↗)
Diffuse Large B Cell Lymphoma
Phase 2 Recruiting Ruijin Hospital China
NCT05845723 Tocilizumab and Tofacitinib in the Treatment of Vascular Behรงet's Syndrome (ClinicalTrials.gov ↗)
Aneurysm, Behcet Syndrome, Vascular Type
Phase 2 Recruiting Peking Union Medical College Hospital China
NCT07547930 Tofacitinib for Glucocorticoid-Resistant Moderate-to-Severe Thyroid Eye Disease (ClinicalTrials.gov ↗)
Thyroid Eye Disease, TED, Graves Ophthalmopathy, Graves Orbitopathy
Phase 2 Recruiting The First Affiliated Hospital of Xiamen University China
NCT06573593 Efficacy and Safety of JAK Inhibitors in Patients With AA: RWE Study (ClinicalTrials.gov ↗)
Alopecia Areata, Janus Kinase Inhibitors
Observational Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine China
NCT06689982 Tofacitinib in Patients With Amyotrophic Lateral Sclerosis (ClinicalTrials.gov ↗)
Amyotrophic Lateral Sclerosis
Phase EARLY_PHASE1 Not yet open Beijing Tiantan Hospital China
NCT07530367 Tofacitinib Plus Imatinib in Moderate-to-Severe Palmoplantar Pustulosis (ClinicalTrials.gov ↗)
Palmoplantar Pustulosis (PPP)
Phase 3 Not yet open Second Affiliated Hospital, Zhejiang University, School of Medicine China
NCT07297069 Combination Therapy With Infliximab and Tofacitinib for Acute Severe Ulcerative Colitis - CINTO Trial (ClinicalTrials.gov ↗)
Acute Severe Ulcerative Colitis
Phase 2 Not yet open Asian Institute of Gastroenterology, India India
NCT06438679 3T Therapy in the Treatment of MDA5-positive Dermatomyositis (ClinicalTrials.gov ↗)
Dermatomyositis
Phase 4 By invitation Second Affiliated Hospital, Zhejiang University, School of Medicine China
NCT04624230 Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis (ClinicalTrials.gov ↗)
Ulcerative Colitis
Phase 3 Active, closed Pfizer UK, USA
NCT06020144 A Phase 3 Study Comparing TLL-018 to Tofacitinib in RA Subjects With Inadequate Response or Intolerance to bDMARDs (ClinicalTrials.gov ↗)
Rheumatoid Arthritis
Phase 3 Active, closed Hangzhou Highlightll Pharmaceutical Co., Ltd China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

16 conditions
Condition (as registered)Trials
Ulcerative Colitis2
Takayasu Arteritis2
Acute Severe Ulcerative Colitis1
Amyotrophic Lateral Sclerosis1
Thyroid Eye Disease, TED1
Graves Ophthalmopathy1
Graves Orbitopathy1
Diffuse Large B Cell Lymphoma1
Alopecia Areata1
Janus Kinase Inhibitors1
Toxic Epidermal Necrolysis1
Rheumatoid Arthritis1
Palmoplantar Pustulosis (PPP)1
Aneurysm1
Behcet Syndrome, Vascular Type1
Dermatomyositis1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Second Affiliated Hospital, Zhejiang University, School of Medicine3
Shanghai Zhongshan Hospital2
Pfizer1
Takeda1
Asian Institute of Gastroenterology, India1
Beijing Tiantan Hospital1
The First Affiliated Hospital of Xiamen University1
Ruijin Hospital1
Peng Zhang1
Hangzhou Highlightll Pharmaceutical Co., Ltd1
Peking Union Medical College Hospital1
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Tofacitinib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Tofacitinib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.