Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas

Condition(s) studied

Investigational drug(s) / intervention(s)

Multiparameter analysis of each sample: Retrospective and prospective samples will be collected and analyzed for the study of molecular and viral biomarkers. Simultaneously, fibroblastic tumor-associated cells (CAFs) will be isolated from prospective samples. Through co-cultivation with immortalized cell lines derived from anogenital and head-neck SCCs, these CAFs will enable the production of 3D organoids for use in experiments assessing the response to telomerase and deacetylase SIRT1 inhibitors, both in vitro and in preclinical models.

Study summary

This is a multicentric, retrospective, and prospective biomarker study.

Eligibility

Primary outcome measure(s)

• Primary Endpoint — 30 months
  Identify shared molecular profiles in squamous cell carcinomas (SCC) of the mucosa of the anogenital tract and head-neck region, dependent on the presence of somatic mutations (e.g., TERT promoter mutations and viral HPV sequences).

Trial sites (4)

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