Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment
Condition(s) studied
Investigational drug(s) / intervention(s)
Durvalumab: Durvalumab IV (intravenous)
Bevacizumab: Bevacizumab IV (intravenous)
Placebo: Saline solution for Durvalumab and/or Bevacizumab masking (IV intravenous) or Dextrose for Durvalumab masking
Study summary
A global study to assess the efficacy and safety of durvalumab in combination with bevacizumab or durvalumab alone in patients with hepatocellular carcinoma who are at high risk of recurrence.
Eligibility
Primary outcome measure(s)
- Recurrence-free survival (RFS) for Arm A vs Arm C — Up to 49 months after first patient randomized
RFS (per RECIST 1.1 criteria as assessed by BICR) will be defined as the time from the date of randomization until the date of the first objective radiologic recurrence or death due to any cause, whichever occurs first.
Trial sites (217)
| Facility | City | Region | Status |
|---|---|---|---|
| Research Site | Birmingham | Alabama | |
| Research Site | Mobile | Alabama | |
| Research Site | Phoenix | Arizona | |
| Research Site | Costa Mesa | California | |
| Research Site | La Jolla | California | |
| Research Site | Long Beach | California | |
| Research Site | Orange | California | |
| Research Site | Sacramento | California | |
| Research Site | Washington D.C. | District of Columbia | |
| Research Site | Miami | Florida | |
| Research Site | Tampa | Florida | |
| Research Site | Honolulu | Hawaii | |
| Research Site | Chicago | Illinois | |
| Research Site | Westwood | Kansas | |
| Research Site | Louisville | Kentucky | |
| Research Site | Shreveport | Louisiana | |
| Research Site | Detroit | Michigan | |
| Research Site | Grand Rapids | Michigan | |
| Research Site | Rochester | Minnesota | |
| Research Site | Omaha | Nebraska | |
| Research Site | New Brunswick | New Jersey | |
| Research Site | Albuquerque | New Mexico | |
| Research Site | New York | New York | |
| Research Site | Stony Brook | New York | |
| Research Site | Durham | North Carolina | |
| Research Site | Winston-Salem | North Carolina | |
| Research Site | Cleveland | Ohio | |
| Research Site | Philadelphia | Pennsylvania | |
| Research Site | Pittsburgh | Pennsylvania | |
| Research Site | Spartanburg | South Carolina | |
| Research Site | Knoxville | Tennessee | |
| Research Site | Memphis | Tennessee | |
| Research Site | Dallas | Texas | |
| Research Site | Madison | Wisconsin | |
| Research Site | Kogarah | Australia | |
| Research Site | Melbourne | Australia | |
| Research Site | Nedlands | Australia | |
| Research Site | Westmead | Australia | |
| Research Site | Innsbruck | Austria | |
| Research Site | Linz | Austria |
+ 177 more sites — see the full list on the official registry below.
More AstraZeneca trials in Italy
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT03847428 on ClinicalTrials.gov ↗ ← All trials in Italy