Clinical Trials in Michigan, 2026, page 3 of 3

Trials with a site in Michigan

Status

Study

Lead sponsor

Phase

Enrol

US states

Start

Active, closed

DOR/ISL in HIV-1 Antiretroviral Treatment-naïve Participants (MK-8591A-053)

NCT05705349HIV-1 Infection

DrugsDOR/ISL·B/F/TAF

Merck Sharp & Dohme LLC

Phase 3

537

Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Michigan

2023-03-08

Active, closed

The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study

NCT05489588Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis

W.L.Gore & Associates

Not applicable

165

California, Connecticut, District of Columbia, Florida, Illinois, Massachusetts, Michigan, New Jersey

2023-03-02

Active, closed

A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)

NCT05738486Alzheimer's Disease, Dementia, Brain Diseases, Central Nervous System Diseases

DrugsDonanemab·Dexamethasone

Eli Lilly and Company

Phase 3

1,175

Arizona, California, Florida, Georgia, Massachusetts, Michigan, New Jersey, Rhode Island

2023-02-28

Active, closed

Study of DECOY20 With or Without Tislelizumab in Patients With Advanced Solid Tumors

NCT05651022Solid Tumor, Adult, HCC - Hepatocellular Carcinoma, CRC (Colorectal Cancer), Pancreatic Adenocarcinoma

DrugTislelizumab

Indaptus Therapeutics, Inc

Phase 1/2

120

California, Georgia, Michigan, Missouri, New Jersey, New York, Ohio, Pennsylvania

2023-02-28

Active, closed

Assessment of GORE® SYNECOR Biomaterial in Focused Patient Populations and Long-Term Application

NCT05094089Hernia, Ventral, Hernia Incisional, Hernia Incisional Ventral

W.L.Gore & Associates

Observational

320

Georgia, Massachusetts, Michigan, New Mexico, New York, North Carolina, South Carolina, Virginia

2023-02-24

Active, closed

Study With Various Immunotherapy Treatments in Participants With Lung Cancer

NCT05676931Advanced Non-Small Cell Lung Cancer

DrugsQuemliclustat·Domvanalimab·Zimberelimab·Docetaxel

Gilead Sciences

Phase 2

400

Alabama, California, Florida, Illinois, Louisiana, Michigan, Virginia, Washington

2023-02-21

Active, closed

A Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) (MK-8591A-052)

NCT05630755HIV-1 Infection

DrugsDOR/ISL·B/F/TAF

Merck Sharp & Dohme LLC

Phase 3

514

Arizona, California, District of Columbia, Florida, Georgia, Massachusetts, Michigan, Missouri

2023-02-17

Active, closed

Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD

NCT05711940Treatment Resistant Depression

DrugPsilocybin

COMPASS Pathways

Phase 3

572

Arizona, California, Florida, Georgia, Illinois, Massachusetts, Michigan, Minnesota

2023-02-14

Active, closed

(Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer

NCT05607004Breast Neoplasms, Invasive Breast Cancer, Estrogen-receptor-positive Breast Cancer, HER2-negative Breast Cancer

DrugsZoladex·Goserelin

Atossa Therapeutics, Inc.

Phase 2

Arizona, California, Florida, Illinois, Kentucky, Michigan, Minnesota, Missouri

2023-02-14

Active, closed

A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A

NCT05685238Haemophilia A, Haemophilia A With Inhibitors

Novo Nordisk A/S

Phase 3

451

California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa, Michigan

2023-02-13

Active, closed

Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)

NCT05609968Carcinoma, Non-Small-Cell Lung

DrugsSacituzumab Govitecan·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

614

Alabama, California, Florida, Georgia, Louisiana, Michigan, Minnesota, New York

2023-02-06

Recruiting

HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes

NCT07546929Type 2 Diabetes

Housey Healthcare ULC

Phase 2

300

California, Florida, Georgia, Kansas, Louisiana, Michigan, Nebraska, Nevada

2023-02-03

Active, closed

Gene Transfer Clinical Trial for Infantile and Late Infantile Krabbe Disease Treated Previously With HSCT

NCT05739643Krabbe Disease

Forge Biologics, Inc

Phase 1/2

California, Michigan, North Carolina

2023-02-03

Active, closed

A Study of Efficacy and Safety of Ianalumab Versus Placebo in Addition to Eltrombopag in Primary Immune Thrombocytopenia Patients Who Failed Steroids

NCT05653219Primary Immune Thrombocytopenia

DrugsEltrombopag·Ianalumab

Novartis Pharmaceuticals

Phase 3

152

Arizona, Colorado, Illinois, Massachusetts, Michigan, Montana, New York

2023-02-02

Recruiting

Automated Ultrasound Cardiac Guidance Tool

NCT05649826Ultrasound Imaging

UltraSight

Observational

200

Michigan

2023-02-01

Active, closed

Open-Label Extension Study of DCCR in Patients With Prader-Willi Syndrome

NCT05701774Prader-Willi Syndrome

Soleno Therapeutics, Inc.

Phase 3

California, Florida, Georgia, Indiana, Maryland, Massachusetts, Michigan, Minnesota

2023-01-31

Recruiting

A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)

NCT04782258Autosomal Recessive Polycystic Kidney (ARPKD)

DrugTolvaptan

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 3

District of Columbia, Georgia, Illinois, Indiana, Louisiana, Maryland, Michigan, Minnesota

2023-01-23

Recruiting

To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation

NCT05541822Advanced Solid Tumors

DrugLazertinib

Abion Inc

Phase 2

178

Florida, Michigan, Texas

2023-01-17

Recruiting

Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

NCT05702229Gastric Cancer

DrugsSonesitatug Vedotin·Volrustomig·Xelox·Rilvegostomig

AstraZeneca

Phase 2

163

California, Louisiana, Michigan, New York, Pennsylvania

2023-01-16

Active, closed

A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery

NCT05608291Melanoma

DrugsFianlimab·Cemiplimab·Keytruda·Pembrolizumab

Regeneron Pharmaceuticals

Phase 3

1,564

California, Colorado, Florida, Illinois, Massachusetts, Michigan, New Jersey, New York

2023-01-16

Active, closed

A Study to Evaluate Effectiveness and Safety of Deucravacitinib (BMS-986165) Compared With Placebo in Participants With Active Systemic Lupus Erythematosus

NCT05620407Systemic Lupus Erythematosus

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

513

California, Florida, Georgia, Illinois, Louisiana, Massachusetts, Michigan, Minnesota

2023-01-12

Active, closed

First in Human Study of IMGN151 in Recurrent Gynaecological Cancers

NCT05527184Endometrial Cancer, High Grade Serous Adenocarcinoma of Ovary, Primary Peritoneal Carcinoma, Fallopian Tube Cancer

DrugIMGN151

AbbVie

Phase 1

256

Alabama, California, Colorado, Florida, Illinois, Massachusetts, Michigan, Mississippi

2023-01-11

Recruiting

Phase 1/2 Study to Evaluate EP0062 as Monotherapy and in Combination in Patients With Advanced or Metastatic AR+/HER-2-/ER+ Breast Cancer

NCT05573126Hormone Receptor-positive Breast Cancer, Hormone Receptor Positive HER-2 Negative Breast Cancer, Metastatic Breast Cancer

DrugsElacestrant·Exemestane·Everolimus·Abemaciclib

Ellipses Pharma

Phase 1/2

Connecticut, Florida, Massachusetts, Michigan, Tennessee, Texas, Virginia

2023-01-11

Active, closed

Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

NCT05526560Mitral Stenosis, Mitral Valve Insufficiency

Edwards Lifesciences

Observational

504

California, Florida, Georgia, Indiana, Michigan, Minnesota, Missouri, New York

2023-01-11

Active, closed

A Phase 3 Study of Obexelimab in Patients With IgG4-Related Disease

NCT05662241IgG4 Related Disease

DrugObexelimab

Zenas BioPharma (USA), LLC

Phase 3

194

California, Florida, Georgia, Massachusetts, Michigan

2023-01-09

Recruiting

Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare

NCT05658575Acute Gout Flare, Gout Attack, Gout Flare, Gouty Arthritis

DrugDapansutrile

Olatec Therapeutics, Inc.

Phase 2/3

300

Alabama, Arizona, California, Florida, Georgia, Illinois, Kentucky, Michigan

2023-01-06

Active, closed

A Study Evaluating AB248 Alone or in Combination With Pembrolizumab in Adult Patients With Solid Tumors

NCT05653882Solid Tumor, Non Small Cell Lung Cancer, Melanoma, Squamous Cell Carcinoma of Head and Neck

DrugsEtakafusp alfa·Keytruda·Pembrolizumab

Asher Biotherapeutics, Inc.

Phase 1

552

California, Connecticut, Florida, Illinois, Massachusetts, Michigan, Missouri, New Jersey

2023-01-04

Recruiting

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

NCT05592626Advanced Solid Tumors, Genital Neoplasm, Female, Urogenital Neoplasms, Lung Neoplasm

DrugSTAR0602

Marengo Therapeutics, Inc.

Phase 1/2

366

California, Florida, Kansas, Maryland, Massachusetts, Michigan, Ohio, Tennessee

2023-01-04

By invitation

A Long-Term Follow-Up Study in Severe Hemophilia A Subjects Who Received BMN 270 in a Prior BioMarin Clinical Trial (270-401)

NCT05768386Hemophilia A

BioMarin Pharmaceutical

Observational

172

California, Colorado, Florida, Kentucky, Michigan, Missouri, Ohio, Pennsylvania

2023-01-01

Active, closed

A Study of Efficacy and Safety of Ianalumab in Previously Treated Patients With Warm Autoimmune Hemolytic Anemia

NCT05648968Warm Autoimmune Hemolytic Anemia (wAIHA)

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

Michigan, Minnesota, Washington

2022-12-30

Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment

NCT07036133Advanced Solid Tumors, Hematologic Malignancies

DrugPralatrexate

Acrotech Biopharma Inc.

Phase 1

California, Illinois, Michigan, Ohio

2022-12-28

By invitation

Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema

NCT05396105Hereditary Angioedema, Hereditary Angioedema Type I, Hereditary Angioedema Type II, Hereditary Angioedema Types I and II

DrugDeucrictibant

Pharvaris Netherlands B.V.

Phase 2/3

150

Alabama, Arkansas, California, Colorado, Maryland, Massachusetts, Michigan, Missouri

2022-12-28

By invitation

Impella ECP Study (ECP Study) and Impella ECP Continued Access Protocol

NCT05334784High-Risk Percutaneous Coronary Intervention

Abiomed Inc.

Not applicable

856

Arizona, Arkansas, California, Florida, Georgia, Louisiana, Massachusetts, Michigan

2022-12-20

Recruiting

JAB-2485 Activity in Adult Patients With Advanced Solid Tumors

NCT05490472Solid Tumors, ER+ Breast Cancer, Triple Negative Breast Cancer, TNBC, ARID1A Gene Mutation

Jacobio Pharmaceuticals Co., Ltd.

Phase 1/2

102

Michigan, Missouri, Texas, Utah

2022-12-20

Active, closed

A Study of YL202 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer and Breast Cancer

NCT05653752Non Small Cell Lung Cancer, Breast Cancer

DrugYL202

MediLink Therapeutics (Suzhou) Co., Ltd.

Phase 1

Florida, Michigan, Texas, Virginia, Washington

2022-12-20

Recruiting

A Trial of Lu AG13909 in Participants With Congenital Adrenal Hyperplasia

NCT05669950Congenital Adrenal Hyperplasia

DrugLu AG13909

H. Lundbeck A/S

Phase 1/2

Michigan

2022-12-19

Recruiting

A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

NCT05287126Ulcerative Colitis

DrugEtrasimod

Pfizer

Phase 2

Arkansas, California, Florida, Illinois, Massachusetts, Michigan, Ohio, Texas

2022-12-16

Active, closed

A Study of Daratumumab

NCT05438043Multiple Myeloma

DrugsCarfilzomib·Pomalidomide·Daratumumab·Lenalidomide

Janssen Research & Development, LLC

Phase 3

213

Florida, Georgia, Michigan, Missouri, New York, Texas

2022-12-15

Active, closed

Study of CHS-114 in Participants With Advanced Solid Tumors

NCT05635643Advanced Solid Tumor, Head and Neck Squamous Cell Carcinoma

DrugsCHS-114·Toripalimab

Coherus Oncology, Inc.

Phase 1

California, Georgia, Kentucky, Maryland, Michigan, Missouri, Ohio, Tennessee

2022-12-15

Recruiting

BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia

NCT05768932Advanced Solid Tumor, TNBC - Triple-Negative Breast Cancer, Gastric Cancer, Leukemia Acute Myeloid Leukemia (AML)

SillaJen, Inc.

Phase 1

260

Connecticut, Florida, Georgia, Michigan, New York, Oregon, Texas

2022-12-14

Active, closed

Kaneka Endovascular Embolization and Protection

NCT05563051Aneurysm Cerebral

Kaneka Medical America LLC

Not applicable

164

Michigan, New York, Ohio, Oklahoma

2022-12-13

Active, closed

Clinical Investigation of the da Vinci Surgical System

NCT05682742Thymoma, Mediastinal Tumor, Gynecologic Disease, Gynecologic Cancer

Intuitive Surgical

Not applicable

Florida, Michigan, New Jersey, Ohio

2022-12-12

Active, closed

A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7497372 in Participants With Diabetic Macular Edema (DME)

NCT06847854Diabetic Macular Edema

Genentech, Inc.

Phase 1

151

Arizona, Arkansas, California, Florida, Maryland, Michigan, Minnesota, Mississippi

2022-12-08

Recruiting

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

NCT05579366High Grade Epithelial Ovarian Cancer, High Grade Serous Ovarian Cancer, Primary Peritoneal Carcinoma, Fallopian Tube Cancer

DrugsRina-S·Bevacizumab·Carboplatin·Pembrolizumab

Genmab

Phase 1/2

884

Arizona, California, Florida, Georgia, Kansas, Maryland, Massachusetts, Michigan

2022-12-07

Active, closed

Study to Evaluate Adverse Events, Change in Disease Activity, and How ABBV-706 Moves Through the Body When Intravenously (IV) Infused Alone or in Combination With IV Infused Budigalimab, Cisplatin, or Carboplatin in Adult Participants With Advanced Solid Tumors

NCT05599984Advanced Solid Tumors

DrugsABBV-706·Budigalimab·Cisplatin·Carboplatin

AbbVie

Phase 1

288

Arizona, California, Connecticut, District of Columbia, Illinois, Indiana, Iowa, Michigan

2022-12-05

Active, closed

A Study of Botensilimab and Balstilimab for the Treatment of Colorectal Cancer

NCT05608044Metastatic Colorectal Cancer

DrugsBalstilimab·Botensilimab

Agenus Inc.

Phase 2

234

Arizona, California, Colorado, Delaware, Florida, Massachusetts, Michigan, New Jersey

2022-11-30

Active, closed

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

NCT05538130Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer

DrugPF-07799933

Pfizer

Phase 1

148

Alabama, Arkansas, California, Florida, Louisiana, Massachusetts, Michigan, New Jersey

2022-11-30

Active, closed

AB-1015, an Integrated Circuit T (ICT) Cell Therapy in Patients With Platinum Resistant Epithelial Ovarian Cancer

NCT05617755Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms

Arsenal Biosciences, Inc.

Phase 1

California, Colorado, Iowa, Michigan, New York, Texas, Washington

2022-11-29

Recruiting

A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors

NCT05584670Solid Tumor

DrugsSAR445877·ADG126·Zirabev·Erbitux

Sanofi

Phase 1/2

542

Delaware, Iowa, Kansas, Michigan, New Jersey, New York, Rhode Island, Texas

2022-11-29

Active, closed

Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation

NCT05609578Advanced NSCLC, Metastatic Lung Cancer

DrugAdagrasib

Mirati Therapeutics Inc.

Phase 2

California, Colorado, Florida, Illinois, Kansas, Massachusetts, Michigan, Minnesota

2022-11-22

Active, closed

A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products

NCT05476926Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Branch Retinal Vein Occlusion

DrugsVabysmo·Faricimab

Hoffmann-La Roche

Observational

6,000

Arizona, California, Florida, Illinois, Kentucky, Maryland, Michigan, Pennsylvania

2022-11-21

By invitation

EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study

NCT05610787Heart Failure, Transplant; Failure, Heart, Congenital Heart Disease

Berlin Heart, Inc

Not applicable

California, Colorado, District of Columbia, Florida, Illinois, Massachusetts, Michigan, Missouri

2022-11-14

Active, closed

LAMBDA 002 (Lung Registry) Study

NCT05170425Lung Transplant Rejection

Natera, Inc.

Observational

154

California, Illinois, Maryland, Michigan, Missouri, New York, Ohio, Texas

2022-11-04

Active, closed

A Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation (ALLOHA)

NCT05473910AML, MDS

DrugTSC-101

TScan Therapeutics, Inc.

Phase 1

310

California, Colorado, Connecticut, Florida, Georgia, Maryland, Massachusetts, Michigan

2022-11-01

Recruiting

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

NCT05208762Carcinoma, Non-Small-Cell Lung, Squamous Cell Carcinoma of the Head and Neck, Esophageal Squamous Cell Carcinoma, Triple Negative Breast Neoplasms

DrugsPF-08046054·Keytruda·Pembrolizumab

Seagen, a wholly owned subsidiary of Pfizer

Phase 1

714

Alabama, California, Iowa, Michigan, Ohio, Texas, Utah, Virginia

2022-10-25

Active, closed

The GORE® VIABAHN® FORTEGRA Venous Stent IVC Study

NCT05409976Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis

W.L.Gore & Associates

Not applicable

136

California, District of Columbia, Illinois, Michigan, New York, North Carolina, Virginia

2022-10-25

Active, closed

Abbott Atrial Fibrillation Post Approval Study

NCT05434650Atrial Arrhythmia, Atrium; Fibrillation, Atrial Tachycardia

Abbott Medical Devices

Observational

200

Alabama, Arkansas, California, Georgia, Louisiana, Massachusetts, Michigan, Mississippi

2022-10-21

Active, closed

A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma

NCT05259839Relapsed/Refractory Multiple Myeloma

DrugsEtentamig·Pomalidomide·Daratumumab·Lenalidomide

AbbVie

Phase 1

283

Arkansas, Florida, Maryland, Massachusetts, Michigan, New Jersey, New York, North Carolina

2022-10-20

Active, closed

Study of Oral MRT-2359 in Selected Cancer Patients

NCT05546268NSCLC, SCLC, High Grade Neuroendocrine Cancer, DLBCL

DrugMRT-2359

Monte Rosa Therapeutics, Inc

Phase 1/2

174

Arizona, California, Connecticut, Kansas, Massachusetts, Michigan, Missouri, New York

2022-10-12

Active, closed

Study of RYZ101 in Combination With SoC in Subjects With SSTR+ ES-SCLC

NCT05595460SCLC,Extensive Stage

DrugsRYZ101·Etoposide·Atezolizumab·Carboplatin

RayzeBio, Inc.

Phase 1

California, Florida, Iowa, Kentucky, Michigan, Minnesota, Missouri, Nebraska

2022-10-10

Recruiting

A Study of EP0031 (Lunbotinib) in Patients With Advanced RET-altered Malignancies

NCT05443126NSCLC

DrugPemetrexed

Ellipses Pharma

Phase 1/2

265

California, District of Columbia, Florida, Illinois, Kentucky, Massachusetts, Michigan, New York

2022-09-30

Active, closed

A Retrospective Assessment of OviTex PRS (OviTex)

NCT05736848Reconstructive Surgical Procedures

Tela Bio Inc

Observational

200

Florida, Georgia, Massachusetts, Michigan, New Jersey, New York, South Carolina, Texas

2022-09-27

Recruiting

Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT05327114Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

DrugNipocalimab

Janssen Research & Development, LLC

Phase 2/3

201

Colorado, Florida, Georgia, Kansas, Maryland, Massachusetts, Michigan, Missouri

2022-09-23

Recruiting

A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD

NCT05431088Sickle Cell Disease

Pfizer

Phase 2/3

389

Alabama, Connecticut, Florida, Georgia, Illinois, Louisiana, Michigan, Mississippi

2022-09-22

Active, closed

The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE)

NCT05540327Systemic Lupus Erythematosus

DrugEnpatoran

Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

Phase 2

379

California, Florida, Indiana, Michigan, Minnesota, Ohio, Tennessee

2022-09-16

Recruiting

Proof of Concept Study to Eval MetriDx Lab-developed Test to Identify Endometriosis-specific Bio Markers

NCT05698212Endometriosis, Diagnosis

Hera Biotech, Inc.

Phase 2

Michigan, Texas

2022-09-14

Active, closed

A Study of Guselkumab Therapy in Participants With Moderately to Severely Active Ulcerative Colitis

NCT05528510Colitis, Ulcerative

DrugsGuselkumab 1·Guselkumab 2·Guselkumab 3

Janssen Research & Development, LLC

Phase 3

418

Arizona, California, Colorado, Florida, Georgia, Kansas, Michigan, New York

2022-09-13

Recruiting

AngelMed Guardian® System PMA Post Approval Study

NCT05412927Acute Coronary Syndrome

Angel Medical Systems

Observational

500

Arizona, California, Florida, Georgia, Louisiana, Michigan, Oklahoma, Texas

2022-09-07

Recruiting

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

NCT05489211Endometrial Cancer, Gastric Cancer, Metastatic Castration-resistant Prostate Cancer, Ovarian Cancer

DrugsPrednisone/Prednisolone·Volrustomig·Rilvegostomig·Dato-DXd

AstraZeneca

Phase 2

454

California, Indiana, Kansas, Massachusetts, Michigan, New Jersey, New Mexico, New York

2022-09-06

Recruiting

Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial

NCT05334368Hypereosinophilic Syndrome

DrugDepemokimab

GlaxoSmithKline

Phase 3

109

California, Georgia, Massachusetts, Michigan, Minnesota, New York, Ohio, South Carolina

2022-09-06

Recruiting

TVMR With the INNOVALVE System Trial - Early Feasibility Study

NCT04919980Mitral Valve Regurgitation (Degenerative or Functional)

Edwards Lifesciences

Not applicable

California, Florida, Georgia, Illinois, Michigan, Minnesota, Missouri, New Jersey

2022-09-01

Recruiting

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

NCT05533697Advanced Solid Tumors

DrugsIpilimumab·Nivolumab·Pembrolizumab

ModernaTX, Inc.

Phase 1/2

361

California, Colorado, District of Columbia, Florida, Illinois, Massachusetts, Michigan, Missouri

2022-09-01

Recruiting

Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.

NCT05422911Metastatic Cancer, Neoplasm, Prostate, Castrate-sensitive, Castrate-sensitive Prostate Cancer

DrugsZytiga·Apalutamide·Xtandi·Abiraterone acetate

Sun Pharmaceutical Industries Limited

Phase 2

192

California, Florida, Michigan, Missouri, New York, North Carolina, Oregon, Pennsylvania

2022-08-31

Active, closed

Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

NCT05508906Metastatic Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, Breast Cancer

DrugsPalazestrant·Atirmociclib·Alpelisib·Everolimus

Olema Pharmaceuticals, Inc.

Phase 1

190

Arizona, California, Colorado, Florida, Iowa, Massachusetts, Michigan, Minnesota

2022-08-31

Recruiting

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

NCT05281471Platinum-resistant Ovarian Cancer, Platinum-refractory Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer

DrugsOlvimulogene nanivacirepvec·Pegylated liposomal doxorubicin·Nab-paclitaxel·Bevacizumab

Genelux Corporation

Phase 3

186

Alabama, Arizona, California, Florida, Georgia, Indiana, Maryland, Michigan

2022-08-31

Recruiting

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

NCT05386108Breast Neoplasms, Brain Neoplasms, Neoplasms by Site, Neoplasms

DrugsElacestrant·Abemaciclib

Stemline Therapeutics, Inc.

Phase 1/2

California, Illinois, Massachusetts, Michigan, Ohio, Oregon, Tennessee, Texas

2022-08-31

Active, closed

BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease

NCT05456880Sickle Cell Disease

Beam Therapeutics Inc.

Phase 1/2

Alabama, Arizona, Florida, Georgia, Massachusetts, Michigan, Minnesota, Missouri

2022-08-30

Active, closed

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease

NCT05271409Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)

DrugSatralizumab

Hoffmann-La Roche

Phase 3

132

Alabama, California, Colorado, District of Columbia, Florida, Maryland, Massachusetts, Michigan

2022-08-30

Recruiting

Asciminib Roll-over Study

NCT04877522Chronic Myelogenous Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive

DrugsAsciminib single agent·Bosutinib·ABL001·Nilotinib

Novartis Pharmaceuticals

Phase 4

347

Michigan, New York, Oregon, Texas, Wisconsin

2022-08-30

Recruiting

Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer

NCT05455619HR+/HER2-negative Breast Cancer, Metastatic Breast Cancer

SynDevRx, Inc.

Phase 1/2

California, Florida, Illinois, Michigan, Ohio, Pennsylvania, Tennessee, Texas

2022-08-26

Active, closed

First-Line Tarlatamab in Combination With Carboplatin, Etoposide, and PD-L1 Inhibitor in Subjects With Extensive Stage Small Cell Lung Cancer (ES-SCLC)

NCT05361395Extensive Stage Small Cell Lung Cancer

DrugsTarlatamab·Tecentriq·Etoposide·Atezolizumab

Amgen

Phase 1

184

California, Delaware, Michigan, New Jersey, New York, North Carolina, South Dakota, Washington

2022-08-24

Active, closed

Safety and Efficacy of ADVM-022 in Treatment-Experienced Patients With Neovascular Age-related Macular Degeneration [LUNA]

NCT05536973Neovascular Age-related Macular Degeneration

Adverum Biotechnologies, Inc.

Phase 2

Arizona, California, Colorado, Connecticut, Florida, Hawaii, Michigan, Mississippi

2022-08-23

Recruiting

BP1001-A in Patients With Advanced or Recurrent Solid Tumors

NCT04196257Solid Tumor, Adult, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Endometrial Cancer

Bio-Path Holdings, Inc.

Phase 1

Maryland, Michigan, Texas

2022-08-19

Recruiting

A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments

NCT05137054Multiple Myeloma

DrugsNirogacestat·Cevostamab·Fianlimab·Linvoseltamab

Regeneron Pharmaceuticals

Phase 1

317

California, Georgia, Indiana, Massachusetts, Michigan, Minnesota, New York, North Carolina

2022-08-17

Active, closed

GammaTile and Stupp in Newly Diagnosed GBM

NCT05342883Glioblastoma

GT Medical Technologies, Inc.

Phase 4

Arizona, California, Florida, Georgia, Illinois, Indiana, Kansas, Michigan

2022-08-17

Recruiting

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

NCT05377996Triple Negative Breast Cancer, Breast Cancer, Endometrial Cancer, Ovarian Cancer

Day One Biopharmaceuticals, Inc.

Phase 1/2

360

Arizona, California, Florida, Georgia, Illinois, Massachusetts, Michigan, Minnesota

2022-08-15

Active, closed

A Study of Ivaltinostat Plus Capecitabine or Capecitabine in Metastatic Pancreatic Adenocarcinoma

NCT05249101Metastatic Pancreatic Adenocarcinoma

DrugsXeloda·Capecitabine

CG Pharmaceuticals, Inc

Phase 1/2

Arizona, California, Georgia, Indiana, Kentucky, Louisiana, Michigan, New York

2022-08-15

Recruiting

Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer

NCT05254171Pancreatic Cancer Metastatic, Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer Stage IV

DrugsAbraxane·Nab-paclitaxel·Gemcitabine

Panbela Therapeutics, Inc.

Phase 2/3

600

Arkansas, California, Connecticut, District of Columbia, Michigan, Minnesota, New York, Ohio

2022-08-08

Active, closed

A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer

NCT05388669Advanced or Metastatic Non-small Cell Lung Cancer

DrugsLazertinib·Amivantamab

Janssen Research & Development, LLC

Phase 3

418

California, Colorado, Florida, Kansas, Michigan, New Jersey, New York, Oregon

2022-08-05

Recruiting

A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation

NCT05410145KRAS P.G12C

DrugsD3S-001·Cetuximab·Pemetrexed·Cisplatin

D3 Bio (Wuxi) Co., Ltd

Phase 1/2

442

California, Colorado, Florida, Michigan, Tennessee, Texas

2022-08-03

Active, closed

A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation

NCT05485974Lung Cancer, Non Small Cell Lung Cancer, Colorectal Cancer, Cancer of Pancreas

HUYABIO International, LLC.

Phase 1

California, Florida, Michigan, Missouri, Ohio

2022-08-01

Active, closed

Clinical Trial to Evaluate the Safety and Efficacy of DWN12088 in Patients With IPF

NCT05389215Idiopathic Pulmonary Fibrosis

Daewoong Pharmaceutical Co. LTD.

Phase 2

102

Arizona, California, Illinois, Kansas, Massachusetts, Michigan, Missouri, North Carolina

2022-07-29

Recruiting

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

NCT05379595Advanced or Metastatic Colorectal Cancer

DrugsAmivantamab·Fluorouracil·Leucovorin·Irinotecan

Janssen Research & Development, LLC

Phase 1/2

225

Alabama, California, District of Columbia, Florida, Maryland, Michigan, Mississippi, New York

2022-07-29

Active, closed

A Study of XmAb20717 (Vudalimab)in Patients With Selected Advanced Gynecologic and Genitourinary Malignancies

NCT05032040Ovarian Cancer, Clear Cell Carcinoma, Endometrial Cancer, Cervical Carcinoma

Xencor, Inc.

Phase 2

170

Arizona, California, Colorado, Delaware, Florida, Georgia, Michigan, Nevada

2022-07-21

Recruiting

A Study of Nipocalimab in Children Aged 2 to Less Than 18 Years With Generalized Myasthenia Gravis

NCT05265273Myasthenia Gravis

DrugNipocalimab

Janssen Research & Development, LLC

Phase 2/3

Arizona, California, Colorado, Florida, Kansas, Michigan, Pennsylvania

2022-07-20

Active, closed

First-in-human Study of DB-1305/BNT325 for Advanced/Metastatic Solid Tumors

NCT05438329Advanced Solid Tumor

DrugsDB-1305/BNT325·Pumitamig

DualityBio Inc.

Phase 1/2

1,123

Arizona, California, District of Columbia, Florida, Hawaii, Illinois, Michigan, Nevada

2022-07-19

Active, closed

Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis

NCT05126277Lupus Nephritis

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

452

Alabama, California, Florida, Georgia, Louisiana, Michigan, Nevada, New York

2022-07-14

Active, closed

A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies

NCT05362773Leukemia, Acute Myeloid, Myelodysplastic Syndromes, Classical Hodgkin Lymphoma, Leukemia, B-cell

MacroGenics

Phase 1

130

Colorado, Maryland, Massachusetts, Michigan, Missouri, North Carolina, Texas

2022-07-13

Active, closed

A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE)

NCT05392114Hereditary Angioedema

DrugDonidalorsen

Ionis Pharmaceuticals, Inc.

Phase 3

154

Arizona, California, Florida, Kansas, Massachusetts, Michigan, Missouri, North Carolina

2022-07-13

Active, closed

Natural History of PRPF31 Mutation-Associated Retinal Dystrophy

NCT05573984Retinitis Pigmentosa, Eye Diseases, Hereditary, Retinal Dystrophies, Retinal Dystrophy Rod

PYC Therapeutics

Observational

California, Florida, Michigan, Oregon, Texas

2022-07-07

Active, closed

PDN Post Market, Multicenter, Prospective, Global Clinical Study

NCT05301816Diabetic Neuropathy, Painful

Nevro Corp

Not applicable

497

Alaska, Michigan, Ohio, Oklahoma, Oregon, Pennsylvania, Virginia

2022-07-05

Active, closed

A Study of Nipocalimab in Participants With Active Idiopathic Inflammatory Myopathies

NCT05379634Myositis

DrugNipocalimab

Janssen Research & Development, LLC

Phase 2

Arizona, California, Florida, Georgia, Kansas, Maryland, Massachusetts, Michigan

2022-07-05

Active, closed

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

NCT05355701Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma

DrugsPF-07799933·Binimetinib·Erbitux·Midazolam

Pfizer

Phase 1

103

Arkansas, Colorado, Florida, Massachusetts, Michigan, New Jersey, New York, Ohio

2022-07-05

Active, closed

Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutations

NCT05364073Non-Small Cell Lung Cancer (NSCLC), Metastatic Non-Small Cell Lung Cancer, Advanced Non-Small Cell Lung Cancer, HER2 Exon 20 Mutations

DrugFurmonertinib

ArriVent BioPharma, Inc.

Phase 1

160

Arizona, California, Florida, Michigan, Texas, Virginia

2022-06-30

Active, closed

Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies

NCT05316701Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Mixed Phenotype Acute Leukemia, Undifferentiated Leukemia

DrugOrca-T

Orca Biosystems, Inc.

Phase 3

187

California, Colorado, Florida, Georgia, Illinois, Massachusetts, Michigan, New York

2022-06-21

Recruiting

Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD

NCT05438732Age-Related Macular Degeneration, Geographic Atrophy

VisionCare, Inc.

Not applicable

125

California, Florida, Massachusetts, Michigan, Nebraska, New Jersey, North Carolina, Ohio

2022-06-16

Active, closed

Non-interventional Study on Osilodrostat in Patients With Endogenous Cushing's Syndrome

NCT05382156Endogenous Cushing's Syndrome

DrugOsilodrostat

RECORDATI GROUP

Observational

206

Arizona, Georgia, Illinois, Indiana, Kentucky, Massachusetts, Michigan, Minnesota

2022-06-13

By invitation

A Study to Learn More About the Long-Term Safety of Litifilimab (BIIB059) Injections and it's Effects on Symptoms in Adults With Systemic Lupus Erythematosus (SLE)

NCT05352919Systemic Lupus Erythematosus (SLE)

DrugLitifilimab

Biogen

Phase 3

864

Arizona, California, Colorado, District of Columbia, Florida, Georgia, Massachusetts, Michigan

2022-06-10

Recruiting

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

NCT05245500Mesothelioma, Non Small Cell Lung Cancer, Malignant Peripheral Nerve Sheath Tumors, Solid Tumor

DrugNavlimetostat

Bristol-Myers Squibb

Phase 1

336

Arizona, Colorado, Florida, Illinois, Massachusetts, Michigan, Minnesota, New Jersey

2022-06-09

Recruiting

A Study of ASP3082 in Adults With Advanced Solid Tumors

NCT05382559Solid Tumor

DrugsNanoparticle albumin-bound-paclitaxel·Setidegrasib·Liposomal Irinotecan·Fluorouracil

Astellas Pharma Inc

Phase 1

681

California, Colorado, Connecticut, District of Columbia, Florida, Kansas, Massachusetts, Michigan

2022-06-08

Recruiting

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

NCT05320198Myelofibrosis; Anemia, Anemia, Myelofibrosis, Myelofibrosis Due to and Following Polycythemia Vera

DrugDISC-0974

Disc Medicine, Inc

Phase 1/2

150

Arizona, California, Colorado, Florida, Georgia, Michigan, Minnesota, Missouri

2022-06-06

Active, closed

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Not Regularly Transfused, Followed by a 5-Year Extension Period

NCT05175105Pediatric Pyruvate Kinase Deficiency, Pediatric Hemolytic Anemia

DrugMitapivat

Agios Pharmaceuticals, Inc.

Phase 3

California, Colorado, Georgia, Illinois, Massachusetts, Michigan, North Carolina, Pennsylvania

2022-06-06

Active, closed

Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer

NCT05367440Metastatic Prostate Cancer

DrugsSaruparib·Zytiga·Apalutamide·Xtandi

AstraZeneca

Phase 1/2

174

Michigan, New York, South Carolina, Texas

2022-06-02

Recruiting

Study of ORIC-944 in Patients With Metastatic Prostate Cancer

NCT05413421Metastatic Prostate Cancer

DrugsDarolutamide (Nubeqa)·Rinzimetostat·Apalutamide (Erleada)

ORIC Pharmaceuticals

Phase 1

275

Colorado, Florida, Illinois, Indiana, Maryland, Michigan, Minnesota, New York

2022-06-01

Active, closed

A Study to Evaluate Safety, Efficacy of FF-10832 in Combo With Pembrolizumab in Urothelial & Non-small Cell Lung Cancer

NCT05318573Advanced Urothelial Carcinoma, Advanced Non Small Cell Lung Cancer

DrugsFF-10832·Keytruda·Pembrolizumab

Fujifilm Pharmaceuticals U.S.A., Inc.

Phase 2

120

California, District of Columbia, Kansas, Kentucky, Michigan, Missouri, Nebraska, Nevada

2022-06-01

Recruiting

S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Advanced or Metastatic Solid Tumors

NCT05101070Solid Tumors

DrugsAvastin·Keytruda·Bevacizumab·Pembrolizumab

Shionogi

Phase 1/2

282

California, Florida, Michigan, Pennsylvania, Texas

2022-05-30

Active, closed

Effect of Ensifentrine on Sputum Markers of Inflammation in COPD

NCT05270525COPD

Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA

Phase 2

Alabama, Michigan, Pennsylvania

2022-05-27

Recruiting

A Study of YL201 in Patients With Advanced Solid Tumors

NCT05434234Advanced Solid Tumor

DrugTam-Peli

MediLink Therapeutics (Suzhou) Co., Ltd.

Phase 1/2

312

California, Colorado, District of Columbia, Massachusetts, Michigan, Missouri, New Mexico, New York

2022-05-25

Active, closed

A Study to Assess the Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma Receiving Oral ABBV-453 Tablets

NCT05308654Relapsed/Refractory Multiple Myeloma

DrugsABBV-453·Daratumumab·Lenalidomide·Dexamethasone

AbbVie

Phase 1

California, Florida, Louisiana, Maryland, Michigan, Minnesota, New York, North Carolina

2022-05-17

Active, closed

A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)

NCT05374512Breast Cancer

DrugsEribulin·Dato-DXd·Nab-paclitaxel·Capecitabine

AstraZeneca

Phase 3

644

California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Kentucky, Michigan

2022-05-16

Active, closed

A.L.P.S. Clavicle Plating System PMCF

NCT05327959Clavicle Fracture, Clavicle Injury

Zimmer Biomet

Not applicable

Florida, Michigan, Oregon, Texas

2022-05-13

Active, closed

P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma

NCT04960579Multiple Myeloma

DrugsRimiducid·Methotrexate

Poseida Therapeutics, Inc.

Phase 1

275

Arizona, California, Georgia, Illinois, Iowa, Kansas, Maryland, Michigan

2022-05-05

Recruiting

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

NCT04879329Urothelial Carcinoma

DrugsDisitamab Vedotin·Keytruda·Pembrolizumab

Seagen, a wholly owned subsidiary of Pfizer

Phase 2

372

Arizona, California, District of Columbia, Florida, Georgia, Illinois, Massachusetts, Michigan

2022-05-03

Recruiting

Cephea Early Feasibility Study

NCT05061004Mitral Regurgitation

Abbott Medical Devices

Not applicable

Arizona, California, Georgia, Illinois, Kansas, Michigan, Minnesota, New York

2022-04-28

Active, closed

STOP AF First Post-Approval Study

NCT05227053Paroxysmal Atrial Fibrillation

Medtronic Cardiac Ablation Solutions

Observational

200

Alaska, Connecticut, District of Columbia, Florida, Iowa, Massachusetts, Michigan, Ohio

2022-04-28

Active, closed

Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients

NCT05074810Non Small Cell Lung Cancer, KRAS Activating Mutation

DrugLumakras

Verastem, Inc.

Phase 1/2

153

Colorado, District of Columbia, Illinois, Maryland, Massachusetts, Michigan, Minnesota, Missouri

2022-04-12

By invitation

Trial of Sibeprenlimab in the Treatment of Immunoglobulin A Nephropathy (IgAN)

NCT05248659Immunoglobulin A Nephropathy

DrugSibeprenlimab

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 2/3

600

Alabama, California, Colorado, Florida, Georgia, Massachusetts, Michigan, New York

2022-04-05

Recruiting

Safety and Tolerability of RPE Stem Cell-derived RPE(RPESC-RPE) Transplantation in Patients With Dry Age-related Macular Degeneration (AMD)

NCT04627428Dry Age-related Macular Degeneration

Luxa Biotechnology, LLC

Phase 1/2

California, Michigan

2022-04-05

Recruiting

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

NCT05267626Advanced Solid Tumor, Metastatic Cancer, Cutaneous Melanoma, Non-Small Cell Lung Cancer

DrugsAvelumab·Aldesleukin·Nivolumab

Aulos Bioscience, Inc.

Phase 1/2

159

Florida, Michigan, Minnesota, Missouri, North Carolina, Tennessee, Texas, Utah

2022-04-04

Active, closed

Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors

NCT05215574Pancreatic Cancer, Breast Cancer, Gastric Cancer, Non-small Cell Lung Cancer

DrugsKeytruda·Pembrolizumab

NGM Biopharmaceuticals, Inc

Phase 1

130

Arizona, California, Florida, Michigan, New York, Oklahoma, Texas

2022-03-31

Active, closed

Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)

NCT05270668Diffuse Cutaneous Systemic Sclerosis, Interstitial Lung Disease

DrugTulisokibart

Prometheus Biosciences, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 2

154

Arizona, California, Colorado, Connecticut, District of Columbia, Maryland, Massachusetts, Michigan

2022-03-29

Recruiting

Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)

NCT04895436Chronic Lymphocytic Leukemia (CLL)

DrugsVenclexta·Obinutuzumab·Venetoclax

AbbVie

Phase 2

California, Georgia, Iowa, Massachusetts, Michigan, Minnesota, Mississippi, New Jersey

2022-03-28

Active, closed

LF111 or Drospirenone Chew vs Non-hormonal Contraceptive Methods on Bone Mineral Density in Adolescent and Adult Women

NCT05303636Change in Bone Mineral Density, Bone Loss

DrugDrospirenone

Insud Pharma

Phase 4

1,536

Arizona, Colorado, Florida, Louisiana, Michigan, Nebraska, North Dakota, Pennsylvania

2022-03-28

Active, closed

Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant

NCT05317416Multiple Myeloma

DrugsElranatamab·Lenalidomide

Pfizer

Phase 3

854

Arizona, California, District of Columbia, Florida, Georgia, Illinois, Kansas, Michigan

2022-03-25

Active, closed

Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)

NCT05224141Small Cell Lung Carcinoma

DrugsPembrolizumab/Vibostolimab·Tecentriq·Paraplatin·Etoposide

Merck Sharp & Dohme LLC

Phase 3

460

Alabama, California, Florida, Indiana, Massachusetts, Michigan, Mississippi, Pennsylvania

2022-03-24

Active, closed

A Study to Evaluate the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Circulating Tumor (ct)DNA High-Risk Patients With Untreated Diffuse Large B-Cell Lymphoma

NCT04980222Lymphoma

DrugsGlofitamab·Tocilizumab·Vincristine·Doxorubicin

Hoffmann-La Roche

Phase 2

California, Iowa, Michigan, Missouri, New Jersey, New York, Texas

2022-03-22

Active, closed

A Study to Learn About the Study Medicine (Called PF-07220060 in Combination With PF-07104091) In Participants With Breast Cancer and Solid Tumors

NCT05262400Breast Cancer, Solid Tumors

DrugsPF-07104091·Atirmociclib

Pfizer

Phase 1/2

235

California, Massachusetts, Michigan, Missouri, Texas, Washington

2022-03-14

Active, closed

Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC)

NCT05280470Extensive-stage Small-cell Lung Cancer

DrugIfinatamab Deruxtecan

Daiichi Sankyo

Phase 2

187

Arkansas, Florida, Illinois, Maryland, Massachusetts, Michigan, Missouri, New Jersey

2022-03-09

Active, closed

A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.

NCT05064878CDKL5 Deficiency Disorder, Generalized Tonic Clonic Seizure, Epileptic Spasm, Refractory Seizures

DrugFintepla

Zogenix, Inc.

Phase 3

Alabama, California, Colorado, District of Columbia, Georgia, Massachusetts, Michigan, North Carolina

2022-03-08

Active, closed

INTIBIA Pivotal Study

NCT05250908Urinary Incontinence, Urge, Urinary Bladder, Overactive, Urinary Bladder Diseases, Urologic Diseases

Coloplast A/S

Not applicable

208

California, District of Columbia, Florida, Georgia, Idaho, Kansas, Massachusetts, Michigan

2022-03-07

Active, closed

A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

NCT05250973Amyloidosis

DrugsBortezomib·Daratumumab·Dexamethasone·Cyclophosphamide

Janssen Research & Development, LLC

Phase 2

151

California, Connecticut, Florida, Georgia, Massachusetts, Michigan, New York, North Carolina

2022-03-01

Active, closed

A Study to Investigate Faricimab Treatment Response in Treatment-Naive, Underrepresented Patients With Diabetic Macular Edema

NCT05224102Diabetic Macular Edema

DrugsVabysmo·Faricimab

Genentech, Inc.

Phase 4

218

Arizona, California, Colorado, District of Columbia, Florida, Illinois, Maryland, Michigan

2022-02-28

Active, closed

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Familial Chylomicronemia Syndrome (FCS) Previously Treated With Volanesorsen

NCT05185843Familial Chylomicronemia Syndrome

DrugOlezarsen

Ionis Pharmaceuticals, Inc.

Phase 3

California, Florida, Michigan, New York

2022-02-25

Active, closed

A Study to Evaluate ERAS-801 in Patients With Recurrent Glioblastoma (THUNDERBBOLT-1)

NCT05222802Glioblastoma Multiforme

Katmai Pharmaceuticals Inc.

Phase 1

California, Florida, Massachusetts, Michigan, New York, Ohio, Tennessee, Utah

2022-02-25

Active, closed

177Lu-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer

NCT05204927Metastasis From Malignant Tumor of Prostate

DrugEnzalutamide

Curium US LLC

Phase 3

439

Arizona, California, Florida, Illinois, Maryland, Michigan, Minnesota, Missouri

2022-02-14

Active, closed

A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer

NCT05221840Non-Small Cell Lung Cancer

DrugsMonalizumab·Oleclumab·Durvalumab

AstraZeneca

Phase 3

1,051

California, Connecticut, Florida, Illinois, Indiana, Kentucky, Maryland, Michigan

2022-02-07

Active, closed

A Study of Anvumetostat in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)

NCT05094336Advanced MTAP-null Solid Tumors

DrugsAnvumetostat·Docetaxel

Amgen

Phase 1/2

329

California, Florida, Indiana, Maryland, Michigan, Missouri, New Jersey, New York

2022-02-01

Active, closed

A Study to Learn About the Effect of Higher Doses of Nusinersen (BIIB058) Given as Injections to Participants With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Risdiplam (ASCEND)

NCT05067790Spinal Muscular Atrophy

DrugNusinersen

Biogen

Phase 3

Arizona, California, Georgia, Massachusetts, Michigan, New York, North Carolina, Pennsylvania

2022-01-21

Recruiting

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

NCT05139017DLBCL, Diffuse Large B-Cell Lymphoma

DrugsZilovertamab vedotin·Granulocyte Colony-Stimulating Factor·Riabni·Ruxience

Merck Sharp & Dohme LLC

Phase 2/3

290

Arizona, California, Florida, Illinois, Kentucky, Maryland, Massachusetts, Michigan

2022-01-14

Recruiting

A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

NCT05118789Locally Advanced Solid Tumor, Metastatic Solid Tumor

Nuvalent Inc.

Phase 1/2

359

California, Colorado, District of Columbia, Florida, Illinois, Massachusetts, Michigan, Missouri

2022-01-04

Active, closed

A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies

NCT05199272Solid Tumor, Clear Cell Renal Cell Carcinoma, Epithelial Ovarian Cancer, Fallopian Tube Cancer

23andMe, Inc.

Phase 1/2

141

California, Georgia, Michigan, New York, Oregon, Tennessee, Texas, Virginia

2021-12-29

Active, closed

A Study to Assess Disease Activity and Safety of Subcutaneous Lutikizumab (ABT-981) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-Tumor Necrosis Factor (TNF) Therapy and Who Are Naïve to Biologic Therapy

NCT05139602Hidradenitis Suppurativa

DrugLutikizumab

AbbVie

Phase 2

210

Arizona, Arkansas, California, Connecticut, Florida, Indiana, Massachusetts, Michigan

2021-12-28

Active, closed

Long - Term Follow Up of Sickle Cell Disease and Beta-thalassemia Subjects Previously Exposed to BIVV003 or ST-400.

NCT05145062Blood and Lymphatic Diseases

Sangamo Therapeutics

Observational

California, Georgia, Massachusetts, Michigan, Minnesota

2021-12-21

Active, closed

Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer

NCT04905069Prostate Cancer

Boston Scientific Corporation

Not applicable

500

Florida, Kansas, Michigan, New Jersey, Pennsylvania, South Carolina

2021-12-21

Active, closed

A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis

NCT05197036Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis

Smith & Nephew, Inc.

Observational

299

Georgia, Massachusetts, Michigan, New York, North Carolina, Oregon, South Carolina, Tennessee

2021-12-21

Active, closed

Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.

NCT05123755Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral

Vasomune Therapeutics, Inc.

Phase 2

California, Colorado, Illinois, Maryland, Michigan, Ohio

2021-12-20

Active, closed

Study to Evaluate the Safety and Efficacy of Daily Subcutaneous Metreleptin Treatment in Subjects With PL

NCT05164341Partial Lipodystrophy

DrugMetreleptin

Chiesi Farmaceutici S.p.A.

Phase 3

Alabama, California, Florida, Georgia, Massachusetts, Michigan, Minnesota, Missouri

2021-12-17

Recruiting

A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

NCT05067283Advanced Solid Tumors

DrugsCalderasib·Leucovorin·Cetuximab·Adrucil

Merck Sharp & Dohme LLC

Phase 1

830

Florida, Michigan, New Jersey, New York, Virginia, Wisconsin

2021-12-17

Active, closed

Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)

NCT04954859Hepatitis B

DrugBepirovirsen

GlaxoSmithKline

Phase 2

360

California, Colorado, Massachusetts, Michigan

2021-12-14

Active, closed

A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis

NCT05070858Generalized Myasthenia Gravis

DrugsCemdisiran·Pozelimab

Regeneron Pharmaceuticals

Phase 3

288

Arizona, California, Colorado, Florida, Illinois, Michigan, Ohio, Pennsylvania

2021-12-14

Active, closed

Safety, Pharmacokinetics and Clinical Activity of AZD0171 in Combination With Durvalumab and Chemotherapy in Locally Advanced or Metastatic Solid Tumours

NCT04999969Locally Advanced or Metastatic Solid Tumours

DrugsAZD0171·Durvalumab·Nab-paclitaxel·Gemcitabine

AstraZeneca

Phase 2

126

California, Georgia, Idaho, Massachusetts, Michigan, New York, Oregon, Texas

2021-12-10

Active, closed

Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

NCT05079282Relapsed or Refractory T Cell Lymphoma

DrugONO-4685

Ono Pharmaceutical Co., Ltd.

Phase 1

217

Alabama, California, Connecticut, Georgia, Massachusetts, Michigan, Missouri, New Jersey

2021-12-10

Active, closed

Prospective Case Collection Study for New Mammography Technologies

NCT05199701Mammography

Hologic, Inc.

Not applicable

7,500

Arizona, Florida, Kentucky, Maryland, Michigan, New York, North Carolina, Ohio

2021-12-10

Active, closed

NP-G2-044 as Monotherapy and Combination Therapy in Patients With Advanced or Metastatic Solid Tumor Malignancies

NCT05023486Advanced or Metastatic Solid Tumor Malignancies

DrugPrilukae

Novita Pharmaceuticals, Inc.

Phase 1/2

121

Arizona, Arkansas, California, Connecticut, Florida, Indiana, Kansas, Michigan

2021-12-07

Recruiting

A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine

NCT05164172Migraine

DrugEptinezumab

H. Lundbeck A/S

Phase 3

600

Connecticut, Florida, Kentucky, Maryland, Michigan, New York, North Carolina, Ohio

2021-12-01

Active, closed

A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC)

NCT05060016Relapsed/Refractory Small Cell Lung Cancer

DrugTarlatamab

Amgen

Phase 2

222

Alabama, Arkansas, Delaware, Florida, Georgia, Iowa, Massachusetts, Michigan

2021-12-01

Recruiting

(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

NCT04910685Indolent Systemic Mastocytosis, Smoldering Systemic Mastocytosis

Blueprint Medicines Corporation

Phase 2/3

534

Alabama, California, Colorado, Georgia, Massachusetts, Michigan, Minnesota, New York

2021-11-30

Active, closed

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)

NCT04770779Transfusion-dependent Alpha-Thalassemia, Transfusion-dependent Beta-Thalassemia

DrugMitapivat

Agios Pharmaceuticals, Inc.

Phase 3

258

Arizona, California, Massachusetts, Michigan, New York, North Carolina, Pennsylvania, Washington

2021-11-30

Active, closed

A Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab in Participants With Extensive-Stage Small-Cell Lung Cancer

NCT05091567Small-Cell Lung Cancer

DrugsLurbinectedin·Tecentriq·Etoposide·Atezolizumab

Hoffmann-La Roche

Phase 3

660

Georgia, Illinois, Maine, Massachusetts, Michigan, New York, Ohio, Rhode Island

2021-11-18

Active, closed

A Study of TAK-007 in Adults With Relapsed or Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL)

NCT05020015Relapsed or Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL)

Takeda

Phase 2

Alabama, California, District of Columbia, Florida, Georgia, Illinois, Michigan, New York

2021-11-12

Recruiting

A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study

NCT05130437Propionic Acidemia

DrugMRNA-3927

ModernaTX, Inc.

Phase 1/2

California, Michigan, New York, North Carolina, Pennsylvania, Texas

2021-11-09

Active, closed

A Study of NDI 1150-101 in Patients With Solid Tumors

NCT05128487Solid Tumor, Renal Cell Carcinoma (Kidney Cancer), Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma, Non-Small Cell Lung Cancer

DrugPembrolizumab

Nimbus Saturn, Inc.

Phase 1/2

106

Arizona, Connecticut, District of Columbia, Florida, Kentucky, Maryland, Michigan, Minnesota

2021-11-05

Recruiting

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

NCT05005403Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Micro Satellite Stable Colorectal Cancer, Gastric/Esophageal Cancer

DrugsBudigalimab·Telisotuzumab Adizutecan·Bevacizumab

AbbVie

Phase 1

694

California, Illinois, Indiana, Kentucky, Michigan, Minnesota, Nebraska, North Carolina

2021-11-01

Active, closed

A Study of CLN-619 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors

NCT05117476Advanced Solid Tumor, NSCLC

DrugsCLN-619·Carboplatin (AUC 6)·Dato-DXd·Pemetrexed

Cullinan Therapeutics Inc.

Phase 1

440

Alabama, California, Florida, Massachusetts, Michigan, New Jersey, New York, North Carolina

2021-10-29

Active, closed

A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations

NCT05048797Locally Advanced or Metastatic Non-Small Cell Lung Cancer

DrugsTrastuzumab deruxtecan·Pemetrexed·Cisplatin·Carboplatin

AstraZeneca

Phase 3

454

Alaska, California, Maryland, Massachusetts, Michigan, New Jersey, New York, Pennsylvania

2021-10-28

Active, closed

A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma

NCT04712097Relapsed or Refractory Follicular Lymphoma

DrugsMosunetuzumab·Lenalidomide·Rituximab

Hoffmann-La Roche

Phase 3

478

California, Georgia, Indiana, Maryland, Michigan, Missouri, New York, North Carolina

2021-10-27

Active, closed

A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus

NCT04963296Systemic Lupus Erythematosus

DrugsAcetaminophen/paracetamol·Diphenhydramine hydrochloride·Methylprednisolone·Obinutuzumab

Hoffmann-La Roche

Phase 3

303

Alabama, Arkansas, California, Florida, Michigan, New York, North Carolina, Ohio

2021-10-26

Active, closed

Harmony TPV Post-Approval Study

NCT05077774Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation

Medtronic Cardiovascular

Not applicable

174

Alabama, California, Colorado, Florida, Illinois, Massachusetts, Michigan, Missouri

2021-10-25

Recruiting

First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)

NCT05099172Advanced Non-small Cell Lung Cancer, EGFR Mutation, HER2 Mutation

Bayer

Phase 1/2

400

Arizona, California, Georgia, Maryland, Massachusetts, Michigan, New York, Tennessee

2021-10-25

Active, closed

A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)

NCT05104866Breast Cancer

DrugsEribulin·Dato-DXd·Vinorelbine·Capecitabine

AstraZeneca

Phase 3

732

California, Florida, Georgia, Massachusetts, Michigan, New York, Ohio, Oregon

2021-10-18

Active, closed

OCS Liver Perfusion (OLP) Post-Approval Registry

NCT05074160Liver Transplant

TransMedics

Observational

166

Alabama, California, Georgia, Massachusetts, Michigan, Nebraska, North Carolina, Texas

2021-10-14

Active, closed

A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma

NCT05083169Multiple Myeloma

DrugsTeclistamab·Pomalidomide·Bortezomib·Daratumumab

Janssen Research & Development, LLC

Phase 3

587

Alabama, California, Connecticut, Georgia, Massachusetts, Michigan, Ohio, Pennsylvania

2021-10-14

Recruiting

US National OCS Liver Perfusion (OLP) Registry

NCT05940857Liver Transplant

TransMedics

Observational

100,000

Alabama, Arizona, California, Florida, Georgia, Kentucky, Massachusetts, Michigan

2021-10-14

Active, closed

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab

NCT05029882Non-Small Cell Lung Cancer, Advanced Solid Tumors, Gastroesophageal Adenocarcinoma, Colorectal Cancer

DrugsTelisotuzumab Adizutecan·Trifluridine/Tipiracil·Bevacizumab

AbbVie

Phase 1

520

California, Colorado, Connecticut, Illinois, Indiana, Louisiana, Michigan, New York

2021-10-13

Active, closed

A Phase 1/2/3 Study of UX701 Gene Therapy in Adults With Wilson Disease

NCT04884815Wilson Disease

Ultragenyx Pharmaceutical Inc

Phase 1/2

California, Illinois, Indiana, Massachusetts, Michigan, North Carolina, Ohio, Tennessee

2021-09-27

Active, closed

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors

NCT04774718ALK Fusion-positive Solid or CNS Tumors

DrugAlectinib

Hoffmann-La Roche

Phase 1/2

California, Florida, Michigan, Minnesota, New York, Ohio, Tennessee

2021-09-14

Active, closed

A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes

NCT04747431Frontotemporal Dementia, FTD, FTD-GRN, Dementia Frontotemporal

Passage Bio, Inc.

Phase 1/2

Michigan, Pennsylvania, Tennessee, Texas

2021-09-14

Active, closed

OCS Heart Perfusion Post-Approval Registry

NCT05047068Transplant

TransMedics

Observational

350

California, Connecticut, Florida, Georgia, Illinois, Kentucky, Massachusetts, Michigan

2021-09-13

Recruiting

ZEN003694 and Enzalutamide Versus Enzalutamide Monotherapy in Metastatic Castration-Resistant Prostate Cancer

NCT04986423Metastatic Castration-Resistant Prostate Cancer

DrugsZEN003694·Xtandi·Enzalutamide

Zenith Epigenetics

Phase 2

200

California, Colorado, Florida, Louisiana, Maryland, Michigan, New York, North Carolina

2021-09-08

Active, closed

A Phase I/II Study of VTX-801 in Adult Patients With Wilson's Disease

NCT04537377Wilson's Disease

Vivet Therapeutics SAS

Phase 1/2

California, Connecticut, Florida, Michigan, North Carolina, Texas

2021-09-03

Active, closed

A Study of ARV-766 Given by Mouth in Men With Metastatic Prostate Cancer

NCT05067140Prostate Cancer Metastatic

DrugsLuxdegalutamide·Abiraterone·Prednisolone·Prednisone

Novartis Pharmaceuticals

Phase 1/2

164

California, Connecticut, Florida, Maryland, Massachusetts, Michigan, New York, Pennsylvania

2021-09-02

Recruiting

Effect of Early Administration of TXA in Adult Hip Fractures

NCT05047133Postoperative Blood Loss

DrugTranexamic Acid

Ascension Health

Phase 2/3

170

Michigan

2021-09-01

Active, closed

A Study of AL102 in Patients With Progressing Desmoid Tumors

NCT04871282Desmoid, Desmoid Tumor

Immunome, Inc.

Phase 2/3

198

Arizona, California, Florida, Illinois, Massachusetts, Michigan, Missouri, New York

2021-09-01

Active, closed

A Study of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active Psoriatic Arthritis Axial Disease

NCT04929210Arthritis, Psoriatic

DrugsTremfya·Guselkumab

Janssen Research & Development, LLC

Phase 4

411

Arizona, Arkansas, California, Connecticut, Florida, Illinois, Maryland, Michigan

2021-08-30

Recruiting

A Beta-only IL-2 ImmunoTherapY Study

NCT05086692Advanced Solid Tumor, Unresectable Solid Tumor, Clear Cell Renal Cell Carcinoma, Triple Negative Breast Cancer

DrugsKeytruda·Pembrolizumab

Medicenna Therapeutics, Inc.

Phase 1/2

115

California, Florida, Georgia, Michigan, Texas

2021-08-27

Active, closed

MElanoma Research Lymph Node Prediction Implementation National_001

NCT04759781Melanoma

SkylineDx

Observational

1,820

Florida, Georgia, Kentucky, Michigan, Minnesota, New York, North Carolina, Utah

2021-08-25

Active, closed

STOP Persistent AF PAS

NCT05005949Persistent Atrial Fibrillation

Medtronic Cardiac Ablation Solutions

Observational

400

Connecticut, Florida, Illinois, Michigan, Ohio, Texas

2021-08-19

Active, closed

A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy

NCT04923893Multiple Myeloma

DrugsCilta-cel·Bortezomib·Lenalidomide·Fludarabine

Janssen Research & Development, LLC

Phase 3

743

California, Connecticut, Florida, Iowa, Kentucky, Maryland, Massachusetts, Michigan

2021-08-19

Active, closed

Pembrolizumab Plus Lenvatinib in Combination With Belzutifan in Solid Tumors (MK-6482-016)

NCT04976634Neoplasm Malignant

DrugsBelzutifan·Lenvatinib·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 2

730

Arizona, California, Connecticut, District of Columbia, Florida, Maryland, Michigan, New York

2021-08-18

Active, closed

A Study of Penpulimab (AK105) in the First-line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma

NCT04974398Nasopharyngeal Carcinoma

DrugsPenpulimab·Cisplatin/Carboplatin·Gemcitabine

Akeso

Phase 3

296

California, Georgia, Michigan, New York

2021-08-16

Recruiting

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

NCT04924075Pheochromocytoma/Paraganglioma, Pancreatic Neuroendocrine Tumor, Von Hippel-Lindau Disease, Advanced Gastrointestinal Stromal Tumor

DrugBelzutifan

Merck Sharp & Dohme LLC

Phase 2

355

California, Illinois, Iowa, Maryland, Massachusetts, Michigan, Missouri, New York

2021-08-12

Recruiting

Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases

NCT05003986Focal Segmental Glomerulosclerosis, Minimal Change Disease, Immunoglobulin A Nephropathy, IgA Vasculitis

DrugSparsentan

Travere Therapeutics, Inc.

Phase 2

California, Delaware, Florida, Iowa, Massachusetts, Michigan, Minnesota, Missouri

2021-08-12

Recruiting

64Cu-SAR-bisPSMA and 67Cu-SAR-bisPSMA for Identification and Treatment of PSMA-expressing Metastatic Castrate Resistant Prostate Cancer (SECuRE)

NCT04868604Prostatic Neoplasms, Castration-Resistant

Drug64Cu-SAR-bisPSMA

Clarity Pharmaceuticals Ltd

Phase 1/2

California, Louisiana, Michigan, Minnesota, Missouri, Nebraska, New York

2021-08-11

Active, closed

Extension Study to Evaluate Safety and Tolerability of Oral Dersimelagon (MT-7117) in Subjects With Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP)

NCT05005975EPP, XLP

Tanabe Pharma America, Inc.

Phase 3

286

California, Florida, Massachusetts, Michigan, Missouri, New York, North Carolina, Ohio

2021-08-10

Recruiting

A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

NCT04939610Solid Tumor

Drug177Lu-FAP-2286

Novartis Pharmaceuticals

Phase 1/2

222

Alabama, California, Florida, Illinois, Iowa, Michigan, Minnesota, Missouri

2021-07-30

Active, closed

Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Isatuximab in Participants With RRMM

NCT07217184Multiple Myeloma

DrugsBelantamab mafodotin·Isatuximab

GlaxoSmithKline

Phase 1/2

Georgia, Massachusetts, Michigan, Wisconsin

2021-07-29

Recruiting

Zimmer Biomet Shoulder Arthroplasty PMCF

NCT04984291Shoulder Fractures, Shoulder Arthritis, Shoulder Osteoarthritis, Shoulder Deformity

Zimmer Biomet

Not applicable

584

California, Colorado, Illinois, Kentucky, Michigan, Minnesota, Mississippi, Missouri

2021-07-28

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT04910568Multiple Myeloma

DrugsCevostamab·Pomalidomide·Tocilizumab·Daratumumab

Genentech, Inc.

Phase 1

186

California, Colorado, Georgia, Michigan, Missouri

2021-07-26

Active, closed

A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment

NCT04908189Psoriatic Arthritis

DrugsApremilast·Deucravacitinib

Bristol-Myers Squibb

Phase 3

729

Alabama, California, Illinois, Kentucky, Louisiana, Maryland, Michigan, Minnesota

2021-07-15

Active, closed

A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases

NCT04554914Epstein-Barr Virus (EBV)-Associated Diseases, EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD), EBV+ Lymphoproliferative Disease With Acquired (Non-congenital) Immunodeficiency (EBV+ AID LPD), EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD)

DrugTabelecleucel

Pierre Fabre Medicament

Phase 2

190

California, Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan, Minnesota

2021-07-14

Recruiting

Valved Graft PMCF Study

NCT04754217Aortic Valve Disease, Ascending Aorta Abnormality, Aortic Dissection

Abbott Medical Devices

Observational

260

Alabama, Michigan, North Carolina, Pennsylvania

2021-07-13

Active, closed

Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome.

NCT05018286Short Bowel Syndrome

DrugApraglutide

VectivBio AG

Phase 3

158

California, Florida, Illinois, Michigan, Minnesota, Nebraska, New York, North Carolina

2021-07-13

Active, closed

A Study to Evaluate Efficacy and Safety of Deucravacitinib in Participants With Active Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE)

NCT04857034Lupus Erythematosus, Discoid, Lupus Erythematosus, Subacute Cutaneous

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 2

Arizona, California, Connecticut, Florida, Michigan, Missouri, New York, North Carolina

2021-07-12

Active, closed

Triathlon All-Polyethylene Tibia Outcomes Study

NCT04636190Arthropathy of Knee, Replacement, Knee Arthritis

Stryker Orthopaedics

Not applicable

204

Michigan, New York, North Carolina, Ohio, Texas

2021-07-02

Active, closed

Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting

NCT04900844Carotid Artery Stenosis

InspireMD

Not applicable

317

Florida, Louisiana, Michigan, Missouri, New York, North Carolina, Ohio, Pennsylvania

2021-07-01

Recruiting

A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine

NCT04965675Chronic Migraine in Children

DrugEptinezumab

H. Lundbeck A/S

Phase 3

285

Connecticut, District of Columbia, Florida, Georgia, Kentucky, Maryland, Michigan, New York

2021-06-30

Active, closed

Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease

NCT04915755Neoplasms, Breast

DrugNiraparib

GlaxoSmithKline

Phase 3

California, Colorado, Illinois, Michigan, New Mexico, New York, North Dakota, Pennsylvania

2021-06-28

Active, closed

A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy

NCT04629248Primary Membranous Nephropathy

DrugsDiphenhydramine·Acetaminophen·Tacrolimus·Methylprednisolone

Hoffmann-La Roche

Phase 3

142

California, Colorado, Florida, Iowa, Michigan, Minnesota, New York, Texas

2021-06-25

Active, closed

A Study of Guselkumab in Participants With Active Psoriatic Arthritis

NCT04882098Arthritis, Psoriatic

DrugGuselkumab

Janssen Research & Development, LLC

Phase 3

1,054

Alabama, Arizona, California, Florida, Maryland, Michigan, Missouri, Montana

2021-06-17

Recruiting

Persona Revision Knee System Outcomes

NCT04821154Arthroplasty Complications, Infection, Knee Disease, Knee Osteoarthritis

Zimmer Biomet

Observational

380

Arkansas, California, Colorado, Indiana, Kentucky, Michigan, Minnesota, Missouri

2021-06-14

Active, closed

HER3-DXd (Patritumab Deruxtecan; U3-1402) in Combination With Osimertinib in Subjects With Locally Advanced or Metastatic EGFR-mutated Non-Small Cell Lung Cancer

NCT04676477Non-Small Cell Lung Cancer (NSCLC)

DrugsPatritumab deruxtecan·Osimertinib

Daiichi Sankyo

Phase 1

246

California, Connecticut, District of Columbia, Illinois, Massachusetts, Michigan, New Hampshire, New York

2021-06-11

Active, closed

Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus

NCT04877691Systemic Lupus Erythematosus

DrugAnifrolumab

AstraZeneca

Phase 3

367

Alabama, Arizona, California, Colorado, Florida, Idaho, Michigan, New Jersey

2021-06-08

Active, closed

da Vinci SP® Investigational Device Exemption Study in Colorectal Procedures

NCT04403022Colorectal Cancer, Benign or Malignant Rectal or Colon Tumors

Intuitive Surgical

Not applicable

Florida, Michigan, Minnesota, Nevada, Pennsylvania, Texas, Washington

2021-06-03

Active, closed

A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus

NCT04895241Lupus Erythematosus, Systemic

DrugLitifilimab

Biogen

Phase 3

548

Alabama, California, Colorado, District of Columbia, Florida, Georgia, Louisiana, Michigan

2021-05-25

Active, closed

Once Daily Versus Twice Daily Budesonide Orodispersible Tablets for Induction of Remission in EoE

NCT06596252Eosinophilic Esophagitis

DrugBudesonide

Dr. Falk Pharma GmbH

Phase 3

308

Arizona, Arkansas, California, Florida, Idaho, Massachusetts, Michigan, Minnesota

2021-05-21

Recruiting

A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)

NCT04811560Acute Leukemia

DrugBleximenib

Janssen Research & Development, LLC

Phase 1/2

420

California, Illinois, Indiana, Kentucky, Massachusetts, Michigan, New Mexico, New York

2021-05-19

Recruiting

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

NCT04614103Metastatic Non Small Cell Lung Cancer

Iovance Biotherapeutics, Inc.

Phase 2

170

Arizona, Florida, Illinois, Kentucky, Maryland, Michigan, Minnesota, Nebraska

2021-05-07

Active, closed

ARX517/JNJ-95298177 as Monotherapy or Combination Therapy in Subjects With Metastatic Prostate Cancer

NCT04662580Metastatic Prostate Cancer

DrugsARX517·Apalutamide·Abiraterone acetate·Prednisone

Janssen Research & Development, LLC

Phase 1

183

California, Georgia, Indiana, Michigan, Missouri, Nebraska, New York, Ohio

2021-05-03

Recruiting

Study of Lunresertib Alone or in Combination With RP-3500 or Debio 0123 in Patients With Advanced Solid Tumors

NCT04855656Advanced Solid Tumor

DrugsCamonsertib·Lunresertib

Debiopharm International SA

Phase 1

464

California, Connecticut, Florida, Massachusetts, Michigan, Minnesota, Missouri, New York

2021-04-30

Recruiting

Ventral or Inguinal Hernia, Robotically Repaired With OviTex Mesh

NCT04779918Hernia, Ventral, Hernia, Inguinal

Tela Bio Inc

Not applicable

160

Alabama, Colorado, Florida, Kansas, Kentucky, Michigan, New York, Texas

2021-04-29

Recruiting

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.

NCT04752774Spasticity

DrugsDysport·Corabotase

Ipsen

Phase 1/2

240

California, Kansas, Michigan, Pennsylvania, Texas

2021-04-29

Active, closed

A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI

NCT04825743ST-elevation Myocardial Infarction (STEMI)

CeleCor Therapeutics

Phase 3

2,463

Alaska, Michigan, Missouri, Texas

2021-04-24

Recruiting

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

NCT04775485Low-grade Glioma, Advanced Solid Tumor

DrugTovorafenib

Day One Biopharmaceuticals, Inc.

Phase 2

141

California, District of Columbia, Illinois, Maryland, Massachusetts, Michigan, Missouri, New York

2021-04-22

Recruiting

A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study

NCT04641247Ovarian Neoplasms, Breast Neoplasms

DrugNiraparib

GlaxoSmithKline

Phase 2

Arizona, California, Florida, Georgia, Illinois, Massachusetts, Michigan, New Jersey

2021-04-16

Recruiting

Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia

NCT04159103Propionic Acidemia

DrugMRNA-3927

ModernaTX, Inc.

Phase 1/2

California, Florida, Illinois, Maryland, Massachusetts, Michigan, New York, North Carolina

2021-04-15

Active, closed

Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1

NCT04954001Neurofibromatosis 1, Plexiform Neurofibroma, NF1

DrugLuvometinib

Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.

Phase 1/2

160

California, Florida, Michigan, South Carolina

2021-03-26

Active, closed

A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)

NCT04817007Myelofibrosis

DrugsBMS-986158·Fedratinib·Ruxolitinib

Bristol-Myers Squibb

Phase 1/2

216

California, Florida, Louisiana, Massachusetts, Michigan, New Jersey, North Carolina, Pennsylvania

2021-03-22

Active, closed

Validation of Genomic Immune-phenotyping Profiles to Predict Risk of Kidney Transplant Rejection

NCT04727788Kidney Transplant Rejection

Verici Dx

Observational

550

Illinois, Maryland, Michigan, Nebraska, Ohio, Pennsylvania, Tennessee, Washington

2021-03-21

Active, closed

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined With Abiraterone Acetate and Prednisone (AA-P) Versus Placebo Combined With AA-P as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer

NCT04691804Metastatic Castration-Resistant Prostate Cancer (mCRPC)

DrugFluzoparib

Jiangsu HengRui Medicine Co., Ltd.

Phase 3

496

Alaska, Arizona, California, Florida, Louisiana, Maryland, Michigan, Nebraska

2021-03-18

Active, closed

REgiStry Of the NAtural History of recurreNt periCarditis in pEdiatric and Adult Patients

NCT04687358Recurrent Pericarditis

Kiniksa Pharmaceuticals International, plc

Observational

500

Alaska, Arizona, California, Illinois, Iowa, Maryland, Massachusetts, Michigan

2021-03-16

Active, closed

Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease

NCT04639050Alzheimers Disease

DrugTrontinemab

Hoffmann-La Roche

Phase 1/2

241

Florida, Georgia, Michigan, Pennsylvania, Texas

2021-03-15

Active, closed

Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis

NCT04562389Myelofibrosis

DrugsSelinexor·Ruxolitinib

Karyopharm Therapeutics Inc

Phase 3

353

Alabama, California, Colorado, Connecticut, District of Columbia, Kentucky, Maryland, Michigan

2021-03-11

Recruiting

Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC

NCT04686305Locally Advanced or Metastatic Non-Small Cell Lung Cancer

DrugsVolrustomig·Rilvegostomig·Trastuzumab deruxtecan·Durvalumab

AstraZeneca

Phase 1

304

California, Kansas, Maryland, Michigan, New York, Texas, Virginia, Washington

2021-03-09

Recruiting

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

NCT04777994Advanced Solid Tumor Cancer

Calico Life Sciences LLC

Phase 1

248

Arizona, Connecticut, Maryland, Massachusetts, Michigan, New York, North Carolina, Pennsylvania

2021-03-09

Active, closed

TH1902 in Patients With Advanced Solid Tumors

NCT04706962Solid Tumor, TNBC - Triple-Negative Breast Cancer, Hormone Receptor-positive Breast Cancer, Epithelial Ovarian Cancer

Theratechnologies

Phase 1

Michigan, Pennsylvania, Texas

2021-03-04

Active, closed

An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions

NCT04717414Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis

DrugLuspatercept

Celgene

Phase 3

313

California, Florida, Illinois, Kentucky, Michigan, Missouri, New Jersey, New York

2021-02-25

Active, closed

Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcinoma

NCT04696731Advanced/Metastatic Clear Cell Renal Cell Carcinoma

DrugsALLO-647·Fludarabine·Cyclophosphamide

Allogene Therapeutics

Phase 1

120

California, Connecticut, District of Columbia, Florida, Michigan, New York, Oregon, Texas

2021-02-24

Active, closed

Study of AZD2811 + Durvalumab in ES-SCLC

NCT04745689Small-Cell Lung Cancer

DrugsEtoposide·Durvalumab·Cisplatin·Carboplatin

AstraZeneca

Phase 2

Michigan

2021-02-23

Active, closed

Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A

NCT04644575Hemophilia A

DrugEfanesoctocog alfa

Bioverativ, a Sanofi company

Phase 3

261

California, Florida, Georgia, Illinois, Iowa, Michigan, Nevada, New York

2021-02-23

Recruiting

Qudexy XR for the Prevention of Migraine in Children 6 to 11 Years Old

NCT04748601Migraine Disorders

Upsher-Smith Laboratories

Phase 4

132

Alabama, California, Colorado, Connecticut, Florida, Michigan, Mississippi, Missouri

2021-02-19

Active, closed

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Emicizumab in Participants From Birth to 12 Months of Age With Hemophilia A Without Inhibitors

NCT04431726Severe Hemophilia A

DrugEmicizumab

Hoffmann-La Roche

Phase 3

Arizona, California, Colorado, Louisiana, Michigan, Washington

2021-02-04

Active, closed

Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation

NCT04755283Atrial Fibrillation (AF), Stroke

DrugsAbelacimab·Rivaroxaban

Anthos Therapeutics, Inc.

Phase 2

1,287

Alabama, Connecticut, Florida, Georgia, Kentucky, Maryland, Massachusetts, Michigan

2021-02-02

Recruiting

A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT04634552Hematological Malignancies

DrugTalquetamab

Janssen Research & Development, LLC

Phase 2

510

Alabama, Arkansas, California, Florida, Georgia, Illinois, Kentucky, Michigan

2021-02-01

Active, closed

The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy

NCT04572633Liver Neoplasms, Hepatocellular Carcinoma, Liver Metastases

HistoSonics, Inc.

Not applicable

Florida, Illinois, Kansas, Michigan, Wisconsin

2021-01-27

Recruiting

Isatuximab in Combination With Novel Agents in RRMM - Master Protocol

NCT04643002Plasma Cell Myeloma Refractory

DrugsEvorpacept·Belumosudil·Belantamab mafodotin·Isatuximab

Sanofi

Phase 1/2

258

Georgia, Illinois, Michigan, New York, Ohio

2021-01-25

Active, closed

Comparing UroLift Experience Against Rezūm

NCT04338776Benign Prostatic Hyperplasia

NeoTract, Inc.

Not applicable

120

California, Michigan, New York, Texas

2021-01-22

Active, closed

An Open-Label Extension Study of STK-001 for Patients With Dravet Syndrome

NCT04740476Dravet Syndrome

DrugZorevunersen

Stoke Therapeutics, Inc

Phase 2

California, Colorado, District of Columbia, Florida, Illinois, Iowa, Massachusetts, Michigan

2021-01-20

Active, closed

Trial of ERapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance

NCT04230499Familial Adenomatous Polyposis

DrugERapa

Rapamycin Holdings Inc.

Phase 2

Michigan, Ohio, Texas

2021-01-18

Active, closed

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

NCT04589845Solid Tumors

DrugsCamonsertib·Belvarafenib·Pralsetinib·Divarasib

Hoffmann-La Roche

Phase 2

920

Arizona, California, Georgia, Idaho, Illinois, Indiana, Maryland, Michigan

2021-01-18

Active, closed

A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)

NCT04628494Diffuse Large B-cell Lymphoma

DrugEpcoritamab

Genmab

Phase 3

483

Indiana, Kentucky, Michigan, Minnesota, New Jersey, North Carolina, Ohio, Texas

2021-01-13

Active, closed

A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL

NCT04521231B Cell Precursor Acute Lymphoblastic Leukemia

DrugBlinatumomab

Amgen

Phase 1/2

181

California, Illinois, Maryland, Michigan, New York, Pennsylvania, Tennessee, Texas

2021-01-04

Recruiting

Secukinumab Open Label Roll-over Extension Protocol

NCT04638647Autoimmunity, Inflammation

DrugSecukinumab

Novartis Pharmaceuticals

Phase 4

1,000

California, Colorado, Florida, Illinois, Indiana, Maryland, Michigan, Nebraska

2020-12-22

Active, closed

A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers

NCT04626635Advanced Solid Tumors

DrugsMarlotamig·Trifluridine/Tipiracil·Cemiplimab·Bevacizumab

Regeneron Pharmaceuticals

Phase 1/2

548

California, Colorado, Florida, Illinois, Iowa, Michigan, New Jersey, New York

2020-12-21

Active, closed

Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules

NCT04171492Nodule Solitary Pulmonary, Non-small Cell Carcinoma

Biodesix, Inc.

Observational

2,000

Colorado, Connecticut, District of Columbia, Indiana, Maryland, Michigan, Minnesota, Missouri

2020-12-18

Active, closed

A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy

NCT04640623Urinary Bladder Neoplasms

DrugsTAR-200·Cetrelimab

Janssen Research & Development, LLC

Phase 2

220

Arizona, California, Colorado, Illinois, Indiana, Kansas, Michigan, New York

2020-12-18

Recruiting

Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

NCT04592445Heart Failure With Preserved Ejection Fraction (HFpEF

Axon Therapies, Inc.

Not applicable

150

Alabama, Arizona, California, Georgia, Illinois, Indiana, Louisiana, Michigan

2020-12-18

Active, closed

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

NCT04663308Primary Sclerosing Cholangitis

DrugVolixibat

Mirum Pharmaceuticals, Inc.

Phase 2

182

California, Colorado, District of Columbia, Florida, Massachusetts, Michigan, Minnesota, Mississippi

2020-12-18

Active, closed

Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia

NCT04490915Congenital Adrenal Hyperplasia

DrugCrinecerfont

Neurocrine Biosciences

Phase 3

182

California, Colorado, Georgia, Indiana, Maryland, Massachusetts, Michigan, Minnesota

2020-12-16

Active, closed

Beating Heart Mitral Valve Repair With the HARPOON™ System

NCT04375332Mitral Regurgitation

Edwards Lifesciences

Not applicable

California, Georgia, Maryland, Michigan, Minnesota, Oregon, Tennessee, Utah

2020-12-16

Recruiting

Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities

NCT04683250RET-altered Non Small Cell Lung Cancer, RET-altered Solid Tumors

Taiho Pharmaceutical Co., Ltd.

Phase 1/2

244

California, Massachusetts, Michigan, New York, Tennessee, Texas

2020-12-16

Active, closed

A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001)

NCT04471727Small-Cell Lung Cancer, Neuroendocrine Carcinoma

DrugsGocatamig·Ifinatamab Deruxtecan·Atezolizumab

Harpoon Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 1/2

232

California, Colorado, Massachusetts, Michigan, New York, Ohio, Oregon, Tennessee

2020-12-14

Recruiting

A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

NCT04590326Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Endometrial Cancer

DrugsUbamatamab·Sarilumab·Cemiplimab

Regeneron Pharmaceuticals

Phase 1/2

612

California, Florida, Illinois, Massachusetts, Michigan, New York, Ohio, Pennsylvania

2020-12-08

Active, closed

A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder

NCT04658862Urinary Bladder Neoplasms

DrugsTAR-200·Cetrelimab·Gemcitabine·Cisplatin

Janssen Research & Development, LLC

Phase 3

518

California, Colorado, Florida, Georgia, Illinois, Michigan, Nebraska, New Jersey

2020-12-07

Active, closed

Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene

NCT04794101X-Linked Retinitis Pigmentosa

MeiraGTx Ocular UK Ltd

Phase 3

California, Florida, Georgia, Massachusetts, Michigan, North Carolina, Pennsylvania, Texas

2020-12-04

Active, closed

Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome

NCT04623541Relapsed/Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Richter's Syndrome, Treatment-naïve High Risk Chronic Lymphocytic Leukemia

DrugsEpcoritamab·Pirtobrutinib·Lenalidomide·Venetoclax

Genmab

Phase 1/2

194

Alabama, California, Florida, Maryland, Massachusetts, Michigan, New Jersey, New York

2020-11-25

Active, closed

IN.PACT™ AV Access Post-Approval Study (PAS002)

NCT04543539Arteriovenous Fistula, Arteriovenous Fistula Stenosis, Arteriovenous Fistula Occlusion, Fistula

Medtronic

Observational

240

California, Connecticut, District of Columbia, Florida, Iowa, Michigan, Minnesota, New Jersey

2020-11-13

Active, closed

A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer

NCT04557059Prostatic Neoplasms

DrugsLhrha·Apalutamide

Janssen Pharmaceutica N.V., Belgium

Phase 3

691

Arizona, Arkansas, Colorado, Florida, Indiana, Michigan, New York, Ohio

2020-11-12

Recruiting

A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

NCT04302025Non-small Cell Lung Cancer

DrugsCobimetinib·Pralsetinib·Divarasib·SBRT

Genentech, Inc.

Phase 2

California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Massachusetts, Michigan

2020-11-06

Active, closed

Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs

NCT04301518Preterm Labor, Preterm Birth

Sera Prognostics, Inc.

Not applicable

6,500

California, Connecticut, Delaware, Florida, Kentucky, Louisiana, Massachusetts, Michigan

2020-11-06

Active, closed

Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)

NCT04663347Diffuse Large B-Cell Lymphoma, Follicular Lymphoma

DrugsR-Ice·Rituximab and lenalidomide·Gemcitabine and oxaliplatin·Epcoritamab

Genmab

Phase 1/2

543

Alabama, California, Massachusetts, Michigan, New Jersey, New York, North Carolina, Texas

2020-11-03

Active, closed

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)

NCT04512235AL Amyloidosis

DrugsAnselamimab·Cyclophosphamide, bortezomib, and dexamethasone (CyBorD)

Alexion Pharmaceuticals, Inc.

Phase 3

281

Arizona, California, Florida, Indiana, Louisiana, Maryland, Massachusetts, Michigan

2020-11-03

Active, closed

The Smart Pump Study

NCT04465201Cardiac Output

Abiomed Inc.

Not applicable

Louisiana, Massachusetts, Michigan, New York

2020-11-02

Active, closed

The Synergy Disc To Anterior Cervical Discectomy and Fusion

NCT04469231Cervical Degenerative Disc Disease

Synergy Spine Solutions

Not applicable

175

Arizona, California, Colorado, Florida, Indiana, Michigan, New York, North Carolina

2020-10-30

Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NCT04585750Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor

DrugsRezatapopt·Keytruda·Pembrolizumab

PMV Pharmaceuticals, Inc

Phase 1/2

300

California, Colorado, Connecticut, Delaware, Florida, Massachusetts, Michigan, New York

2020-10-29

Recruiting

The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

NCT04494295Supratentorial Hemorrhage

Integra LifeSciences Corporation

Observational

500

California, Florida, Illinois, Maryland, Michigan, Missouri, New Jersey, New York

2020-10-23

Active, closed

Claudin18.2 CAR-T (CT041) in Patients With Gastric, Pancreatic Cancer, or Other Specified Digestive Cancers

NCT04404595Gastric Cancer, Pancreatic Cancer

CARsgen Therapeutics Co., Ltd.

Phase 1/2

110

California, Florida, Kansas, Michigan, Minnesota, New York, Ohio, Texas

2020-10-23

Active, closed

TTVR Early Feasibility Study

NCT04433065Tricuspid Regurgitation

Medtronic Cardiovascular

Not applicable

150

Alabama, Arizona, California, Connecticut, Georgia, Michigan, Minnesota, Montana

2020-10-20

Active, closed

A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions

NCT04538664Carcinoma, Non-Small-Cell Lung

DrugsAmivantamab·Pemetrexed·Carboplatin

Janssen Research & Development, LLC

Phase 3

308

California, District of Columbia, Florida, Georgia, Michigan, Missouri, New Jersey, New York

2020-10-13

Active, closed

Impella ECP Early Feasibility Study

NCT04477603High-risk Percutaneous Coronary Intervention

Abiomed Inc.

Not applicable

100

Massachusetts, Michigan, New Jersey, Ohio

2020-10-09

Active, closed

Study to Evaluate D-1553 in Subjects With Solid Tumors

NCT04585035Solid Tumor, Adult, NSCLC, CRC

DrugD-1553

InventisBio Co., Ltd

Phase 1/2

180

California, Kentucky, Michigan, New York, Oregon

2020-10-02

Active, closed

Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer

NCT04590963Squamous Cell Carcinoma of the Head and Neck

DrugsMonalizumab·Erbitux·Cetuximab

AstraZeneca

Phase 3

370

Arizona, Illinois, Kansas, Massachusetts, Michigan, Minnesota, Missouri, Nevada

2020-10-02

By invitation

Lumbar Interbody Implant Study

NCT04418830Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Scoliosis, Spinal Stenosis

NuVasive

Observational

1,050

California, Connecticut, Florida, Illinois, Michigan, Missouri, North Carolina, Ohio

2020-10-01

Active, closed

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT04487080Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab·Osimertinib

Janssen Research & Development, LLC

Phase 3

1,074

Arizona, California, Colorado, Florida, Georgia, Louisiana, Maryland, Michigan

2020-09-30

Active, closed

Less Frequent IV Dosing & Tumor Microenvironment (TME) Study of Nemvaleukin Alfa (ALKS 4230) Monotherapy and in Combination With Pembrolizumab (ARTISTRY-3)

NCT04592653Advanced Solid Tumor

DrugsKeytruda·Pembrolizumab

Mural Oncology, Inc

Phase 1/2

Michigan, Texas, Utah, Virginia

2020-09-30

Active, closed

Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors

NCT04557449Liposarcoma, Prostate Cancer, Breast Neoplasms, Adenocarcinoma of Lung

DrugsAtirmociclib·Midazolam

Pfizer

Phase 2

362

California, Connecticut, Massachusetts, Michigan, Tennessee, Texas

2020-09-23

Active, closed

A Study of Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT04557098Hematological Malignancies

DrugTeclistamab

Janssen Research & Development, LLC

Phase 2

194

Alabama, California, Georgia, Michigan, New York, North Carolina, Pennsylvania

2020-09-17

Recruiting

Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3)

NCT04098744CIN 2/3, HPV Infection, Pre-Cancerous Dysplasia, Cervical Dysplasia

DrugArtesunate

Frantz Viral Therapeutics, LLC

Phase 2

Florida, Michigan, Ohio, Texas

2020-09-09

Active, closed

A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors

NCT05593094Advanced Solid Tumors, HER2-positive Breast Cancer

DrugZN-A-1041

Hoffmann-La Roche

Phase 1/2

210

Arizona, California, Massachusetts, Michigan, North Carolina, Texas

2020-09-03

Recruiting

Hydrus® Microstent New Enrollment Post-Approval Study

NCT04553523Primary Open Angle Glaucoma

Alcon Research

Not applicable

545

California, Colorado, Iowa, Kansas, Maryland, Michigan, Minnesota, Missouri

2020-08-25

Active, closed

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)

NCT04504825AL Amyloidosis

DrugsAnselamimab·Cyclophosphamide, bortezomib, and dexamethasone (CyBorD)

Alexion Pharmaceuticals, Inc.

Phase 3

125

California, Florida, Indiana, Louisiana, Massachusetts, Michigan, Minnesota, Missouri

2020-08-25

Active, closed

Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

NCT04404283Diffuse Large B-cell Lymphoma

DrugsBrentuximab Vedotin·Lenalidomide·Rituximab

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

239

Alabama, California, Florida, Kansas, Maryland, Michigan, Missouri, Ohio

2020-08-20

Recruiting

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)

NCT04419649Myelodysplastic Syndromes, Cytopenia

DrugElritercept

Takeda

Phase 2

160

Arkansas, California, Florida, Maryland, Michigan, New Jersey, New York, Pennsylvania

2020-08-19

Active, closed

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Participants With Follicular Lymphoma

NCT04246086Follicular Lymphoma

DrugsMosunetuzumab·Tocilizumab·Lenalidomide

Hoffmann-La Roche

Phase 1/2

237

California, Florida, Kentucky, Louisiana, Michigan, North Carolina, Ohio, Rhode Island

2020-08-12

Active, closed

A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies

NCT04227847Myelodysplastic Syndrome, Acute Myeloid Leukemia

DrugsVenclexta·Azacitidine·Venetoclax

Seagen, a wholly owned subsidiary of Pfizer

Phase 1

170

Alabama, California, Colorado, Kansas, Kentucky, Massachusetts, Michigan, Missouri

2020-08-07

Active, closed

Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib

NCT04421963Ovarian Cancer, Breast Cancer

DrugOlaparib

AstraZeneca

Phase 3

185

Florida, Maryland, Michigan, Minnesota, New Jersey, New York, Pennsylvania, Rhode Island

2020-08-04

Active, closed

A Phase III Study to Evaluate the Efficacy and Safety of Benralizumab in Patients With Hypereosinophilic Syndrome (HES)

NCT04191304Hypereosinophilic Syndrome

DrugBenralizumab

AstraZeneca

Phase 3

134

California, Georgia, Maryland, Michigan, North Carolina, Ohio, Utah

2020-07-20

Active, closed

Linerixibat Long-term Safety, and Tolerability Study

NCT04167358Cholestasis

GlaxoSmithKline

Phase 3

242

California, Florida, Michigan, New York, North Carolina, Pennsylvania, Texas, Washington

2020-07-14

Active, closed

Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency

NCT04493853Hormone-Sensitive Prostate Cancer

DrugsZytiga·Capivasertib·Abiraterone acetate

AstraZeneca

Phase 3

1,012

Arizona, California, Colorado, Connecticut, Florida, Illinois, Maryland, Michigan

2020-07-13

Active, closed

RETHINK REFLUX Registry

NCT04253392Gastroesophageal Reflux

Ethicon Endo-Surgery

Observational

500

Alabama, Arizona, California, Colorado, Florida, Illinois, Kentucky, Michigan

2020-07-08

Active, closed

Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)

NCT04380636Lung Neoplasms, Carcinoma, Non-Small-Cell Lung

DrugsParaplatin·Taxol·Olaparib·Etoposide

Merck Sharp & Dohme LLC

Phase 3

870

Alabama, Arkansas, California, Florida, Indiana, Kentucky, Massachusetts, Michigan

2020-07-06

Active, closed

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

NCT04478279Glioblastoma, Melanoma Stage IV, Breast Cancer, Prostate Cancer

DrugTemozolomide

Sapience Therapeutics

Phase 1/2

125

California, Colorado, Illinois, Michigan, New York, North Carolina, Tennessee

2020-07-01

Recruiting

Efficacy and Safety of the CG-100 Intraluminal Bypass Device

NCT04184973Rectal Cancer, Rectal Tumor, Rectal/Anal

Colospan Ltd.

Not applicable

250

California, Colorado, Michigan, Rhode Island, Utah

2020-06-23

Active, closed

Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC

NCT04295811Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia

Lucid Diagnostics, Inc.

Not applicable

784

Colorado, District of Columbia, Florida, Illinois, Louisiana, Maryland, Massachusetts, Michigan

2020-06-18

Active, closed

A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.

NCT04224493Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma

DrugTazemetostat

Epizyme, Inc.

Phase 3

599

Alabama, Arizona, California, Colorado, Florida, Illinois, Michigan, Minnesota

2020-06-11

Active, closed

4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP)

NCT04517149X-Linked Retinitis Pigmentosa

4D Molecular Therapeutics

Phase 1/2

Colorado, Florida, Michigan, New York, North Carolina, Oregon, Texas, Utah

2020-06-09

Active, closed

Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat in Participants With RRMM

NCT07084896Multiple Myeloma

DrugsNirogacestat·Belantamab mafodotin

GlaxoSmithKline

Phase 1/2

106

Georgia, Massachusetts, Michigan, Wisconsin

2020-06-08

Active, closed

The JenaValve ALIGN-AR Pivotal Trial

NCT04415047Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency, Aortic Valve Disease

JenaValve Technology, Inc.

Not applicable

180

Arizona, California, District of Columbia, Florida, Georgia, Illinois, Maryland, Michigan

2020-05-22

Active, closed

2019-06 TRISCEND Study

NCT04221490Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases

Edwards Lifesciences

Not applicable

228

California, Georgia, Illinois, Massachusetts, Michigan, New York, Oregon, Pennsylvania

2020-05-06

Active, closed

Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

NCT04162210Multiple Myeloma

DrugsBelantamab mafodotin·Dexamethasone

GlaxoSmithKline

Phase 3

325

Arizona, Colorado, Michigan, Nebraska, New York, Ohio, Oregon, Texas

2020-04-02

Active, closed

Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD

NCT04229017Degenerative Disc Disease

Providence Medical Technology, Inc.

Not applicable

236

Arizona, California, Colorado, Illinois, Kentucky, Louisiana, Maryland, Michigan

2020-03-18

Active, closed

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

NCT04152499Epithelial Ovarian Cancer, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Urothelial Carcinoma

DrugSacituzumab tirumotecan

Klus Pharma Inc.

Phase 1/2

1,410

California, Florida, Michigan, Oklahoma, Oregon, Texas, Virginia

2020-02-28

Active, closed

FemBloc® Permanent Contraception - Confirmation Feasibility Trial

NCT04273594Contraception

Femasys Inc.

Not applicable

Arizona, Georgia, Indiana, Michigan, Ohio

2020-02-27

By invitation

Global Utilization And Registry Database for Improved heArt preservatioN

NCT04141605Heart Diseases, Heart Failure, Heart Defects, Congenital

Paragonix Technologies

Observational

3,000

California, District of Columbia, Florida, Indiana, Kansas, Massachusetts, Michigan, New York

2020-02-14

Active, closed

A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

NCT04211337Medullary Thyroid Cancer

DrugsVandetanib·Selpercatinib·Cabozantinib

Loxo Oncology, Inc.

Phase 3

291

Alabama, California, Georgia, Illinois, Massachusetts, Michigan, New York, Ohio

2020-02-11

Active, closed

Long-term Follow-up Study of Patients Receiving Onasemnogene Abeparvovec-xioi

NCT04042025Spinal Muscular Atrophy Type I, Spinal Muscular Atrophy Type II, Spinal Muscular Atrophy Type III, SMA

DrugsOnasemnogene Abeparvovec-xioi·Zolgensma

Novartis Gene Therapies

Phase 3

California, Colorado, Illinois, Maryland, Massachusetts, Michigan, Missouri, New York

2020-02-10

Active, closed

Post Market Clinical Follow-Up Study for EVOLUTION® BIOFOAM® Tibia and EVOLUTION® CS/CR Porous Femur

NCT04301622Knee Osteoarthritis, Traumatic Arthritis of Knee, Avascular Necrosis, Degenerative Joint Disease of Knee

MicroPort Orthopedics Inc.

Observational

150

Michigan

2020-02-03

By invitation

A Study to Evaluate the Safety of Exposure to Wegovy During Pregnancy

NCT05503927Pregnancy, Obesity, Overweight

Novo Nordisk A/S

Observational

2,701

Michigan, New Jersey

2020-02-01

Active, closed

A 5-year Superion™ IDS Clinical Outcomes Post-Approval Evaluation (SCOPE)

NCT04192591Lumbar Spinal Stenosis

Boston Scientific Corporation

Not applicable

166

California, Florida, Georgia, Idaho, Illinois, Kansas, Massachusetts, Michigan

2020-01-30

Active, closed

A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

NCT04175600Hypertension, Pulmonary

DrugSelexipag

Actelion

Phase 3

138

Arizona, California, Colorado, District of Columbia, Florida, Indiana, Michigan, Ohio

2020-01-16

Active, closed

A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib

NCT04170283B-cell Malignancies

DrugsZanubrutinib·Tislelizumab

BeOne Medicines

Phase 3

955

Arizona, Arkansas, Colorado, Florida, Massachusetts, Michigan, Minnesota, Mississippi

2020-01-16

Recruiting

Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System

NCT04065438Focal Segmental Glomerulosclerosis

Kaneka Medical America LLC

Not applicable

California, Delaware, Michigan, New York, North Carolina, Ohio, South Carolina, Virginia

2020-01-01

Active, closed

Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Solid Tumors

NCT03967223Neoplasms

DrugsFludarabine·Cyclophosphamide

USWM CT, LLC

Phase 2

103

California, Colorado, Florida, Illinois, Iowa, Massachusetts, Michigan, Minnesota

2019-12-31

Active, closed

Cusatuzumab in Combination With Background Therapy for the Treatment of Participants With Acute Myeloid Leukemia

NCT04150887Leukemia, Myeloid, Acute

DrugsCusatuzumab·Venclexta·Azacitidine·Venetoclax

OncoVerity, Inc.

Phase 1

California, Kentucky, Michigan, New York, Pennsylvania, Texas, Vermont, Wisconsin

2019-12-23

Active, closed

Open-Label Extension: Tolerability and Effects of ALK-001 on Stargardt Disease (TEASE)

NCT04239625Stargardt Disease, Stargardt Macular Degeneration, Stargardt Macular Dystrophy, Autosomal Recessive Stargardt Disease 1 (ABCA4-related)

DrugALK-001

Alkeus Pharmaceuticals, Inc.

Phase 2

200

Arizona, California, Colorado, Florida, Indiana, Michigan, New York, Washington

2019-12-20

Recruiting

Terumo Aortic Global Endovascular Registry

NCT04246463Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery

Vascutek Ltd.

Observational

1,000

California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Indiana, Michigan

2019-12-17

By invitation

MDR - Comprehensive Primary/Micro Stem & Versa-Dial Ti Humeral Head

NCT04003311Shoulder Pain, Shoulder Injuries, Shoulder Fractures, Shoulder Disease

Zimmer Biomet

Observational

146

Idaho, Michigan, New York, Vermont

2019-12-13

Active, closed

Cold Agglutinin Disease Real World Evidence Registry

NCT05791708Cold Agglutinin Disease (CAD), Cold Agglutinin Syndrome (CAS)

RECORDATI GROUP

Observational

429

Alabama, California, District of Columbia, Georgia, Illinois, Iowa, Massachusetts, Michigan

2019-12-12

Recruiting

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

NCT04198766Solid Tumor, Non-Small Cell Lung Cancer, Head and Neck Cancer, Melanoma

DrugsCarboplatin (AUC 5)·Carboplatin (AUC 6)·Nab-paclitaxel·Pemetrexed

Inhibrx Biosciences, Inc

Phase 1/2

340

California, Florida, Georgia, Illinois, Iowa, Kentucky, Michigan, Minnesota

2019-12-10

Recruiting

Medtronic Cardiac Surgery PMCF Registry

NCT04073420Valve Disease, Heart

Medtronic Cardiac Surgery

Observational

2,700

Georgia, Michigan, New York, North Carolina, Ohio, Pennsylvania, Texas, Virginia

2019-12-02

Active, closed

Zephyr Valve Registry (ZEVR)

NCT04186546Emphysema

Pulmonx Corporation

Observational

150

Alabama, Illinois, Michigan, Pennsylvania, Texas, Virginia, Wisconsin

2019-11-25

Active, closed

Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With an Optimized Background Regimen (OBR) in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance

NCT04150068HIV-1-infection

DrugLenacapavir

Gilead Sciences

Phase 2/3

California, Connecticut, District of Columbia, Florida, Georgia, Illinois, Michigan, Missouri

2019-11-21

Active, closed

Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies

NCT04013685Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Myelodysplastic Syndromes, Acute Leukemia

DrugOrca-T

Orca Biosystems, Inc.

Phase 1

155

California, Colorado, Florida, Georgia, Illinois, Kansas, Massachusetts, Michigan

2019-11-21

Active, closed

An Extension Study of Ublituximab in Participants With Relapsing Multiple Sclerosis

NCT04130997Relapsing Multiple Sclerosis (RMS)

DrugUblituximab

TG Therapeutics, Inc.

Phase 3

1,100

California, Colorado, Florida, Illinois, Kansas, Michigan, Nevada, New Jersey

2019-11-18

Active, closed

NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)

NCT04148391Mild Cognitive Impairment, Mild Dementia, Parkinson Disease, Lewy Body Disease

Aptinyx

Phase 2

Arizona, California, Florida, Georgia, Michigan, Minnesota, New Jersey, New York

2019-11-14

Active, closed

Apple Hearing Study

NCT04172766Hearing Loss, Noise-Induced, Hearing Loss, Tinnitus

Apple Inc.

Observational

300,000

Michigan

2019-11-14

Active, closed

Phase 1/1b/2 Study of Oral PMD-026 in Patients With Metastatic Breast Cancer

NCT04115306Metastatic Breast Cancer

DrugFulvestrant

Phoenix Molecular Designs

Phase 1/2

Arizona, California, Florida, Illinois, Massachusetts, Michigan, Ohio, Texas

2019-11-14

Active, closed

Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia Without Inhibitors

NCT04082429Haemophilia A Without Inhibitors, Haemophilia B Without Inhibitors

DrugConcizumab

Novo Nordisk A/S

Phase 3

156

California, Georgia, Indiana, Iowa, Michigan, North Carolina, Pennsylvania, Tennessee

2019-11-13

Active, closed

A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm

NCT04041050Myeloproliferative Neoplasm

DrugsNavitoclax·Celebrex·Celecoxib·Ruxolitinib

AbbVie

Phase 1

California, Illinois, Kentucky, Michigan, Nebraska, North Carolina, Ohio, Pennsylvania

2019-11-08

Active, closed

Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression

NCT04180371Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer, Ovarian Cancer, Non-small Cell Lung Cancer

DrugsNuzefatide pevedotin·Opdivo·Nivolumab

BicycleTx Limited

Phase 1/2

288

California, Colorado, Florida, Michigan, Nevada, New York, Oklahoma, Pennsylvania

2019-11-07

Active, closed

IMGN632 as Monotherapy or With Venetoclax and/or Azacitidine for Participants With CD123-Positive Acute Myeloid Leukemia

NCT04086264Acute Myeloid Leukemia

DrugsIMGN632·Venclyxto·Decitabine·Venclexta

AbbVie

Phase 1/2

218

California, Florida, Illinois, Massachusetts, Michigan, Minnesota, New York, North Carolina

2019-11-06

Active, closed

A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer

NCT04025879Carcinoma, Non-Small-Cell Lung

DrugsOpdivo·Pemetrexed·Docetaxel·Nivolumab

Bristol-Myers Squibb

Phase 3

461

Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan, New Hampshire, Ohio

2019-11-05

Recruiting

Study of Ifinatamab Deruxtecan (DS-7300a, I-DXd) in Participants With Advanced Solid Malignant Tumors

NCT04145622Advanced Solid Tumor, Malignant Solid Tumor

DrugIfinatamab Deruxtecan

Daiichi Sankyo

Phase 1/2

250

California, Colorado, Florida, Massachusetts, Michigan, Missouri, New Jersey, New York

2019-11-03

Active, closed

A Phase 1/2 Trial of CLN-081 in Patients With Non-Small Cell Lung Cancer

NCT04036682Non Small Cell Lung Cancer, EGFR Exon 20 Mutation

DrugZipalertinib

Cullinan Therapeutics Inc.

Phase 1/2

284

California, Florida, Massachusetts, Michigan, New Jersey, New York, Ohio, Oregon

2019-10-31

Active, closed

Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.

NCT04157348Eosinophilic Granulomatous Vasculitis

DrugsBenralizumab·Mepolizumab

AstraZeneca

Phase 3

140

Colorado, Michigan, Minnesota, New Mexico, New York, Pennsylvania, Texas, Washington

2019-10-29

Active, closed

Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry

NCT04076813Myocardial Infarction

Chiesi USA, Inc.

Observational

5,050

California, Delaware, Florida, Idaho, Maryland, Massachusetts, Michigan, Missouri

2019-10-16

Active, closed

Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics

NCT03953300Asthma

DrugBenralizumab

AstraZeneca

Phase 4

Alabama, California, Florida, Georgia, Indiana, Iowa, Kansas, Michigan

2019-10-08

Active, closed

Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

NCT04126200Multiple Myeloma

DrugsFeladilimab·Nirogacestat·Belantamab mafodotin·Isatuximab

GlaxoSmithKline

Phase 1/2

208

Georgia, Indiana, Massachusetts, Michigan, Wisconsin

2019-10-07

By invitation

A Study for Participants Who Participated in Prior Clinical Studies of ASTX727 (Standard Dose)

NCT04093570Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes

DrugDecitabine

Taiho Oncology, Inc.

Phase 2

332

California, Florida, Illinois, Maryland, Michigan, Minnesota, New Jersey, New York

2019-09-30

Active, closed

A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)

NCT03989414Multiple Myeloma

DrugsElotuzumab·Mezigdomide·Isatuximab·Carfilzomib

Celgene

Phase 1/2

424

Colorado, Florida, Georgia, Illinois, Massachusetts, Michigan, Minnesota, New Jersey

2019-09-30

Recruiting

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

NCT04104776Advanced Solid Tumor, Diffuse Large B Cell Lymphoma, Lymphoma, T-Cell, Mesothelioma, Malignant

DrugsTulmimetostat·Enzalutamide

Novartis Pharmaceuticals

Phase 1/2

300

Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan, New Jersey, New York

2019-09-18

Active, closed

Portico Next Generation Approval Study

NCT04011722Symptomatic Severe Aortic Stenosis

Abbott Medical Devices

Not applicable

333

California, District of Columbia, Illinois, Indiana, Kansas, Michigan, Minnesota, New Jersey

2019-09-17

Active, closed

COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC

NCT04068610Metastatic Microsatellite-stable Colorectal Cancer

DrugsOleclumab·Folfox·Durvalumab·Bevacizumab

MedImmune LLC

Phase 1/2

California, Michigan, Nevada, New York, Ohio, Rhode Island, Tennessee, Texas

2019-09-13

Active, closed

First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia

NCT04067336Advanced Malignant Neoplasm, Acute Myeloid Leukemia, Mixed Lineage Leukemia, Mixed Lineage Acute Leukemia

DrugsZiftomenib·Itraconazole·Midazolam

Kura Oncology, Inc.

Phase 1/2

263

Arizona, California, Florida, Illinois, Maryland, Massachusetts, Michigan, Minnesota

2019-09-12

Recruiting

The RESET System Pivotal Clinical Trial (Protocol Revision H)

NCT04101669Diabetes type2, Obesity

Morphic Medical Inc.

Not applicable

264

Arizona, District of Columbia, Florida, Massachusetts, Michigan, New York, Texas

2019-09-09

Recruiting

Active Surveillance SNEP Assay Registry Trial for Prostate Cancer

NCT04052048Prostate Cancer Aggressiveness

Immunis.AI

Observational

2,000

Michigan

2019-09-09

Active, closed

An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial

NCT03844048Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia, Multiple Myeloma, Non-Hodgkin's Lymphoma

DrugsVenclexta·Venetoclax

AbbVie

Phase 3

165

Arizona, California, Illinois, Massachusetts, Michigan, New Hampshire, Washington

2019-09-06

Active, closed

Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's Disease

NCT04120493Huntington's Disease

UniQure Biopharma B.V.

Phase 1/2

Alabama, Arizona, California, Colorado, Illinois, Maryland, Michigan, Ohio

2019-09-06

Active, closed

Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET

NCT03993873Advanced Solid Tumor, Metastatic Solid Tumors, MET Gene Alterations

Turning Point Therapeutics, Inc.

Phase 1

California, Colorado, Illinois, Massachusetts, Michigan, Missouri, Ohio, Texas

2019-09-05

Active, closed

A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer

NCT04077463Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab·Pemetrexed·Carboplatin

Janssen Research & Development, LLC

Phase 1

701

California, Florida, Massachusetts, Michigan, Missouri, New York, Oregon, Pennsylvania

2019-09-04

Active, closed

A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation

NCT04002297Mantle Cell Lymphoma; Non-Hodgkin Lymphoma

DrugsBendamustine·Zanubrutinib·Rituximab

BeOne Medicines

Phase 3

510

California, Illinois, Massachusetts, Michigan, Nevada, New York, Oregon, Pennsylvania

2019-08-20

Active, closed

Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia

NCT04119050Warm Autoimmune Hemolytic Anemia

DrugNipocalimab

Janssen Research & Development, LLC

Phase 2/3

118

California, Colorado, Florida, Illinois, Kansas, Louisiana, Michigan, Missouri

2019-08-15

Active, closed

Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

NCT04044768Synovial Sarcoma, Myxoid Liposarcoma

USWM CT, LLC

Phase 2

California, Colorado, Florida, Illinois, Maryland, Massachusetts, Michigan, Missouri

2019-08-13

Recruiting

A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors

NCT03972657Metastatic Castration-Resistant Prostate Cancer (mCRPC), Clear Cell Renal Cell Carcinoma (ccRCC)

DrugsNezastomig·Cemiplimab

Regeneron Pharmaceuticals

Phase 1/2

345

Arizona, California, Colorado, Connecticut, Florida, Massachusetts, Michigan, Minnesota

2019-08-12

Recruiting

A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials

NCT04064060Myelodysplastic Syndromes (MDS), Beta-thalassemia, Myeloproliferative Neoplasm(MPN)-Associated Myelofibrosis

DrugLuspatercept

Celgene

Phase 3

665

California, Florida, Illinois, Massachusetts, Michigan, New York, Ohio, Pennsylvania

2019-08-12

Active, closed

Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)

NCT03974022Non-Small Cell Lung Cancer

DrugSunvozertinib

Dizal Pharmaceuticals

Phase 1/2

315

California, Colorado, Florida, Massachusetts, Michigan, New York, Ohio, Virginia

2019-07-09

Recruiting

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

NCT03947385Metastatic Uveal Melanoma, Cutaneous Melanoma, Colorectal Cancer, Other Solid Tumors

DrugsDarovasertib·Binimetinib·Crizotinib

IDEAYA Biosciences

Phase 1/2

336

California, Colorado, Iowa, Michigan, New York, North Carolina, Ohio, Pennsylvania

2019-06-28

Active, closed

Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma

NCT03937219Renal Cell Carcinoma

DrugsCabozantinib·Yervoy·Ipilimumab·Opdivo

Exelixis

Phase 3

855

California, Florida, Georgia, Illinois, Maine, Maryland, Massachusetts, Michigan

2019-06-25

Active, closed

Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC

NCT03997123Triple Negative Breast Neoplasms

DrugsCapivasertib·Paclitaxel

AstraZeneca

Phase 3

923

California, Florida, Illinois, Kansas, Maryland, Michigan, New York, Ohio

2019-06-25

Active, closed

Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)

NCT03944772Non-Small Cell Lung Cancer

DrugsNecitumumab·Gefitinib·Savolitinib·Selpercatinib

AstraZeneca

Phase 2

247

California, Connecticut, Illinois, Maryland, Massachusetts, Michigan, New York, Oregon

2019-06-25

Active, closed

remedē System Therapy Study

NCT03884660Central Sleep Apnea

Respicardia, Inc.

Observational

225

Arizona, California, Colorado, Florida, Georgia, Illinois, Kentucky, Michigan

2019-06-18

Active, closed

Early Feasibility Study for the Foldax Tria Aortic Heart Valve

NCT03851068Aortic Valve Disease, Aortic Valve Stenosis

Foldax, Inc

Not applicable

Indiana, Kansas, Michigan, Ohio

2019-06-18

Recruiting

Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia

NCT03817502Schizophrenia

DrugCariprazine

Gedeon Richter Plc.

Phase 3

330

California, Georgia, Michigan, Mississippi, New York, Ohio, Texas

2019-06-06

Active, closed

A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsy

NCT04015141Pediatric Epileptic Syndrome, Partial-onset Seizures

DrugPerampanel

Eisai Inc.

Phase 2

100

California, Colorado, Florida, Georgia, Michigan, New Jersey, North Carolina, Ohio

2019-05-31

Active, closed

Effisayil™ ON: A Study to Test Long-term Treatment With Spesolimab in People With Generalized Pustular Psoriasis Who Took Part in a Previous Study

NCT03886246Generalized Pustular Psoriasis

DrugSpesolimab

LEO Pharma

Phase 2

131

Michigan, New York

2019-05-29

Active, closed

Evaluation of the Safety and Efficacy of TLD in Patients with COPD

NCT03639051COPD

Nuvaira, Inc.

Not applicable

464

Alabama, Arizona, California, Florida, Illinois, Kentucky, Massachusetts, Michigan

2019-05-23

Active, closed

Case-Control Study of the Glycotest™ HCC Panel vs AFP for the Detection of Early-stage Hepatocellular Carcinoma

NCT03878550Carcinoma, Hepatocellular, Cirrhosis, Liver

Glycotest, Inc.

Observational

766

California, Florida, Illinois, Maryland, Michigan, Minnesota, New York, Pennsylvania

2019-05-22

Active, closed

Autologous Adult Adipose-Derived Regenerative Cell Injection Into Chronic Partial-Thickness Rotator Cuff Tears

NCT03752827Rotator Cuff Tear, Rotator Cuff Tendinitis

InGeneron, Inc.

Not applicable

168

Arizona, California, Florida, Georgia, Louisiana, Michigan, North Dakota, South Dakota

2019-05-13

Active, closed

A Dose Escalation Study Evaluating CPI-818 in Relapsed/Refractory T-Cell Lymphoma

NCT03952078T-cell Lymphoma

DrugSoquelitinib

Corvus Pharmaceuticals, Inc.

Phase 1

151

California, Michigan, Missouri, New Jersey, Ohio, Pennsylvania

2019-05-03

Active, closed

Autologous Muscle Derived Cells Compared to Placebo for Urinary Sphincter Repair in Post-surgical Female Stress Incontinence

NCT03104517Stress Urinary Incontinence

DrugIltamiocel

Cook MyoSite

Phase 3

Arizona, California, District of Columbia, Kansas, Michigan, New Mexico, New York, North Carolina

2019-04-23

Recruiting

An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia

NCT03813407Hyperkalaemia

DrugPumitamig

AstraZeneca

Phase 3

140

Alabama, Georgia, Maryland, Michigan, Missouri, New Jersey, New York, North Carolina

2019-04-02

Active, closed

A Registry of Subjects With Primary Indeterminate Lesions or Choroidal Melanoma

NCT03941379Choroidal Melanoma, Indeterminate Lesions of Eye

Aura Biosciences

Observational

Arizona, California, Massachusetts, Michigan, Minnesota, New York, Oregon, Pennsylvania

2019-03-27

Active, closed

Avelumab Program Rollover Study

NCT03815643Solid Tumors

DrugAvelumab

EMD Serono Research & Development Institute, Inc.

Phase 3

205

Arizona, Arkansas, California, Connecticut, Florida, Georgia, Maryland, Michigan

2019-03-22

Active, closed

Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors

NCT03821935Advanced Solid Tumors Cancer

DrugsLivmoniplimab·Budigalimab

AbbVie

Phase 1

364

Arkansas, California, Connecticut, Florida, Indiana, Michigan, Missouri, Montana

2019-02-21

Recruiting

ProACT Post-Approval Study

NCT03767595Stress Urinary Incontinence

Uromedica

Not applicable

145

Colorado, Florida, Georgia, Kansas, Michigan, Minnesota

2019-02-19

Active, closed

AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment

NCT03732794Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation

AtriCure, Inc.

Not applicable

150

California, District of Columbia, Illinois, Indiana, Maryland, Michigan, Minnesota, Missouri

2019-01-30

By invitation

The Informed Genetics Annotated Patient Registry

NCT04419896Predisposition, Genetic

Medneon

Observational

10,000

California, Illinois, Michigan, Tennessee, Texas

2019-01-23

Recruiting

Phase 1/2 Study of Linvoseltamab in Adult Patients With Relapsed or Refractory Multiple Myeloma

NCT03761108Multiple Myeloma

DrugLinvoseltamab

Regeneron Pharmaceuticals

Phase 1/2

387

Florida, Georgia, Indiana, Kentucky, Michigan, New Jersey, New York, Ohio

2019-01-23

Active, closed

NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy

NCT03589339Radiotherapy, Immunotherapy, Microsatellite Instability-High Solid Malignant Tumour, Metastasis From Malignant Tumor of Liver

DrugsJNJ-90301900·Opdivo·Nivolumab·Keytruda

Nanobiotix

Phase 1

145

California, Florida, Georgia, Illinois, Maryland, Michigan, New Mexico, New York

2019-01-16

Active, closed

Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients

NCT03737643Advanced Ovarian Cancer

DrugsOlaparib·Durvalumab·Paclitaxel·Bevacizumab

AstraZeneca

Phase 3

1,407

California, Florida, Georgia, Illinois, Indiana, Maryland, Michigan, Missouri

2019-01-04

Active, closed

Stereotactic MRI-guided On-table Adaptive Radiation Therapy (SMART) for Locally Advanced Pancreatic Cancer

NCT03621644Pancreatic Cancer

Viewray Inc.

Not applicable

133

California, Florida, Massachusetts, Michigan, Missouri, New Hampshire, New York, Oregon

2019-01-01

Active, closed

A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer

NCT03742102Triple Negative Breast Neoplasms

DrugsOleclumab·Capivasertib·Dato-DXd·Trastuzumab deruxtecan

AstraZeneca

Phase 1/2

243

Arizona, Maryland, Massachusetts, Michigan, Missouri, Texas, Virginia

2018-12-21

Active, closed

A Study to Evaluate the Long-term Safety and Tolerability of Lucerastat in Adult Subjects With Fabry Disease

NCT03737214Fabry Disease

Idorsia Pharmaceuticals Ltd.

Phase 3

107

Alabama, California, Florida, Illinois, Iowa, Massachusetts, Michigan, Pennsylvania

2018-12-18

Active, closed

Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

NCT03742895Advanced Solid Neoplasms

DrugOlaparib

Merck Sharp & Dohme LLC

Phase 2

329

Arizona, California, Colorado, Georgia, Kentucky, Maryland, Massachusetts, Michigan

2018-12-12

Active, closed

OCS™ Lung TOP Registry For Donor Lungs for Transplantation

NCT03639025Lung Transplantation

TransMedics

Observational

458

Arizona, California, Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan

2018-12-10

Active, closed

Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC

NCT03562637Triple Negative Breast Cancer

OBI Pharma, Inc

Phase 3

575

California, Florida, Illinois, Maryland, Michigan, New Jersey, Pennsylvania, Texas

2018-12-05

Active, closed

A Global Study to Evaluate Transarterial Chemoembolization (TACE) in Combination With Durvalumab and Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma

NCT03778957Hepatocellular Carcinoma

DrugsAvastin·Durvalumab·Bevacizumab

AstraZeneca

Phase 3

724

California, District of Columbia, Florida, Hawaii, Illinois, Louisiana, Michigan, Minnesota

2018-11-30

Active, closed

OPTIMIZE Sirolimus-Eluting Coronary Stent Systems Pharmacokinetics (PK) Study

NCT03716102Acute Coronary Syndrome

Svelte Medical Systems, Inc.

Not applicable

Arizona, Michigan

2018-11-21

Recruiting

Medtronic Terminate AF Study

NCT03546374Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation

Medtronic Cardiac Surgery

Not applicable

160

California, Connecticut, Indiana, Massachusetts, Michigan, Missouri, Ohio, Pennsylvania

2018-11-15

Active, closed

Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study

NCT03635424Bicuspid Aortic Valve

Medtronic Cardiovascular

Not applicable

150

Arizona, California, Connecticut, Florida, Georgia, Iowa, Massachusetts, Michigan

2018-10-30

Active, closed

Long-Term Follow-Up Study for Subjects Treated With P-BCMA-101

NCT03741127Multiple Myeloma

Poseida Therapeutics, Inc.

Phase 1

100

California, Colorado, Illinois, Kansas, Maryland, Michigan, Pennsylvania, Tennessee

2018-10-29

Recruiting

A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee

NCT03588975Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee

Vericel Corporation

Phase 3

California, Louisiana, Maryland, Michigan, New York, Ohio, Pennsylvania, Texas

2018-10-24

Active, closed

A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.

NCT03539744Multiple Myeloma

DrugsPomalidomide·Venetoclax·Dexamethasone

AbbVie

Phase 3

265

Arizona, California, Colorado, Florida, Kentucky, Maryland, Massachusetts, Michigan

2018-10-22

Recruiting

Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

NCT03715933Ewing Sarcoma, Colorectal Adenocarcinoma

DrugsINBRX-109·Temozolomide·Fluorouracil·Leucovorin

Inhibrx Biosciences, Inc

Phase 1

411

Arizona, California, Colorado, Georgia, Illinois, Michigan, New York, Ohio

2018-10-08

Active, closed

A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)

NCT03634540Renal Cell Carcinoma (RCC), Clear Cell Renal Cell Carcinoma (ccRCC), Kidney Cancer, Renal Cancer

DrugsBelzutifan·Cabozantinib

Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 2

118

California, Florida, Massachusetts, Michigan, Tennessee, Texas, Washington

2018-09-27

Active, closed

A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma

NCT03671018B-cell Non-Hodgkin Lymphoma

DrugsMosunetuzumab·Polatuzumab Vedotin·Tocilizumab·Rituximab

Hoffmann-La Roche

Phase 1/2

422

Alabama, California, Colorado, Florida, Michigan, New York, North Carolina, Pennsylvania

2018-09-25

Active, closed

Study to Evaluate the Safety and Efficacy of BF-200 ALA (Ameluz®) and BF-RhodoLED® in the Treatment of Superficial Basal Cell Carcinoma (sBCC) With Photodynamic Therapy (PDT).

NCT03573401Superficial Basal Cell Carcinoma

Biofrontera Inc.

Phase 3

187

Arizona, California, Colorado, Florida, Indiana, Michigan, New Hampshire, New York

2018-09-25

Active, closed

Post-Market Study of Comprehensive Reverse Augmented Glenoid and Mini Humeral Tray in Total Shoulder Arthroplasty

NCT03726554Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects

Zimmer Biomet

Not applicable

Florida, Kentucky, Michigan, New York, Tennessee, Virginia

2018-08-28

Recruiting

A Study to Evaluate the Safety (Compared to Iron Sucrose), Efficacy and Pharmacokinetics of Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects With Chronic Kidney Disease (CKD)

NCT03619850Chronic Kidney Disease; Iron Deficiency Anemia

DrugsIron sucrose·Ferumoxytol

AMAG Pharmaceuticals, Inc.

Phase 3

129

Florida, Michigan, Missouri, New York, Ohio, West Virginia

2018-08-13

Recruiting

A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration

NCT03178149Age-Related Macular Degeneration

DrugsAcyclovir·TMP/SMX·Prograf·Trimethoprim-sulfamethoxazole

Astellas Institute for Regenerative Medicine

Phase 1

Arizona, California, Florida, Georgia, Illinois, Massachusetts, Michigan, Mississippi

2018-07-13

Active, closed

First-in-Human (FIH) Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma

NCT03625037DLBCL, High-grade B-cell Lymphoma (HGBCL), Primary Mediastinal Large B-cell Lymphoma (PMBCL), FL

DrugEpcoritamab

Genmab

Phase 1/2

666

Arizona, California, Colorado, Florida, Iowa, Louisiana, Michigan, Nebraska

2018-06-26

Active, closed

A Study of Runimotamab in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers

NCT03448042Solid Tumors

DrugsTocilizumab·Trastuzumab

Genentech, Inc.

Phase 1

123

Connecticut, Michigan, New York, Tennessee, Texas

2018-06-06

Active, closed

INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)

NCT03491683Glioblastoma

DrugsINO-9012·Cemiplimab·Temozolomide

Inovio Pharmaceuticals

Phase 1/2

California, Florida, Georgia, Massachusetts, Michigan, New Jersey, New York, North Carolina

2018-05-31

Active, closed

A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis

NCT03523858Progressive Multiple Sclerosis (PMS)

DrugOcrelizumab

Hoffmann-La Roche

Phase 3

927

California, Florida, Illinois, Massachusetts, Michigan, Missouri, New York, Ohio

2018-05-28

Active, closed

A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)

NCT03401788VHL - Von Hippel-Lindau Syndrome, VHL Gene Mutation, VHL Syndrome, VHL Gene Inactivation

DrugBelzutifan

Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 2

Maryland, Massachusetts, Michigan, Pennsylvania, Tennessee, Texas, Utah

2018-05-02

Recruiting

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

NCT03526835Advanced/Metastatic Solid Tumors, Colorectal Cancer, Gastric Cancer, Gastroesophageal-junction Cancer

DrugPetosemtamab

Merus B.V.

Phase 1/2

560

California, Colorado, Florida, Georgia, Massachusetts, Michigan, Missouri, New York

2018-05-02

Active, closed

A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors

NCT03530397Selected Advanced Solid Tumors

DrugsVolrustomig·Nab-paclitaxel·Pemetrexed·Paclitaxel

MedImmune LLC

Phase 1

400

Michigan, New York, North Carolina, Rhode Island, Tennessee, Virginia

2018-04-24

Active, closed

Pyruvate Kinase Deficiency Global Longitudinal Registry

NCT03481738Pyruvate Kinase Deficiency

Agios Pharmaceuticals, Inc.

Observational

500

Arizona, Arkansas, California, Georgia, Massachusetts, Michigan, North Carolina, Pennsylvania

2018-04-23

Active, closed

THE ALIGN-AR EFS TRIAL: JenaValve Pericardial TAVR Aortic Regurgitation Study

NCT02732704Aortic Regurgitation

JenaValve Technology, Inc.

Not applicable

100

California, District of Columbia, Georgia, Michigan, New York, Texas, Washington

2018-04-20

By invitation

Adoptive Cell Therapy Long-term Follow-up (LTFU) Study

NCT03391778Neoplasms

USWM CT, LLC

Phase 1

250

Georgia, Maryland, Michigan, Missouri, New York, North Carolina, Oregon, Pennsylvania

2018-04-09

Active, closed

Study of the Safety and Effectiveness of Motiva Implants®

NCT03579901Breast Implants

Motiva USA LLC

Not applicable

800

California, Colorado, Georgia, Illinois, Indiana, Kentucky, Louisiana, Michigan

2018-04-06

Active, closed

A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer

NCT03431350Prostatic Neoplasms, Castration-Resistant

DrugsCetrelimab·Abiraterone acetate·Niraparib·Prednisone

Janssen Research & Development, LLC

Phase 2

136

Arizona, Colorado, Florida, Indiana, Maryland, Michigan, New York, Pennsylvania

2018-03-02

Recruiting

Mucopolysaccharidosis VII Disease Monitoring Program

NCT03604835Mucopolysaccharidosis VII, MPS VII, MPS 7, Sly Syndrome

Ultragenyx Pharmaceutical Inc

Observational

California, District of Columbia, Illinois, Michigan, New York, Utah, Washington

2018-01-29

Active, closed

Study Evaluating Safety, Tolerability and Pharmacokinetics (PK) of Tarlatamab in Adults With Small Cell Lung Cancer (SCLC)

NCT03319940Small Cell Lung Carcinoma

DrugsTarlatamab·Pembrolizumab

Amgen

Phase 1

269

California, Connecticut, Florida, Georgia, Illinois, Louisiana, Maryland, Michigan

2017-12-26

By invitation

Patient Outcomes With Robotic-Assisted Total Knee Arthroplasty

NCT06203756Arthroplasties, Knee Replacement, Revision Arthroplasty

Corin

Not applicable

713

Arizona, Connecticut, Michigan, New York, Oklahoma, Wisconsin

2017-11-09

Active, closed

U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer

NCT03260491Non-Small Cell Lung Cancer (NSCLC)

DrugPatritumab deruxtecan

Daiichi Sankyo

Phase 1

312

California, Georgia, Massachusetts, Michigan, New York, Ohio, Pennsylvania, Tennessee

2017-10-30

Active, closed

Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma

NCT03298451Hepatocellular Carcinoma

DrugsSorafenib·Tremelimumab·Durvalumab

AstraZeneca

Phase 3

1,324

California, District of Columbia, Florida, Kansas, Maryland, Michigan, Minnesota, New York

2017-10-11

Active, closed

BioVentrix Revivent TC™ System Clinical Study

NCT02931240Ventricular Dysfunction, Left

BioVentrix

Not applicable

126

Arizona, California, Florida, Georgia, Illinois, Louisiana, Michigan, Minnesota

2017-08-29

Recruiting

Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)

NCT03016819Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma, Soft-Tissue Sarcoma

DrugsCatequentenib·Digoxin·Dacarbazine·Rosuvastatin

Advenchen Laboratories, LLC

Phase 3

325

Arizona, California, Colorado, Florida, Illinois, Michigan, Minnesota, Missouri

2017-08-15

Active, closed

JOURNEY II XR Safety and Effectiveness PMCF

NCT03136887Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee, Unilateral Post-Traumatic Osteoarthritis of Knee, Knee Osteoarthritis, Degenerative Arthritis Peripheral Joint

Smith & Nephew, Inc.

Observational

176

California, Florida, Illinois, Maryland, Michigan, Nevada, New Jersey, New York

2017-07-28

Active, closed

The Chocolate Touch Study

NCT02924857Peripheral Artery Disease (PAD), Ischemia, Intermittent Claudication

TriReme Medical, LLC

Not applicable

333

Florida, Georgia, Louisiana, Michigan, Mississippi, Missouri, New York, Ohio

2017-07-26

Active, closed

A Study of Infuse® Bone Graft With Mastergraft® Strip and Posterior Fixation for Posterolateral Fusion (PLF) Treatment of Multi-Level Degenerative Lumbosacral Spinal Conditions

NCT03118505Multi-Level Degenerative Lumbosacral Spinal Conditions

Medtronic Spinal and Biologics

Not applicable

100

California, Colorado, Florida, Georgia, Indiana, Kansas, Michigan, New York

2017-06-29

Active, closed

A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

NCT03162536Lymphoma, B-Cell, Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia

DrugNemtabrutinib

ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)

Phase 1/2

190

Arizona, California, Colorado, Michigan, Minnesota, North Carolina, Ohio, Tennessee

2017-06-26

Active, closed

Extended Treatment Protocol for Subjects Continuing to Benefit From Ibrutinib.

NCT03229200Lymphoma, B-Cell, Lymphoma, Non-Hodgkin, Leukemia, B-cell, Graft Vs Host Disease

DrugIbrutinib

Pharmacyclics Switzerland GmbH

Phase 4

297

California, Georgia, Illinois, Kentucky, Massachusetts, Michigan, Nevada, New Jersey

2017-05-22

Active, closed

Evaluation of the Personal KinetiGraph™ (PKG™) to Improve Insight Into Parkinson's Disease Status

NCT03741920Parkinson Disease

Global Kinetics Corporation

Not applicable

231

California, Florida, Kansas, Maryland, Michigan, New York, Texas

2017-05-17

Active, closed

Study of Nivolumab in Combination With Ipilimumab or Standard of Care Chemotherapy Compared to the Standard of Care Chemotherapy Alone in Treatment of Participants With Untreated Inoperable or Metastatic Urothelial Cancer

NCT03036098Urothelial Cancer

DrugsYervoy·Ipilimumab·Opdivo·Nivolumab

Bristol-Myers Squibb

Phase 3

1,314

Alaska, California, Florida, Georgia, Illinois, Louisiana, Massachusetts, Michigan

2017-03-24

Active, closed

A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-cell Non-hodgkin's Lymphoma

NCT03075696Non-Hodgkin's Lymphoma

DrugsGlofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 1/2

940

Michigan, Missouri, New York, Pennsylvania, Washington

2017-02-21

Active, closed

Persona Partial Knee Clinical Outcomes Study

NCT03034811Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Conditional Tibial Condyle or Plateau Fractures

Zimmer Biomet

Not applicable

757

California, Colorado, Illinois, Indiana, Massachusetts, Michigan, New Mexico, South Carolina

2017-02-08

Active, closed

Efficacy and Safety of 177Lu-edotreotide PRRT in GEP-NET Patients

NCT03049189Neuroendocrine Tumors

Drugs177Lu-DOTATOC·Everolimus

ITM Solucin GmbH

Phase 3

324

Arizona, California, Florida, Illinois, Michigan, Texas

2017-02-02

Active, closed

Trident II Tritanium Acetabular Shell Outcomes Study

NCT02999009Arthroplasty, Replacement, Hip

Stryker Orthopaedics

Not applicable

383

Arizona, Florida, Illinois, Louisiana, Michigan, New Jersey, New York, North Carolina

2017-01-20

Active, closed

Ribociclib (LEE011) Rollover Study for Continued Access

NCT02934568Continued Access to Study Treatment(s), Cancers With a Mass, Bulky Tumor, Nodule, Lump, Advanced Cancer, Advanced Solid Tumors, Advanced Solid Malignancies

DrugRibociclib

Novartis Pharmaceuticals

Phase 2

Alabama, Massachusetts, Michigan, New York, Tennessee

2016-12-15

Active, closed

A Study of Abemaciclib (LY2835219) in Participants With Non-Small Cell Lung Cancer or Breast Cancer

NCT02779751Non Small Cell Lung Cancer, Breast Cancer

DrugsAnastrozole·Abemaciclib·Pembrolizumab

Eli Lilly and Company

Phase 1

100

Arkansas, California, Colorado, Massachusetts, Michigan, New York

2016-11-14

Active, closed

Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

NCT02803957Mitral Valve Insufficiency

NeoChord

Not applicable

585

California, District of Columbia, Georgia, Indiana, Maryland, Michigan, New York, Pennsylvania

2016-11-03

Active, closed

A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma

NCT02773030Multiple Myeloma

DrugsIberdomide·Darzalex·Velcade·Carfilzomib

Celgene

Phase 1/2

466

Arizona, Arkansas, Georgia, Illinois, Kansas, Maryland, Massachusetts, Michigan

2016-10-14

Active, closed

Lenvatinib/Everolimus or Lenvatinib/Pembrolizumab Versus Sunitinib Alone as Treatment of Advanced Renal Cell Carcinoma

NCT02811861Renal Cell Carcinoma

DrugsSunitinib·Everolimus·Lenvatinib·Pembrolizumab

Eisai Inc.

Phase 3

1,069

California, Florida, Illinois, Kansas, Louisiana, Maryland, Massachusetts, Michigan

2016-10-13

Recruiting

MEASuRE: Metreleptin Effectiveness And Safety Registry

NCT02325674Generalised Lipodystrophy, Partial Lipodystrophy

DrugMetreleptin

Chiesi Farmaceutici S.p.A.

Observational

100

Alabama, California, Georgia, Illinois, Kansas, Louisiana, Maryland, Michigan

2016-10-11

Active, closed

Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide Fixed Dose Combination in Adolescents and Children With Human Immunodeficiency Virus-1

NCT02881320HIV-1 Infection

DrugB/F/TAF

Gilead Sciences

Phase 2/3

177

District of Columbia, Florida, Georgia, Michigan, New York, North Carolina, Pennsylvania, Tennessee

2016-09-21

Active, closed

Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung Cancer

NCT02609776Non-Small-Cell Lung Cancer

DrugsLazertinib·Amivantamab·Pemetrexed·Carboplatin

Janssen Research & Development, LLC

Phase 1

751

California, Florida, Illinois, Maryland, Massachusetts, Michigan, Minnesota, Missouri

2016-05-24

Active, closed

A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer

NCT02711553Biliary Tract Cancer, Metastatic Cancer, Advanced Cancer

DrugsRamucirumab·Gemcitabine·Cisplatin

Eli Lilly and Company

Phase 2

309

Arizona, California, District of Columbia, Florida, Michigan, Missouri, Pennsylvania, Tennessee

2016-05-19

Active, closed

A Study of Acalabrutinib in Combination With Rituximab + (Bendamustine or Venetoclax) in Subjects With MCL

NCT02717624Mantle Cell Lymphoma (MCL)

DrugAcalabrutinib

Acerta Pharma BV

Phase 1

Kentucky, Michigan, New Jersey, New York, Ohio, Tennessee, Texas, Washington

2016-04-20

Active, closed

A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.

NCT02734004Ovarian, Breast, SCLC, Gastric Cancers

DrugsAvastin·Olaparib·Durvalumab·Bevacizumab

AstraZeneca

Phase 1/2

264

Georgia, Maryland, Massachusetts, Michigan, Missouri, Ohio, Pennsylvania

2016-03-17

Active, closed

Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer

NCT02516241Urothelial Cancer

DrugsTremelimumab·Durvalumab·Gemcitabine·Cisplatin

AstraZeneca

Phase 3

1,126

California, Colorado, Connecticut, Florida, Georgia, Kentucky, Massachusetts, Michigan

2015-11-02

Recruiting

CAR-T Long Term Follow Up (LTFU) Study

NCT02445222Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program

Novartis Pharmaceuticals

Phase 3

1,105

Arizona, California, Georgia, Illinois, Kansas, Massachusetts, Michigan, Minnesota

2015-11-02

Active, closed

Triathlon Tritanium Cone Augments Outcomes Study

NCT02521103Arthroplasty, Replacement, Knee

Stryker Orthopaedics

Not applicable

254

Florida, Illinois, Kentucky, Michigan, Missouri, New Jersey, Oklahoma, Washington

2015-08

Active, closed

Phase 2 Tolerability and Effects of ALK-001 on Stargardt Disease

NCT02402660Stargardt Disease, Stargardt Macular Degeneration, Stargardt Macular Dystrophy, Autosomal Recessive Stargardt Disease 1 (ABCA4-related)

DrugALK-001

Alkeus Pharmaceuticals, Inc.

Phase 2

160

Arizona, California, Colorado, Florida, Indiana, Maryland, Michigan, New York

2015-08

Recruiting

Total Shoulder Arthroplasty Multi-Center Registry

NCT03511586Shoulder Arthroplasty

Arthrex, Inc.

Observational

2,500

Arizona, Colorado, Connecticut, Florida, Illinois, Indiana, Michigan, Missouri

2015-07-28

Recruiting

Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children

NCT02235857Focal Segmental Glomerulosclerosis

Kaneka Medical America LLC

Not applicable

California, Delaware, Florida, Michigan, Minnesota, New York, North Carolina, Ohio

2015-05-03

Active, closed

Transcatheter Mitral Valve Replacement System (TMVR) Pilot Study and The Early Feasibility Study of the TMVR Transseptal System

NCT02322840Mitral Valve Insufficiency

Medtronic Cardiovascular

Not applicable

128

Arizona, California, Georgia, Illinois, Michigan, Minnesota, Missouri, New York

2015-04

Active, closed

Infusion of Apomorphine: Long-term Safety Study

NCT02339064Idiopathic Parkinson's Disease

MDD US Operations, LLC a subsidiary of Supernus Pharmaceuticals

Phase 3

Arizona, California, Colorado, Florida, Georgia, Illinois, Kansas, Michigan

2015-02

Active, closed

A Trial of Vigil for Participants With Ovarian Cancer

NCT02346747Ovarian Cancer, Ovarian Neoplasms

Gradalis, Inc.

Phase 2

Alabama, California, Florida, Georgia, Kentucky, Maine, Massachusetts, Michigan

2015-02

Active, closed

A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion (eNRGy)

NCT02912949Solid Tumours Harboring NRG1 Fusion, NSCLC Harboring NRG1 Fusion, Pancreatic Cancer Harboring NRG1 Fusion, NRG1 Fusion

DrugBispecific

Partner Therapeutics, Inc.

Phase 2

250

Arizona, California, District of Columbia, Florida, Georgia, Illinois, Massachusetts, Michigan

2015-01

Active, closed

Study of Acalabrutinib Alone or in Combination Therapy in Subjects With B-cell Non-Hodgkin Lymphoma

NCT02180711Non Hodgkin Lymphoma

DrugsAcalabrutinib·Lenalidomide·Rituximab

Acerta Pharma BV

Phase 1/2

113

Arizona, California, Florida, Illinois, Kentucky, Louisiana, Michigan, New Jersey

2014-12-29

Active, closed

A Study of Abemaciclib (LY2835219) Combined With Fulvestrant in Women With Hormone Receptor Positive HER2 Negative Breast Cancer

NCT02107703Breast Neoplasms

DrugsAbemaciclib·Fulvestrant

Eli Lilly and Company

Phase 3

669

Arkansas, California, Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan

2014-07-22

Active, closed

PERIGON Pivotal Trial

NCT02088554Aortic Stenosis

Medtronic Cardiac Surgery

Not applicable

1,312

California, Colorado, Connecticut, Florida, Georgia, Maryland, Massachusetts, Michigan

2014-05-12

Active, closed

Zimmer Trabecular Metal Total Ankle PMCF

NCT02038140Degenerative Arthritis, Rheumatoid Arthritis, Post Traumatic Arthritis

Zimmer Biomet

Not applicable

120

California, Michigan, North Carolina, Pennsylvania

2014-03

Active, closed

A Study Evaluating the Safety, Pharmacokinetics (PK), and Preliminary Efficacy of ABBV-399 in Participants With Advanced Solid Tumors

NCT02099058Advanced Solid Tumors Cancer

DrugsTelisotuzumab vedotin·Erlotinib·Osimertinib·Nivolumab

AbbVie

Phase 1

237

Arizona, California, Colorado, Illinois, Massachusetts, Michigan, Missouri, New Jersey

2014-01-15

Active, closed

NOVOCART®3D for Treatment of Articular Cartilage of the Knee

NCT01957722Articular Cartilage of the Femoral Condyle Between 2-6cm2

DrugNOVOCART 3D

Aesculap Biologics, LLC

Phase 3

233

California, Colorado, Florida, Idaho, Illinois, Kentucky, Louisiana, Michigan

2013-12

Active, closed

Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis

NCT01892722Multiple Sclerosis

DrugsAvonex·Fingolimod

Novartis Pharmaceuticals

Phase 3

240

Alabama, California, Florida, Massachusetts, Michigan, New Jersey, Pennsylvania, Utah

2013-07-26

Recruiting

Lysosomal Acid Lipase (LAL) Deficiency Registry

NCT01633489Lysosomal Acid Lipase Deficiency, Cholesterol Ester Storage Disease, Wolman Disease, Acid Cholesteryl Ester Hydrolase Deficiency, Type 2

Alexion Pharmaceuticals, Inc.

Observational

300

Arizona, California, Florida, Georgia, Illinois, Massachusetts, Michigan, Minnesota

2013-05-30

Recruiting

Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy

NCT01429389Down Syndrome, Fetal Aneuploidy

Sequenom, Inc.

Observational

2,000

Alabama, California, Illinois, Iowa, Michigan, New Jersey, South Carolina

2011-05

By invitation

Post-Approval Study of the Implantable Miniature Telescope

NCT01757132AMD

VisionCare, Inc.

Not applicable

770

Arizona, California, Colorado, Florida, Georgia, Michigan, Missouri, New York

2010-08

By invitation

Comprehensive Reverse Shoulder Data Collection

NCT03404778Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects

Zimmer Biomet

Observational

175

Maryland, Michigan, Minnesota, Ohio

2010-03-07

Recruiting

Exactech Shoulder Post Market Clinical Follow-up Study

NCT05603728Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy

Exactech

Observational

20,000

California, Colorado, Florida, Georgia, Illinois, Michigan, New York, North Carolina

2007-07-19

Recruiting

Pompe Pregnancy Sub-Registry

NCT00567073Glycogen Storage Disease Type II (GSD-II), Pompe Disease (Late-onset), Glycogenesis 2 Acid Maltase Deficiency

Genzyme, a Sanofi Company

Observational

Arizona, Florida, Georgia, Indiana, Iowa, Michigan, Missouri, New York

2007-06-18

Active, closed

Comparison of Fulvestrant (FASLODEX™) 250 mg and 500 mg in Postmenopausal Women With Oestrogen Receptor Positive Advanced Breast Cancer Progressing or Relapsing After Previous Endocrine Therapy.

NCT00099437Breast Cancer

DrugFulvestrant

AstraZeneca

Phase 3

736

Arizona, California, Connecticut, Florida, Illinois, Maryland, Michigan, Missouri

2005-02-13

Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 6 October 2026. https://priyalifescience.com/clinical-trials-usa/state/michigan?page=3

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