Donanemab: Administered IV
Placebo: Administered IV
Dexamethasone: Administered IV
This study will investigate different donanemab dosing regimens and their effect on the frequency and severity of ARIA-E in adults with early symptomatic Alzheimer's disease (AD) and explore participant characteristics that might predict risk of ARIA.
Approximately 375 additional participants will be enrolled in addendum 2.
Addendum 3 includes a subset of participants from the main study to receive a single dose.
The study will last approximately 91 weeks and include up to 26 visits in the main study.
| Facility | City | Region | Status |
|---|---|---|---|
| MD First Research - Chandler | Chandler | Arizona | |
| Irvine Clinical Research | Irvine | California | |
| Healthy Brain Clinic | Long Beach | California | |
| California Neuroscience Research Medical Group, Inc. | Sherman Oaks | California | |
| JEM Research Institute | Atlantis | Florida | |
| VIN-Julie Schwartzbard | Aventura | Florida | |
| Excel Medical Clinical Trials | Boca Raton | Florida | |
| K2 Medical Research | Clermont | Florida | |
| Brain Matters Research | Delray Beach | Florida | |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | |
| Finlay Medical Research | Greenacres City | Florida | |
| Infinity Clinical Research, LLC | Hollywood | Florida | |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | |
| ClinCloud - Maitland | Maitland | Florida | |
| K2 Medical Research | Maitland | Florida | |
| ClinCloud - Viera | Melbourne | Florida | |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | |
| Renstar Medical Research | Ocala | Florida | |
| Charter Research - Winter Park | Orlando | Florida | |
| Progressive Medical Research | Port Orange | Florida | |
| Alzheimer's Research and Treatment Center | Stuart | Florida | |
| K2 Medical Research - Tampa | Tampa | Florida | |
| K2 Summit Research | The Villages | Florida | |
| Charter Research - Lady Lake | The Villages | Florida | |
| Alzheimer's Research and Treatment Center | Wellington | Florida | |
| Palm Beach Neurology | West Palm Beach | Florida | |
| Conquest Research | Winter Park | Florida | |
| Columbus Memory Center, LLC | Columbus | Georgia | |
| CenExel iResearch, LLC | Decatur | Georgia | |
| Center for Advanced Research & Education | Gainesville | Georgia | |
| CenExel iResearch, LLC | Savannah | Georgia | |
| MedVadis Research Corporation | Waltham | Massachusetts | |
| Adams Clinical | Watertown | Massachusetts | |
| QUEST Research Institute | Farmington Hills | Michigan | |
| The Cognitive and Research Center of New Jersey | Springfield | New Jersey | |
| Butler Hospital | Providence | Rhode Island | |
| Neurology Clinic, P.C. | Cordova | Tennessee | |
| Gadolin Research | Beaumont | Texas | |
| Kerwin Medical Center | Dallas | Texas | |
| The University of Texas Health Science Center at Houston | Houston | Texas |
+ 9 more sites — see the full list on the official registry below.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05738486 on ClinicalTrials.gov ↗ ← All trials in the USA