Pozelimab + Cemdisiran: Subcutaneous administration as described in the protocol
Cemdisiran: SC administration as described in the protocol
Placebo: SC administration as described in the protocol
Pozelimab: SC administration as described in the protocol
This study is researching the experimental drugs called pozelimab and cemdisiran, and cemdisiran monotherapy. The study is focused on patients with generalized Myasthenia Gravis (gMG). Myasthenia gravis is a disease that causes weakness and fatigue in muscles in the body because the nerves and muscles are not communicating properly.
The aim of the study is to see how effective pozelimab and cemdisiran are when used in combination and when pozelimab and cemdisiran are used alone for patients with gMG.
The study is looking at several other research questions, including:
* What side effects may happen from taking the study drugs
* How the study drugs work inside the body
* How much of the study drugs are in the blood at different times
* Whether the body makes antibodies against pozelimab and cemdisiran (which could make the drugs less effective or could lead to side effects)
| Facility | City | Region | Status |
|---|---|---|---|
| HonorHealth Neurology 2018 | Scottsdale | Arizona | |
| University of California Irvine | Irvine | California | |
| University of Southern California | Los Angeles | California | |
| Colorado Springs Neurological Associates | Colorado Springs | Colorado | |
| SFM Clinical Research, LLC | Boca Raton | Florida | |
| Diverse Clinical Research | Miami | Florida | |
| Aqualane Clinical Research | Naples | Florida | |
| Neurological Services of Orlando | Orlando | Florida | |
| Medsol Clinical Research Center Inc | Port Charlotte | Florida | |
| University of South Florida Morsani Center for Advanced Healthcare | Tampa | Florida | |
| NorthShore University Health System | Glenview | Illinois | |
| St. Elizabeth's Hospital | O'Fallon | Illinois | |
| Northwest Neurology Ltd. - Clinedge - PPDS | Rolling Meadows | Illinois | |
| Wayne State University School of Medicine | Detroit | Michigan | |
| Dayton Center for Neurological Disorders | Centerville | Ohio | |
| University of Cincinnati Gardner Neuroscience Institute | Cincinnati | Ohio | |
| Penn Medicine University City | Philadelphia | Pennsylvania | |
| National Neuromuscular Research Institute | Austin | Texas | |
| Nerve and Muscle Center of Texas | Houston | Texas | |
| Universitair Ziekenhuis Antwerpen | Edegem | Antwerp | |
| AZ Sint-Lucas | Ghent | Oost-Vlaanderen | |
| IMV Pesquisa Neurologica | Porto Alegre | Rio Grande do Sul | |
| Jordy Sinapse Medicina LTDA | Itapevi | São Paulo | |
| Faculdade de Medicina Do ABC | Santo André | São Paulo | |
| Pseg Centro de Pesquisa Clinica S.A | São Paulo | Brazil | |
| Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo | São Paulo | Brazil | |
| University of Alberta | Edmonton | Alberta | |
| London Health Sciences Centre | London | Ontario | |
| Toronto General Hospital | Toronto | Ontario | |
| Peking Union Medical College Hospital | Beijing | Beijing Municipality | |
| Fujian Medical University Union Hospital | Fuzhou | Fujian | |
| Guangdong Hospital of Traditional Chinese Medicine | Guangdong | Guangdong | |
| Nanfang Hospital Southern Medical University | Guangzhou | Guangdong | |
| The University of Hong Kong-Shenzhen Hospital | Shenzhen | Guangdong | |
| The First Affiliated Hospital of Guangzhou University of Chinese Medicine | Guangzhou | Guangzhou | |
| Hainan General Hospital | Haikou | Hainan | |
| Renmin Hospital of Wuhan University - Hubei Provincial People's Hospital | Wuhan | Hubei | |
| Xiangya Hospital Central South University | Changsha | Hunan | |
| The First Hospital of Jilin University | Changchun | Jilin | |
| Qilu Hospital of Shandong University (Qingdan) | Qingdao | Shandong |
+ 76 more sites — see the full list on the official registry below.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05070858 on ClinicalTrials.gov ↗ ← All trials in the USA