Clinical Trials in Rozzano, 2026

A Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)

Takeda

Phase 2

200

Rozzano, Rome, Brescia, Florence

2025-11-03

Recruiting

Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

NCT07291037Non-small Cell Lung Cancer (NSCLC)

DrugsDato-DXd·Docetaxel

AstraZeneca

Phase 3

400

Milan, Monza, Orbassano, Padova, Rozzano

2025-10-31

Active, closed

NCT07076121Pancreatic Ductal Adenocarcinoma

DrugsNavlimetostat·Abraxane·Nab-paclitaxel·Gemcitabine

Bristol-Myers Squibb

Phase 2/3

470

Meldola, Rome, Milan, Rozzano, Pisa, Padova, Naples, Verona

2025-10-23

Recruiting

Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.

NCT07407465Colorectal Cancer, Colorectal Adenocarcinoma, Rectal Adenocarcinoma, Rectal Cancer, Adenocarcinoma

DrugsTrastuzumab deruxtecan·Capecitabine·Bevacizumab

Gruppo Oncologico del Nord-Ovest

Phase 2

Bari, Florence, Milan, Ravenna, Rozzano, Tricase, Modena, Roma

2025-10-20

Recruiting

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

NCT07190248Non-small Cell Lung Cancer

Drugs) Berahyaluronidase alfa·Calderasib·Paraplatin·Pemetrexed

Merck Sharp & Dohme LLC

Phase 3

675

Bolzano, Modena, Meldola, Udine, Rome, Bergamo, Rozzano, Statte

2025-10-08

Recruiting

A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease

NCT07196722Crohn Disease

Janssen Research & Development, LLC

Phase 2/3

1,092

Cagliari, Milan, Monza, Negrar-Verona, Roma, Rozzano, Torino

2025-10-03

Recruiting

Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

NCT07181161Metastatic Prostate Cancer

DrugPalacaparib

AstraZeneca

Phase 1/2

283

Milan, Naples, Roma, Rozzano

2025-10-01

Recruiting

A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

NCT07196748Colitis, Ulcerative

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

Janssen Research & Development, LLC

Phase 3

882

Bologna, Florence, Milan, Negrar-Verona, Roma, Rozzano, San Giovanni Rotondo

2025-10-01

Recruiting

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

NCT07184931Crohn's Disease

DrugDuvakitug

Sanofi

Phase 3

980

Rome, Rozzano, Turin

2025-10-01

Recruiting

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

NCT06979336Ulcerative Colitis

Genentech, Inc.

Phase 2

224

Rome, Brescia, Milan, Rho, Rozzano, San Donato Milanese (MI), Turin, Negrar

2025-09-29

Recruiting

NCT07028853Metastatic Castration Sensitive Prostate Cancer (mCSPC), Hormone Sensitive Prostate Cancer, Prostate Cancer, Cancer of the Prostate

DrugsMevrometostat·Xtandi·Enzalutamide

Pfizer

Phase 3

1,000

Meldola, Ravenna, Rozzano, Orbassano, Rome, Milan, Novara, Padova

2025-09-28

Recruiting

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

NCT07129993Urothelial Cancer, Bladder Cancer

DrugsDato-DXd·Gemcitabine·Cisplatin·Carboplatin

Daiichi Sankyo

Phase 2/3

630

Naples, Roma, Rozzano

2025-09-26

Recruiting

Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)

NCT07116967Plaque Psoriasis

DrugsUstekinumab·Deucravacitinib

Bristol-Myers Squibb

Phase 3

3,040

L’Aquila, Cagliari, Rozzano, Baggiovara, Bologna, Chieti, Naples, Roma

2025-09-22

Recruiting

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype

NCT07190209Chronic Obstructive Pulmonary Disease

DrugLunsekimig

Sanofi

Phase 3

942

Milan, Rozzano, Padova, Pavia, Reggio Emilia, Tradate (Va)

2025-09-16

Recruiting

Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

NCT07011719Metastatic Clear Cell Renal Cell Carcinoma, Advanced Clear Cell Renal Cell Carcinoma

DrugsCasdatifan·Cabozantinib

Arcus Biosciences, Inc.

Phase 3

720

Florence, Genova, Milan, Naples, Padua, Perugia, Rome, Rozzano

2025-09-08

Recruiting

A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)

NCT07164443Metastatic Castration-resistant Prostatic Neoplasms

DrugsJNJ-87189401·Pasritamig

Janssen Research & Development, LLC

Phase 3

1,203

Foggia, Milan, Naples, Padova, Palermo, Roma, Rozzano, Torino

2025-09-02

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

NCT07023289Colorectal Cancer

DrugTelisotuzumab Adizutecan

AbbVie

Phase 2

140

Florence, Rozzano, Naples

2025-09-02

Not yet open

Remimazolam for Colonoscopy in IBD Patients

NCT07161297IBD (Inflammatory Bowel Disease)

DrugsRemimazolam·Midazolam

Humanitas Clinical and Research Center

Phase 4

200

Rozzano

2025-09-01

Recruiting

A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

NCT07043400Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

DrugsLeucovorin·Adrucil·Tislelizumab·Capecitabine

BeOne Medicines

Phase 3

351

Genova, Milan, Pisa, Rozzano

2025-08-27

Recruiting

A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP

NCT06920004Chronic Inflammatory Demyelinating Polyneuropathy, CIDP, CIDP - Chronic Inflammatory Demyelinating Polyneuropathy

DrugsEmpasiprubart·IVIG

argenx

Phase 3

218

Bologna, Pavia, Roma, Rozzano

2025-08-22

Recruiting

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

NCT07070232Advanced Solid Tumor

DrugsBNT326·Paroxetine·Itraconazole·Pumitamig

BioNTech SE

Phase 1/2

1,438

Meldola, Milan, Naples, Roma, Rozzano

2025-08-12

Recruiting

A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

NCT07098338Non-Small Cell Lung Cancer

DrugsRamucirumab·Rilvegostomig·Dato-DXd

AstraZeneca

Phase 2

278

Aviano, Catania, Meldola, Milan, Orbassano, Roma, Rozzano

2025-08-07

Not yet open

"Mini Fluid Challenge Assessment: a Comparison Among Three Hemodynamic Tools"

NCT04934943Sepsis, Shock, Septic, Critically Ill

Humanitas Clinical and Research Center

Observational

Rozzano, Novara

2025-08-01

Recruiting

A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)

NCT06911502Follicular Lymphoma

DrugsPrednisone/Prednisolone·Golcadomide·Bendamustine·Vincristine

Celgene

Phase 3

400

Bologna, Meldola, Rozzano, Pisa, Alessandria, Naples, Torino

2025-07-28

By invitation

Postoperative Complications After Neoadjuvant Chemoradiotherapy or Short-course Radiotherapy and Total Neoadjuvant Treatment: a Multicentric Retrospective Cohort Study

NCT07346248Adult Patients With Locally Advanced Rectal Cancer Indicated to Neoadjuvant Therapy and Surgery

Istituto Clinico Humanitas

Observational

266

Rozzano

2025-07-21

Recruiting

A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma

NCT07069712Gastroesophageal Adenocarcinoma

DrugsSonesitatug Vedotin·Calcium folinate·Rilvegostomig·Trastuzumab deruxtecan

AstraZeneca

Phase 2

100

Florence, Milan, Modena, Pisa, Rozzano, Udine, Vicenza

2025-07-17

Recruiting

A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

NCT06570798Systemic Lupus Erythematosus, Active Refractory Rheumatoid Arthritis

DrugsUplizna·Inebilizumab·Blinatumomab

Amgen

Phase 2

220

Milan, Rozzano, Turin

2025-07-16

Recruiting

A Study to Assess the Effectiveness of Second-Line Therapy of Upadacitinib and Risankizumab in Adult Participants With Crohn's Disease in a Real-World Setting

NCT07073079Crohn's Disease

AbbVie

Observational

250

Castellana Grotte, Monserrato, San Giovanni Rotondo, Rozzano, Milan, Monza, Naples, Turin

2025-07-14

Active, closed

Rezafungin for Treatment of Chronic Pulmonary Aspergillosis (CPA) in Adults With Limited Treatment Options

NCT06794554Chronic Pulmonary Aspergillosis

Mundipharma Research Limited

Phase 2

Genova, Pisa, Roma, Rozzano

2025-06-30

Recruiting

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

NCT06937099Crohn's Disease, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

290

Bologna, Castellana Grotte, Milan, Padova, Pisa, Rho, Roma, Rozzano

2025-06-26

Recruiting

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

NCT06937086Ulcerative Colitis, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

350

Bologna, Castellana Grotte, Milan, Padova, Pisa, Rho, Roma, Rozzano

2025-06-26

Recruiting

Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

NCT06961214Pulmonary Disease, Chronic Obstructive

DrugDepemokimab

GlaxoSmithKline

Phase 3

961

Castelvenere, Foggia, Roma, Catania, Ferrara, Genova, Rozzano

2025-06-23

Active, closed

Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)

NCT06959225Hidradenitis Suppurativa

DrugRuxolitinib

Incyte Corporation

Phase 3

580

Catania, Cona, Florence, Milan, Naples, Roma, Rozzano, Torino

2025-06-23

Active, closed

A Phase 2 Study of CAL101 in Patients With Idiopathic Pulmonary Fibrosis

NCT06736990Idiopathic Pulmonary Fibrosis

Calluna Pharma AS

Phase 2

150

Padova, Roma, Siena, Trieste, Modena, Naples, Rozzano

2025-06-20

Recruiting

A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

NCT07018323Graves' Disease

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 2

210

Rozzano, Acquaviva delle Fonti, Bergamo, Cuneo, Livorno, Milan, Naples, Pavia

2025-06-19

Active, closed

A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab

NCT06880744Ulcerative Colitis

DrugsRisankizumab·Vedolizumab

AbbVie

Phase 3

573

Monserrato, Rozzano, Milan, Naples, Rome, Bologna, Padova, Palermo

2025-06-17

Recruiting

Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET

NCT06784752Somatostatin Receptor Positive (SSTR+), Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET)

DrugOctreotide LAR

Novartis Pharmaceuticals

Phase 3

240

Cona, Genova, Milan, Rozzano, Pisa, Roma

2025-05-30

Recruiting

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

NCT07012395Ulcerative Colitis, Inflammatory Bowel Diseases, Colitis, Colitis, Ulcerative

DrugsSPY001·SPY002·SPY003

Spyre Therapeutics, Inc.

Phase 2

645

Castellana Grotte, Pavia, Legnano, Rozzano, San Donato Milanese, Segrate, Turin, Bologna

2025-05-27

Recruiting

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

NCT06935370Heart Failure

DrugsVicadrostat·Dapagliflozin

Boehringer Ingelheim

Phase 3

4,200

Bergamo, Naples, Pavia, Pisa, Roma, Rozzano

2025-05-20

Recruiting

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma

NCT06977581Asthma

DrugTilrekimig

Pfizer

Phase 2

252

Monserrato, Reggio Emilia, Rozzano, Orbassano, Salerno, Torino, Siena

2025-05-20

By invitation

p-PHOTOLARYNX- ANTHEM: Photon-Counting CT in Laryngeal Cancer Staging

NCT07603167Laryngeal Cancer, Laryngeal Carcinoma

Humanitas University

Observational

Rozzano

2025-05-16

Recruiting

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

NCT06925737Prostate Cancer, Prostatic Neoplasms

DrugsIfinatamab Deruxtecan·Prednisolone·Prednisone·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

1,440

Milan, Rozzano, Rome, Siena, Arezzo, Bergamo, Foggia, Terni

2025-05-13

Recruiting

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

NCT06499285Myelodysplastic Syndromes

DrugElritercept

Takeda

Phase 3

225

Ancona, Turin, Florence, Milan, Pavia, Reggio Calabria, Rome, Rozzano

2025-05-06

Recruiting

A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

NCT06747351Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

DrugsTAK-881·Phesgo

Takeda

Phase 3

Milan, Rozzano, Orbassano, Brescia, Genova, Messina, Pavia, Pisa

2025-05-06

Recruiting

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

NCT06921785Hepatocellular Carcinoma

DrugsRilvegostomig·Tremelimumab·Atezolizumab·Bevacizumab

AstraZeneca

Phase 3

1,220

Bologna, Milan, Palermo, Perugia, Pisa, Roma, Rozzano

2025-05-06

Active, closed

Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

NCT06813911Atherosclerotic Cardiovascular Disease (ASCVD)

DrugsPelacarsen·Inclisiran

Novartis Pharmaceuticals

Phase 3

246

Ancona, Caserta, Grosseto, Milan, Rozzano, Perugia, Pordenone, Salerno

2025-04-30

Active, closed

A Study of Roginolisib (IOA-244) in Combination With Dostarlimab With or Without Docetaxel in Metastatic Non Small-cell Lung Cancer (NSCLC) Patients

NCT06879717Non-Squamous Non-Small Cell Lung Cancer (NSCLC), Advanced Non Squamous NSCLC

DrugsRoginolisib·Dostarlimab·Docetaxel

iOnctura

Phase 1/2

Meldola, Rozzano

2025-04-22

Recruiting

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

NCT06890884Lymphoma, Large B-Cell, Diffuse

DrugsRituximab Biosimilar·Zilovertamab vedotin·Riabni·Polatuzumab Vedotin

Merck Sharp & Dohme LLC

Phase 2

594

Meldola, Rozzano, Palermo, Alessandria, Milan, Naples, Reggio Emilia

2025-04-11

Active, closed

Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

NCT06822790Hypertriglyceridemia

DrugPlozasiran

Arrowhead Pharmaceuticals

Phase 3

710

Rozzano, Bologna, Brescia, Milan, Palermo, Roma

2025-04-09

Recruiting

Exploring Photon-Counting CT for Enhanced Target Delineation and Dose Accuracy in Personalized Radiotherapy - ANTHEM

NCT07098247Cancer

Istituto Clinico Humanitas

Observational

500

Rozzano

2025-04-04

Recruiting

PRospective Observational Study of STereotactic Body rAdiation Therapy With Androgen Deprivation Therapy for Organ-confined High-risk Prostate Cancer: the PROSTAR Trial

NCT06949254High Risk Prostate Cancer

Istituto Clinico Humanitas

Observational

Bergamo, Milan, Rozzano

2025-04-04

By invitation

Long-term Safety and Efficacy Study of Riliprubart in Participants With CIDP

NCT06859099Polyneuropathy, Inflammatory Demyelinating, Chronic

DrugRiliprubart

Sanofi

Phase 3

300

Genoa, Milan, Rozzano, Rome, Pavia, Pisa

2025-04-01

Active, closed

A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Ulcerative Colitis

NCT06867094Colitis Ulcerative

DrugBalinatunfib

Sanofi

Phase 2

204

Genoa, Milan, Rozzano, Naples, Padua, Rome, Turin, Alessandria

2025-03-28

Recruiting

A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

NCT06644781Esophageal Squamous Cell Carcinoma

DrugsIfinatamab Deruxtecan·Irinotecan·Docetaxel·Paclitaxel

Daiichi Sankyo

Phase 3

510

Milan, Naples, Padova, Rome, Rozzano

2025-03-27

Recruiting

Photon-counting CT Scan vs Standard HRCT Scan in the Identification of Idiopathic Pulmonary Fibrosis

NCT07790614IPF, ILD, Interstitial Lung Disease (ILD), Interstitial Lung Diseases

Istituto Clinico Humanitas

Observational

156

Rozzano

2025-03-25

Recruiting

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

NCT06914128MTAP-deleted Solid Tumors

Bayer

Phase 1/2

450

Aviano, Milan, Roma, Rozzano

2025-03-21

Recruiting

A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

NCT06615479Relapsed or Refractory Multiple Myeloma (RRMM)

DrugsArlo-cel·Carfilzomib·Pomalidomide·Daratumumab

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 3

440

Milan, Rozzano, Turin, Bologna, Genova, Udine

2025-03-12

Recruiting

Study to Provide Continued Access to Treatment for Patients Completing a Previous Trial With Efanesoctocog Alfa

NCT06716814Haemophilia A (Moderate or Severe)

DrugEfanesoctocog alfa

Swedish Orphan Biovitrum

Phase 3

104

Catanzaro, Florence, Milan, Naples, Parma, Rome, Rozzano, Vicenza

2025-03-06

Recruiting

Evaluate Optimization of CRS Profile for Glofit Monotherapy and Glofit+GemOx in R/R Aggressive B-NHL

NCT06806033Relapsed or Refractory Aggressive B-Cell Non-Hodgkins Lymphoma

DrugsGlofitamab·Obinutuzumab·Oxaliplatin·Gemcitabine

Hoffmann-La Roche

Phase 2

130

Naples, Meldola, Brescia, Milan, Rozzano

2025-03-05

Recruiting

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

NCT06671483Psoriatic Arthritis

Cetuximab Plus Platinum and Taxane-based Chemotherapy, Followed by Avelumab and Cetuximab, as First-line Treatment for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) Patients With a PD-L1 Combined Positive Score (CPS)≥1≤19.

Takeda

Phase 3

1,088

Torrette, Rome, Milan, Rozzano, Padova, Florence, Pisa

2025-03-03

Not yet open

Effects of a Single Session of Physiotherapy on Patients Operated for Lumbar Spondylolisthesis

NCT06799975Spondylolisthesis

Istituto Clinico Humanitas

Not applicable

Rozzano

2025-03-01

Recruiting

A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

NCT06764875HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma

DrugsRilvegostomig·Trastuzumab deruxtecan·Trastuzumab·Adrucil

AstraZeneca

Phase 3

840

Cagliari, Florence, Milan, Naples, Padova, Rozzano, Torino, Tricase

2025-03-01

Not yet open

Effects of Action Observation Training and Motor Imagery Delivered by Telerehabilitation in Patients with Parkinson's Disease

NCT06814782Parkinson Disease

Istituto Clinico Humanitas

Not applicable

Rozzano

2025-03-01

Active, closed

A Randomised Phase II Study of Roginolisib in Patients With Advanced/Metastatic Uveal Melanoma

NCT06717126Uveal Melanoma, Ocular Melanoma

DrugRoginolisib

iOnctura

Phase 2

Bari, Naples, Padova, Rozzano, Siena

2025-02-27

Recruiting

NCT06869473Head and Neck Squamous Cell Carcinoma (HNSCC), Recurrent Head and Neck Cancer, Metastatic Head and Neck Cancer

Gruppo Oncologico del Nord-Ovest

Phase 2

Cagliari, Catania, Florence, Milan, Rozzano, Naples, Roma

2025-02-20

Recruiting

A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

NCT06697197Advanced Solid Tumors

DrugsNivolumab and rHuPH20·Opdualag·Bevacizumab

Bristol-Myers Squibb

Phase 1/2

413

Milan, Rozzano

2025-02-17

Recruiting

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

NCT06556563Glioblastoma

DrugsTemozolomide·Keytruda·Pembrolizumab

NovoCure GmbH

Phase 3

741

Torino, Bologna, Milan, Naples, Padova, Rozzano, Siena

2025-02-03

Recruiting

An Ex-US Study to Assess Treatment Persistence With Risankizumab in Adult Participants With Psoriatic Arthritis

NCT06764693Psoriatic Arthritis

AbbVie

Observational

1,200

Rozzano, Milan, Naples, Rome, Ancona, Brescia, Campobasso, Catania

2025-01-31

Active, closed

A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa (RECHARGE 1)

NCT06799000Hidradenitis Suppurativa

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

588

Ancona, Brescia, Catania, Cona, Florence, Rozzano, Modena, Pisa

2025-01-31

Active, closed

Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma

NCT06478212IDH1-mutant Glioma, IDH2-mutant Glioma

DrugsVorasidenib·Temozolomide

Institut de Recherches Internationales Servier

Phase 1/2

Rozzano, Padua, Turin

2025-01-22

Recruiting

A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis

NCT06807424Arthritis, Psoriatic

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Janssen Research & Development, LLC

Phase 3

750

Ancona, Brescia, Catania, Milan, Naples, Pavia, Roma, Rozzano

2025-01-09

Recruiting

A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

NCT06227910Crohn's Disease

DrugsVedolizumab·Upadacitinib

Takeda

Phase 3

396

Milan, Naples, Roma, Rozzano, San Giovanni Rotondo, Torino

2025-01-02

Recruiting

External Validation of the BREF Models

NCT06669312Acute Respiratory Failure, Oxygen Inhalation Therapy, Respiratory Distress

Istituto Clinico Humanitas

Observational

250

Rozzano

2025-01-01

Recruiting

A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma

NCT06600321Advanced Hepatocellular Carcinoma, Metastatic Hepatocellular Carcinoma

DrugsKeytruda·Pembrolizumab

Alnylam Pharmaceuticals

Phase 1

158

Milan, Rozzano, Verona

2024-12-30

Active, closed

A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa Prophylaxis

NCT06752850Haemophilia A (Moderate or Severe), Hemophilia, Classic, Haemophilia, Hemophilia

DrugEfanesoctocog alfa

Swedish Orphan Biovitrum

Phase 4

Milan, Naples, Rozzano

2024-12-19

Active, closed

A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy

NCT06742190Multifocal Motor Neuropathy (MMN), MMN

DrugsEmpasiprubart·Immunoglobulin·IVIG

argenx

Phase 3

154

Florence, Genova, Gussago, Messina, Milan, Roma, Rozzano

2024-12-18

Active, closed

Phase 2 Study of Rapcabtagene Autoleucel in Myositis

NCT06665256Idiopathic Inflammatory Myopathies

DrugRapcabtagene autoleucel

Novartis Pharmaceuticals

Phase 2

Ancona, Brescia, Monza, Milan, Rozzano, Verona

2024-12-17

Recruiting

NCT06667076Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab

Janssen Research & Development, LLC

Phase 2

480

Orbassano, Padova, Ravenna, Roma, Rozzano

2024-12-16

Recruiting

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

NCT06750094Colorectal Neoplasms

DrugsLeucovorin calcium/Levoleucovorin·Amivantamab·Erbitux·Avastin

Janssen Research & Development, LLC

Phase 3

700

Candiolo, Catania, Florence, Milan, Padova, Pisa, Rozzano, Udine

2024-12-12

Active, closed

Study Evaluating AZD7798 for Treatment in Crohn's Disease Patients With an Ileostomy

NCT06681324Crohn's Disease

DrugAZD7798

AstraZeneca

Phase 2

Padova, Roma, Rozzano

2024-12-11

Active, closed

A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Crohn's Disease.

NCT06637631Crohn's Disease

DrugBalinatunfib

Sanofi

Phase 2

260

Milan, Rozzano, Padua, Rome, Pisa

2024-12-10

Active, closed

Nipocalimab in Moderate to Severe Sjogren's Disease

NCT06741969Sjogrens Syndrome

DrugNipocalimab

Janssen Research & Development, LLC

Phase 3

655

Milan, Palermo, Perugia, Pisa, Roma, Rozzano, Udine

2024-12-04

Recruiting

Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor

NCT06472245Patients With Non-Small Cell Lung Cancer

DrugsTedopi·Docetaxel

OSE Immunotherapeutics

Phase 3

363

Meldola, San Filippo, Rozzano, Naples, Orbassano, Legnago, Genova, Lecce

2024-12-03

Active, closed

A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab

NCT06706817Chronic Rhinosinusitis With Nasal Polyps

AstraZeneca

Phase 3

181

Bologna, Catania, Florence, Padua, Pisa, Roma, Rozzano

2024-12-03

Recruiting

Image-Based Prediction of Ventricular Tachycardias in Post-Myocarditis Patients: an International Multicenter Case-control Study

NCT06730607Myocarditis, Ventricular Arrhythmia

Centro Medico Teknon

Observational

150

Rozzano, Pisa

2024-12-02

Recruiting

A Study to Investigate Safety and Effectiveness of Tacabrutideg (BGB-16673) in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

NCT06634589B-cell Malignancy, Relapsed Cancer, Refractory Cancer, B-cell Lymphoma

DrugsTacabrutideg·Mosunetuzumab·Sonrotoclax·Glofitamab

BeOne Medicines

Phase 1/2

Bologna, Milan, Naples, Rozzano, Verona

2024-11-27

Recruiting

Multicenter Analysis of Different Approaches in Segmentectomies in Early-stage Lung Cancer

NCT06737107Early Stage Lung Cancer (I and II), Non-Small Cell Lung Cancer

Scientific Institute San Raffaele

Observational

472

Rozzano, Milan, Rome

2024-11-26

Active, closed

Trial to Evaluate Acasunlimab and Pembrolizumab Combination Superiority Over Standard of Care Docetaxel in Non-Small Cell Lung Cancer (ABBIL1TY NSCLC-06)

NCT06635824PD-L1-positive, Locally Advanced (Unresectable Stage IIIB/C) or Metastatic NSCLC

DrugsDocetaxel·Pembrolizumab

Genmab

Phase 3

191

Monza, Rozzano, Naples, Aviano, Rome, Orbassano, Bergamo, Candiolo

2024-11-25

Recruiting

Stereotactic Body Radiotherapy (SBRT) for Reirradiation of Inoperable Lung Lesions

NCT07401615Non Small Cell Lung Cancer, Pulmonary Stereotactic Radiotherapy

Istituto Clinico Humanitas

Observational

150

Bergamo, Bologna, Catania, Milan, Rozzano, Naples, Roma, Venezia

2024-11-25

Recruiting

A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer

NCT06532006Gastroesophageal-junction Cancer, Monoclonal Antibody, Gastric Cancer, HER2-positive Gastric Cancer

DrugsHLX22·Trastuzumab·Capecitabine·Oxaliplatin

Shanghai Henlius Biotech

Phase 3

550

Caserta, Cremona, Naples, Rozzano, San Giovanni Rotondo, Torrette, Udine

2024-11-22

Recruiting

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

NCT06617325Systemic Lupus Erythematosus

UCB Biopharma SRL

Phase 3

450

Brescia, Genova, Milan, Padova, Pisa, Roma, Rozzano

2024-11-21

Recruiting

LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis

NCT06632457Metabolic Dysfunction Associated Steatohepatitis

Boehringer Ingelheim

Phase 3

1,590

Bologna, Foggia, Milan, Modena, Palermo, Rome, Rozzano, Torino

2024-11-12

Recruiting

A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis

NCT06655155Systemic Sclerosis (SSc)

argenx

Phase 2

Florence, Milan, Modena, Naples, Roma, Rozzano

2024-11-11

Recruiting

A Phase I Study of BAY3498264 Given Together With Sotorasib in Participants Who Have Advanced Solid Cancers With Specific Genetic Changes Called KRASG12C Mutation

NCT06659341Advanced Solid Tumors Harboring KRAS G12C Mutation

Bayer

Phase 1

104

Roma, Rozzano

2024-11-08

Active, closed

Study of Lunsekimig (SAR443765) Compared With Placebo in Adults With High-risk Asthma

NCT06676319Asthma

DrugsBudesonide/Formoterol·Lunsekimig

Sanofi

Phase 2

556

Torette, Monserrato, Cona, Genoa, Milan, Rozzano, Rome, Bergamo

2024-11-07

Active, closed

Induction Chemo+Immunotherapy in Resectable Epithelioid and Biphasic Pleural Mesothelioma (CHIMERA Study)

NCT06155279Pleural Mesothelioma

DrugKeytruda

Istituto Oncologico Veneto IRCCS

Phase 2

Bergamo, Roma, Rozzano, Aviano, Alessandria, Ferrara, Padova, Parma

2024-11-06

Recruiting

Advanced Surgical Simulation Processes in the Correction of Skeletal Defects and Deformities

NCT06380530Musculoskeletal Deformity, Musculoskeletal Abnormalities, Musculoskeletal Disorder

Istituto Ortopedico Rizzoli

Not applicable

100

Bologna, Rozzano, Genova, Milan, Pavia, Roma

2024-10-31

Recruiting

Study of Infantile Lower Limb Malformations and Deformities

NCT06519175Deformity of Limb

Istituto Ortopedico Rizzoli

Observational

1,000

Bologna, Genova, Milan, Pavia, Roma, Rozzano

2024-10-31

Recruiting

A Study to Investigate the Safety and Efficacy of SAR446523 Injected Subcutaneously in Adult Participants With Relapsed/Refractory Myeloma

NCT06630806Plasma Cell Myeloma Refractory

Sanofi

Phase 1

Torette, Rozzano

2024-10-30

Recruiting

Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

NCT06456593Moderately to Severely Active Crohn Disease

DrugObefazimod

Abivax S.A.

Phase 2

212

Bologna, Catanzaro, Milan, Negrar, Pavia, Roma, Rozzano, San Giovanni Rotondo

2024-10-30

Recruiting

The Sagittarius Trial

NCT06490536Colon Cancer Stage II, Colon Cancer Stage III

DrugsFolinic acid·Panitumumab·Pertuzumab·Temozolomide

IFOM ETS - The AIRC Institute of Molecular Oncology

Phase 3

700

Biella, Brescia, Genova, Milan, Rozzano, Novara, Parma, Perugia

2024-10-22

Recruiting

A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

NCT06629779Metastatic Castration-Resistant Prostate Cancer

DrugsMevrometostat·Xtandi·Enzalutamide

Pfizer

Phase 3

900

Meldola, Rome, Rozzano, Cremona, Milan, Naples, Terni, Trento

2024-10-22

Recruiting

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

NCT06662786Colorectal Neoplasms

DrugsLeucovorin calcium/Levoleucovorin·Amivantamab·Erbitux·Cetuximab

Janssen Research & Development, LLC

Phase 3

1,000

Meldola, Milan, Padova, Pisa, Rozzano

2024-10-18

Recruiting

LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis

NCT06632444Metabolic Dysfunction Associated Steatohepatitis (MASH), Liver Fibrosis

Boehringer Ingelheim

Phase 3

1,800

Bologna, Foggia, Milan, Modena, Novara, Palermo, Rome, Rozzano

2024-10-14

Active, closed

A Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease

NCT06388564Chronic Graft-versus-host-disease

DrugsAxatilimab·Ruxolitinib·Methylprednisolone·Prednisolone

Incyte Corporation

Phase 2

130

Bergamo, Bologna, Milan, Rome, Rozzano, Torino

2024-10-11

Recruiting

A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis

NCT06470048Diffuse Cutaneous Systemic Sclerosis

DrugIanalumab

Novartis Pharmaceuticals

Phase 2

200

Ancona, Milan, Rozzano, Modena, Palermo, Pavia, Roma, Verona

2024-10-09

Recruiting

Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN

NCT06527872Lupus Nephritis

GlaxoSmithKline

Observational

300

Rozzano

2024-10-04

Recruiting

Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer

NCT06510374Intermediate Risk Non-Muscle Invasive Bladder Cancer

DrugNadofaragene Firadenovec

Ferring Pharmaceuticals

Phase 3

454

Rome, Rozzano

2024-10-01

Not yet open

Transcatheter Treatment of Tricuspid Valve Regurgitation

NCT06093828Symptomatic Severe Tricuspid Regurgitation

TriFlo Cardiovascular, Inc.

Not applicable

Castel Volturno, Rozzano, San Donato Milanese, Roma

2024-10

Recruiting

Analysis of RATS, VATS and Open Lung Resections After Neoadjuvant Chemo-immunotherapy in Patients Performed in Five Referred Centers

NCT06626243Non-Small Cell Lung Cancer

Scientific Institute San Raffaele

Observational

140

Rozzano, Milan, Rome

2024-09-30

Recruiting

Robotic Assisted Major Lung Resection in Elderly Patients

NCT06496386Lung Cancer

Scientific Institute San Raffaele

Observational

386

Rozzano, Milan

2024-09-30

Active, closed

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

NCT06525220Head and Neck Squamous Cell Carcinoma

DrugsPetosemtamab·Pembrolizumab

Merus B.V.

Phase 3

699

Ancona, Brescia, Cagliari, Meldola, Milan, Naples, Rome, Rozzano

2024-09-25

Recruiting

Regorafenib for Recurrent Meningioma (MIRAGE Trial)

NCT06275919Meningioma, Malignant

DrugRegorafenib

Istituto Oncologico Veneto IRCCS

Phase 2

104

Meldola, Messina, Bagno a Ripoli, Aviano, Rozzano, Bari, Bologna, Florence

2024-09-23

Recruiting

A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis

NCT06559150Non-cystic Fibrosis Bronchiectasis

Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA

Phase 2

284

Bologna, Monza, Rozzano, Pavia, Catania

2024-09-11

Recruiting

A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B

NCT06379789Hemophilia B

Regeneron Pharmaceuticals

Phase 1/2

130

Florence, Milan, Rozzano, Vicenza

2024-09-11

Recruiting

SPAGO: Sirolimus Paclitaxel Angiographic Gain Objective

NCT06373601Coronary Artery Disease, Stenosis Coronary, Coronary Artery Lesion, Percutaneous Coronary Intervention

Fondazione Evidence per Attività e Ricerche Cardiovascolari ONLUS

Not applicable

140

Mercogliano, Bergamo, Brescia, Ferrara, Milan, Rozzano, Naples, Orbassano

2024-09-05

Recruiting

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

NCT06548542Crohn's Disease

DrugsABBV-8736·Trosunilimab·Lutikizumab·Risankizumab

AbbVie

Phase 2

590

Monserrato, San Giovanni Rotondo, Rozzano, Milan, Rome, Turin, Negrar, Catanzaro

2024-09-04

Recruiting

A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

NCT06528314NASH - Nonalcoholic Steatohepatitis, MASH - Metabolic Dysfunction-Associated Steatohepatitis

DrugEfruxifermin

Akero Therapeutics, Inc

Phase 3

2,150

Foggia, San Giovanni Rotondo, Rozzano, Torino, Bologna, Catania, Messina, Milan

2024-09-04

Active, closed

A Study of TAK-279 in Participants With Moderate-to-Severe Plaque Psoriasis

NCT06550076Plaque Psoriasis

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

Takeda

Phase 3

2,099

Rozzano, Catania, Florence

2024-09-04

Active, closed

A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

NCT06581198Lupus Erythematosus, Systemic, Lupus Nephritis

DrugRapcabtagene autoleucel

Novartis Pharmaceuticals

Phase 2

179

Alessandria, Ancona, Genova, Milan, Rozzano, Pescara, Pisa, Pavia

2024-09-04

Not yet open

Niraparib and Temozolomide in Patients Glioblastoma

NCT06258018Glioma, Malignant

DrugsTemodal·Niraparib·Temozolomide

Armando Santoro, MD

Phase 1/2

Rozzano

2024-09

Active, closed

A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma

NCT06425302Lymphoma, Follicular

DrugsEndoxan·Golcadomide·Pegylated liposomal doxorubicin·Bendamustine

Celgene

Phase 2

Rome, Rozzano, Bologna, Naples

2024-08-30

Active, closed

A Phase 1b Trial to Evaluate Safety of MB097 in Combination With Pembrolizumab in Melanoma Patients

NCT06540391Melanoma

DrugsVancomycin·Keytruda·Pembrolizumab

Microbiotica Ltd

Phase 1

Milan, Naples, Rozzano

2024-08-28

Active, closed

Volrustomig Priming Regimens Exploratory Phase II Platform Study

NCT06448754Non-small Cell Lung Cancer

DrugsVolrustomig·Ramucirumab·Pemetrexed·Paclitaxel

AstraZeneca

Phase 2

194

Genoa, Meldola, Milan, Naples, Orbassano, Perugia, Rozzano, Udine

2024-08-27

Recruiting

A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT06290141Chronic Inflammatory Demyelinating Polyneuropathy

DrugsRiliprubart·IVIG

Sanofi

Phase 3

160

Milan, Rozzano, Padua, Bologna

2024-08-21

Recruiting

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

NCT06467357Biliary Tract Cancer

DrugsRilvegostomig·Trastuzumab deruxtecan·Durvalumab·Gemcitabine

AstraZeneca

Phase 3

620

Florence, Milan, Naples, Padova, Roma, Rozzano, Tricase

2024-08-12

Active, closed

Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib

NCT06531109Alopecia Areata

DrugRitlecitinib

Pfizer

Observational

450

Bari, Rozzano, Bologna, Catania, Roma, Rome

2024-08-07

Active, closed

Phase 1b/2 Platform Study of Select Immunotherapy Combinations in Participants With Advanced Non-small Cell Lung Cancer (NSCLC)

NCT06162572Non-small Cell Lung Cancer (NSCLC)

DrugsS095029·Cemiplimab

Servier Bio-Innovation LLC

Phase 1/2

102

Aviano, Meldola, Milan, Naples, Perugia, Roma, Rozzano

2024-08-07

Recruiting

Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation

NCT05014581Critical Illness, Respiratory Failure

DrugsNoradrenaline·Norepinephrine

University of Turin, Italy

Phase 3

420

Rozzano, Orbassano, Milan

2024-08-01

Not yet open

Outcomes of Transanal Tran-section and Single-stapled (TTSS) Ileal Pouch-Anal Anastomosis

NCT06331637Ulcerative Colitis

Istituto Clinico Humanitas

Observational

174

Rozzano

2024-07-31

Active, closed

NCT06459180Cervical Cancer

DrugsTisotumab Vedotin·Vinorelbine·Topotecan·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

686

Bologna, Milan, Monza, Rozzano, Turin, Brescia, Catania, Naples

2024-07-24

Recruiting

A Phase 1/2 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors

NCT06427941Metastatic Hepatocellular Carcinoma, Local Advanced Hepatocellular Carcinoma, Alpha-fetoprotein (AFP)-Producing Gastric Cancer, Extragonadal Yolk Sac Tumors

DrugsTislelizumab·Bevacizumab

BeOne Medicines

Phase 1/2

630

Naples, Padova, Roma, Rozzano

2024-07-23

Active, closed

Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia

NCT06347003Severe Hypertriglyceridemia

DrugPlozasiran

Arrowhead Pharmaceuticals

Phase 3

446

Rozzano, Palermo, Bologna, Brescia, Milan, Roma

2024-07-22

Recruiting

Depemokimab Asthma Imaging and Bronchoscopy Sub-Study

NCT06979323Asthma

DrugDepemokimab

GlaxoSmithKline

Phase 3

150

Catania, Genova, Roma, Rozzano

2024-07-19

Active, closed

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)

NCT06455202Chronic Spontaneous Urticaria

DrugBarzolvolimab

Celldex Therapeutics

Phase 3

976

Genova, Milan, Padova, Rozzano, Salerno, San Donato Milanese, Torino

2024-07-19

Recruiting

A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

NCT06226883Inflammatory Bowel Diseases, Crohn's Disease

DrugZotemtegrast

Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)

Phase 2

385

Bologna, Brescia, Catanzaro, Milan, Negrar, Padova, Roma, Rozzano

2024-07-18

Active, closed

A Study to Test the Effects and Safety of Riliprubart in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) for Which the Usual Treatments do Not Work

NCT06290128Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Polyneuropathy, Inflammatory Demyelinating, Chronic

DrugRiliprubart

Sanofi

Phase 3

109

Milan, Rozzano, Rome, Messina, Palermo, Pavia, Pisa

2024-07-12

Recruiting

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

NCT06324357Metastatic Breast Cancer, Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Esophageal Adenocarcinoma

DrugsZongertinib·Zanidatamab·Trastuzumab emtansine·MFOLFOX6

Boehringer Ingelheim

Phase 1/2

768

Ancona, Candiolo (TO), Meldola (FC), Milan, Misterbianco (CT), Naples, Rozzano

2024-06-28

Active, closed

A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

NCT06468228Hidradenitis Suppurativa

DrugLutikizumab

AbbVie

Phase 3

1,400

Cona, Florence, Rozzano, Naples, Rome, Catania, Milan

2024-06-27

Active, closed

A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

NCT06496178Head and Neck Squamous Cell Carcinoma

DrugPetosemtamab

Merus B.V.

Phase 3

621

Brescia, Cuneo, Milan, Naples, Roma, Rozzano

2024-06-25

Active, closed

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

NCT06388733Glioblastoma, GBM, Brain Neoplasms, Adult, Malignant, Brain Tumor

DrugsTemodar·Niraparib·Temozolomide

Ivy Brain Tumor Center

Phase 3

450

Bologna, Florence, Milan, Rozzano, Naples, Padova, Rome, Torino

2024-06-19

Recruiting

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

NCT06424288Heart Failure

DrugsVicadrostat·Dapagliflozin

Boehringer Ingelheim

Phase 3

6,712

Bergamo, Foggia, Genova, Naples, Pavia, Roma, Rozzano

2024-06-17

Recruiting

A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab

NCT06389136Atopic Dermatitis

DrugsUpadacitinib·Dupilumab

AbbVie

Phase 3

200

L’Aquila, Rozzano, Rome, Milan

2024-06-14

Recruiting

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

NCT06422143Non-small Cell Lung Cancer, NSCLC

DrugsSacituzumab tirumotecan·Nab-paclitaxel·Keytruda·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

851

Naples, Rome, Milan, Monza, Rozzano, Brescia, Genova, Novara

2024-06-10

Active, closed

Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

NCT06082167Head and Neck Squamous Cell Carcinoma

DrugsZanzalintinib·Keytruda·Pembrolizumab

Exelixis

Phase 2/3

600

Candiolo, Brescia, Catania, Milan, Naples, Rome, Rozzano, Verona

2024-06-07

Active, closed

A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE)

NCT06411249Systemic Lupus Erythematosus

DrugBelimumab

GlaxoSmithKline

Phase 4

303

Brescia, Ferrara, Milan, Pisa, Reggio Emilia, Rome, Rozzano

2024-06-06

Recruiting

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

NCT06430801Crohn's Disease

DrugTulisokibart

Merck Sharp & Dohme LLC

Phase 3

1,200

Bari, Monserrato, Rome, Milan, Rozzano, Naples, Turin, Pontedera

2024-06-05

Recruiting

A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

NCT06419374Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis

DrugPegozafermin

89bio, Inc.

Phase 3

762

Bergamo, Foggia, Milan, Novara, Palermo, Roma, Rome, Rozzano

2024-05-24

Recruiting

Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)

NCT06353386Prostatic Neoplasms, Castration-Resistant

DrugsFludrocortisone acetate·Opevesostat·Cabazitaxel·Taxotere

Merck Sharp & Dohme LLC

Phase 1/2

220

Rome, Milan, Rozzano, Verona

2024-05-20

Active, closed

A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy

NCT06321302Diabetic Retinopathy

Boehringer Ingelheim

Phase 2

190

Florence, Milan, Naples, Roma, Rozzano, Torrette Di Ancona

2024-05-15

Active, closed

A Study to Evaluate the Treatment Response and Safety of Two Dose Regimens of Subcutaneous Amlitelimab Compared With Treatment Withdrawal in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis

NCT06407934Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 3

1,541

Milan, Rozzano, Rome, Bologna, Catania, L’Aquila, Pisa, Vicenza

2024-05-08

Recruiting

Italian Registry of Allergen ImmunoTherapy

NCT06499480Allergic Respiratory Disease

Società Italiana di Allergologia, Asma e Immunologia Clinica

Observational

5,000

Rozzano, Florence

2024-05-01

Active, closed

S095035 as a Single Agent and in Combination in Adult Participants With Advanced or Metastatic Solid Tumors With Deletion of MTAP

NCT06188702MTAP-deleted Solid Tumors

DrugTNG462

Servier Bio-Innovation LLC

Phase 1/2

Milan, Rozzano, Verona

2024-04-29

Recruiting

A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer

NCT06319820Non-Muscle Invasive Bladder Neoplasms

DrugGemcitabine

Janssen Research & Development, LLC

Phase 3

641

Arezzo, Bergamo, Brescia, Milan, Roma, Rozzano, Torino

2024-04-18

Active, closed

Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients

NCT06408935Crohn's Disease

DrugsTremfya·Guselkumab

Janssen-Cilag Ltd.

Phase 3

120

Bologna, Milan, Naples, Pontedera Pisa, Rho, Roma, Rozzano, San Giovanni Rotondo

2024-04-17

Recruiting

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

NCT06312176Breast Neoplasms

DrugsLiposomal doxorubicin·Abraxane·Xeloda·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

1,200

Meldola, Aviano, Milan, Rozzano, Bologna, Genova, Roma

2024-04-14

Recruiting

A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)

NCT06330064Recurrent or Metastatic Solid Tumors

DrugIfinatamab Deruxtecan

Daiichi Sankyo

Phase 1/2

680

Candiolo, Milan, Naples, Rome, Rozzano

2024-04-10

Active, closed

A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG)

NCT06211764Non-Muscle Invasive Bladder Neoplasms

DrugsTAR-200·Mitomycin C·Gemcitabine

Janssen Research & Development, LLC

Phase 3

272

Arezzo, Milan, Province of Macerata, Ravenna, Roma, Rozzano, Torino

2024-04-09

Active, closed

A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis

NCT06329401Pulmonary Fibrosis, Progressive Pulmonary Fibrosis, Pulmonary Fibrosis Secondary to Systemic Sclerosis, Pulmonary Fibrosis, Interstitial Lung Disease

DrugPirfenidone

Avalyn Pharma Inc.

Phase 2

375

Torrette, Naples, Bologna, Venezia, Pavia, Milan, Rozzano, Catania

2024-04-03

Active, closed

A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.

NCT06268873Chronic Kidney Disease and Hypertension

DrugBaxdrostat/dapagliflozin

AstraZeneca

Phase 3

2,554

Bologna, Catanzaro, Chiavari, Desio, Milan, Naples, Parma, Rozzano

2024-03-29

Active, closed

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis

NCT06254950Ulcerative Colitis

Takeda

Phase 2

213

Bologna, Milan, Palermo, Rome, Rozzano

2024-03-29

Recruiting

Prospective Observational Study of Localized Angiosarcoma of Any Site: ProStars

NCT06375941Angiosarcoma

Italian Sarcoma Group

Observational

250

Rozzano, Aviano, Orbassano, Bari, Bologna, Florence, Genova, Milan

2024-03-29

Recruiting

Transanal Transection and Single-stapled Anastomosis (TTSS) in Rectal Cancer Patients

NCT06314646Rectal Cancer, Surgery

Istituto Clinico Humanitas

Observational

472

Rozzano

2024-03-26

Active, closed

REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study

NCT06041386Asthma

DrugMepolizumab

GlaxoSmithKline

Phase 4

336

Genova, Monserrato CA, Naples, Pieve Di Soligo TV, Roma, Rozzano, Verona

2024-03-20

Recruiting

An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.

NCT05939414Oligometastatic Prostate Cancer (OMPC)

DrugsPiflufolastat·Lu-PSMA

Novartis Pharmaceuticals

Phase 3

450

Brescia, Cona, Genova, Milan, Rozzano, Pisa, Roma, Negrar

2024-03-12

Recruiting

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

NCT06233461Crohn's Disease

Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma

Takeda

Phase 2

268

Bologna, Milan, Palermo, Roma, Rome, Rozzano

2024-03-05

Active, closed

A Study of CYP-001 in Combination With Corticosteroids in Adults With High-risk aGvHD

NCT05643638Graft Versus Host Disease, Acute

Cynata Therapeutics Limited

Phase 2

Ancona, Milan, Roma, Rozzano, San Giovanni Rotondo, Venezia

2024-03-04

Active, closed

First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer

NCT06239467Advanced Cancer, Breast Cancer, Advanced Solid Tumors, PI3K Gene Mutation

DrugsAtirmociclib·Tucatinib·Ribociclib·Fulvestrant

OnKure, Inc.

Phase 1

200

Milan, Monza, Rozzano

2024-02-26

Active, closed

Study to Assess Speed of Onset and Durability of Effectiveness of Upadacitinib in Adult Participants With Moderate to Severe Crohn's Disease (CD) in Real World Clinical Practice.

NCT05930275Crohn's Disease

AbbVie

Observational

1,200

Monserrato, San Giovanni Rotondo, Rozzano, Milan, Monza, Rome, Turin, Palermo

2024-02-19

Active, closed

NCT06191744Follicular Lymphoma (FL)

DrugsEpcoritamab·Bendamustine·Obinutuzumab·Vincristine

Genmab

Phase 3

1,095

Rozzano, Candiolo, Bologna, Catania, Palermo, Reggio Emilia, Roma

2024-02-05

Active, closed

A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa

NCT06212999Hidradenitis Suppurativa (HS)

DrugPovorcitinib

Incyte Corporation

Phase 3

617

Ancona, Catania, Milan, Pisa, Roma, Rozzano

2024-01-30

Recruiting

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

NCT05902169Glioblastoma, Recurrent Glioblastoma, GBM

DrugsLomustine·Temodal·Temozolomide·Carboplatin

CarThera

Phase 3

560

Bologna, Livorno, Padua, Roma, Rozzano, Torino

2024-01-29

Active, closed

A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.

NCT06143891Chronic Graft Versus Host Disease

DrugsBelumosudil·Prednisolone·Prednisone

Sanofi

Phase 3

260

Torette, Genoa, Milan, Rozzano, Rome, Turin, Bergamo, Bologna

2024-01-23

Recruiting

DEWI: Watch-and-Wait With Dostarlimab in Localized dMMR/MSI-H Gastric/GEJ Adenocarcinoma Phase II Study

NCT06059495Adenocarcinoma - GEJ, Gastric Adenocarcinoma

DrugDostarlimab

GERCOR - Multidisciplinary Oncology Cooperative Group

Phase 2

Milan, Padova, Ravenna, Rozzano, Udine

2024-01-22

Active, closed

A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)

NCT06109272Hepatocellular Carcinoma

DrugsLivmoniplimab·Budigalimab·Tremelimumab·Atezolizumab

AbbVie

Phase 2/3

Rozzano, Milan, Naples, Rome, Bologna, Palermo, Roma

2024-01-11

Recruiting

Phase 1/2 Study of IMC-R117C in Selected Advanced Cancers

NCT06840119Cancer, HLA-A*02:01-positive

Immunocore Ltd

Phase 1/2

600

Roma, Rozzano

2024-01-10

Recruiting

Safety and Efficacy of RVU120 Combined With Venetoclax for Treatment of Relapsed/Refractory AML

NCT06191263Acute Myeloid Leukemia

DrugsRVU120·Venetoclax

Ryvu Therapeutics SA

Phase 2

Meldola, Ancona, Bologna, Brescia, Lecce, Ravenna, Roma, Rozzano

2024-01-05

Recruiting

A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

NCT06179160Solid Tumors

DrugsGEMNabP·INCB161734·INCA33890·Retifanlimab

Incyte Corporation

Phase 1

710

Milan, Rozzano, Verona

2024-01-04

Recruiting

Observational Study Protocol: LIVER-R

NCT06252753Hepatobiliary Cancers

AstraZeneca

Observational

4,000

Naples, Rome, Brescia, Milan, Rozzano, Turin, Monserrato, Pisa

2023-12-20

Active, closed

Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma

NCT05948475Cholangiocarcinoma

DrugTinengotinib

TransThera Sciences (Nanjing), Inc.

Phase 3

200

Ancona, Candiolo, Meldola, Milan, Naples, Parma, Pisa, Rozzano

2023-12-20

Recruiting

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

NCT06129864Locally Advanced Head and Neck Squamous Cell Carcinoma

DrugVolrustomig

AstraZeneca

Phase 3

1,145

Aviano, Florence, Milan, Modena, Naples, Padova, Pavia, Rozzano

2023-12-14

Active, closed

A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib

NCT05734105GIST

DrugsRipretinib·Sunitinib

Deciphera Pharmaceuticals, LLC

Phase 3

Naples, Palermo, Bologna, Milan, Padova, Roma, Rozzano

2023-12-13

Active, closed

A Study to Investigate Efficacy, Safety, and Tolerability of Remibrutinib Compared With Placebo in Adults With CINDU Inadequately Controlled by H1-antihistamines

NCT05976243Chronic Inducible Urticaria

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

362

Ancona, Milan, Rozzano

2023-12-07

Active, closed

Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

NCT06132958Endometrial Cancer

DrugsAbraxane·Adriamycin·Sacituzumab tirumotecan·Taxol

Merck Sharp & Dohme LLC

Phase 3

710

Bologna, Aviano, Rome, Milan, Rozzano, Candiolo, Bari, Brescia

2023-12-06

Active, closed

Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis

NCT06029972Ulcerative Colitis

Gilead Sciences

Phase 2

176

Catanzaro, Milan, Roma, Rozzano

2023-12-05

Active, closed

A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)

NCT06127043Ulcerative Colitis

DrugRosnilimab

AnaptysBio, Inc.

Phase 2

132

Bologna, Cagliari, Catania, Legnano, Milan, Pavia, Rozzano, San Donato

2023-12-04

Active, closed

Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)

NCT06109779Biliary Tract Cancer

DrugsGemcitabine/Cisplatin·Rilvegostomig·Teysuno·Capecitabine

AstraZeneca

Phase 3

760

Florence, Milan, Padova, Pisa, Rozzano, Tricase, Lecce

2023-12-04

Recruiting

The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)

NCT06408441Epithelioid Hemangioendothelioma, Sarcoma,Soft Tissue

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Observational

100

Bologna, Careggi, Rozzano, Milan, Padova, Palermo, Prato, Roma

2023-12-01

Recruiting

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

NCT06215716NASH With Fibrosis, MASH With Fibrosis

DrugEfruxifermin

Akero Therapeutics, Inc

Phase 3

1,650

San Giovanni Rotondo, Rozzano, Torino, Bologna, Foggia, Messina, Milan, Modena

2023-12-01

Recruiting

A Comparative Study Between Early Onset Colorectal Cancer and Late Onset Colorectal Cancer Patients

NCT06326879Colorectal Cancer

Istituto Clinico Humanitas

Observational

340

Rozzano

2023-11-30

Active, closed

A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V2)

NCT06113471NonSegmental Vitiligo

DrugPovorcitinib

Incyte Corporation

Phase 3

450

Brescia, Catania, Milan, Rome, Rozzano

2023-11-27

Active, closed

Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents

NCT06120491Metastatic Castration-Sensitive Prostate Cancer

DrugsSaruparib·Zytiga·Xtandi·Abiraterone acetate

AstraZeneca

Phase 3

1,898

Bari, Genoa, Meldola, Milan, Naples, Padova, Rome, Rozzano

2023-11-21

Active, closed

Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.

NCT06042478Chronic Spontaneous Urticaria

DrugsOmalizumab·Remibrutinib

Novartis Pharmaceuticals

Phase 3

470

Milan, Rozzano, Modena, Roma, Siena

2023-11-15

Active, closed

A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202

NCT06062420Neoplasms, Head and Neck

DrugsRemzistotug·Nelistotug·Belrestotug·Dostarlimab

GlaxoSmithKline

Phase 2

316

Rozzano, Bari, Bologna, Florence, Genova, Milan, Naples, Novara

2023-11-14

Active, closed

Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)

NCT06074588Non-small Cell Lung Cancer (NSCLC)

DrugsTaxotere·Sacituzumab tirumotecan·Pemetrexed·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

556

Meldola, Rome, Milan, Rozzano

2023-11-12

Active, closed

A Study to Evaluate ABP 206 Compared With OPDIVO® (Nivolumab) in Subjects With Unresectable or Metastatic Melanoma

NCT06054555Melanoma

DrugsOpdivo·Nivolumab

Amgen

Phase 3

633

Crema, Meldola, Taormina, Rozzano, Alessandria, Bari, Bergamo, Florence

2023-11-02

Recruiting

Imaging and Biological Markers for Prediction and Identification of Glioblastoma Pseudoprogression: a Prospective Study.

NCT06113705Glioblastoma

Istituto Clinico Humanitas

Not applicable

Rozzano

2023-11-01

Active, closed

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

NCT06052059Ulcerative Colitis

DrugTulisokibart

Merck Sharp & Dohme LLC

Phase 3

1,109

Monserrato, San Giovanni Rotondo, Rome, Milan, Rozzano, Rho, Naples, Palermo

2023-10-25

Active, closed

ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions

NCT05949684Myelodysplastic Syndromes

DrugsEpoetin Alfa·Reblozyl·Luspatercept

Bristol-Myers Squibb

Phase 3

402

Rome, Milan, Rozzano, Turin, Florence, Bologna, Reggio Calabria, Roma

2023-10-24

Recruiting

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

NCT06026410Solid Tumors With HRAS Alterations, Non Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC)

DrugsAdagrasib·Cabozantinib

Kura Oncology, Inc.

Phase 1

300

Bologna, Candiolo, Naples, Rozzano, Verona

2023-10-18

Active, closed

A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation

NCT06045806Multiple Myeloma

DrugsIdecabtagene vicleucel·Endoxan·Fludara·Cytoxan

Celgene

Phase 3

Rozzano, Bologna, Roma

2023-10-16

Active, closed

A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis

NCT06095115Plaque Psoriasis

Janssen Research & Development, LLC

Phase 3

684

Palermo, Parma, Roma, Rozzano

2023-10-12

Recruiting

A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata

NCT06012240Alopecia Areata

An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma

AbbVie

Phase 3

1,500

Florence, L’Aquila, Rozzano, Naples, Rome, Bologna, Brescia, Catania

2023-10-11

Active, closed

Safety and Performance of REGENERA Breast Implant in Women Affected by Malignant Breast Lesion Treated by Lumpectomy

NCT05941299Mastectomy, Segmental, Breast Neoplasm Malignant Female

Tensive SRL

Not applicable

Rozzano, Catania, Milan, Pavia, Pisa, Roma, Torino

2023-09-29

Active, closed

Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2

NCT05911295Urothelial Carcinoma

DrugsDisitamab Vedotin·Keytruda·Gemcitabine·Cisplatin

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

412

Tricase, Genoa, Rozzano, Lombardy, Giugliano in Campania, Bari, Pozzuoli (NA), Lugo

2023-09-22

Active, closed

Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)

NCT06088290Leiomyosarcoma

DrugsLurbinectedin·Doxorubicin

PharmaMar

Phase 3

469

Rozzano, Naples, Aviano, Bologna, Candiolo, Orbassano, Padova, Palermo

2023-09-21

Recruiting

Artificial Intelligence to Implement Cost-saving Strategies for Colonoscopy Screening Based on in Vivo Prediction of Polyp Histology

NCT06041945Colonic Neoplasms

Istituto Clinico Humanitas

Not applicable

1,800

Rozzano

2023-09-21

Active, closed

NCT06047080Large B-Cell Lymphoma

DrugsPolatuzumab Vedotin·Glofitamab·Doxorubicin·Prednisone

Hoffmann-La Roche

Phase 3

1,130

Naples, Bologna, Modena, Genoa, Bergamo, Milan, Rozzano, Catania

2023-09-18

Active, closed

A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)

NCT05904886Hepatocellular Carcinoma

DrugsTiragolumab·Tecentriq·Avastin·Atezolizumab

Hoffmann-La Roche

Phase 3

687

Tricase, Bologna, Rome, Genoa, Rozzano, Palermo, Verona

2023-09-14

Active, closed

A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

NCT05869955Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathy, Systemic Sclerosis, Rheumatoid Arthritis

DrugsZola-cel·Tocilizumab·Fludarabine·Cyclophosphamide

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 1

270

Rome, Rozzano

2023-09-13

By invitation

A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy

NCT05979441Myositis, Active Idiopathic Inflammatory Myopathy, Dermatomyositis, Polymyositis

DrugEfgartigimod PH20

argenx

Phase 3

240

Bari, Milan, Pisa, Roma, Rozzano, Udine

2023-09-12

Active, closed

Durvalumab With Chemotherapy as First Line Treatment in Patients With Advanced Biliary Tract Cancers (aBTCs)

NCT05771480Biliary Tract Cancer

DrugsAlbumin-Bound Paclitaxel·Teysuno·Durvalumab·Oxaliplatin

AstraZeneca

Phase 3

142

Castelfranco Veneto, Foggia, Palermo, Pisa, Rozzano

2023-08-16

Recruiting

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

NCT05983432Non Small Cell Lung Cancer, Esophageal Cancer, Small Cell Lung Cancer, Nasopharyngeal Cancer

DrugIza-bren

SystImmune Inc.

Phase 1

540

Candiolo, Rozzano

2023-08-08

Recruiting

Ischemic And Bleeding Risk Assessment After TAVR

NCT06000943Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement

Niguarda Hospital

Observational

2,500

Milan, Rozzano, San Donato Milanese, Genova, Potenza, Roma, Torino

2023-08-01

Recruiting

A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

NCT05836324Solid Tumors, Advanced Solid Tumors, Metastatic Solid Tumors

DrugsINCA33890·ADG126·Folfiri·Folfox

Incyte Corporation

Phase 1

570

Milan, Rozzano, Verona

2023-07-24

By invitation

Robotic Surgery in Pulmonary Metastasectomy

NCT06466070Primary Solid Tumors

Scientific Institute San Raffaele

Observational

1,650

Rome, Milan, Rozzano

2023-07-11

Recruiting

Study of Futibatinib in Patients With Advanced Cholangiocarcinoma With FGFR2 Fusion or Rearrangement

NCT05727176Advanced Cholangiocarcinoma, FGFR2 Fusions, Gene Rearrangement

DrugFutibatinib

Taiho Oncology, Inc.

Phase 2

120

Bologna, Rozzano, Verona

2023-07-05

Active, closed

Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.

NCT05838768MSIhi or dMMR Advanced Unresectable or Metastatic Solid Tumors, Including Colorectal Cancers

DrugsIrinotecan·Pembrolizumab

Novartis Pharmaceuticals

Phase 1

123

Milan, Rozzano

2023-06-27

Active, closed

Durvalumab and Tremelimumab as First Line Treatment in Participants With Advanced Hepatocellular Carcinoma (HCC)

NCT05883644Advanced Hepatocellular Carcinoma

DrugsTremelimumab·Durvalumab

AstraZeneca

Phase 3

111

Milan, Naples, Padova, Pisa, Rozzano, Turin

2023-06-27

Active, closed

First CORRECT Study of Minimal Residual Disease (MRD) Detection in Colorectal Cancer

NCT06398743Colorectal Cancer

Exact Sciences Corporation

Observational

416

Rozzano, Milan, Naples

2023-06-20

Recruiting

Ganciclovir Resistant/Refractory Cytomegalovirus Infection in SOT Recipients and HSCT Patients

NCT05234723Cytomegalovirus Infections

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

100

Bologna, Rozzano, Palermo, Genova, Milan, Modena, Naples, Padova

2023-06-19

Recruiting

Study of Loncastuximab Tesirine in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) or High-Grade B-Cell Lymphoma (HGBCL) Following CAR-T Therapy Failure

NCT06918912Diffuse Large B-Cell Lymphoma, High-grade B-cell Lymphoma (HGBCL), B-Cell Lymphoma Treatment, Relapsed or Refractory Lymphoma

DrugLoncastuximab Tesirine

Istituto Clinico Humanitas

Phase 2

Alessandria, Bologna, Cuneo, Milan, Rozzano, Roma

2023-06-16

Active, closed

Prospective Observational Study of Effectiveness and Safety of Filgotinib in Participants With Ulcerative Colitis (UC)

NCT05817942Ulcerative Colitis

DrugFilgotinib

Alfasigma S.p.A.

Observational

509

Bari, Milan, Pisa, Negrar, Palermo, Rozzano, Torino

2023-06-12

Active, closed

An Observational Study to Assess Change in Disease Activity and Adverse Events In Adult Participants With Moderate to Severe Active Crohn's Disease (CD)

NCT05841537Crohn's Disease

AbbVie

Observational

1,019

Florence, Rozzano, Milan, Rome, Bari, Bologna, Messina

2023-06-09

Recruiting

Prospective Observational Basket Study of Stereotactic Body Radiation Therapy for OligoMetastatic Patients From Rare Tumors

NCT05903261Oligometastatic Disease

Istituto Clinico Humanitas

Observational

200

Rozzano

2023-06-09

Active, closed

A Study of BMS-986449 With and Without Nivolumab in Participants With Advanced Solid Tumors

NCT05888831Advanced Solid Tumors

DrugsOpdivo·Nivolumab

Bristol-Myers Squibb

Phase 1/2

100

Rozzano, Siena, Bergamo, Roma

2023-06-06

Active, closed

Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)

NCT05607550Metastatic Non-Small Cell Lung Cancer, Advanced Non-Small Cell Lung Cancer, EGFR Exon 20 Mutations

DrugFurmonertinib

ArriVent BioPharma, Inc.

Phase 3

398

Rozzano, Aviano, Roma, Bari, Meldola, Milan

2023-06-01

Recruiting

Evaluation of Performance and Safety of INNEA and INNEA AQUA for the Treatment of Cheek and décolletage Wrinkles

NCT07331181Wrinkle, Aging

Innate srl

Not applicable

Brescia, Rozzano, Roma

2023-06-01

Recruiting

A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]

NCT05895786Myositis

Pfizer

Phase 3

318

Rozzano, Roma, Catania, Milan

2023-05-20

Active, closed

Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid Diseases

NCT05552469Myeloid Diseases

Novartis Pharmaceuticals

Phase 1

Brescia, Rozzano

2023-05-08

Active, closed

An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma

NCT05876754Cholangiocarcinoma

DrugIvosidenib

Servier Affaires Médicales

Phase 3

299

Bologna, Florence, Milan, Naples, Reggio Emilia, Roma, Rozzano, San Giovanni Rotondo

2023-05-03

Active, closed

A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May Have

NCT05831176Eosinophilic Gastritis (EoG), Eosinophilic Duodenitis (EoD), Eosinophilic Gastrointestinal Disease (EGID), Eosinophilic Gastroenteritis

DrugDupilumab

Regeneron Pharmaceuticals

Phase 2

Rozzano, Palermo, Bari, Milan, Pisa, Roma, Rome

2023-05-03

Active, closed

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer

NCT05775159Hepatocellular Carcinoma, Biliary Tract Cancer

DrugsVolrustomig·Rilvegostomig·Lenvatinib·Gemcitabine

AstraZeneca

Phase 2

294

Florence, Milan, Naples, Rozzano

2023-04-24

Recruiting

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

NCT05786924Non-small Cell Lung Cancer, Histiocytic Neoplasm, Histiocytosis, BRAF Gene Mutation

DrugsPanitumumab·Folfiri·Cetuximab·Nab-paclitaxel

Institut de Recherches Internationales Servier

Phase 1/2

554

Milan, Rome, Rozzano

2023-04-18

Active, closed

A Two-part Study to Investigate the Effects in Adults of Two Doses of Golexanolone in Patients With Primary Biliary Cholangitis (PBC) With Fatigue and Cognitive Dysfunction

NCT07304843Primary Biliary Cholangitis (PBC)

Umecrine Cognition AB

Phase 1/2

Milan, Padova, Palermo, Roma, Rozzano, Udine

2023-04-14

Active, closed

Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

NCT05819359Parkinson's Disease

Bial R&D Investments, S.A.

Phase 2

237

Bologna, Brescia, Brindisi, Milan, Naples, Padova, Roma, Rozzano

2023-03-31

Active, closed

ELVN-002 in HER2 Mutant Non-Small Cell Lung Cancer

NCT05650879HER2 Mutant Non-small Cell Lung Cancer, HER2-positive Metastatic Breast Cancer, HER2 Gene Mutation, HER2 Amplification

DrugsELVN-002·Fam-Trastuzumab Deruxtecan-Nxki·Trastuzumab emtansine·Trastuzumab deruxtecan

Enliven Therapeutics

Phase 1

198

Monza, Candiolo, Aviano, Ancona, Roma, Rozzano

2023-03-20

Active, closed

Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer

NCT05445778Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer

DrugsMirvetuximab Soravtansine·Bevacizumab

AbbVie

Phase 3

520

Florence, Meldola, Genoa, Rozzano, Milan, Naples, Rome, Mirano

2023-03-15

Active, closed

Prospective Double Arm Randomized Trial: WBRT Alone and WBRT Plus Silibinin

NCT05793489Brain Metastases, Adult

Istituto Clinico Humanitas

Not applicable

Rozzano

2023-03-06

Recruiting

Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

NCT05677971Alpha1-Antitrypsin Deficiency

DrugFazirsiran

Takeda

Phase 3

160

Milan, Palermo, Pavia, Rozzano

2023-03-06

Active, closed

Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma

NCT05605899High-risk Large B-cell Lymphoma (LBCL)

DrugsAxi-cel·Axicabtagene Ciloleucel·Vincristine·Doxorubicin

Kite, A Gilead Company

Phase 3

300

Bologna, Brescia, Milan, Perugia, Reggio Calabria, Rome, Rozzano

2023-02-10

Active, closed

A Study to Test a Medicine (Fitusiran) Injected Under the Skin for Preventing Bleeding Episodes in Male Adolescent or Adult Participants With Severe Hemophilia

NCT05662319Hemophilia

DrugsAntithrombin·Clotting factor concentrates·Fitusiran

Sanofi

Phase 3

Rozzano, Milan

2023-02-01

Recruiting

Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases

NCT05545007Brain Metastases, Adult

Istituto Clinico Humanitas

Not applicable

146

Brescia, Florence, Rozzano, Milan, Naples, Rome, Terni

2023-01-31

Recruiting

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

NCT05580562H3 K27M, Glioma

DrugDordaviprone

Jazz Pharmaceuticals

Phase 3

510

Bologna, Rome, Milan, Rozzano, Turin, Padova

2023-01-23

Active, closed

A Clinical Trial to Investigate the Long-term Safety and Tolerability, Efficacy, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of ARGX-117 in Adults With Multifocal Motor Neuropathy

NCT05405361Multifocal Motor Neuropathy (MMN)

DrugEmpasiprubart

argenx

Phase 2

Milan, Pisa, Rome, Rozzano

2023-01-18

Active, closed

ABTECT - Maintenance

NCT05535946Ulcerative Colitis

DrugObefazimod

Abivax S.A.

Phase 3

1,116

San Giovanni Rotondo, Rho, Rozzano, San Donato Milanese, Negrar, Alessandria, Bologna, Brescia

2023-01-16

Active, closed

A Study to Evaluate the Long-Term Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease

NCT05668013Crohn Disease, Colitis, Ulcerative

DrugDuvakitug

Teva Branded Pharmaceutical Products R&D LLC

Phase 2

247

Milan, Rozzano

2023-01-11

Active, closed

A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)

NCT05552976Relapsed or Refractory Multiple Myeloma

DrugsMezigdomide·Carfilzomib·Dexamethasone

Bristol-Myers Squibb

Phase 3

606

Meldola, Milan, Rozzano, Bologna, Catanzaro, Lecce, Pisa, Udine

2023-01-10

Recruiting

Alleviant ALLAY-HF Study

NCT05685303Heart Failure

Alleviant Medical, Inc.

Not applicable

700

Rozzano, Milan

2023-01-10

Active, closed

PBI for Breast in Situ Carcinoma of Intermediate Low Risk As Local Adjuvant Treatment

NCT05663294Breast Cancer

Istituto Clinico Humanitas

Not applicable

150

Rozzano

2023-01-09

Active, closed

Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma

NCT05678673Non-Clear Cell Renal Cell Carcinoma

DrugsSunitinib Malate·Zanzalintinib·Sunitinib·Opdivo

Exelixis

Phase 3

317

Rozzano, Candiolo, Arezzo, Bari, Brescia, Meldola, Milan, Naples

2023-01-01

Active, closed

A Study to Assess Safety and Effectiveness of Elafibranor in Adult Participants With Primary Sclerosing Cholangitis.

NCT05627362Primary Sclerosing Cholangitis

DrugElafibranor

Ipsen

Phase 2

Modena, Padova, Palermo, Rozzano, San Giovanni Rotondo

2022-12-29

Active, closed

First in Human Study of AZD9592 in Solid Tumors

NCT05647122Advanced Solid Tumours, Carcinoma Non-small Cell Lung, Head and Neck Neoplasms, Colorectal Neoplasms

DrugsAZD9592·Osimertinib·Leucovorin·Adrucil

AstraZeneca

Phase 1

190

Milan, Orbassano, Rozzano, Verona

2022-12-21

Active, closed

A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Participants With International Prognostic Scoring System Revised (IPSS-R) Low- or Intermediate-risk Myelodysplastic Syndrome (MDS)

NCT05469737Myelodysplastic Syndromes

DrugAzacitidine

Bristol-Myers Squibb

Phase 2/3

230

Rome, Rozzano, Florence, Bologna

2022-12-14

Recruiting

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

NCT05624450Viral Lung Infection and Acute Respiratory Failure

DrugTozorakimab

AstraZeneca

Phase 3

3,527

Arezzo, Brescia, Naples, Roma, Rozzano, Torino

2022-12-13

Recruiting

A Clinical Trial of Study Medicine (Marstacimab) in Pediatric Patients With Hemophilia A or Hemophilia B

NCT05611801Hemophilia A, Hemophilia B

DrugMarstacimab

Pfizer

Phase 3

100

Genoa, Rozzano, Rome, Parma, Torino

2022-12-09

Active, closed

Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation.

NCT05445843Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation

DrugOpnurasib

Novartis Pharmaceuticals

Phase 2

Bari, Rozzano, Roma, Orbassano

2022-12-06

Recruiting

Survival and Prognostic Factors of Squamous Cell Carcinoma of the Nasal Vestibule

NCT05693116Nasal Vestibule Carcinoma, Rhinectomy, Nasal Vestibule, Squamous Cell Carcinoma

Istituto Clinico Humanitas

Observational

300

Rozzano, Cagliari, Milan, Varese

2022-12-01

Active, closed

Dose-finding Study of SAR443122 in Adult Participants With Ulcerative Colitis

NCT05588843Colitis Ulcerative

Sanofi

Phase 2

187

Bolzano, Milan, Rozzano, Rome, Catanzaro, Palermo, Pavia

2022-11-25

Active, closed

A Study to Evaluate MORF-057 in Adults With Moderately to Severely Active UC

NCT05611671Inflammatory Bowel Diseases, Colitis, Ulcerative

DrugZotemtegrast

Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)

Phase 2

280

Milan, Padova, Rozzano, San Giovanni Rotondo, Segrate

2022-11-21

Active, closed

Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis

NCT05583227Eosinophilic Esophagitis

DrugTezepelumab

AstraZeneca

Phase 3

368

Bologna, Milan, Naples, Padova, Pisa, Roma, Rozzano, Verona

2022-11-10

Active, closed

A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS)

NCT05490446Myelodysplastic Syndromes

DrugTebapivat

Agios Pharmaceuticals, Inc.

Phase 2

Milan, Pavia, Rozzano, Turin, Roma

2022-11-07

Recruiting

An Observational Study to Assess the Effectiveness and Safety of a Cemiplimab in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) in Routine Clinical Practice Settings in Europe

NCT05363319Non-small Cell Lung Cancer

DrugCemiplimab

Regeneron Pharmaceuticals

Observational

500

Misterbianco, Florence, Udine, Rozzano, Orbassano, Pisa, Catania, Milan

2022-10-26

Recruiting

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

NCT05552222Multiple Myeloma

DrugsTalquetamab·Teclistamab·Daratumumab·Lenalidomide

Janssen Research & Development, LLC

Phase 3

1,590

Bergamo, Bologna, Florence, Milan, Naples, Pavia, Roma, Rozzano

2022-10-25

Active, closed

A Study of Tirbanibulin Ointment and Diclofenac Sodium Gel for the Treatment of Adult Participants With Actinic Keratosis on the Face or Scalp

NCT05387525Keratosis, Actinic

DrugDiclofenac Sodium

Almirall, S.A.

Phase 4

447

Arezzo, Brescia, Genova, Modena, Naples, Reggio Emilia, Roma, Rozzano

2022-10-24

Active, closed

A Study of Bleximenib in Combination With Acute Myeloid Leukemia (AML) Directed Therapies

NCT05453903Leukemia, Myeloid, Acute

DrugsBleximenib·Idarubicin·Daunorubicin·Cytarabine

Janssen Research & Development, LLC

Phase 1

196

Bologna, Meldola, Milan, Rozzano

2022-10-04

Active, closed

A Study of Guselkumab in Participants With Fistulizing, Perianal Crohn's Disease

NCT05347095Fistulizing Crohns Disease, Perianal Crohns Disease

DrugGuselkumab

Janssen-Cilag Ltd.

Phase 3

288

Milan, Negrar ( Ve), Pisa, Rho, Roma, Rozzano, San Giovanni Rotondo

2022-09-27

Recruiting

Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT05327114Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

DrugNipocalimab

Janssen Research & Development, LLC

Phase 2/3

201

Catania, Genova, Milan, Naples, Orbassano, Pavia, Roma, Rozzano

2022-09-23

Active, closed

Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma

NCT05371093Relapsed/Refractory Follicular Lymphoma

DrugsAxi-cel·Axicabtagene Ciloleucel·Bendamustine·Vincristine

Kite, A Gilead Company

Phase 3

231

Bergamo, Bologna, Milan, Reggio Emilia, Rozzano

2022-09-22

Active, closed

Study of Inupadenant (EOS100850) With Chemotherapy as Second Line Treatment for Nonsquamous Non-small Cell Lung Cancer

NCT05403385Metastatic NSCLC - Non-Small Cell Lung Cancer, Locally Advanced NSCLC - Non-Small Cell Lung Cancer

DrugsPemetrexed·Carboplatin

iTeos Therapeutics

Phase 2

Milan, Rozzano

2022-08-26

Active, closed

A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)

NCT05500222NASH, Cirrhosis, Liver

DrugResmetirom

Madrigal Pharmaceuticals, Inc.

Phase 3

845

San Giovanni Rotondo, Milan, Rozzano, Roma, Torino, Florence, Palermo, Pisa

2022-08-26

Active, closed

Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials

NCT05492578Dermatitis Atopic

DrugAmlitelimab

Sanofi

Phase 2/3

1,856

Milan, Rozzano, Naples, Rome, Turin, Bologna, Catania, Chieti

2022-08-22

Active, closed

An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice

NCT05494606Ulcerative Colitis

AbbVie

Observational

785

Castellana Grotte, Rozzano, Milan, Naples, Rome, Negrar, Palermo, Pisa

2022-08-15

Active, closed

Evaluation of Rifaximin SSD for Delaying Encephalopathy Decompensation in Patients With Cirrhosis

NCT05297448Hepatic Encephalopathy

DrugRifaximin SSD

Bausch Health Americas, Inc.

Phase 3

466

Milan, Naples, Novara, Palermo, Rozzano

2022-08-03

Active, closed

A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)

NCT05458297Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma

DrugsZilovertamab vedotin·Nemtabrutinib

Merck Sharp & Dohme LLC

Phase 2

189

Bologna, Rozzano, Alessandria, Roma

2022-07-21

Active, closed

A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)

NCT05296798Locally Advanced or Metastatic Breast Cancer

DrugsGiredestrant·Phesgo·Pertuzumab·Trastuzumab

Hoffmann-La Roche

Phase 3

922

Naples, Reggio Emilia, Rimini, Rome, Brescia, Milan, Rozzano, Misterbianco (CT)

2022-07-18

Active, closed

Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma

NCT05352672Melanoma

DrugsFianlimab·Cemiplimab·Keytruda·Pembrolizumab

Regeneron Pharmaceuticals

Phase 3

1,546

Naples, San Giovanni Rotondo, Genoa, Rozzano, Candiolo, Pisa, Bari, Brescia

2022-07-14

Active, closed

Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events

NCT05360446Coronary Artery Disease

DrugInclisiran sodium

Novartis Pharmaceuticals

Phase 3

610

Milan, Rozzano, Torino

2022-07-08

Active, closed

Study of INCB123667 in Subjects With Advanced Solid Tumors

NCT05238922Solid Tumors

DrugsRibociclib·Palbociclib·Olaparib·Fulvestrant

Incyte Corporation

Phase 1

291

Milan, Naples, Rome, Rozzano, Verona

2022-07-05

Recruiting

A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer

NCT05365581Gastric Adenocarcinoma, Gastroesophageal Junction (GEJ) Adenocarcinoma, Pancreatic Adenocarcinoma

DrugsASP2138·Ramucirumab·Fluorouracil·Leucovorin

Astellas Pharma Global Development, Inc.

Phase 1

398

Milan, Rozzano, Verona

2022-06-07

Recruiting

The Head and Neck Registry of the European Reference Network on Rare Adult Solid Cancers

NCT05483374Head and Neck Cancer, Nasopharynx Cancer, Nasal Cavity and Paranasal Sinus Cancer, Salivary Gland Cancer

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Observational

13,600

Genova, Milan, Rozzano, Pavia, Prato, Roma

2022-05-31

Active, closed

Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)

NCT05186974Non-small Cell Lung Cancer

DrugsSacituzumab Govitecan·Paraplatin·Keytruda·Cisplatin

Gilead Sciences

Phase 2

193

Brescia, Catania, Parma, Rome, Rozzano

2022-05-30

Recruiting

Durvalumab With Carboplatin and Etoposide Chemotherapy in Pulmonary Large-cell Neuroendocrine Carcinoma (LCNEC)

NCT06418087Pulmonary Large-cell Neuroendocrine Carcinoma

DrugDurvalumab

Gruppo Oncologico Italiano di Ricerca Clinica

Phase 2

Bologna, Viagrande, Meldola, Florence, Rozzano, Padova, Aviano, Roma

2022-05-27

Recruiting

ADT +/- Darolutamide in de Novo Metastatic Prostate Cancer Patients With Vulnerable Functional Ability (PEACE6-Vulnerable)

NCT04916613Prostate Cancer Metastatic

DrugDarolutamide

UNICANCER

Phase 3

300

Bari, Candiolo, Foggia, Meldola, Milan, Naples, Roma, Rozzano

2022-04-19

Active, closed

Olorofim Aspergillus Infection Study

NCT05101187Invasive Aspergillosis

DrugAmbisome

F2G Biotech GmbH

Phase 3

225

Naples, Monza, Rozzano, Genova, Milan, Modena, Perugia, Pisa

2022-03-31

Active, closed

Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC

NCT05301842Hepatocellular Carcinoma

DrugsTremelimumab·Lenvatinib·Durvalumab

AstraZeneca

Phase 3

760

Arezzo, Florence, Milan, Roma, Rozzano, Tricase

2022-03-28

Active, closed

Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)

NCT05224141Small Cell Lung Carcinoma

DrugsPembrolizumab/Vibostolimab·Tecentriq·Paraplatin·Etoposide

Merck Sharp & Dohme LLC

Phase 3

460

Naples, Milan, Rozzano, Rome

2022-03-24

Active, closed

A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC

NCT05211895Non-Small Cell Lung Cancer

DrugsDomvanalimab·Durvalumab

AstraZeneca

Phase 3

791

Bergamo, Roma, Rozzano

2022-02-18

Recruiting

Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)

NCT05263206Pruritus

DrugsFexofenadine·Dupilumab

Sanofi

Phase 3

284

Cona, Florence, Milan, Rozzano, Naples, Rome, Ancona

2022-02-15

Active, closed

Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease

NCT05202509Atherosclerotic Cardiovascular Disease

DrugObicetrapib

NewAmsterdam Pharma

Phase 3

9,541

Ferrara, Milan, Naples, Palermo, Pavia, Rozzano, Terni

2022-02-07

Recruiting

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

NCT05139017DLBCL, Diffuse Large B-Cell Lymphoma

DrugsZilovertamab vedotin·Granulocyte Colony-Stimulating Factor·Riabni·G-Csf

Merck Sharp & Dohme LLC

Phase 2/3

290

Rozzano, Bologna, Naples, Roma

2022-01-14

Active, closed

A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)

NCT04819100Carcinoma, Non-Small-Cell Lung

DrugSelpercatinib

Eli Lilly and Company

Phase 3

152

Bari, Milan, Rozzano, Naples, Orbassano, Padova

2021-12-20

Recruiting

A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

NCT05067283Advanced Solid Tumors

DrugsCalderasib·Leucovorin·Cetuximab·Adrucil

Merck Sharp & Dohme LLC

Phase 1

830

Rozzano, Siena, Naples

2021-12-17

Active, closed

Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-positive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor.

NCT05038735Breast Cancer

DrugsAlpelisib·Fulvestrant

Novartis Pharmaceuticals

Phase 3

210

Bari, Bergamo, Bologna, Florence, Genova, Milan, Rozzano, Palermo

2021-12-17

Active, closed

Long-term Safety and Efficacy Profile of ABX464 in Subjects With Moderate to Severe Active Ulcerative Colitis

NCT05177835Ulcerative Colitis

DrugObefazimod

Abivax S.A.

Phase 2

203

Roma, Rozzano, Verona

2021-12-03

Recruiting

Anti-NKG2A Monoclonal Antibody for AML or MDS Patients Undergoing Haploidentical Transplantation

NCT06892223Acute Myeloid Leukaemia, MDS (Myelodysplastic Syndrome), MPN (Myeloproliferative Neoplasms)

DrugMonalizumab

Istituto Clinico Humanitas

Phase 2

Genova, Rozzano

2021-12-03

Active, closed

Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma

NCT04910022Glioblastoma, Diffuse Glioma

DrugsNMS-03305293·Temozolomide

Nerviano Medical Sciences

Phase 1/2

150

Bologna, Milan, Padova, Rozzano

2021-12-01

Active, closed

Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease

NCT05030428Atherosclerotic Cardiovascular Disease

DrugInclisiran sodium

Novartis Pharmaceuticals

Phase 3

17,004

Bologna, Brescia, Cona, Florence, Grosseto, Pozzilli, Milan, Rozzano

2021-11-23

Recruiting

Open-Label Extension Study of Marstacimab in Hemophilia Participants With or Without Inhibitors

NCT05145127Hemophilia A, Hemophilia B

DrugMarstacimab

Pfizer

Phase 3

245

Genoa, Rozzano, Roma, Milan

2021-11-17

Recruiting

Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis

NCT05935683Chronic Rhinosinusitis

Italian Academy of Rhinology

Observational

5,000

Rozzano

2021-11-01

Recruiting

Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma

NCT04383119Leiomyosarcoma of Ovary, Soft Tissue Sarcoma

DrugsTrabectedin·Gemcitabine

Italian Sarcoma Group

Phase 2

100

Bologna, Meldola, Prato, Rozzano, Aviano, Roma, Candiolo, Orbassano

2021-10-29

Recruiting

First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)

NCT05099172Advanced Non-small Cell Lung Cancer, EGFR Mutation, HER2 Mutation

Bayer

Phase 1/2

400

Aviano, Milan, Orbassano, Parma, Roma, Rozzano, Verona

2021-10-25

Active, closed

A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors

NCT04857372Mesothelioma

Novartis Pharmaceuticals

Phase 1

137

Milan, Rozzano

2021-10-21

Active, closed

AI for Head Neck Cancer Treated With Adaptive RadioTherapy (RadiomicART)

NCT05081531Head and Neck Cancer

Istituto Clinico Humanitas

Not applicable

Rozzano

2021-10-05

Active, closed

Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

NCT05059522Advanced Malignancies, NSCLC, Ovarian Cancer, Urothelial Cancer

DrugsCMP 001·Utomilumab·Talazoparib·Axitinib

Pfizer

Phase 3

Milan, Rozzano, Ancona

2021-09-29

Active, closed

Prediction AlgoriThm for regeneraTive Medicine Approach in knEe OA: New Decision-making Process Based on Patient pRofiliNg (PATTERN)

NCT05447767Osteoarthritis, Knee

Istituto Clinico Humanitas

Not applicable

240

Rozzano

2021-09-27

Active, closed

Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)

NCT04938817Small Cell Lung Carcinoma

DrugsMK-4830·Pembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab·R-DXd

Merck Sharp & Dohme LLC

Phase 1/2

110

Rozzano, Siena, Milan

2021-08-19

Active, closed

Study Assessing Long-teRm Outcomes of dupiluMAb (DUPIXENT®) Treatment in Adult Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)

NCT04959448Chronic Rhinosinusitis With Nasal Polyposis

DrugDupilumab

Regeneron Pharmaceuticals

Observational

717

Rozzano, Catania, Pisa, Siena, Padova, Catanzaro, Genova, Rome

2021-08-12

Active, closed

A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus

NCT04961567Lupus Erythematosus, Systemic

DrugLitifilimab

Biogen

Phase 3

562

Rozzano, Scafati, Brescia, Padova, Pisa, Roma

2021-07-16

Active, closed

Stereotactic PAncreatic RadioTherapy Adjuvant Therapy

NCT05043857Pancreas Cancer

Istituto Clinico Humanitas

Not applicable

Rozzano

2021-07-06

Active, closed

Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

NCT04895358Breast Neoplasms

DrugsLiposomal doxorubicin·Abraxane·Xeloda·Taxol

Merck Sharp & Dohme LLC

Phase 3

342

Rome, Milan, Monza, Rozzano, Bari, Catania, Naples, Padova

2021-06-18

Recruiting

Observational Study on Skeletal Ewing's Sarcoma

NCT04845893Ewing Sarcoma of Bone

Italian Sarcoma Group

Observational

100

Rozzano, Aviano, Candiolo, Bari, Bologna, Florence, Genova, Milan

2021-06-01

Recruiting

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

NCT04895709Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer

DrugsImzokitug·Pumitamig·Docetaxel·Nivolumab

Bristol-Myers Squibb

Phase 1/2

1,109

Rozzano, Candiolo, Milan, Naples, Roma, Siena

2021-05-27

Active, closed

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

NCT04784715Breast Cancer; HER2-positive; Metastatic

DrugsPertuzumab·Trastuzumab deruxtecan·Trastuzumab

AstraZeneca

Phase 3

1,157

Bergamo, Candiolo, Genova, Livorno, Milan, Naples, Padova, Rozzano

2021-04-26

Recruiting

POst-Prostatectomy Ablative Radiation Therapy

NCT04831970Radiation Toxicity

University of Milano Bicocca

Observational

Rozzano, Monza

2021-04-15

Recruiting

Study on Clinical Features and Outcomes of Breast Sarcoma

NCT04749446Breast Sarcoma

Italian Sarcoma Group

Observational

300

Bologna, Milan, Rozzano, Palermo, Aviano, Prato, Roma, Candiolo

2021-04-02

Active, closed

A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)

NCT04586231Carcinoma, Renal Cell

DrugsBelzutifan·Cabozantinib·Lenvatinib

Merck Sharp & Dohme LLC

Phase 3

747

Meldola, Rozzano, Orbassano, Arezzo, Bari, Milan, Pavia, Roma

2021-02-25

Recruiting

Molecular Mechanisms of Disease Relapse After Allogenic Stem Cell Transplantation in MDS Patients

NCT04587856Myelodysplastic Syndromes

Gruppo Italiano Malattie EMatologiche dell'Adulto

Not applicable

Bari, Florence, Genova, Perugia, Roma, Rozzano

2021-02-12

Active, closed

HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

NCT04619004Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor

DrugPatritumab deruxtecan

Daiichi Sankyo

Phase 2

277

Parma, Orbassano, Meldola, Milan, Rozzano

2021-02-02

Recruiting

Sulodexide, VESSEL®, for the Prevention of Recurrent Venous Thromboembolism (The Jason Study)

NCT04257487Venous Thromboembolism, Anticoagulant, Elderly

DrugSulodexide

Arianna Anticoagulazione Foundation

Phase 3

1,455

Rozzano

2020-12-21

Active, closed

A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer

NCT04351555Non-Small Cell Lung Cancer

DrugsTagrisso·Osimertinib·Pemetrexed·Cisplatin

AstraZeneca

Phase 3

358

Bari, Florence, Monza, Orbassano, Padova, Rozzano, Varese

2020-12-16

Recruiting

BRAIN-targeted Goal-directed Therapy in High-risk Patients undeRgOing Major electIve SurgEry: the BRAIN-PROMISE Study

NCT04266574Surgery, Perioperative Complication

Istituto Clinico Humanitas

Not applicable

200

Rozzano

2020-11-17

Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NCT04585750Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor

DrugsRezatapopt·Keytruda·Pembrolizumab

PMV Pharmaceuticals, Inc

Phase 1/2

300

Rome, Milan, Rozzano, Candiolo, Naples

2020-10-29

Active, closed

Immune Response Evaluation in Oligorecurrent and Oligoprogressive Prostate Cancer Patients Treated With SBRT

NCT04624828Oligorecurrent and Oligoprogressive Prostate Cancer Patients

Istituto Clinico Humanitas

Not applicable

Rozzano

2020-10-19

Active, closed

Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

NCT04446117Metastatic Prostate Cancer, Prostate Adenocarcinoma

DrugsZytiga·Xtandi·Abiraterone·Abiraterone acetate

Exelixis

Phase 3

575

Meldola, Rozzano, Sondrio, Trento, Ancona, Florence, Milan, Parma

2020-10-19

Active, closed

CHAMPION-AF Clinical Trial

NCT04394546Atrial Fibrillation, Stroke, Bleeding

DrugsNon-Vitamin K Anticoagulant·NOAC

Boston Scientific Corporation

Not applicable

3,000

Pisa, Florence, Rivoli, Rozzano

2020-10-15

Active, closed

A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions

NCT04538664Carcinoma, Non-Small-Cell Lung

DrugsAmivantamab·Pemetrexed·Carboplatin

Janssen Research & Development, LLC

Phase 3

308

Bologna, Catania, Meldola, Milan, Monza, Ravenna, Roma, Rozzano

2020-10-13

Recruiting

To Evaluate the Safety and Clinical Performance of the ARCHIMEDES Biodegradable Biliary and Pancreatic Stent

NCT04708288Obstructed Biliary and Pancreatic Duct

QualiMed Innovative Medizinprodukte GmbH

Observational

198

Rozzano, Forlì, Pavia, Roma

2020-10-03

Active, closed

Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome

NCT04401748Myelodysplastic Syndrome (MDS)

DrugsVenclexta·Azacitidine·Venetoclax

AbbVie

Phase 3

531

Rozzano, Naples, Rome, Bologna, Reggio Calabria

2020-09-10

Active, closed

Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)

NCT04380636Lung Neoplasms, Carcinoma, Non-Small-Cell Lung

DrugsParaplatin·Taxol·Olaparib·Etoposide

Merck Sharp & Dohme LLC

Phase 3

870

Torrette, Rome, Rozzano, Florence, Lecce, Milan, Modena, Udine

2020-07-06

Active, closed

Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

NCT04270409Plasma Cell Myeloma

DrugsMontelukast·Diphenhydramine·Acetaminophen·Isatuximab

Sanofi

Phase 3

337

Meldola, Rozzano, Ancona, Bologna, Terni

2020-06-16

Recruiting

Para-aortic Lymphnodes Removal During Upfront Pancreaticoduodenectomy

NCT04571294Pancreas Cancer, Pancreaticoduodenal Lymphadenopathy, Pancreas Adenocarcinoma

Humanitas Hospital, Italy

Not applicable

180

Rozzano

2020-05-26

Active, closed

A Study to Assess a PI3Kδ Inhibitor (IOA-244) in Patients With Metastatic Cancers

NCT04328844Solid Tumor, Adult, Non-Hodgkin Lymphoma, Adult, NSCLC, Myelofibrosis

DrugsRoginolisib·Avelumab·Ruxolitinib·Pemetrexed

iOnctura

Phase 1

210

Rozzano, Siena

2020-02-25

Active, closed

A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

NCT04194944Non-Small Cell Lung Cancer

DrugsSelpercatinib·Pemetrexed·Cisplatin·Carboplatin

Eli Lilly and Company

Phase 3

261

Naples, Ravenna, Aviano, Rome, Monza, Milan, Rozzano, Orbassano

2020-02-17

Recruiting

A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer

NCT05999994Neoplasms, Child, Adolescent

DrugsRamucirumab·Vinorelbine·Abemaciclib·Temozolomide

Eli Lilly and Company

Phase 2

105

Bologna, Candiolo, Milan, Padova, Roma, Rozzano

2020-01-22

Active, closed

Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)

NCT04164901Grade 2 Glioma, Residual Glioma, Recurrent Glioma

DrugVorasidenib

Institut de Recherches Internationales Servier

Phase 3

331

Turin, Bologna, Padua, Roma, Rozzano

2020-01-05

Active, closed

A Study of Sasanlimab in People With Non-muscle Invasive Bladder Cancer

NCT04165317Non-muscle Invasive Bladder Cancer

DrugsSasanlimab·Bacillus Calmette-Guerin

Pfizer

Phase 3

1,068

Misterobianco (CT), Cremona, Rozzano, Turin, Reggio Emilia, Arezzo, Bari, Genova

2019-12-30

Active, closed

Long-term Safety and Efficacy of Nemolizumab With Moderate-to-severe Atopic Dermatitis

NCT03989206Moderate-to-Severe Atopic Dermatitis

DrugNemolizumab

Galderma R&D

Phase 3

1,700

Bologna, L’Aquila, Roma, Rome, Rozzano, Vicenza

2019-12-30

Active, closed

Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: The STEMI-DTU Trial

NCT03947619ST Elevation (STEMI) Myocardial Infarction of Anterior Wall

Abiomed Inc.

Not applicable

527

Genoa, Milan, Verona, Rozzano

2019-12-12

Active, closed

Rollover Study for Continued Safety and Tolerability in Subjects Treated With Spartalizumab Alone or in Combination With Other Study Treatments

NCT04058756Advanced Solid Tumors

DrugSpartalizumab

Novartis Pharmaceuticals

Phase 1

120

Milan, Rozzano, Modena, Aviano, Siena, Naples

2019-10-30

Active, closed

A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis

NCT04033445Ulcerative Colitis

DrugGuselkumab

Janssen Research & Development, LLC

Phase 2/3

1,064

Bologna, Milan, Negrar, Padova, Palermo, Rho, Roma, Rozzano

2019-09-26

Recruiting

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

NCT04104776Advanced Solid Tumor, Diffuse Large B Cell Lymphoma, Lymphoma, T-Cell, Mesothelioma, Malignant

DrugsTulmimetostat·Enzalutamide

Novartis Pharmaceuticals

Phase 1/2

300

Bologna, Milan, Roma, Rozzano

2019-09-18

Active, closed

GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors

NCT04083599Malignant Solid Tumor, Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Melanoma

DrugsGEN1042·Adrucil·Nab-paclitaxel·Pemetrexed

Genmab

Phase 1/2

350

Brescia, Cuneo, Milan, Rozzano

2019-09-17

Recruiting

Registry of Subjects at Risk of Pancreatic Cancer

NCT04095195Familial Pancreatic Cancer, BRCA1 Mutation, BRCA2 Mutation, Lynch Syndrome

Associazione Italiana per lo Studio del Pancreas

Observational

1,000

Rozzano, Peschiera del Garda, Milan, Verona

2019-08-20

Active, closed

A Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa in Combination With Obinutuzumab and in Combination With Glofitamab Following a Pre-Treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma

NCT04077723Lymphoma, Non-Hodgkin

DrugsGlofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 1/2

498

Naples, Bergamo, Milan, Rozzano

2019-08-13

Recruiting

Pan Tumor Rollover Study

NCT03899155Cancer

DrugsRucaparib·Sunitinib·Trametinib·Relatlimab

Bristol-Myers Squibb

Phase 2

1,500

Meldola, Rozzano, Roma, Bari, Bergamo, Candiolo, Catania, Genova

2019-08-09

Recruiting

Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure

NCT04033224Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome

Careggi Hospital

Observational

1,000

Empoli, Lido di Camaiore, Rozzano, San Donato Milanese, Monza, Brindisi, Florence, Pavia

2019-07-16

Active, closed

Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, r/r ALL and 1L HR LBCL

NCT03960840Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Diffuse Large B-cell Lymphoma, Acute Lymphoblastic Leukemia

DrugIbrutinib

Novartis Pharmaceuticals

Phase 1/2

217

Bergamo, Milan, Rozzano

2019-06-26

Recruiting

Breast Cancer: Axillary Conservation After Neoadjuvant Chemotherapy in Micro Metastatic Sentinel Lymph Nodes.

NCT04019678Breast Cancer

Istituto Clinico Humanitas

Not applicable

850

Rozzano

2019-06-21

Recruiting

Protocol ITANET - Registry

NCT04282083Gastro-entero Pancreatic Neuroendocrine Tumors

Italian Association Neuroendocrine Tumors

Observational

3,600

Rozzano, Peschiera del Garda, Ancona, Bari, Bologna, Bolzano, Brescia, Brindisi

2019-05-25

Active, closed

Avelumab Program Rollover Study

NCT03815643Solid Tumors

DrugAvelumab

EMD Serono Research & Development Institute, Inc.

Phase 3

205

Naples, Padova, Roma, Rozzano

2019-03-22

Active, closed

A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer

NCT03816163Pancreatic Cancer, Metastatic Pancreatic Cancer, Metastatic Pancreatic Adenocarcinoma

DrugsZolbetuximab·Nab-paclitaxel·Gemcitabine

Astellas Pharma Global Development, Inc.

Phase 2

393

Rozzano, Candiolo, Cremona, Lombardia, Milan, Toscana, Veneto

2019-03-15

Active, closed

Durvalumab With Stereotactic Body Radiation Therapy (SBRT) vs Placebo With SBRT in Early Stage Unresected Non-small Cell Lung Cancer (NSCLC) Patients/ Osimertinib Following SBRT in Patients With Early Stage Unresected NSCLC Harboring an EGFR Mutation

NCT03833154Carcinoma, Non-Small-Cell Lung

DrugDurvalumab

AstraZeneca

Phase 3

724

Florence, Genova, Milan, Orbassano, Padova, Pavia, Roma, Rozzano

2019-03-06

Active, closed

Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

NCT03742895Advanced Solid Neoplasms

DrugOlaparib

Merck Sharp & Dohme LLC

Phase 2

329

Naples, Rozzano, Siena

2018-12-12

Active, closed

A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer

NCT03701334Early Breast Cancer

DrugRibociclib

Novartis Pharmaceuticals

Phase 3

5,101

Ancona, Bergamo, Bologna, Misterbianco, Milan, Rozzano, Palermo, Aviano

2018-12-07

Active, closed

A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy

NCT03690388Differentiated Thyroid Cancer

DrugCabozantinib

Exelixis

Phase 3

187

Viagrande, Catania, Meldola, Genova, Rozzano, Pisa, Torino, Milan

2018-10-05

Active, closed

Study of Durvalumab + Tremelimumab, Durvalumab, and Placebo in Limited Stage Small-Cell Lung Cancer in Patients Who Have Not Progressed Following Concurrent Chemoradiation Therapy

NCT03703297Small Cell Lung Cancer

DrugsTremelimumab·Durvalumab

AstraZeneca

Phase 3

730

Brescia, Milan, Orbassano, Parma, Roma, Rozzano, Terni

2018-09-27

Active, closed

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis

NCT03398135Ulcerative Colitis (UC)

DrugsSkyrizi·Risankizumab

AbbVie

Phase 3

1,242

Genoa, Rozzano, Milan, Rho, Rome, Negrar, Bologna, Catania

2018-08-28

Recruiting

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

NCT03486873Solid Tumors, Hematologic Malignancies

DrugsPembrolizumab/Favezelimab·) Berahyaluronidase alfa·Olaparib·Lenvatinib

Merck Sharp & Dohme LLC

Phase 3

3,500

Bologna, Rome, Milan, Monza, Rozzano, Aviano, Catania, Candiolo

2018-08-21

Active, closed

A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis

NCT03568318Atopic Dermatitis

Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)

AbbVie

Phase 3

1,533

Rome, Rozzano, Ancona, Catania, Milan, Naples

2018-08-09

Active, closed

A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)

NCT03519945Ulcerative Colitis

DrugMirikizumab

Eli Lilly and Company

Phase 3

1,058

Catanzaro, Genova, Pisa, Rho, Roma, Rome, Rozzano, Torino

2018-07-18

Active, closed

Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy

NCT03755791Hepatocellular Carcinoma

DrugsSorafenib·Cabozantinib·Tecentriq·Atezolizumab

Exelixis

Phase 3

837

Tricase, Rozzano, Bologna, Brescia, Milan, Naples, Novara, Roma

2018-06-10

Active, closed

NCT03425643Non-small Cell Lung Cancer

DrugsPemetrexed·Keytruda·Gemcitabine·Cisplatin

Merck Sharp & Dohme LLC

Phase 3

797

Milano, Naples, Meldola, Rozzano, Milan, Monza, Orbassano, Brescia

2018-04-24

Active, closed

A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease

NCT03105102Crohn's Disease

DrugsSkyrizi·Risankizumab

AbbVie

Phase 3

1,336

Torrette, Genoa, Rozzano, Milan, Rho, Rome, Florence, Negrar

2018-04-09

Active, closed

A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433

NCT03345823Crohn's Disease

A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-cell Non-hodgkin's Lymphoma

AbbVie

Phase 3

747

Bologna, Rozzano, Milan, Rome, Negrar, Catania, Catanzaro, Genova

2018-03-21

Active, closed

Study of EGF816 in Combination With Selected Targeted Agents in EGFR-mutant NSCLC

NCT03333343EGFR-mutant Non-small Cell Lung Cancer

DrugsNazartinib·Naporafenib·Capmatinib·Gefitinib

Novartis Pharmaceuticals

Phase 1

105

Ancona, Milan, Rozzano

2018-01-29

Active, closed

Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC)

NCT03301506Primary Biliary Cirrhosis

DrugSeladelpar

Gilead Sciences

Phase 3

340

Modena, Palermo, Rozzano

2017-12-12

Active, closed

Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma

NCT03298451Hepatocellular Carcinoma

DrugsSorafenib·Tremelimumab·Durvalumab

AstraZeneca

Phase 3

1,324

Benevento, Meldola, Milan, Naples, Perugia, Pisa, Roma, Rozzano

2017-10-11

Active, closed

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

NCT03170960Urothelial Carcinoma, Renal Cell Carcinoma, Non-Small Cell Lung Cancer, Castration-resistant Prostate Cancer

DrugsCabozantinib·Tecentriq·Atezolizumab

Exelixis

Phase 1

914

Meldola, Rozzano, Milan, Naples, Pavia, Roma

2017-09-05

Recruiting

An Observational Study on Epithelioid Sarcoma

NCT03099681Epithelioid Sarcoma

Italian Sarcoma Group

Observational

100

Meldola, Milan, Rozzano, Palermo, Candiolo, Bologna, Padova, Prato

2017-08-22

Active, closed

Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer

NCT03155997Breast Cancer

DrugAbemaciclib

Eli Lilly and Company

Phase 3

5,637

Naples, Cona, Meldola, Monza, Milan, Rozzano, Rome, Terni

2017-07-12

Active, closed

A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC

NCT03052608Carcinoma, Non-Small-Cell Lung

DrugsCrizotinib·Lorlatinib

Pfizer

Phase 3

296

Catania, Monza, Milan, Rozzano, Perugia, Pordenone, Parma, Roma

2017-04-27

Active, closed

A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL

NCT02972840Lymphoma, Mantle Cell

DrugsAcalabrutinib·Bendamustine·Rituximab

Acerta Pharma BV

Phase 3

635

Bologna, Milan, Palermo, Parma, Pavia, Reggio Emilia, Rozzano, Turin

2017-04-05

Active, closed

NCT03075696Non-Hodgkin's Lymphoma

DrugsGlofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 1/2

940

Ravenna, Milan, Rozzano

2017-02-21

Recruiting

Severe Asthma Network Italy

NCT06625216Severe Asthma

Società Italiana di Allergologia, Asma e Immunologia Clinica

Observational

5,000

Rozzano

2017-02-17

Active, closed

A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)

NCT03006068Ulcerative Colitis (UC)