Hereditary Influences on Pulmonary Fibrosis Trajectories

NCT07580053 · tracked via the Priya Life Science Italy tracker

Sponsor

Istituto Clinico Humanitas

Phase

Observational

Started

2026-04-01

Last updated

2026-05-12

Condition(s) studied

Interstitial Lung Disease Due to Systemic Disease (Telomere Biology Disorder)Idiopathic Pulmonary Fibrosis (IPF)Telomere DiseaseProgressive Pulmonary FibrosisFamilial Pulmonary Fibrosis

Study summary

The SHIFT (Hereditary Influences on Pulmonary Fibrosis Trajectories) study is a prospective, multicenter, observational cohort study designed to investigate familial pulmonary fibrosis (FPF) within the Italian population.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * A HRCT scan consistent with ILD diagnosis * Age over 18 years old * A genetic test proved variant or a polymorphism consistent with a diagnosis of FPF * Ability to give informed consent for the inclusion in the study Exclusion Criteria: * Patients unable to perform pulmonary function tests

Primary outcome measure(s)

annual relative FVC decline over the observation period — Annual for 5 years
The annual relative decline is defined as the difference between the final and the initial FVC value divided by the initial value, and it will be calculated for each year and for the entire follow-up period.

Trial sites (1)

Facility	City	Region	Status
Francesco Amati	Rozzano	Italy

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Other trials for the same condition

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis Active, not recruiting

A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis Active, not recruiting

A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis. Active, not recruiting

Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF) Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07580053 on ClinicalTrials.gov ↗ ← All trials in Italy