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Trackers› Clinical trials› Maryland
Clinical trial register · United States · industry-sponsored

Clinical Trials in Maryland, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9118 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 06 Oct 2026, 03:16 UTC
9118
Studies in scope
industry-sponsored, all four open statuses
4945
Recruiting now
open to new participants
2189
Lead sponsors
across recruiting studies
Top states
California 5290 Florida 4430 Illinois 2481 Georgia 2368 Arizona 2238
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
AstraZeneca78 Novartis Pharmaceuticals31 Merck Sharp & Dohme LLC29 Eli Lilly and Company28 Pfizer27
State
California5290 Florida4430 Illinois2481 Georgia2368 Arizona2238
All 51 states
Target enrolment
to

Trials with a site in Maryland

1268 of 9118 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Active, closed
A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis
NCT06754462Rheumatoid Arthritis
DrugIMVT-1402
Immunovant Sciences GmbH
Phase 2
120
Arizona, California, Colorado, Florida, Georgia, Illinois, Maryland, Massachusetts
2025-01-10
Recruiting
An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures
NCT06908356Focal Onset Seizure, Primary Generalized Epilepsy
Praxis Precision Medicines
Phase 2
50
Arizona, Florida, Maryland, Missouri, New Jersey, New York, Texas
2025-01-10
Recruiting
A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis
NCT06807424Arthritis, Psoriatic
DrugIcotrokinra
Janssen Research & Development, LLC
Phase 3
750
Arizona, Arkansas, Florida, Illinois, Maryland, Massachusetts, Minnesota, New Mexico
2025-01-09
Recruiting
A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
NCT06588478Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugPirtobrutinib
Loxo Oncology, Inc.
Phase 2
249
Arizona, California, Colorado, Florida, Georgia, Iowa, Kentucky, Maryland
2025-01-03
Recruiting
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
NCT06524830Treatment Resistant Depression
atai Therapeutics, Inc.
Phase 2
142
Arizona, Arkansas, California, Colorado, Florida, Georgia, Illinois, Maryland
2024-12-30
Recruiting
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)
NCT06637423Non-Muscle Invasive Bladder Cancer
DrugSacituzumab tirumotecan
Merck Sharp & Dohme LLC
Phase 1/2
32
California, Florida, Illinois, Maryland
2024-12-20
Active, closed
A Phase 2, Baseline-Controlled Study Evaluating the Safety and Efficacy of PTX-022 (Sirolimus) Topical Gel 3.9% in the Treatment of Cutaneous Venous Malformations
NCT06653842Cutaneous Venous Malformations
DrugQTORIN rapamycin anhydrous
Palvella Therapeutics, Inc.
Phase 2
15
California, Colorado, Maryland, Minnesota, North Carolina, Ohio, Pennsylvania, Utah
2024-12-20
Active, closed
Study of a 4-Dose Regimen of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants From Approximately 2 Months of Age
NCT06736041Pneumococcal Immunization
DrugsM-M-R II vaccine·Prevnar 20 vaccine·RotaTeq·PCV21 vaccine
Sanofi Pasteur, a Sanofi Company
Phase 3
1,714
Arizona, Arkansas, California, District of Columbia, Florida, Idaho, Kansas, Maryland
2024-12-18
Active, closed
"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"
NCT06564818Major Depressive Disorder
DrugCYB003
Cybin IRL Limited
Phase 3
220
Arizona, California, Colorado, Florida, Georgia, Illinois, Louisiana, Maryland
2024-12-17
Active, closed
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of a New Subcutaneous Formulation of Ocrelizumab in Participants With Multiple Sclerosis
NCT07667322Multiple Sclerosis
DrugOcrelizumab
Hoffmann-La Roche
Phase 1
75
California, Florida, Georgia, Maryland, Tennessee
2024-12-17
Recruiting
A Study to Evaluate Safety and Effectiveness of NOA VOLUME Injectable Gel in Adult Participants Compared to JUVÉDERM VOLUMA XC for Improvement of Mid-Face Volume
NCT06734351Mid Face Volume Deficit
AbbVie
Phase 3
231
Alabama, Arizona, California, Florida, Georgia, Louisiana, Maryland, New York
2024-12-16
Recruiting
Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer
NCT06463028Endometrial Cancer
DrugsSerabelisib·Sapanisertib·Paclitaxel
Faeth Therapeutics
Phase 2
40
California, Florida, Maryland, Minnesota, New York, Ohio, Oregon, Pennsylvania
2024-12-12
Recruiting
A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.
NCT05421858Candidemia, Candidiasis, Invasive
DrugsCaspofungin·Fosmanogepix·Fluconazole
Basilea Pharmaceutica
Phase 3
450
Alabama, California, Georgia, Indiana, Kentucky, Maryland, Michigan, Minnesota
2024-12-11
Active, closed
A Trial of Amlenetug (Lu AF82422) in Participants With Multiple System Atrophy (MSA)
NCT06706622Multiple System Atrophy
DrugAmlenetug
H. Lundbeck A/S
Phase 3
401
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Maryland
2024-12-03
By invitation
A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
NCT06679946Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
DrugVutrisiran
Alnylam Pharmaceuticals
Phase 3
700
Arizona, California, District of Columbia, Illinois, Indiana, Kansas, Maryland, Massachusetts
2024-12-03
Active, closed
Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE
NCT06669754Hereditary Angioedema (HAE)
DrugDeucrictibant
Pharvaris Netherlands B.V.
Phase 3
81
Arkansas, California, Maryland, Missouri
2024-12-01
Active, closed
A Safety and Efficacy Study of One-time SAR402663 in Adults With Neovascular Age-related Macular Degeneration
NCT06660667Neovascular Age-related Macular Degeneration
Sanofi
Phase 1/2
66
Arizona, California, Florida, Georgia, Illinois, Maryland, Massachusetts, Nevada
2024-11-21
Recruiting
CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.
NCT06690775Epithelial Ovarian Cancer, Primary Peritoneal, Fallopian Tube Cancer, Endometrioid Ovarian Cancer
DrugsTORL-1-23·Pegfilgrastim
TORL Biotherapeutics, LLC
Phase 2
230
Arizona, California, Connecticut, Florida, Georgia, Illinois, Maryland, Massachusetts
2024-11-20
Active, closed
INJECTABLE COLD ENERGY THERAPY FOR THE MANAGEMENT OF CHRONIC PAIN ASSOCIATED WITH OSTEOARTHRITIS OF THE KNEE
NCT06700109Osteoarthritis (OA) of the Knee
DrugTriamcinolone acetate
Brixton Biosciences, Inc.
Not applicable
263
California, District of Columbia, Florida, Georgia, Illinois, Kansas, Louisiana, Maryland
2024-11-19
By invitation
A Modified Platform Trial of Multiple CAMPs for the Management of Diabetic Foot Ulcers and Venous Leg Ulcers
NCT06453187Diabetic Foot Ulcer, Venous Leg Ulcer
Integra LifeSciences Corporation
Not applicable
350
California, Connecticut, Florida, Georgia, Illinois, Louisiana, Maryland, New York
2024-11-18
Active, closed
A Study to Investigate Sonrotoclax Combined With Zanubrutinib Versus Zanubrutinib Alone in Participants With Previously Untreated Chronic Lymphocytic Leukemia
NCT06637501Chronic Lymphocytic Leukemia
DrugsSonrotoclax·Zanubrutinib
BeOne Medicines
Phase 2
94
Florida, Georgia, Illinois, Maryland, Nebraska, Oregon, Texas, Utah
2024-11-14
Recruiting
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of GIGA-2339 in Participants With Chronic Hepatitis B Virus Infection
NCT07024641Hepatitis B Virus Infection
GigaGen, Inc.
Phase 1
48
Arizona, California, Georgia, Iowa, Kansas, Maryland, Texas, Virginia
2024-11-13
Recruiting
A Research Study to Evaluate the Safety of NNC4004-0002 When Given to Participants With Asymptomatic Hyperuricemia
NCT06859073Healthy Volunteers, Hyperuricemia
Novo Nordisk A/S
Phase 1
60
California, Maryland
2024-11-13
Recruiting
A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis
NCT06655155Systemic Sclerosis (SSc)
argenx
Phase 2
81
Arizona, California, Florida, Illinois, Louisiana, Maryland, Michigan, Pennsylvania
2024-11-11
Active, closed
Study of a Human Metapneumovirus/Respiratory Syncytial Virus mRNA Vaccine Candidate Encapsulated in a Lipid Nanoparticle-based Formulation in Adults Aged 60 Years and Older
NCT06686654Human Metapneumovirus Immunization, Respiratory Syncytial Virus Immunization
DrugHMPV vaccine
Sanofi Pasteur, a Sanofi Company
Phase 1/2
1,530
Arizona, California, Colorado, District of Columbia, Florida, Idaho, Kansas, Maryland
2024-11-11
Recruiting
Evaluation of the Safety and Effectiveness of ARTIA Reconstructive Tissue Matrix Breast Reconstruction (ADORA) in Adult Participants
NCT06575192Breast Reconstruction
AbbVie
Phase 3
264
California, Colorado, Florida, Illinois, Maryland, Missouri, Nevada, New Jersey
2024-11-05
Recruiting
A Study to Evaluate the Pharmacodynamics and Safety of ARCT-810 in Participants With OTCD
NCT06488313OTC Deficiency, Ornithine Transcarbamylase Deficiency, OTCD
Arcturus Therapeutics, Inc.
Phase 2
9
Maryland
2024-11-04
Active, closed
Establishment of ProNephro AKI (NGAL) Cut Off Value for Risk Assessment of Moderate to Severe Acute Kidney Injury in Adults
NCT06652100Acute Kidney Injury
BioPorto Diagnostics
Observational
800
Alabama, California, Connecticut, Illinois, Maryland, Massachusetts, Michigan, New Mexico
2024-10-28
Recruiting
Hyrax Vs. Invisalign Palatal Expander Clinical Study
NCT06662279Malocclusions, Narrow Maxilla, Narrow Maxillary Arch, Crowding
Align Technology, Inc.
Not applicable
36
California, Georgia, Illinois, Maryland
2024-10-25
Active, closed
A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy
NCT06413706Glioma
DrugsAbemaciclib·Temozolomide
Eli Lilly and Company
Phase 2
45
California, Indiana, Maryland, Michigan, Minnesota, Rhode Island, Texas
2024-10-25
Recruiting
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
NCT06439082Sickle Cell Disease
DrugCrizanlizumab
Novartis Pharmaceuticals
Phase 3
354
Alabama, California, District of Columbia, Florida, Georgia, Illinois, Kentucky, Maryland
2024-10-24
Recruiting
Shoulder Innovations Clinical Data Registry
NCT06754150Shoulder Arthroplasty
Shoulder Innovations
Observational
2,500
Alabama, California, Colorado, Florida, Georgia, Maryland, Massachusetts, Michigan
2024-10-23
Recruiting
Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P)
NCT06671132Chronic Pain, Low Back Pain
Evon Medics LLC
Phase 2
220
District of Columbia, Maryland
2024-10-23
Recruiting
Sacral Neuromodulation for Male Overactive Bladder (MOAB)
NCT06511141Overactive Bladder, Urinary Urgency Incontinence, Benign Prostatic Hyperplasia, Prostate Cancer
Axonics, Inc.
Not applicable
150
Alabama, Arizona, California, Florida, Louisiana, Maryland, Michigan, Minnesota
2024-10-22
Active, closed
Leniolisib for Immune Dysregulation in PIDs
NCT06549114Primary Immunodeficiency Disorders (PIDs)
DrugLeniolisib
Pharming Technologies B.V.
Phase 2
12
Maryland
2024-10-21
Recruiting
ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)
NCT06430385Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome
Ionis Pharmaceuticals, Inc.
Phase 1/2
48
California, Colorado, Maryland, Massachusetts, Minnesota, Pennsylvania, Tennessee, Texas
2024-10-21
By invitation
A Study of the Safety and Efficacy of Prime Editing (PM359) in Participants With p47phox Autosomal Recessive Chronic Granulomatous Disease (CGD )
NCT06559176Chronic Granulomatous Disease, Granulomatous Disease, Chronic
Prime Medicine, Inc.
Phase 1/2
12
California, Maryland, Tennessee
2024-10-17
Active, closed
Phase 3 Study of Daraxonrasib (RMC-6236) in Patients With Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
NCT06625320Pancreatic Cancer, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma
DrugsLiposomal Irinotecan·Leucovorin·Cetuximab·Irinotecan
Revolution Medicines, Inc.
Phase 3
500
Arizona, California, Colorado, Florida, Hawaii, Illinois, Maryland, Massachusetts
2024-10-16
Active, closed
A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma
NCT06637371Asthma
DrugAMG 691
Amgen
Phase 1
21
California, Florida, Georgia, Maryland, Massachusetts, Minnesota, North Carolina, Oklahoma
2024-10-16
Recruiting
Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response
NCT06641089Arthritis, Psoriatic
DrugsSonelokimab·Risankizumab
MoonLake Immunotherapeutics AG
Phase 3
600
Arizona, Arkansas, California, Florida, Georgia, Illinois, Louisiana, Maryland
2024-10-15
Active, closed
Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis Naive to Biologic Disease-Modifying Antirheumatic Drug
NCT06641076Arthritis, Psoriatic
DrugSonelokimab
MoonLake Immunotherapeutics AG
Phase 3
960
Arizona, California, Florida, Illinois, Louisiana, Maryland, Michigan, North Carolina
2024-10-15
Recruiting
Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)
NCT06486454Liver Neoplasms, Primary Liver Cancer, Secondary Liver Cancer, Tumor Liver
HistoSonics, Inc.
Observational
5,000
California, Florida, Georgia, Illinois, Louisiana, Maryland, Massachusetts, Michigan
2024-10-14
Active, closed
A Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease
NCT06388564Chronic Graft-versus-host-disease
DrugsAxatilimab·Ruxolitinib·Methylprednisolone·Prednisolone
Incyte Corporation
Phase 2
130
Arizona, California, Colorado, Connecticut, Florida, Illinois, Maryland, Missouri
2024-10-11
Recruiting
Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations
NCT06581432Solid Tumours
DrugZongertinib
Boehringer Ingelheim
Phase 2
588
Alaska, Arizona, California, Connecticut, Florida, Illinois, Indiana, Maryland
2024-10-11
Active, closed
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN2)
NCT06516965Prurigo Nodularis
DrugPovorcitinib
Incyte Corporation
Phase 3
346
Arizona, California, Florida, Kentucky, Maryland, Massachusetts, Michigan, New Hampshire
2024-10-10
Recruiting
Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN
NCT06527872Lupus Nephritis
GlaxoSmithKline
Observational
300
Maryland, North Carolina, Ohio, Tennessee
2024-10-04
Recruiting
Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma
NCT06561048Peripheral T-Cell Lymphoma, Not Otherwise Specified, Angioimmunoblastic T-cell Lymphoma, Follicular T-Cell Lymphoma, Nodal Peripheral T-Cell Lymphoma With TFH Phenotype
DrugsBelinostat·Pralatrexate·Soquelitinib
Corvus Pharmaceuticals, Inc.
Phase 3
150
California, Connecticut, Florida, Georgia, Illinois, Iowa, Maryland, Massachusetts
2024-10-02
Recruiting
ALTO-100 in Bipolar Disorder With Depression (BD-D)
NCT06656416Bipolar Disorder I or II With a Major Depressive Episode
Alto Neuroscience
Phase 2
200
Arizona, Arkansas, California, Colorado, Florida, Georgia, Maryland, Nebraska
2024-10-02
Recruiting
A Phase 2 Study of PCS6422 With Capecitabine in Patients With Advanced or Metastatic Breast Cancer
NCT06568692Breast Cancer, TNBC - Triple-Negative Breast Cancer, HER2-negative Breast Cancer
DrugCapecitabine
Processa Pharmaceuticals
Phase 2
90
Arizona, California, Florida, Indiana, Maryland, New Jersey, New York, Ohio
2024-10-02
Active, closed
A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)
NCT06660394Dravet Syndrome
DrugBexicaserin
Longboard Pharmaceuticals
Phase 3
96
Arkansas, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Maryland
2024-09-25
Active, closed
A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy
NCT06481891Obstructive Cardiomyopathy, Hypertrophic, Non-obstructive Hypertrophic Cardiomyopathy
DrugSotagliflozin
Lexicon Pharmaceuticals
Phase 3
500
Arizona, California, Florida, Georgia, Illinois, Indiana, Maryland, Massachusetts
2024-09-24
Recruiting
A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin PDT
NCT05171894Port-wine Birthmarks, Port-Wine Stain, Nevus Flammeus
Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
Phase 2
84
California, Florida, Maryland, Pennsylvania
2024-09-21
Recruiting
A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
NCT06635148Geographic Atrophy, Macular Degeneration
Janssen Research & Development, LLC
Phase 2/3
274
Arizona, California, Florida, Georgia, Illinois, Indiana, Maine, Maryland
2024-09-19
Active, closed
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC in Adults With Ocular Myasthenia Gravis
NCT06558279Myasthenia Gravis, Ocular
argenx
Phase 3
141
Arizona, California, Florida, Illinois, Maryland, Massachusetts, Michigan, New Jersey
2024-09-18
Recruiting
An Observational Study of Etrasimod in Adult Patients With Moderate to Severe Ulcerative Colitis
NCT06398626Colitis, Ulcerative
DrugEtrasimod
Pfizer
Observational
300
Arizona, California, Colorado, Florida, Illinois, Maryland, New Jersey, New York
2024-09-17
Active, closed
Study of Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection (B-Focus)
NCT06497504Hepatitis B
DrugBepirovirsen
GlaxoSmithKline
Phase 2
153
California, Florida, Maryland, Minnesota, New Jersey
2024-09-17
Active, closed
A Study of Obexelimab in Patients With Systemic Lupus Erythematosus
NCT06559163Systemic Lupus Erythematosus
DrugObexelimab
Zenas BioPharma (USA), LLC
Phase 2
190
Arizona, California, Connecticut, Florida, Georgia, Illinois, Louisiana, Maryland
2024-09-17
Recruiting
A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma
NCT06140524Monoclonal Gammopathy of Undetermined Significance (MGUS), Smoldering Multiple Myeloma (SMM)
DrugLinvoseltamab
Regeneron Pharmaceuticals
Phase 2
116
Maryland, Massachusetts, Michigan, New York, Pennsylvania, Washington
2024-09-16
Active, closed
ABA-101 in Participants With Progressive Multiple Sclerosis
NCT06566261Progressive Multiple Sclerosis
Abata Therapeutics
Phase 1
12
Maryland, New Jersey, Ohio
2024-09-11
Active, closed
A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis
NCT06431373Uveitis, Posterior, Uveitis, Intermediate, Uveitis
Priovant Therapeutics, Inc.
Phase 3
371
Arizona, California, Colorado, Florida, Illinois, Indiana, Kansas, Maryland
2024-09-11
Recruiting
RevCore for In Stent Thrombosis
NCT06394739In-stent Thrombosis
Inari Medical
Observational
100
Connecticut, District of Columbia, Idaho, Maryland, New York, North Carolina, Ohio, Pennsylvania
2024-09-09
Active, closed
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
NCT06616974Pulmonary Hypertension, Heart Failure With Preserved Ejection Fraction
Tectonic Therapeutic
Phase 2
191
Arizona, California, Colorado, Florida, Georgia, Idaho, Kentucky, Maryland
2024-09-04
Recruiting
ATLAS (AltaValve) Pivotal Trial
NCT06465745Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation
4C Medical Technologies, Inc.
Not applicable
450
Arizona, California, Florida, Georgia, Louisiana, Maryland, Massachusetts, Michigan
2024-09-03
Recruiting
A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
NCT06452277Advanced Non-small Cell Lung Cancer, HER2 Mutation
DrugsSevabertinib·Pemetrexed·Cisplatin·Carboplatin
Bayer
Phase 3
555
California, Florida, Georgia, Illinois, Maryland, Massachusetts, Michigan, Minnesota
2024-08-28
Recruiting
Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
NCT06535607Sub-study 1 Cervical Cancer (Volrustomig Monotherapy), Sub-study 2 Head and Neck Squamous Cell Carcinoma (Volrustomig Monotherapy), Sub-study 3 Head and Neck Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy), Sub-study 4 Esophageal Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy)
DrugsVolrustomig·Adrucil·Paclitaxel·Cisplatin
AstraZeneca
Phase 2
257
California, Maryland, New York, Ohio, Pennsylvania
2024-08-22
Recruiting
Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)
NCT06371417Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP), Behçet's Syndrome (BS), Dermatomyositis (DM)
DrugRAY121
Chugai Pharmaceutical
Phase 1
144
California, Maryland, New York, North Carolina, Ohio, Oregon, Pennsylvania, Texas
2024-08-19
Active, closed
A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
NCT06508658Diffuse Large B-Cell Lymphoma
DrugsEpcoritamab·Lenalidomide·Rituximab·Oxaliplatin
Genmab
Phase 3
379
California, Colorado, Georgia, Illinois, Indiana, Kansas, Kentucky, Maryland
2024-08-13
Recruiting
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
NCT06467357Biliary Tract Cancer
DrugsRilvegostomig·Trastuzumab deruxtecan·Durvalumab·Gemcitabine
AstraZeneca
Phase 3
620
Arizona, California, District of Columbia, Florida, Georgia, Idaho, Illinois, Maryland
2024-08-12
Active, closed
A Study to Evaluate the Effect of Venetoclax on Participants Receiving a Covalent Bruton's Tyrosine Kinase Inhibitor (cBTKi) for First-line Chronic Lymphocytic Leukemia (1L CLL) to Achieve Deep Durable Remissions to Allow Off-treatment Period
NCT06524375Chronic Lymphocytic Leukemia
DrugVenetoclax
Genentech, Inc.
Phase 2
118
Arkansas, Colorado, Florida, Indiana, Iowa, Maryland, Massachusetts, Nebraska
2024-08-09
Active, closed
Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib
NCT06531109Alopecia Areata
DrugRitlecitinib
Pfizer
Observational
450
Alabama, California, Florida, Iowa, Maryland, Massachusetts, Michigan, Minnesota
2024-08-07
Recruiting
Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
NCT06380751Advanced Breast Cancer
DrugsSaruparib·Camizestrant·Exemestane·Anastrozole
AstraZeneca
Phase 3
788
Arizona, California, Colorado, Florida, Illinois, Indiana, Kentucky, Maryland
2024-08-01
Recruiting
A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)
NCT06163534Head and Neck Squamous Cell Carcinoma
Tempus AI
Observational
500
California, Florida, Georgia, Illinois, Kansas, Maryland, Massachusetts, Michigan
2024-08-01
Recruiting
Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC
NCT05733598Hepatocellular Carcinoma, Biliary Tract Cancer
DrugsRP2·Tecentriq·Avastin·Atezolizumab
Replimune, Inc.
Phase 2
60
California, Florida, Maryland, New York, Pennsylvania, Tennessee, Texas
2024-08-01
Recruiting
VTP-1000 in Adults With Celiac Disease
NCT06310291Celiac Disease
Barinthus Biotherapeutics
Phase EARLY_PHASE1
45
California, Colorado, Florida, Maryland, Michigan, Minnesota, New York, North Carolina
2024-08-01
Active, closed
A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.
NCT06517758Generalized Myasthenia Gravis
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
146
Arizona, California, Georgia, Illinois, Maryland, Massachusetts, Michigan, North Carolina
2024-07-31
Active, closed
A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression
NCT06365853Recurrent Ovarian Cancer, Folate Receptor-Alpha Positive
DrugsMIRV·Mirvetuximab Soravtansine
AbbVie
Phase 2
108
California, Kentucky, Maryland, Missouri, Nevada, New Jersey, New York, North Carolina
2024-07-29
Recruiting
The Study of 177Lu-TLX591 Plus SOC Versus SOC Alone in Patients With mCRPC (ProstACT Global)
NCT06520345Metastatic Castration-resistant Prostate Cancer
DrugsAbiraterone·Enzalutamide·Docetaxel
Telix Pharmaceuticals (Innovations) Pty Limited
Phase 3
520
California, Florida, Maryland, Nebraska, New York, Ohio, Oregon, Utah
2024-07-26
Active, closed
A Phase 3b, Single-Arm Study of Aflibercept 8 mg Dosed Every 4 Weeks in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME)
NCT06491914Neovascular Age-Related Macular Degeneration, Diabetic Macular Edema
DrugAflibercept
Regeneron Pharmaceuticals
Phase 3
1,126
California, Colorado, Connecticut, Florida, Georgia, Hawaii, Illinois, Maryland
2024-07-24
Active, closed
Study of Plozasiran in Adults With Severe Hypertriglyceridemia
NCT06347016Severe Hypertriglyceridemia
DrugPlozasiran
Arrowhead Pharmaceuticals
Phase 3
311
Alabama, California, Florida, Georgia, Indiana, Kansas, Louisiana, Maryland
2024-07-23
Active, closed
Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia
NCT06347003Severe Hypertriglyceridemia
DrugPlozasiran
Arrowhead Pharmaceuticals
Phase 3
446
California, Colorado, Florida, Georgia, Illinois, Louisiana, Maryland, Michigan
2024-07-22
Recruiting
A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)
NCT06521554Locally Advanced Solid Tumor, Metastatic Solid Tumor
Nuvalent Inc.
Phase 1
200
California, Colorado, District of Columbia, Florida, Maryland, Massachusetts, Michigan, Missouri
2024-07-18
Recruiting
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
NCT06481306Anemia, Sickle Cell, Healthy Volunteers
DrugsFamotidine·Pantoprazole
Bristol-Myers Squibb
Phase 1/2
224
Alabama, California, Connecticut, Georgia, Illinois, Kansas, Maryland, Massachusetts
2024-07-17
Recruiting
Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL
NCT05952024Diffuse Large B-Cell Lymphoma
DrugsAcalabrutinib·Rituximab
AstraZeneca
Phase 2
80
California, Connecticut, Florida, Iowa, Kentucky, Maryland, Michigan, South Dakota
2024-07-16
Recruiting
Zopa Retreatment and Vector Shedding in Adults With RRP
NCT06538480Recurrent Respiratory Papillomatosis, Papillomavirus Infection, Papillomaviridae
Precigen, Inc
Phase 4
30
Georgia, Maryland, Ohio
2024-07-11
Active, closed
Evaluation of Improved Onboard Patient Imaging
NCT06187103Head and Neck Cancer, Breast Cancer, Upper Gastrointestinal Cancer, Lung Cancer
Varian, a Siemens Healthineers Company
Observational
40
Maryland
2024-07-10
Recruiting
A Pilot Study of a Commercially-available Oil Rinse Product (PerioPull™) on Markers of Dental Health
NCT06363721Oral Health
Designs for Health
Not applicable
18
Maryland
2024-07-10
Active, closed
A Study to Assess the Effects of Dexpramipexole in Participants With Eosinophilic COPD
NCT06533553Chronic Obstructive Pulmonary Disease
DrugDexpramipexole Dihydrochloride
Areteia Therapeutics
Phase 2
30
Arkansas, California, Florida, Illinois, Indiana, Iowa, Maryland, Michigan
2024-07-09
Recruiting
Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen
NCT06127407Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen
DrugIvosidenib
Servier Bio-Innovation LLC
Phase 3
136
California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa, Maryland
2024-07-09
Active, closed
A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)
NCT06455098Atrial Fibrillation
Biosense Webster, Inc.
Not applicable
354
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Maryland
2024-06-28
Recruiting
A Study to Evaluate the Safety and Efficacy of a Single Dose of RABI-767 in Participants With Acute Pancreatitis
NCT06080789Acute Pancreatitis
Panafina, Inc.
Phase 2
36
Arkansas, California, Colorado, Florida, Illinois, Indiana, Maryland, Michigan
2024-06-28
Active, closed
Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)
NCT06331312Polymyalgia Rheumatica
DrugSecukinumab
Novartis Pharmaceuticals
Phase 3
162
Arizona, California, Florida, Maryland, Michigan, New Hampshire, Ohio, Texas
2024-06-28
Recruiting
Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis
NCT06465810Transthyretin Amyloidosis, ATTR-CM, ATTRv-PN, ATTR
AstraZeneca
Observational
1,850
California, Connecticut, District of Columbia, Illinois, Indiana, Maryland, Massachusetts, Minnesota
2024-06-25
Recruiting
Enzalutamide Implants (Enolen) in Patients With Prostate Cancer
NCT06257693Prostate Adenocarcinoma
DrugEnzalutamide
Alessa Therapeutics Inc.
Phase 1
45
California, Illinois, Louisiana, Maryland, Oregon, South Carolina, Virginia, Wisconsin
2024-06-21
Recruiting
Atrial Flutter Ablation in the iCMR
NCT05904548Atrial Flutter Typical
Imricor Medical Systems
Not applicable
91
Maryland, Virginia
2024-06-20
Recruiting
Prescreening Study to Identify Potential Stargardt Participants for ACDN-01 Clinical Trials (STARPATH)
NCT06445322Stargardt Disease, Stargardt Disease 1, Cone Rod Dystrophy, Juvenile Macular Degeneration
Ascidian Therapeutics, Inc
Observational
50
California, Florida, Maryland, Massachusetts, Michigan, Ohio, Texas
2024-06-20
Recruiting
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
NCT06063850Mesial Temporal Lobe Epilepsy
UniQure Biopharma B.V.
Phase 1/2
12
Alabama, Arizona, California, Florida, Kansas, Maryland, Massachusetts, Michigan
2024-06-12
Recruiting
Study of ALTO-101 in Patients With Schizophrenia
NCT06502964Schizophrenia, Cognitive Impairment
Alto Neuroscience
Phase 2
82
California, Florida, Georgia, Illinois, Maryland, Massachusetts, New York
2024-06-11
Recruiting
Study to Evaluate ACDN-01 in ABCA4-related Stargardt Retinopathy (STELLAR)
NCT06467344Stargardt Disease, Cone Rod Dystrophy, Juvenile Macular Degeneration, Stargardt Disease 1
Ascidian Therapeutics, Inc
Phase 1/2
15
California, Florida, Maryland, Massachusetts, Michigan, Ohio, Oregon, Texas
2024-06-11
Recruiting
Transdermal Compress IDE Study
NCT06134167Prosthesis and Implants
Balmoral Medical company
Not applicable
100
California, Colorado, Illinois, Maryland, New York, Ohio, Pennsylvania
2024-06-11
Recruiting
MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion
NCT05037968Degenerative Disc Disease, Spine Fusion, Leg Pain and/or Back Pain
Kuros Biosurgery AG
Not applicable
100
Connecticut, Illinois, Maryland, Michigan, North Carolina, Ohio, Utah, Virginia
2024-06-10
Recruiting
Prospective Clinical Assessment Study in Children With Hypochondroplasia
NCT06410976Hypochondroplasia
QED Therapeutics, a BridgeBio company
Observational
150
California, Colorado, District of Columbia, Maryland, Missouri, Ohio, Tennessee, Wisconsin
2024-06-05
Recruiting
Gleolan for Visualization of Newly Diagnosed or Recurrent Ovarian Cancer (OVA-302)
NCT05804370Ovarian Cancer
DrugGleolan
NX Development Corp
Phase 3
170
Arizona, Florida, Maryland, Minnesota, New York, Ohio, Pennsylvania, Virginia
2024-05-30
Active, closed
ReNEW:Phase 3 Study of Efficacy, Safety & Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects With Dry Age-Related Macular Degeneration (Dry AMD)
NCT06373731Age Related Macular Degeneration (ARMD)
DrugElamipretide
Stealth BioTherapeutics Inc.
Phase 3
313
Arizona, California, Colorado, Connecticut, Florida, Illinois, Indiana, Maryland
2024-05-30
Recruiting
Dose Escalation and Expansion Study to Evaluate the Safety, PK, PD and Efficacy of ZE46-0134 in Adults With FLT3 Mutated or Spliceosome Mutated Relapsed or Refractory Acute Myeloid Leukemia
NCT06366789AML With Gene Mutations
Lomond Therapeutics Holdings, Inc.
Phase 1
150
California, Georgia, Illinois, Kansas, Maryland, New York, North Carolina, Ohio
2024-05-29
Recruiting
A Study of Pitolisant in Patients With Prader-Willi Syndrome
NCT06366464Prader-Willi Syndrome
DrugPitolisant
Harmony Biosciences Management, Inc.
Phase 3
134
California, Colorado, Delaware, Georgia, Illinois, Indiana, Maryland, Minnesota
2024-05-28
Recruiting
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
NCT06445062Colorectal Cancer, CRC, Pancreatic Ductal Adenocarcinoma, PDAC
DrugsRMC-9805·MFOLFIRINOX·MFOLFOX6·Folfiri
Revolution Medicines, Inc.
Phase 1/2
1,130
Arizona, California, Colorado, Connecticut, Florida, Kansas, Maryland, Massachusetts
2024-05-24
Recruiting
Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer
NCT06343402Non-small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer, NSCLC, KRAS G12C
DrugsBBO-10203·Pembrolizumab
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
Phase 1
350
Alabama, California, Colorado, Connecticut, Illinois, Kansas, Maryland, Michigan
2024-05-22
Recruiting
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
NCT06203210Small Cell Lung Cancer
DrugsAmrubicin·Ifinatamab Deruxtecan·Lurbinectedin·Topotecan
Daiichi Sankyo
Phase 3
540
Arkansas, California, Florida, Illinois, Kentucky, Maryland, Massachusetts, Michigan
2024-05-21
Recruiting
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
NCT06133972Systemic Lupus Erythematosus
DrugIanalumab
Novartis Pharmaceuticals
Phase 3
550
Alabama, California, Colorado, Florida, Georgia, Illinois, Louisiana, Maryland
2024-05-21
Recruiting
Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)
NCT06353386Prostatic Neoplasms, Castration-Resistant
DrugsFludrocortisone acetate·Opevesostat·Cabazitaxel·Taxotere
Merck Sharp & Dohme LLC
Phase 1/2
220
California, Florida, Maryland, New Jersey, Ohio, Wisconsin
2024-05-20
Recruiting
Lentiviral Gene Therapy (Zamtocabtagene Autoleucel) LTFU
NCT06116110Non Hodgkin Lymphoma, Refractory Diffuse Large B Cell Lymphoma (DLBCL), Relapsed Diffuse Large B Cell Lymphoma, High Grade B-cell Lymphoma
Miltenyi Biomedicine GmbH
Observational
150
Arizona, California, Connecticut, Illinois, Kansas, Maryland, Massachusetts, North Carolina
2024-05-15
Active, closed
A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy
NCT06321302Diabetic Retinopathy
Boehringer Ingelheim
Phase 2
190
Arizona, California, Colorado, Connecticut, Florida, Hawaii, Maine, Maryland
2024-05-15
Active, closed
Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP
NCT06079359Hypophosphatasia
DrugALXN1850
Alexion Pharmaceuticals, Inc.
Phase 3
30
Maryland, Missouri, North Carolina
2024-05-14
Active, closed
The ACES Study for Aseptic Pleural Effusion
NCT06210685Pleural Effusion
Pleural Dynamics, Inc.
Not applicable
25
Florida, Maryland, North Carolina, Tennessee
2024-05-12
Recruiting
A Dose Escalation and Expansion Study of GIGA-564 in Participants With Locally Advanced or Metastatic Solid Tumor Malignancies
NCT06258304Advanced or Metastatic Solid Tumor Malignancies
GigaGen, Inc.
Phase 1
60
Maryland
2024-05-08
Active, closed
Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes
NCT06267391Type 2 Diabetes Mellitus, Type2diabetes, Diabetes Mellitus, Type 2, Diabetes
Endogenex, Inc.
Not applicable
350
Alabama, California, Florida, Illinois, Iowa, Maryland, Minnesota, New Jersey
2024-05-01
By invitation
A Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE)
NCT06431893Homocystinuria
DrugPegtibatinase
Travere Therapeutics, Inc.
Phase 3
100
Arizona, Connecticut, Georgia, Illinois, Maine, Maryland, New York, North Carolina
2024-04-30
Recruiting
Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT06350097Non-small Cell Lung Cancer
DrugsDato-DXd·Osimertinib
AstraZeneca
Phase 3
582
California, Connecticut, District of Columbia, Florida, Hawaii, Illinois, Indiana, Maryland
2024-04-29
Recruiting
A Study for Participants Previously Treated With Century Therapeutics Cellular Therapy Product
NCT05768269Hematological Malignancy, Solid Tumor Malignancy
Century Therapeutics, Inc.
Observational
375
Arizona, California, Maryland, Michigan, North Carolina, Ohio, Washington
2024-04-29
Active, closed
A Study Evaluating APG777 in Atopic Dermatitis
NCT06395948Atopic Dermatitis
DrugAPG777
Apogee Therapeutics, Inc.
Phase 2
470
California, Connecticut, Florida, Georgia, Illinois, Indiana, Kentucky, Maryland
2024-04-29
Active, closed
Study Evaluating SC291 in Subjects With Severe r/r B-cell Mediated Autoimmune Diseases (GLEAM)
NCT06294236Lupus Erythematosus, Systemic Lupus Erythematosus, SLE (Systemic Lupus), Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
DrugsSC291·Fludarabine·Cyclophosphamide
Sana Biotechnology
Phase 1
7
Colorado, Georgia, Maryland, Massachusetts, Washington
2024-04-29
Recruiting
A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer
NCT06385080Squamous Cell Carcinoma of Head and Neck
DrugsAmivantamab·Paraplatin·Taxol·Keytruda
Janssen Research & Development, LLC
Phase 1/2
287
California, Colorado, Connecticut, Illinois, Maryland, Massachusetts, Michigan, Missouri
2024-04-22
Recruiting
A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia
NCT05980806Myelofibrosis, Moderate Thrombocytopenia, Mild Thrombocytopenia
DrugsMomelotinib·Pacritinib·Selinexor·Ruxolitinib
Karyopharm Therapeutics Inc
Phase 2
58
California, Maryland, New York, North Carolina, Ohio, Texas, Utah
2024-04-22
Active, closed
Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta
NCT05972551Osteogenesis Imperfecta
DrugRomosozumab
Amgen
Phase 3
111
Alabama, Arizona, California, Delaware, Florida, Georgia, Indiana, Maryland
2024-04-22
Recruiting
Phase 1a/1b First-in-Human Study of BG-C9074 Alone and in Combination With Other Anticancer Therapies in Patients With Advanced Solid Tumors
NCT06233942Advanced Solid Tumor
DrugsTislelizumab·Bevacizumab
BeOne Medicines
Phase 1
308
California, Colorado, Florida, Maryland, Ohio
2024-04-12
Recruiting
To Assess the Safety and Efficacy of SP-002 with Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma
NCT06344052Basal Cell Carcinoma
DrugVismodegib
Stamford Pharmaceuticals, Inc.
Phase 2
80
Arizona, Florida, Maryland, Missouri, New York, Texas
2024-04-09
Active, closed
A Study of Sovilnesib in Subjects With Ovarian Cancer
NCT06084416High Grade Serous Adenocarcinoma of Ovary, Fallopian Tube Cancer, Primary Peritoneal Carcinoma, Chromosomal Instability
Volastra Therapeutics, Inc.
Phase 1
120
Alabama, Arkansas, California, Georgia, Maryland, Massachusetts, Michigan, New York
2024-04-04
Active, closed
A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic NSCLC Patients With Non-squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS
NCT06008093Carcinoma, Non-Small-Cell Lung
DrugsTremelimumab·Durvalumab·Pemetrexed·Cisplatin
AstraZeneca
Phase 2
103
California, District of Columbia, Florida, Georgia, Hawaii, Illinois, Maryland, Massachusetts
2024-04-04
Active, closed
Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa
NCT06079372Hypophosphatasia
DrugsAsfotase alfa·ALXN1850
Alexion Pharmaceuticals, Inc.
Phase 3
43
Connecticut, Maryland, Minnesota, Missouri, North Carolina, Tennessee
2024-04-02
Active, closed
RRx-001 for Reducing Oral Mucositis in Patients Receiving Chemotherapy and Radiation for Head and Neck Cancer
NCT05966194Oral Mucositis
DrugsRRx-001·Cisplatin
EpicentRx, Inc.
Phase 2
216
Arizona, Florida, Illinois, Indiana, Louisiana, Maryland, Michigan, Nevada
2024-04-02
Active, closed
A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation
NCT06200207Heart Failure, Systemic Inflammation
DrugZiltivekimab
Novo Nordisk A/S
Phase 3
673
Alabama, Arkansas, California, Florida, Georgia, Illinois, Kentucky, Maryland
2024-04-01
Recruiting
An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene
NCT06435000Stargardt, Stargardt's Disease, Stargardt Disease, STGD1
Splice Bio
Observational
75
California, Colorado, Florida, Georgia, Maryland, Massachusetts, Michigan, New York
2024-03-29
Active, closed
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis
NCT06254950Ulcerative Colitis
DrugZasocitinib
Takeda
Phase 2
213
California, Florida, Georgia, Kentucky, Maryland, Nevada, Rhode Island, South Carolina
2024-03-29
Recruiting
Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC
NCT06228924Arrhythmogenic Right Ventricular Cardiomyopathy
Tenaya Therapeutics
Phase 1
15
California, Colorado, Maryland, Massachusetts, Minnesota, New York, Ohio
2024-03-26
Recruiting
Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera
NCT06093672Polycythemia Vera
DrugHydroxyurea
Italfarmaco
Phase 3
220
Alabama, California, Colorado, Maryland, New York, North Carolina, Ohio, Oregon
2024-03-26
Recruiting
Efficacy and Safety Study of OATD-01 in Patients With Active Pulmonary Sarcoidosis
NCT06205121Pulmonary Sarcoidosis
Molecure S.A.
Phase 2
96
Alabama, Kansas, Maryland, Minnesota, Ohio, Pennsylvania, South Carolina
2024-03-21
Active, closed
REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study
NCT06041386Asthma
DrugMepolizumab
GlaxoSmithKline
Phase 4
336
California, Colorado, Connecticut, Florida, Georgia, Kentucky, Louisiana, Maryland
2024-03-20
Active, closed
Microfragmented Adipose Tissue Compared to Saline Injection for the Treatment of Knee Osteoarthritis
NCT06121882Knee Osteoarthritis, Osteo Arthritis Knee
Lipogems International spa
Phase 3
173
Arizona, California, Florida, Georgia, Louisiana, Maryland, Minnesota, Oklahoma
2024-03-15
Recruiting
An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants
NCT05835310Systemic Lupus Erythematosus
DrugAnifrolumab
AstraZeneca
Phase 3
100
Arizona, California, District of Columbia, Illinois, Louisiana, Maryland, Minnesota, New York
2024-03-14
Active, closed
A Clinical Trial Evaluating the Safety and Efficacy of a Single Subretinal Injection of AGTC-501 in Participants With XLRP
NCT04850118X-Linked Retinitis Pigmentosa
DrugAGTC-501
Beacon Therapeutics
Phase 2/3
85
Arizona, California, Florida, Indiana, Maryland, Massachusetts, Minnesota, North Carolina
2024-03-14
Active, closed
A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2)
NCT06220604Plaque Psoriasis
DrugsIcotrokinra·Deucravacitinib
Janssen Research & Development, LLC
Phase 3
731
Arizona, California, Florida, Georgia, Illinois, Kentucky, Maryland, Massachusetts
2024-03-09
Active, closed
FPI-2265 (225Ac-PSMA-I&T) for Patients With PSMA-Positive Metastatic Castration-Resistant Prostate Cancer (mCRPC)
NCT06402331Metastatic Castration-resistant Prostate Cancer
DrugFPI-2265
Fusion Pharmaceuticals Inc.
Phase 2
110
California, Florida, Iowa, Maryland, Michigan, Missouri, Nebraska, New Mexico
2024-03-05
Recruiting
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
NCT06233461Crohn's Disease
DrugZasocitinib
Takeda
Phase 2
268
California, Florida, Georgia, Iowa, Kansas, Kentucky, Maryland, Missouri
2024-03-05
Active, closed
Gene Therapy for ACM Due to a PKP2 Pathogenic Variant
NCT06109181Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
Lexeo Therapeutics
Phase 1/2
10
California, Maryland, Michigan, New York, South Carolina
2024-02-29
Recruiting
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
NCT06172478Advanced Solid Tumor, Melanoma, Head and Neck Cancer, Gastric Cancer
DrugPatritumab deruxtecan
Daiichi Sankyo
Phase 2
740
California, Connecticut, Florida, Illinois, Maryland, Minnesota, Missouri, New York
2024-02-26
Active, closed
RESTORE: An RCT to Evaluate the Efficacy of the Revi System
NCT06217328Urinary Urge Incontinence
BlueWind Medical
Not applicable
117
Arizona, California, Florida, Illinois, Louisiana, Maryland, Missouri, Nebraska
2024-02-24
Active, closed
SkinTE® for the Treatment of Wagner 1 Diabetic Foot Ulcers (COVER DFUS II)
NCT06140303Diabetic Foot
PolarityTE
Phase 3
100
Arizona, California, Florida, Maryland, Nevada, New York, Ohio, Texas
2024-02-22
Active, closed
A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer
NCT06012435Carcinoma, Non-Small-Cell Lung
DrugsSigvotatug vedotin·Docetaxel
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
762
Alaska, California, Colorado, Florida, Illinois, Maryland, Massachusetts, Minnesota
2024-02-21
Active, closed
A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)
NCT06215118Multiple Myeloma
DrugsIberdomide·Elranatamab
Pfizer
Phase 1
100
Florida, Georgia, Indiana, Maryland, Massachusetts, Nebraska, New Hampshire, New Jersey
2024-02-20
Active, closed
A Research Study to Look at Long-term Treatment With a Medicine Called NNC6019-0001 for People Who Have Heart Failure Due to Transthyretin Amyloidosis
NCT06260709Transthyretin Amyloid Cardiomyopathy (ATTR CM)
DrugNNC6019-0001
Novo Nordisk A/S
Phase 2
80
Arizona, California, Florida, Illinois, Maryland, Minnesota
2024-02-20
Active, closed
PYLARIFY® PET/CT or PET/MRI in Men With Favorable Intermediate Risk (FIR) Prostate Cancer
NCT06074510Prostate Cancer
DrugPylarify
Lantheus Medical Imaging
Phase 4
274
Alabama, California, Georgia, Iowa, Maryland, Massachusetts, Michigan, Missouri
2024-02-08
Recruiting
A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer
NCT06095505Small Cell Lung Cancer
DrugAlisertib
Puma Biotechnology, Inc.
Phase 2
120
Alabama, California, Colorado, District of Columbia, Florida, Illinois, Indiana, Maryland
2024-02-08
Recruiting
A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes
NCT06196203Higher-risk Myelodysplastic Syndromes
DrugsLigufalimab·Azacitidine
Akeso
Phase 2
90
California, Colorado, Connecticut, Florida, Maryland, Missouri, New York, North Carolina
2024-02-07
Recruiting
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM
NCT05902169Glioblastoma, Recurrent Glioblastoma, GBM
DrugsLomustine·Temodal·Temozolomide·Carboplatin
CarThera
Phase 3
560
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Maryland
2024-01-29
Active, closed
Safety, PK and PD Relationships of RLS-0071 in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
NCT06175065Acute Exacerbation of Chronic Obstructive Pulmonary Disease
DrugRLS-0071
ReAlta Life Sciences, Inc.
Phase 2
24
Florida, Maryland, Nebraska, Pennsylvania
2024-01-25
Recruiting
An Open-Label Study of CTI-1601 in Subjects With Friedreich's Ataxia
NCT06447025Friedreich Ataxia
DrugNomlabofusp
Larimar Therapeutics, Inc.
Phase 2
85
California, Florida, Iowa, Maryland, New Jersey, Ohio, Pennsylvania
2024-01-25
Recruiting
A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM
NCT06976606Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
Lexeo Therapeutics
Observational
40
California, Maryland, Michigan, New York
2024-01-23
Active, closed
A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
NCT06143891Chronic Graft Versus Host Disease
DrugsBelumosudil·Prednisolone·Prednisone
Sanofi
Phase 3
260
Arkansas, California, Florida, Georgia, Illinois, Indiana, Kentucky, Maryland
2024-01-23
Recruiting
A Study of NPX887 for Participants With Solid Tumors Known to Express B7-H7/HHLA2
NCT06240728Metastatic Malignant Neoplasm
NextPoint Therapeutics, Inc.
Phase 1
144
Maryland, Massachusetts, New York, Texas, Virginia
2024-01-22
Active, closed
A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo
NCT06163326Vitiligo
DrugRitlecitinib
Pfizer
Phase 3
394
California, Florida, Indiana, Louisiana, Maryland, Michigan, New Mexico, New York
2024-01-19
Recruiting
Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors
NCT06171750Advanced Solid Tumor, Cutaneous Tumor, Subcutaneous Tumor, Malignant Solid Tumor
DrugsTolododekin alfa·Cemiplimab
Ankyra Therapeutics, Inc
Phase 1
97
Maryland, Massachusetts, Oregon, Pennsylvania
2024-01-19
Recruiting
A Study of AZD3470, a PRMT5 Inhibitor, Given as Monotherapy and in Combination in Patients With MTAP Deficient Advanced/Metastatic Solid Tumors
NCT06130553Advanced Solid Tumors That Are MTAP Deficient
DrugsAZD3470·Dato-DXd
AstraZeneca
Phase 1/2
334
California, Connecticut, Maryland, Oregon, Pennsylvania, Rhode Island, Virginia
2024-01-18
Active, closed
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD1705 in Participants With Dyslipidemia
NCT06238466Cardiovascular
AstraZeneca
Phase 1
98
California, Florida, Maryland, Texas
2024-01-16
Recruiting
Comparing Use of Incentive Spirometry With and Without Reminder
NCT06101030Post Operative
Tidal Medical Technologies
Observational
500
Maryland, Minnesota, New Jersey
2024-01-16
Active, closed
Study to Assess the Efficacy & Safety of KHK4951 in Patients With Diabetic Macular Edema
NCT06116916Diabetic Macular Edema (DME)
DrugsKHK4951·Aflibercept
Kyowa Kirin Co., Ltd.
Phase 2
150
Arizona, California, Colorado, Florida, Maryland, Nevada, New Jersey, New Mexico
2024-01-09
Recruiting
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
NCT06179160Solid Tumors
DrugsGEMNabP·INCB161734·INCA33890·Retifanlimab
Incyte Corporation
Phase 1
710
Arizona, California, Colorado, Florida, Maryland, Massachusetts, New Jersey, New York
2024-01-04
Active, closed
Pasireotide s.c. in Patients With Post-Bariatric Hypoglycaemia
NCT05928390Post-Bariatric Hypoglycemia
RECORDATI GROUP
Phase 2
93
California, Illinois, Louisiana, Maryland, Massachusetts, Minnesota, New York, Tennessee
2024-01-04
Active, closed
The HistoSonics Edison™ System for Treatment of Primary Solid Renal Tumors Using Histotripsy (#HOPE4KIDNEY)
NCT05820087Renal Cancer, Tumor, Solid, Kidney Cancer, Tumor
HistoSonics, Inc.
Not applicable
67
California, Connecticut, Florida, Maryland, Massachusetts, New York, Ohio, Texas
2024-01-04
Recruiting
Pegtibatinase as a Treatment for Participants With Classical Homocystinuria (HCU) Receiving Standard of Care Treatment
NCT06247085Homocystinuria
DrugPegtibatinase
Travere Therapeutics, Inc.
Phase 3
70
Arizona, Connecticut, Georgia, Illinois, Maine, Maryland, New York, North Carolina
2023-12-28
Recruiting
A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
NCT05912517Hemolytic Disease of the Fetus and Newborn
DrugNipocalimab
Janssen Research & Development, LLC
Phase 3
120
California, Colorado, Florida, Illinois, Indiana, Iowa, Kentucky, Maryland
2023-12-20
Recruiting
RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy
NCT06154252Idiopathic Inflammatory Myopathy, Dermatomyositis, Anti-Synthetase Syndrome, Immune-Mediated Necrotizing Myopathy
Cabaletta Bio
Phase 2/3
74
California, Colorado, Florida, Georgia, Illinois, Kansas, Maryland, Massachusetts
2023-12-20
Recruiting
Contraceptive Efficacy Study of Ovaprene
NCT06127199Contraception
Daré Bioscience, Inc.
Not applicable
656
Arizona, California, Colorado, Georgia, Hawaii, Louisiana, Maryland, Massachusetts
2023-12-19
Active, closed
Clinical Evaluation of the i-STAT ACTpro Cartridge in an Adult Population
NCT07382076Activated Clotting Time
Abbott Point of Care
Observational
500
Arizona, California, District of Columbia, Kentucky, Maryland, Minnesota, Missouri, New York
2023-12-15
Active, closed
Study of Lenacapavir and Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF) for Prevention of HIV in People Who Inject Drugs (HPTN 103)
NCT06101342Pre-Exposure Prophylaxis of HIV Infection
DrugsEmtricitabine/tenofovir disoproxil fumarate·F/TDF·Lenacapavir
Gilead Sciences
Phase 2
181
California, Florida, Maryland, New Jersey, New York, Pennsylvania, Texas, West Virginia
2023-12-13
Active, closed
A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib
NCT05734105GIST
DrugsRipretinib·Sunitinib
Deciphera Pharmaceuticals, LLC
Phase 3
54
California, Connecticut, Florida, Maryland, Massachusetts, Minnesota, New York, Ohio
2023-12-13
Recruiting
A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma
NCT06091865Diffuse Large B-cell Lymphoma (DLBCL)
DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan
Regeneron Pharmaceuticals
Phase 3
904
Arizona, California, Florida, Indiana, Kentucky, Maryland, Massachusetts, Michigan
2023-12-13
Active, closed
ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC
NCT05682443Metastatic Castration-resistant Prostate Cancer
DrugsLutetium Lu-177 vipivotide tetraxetan·Gotistobart
OncoC4, Inc.
Phase 1/2
148
California, Colorado, Florida, Georgia, Maryland, Massachusetts, Mississippi, Nebraska
2023-12-11
Recruiting
Zenith® Fenestrated+ Clinical Study
NCT04875429Aortic Aneurysm, Abdominal, Juxtarenal Aortic Aneurysm, Extent IV Thoracoabdominal, Pararenal Aneurysm
Cook Research Incorporated
Not applicable
105
Alabama, California, District of Columbia, Florida, Georgia, Illinois, Indiana, Maryland
2023-12-08
Recruiting
A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms
NCT06034002Myeloproliferative Neoplasms
DrugsINCA033989·Ruxolitinib
Incyte Corporation
Phase 1
290
California, Florida, Kansas, Maryland, Massachusetts, Missouri, New York, North Carolina
2023-12-04
Active, closed
JuggerKnot With Broadband PMCF Study
NCT05762588Shoulder Injuries, Hip Injuries, Foot Injury, Ankle Injuries
Riverpoint Medical
Observational
30
Maryland
2023-11-30
Recruiting
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
NCT05934487Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure
Endotronix, Inc.
Not applicable
1,750
Arizona, California, Florida, Georgia, Illinois, Indiana, Kansas, Maryland
2023-11-29
Active, closed
Safety and Efficacy of the VERTICA® RF Device for the Treatment of ED
NCT06167733Erectile Dysfunction
OHH-MED Medical Ltd
Not applicable
201
California, Florida, Maryland, Ohio, Texas
2023-11-29
Recruiting
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening
NCT06122077Lung Cancer Diagnosis
Freenome Holdings Inc.
Observational
20,000
California, Connecticut, Florida, Georgia, Illinois, Kansas, Maryland, Massachusetts
2023-11-28
Active, closed
An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery
NCT06117891Unresectable Hepatocellular Carcinoma
DrugsTremelimumab·Atezolizumab·Durvalumab·Bevacizumab
Bayer
Observational
300
Maryland, Michigan, New York, Ohio, Pennsylvania
2023-11-27
Active, closed
A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V2)
NCT06113471NonSegmental Vitiligo
DrugPovorcitinib
Incyte Corporation
Phase 3
450
Alabama, California, Florida, Georgia, Illinois, Indiana, Louisiana, Maryland
2023-11-27
Recruiting
A Multicenter Multinational Observational Study of Children With Hypochondroplasia
NCT06212947Hypochondroplasia
BioMarin Pharmaceutical
Observational
400
Arizona, California, Delaware, District of Columbia, Illinois, Maryland, Massachusetts, Minnesota
2023-11-27
Recruiting
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
NCT05172973Aortic Valve Insufficiency, Aortic Valve Stenosis
Edwards Lifesciences
Not applicable
200
California, Colorado, Florida, Georgia, Illinois, Kansas, Maryland, Massachusetts
2023-11-22
Active, closed
SELF-CERV Pivotal Study: SELF-Collection for CERVical Cancer Screening
NCT06120205Hpv, HPV 16 Infection, HPV Infection, High Risk HPV
Teal Health, Inc.
Not applicable
870
Alabama, California, Colorado, Connecticut, Louisiana, Maryland, Massachusetts, Missouri
2023-11-20
Recruiting
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
NCT06131840Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Stomach Neoplasms, Pancreatic Ductal Adenocarcinoma
DrugsLeucovorin·Adrucil·Oxaliplatin·Bevacizumab
Seagen, a wholly owned subsidiary of Pfizer
Phase 1
914
Arizona, California, Colorado, Florida, Maryland, Massachusetts, Michigan, Minnesota
2023-11-20
Recruiting
uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto
NCT05874921Urothelial Carcinoma, Urothelial Carcinoma Recurrent, Urothelial Carcinoma Ureter, Urothelial Carcinoma Ureter Recurrent
DrugMitomycin C
UroGen Pharma Ltd.
Observational
450
California, Florida, Illinois, Indiana, Iowa, Maryland, Massachusetts, Michigan
2023-11-17
Active, closed
A Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Sclerosis Patients
NCT06292923Secondary Progressive Multiple Sclerosis
Tiziana Life Sciences LTD
Phase 2
54
Connecticut, Maryland, Massachusetts, New York, Pennsylvania
2023-11-15
Recruiting
ACP-204 in Adults With Alzheimer's Disease Psychosis
NCT06159673Alzheimer's Disease Psychosis
DrugACP-204
ACADIA Pharmaceuticals Inc.
Phase 2/3
1,074
Arizona, California, Florida, Illinois, Louisiana, Maryland, Michigan, Missouri
2023-11-14
Active, closed
Study of Multiple-Ascending-Dose Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis With or Without Extrapulmonary Manifestations
NCT05890729Pulmonary Sarcoidosis
Xentria, Inc.
Phase 1/2
32
Alabama, Colorado, Florida, Illinois, Iowa, Maryland, Michigan, Minnesota
2023-11-10
Active, closed
A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2
NCT06072183Stable Nonsegmental Vitiligo, Active Nonsegmental Vitiligo
DrugRitlecitinib
Pfizer
Phase 3
1,571
Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana, Maryland
2023-11-08
Active, closed
A Study to Estimate How Often Post-stroke Spasticity Occurs and to Provide a Standard Guideline on the Best Way to Monitor Its Development
NCT06055725Spasticity as Sequela of Stroke
Ipsen
Observational
1,057
California, Florida, Maryland, Massachusetts, Missouri, Nebraska, Nevada, North Carolina
2023-11-01
Recruiting
Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation
NCT05696626Metastatic Breast Cancer
DrugsAbemaciclib·Fulvestrant
LeonaBio
Phase 3
600
Arizona, California, Florida, Georgia, Kentucky, Maryland, Massachusetts, Michigan
2023-10-31
Active, closed
A Randomized, Double-blind 2-arm, Followed by an Open-label 1-arm, NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.
NCT05985915Sjogrens Syndrome
DrugIanalumab
Novartis Pharmaceuticals
Phase 3
612
California, Florida, Georgia, Illinois, Kansas, Louisiana, Maryland, Massachusetts
2023-10-27
By invitation
Long-Term Safety and Efficacy of Tegoprubart in Kidney Transplant Recipients
NCT06126380Kidney Transplant Rejection
DrugsTegoprubart·Tacrolimus
Eledon Pharmaceuticals
Phase 2
132
California, District of Columbia, Florida, Georgia, Illinois, Kansas, Louisiana, Maryland
2023-10-25
Active, closed
A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.
NCT05984277Metastatic Non-small Cell Lung Cancer
DrugsVolrustomig·Pemetrexed·Paclitaxel·Carboplatin
AstraZeneca
Phase 3
895
Arkansas, California, Colorado, Florida, Indiana, Iowa, Kentucky, Maryland
2023-10-24
Active, closed
ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions
NCT05949684Myelodysplastic Syndromes
DrugsEpoetin Alfa·Reblozyl·Luspatercept
Bristol-Myers Squibb
Phase 3
402
California, Connecticut, Florida, Hawaii, Illinois, Indiana, Louisiana, Maryland
2023-10-24
Active, closed
A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia
NCT05952037Waldenstrom Macroglobulinemia, Waldenstrom's Macroglobulinemia Recurrent, Waldenstrom's Macroglobulinemia Refractory
DrugsSonrotoclax·Zanubrutinib
BeOne Medicines
Phase 2
114
California, Colorado, District of Columbia, Florida, Illinois, Iowa, Maryland, Massachusetts
2023-10-23
Recruiting
An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant
NCT05106387Chronic Kidney Disease (CKD)
DrugVonsetamig
Regeneron Pharmaceuticals
Observational
20
California, Connecticut, Illinois, Maryland, Minnesota, New York, Pennsylvania
2023-10-19
Recruiting
A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer
NCT05902988Advanced Solid Tumor, High Grade Serous Adenocarcinoma of Ovary, Squamous Non-small-cell Lung Cancer, Triple Negative Breast Cancer
Volastra Therapeutics, Inc.
Phase 1/2
200
California, Colorado, Connecticut, Illinois, Indiana, Maryland, Michigan, New York
2023-10-18
Active, closed
A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
NCT06075667Obesity, Overweight
DrugTirzepatide
Eli Lilly and Company
Phase 3
160
Georgia, Idaho, Kansas, Louisiana, Maryland, Minnesota, Missouri, Ohio
2023-10-16
Recruiting
DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With Small Cell Lung Cancer or Other Neuroendocrine Cancers
NCT05882058Small Cell Lung Carcinoma, Neuroendocrine Neoplasms, Extra-pulmonary Neuroendocrine Carcinoma
DrugObrixtamig
Boehringer Ingelheim
Phase 2
204
Alabama, Arizona, California, Florida, Indiana, Kansas, Kentucky, Maryland
2023-10-13
Active, closed
A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome
NCT05804669Cushing Syndrome, Cushing Disease, Ectopic ACTH Syndrome
DrugAtumelnant
Crinetics Pharmaceuticals Inc.
Phase 1/2
19
Maryland
2023-10-12
Recruiting
A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction
NCT06082037Lung Transplant Rejection
DrugsBelumosudil·Azithromycin
Sanofi
Phase 3
180
Alabama, Arizona, California, Florida, Georgia, Illinois, Iowa, Maryland
2023-10-10
Active, closed
XVIVO Heart Perfusion System (XHPS) With Supplemented XVIVO Heart Solution (SXHS)
NCT05881278Heart Failure, Transplant; Failure, Heart
XVIVO Perfusion
Not applicable
141
California, Georgia, Illinois, Maryland, Missouri, Nebraska, New York, North Carolina
2023-10-10
Recruiting
Metastatic Castrate-Resistant Prostate Cancer Subjects Treated With PROVENGE® + One Infusion of Sipuleucel-T
NCT06134232Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Dendreon
Phase 2
400
Arizona, California, Colorado, Florida, Illinois, Indiana, Maryland, Michigan
2023-10-02
Active, closed
A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Episodic Migraine in Adults
NCT06047457Episodic Migraine
DrugsDysport·Botulinum toxin type A
Ipsen
Phase 3
751
Alabama, Arizona, California, Connecticut, Florida, Illinois, Indiana, Maryland
2023-09-29
Active, closed
A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration
NCT06161584Geographic Atrophy
DrugsSyfovre·Pegcetacoplan
Apellis Pharmaceuticals, Inc.
Observational
300
California, Colorado, Florida, Georgia, Illinois, Maryland, Minnesota, New Jersey
2023-09-28
By invitation
A Long-term Follow-up Study of Participants Who Received Delandistrogene Moxeparvovec (SRP-9001) in a Previous Clinical Study
NCT05967351Duchenne Muscular Dystrophy
Sarepta Therapeutics, Inc.
Phase 3
400
Arkansas, California, Colorado, Florida, Illinois, Iowa, Maryland, Massachusetts
2023-09-27
Recruiting
Targeted Alpha-Particle Therapy for Advanced Somatostatin Receptor Type 2 (SSTR2) Positive Tumors
NCT05636618Neuroendocrine Tumors Unresectable, Neuroendocrine Tumor Metastatic, Gastroenteropancreatic Neuroendocrine Tumor, Bronchial Neuroendocrine Tumor
Perspective Therapeutics
Phase 1/2
300
Florida, Illinois, Iowa, Kentucky, Maryland, Michigan, Minnesota, Missouri
2023-09-27
Active, closed
A Long-term Study of STAR-0215 in Participants With Hereditary Angioedema
NCT06007677Hereditary Angioedema
DrugNavenibart
Astria Therapeutics, Inc.
Phase 2
56
Alabama, Arizona, Arkansas, California, Maryland, Massachusetts, Missouri, Ohio
2023-09-26
Recruiting
A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease
NCT05878717Systemic Sclerosis Associated Interstitial Lung Disease, Scleroderma, Systemic
DrugBelimumab
GlaxoSmithKline
Phase 2/3
300
Arizona, California, Colorado, District of Columbia, Florida, Illinois, Maryland, Michigan
2023-09-13
By invitation
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy
NCT05979441Myositis, Active Idiopathic Inflammatory Myopathy, Dermatomyositis, Polymyositis
DrugEfgartigimod PH20
argenx
Phase 3
240
Arizona, California, Connecticut, Florida, Georgia, Illinois, Maryland, New York
2023-09-12
Active, closed
A Community-Based Screening Program to Identify Participants at High Risk for Amyloid Pathology
NCT06043700Alzheimer's Disease
Eisai Limited
Observational
2,000
Florida, Maryland
2023-09-12
Active, closed
A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome
NCT05946941Sjögren's Syndrome
DrugDeucravacitinib
Bristol-Myers Squibb
Phase 3
774
California, Colorado, Florida, Georgia, Illinois, Kansas, Louisiana, Maryland
2023-09-11
Active, closed
Cryoablation for Monomorphic Ventricular Tachycardia
NCT05675865Sustained VT
Adagio Medical
Not applicable
206
Arizona, California, Maryland, Massachusetts, Michigan, New York, Ohio, Pennsylvania
2023-09-11
Recruiting
Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)
NCT05722938Community-acquired Pneumonia
Biotest
Phase 3
590
Alabama, Arizona, California, Georgia, Maryland, Massachusetts, Michigan, Missouri
2023-09-09
Recruiting
A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer
NCT05894239Metastatic Breast Cancer
DrugsPhesgo·Inavolisib
Hoffmann-La Roche
Phase 3
230
Arizona, California, District of Columbia, Maryland, Massachusetts, Michigan, Nevada, New Jersey
2023-09-08
Active, closed
To Compare the Efficacy and Safety of the ATEV With AVF in Female Patients With End-Stage Renal Disease Requiring Hemodialysis
NCT05908084End Stage Renal Disease (ESRD)
Humacyte, Inc.
Phase 3
121
Arizona, California, Colorado, Connecticut, Florida, Georgia, Indiana, Maryland
2023-09-07
Recruiting
Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06040541Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumors
DrugsRMC-9805·Cetuximab
Revolution Medicines, Inc.
Phase 1
604
California, Connecticut, Florida, Maryland, Massachusetts, New York, North Carolina, Ohio
2023-09-07
Recruiting
IKS03 in Patients With Advanced B Cell Non-Hodgkin Lymphomas
NCT05365659B-cell Non-Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, Follicular Lymphoma, Mantle Cell Lymphoma
Iksuda Therapeutics Ltd.
Phase 1
140
Maryland
2023-09-05
Recruiting
A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)
NCT05652686Small Cell Lung Cancer (SCLC), Large Cell Neuroendocrine Cancer (LCNEC), Neuroendocrine Prostate Cancer (NEPC), Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC)
DrugsLurbinectedin·Topotecan·Irinotecan·Etoposide
Phanes Therapeutics
Phase 1/2
203
California, Colorado, Connecticut, Maryland, Massachusetts, Missouri, North Carolina, Oklahoma
2023-09-05
Recruiting
SPEARHEAD-3 Pediatric Study
NCT05642455Synovial Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST), Neuroblastoma (NBL), Osteosarcoma
USWM CT, LLC
Phase 1/2
20
California, Maryland, Massachusetts, Missouri, New York, North Carolina, Ohio, Pennsylvania
2023-09-01
Active, closed
Enlighten Study: The EV-ICD Post Approval Registry
NCT06048731Ventricular Arrhythmia, Tachycardia
Medtronic
Observational
1,000
California, Connecticut, Florida, Georgia, Indiana, Iowa, Kentucky, Maryland
2023-09-01
Recruiting
Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth in/Near Infected Bone Cavities
NCT05361941Periprosthetic Joint Infections
Elute, Inc.
Not applicable
204
California, District of Columbia, Illinois, Indiana, Maryland, Massachusetts, Michigan, New York
2023-08-31
Active, closed
Pediatric Patients Aged 1 to 6 Years With APDS
NCT05693129APDS
DrugLeniolisib
Pharming Technologies B.V.
Phase 3
16
California, Maryland, Ohio, Texas
2023-08-30
Recruiting
A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma
NCT06023589Asthma
DrugTezepelumab
AstraZeneca
Phase 3
231
Alabama, Arizona, Arkansas, California, Georgia, Maryland, Massachusetts, Michigan
2023-08-24
Recruiting
A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis
NCT05995964Atopic Dermatitis
DrugTilrekimig
Pfizer
Phase 2
340
Alabama, Arizona, California, Colorado, Florida, Indiana, Maryland, Michigan
2023-08-22
Active, closed
Pharmacogenomics IND Commercial SNP Clinical Study - Abiraterone and Single Nucleotide Polymorphisms
NCT03348670Prostate Cancer
Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair
Phase 2/3
600
Maryland
2023-08-18
Recruiting
Regeneration of Acutely Injured Nerves With Temporary Electrical Stimulation
NCT05721261Nerve Injury
Epineuron Technologies Inc.
Not applicable
110
Florida, Louisiana, Maryland, Pennsylvania, Texas
2023-08-11
Active, closed
BCG in Combination With Durvalumab in Adult BCG-naïve, High-risk NMIBC Participants
NCT05943106Non-Muscle- Invasive Bladder Cancer
DrugDurvalumab
AstraZeneca
Phase 3
100
Arizona, Arkansas, California, Colorado, Florida, Indiana, Kansas, Maryland
2023-08-11
Active, closed
4D-150 in Patients With Diabetic Macular Edema
NCT05930561Diabetic Macular Edema, Diabetic Retinopathy
DrugsAflibercept IVT·4D-150 IVT·Eylea
4D Molecular Therapeutics
Phase 2
72
Maryland, Oregon, Pennsylvania, Texas, Virginia
2023-08-09
Recruiting
Confirmatory Clinical Evaluation of Novilase® Laser Therapy for Focal Destruction of Malignant Breast Tumors
NCT03463954Malignant Neoplasm of Breast
Novian Health Inc.
Not applicable
122
California, Connecticut, Maryland, New Jersey, New York
2023-08-09
Recruiting
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).
NCT05947851Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Chronic Lymphocytic, Small-Cell Lymphoma, Lymphoma, Small Lymphocytic
DrugsNemtabrutinib·Venetoclax·Rituximab
Merck Sharp & Dohme LLC
Phase 3
735
Arkansas, California, Florida, Indiana, Maryland, Mississippi, Missouri, Montana
2023-08-08
Recruiting
AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma
NCT05602363B-cell Malignancy, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Waldenstrom Macroglobulinemia
Carna Biosciences, Inc.
Phase 1
120
California, Florida, Illinois, Indiana, Maryland, Massachusetts, New York, North Carolina
2023-08-01
Active, closed
Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy
NCT05949593Geographic Atrophy
DrugTinlarebant
Belite Bio, Inc
Phase 3
429
Arizona, California, Florida, Maryland, Minnesota, New York, North Carolina, Oregon
2023-07-27
Active, closed
Cemented vs Cementless Persona Keel RCT
NCT05630053Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis
Zimmer Biomet
Not applicable
300
Colorado, Illinois, Maryland, Oregon, Pennsylvania, Virginia
2023-07-25
Recruiting
The Safety and Tolerability of LBS-007 in Patients With Relapsed or Resistant Acute Leukaemias
NCT05756322Relapsed or Resistant Acute Leukaemias
Lin BioScience, Inc
Phase 1/2
90
Florida, Illinois, Kansas, Maryland, North Carolina
2023-07-20
Active, closed
A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)
NCT05933577Melanoma
DrugsIntismeran autogene·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,089
Arkansas, California, Connecticut, Florida, Georgia, Iowa, Maryland, Massachusetts
2023-07-19
Recruiting
Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer
NCT05797831Endometrial Cancer
DrugNavtemadlin
Kartos Therapeutics, Inc.
Phase 2/3
268
California, Georgia, Illinois, Indiana, Maryland, Minnesota, Missouri, Nevada
2023-07-17
Active, closed
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy
NCT05819866Cerebral Adrenoleukodystrophy (cALD)
Minoryx Therapeutics, S.L.
Phase 3
40
California, Maryland, Massachusetts, Minnesota
2023-07-12
Recruiting
A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer
NCT05710848Non-muscle-invasive Bladder Cancer
SURGE Therapeutics
Phase 1/2
75
Arizona, Arkansas, California, Florida, Maryland, Massachusetts, Michigan, Ohio
2023-07-11
Active, closed
A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight
NCT05726227Obesity
DrugSemaglutide
Novo Nordisk A/S
Phase 3
210
California, Connecticut, Georgia, Idaho, Louisiana, Maryland, Massachusetts, Minnesota
2023-07-07
Recruiting
DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors
NCT05785754Advanced or Metastatic Solid Tumors
DrugsDCSZ11·Tebentafusp·Doxorubicin·Pembrolizumab
DynamiCure Biotechnology
Phase 1
320
Alabama, Arizona, Colorado, Connecticut, Florida, Maryland, Massachusetts, Minnesota
2023-06-28
Active, closed
Observational Basket Trial to Collect Tissue to Develop and Train a Live Tumor Diagnostic Platform (ELEPHAS-02)
NCT05520099Immunotherapy, Cancer, Bladder Cancer, Urothelial Carcinoma Bladder
Elephas
Observational
416
Arkansas, California, Florida, Kentucky, Maryland, New Jersey, New York, North Carolina
2023-06-26
Active, closed
A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma
NCT05827016Multiple Myeloma
DrugsIberdomide·Lenalidomide
Bristol-Myers Squibb
Phase 3
1,230
Colorado, Florida, Georgia, Illinois, Kansas, Maryland, Massachusetts, Michigan
2023-06-22
Active, closed
Advancing Cath Lab Results With FFRangio Coronary Physiology Assessment
NCT05893498Percutaneous Coronary Intervention
CathWorks Ltd.
Not applicable
1,924
California, Florida, Georgia, Illinois, Kansas, Kentucky, Maryland, Massachusetts
2023-06-21
Recruiting
A Retrospective Study to Characterize Participants With Propionic Acidemia
NCT05769621Propionic Acidemia
ModernaTX, Inc.
Observational
60
California, Maryland, Michigan, Pennsylvania, Texas, Washington
2023-06-16
Active, closed
A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
NCT05926765Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
MeiraGTx, LLC
Phase 2
290
Arizona, California, Florida, Iowa, Maryland, Massachusetts, Michigan, Missouri
2023-06-13
Active, closed
A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome
NCT05898620Rett Syndrome
Neurogene Inc.
Phase 3
33
Alabama, California, Colorado, Florida, Illinois, Maryland, Massachusetts, New York
2023-06-13
Active, closed
Study of LP-184 in Patients With Advanced Solid Tumors
NCT05933265Advanced Solid Tumor, Metastatic Solid Tumor, GBM, TNBC - Triple-Negative Breast Cancer
DrugsOlaparib·Ipilimumab
Lantern Pharma Inc.
Phase 1/2
64
Arkansas, Indiana, Kentucky, Maryland, Pennsylvania, Texas, Utah
2023-06-09
Recruiting
A Study of Eptinezumab in Pediatric Participants With Episodic Migraine
NCT05897320Episodic Migraine
DrugEptinezumab
H. Lundbeck A/S
Phase 3
315
Connecticut, Florida, Georgia, Kentucky, Maryland, Michigan, New York, North Carolina
2023-06-08
Active, closed
A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) in Non-Ambulatory and Ambulatory Participants With Duchenne Muscular Dystrophy (DMD)
NCT05881408Duchenne Muscular Dystrophy
Sarepta Therapeutics, Inc.
Phase 3
148
Arkansas, California, Florida, Illinois, Maryland, Massachusetts, Missouri, New York
2023-05-31
Active, closed
Study to Evaluate the Efficacy and Safety of BBP-418 (Ribitol) in Patients With Limb Girdle Muscular Dystrophy 2I (LGMD2I)
NCT05775848Limb-Girdle Muscular Dystrophy Type 2I (LGMD2I)
DrugRibitol
ML Bio Solutions, Inc.
Phase 3
112
Arkansas, California, Colorado, Florida, Iowa, Kansas, Maryland, Minnesota
2023-05-31
Active, closed
Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial
NCT05408546Pulmonary Embolism
DrugTS23
Translational Sciences, Inc.
Phase 2
64
Arizona, California, Georgia, Maryland, Massachusetts, Michigan, North Carolina, Ohio
2023-05-24
Recruiting
FOG-001 in Locally Advanced or Metastatic Solid Tumors
NCT05919264Cancer, Colorectal Cancer, Solid Tumor, Locally Advanced Solid Tumor
DrugsLonsurf·MFOLFOX6·Trifluridine/Tipiracil·Avastin
Parabilis Medicines, Inc.
Phase 1/2
619
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Maryland, Massachusetts
2023-05-23
Recruiting
Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma
NCT05734066Refractory Ewing Sarcoma, Relapsed Ewing Sarcoma, Ewing Sarcoma
DrugLurbinectedin
Jazz Pharmaceuticals
Phase 1/2
60
California, District of Columbia, Florida, Georgia, Maryland, Michigan, New York, Ohio
2023-05-23
Active, closed
iFuse TORQ for the Treatment of Sacroiliac Joint Dysfunction
NCT05870488Sacroiliac Joint Dysfunction, Sacroiliac; Fusion, Sacroiliac Disorder, Sacroiliac Joint Pain
SI-BONE, Inc.
Phase 4
110
California, Indiana, Kansas, Kentucky, Maryland, Missouri, Nevada, Oklahoma
2023-05-23
Active, closed
Water Vapor Ablation for Localized Intermediate Risk Prostate Cancer
NCT05683691Prostate Cancer
Francis Medical Inc.
Not applicable
400
Arizona, California, Florida, Illinois, Kansas, Maryland, Michigan, Minnesota
2023-05-16
Recruiting
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT05442567Ulcerative Colitis, Crohn's Disease
DrugVedolizumab
Takeda
Phase 3
240
Alabama, Arizona, California, Florida, Georgia, Illinois, Indiana, Maryland
2023-05-16
Active, closed
A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)
NCT05230459Limb Girdle Muscular Dystrophy, Limb-Girdle Muscular Dystrophy Type 2, LGMD2I, Muscular Dystrophy
AskBio Inc
Phase 1/2
9
California, Iowa, Kansas, Maryland, Virginia, Washington
2023-05-15
Recruiting
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
NCT05716100Focal Onset Seizures
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 3
360
Arkansas, California, Florida, Idaho, Illinois, Maryland, Michigan, New Jersey
2023-05-09
Active, closed
Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid Diseases
NCT05552469Myeloid Diseases
Novartis Pharmaceuticals
Phase 1
71
California, Florida, Illinois, Maryland, Massachusetts, Minnesota, New York, Tennessee
2023-05-08
Active, closed
Phase III Study of AK112 for NSCLC Patients
NCT06396065Non-Squamous Non-small Cell Lung Cancer
DrugsIvonescimab·Pemetrexed·Carboplatin
Summit Therapeutics
Phase 3
420
California, Colorado, Florida, Louisiana, Maine, Maryland, Massachusetts, Minnesota
2023-05-04
Recruiting
The Ailliance Post-Market Clinical Study
NCT05856370Spinal Deformity, Spinal Degenerative Disorder, Spinal Fusion Failure, Spinal Trauma
Medtronic Spinal and Biologics
Not applicable
1,000
Arizona, Arkansas, California, Indiana, Kentucky, Maryland, Michigan, Minnesota
2023-05-01
Recruiting
Comparison of Transforming Powder Dressing to NPIAP Recommended Standard of Care Therapies in Stage 2, 3 and 4 Pressure Injuries
NCT05496296Pressure Ulcers Stage II, Pressure Ulcers Stage III, Pressure Ulcer, Stage IV
ULURU Inc.
Not applicable
300
California, District of Columbia, Illinois, Maryland, New Jersey, New York, Pennsylvania, Texas
2023-04-30
Active, closed
A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advanced Unresectable or Metastatic Renal Cell Carcinoma
NCT05805501Renal Cell Carcinoma
DrugsTobemstomig·Tiragolumab·Axitinib·Keytruda
Hoffmann-La Roche
Phase 2
199
Alabama, California, Georgia, Maryland, Tennessee, Texas
2023-04-21
Active, closed
Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)
NCT05624749Systemic Lupus Erythematosus
DrugIanalumab
Novartis Pharmaceuticals
Phase 3
288
Alabama, California, Florida, Georgia, Illinois, Kentucky, Louisiana, Maryland
2023-04-21
Active, closed
Survival and Dialysis Independency in Highly Sensitized Patients After Desensitization With Imlifidase and Tx of Kidneys
NCT05714514Kidney Transplantation in Highly Sensitized Patients
DrugImlifidase
Hansa Biopharma AB
Observational
64
Alabama, California, Illinois, Maryland, Massachusetts, Missouri, New Jersey, New York
2023-04-21
Active, closed
Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab
NCT05626855Spinal Muscular Atrophy, Spinal Muscular Atrophy Type 3, Spinal Muscular Atrophy Type 2, SMA
DrugApitegromab
Scholar Rock, Inc.
Phase 3
238
Arizona, California, Colorado, Florida, Illinois, Iowa, Kansas, Maryland
2023-04-17
Recruiting
Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant
NCT05654922Pre-Bronchiolitis Obliterans Syndrome
Renovion, Inc.
Phase 3
100
Arizona, California, Florida, Illinois, Iowa, Maryland, Minnesota, Missouri
2023-04-10
Recruiting
A Study of GEn-1124 in Subjects With Acute Respiratory Distress Syndrome (ARDS)
NCT05795465Respiratory Distress Syndrome, Acute
GEn1E Lifesciences
Phase 2
52
District of Columbia, Kansas, Maryland, Mississippi, Missouri, New Jersey, New York, Ohio
2023-04-04
Active, closed
A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies
NCT05794906Biochemically Recurrent Prostate Cancer
DrugDarolutamide
Bayer
Phase 3
985
Arizona, California, Colorado, Illinois, Maryland, Massachusetts, Michigan, Minnesota
2023-04-03
Recruiting
Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
NCT05727904Metastatic Melanoma, Unresectable Melanoma, Melanoma
DrugsLifileucel·Pembrolizumab
Iovance Biotherapeutics, Inc.
Phase 3
670
Alabama, California, Colorado, Florida, Illinois, Kansas, Kentucky, Maryland
2023-03-30
Recruiting
A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma
NCT05440708Hepatocellular Carcinoma
DrugsTecentriq·Avastin·Atezolizumab·Keytruda
Tvardi Therapeutics, Incorporated
Phase 1/2
193
Alabama, California, Colorado, District of Columbia, Florida, Maryland, Michigan, Missouri
2023-03-23
Recruiting
A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251
NCT05626114Geographic Atrophy
DrugOpRegen
Genentech, Inc.
Phase 2
60
California, Florida, Maryland, Missouri, Nevada, North Carolina, Ohio, Pennsylvania
2023-03-23
Recruiting
A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma
NCT05650632Multiple Myeloma
DrugEtentamig
AbbVie
Phase 1
210
Arizona, Arkansas, Colorado, Delaware, Illinois, Indiana, Louisiana, Maryland
2023-03-21
Active, closed
Thoraflex Hybrid and Relay Extension Post-Approval Study
NCT05639400Thoracic Diseases, Aortic Aneurysm, Aortic Dissection, Thoracic Aortic Aneurysm
Vascutek Ltd.
Observational
352
Alabama, California, Colorado, Connecticut, District of Columbia, Illinois, Indiana, Maryland
2023-03-17
Active, closed
An Open-label Study of Povetacicept in Autoantibody-Associated Glomerular Diseases
NCT05732402Lupus Nephritis, Immunoglobulin A Nephropathy, Membranous Nephropathy, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
DrugPovetacicept
Alpine Immune Sciences, Inc.
Phase 1/2
72
Arizona, California, Colorado, Florida, Georgia, Maryland, Massachusetts, Missouri
2023-03-15
Active, closed
Safety and Effectiveness of the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal or Persistent Atrial Fibrillation
NCT05462145Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Kardium Inc.
Not applicable
549
Alabama, Arkansas, California, Florida, Maryland, Michigan, New York, Ohio
2023-03-09
Active, closed
Honeycomb: Evaluation of Radiprodil in Children with GRIN-related Disorder
NCT05818943GRIN-related Disorders
DrugRadiprodil
GRIN Therapeutics, Inc.
Phase 1
24
Maryland, New York
2023-03-07
Active, closed
A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma
NCT05625399Melanoma
DrugsPhesgo·Relatlimab·Nivolumab
Bristol-Myers Squibb
Phase 3
579
Arizona, Arkansas, California, Colorado, Florida, Maryland, Minnesota, Nebraska
2023-03-06
Active, closed
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study)
NCT05606614Rett Syndrome
Taysha Gene Therapies, Inc.
Phase 3
17
California, Illinois, Maryland, Massachusetts, Missouri, Texas
2023-03-06
Recruiting
Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas
NCT05768919Glioblastoma
SignPath Pharma, Inc.
Phase 1/2
30
District of Columbia, Maryland
2023-03-03
Active, closed
Efficacy and Safety of ATX01 in Adult Patients With CIPN (Chemotherapy-induced Peripheral Neuropathy)
NCT05593614Chemotherapy-induced Peripheral Neuropathy
AlgoTherapeutix
Phase 2
276
Florida, Kansas, Maryland, New York, Texas
2023-02-28
Active, closed
A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)
NCT05668741Cystic Fibrosis
DrugIvacaftor
Vertex Pharmaceuticals Incorporated
Phase 1/2
26
Alabama, California, Colorado, Kansas, Maryland, Massachusetts, Minnesota, Missouri
2023-02-27
Active, closed
Safety and Efficacy of the Bacteriophage Preparation, ShigActive™, in a Human Experimental Model of Shigellosis
NCT05182749Shigellosis
DrugBacteriophage
Intralytix, Inc.
Phase 1/2
52
Maryland
2023-02-23
Recruiting
A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
NCT05503797Cancer Harboring BRAF Alterations, HGG, LGG, Solid Tumors
Fore Biotherapeutics
Phase 2
254
California, Connecticut, Florida, Maryland, Massachusetts, Minnesota, Missouri, Nebraska
2023-02-21
Recruiting
VIrtual STudy in Achondroplasia for the US (VISTA)
NCT06168201Achondroplasia
BioMarin Pharmaceutical
Observational
170
California, Maryland, North Carolina, Ohio, South Dakota, Texas, Wisconsin
2023-02-21
Recruiting
Phase II IMNN-001 (Also Known as GEN-1) on SLL With BEV and NACT, Newly Diagnosed Advanced Ovarian, Fallopian Tube or Primary Peritoneal Cancer
NCT05739981Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
DrugsIMNN-001·Paclitaxel·Bevacizumab·Carboplatin
Imunon
Phase 1/2
30
Maryland, New York, Oklahoma, Texas
2023-02-10
Active, closed
A Safety and Efficacy Study of PVX108 in Children and Adolescents With Peanut Allergy
NCT05621317Peanut Allergy, Peanut Hypersensitivity, Peanut-Induced Anaphylaxis, Immune System Diseases
Aravax Pty Ltd
Phase 2
90
Arkansas, California, Georgia, Indiana, Maryland, Massachusetts, North Carolina
2023-02-09
Recruiting
A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition
NCT05519475Metabolic Dysfunction-Associated SteatoHepatitis (MASH)
Regeneron Pharmaceuticals
Phase 2
120
Arizona, California, Colorado, Florida, Indiana, Louisiana, Maryland, Mississippi
2023-02-09
Active, closed
A Study to Evaluate RO7204239 in Participants With Facioscapulohumeral Muscular Dystrophy
NCT05548556Facioscapulohumeral Muscular Dystrophy (FSHD)
DrugRO7204239
Hoffmann-La Roche
Phase 2
51
California, Colorado, Kansas, Maryland
2023-02-07
Active, closed
Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study
NCT05797896Dry Age-related Macular Degeneration, Geographic Atrophy, Retinal Disease, Macular Degeneration
Complement Therapeutics
Observational
250
California, Indiana, Maryland, Nevada, Oregon, Pennsylvania, Texas
2023-02-07
By invitation
A Study to Follow Patients With Adult Growth Hormone Deficiency (AGHD) Treated With Sogroya® for Long Term Safety Information
NCT05718570Adult Growth Hormone Deficiency
DrugSomapacitan
Novo Nordisk A/S
Observational
400
Arizona, California, Colorado, Florida, Georgia, Illinois, Maryland, Massachusetts
2023-02-03
Active, closed
Study of Ianalumab Versus Placebo in Addition to First-line Corticosteroids in Primary Immune Thrombocytopenia (ITP)
NCT05653349Primary Immune Thrombocytopenia (ITP)
DrugIanalumab
Novartis Pharmaceuticals
Phase 3
226
Arizona, California, Colorado, Florida, Illinois, Indiana, Maryland, Massachusetts
2023-02-03
Active, closed
Pilot/Pivotal Study of DBS+Rehab After Stroke
NCT05701280Stroke, Upper Extremity Paresis
Enspire DBS Therapy, Inc.
Not applicable
202
Arizona, Maryland, Massachusetts, Minnesota, New York, Ohio, Pennsylvania, Rhode Island
2023-02-03
Active, closed
Pediatric Patients Aged 4 to 11 Years With APDS
NCT05438407APDS
DrugLeniolisib
Pharming Technologies B.V.
Phase 3
15
California, Georgia, Maryland
2023-02-01
Active, closed
A Study of Gilteritinib, Venetoclax and Azacitidine as a Combined Treatment for People Newly Diagnosed With Acute Myeloid Leukemia
NCT05520567Acute Myeloid Leukemia (AML), FLT3-mutated Acute Myeloid Leukemia
DrugsXospata·Gilteritinib·Venclexta·Azacitidine
Astellas Pharma Global Development, Inc.
Phase 1/2
70
California, Colorado, Florida, Illinois, Maryland, New York, North Carolina, Ohio
2023-01-31
Recruiting
Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
NCT06311708Arrhythmogenic Right Ventricular Cardiomyopathy
Tenaya Therapeutics
Observational
200
California, Colorado, Maryland, Massachusetts, Minnesota, New York, Ohio, South Carolina
2023-01-31
Active, closed
Observational Lung Trial to Collect Tissue to Train and Validate a Live Tumor Diagnostic Platform (ELEPHAS-01)
NCT05478538NSCLC (Non-small Cell Lung Cancer), Metastatic NSCLC - Non-Small Cell Lung Cancer
Elephas
Observational
200
California, Maryland, New York, North Carolina, Ohio, Texas
2023-01-31
Active, closed
Open-Label Extension Study of DCCR in Patients With Prader-Willi Syndrome
NCT05701774Prader-Willi Syndrome
Soleno Therapeutics, Inc.
Phase 3
83
California, Florida, Georgia, Indiana, Maryland, Massachusetts, Michigan, Minnesota
2023-01-31
Recruiting
MYLUNG Consortium Part 3: Observational Study
NCT05885698Carcinoma, Non-Small-Cell Lung
US Oncology Research
Observational
7,500
Alabama, Arizona, Colorado, Florida, Illinois, Maryland, Minnesota, New York
2023-01-30
Active, closed
A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder
NCT05733546Major Depressive Disorder
DrugPsilocybin
COMPASS Pathways
Phase 2
102
California, Florida, Maryland, Massachusetts, Texas
2023-01-30
Recruiting
A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
NCT04782258Autosomal Recessive Polycystic Kidney (ARPKD)
DrugTolvaptan
Otsuka Pharmaceutical Development & Commercialization, Inc.
Phase 3
20
District of Columbia, Georgia, Illinois, Indiana, Louisiana, Maryland, Michigan, Minnesota
2023-01-23
Recruiting
A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications
NCT05539196Movement Disorders, Neurology, Parkinsons Disease
InSightec
Observational
60
Maryland, New York, Pennsylvania, Texas
2023-01-23
Active, closed
SKB264 in Combination With Pembrolizumab in Subjects With Selected Solid Tumors
NCT05642780Solid Tumor
DrugsSacituzumab tirumotecan·Keytruda·Pembrolizumab
Klus Pharma Inc.
Phase 2
240
Indiana, Kentucky, Maryland, Minnesota, New York, Texas, Virginia
2023-01-17
Recruiting
FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3
NCT05614739Urinary Bladder Neoplasms, Neoplasm Metastasis, Ureteral Neoplasms
DrugsVepugratinib·Digoxin·Enfortumab Vedotin·Rosuvastatin
Eli Lilly and Company
Phase 1
677
Arizona, California, Florida, Georgia, Illinois, Indiana, Louisiana, Maryland
2023-01-12
Active, closed
Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)
NCT05555732Metastatic Non Small Cell Lung Cancer
DrugsDato-DXd·Pemetrexed·Keytruda·Cisplatin
Daiichi Sankyo
Phase 3
1,170
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Maryland
2023-01-11
Active, closed
A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)
NCT05552976Relapsed or Refractory Multiple Myeloma
DrugsMezigdomide·Carfilzomib·Dexamethasone
Bristol-Myers Squibb
Phase 3
606
Alabama, California, Florida, Georgia, Idaho, Maryland, Massachusetts, Minnesota
2023-01-10
Active, closed
A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002)
NCT05506943Biliary Tract Cancer, Cholangiocarcinoma, Gall Bladder Cancer, Ampullary Cancer
DrugPaclitaxel
Compass Therapeutics
Phase 2/3
168
Arizona, California, Colorado, Florida, Illinois, Louisiana, Maryland, Massachusetts
2023-01-09
Active, closed
Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1
NCT05680818Autosomal Dominant Hypocalcemia (ADH)
DrugEncaleret
Calcilytix Therapeutics, Inc., a BridgeBio company
Phase 3
67
California, Colorado, Indiana, Maryland, Massachusetts, Minnesota, New York, North Carolina
2023-01-06
Recruiting
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
NCT05592626Advanced Solid Tumors, Genital Neoplasm, Female, Urogenital Neoplasms, Lung Neoplasm
DrugSTAR0602
Marengo Therapeutics, Inc.
Phase 1/2
366
California, Florida, Kansas, Maryland, Massachusetts, Michigan, Ohio, Tennessee
2023-01-04
Active, closed
Study of AC699 in Patients With Estrogen Receptor Positive/Human Epidermal Growth Factor Receptor 2 Negative (ER+/HER2-) Locally Advanced or Metastatic Breast Cancer
NCT05654532Breast Cancer
Accutar Biotechnology Inc
Phase 1
100
Colorado, Florida, Maryland, Tennessee, Texas, Virginia, Washington
2022-12-29
Active, closed
Study of ONCOFID-P-B (PACLITAXEL-HYALURONIC ACID)
NCT05024773Bladder Carcinoma in Situ (CIS)
Fidia Farmaceutici s.p.a.
Phase 3
130
Arizona, Louisiana, Maryland, Minnesota, Ohio, South Carolina
2022-12-29
Active, closed
A Study to Assess Safety and Effectiveness of Elafibranor in Adult Participants With Primary Sclerosing Cholangitis.
NCT05627362Primary Sclerosing Cholangitis
DrugElafibranor
Ipsen
Phase 2
68
California, Colorado, Connecticut, Florida, Georgia, Louisiana, Maryland, Massachusetts
2022-12-29
By invitation
Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema
NCT05396105Hereditary Angioedema, Hereditary Angioedema Type I, Hereditary Angioedema Type II, Hereditary Angioedema Types I and II
DrugDeucrictibant
Pharvaris Netherlands B.V.
Phase 2/3
150
Alabama, Arkansas, California, Colorado, Maryland, Massachusetts, Michigan, Missouri
2022-12-28
By invitation
Safety Extension Study for Subjects With HR+, HER2- Breast Cancer for Subjects Who Have Completed the OVELIA Study
NCT05645536Breast Cancer
DrugsTOL2506·Tamoxifen·Exemestane·Anastrozole
Tolmar Inc.
Phase 3
250
California, Florida, Kentucky, Maryland, New York, North Carolina, Pennsylvania, Tennessee
2022-12-28
Recruiting
A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma
NCT05645107Hypogammaglobulinemia, Bacterial Infections, B-cell Chronic Lymphocytic Leukemia, Multiple Myleoma
DrugXembify
Grifols Therapeutics LLC
Phase 3
386
Arizona, California, Florida, Maryland, North Carolina, Ohio, South Carolina
2022-12-26
Recruiting
Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
NCT05283330Cervical Cancer, Breast Cancer, Colon Cancer, NSCLC
Orano Med Theranostics, SAS
Phase 1
48
Illinois, Iowa, Kentucky, Maryland, Nebraska, Pennsylvania
2022-12-22
Active, closed
First in Human Study of AZD9592 in Solid Tumors
NCT05647122Advanced Solid Tumours, Carcinoma Non-small Cell Lung, Head and Neck Neoplasms, Colorectal Neoplasms
DrugsAZD9592·Osimertinib·Leucovorin·Adrucil
AstraZeneca
Phase 1
190
California, Connecticut, District of Columbia, Illinois, Maryland, Massachusetts, New York, Pennsylvania
2022-12-21
Active, closed
Study of CHS-114 in Participants With Advanced Solid Tumors
NCT05635643Advanced Solid Tumor, Head and Neck Squamous Cell Carcinoma
DrugsCHS-114·Toripalimab
Coherus Oncology, Inc.
Phase 1
87
California, Georgia, Kentucky, Maryland, Michigan, Missouri, Ohio, Tennessee
2022-12-15
Active, closed
A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma
NCT05675449Multiple Myeloma
DrugsElranatamab·Carfilzomib
Pfizer
Phase 1
59
Arkansas, California, Florida, Georgia, Iowa, Maryland, Massachusetts, New Jersey
2022-12-14
Recruiting
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease
NCT05650229Primary Mitochondrial Disease
DrugNapazimone
Pharming Technologies B.V.
Phase 2
180
California, Colorado, Connecticut, Florida, Georgia, Indiana, Maryland, Minnesota
2022-12-13
Active, closed
A Research Study to Evaluate the Effects of a New Oral Medicine Called Cenerimod in Adults With Systemic Lupus Erythematosus
NCT05648500Lupus Erythematosus, Systemic
DrugCenerimod
Viatris Innovation GmbH
Phase 3
470
California, Colorado, Florida, Georgia, Illinois, Louisiana, Maryland, New York
2022-12-13
Active, closed
(HALT) Embrace Hydrogel Embolic System (HES) Study of Embolization in Peripheral Arterial Bleeds
NCT05364502Arterial Bleeding in Solid Organs and Peripheral Arteries
Instylla, Inc.
Not applicable
130
Arizona, California, Connecticut, District of Columbia, Florida, Illinois, Indiana, Maryland
2022-12-12
Active, closed
Dose Finding Study to Evaluate Safety and Efficacy of 3 Dosages of SAP 001.
NCT05690204Gout
DrugColchicine
Shanton Pharma Pte. Ltd.
Phase 2
87
California, Colorado, Florida, Idaho, Maryland, Mississippi, North Carolina, Texas
2022-12-12
Active, closed
A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7497372 in Participants With Diabetic Macular Edema (DME)
NCT06847854Diabetic Macular Edema
Genentech, Inc.
Phase 1
151
Arizona, Arkansas, California, Florida, Maryland, Michigan, Minnesota, Mississippi
2022-12-08
Recruiting
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
NCT05579366High Grade Epithelial Ovarian Cancer, High Grade Serous Ovarian Cancer, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
DrugsRina-S·Bevacizumab·Carboplatin·Pembrolizumab
Genmab
Phase 1/2
884
Arizona, California, Florida, Georgia, Kansas, Maryland, Massachusetts, Michigan
2022-12-07
Active, closed
Study of Cell Therapies for the Treatment of Patients With Relapsed or Refractory Acute Myeloid Leukemia or High-risk Myelodysplastic Syndrome.
NCT05457010Acute Myeloid Leukemia, Myelodysplastic Syndromes
DrugsSPRX002·Fludarabine·Cyclophosphamide
Kite, A Gilead Company
Phase 1
24
California, Maryland, Massachusetts, New York, Texas
2022-11-28
Active, closed
A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
NCT05476926Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Branch Retinal Vein Occlusion
DrugsVabysmo·Faricimab
Hoffmann-La Roche
Observational
6,000
Arizona, California, Florida, Illinois, Kentucky, Maryland, Michigan, Pennsylvania
2022-11-21
Recruiting
A Study to Evaluate Glofitamab Monotherapy and Glofitamab + Chemoimmunotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Mature B-Cell Non-Hodgkin Lymphoma
NCT05533775Mature B-Cell Non-Hodgkin Lymphoma
DrugsIfosfamide·Glofitamab·Tocilizumab·Obinutuzumab
Hoffmann-La Roche
Phase 1/2
65
Alabama, California, Maryland, Massachusetts, Missouri, New York, Ohio
2022-11-16
Active, closed
Study of Iadademstat and Gilteritinib in Patients With R/R AML With FMS-like Tyrosine Kinase Mutation (FLT3 Mut+)
NCT05546580Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory
DrugsXospata·Gilteritinib
Oryzon Genomics S.A.
Phase 1
50
Arizona, Florida, Maryland, Massachusetts, New Jersey, New York, North Carolina, Oregon
2022-11-14
Recruiting
A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
NCT05498428Carcinoma, Non-small-Cell Lung
DrugsDirect Anticoagulant·LMWH·DOAC·Low molecular weight heparin
Janssen Research & Development, LLC
Phase 2
520
California, District of Columbia, Florida, Kansas, Maryland, Massachusetts, Missouri, New Jersey
2022-11-11
Recruiting
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
NCT05457283Chronic Kidney Disease, Proteinuria, Children
DrugFinerenone
Bayer
Phase 3
100
Arizona, California, District of Columbia, Florida, Georgia, Iowa, Maryland, Massachusetts
2022-11-08
Active, closed
LAMBDA 002 (Lung Registry) Study
NCT05170425Lung Transplant Rejection
Natera, Inc.
Observational
154
California, Illinois, Maryland, Michigan, Missouri, New York, Ohio, Texas
2022-11-04
Active, closed
A Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation (ALLOHA)
NCT05473910AML, MDS
DrugTSC-101
TScan Therapeutics, Inc.
Phase 1
310
California, Colorado, Connecticut, Florida, Georgia, Maryland, Massachusetts, Michigan
2022-11-01
Active, closed
An Open-Label Extension Study of BPN14770 in Subjects With Fragile X Syndrome
NCT05367960Fragile X Syndrome
Tetra Discovery Partners
Phase 3
314
California, Colorado, Florida, Georgia, Illinois, Kansas, Maryland, Massachusetts
2022-11-01
Active, closed
A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH
NCT05389449Paroxysmal Nocturnal Hemoglobinuria
DrugDanicopan
Alexion Pharmaceuticals, Inc.
Phase 3
80
California, Illinois, Maryland, Missouri, New York, Ohio, Texas
2022-10-28
Recruiting
A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting
NCT05452941Pneumonia
Pfizer
Observational
12,500
California, Connecticut, District of Columbia, Georgia, Kentucky, Louisiana, Maryland, Massachusetts
2022-10-27
Recruiting
A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors
NCT05536141Clear Cell Renal Cell Carcinoma, Solid Tumors
DrugsCasdatifan·Zimberelimab·Cabozantinib·Ipilimumab
Arcus Biosciences, Inc.
Phase 1
362
Alabama, California, Florida, Georgia, Kentucky, Louisiana, Maryland, Massachusetts
2022-10-26
Active, closed
A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV
NCT05481151Polycythemia Vera
DrugBesremi
PharmaEssentia
Phase 3
111
Florida, Indiana, Kansas, Kentucky, Louisiana, Maryland, Missouri, New Jersey
2022-10-26
Active, closed
A Study of EDG-5506 in Children With Duchenne Muscular Dystrophy (LYNX)
NCT05540860Duchenne Muscular Dystrophy
DrugsSevasemten 1·Sevasemten 2·Sevasemten 3
Edgewise Therapeutics, Inc.
Phase 2
76
Arkansas, California, Colorado, Florida, Georgia, Iowa, Kansas, Maryland
2022-10-24
Active, closed
A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma
NCT05259839Relapsed/Refractory Multiple Myeloma
DrugsEtentamig·Pomalidomide·Daratumumab·Lenalidomide
AbbVie
Phase 1
283
Arkansas, Florida, Maryland, Massachusetts, Michigan, New Jersey, New York, North Carolina
2022-10-20
Recruiting
A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma
NCT05372354Multiple Myeloma
DrugsBMS-986158·Tazemetostat·Mezigdomide·Trametinib
Bristol-Myers Squibb
Phase 1/2
260
Alabama, Maryland, Massachusetts, New Jersey, New York
2022-10-18
Active, closed
A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma
NCT05535244Multiple Myeloma
DrugsCevostamab·Tocilizumab
Hoffmann-La Roche
Phase 1/2
90
Colorado, Florida, Maryland, Massachusetts, Minnesota, New York, Tennessee, Utah
2022-10-17
Active, closed
Clinical Trial on Agitation in Alzheimer's Dementia
NCT05543681Alzheimer Disease, Agitation,Psychomotor, Care Giving Burden, NPS
IGC Pharma, LLC
Phase 2
164
Florida, Louisiana, Maryland, Missouri, New York, Oklahoma, Rhode Island, Texas
2022-10-11
Recruiting
Rocket Study: A Study to Characterize Biomarkers and Disease Progression in Participants With Pelizaeus-Merzbacher Disease
NCT05659901Pelizaeus-Merzbacher Disease
Ionis Pharmaceuticals, Inc.
Observational
32
Georgia, Maryland, Pennsylvania
2022-10-03
Active, closed
Evaluating Safety and Efficacy of ADX-914 in Patients With Moderate to Severe Atopic Dermatitis (SIGNAL-AD)
NCT05509023Atopic Dermatitis
DrugBempikibart
Q32 Bio Inc.
Phase 2
102
Alabama, California, Florida, Georgia, Idaho, Illinois, Indiana, Maryland
2022-09-30
Recruiting
Study to Evaluate the Safety and Efficacy of Oral NRC-2694-A in Combination With Paclitaxel in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma, Who Progressed on or After Immune Checkpoint Inhibitor Therapy
NCT05283226Carcinoma, Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma
DrugPaclitaxel
NATCO Pharma Ltd.
Phase 2
21
California, Florida, Kentucky, Maryland, Missouri, New Hampshire, Pennsylvania, Wisconsin
2022-09-30
Active, closed
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis
NCT05503264NMDAR Autoimmune Encephalitis, LGI1 Autoimmune Encephalitis
DrugSatralizumab
Hoffmann-La Roche
Phase 3
122
Alabama, California, Colorado, District of Columbia, Georgia, Maryland, Massachusetts, Minnesota
2022-09-27
Recruiting
Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
NCT05327114Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
DrugNipocalimab
Janssen Research & Development, LLC
Phase 2/3
201
Colorado, Florida, Georgia, Kansas, Maryland, Massachusetts, Michigan, Missouri
2022-09-23
Active, closed
Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma
NCT05371093Relapsed/Refractory Follicular Lymphoma
DrugsAxi-cel·Axicabtagene Ciloleucel·Bendamustine·Vincristine
Kite, A Gilead Company
Phase 3
231
California, Florida, Kansas, Maryland, Massachusetts, North Carolina, Pennsylvania, Tennessee
2022-09-22
Recruiting
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
NCT05519085Relapsed or Refractory Multiple Myeloma
DrugsMezigdomide·Velcade·Pomalidomide·Bortezomib
Celgene
Phase 3
810
California, Colorado, Connecticut, Florida, Georgia, Kansas, Louisiana, Maryland
2022-09-20
Active, closed
MicroVention, Inc. Flow Re-Direction Endoluminal Device X (FRED™ X™) Post-Approval Study
NCT05409989Intracranial Aneurysm
Microvention-Terumo, Inc.
Not applicable
154
Florida, Hawaii, Iowa, Kansas, Kentucky, Louisiana, Maryland, Massachusetts
2022-09-20
Recruiting
A Prospective Study to Evaluate the WP in Comparison to PSG in Patients Suspected of Sleep Disorders
NCT06093633Sleep Disorder
Itamar-Medical, Israel
Observational
600
Maryland
2022-09-19
Active, closed
Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors
NCT05462717Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma, Advanced Solid Tumor
DrugElironrasib
Revolution Medicines, Inc.
Phase 1
222
Arkansas, California, Florida, Maryland, Massachusetts, New York, Tennessee, Texas
2022-09-19
Active, closed
A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy
NCT05450692Advanced or Metastatic Non-Small Cell Lung Cancer
DrugsCeralasertib·Durvalumab·Docetaxel
AstraZeneca
Phase 3
594
Alabama, Arizona, California, Florida, Georgia, Indiana, Maryland, Mississippi
2022-09-15
Recruiting
Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)
NCT05519449Prostate Cancer, Metastatic Castration-resistant Prostate Cancer, Castration Resistant Prostatic Cancer
DrugsJANX007·Darolutamide
Janux Therapeutics
Phase 1
272
Alabama, Arizona, California, Connecticut, Florida, Illinois, Maryland, Minnesota
2022-09-15
Active, closed
Study of Sonrotoclax (BGB-11417) Monotherapy in Participants With Relapsed or Refractory Mantle Cell Lymphoma
NCT05471843Mantle Cell Lymphoma, Refractory Mantle Cell Lymphoma (MCL), Relapsed Mantle Cell Lymphoma
DrugSonrotoclax
BeOne Medicines
Phase 1/2
125
Alabama, Indiana, Louisiana, Maryland, New Jersey, Texas
2022-09-05
Recruiting
Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT05168566Non-small Cell Lung Cancer
DrugSutetinib Maleate
Teligene US
Phase 2
99
California, Georgia, Kentucky, Maryland, North Carolina, Texas
2022-09-01
Recruiting
Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)
NCT05281471Platinum-resistant Ovarian Cancer, Platinum-refractory Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
DrugsOlvimulogene nanivacirepvec·Pegylated liposomal doxorubicin·Nab-paclitaxel·Bevacizumab
Genelux Corporation
Phase 3
186
Alabama, Arizona, California, Florida, Georgia, Indiana, Maryland, Michigan
2022-08-31
Active, closed
Safety, Tolerability and PK of Subcutaneous D-4517.2 in Subjects With Wet AMD or DME
NCT05387837Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
DrugAflibercept
Ashvattha Therapeutics, Inc.
Phase 2
50
California, Illinois, Indiana, Maryland, Massachusetts, Missouri, New Jersey, Pennsylvania
2022-08-31
Active, closed
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease
NCT05271409Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)
DrugSatralizumab
Hoffmann-La Roche
Phase 3
132
Alabama, California, Colorado, District of Columbia, Florida, Maryland, Massachusetts, Michigan
2022-08-30
Recruiting
Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears
NCT05444465Rotator Cuff Injuries
Smith & Nephew, Inc.
Not applicable
234
Georgia, Illinois, Maryland, Ohio, Pennsylvania, Texas, Wisconsin
2022-08-30
Active, closed
Post Approval Study - Evaluate the Long-Term Safety and Effectiveness of the WEB Device
NCT04839705Wide Neck Bifurcation Intracranial Aneurysms
Microvention-Terumo, Inc.
Not applicable
195
Florida, Hawaii, Iowa, Kansas, Kentucky, Louisiana, Maryland, Massachusetts
2022-08-24
Recruiting
BP1001-A in Patients With Advanced or Recurrent Solid Tumors
NCT04196257Solid Tumor, Adult, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Endometrial Cancer
Bio-Path Holdings, Inc.
Phase 1
50
Maryland, Michigan, Texas
2022-08-19
Active, closed
A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)
NCT05327530Locally Advanced or Metastatic Urothelial Carcinoma
DrugsAvelumab·Sacituzumab Govitecan
EMD Serono Research & Development Institute, Inc.
Phase 2
256
Idaho, Kansas, Maryland, Missouri, Washington, Wisconsin
2022-08-17
Active, closed
Study of the CycloPen Micro-Interventional System and Long-Term Clinical Outcomes
NCT05506423Open Angle Glaucoma
Iantrek, Inc.
Observational
300
California, Florida, Georgia, Maryland, Nevada, New Jersey, New York, Pennsylvania
2022-08-17
Recruiting
Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
NCT05317858Brain Tumor, Non Small Cell Lung Cancer
DrugsCemiplimab·Tecentriq·Atezolizumab·Nivolumab
InSightec
Phase 3
30
Arizona, California, Florida, Maryland, North Carolina, Oregon, Rhode Island, Virginia
2022-08-12
Active, closed
A Study of Ceralasertib Monotherapy and Ceralasertib Plus Durvalumab in Patients With Melanoma and Resistance to PD-(L)1 Inhibition
NCT05061134Melanoma
DrugsCeralasertib·Durvalumab
AstraZeneca
Phase 2
194
California, Florida, Maryland, Tennessee
2022-08-11
Recruiting
Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
NCT05268289Lupus Nephritis
DrugIptacopan
Novartis Pharmaceuticals
Phase 2
240
Arizona, California, Colorado, Florida, Illinois, Kansas, Louisiana, Maryland
2022-08-10
Active, closed
A Study on the Long-term Efficacy, Safety and Persistence of Immune Response of a Vaccine Against Herpes Zoster in Older Adults
NCT05371080Herpes Zoster
GlaxoSmithKline
Phase 3
3,038
Arizona, Maryland, North Carolina, Pennsylvania, Tennessee, Texas, Utah
2022-08-10
Active, closed
Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Subacute and Chronic Iliofemoral DVT
NCT04858776Iliofemoral; Thrombosis
Mercator MedSystems, Inc.
Phase 2
60
Connecticut, Florida, Illinois, Louisiana, Maryland, New York, North Carolina, Ohio
2022-08-08
Active, closed
A Study to Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)
NCT05092347Chronic Kidney Disease (CKD)
DrugVonsetamig
Regeneron Pharmaceuticals
Phase 1/2
43
California, Connecticut, District of Columbia, Illinois, Maryland, Minnesota, New York, Pennsylvania
2022-08-02
Recruiting
CorMatrix Cor TRICUSPID ECM Valve Replacement Study
NCT02397668Tricuspid Valve Disease
Corvivo Cardiovascular, Inc.
Not applicable
78
Alabama, Indiana, Maryland, Ohio
2022-08-01
Recruiting
A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM
NCT05303467Glioblastoma Multiforme, Recurrent Glioblastoma
Boston Scientific Corporation
Phase 1
36
Alabama, California, Florida, Illinois, Maryland, Missouri, New York, Texas
2022-07-30
Recruiting
A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer
NCT05379595Advanced or Metastatic Colorectal Cancer
DrugsAmivantamab·Fluorouracil·Leucovorin·Irinotecan
Janssen Research & Development, LLC
Phase 1/2
225
Alabama, California, District of Columbia, Florida, Maryland, Michigan, Mississippi, New York
2022-07-29
Recruiting
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT05254743Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma
DrugsPirtobrutinib·Ibrutinib
Loxo Oncology, Inc.
Phase 3
737
California, Florida, Louisiana, Maryland, Montana, Pennsylvania, South Carolina, Tennessee
2022-07-22
Active, closed
A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
NCT05458297Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma
DrugsZilovertamab vedotin·Nemtabrutinib
Merck Sharp & Dohme LLC
Phase 2
189
Alaska, Arizona, Colorado, Illinois, Kansas, Kentucky, Maryland, Massachusetts
2022-07-21
Recruiting
Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier
NCT06426628Pulmonary Nodule, Solitary, Lung Cancer
Veracyte, Inc.
Observational
2,400
Connecticut, Florida, Illinois, Kansas, Kentucky, Louisiana, Maryland, Massachusetts
2022-07-18
Active, closed
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
NCT05296798Locally Advanced or Metastatic Breast Cancer
DrugsGiredestrant·Phesgo·Pertuzumab·Trastuzumab
Hoffmann-La Roche
Phase 3
922
Arizona, California, Florida, Maryland, Tennessee, Texas, Washington
2022-07-18
Active, closed
Study of Anitocabtagene-autoleucel in Relapsed or Refractory Multiple Myeloma (iMMagine-1)
NCT05396885Multiple Myeloma
DrugAnitocabtagene Autoleucel
Kite, A Gilead Company
Phase 2
136
Arizona, Arkansas, Colorado, Florida, Georgia, Illinois, Maryland, Massachusetts
2022-07-15
Recruiting
A Study on the Safety of Ozanimod Exposure in Pregnant Women and Their Offspring
NCT05170126Multiple Sclerosis
Bristol-Myers Squibb
Observational
1,182
Maryland
2022-07-15
Recruiting
Safety and Effectiveness of the HIT Reverse HRS
NCT05357378Degenerative Joint Disease, Osteoarthritis, Hip, Avascular Necrosis of Hip, Traumatic Arthropathy-Hip
Hip Innovation Technology
Not applicable
288
Florida, Maryland, New Jersey, Ohio
2022-07-15
Recruiting
Tempus Small Cell Lung Cancer Observational Study (Sculptor)
NCT05257551Small Cell Lung Cancer
Tempus AI
Observational
200
California, Colorado, Illinois, Maryland, New Jersey, North Carolina, Ohio, Oklahoma
2022-07-13
Active, closed
A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies
NCT05362773Leukemia, Acute Myeloid, Myelodysplastic Syndromes, Classical Hodgkin Lymphoma, Leukemia, B-cell
MacroGenics
Phase 1
130
Colorado, Maryland, Massachusetts, Michigan, Missouri, North Carolina, Texas
2022-07-13
By invitation
ORACLE: A Long-term Follow-up Study to Evaluate the Safety of GT005 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration Treated in a Gyroscope-sponsored Antecedent Study
NCT05481827Age Related Macular Degeneration (AMD)
Gyroscope Therapeutics Limited
Phase 2
225
California, Colorado, Florida, Illinois, Indiana, Iowa, Maryland, Massachusetts
2022-07-12
Recruiting
Deep Neural Network Stratification for Use Detecting Endometriosis in Women Affected by Chronic Pelvic Pain (EndoCheck)
NCT05245695Endometriosis
Aspira Women's Health
Observational
1,200
Arizona, California, Delaware, Georgia, Indiana, Maryland, New York, Ohio
2022-07-12
Recruiting
Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors
NCT05270213Advanced Cancer
DrugsRBS2418·Pembrolizumab
Riboscience, LLC.
Phase 1
164
Arizona, California, Delaware, Kentucky, Louisiana, Maryland, New York, North Carolina
2022-07-11
Active, closed
HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy
NCT05338970Nonsquamous Non-small Cell Lung Cancer, EGFR L858R, EGFR Exon 19 Deletion
DrugPatritumab deruxtecan
Daiichi Sankyo
Phase 3
586
Alaska, Arkansas, California, Florida, Georgia, Idaho, Maryland, Massachusetts
2022-07-08
Recruiting
Patient Specific Talus Spacer Post Approval Study
NCT05364606Avascular Necrosis of the Talus
Paragon 28
Observational
50
California, Indiana, Maryland, South Carolina, Texas
2022-07-08
Active, closed
A Study of Nipocalimab in Participants With Active Idiopathic Inflammatory Myopathies
NCT05379634Myositis
DrugNipocalimab
Janssen Research & Development, LLC
Phase 2
36
Arizona, California, Florida, Georgia, Kansas, Maryland, Massachusetts, Michigan
2022-07-05
Recruiting
Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)
NCT05354141Acute Respiratory Distress Syndrome, ARDS
Direct Biologics, LLC
Phase 3
970
Arizona, Arkansas, California, District of Columbia, Florida, Idaho, Iowa, Maryland
2022-07-01
Active, closed
(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis
NCT05186753SSM, Mastocytosis, Indolent, Mastocytosis, Systemic, Mastocytosis
DrugBezuclastinib
Cogent Biosciences, Inc.
Phase 2
237
Alabama, Arizona, California, Florida, Georgia, Illinois, Maryland, Massachusetts
2022-06-27
Recruiting
Study Assessing CLENPIQ as Bowel Preparation for Pediatric Colonoscopy
NCT04113382Bowel Preparation
Ferring Pharmaceuticals
Phase 1/2
39
Alabama, California, Maryland
2022-06-23
Recruiting
Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays
NCT05234177Colorectal Cancer
Tempus AI
Observational
300
Arkansas, California, Maryland, Missouri, Nebraska, North Carolina, Ohio, Oklahoma
2022-06-21
Recruiting
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
NCT05142189Non-Small Cell Lung Cancer
DrugsBNT116·Gotistobart·Cemiplimab·Osimertinib
BioNTech SE
Phase 1
320
Kentucky, Maryland, Ohio, Texas, Virginia
2022-06-17
Active, closed
A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma
NCT05283720Non-Hodgkin Lymphoma
DrugsGolcadomide·Epcoritamab·Polatuzumab Vedotin·Doxorubicin Hydrochloride
Genmab
Phase 2
264
Arizona, Connecticut, Delaware, Florida, Georgia, Maryland, Missouri, New York
2022-06-14
Recruiting
A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
NCT05384626Locally Advanced Solid Tumor, Metastatic Solid Tumor
DrugsNeladalkib·Repaglinide·Itraconazole·Midazolam
Nuvalent Inc.
Phase 1/2
840
California, Colorado, District of Columbia, Florida, Georgia, Illinois, Maryland, Massachusetts
2022-06-09
Recruiting
Study of ORIC-944 in Patients With Metastatic Prostate Cancer
NCT05413421Metastatic Prostate Cancer
DrugsDarolutamide (Nubeqa)·Rinzimetostat·Apalutamide (Erleada)
ORIC Pharmaceuticals
Phase 1
275
Colorado, Florida, Illinois, Indiana, Maryland, Michigan, Minnesota, New York
2022-06-01
Recruiting
Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
NCT05379985Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumors
DrugCetuximab
Revolution Medicines, Inc.
Phase 1/2
754
California, Florida, Georgia, Louisiana, Maryland, Massachusetts, New York, Ohio
2022-05-31
Recruiting
Open-label Study of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis (sHLH)
NCT05416307Secondary Hemophagocytic Lymphohistiocytosis (sHLH)
DrugELA026
Electra Therapeutics Inc.
Phase 2/3
156
Alabama, Arizona, California, District of Columbia, Florida, Georgia, Maryland, New York
2022-05-19
Active, closed
A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-remitting Multiple Sclerosis (RRMS)
NCT05123703Relapsing-remitting Multiple Sclerosis
DrugsFingolimod·Ocrelizumab
Hoffmann-La Roche
Phase 3
188
California, Colorado, District of Columbia, Maryland, Massachusetts, Missouri, Ohio, Pennsylvania
2022-05-19
Active, closed
A Study to Assess the Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma Receiving Oral ABBV-453 Tablets
NCT05308654Relapsed/Refractory Multiple Myeloma
DrugsABBV-453·Daratumumab·Lenalidomide·Dexamethasone
AbbVie
Phase 1
34
California, Florida, Louisiana, Maryland, Michigan, Minnesota, New York, North Carolina
2022-05-17
Recruiting
REMASTer: REcurrent Brain Metastases After SRS Trial
NCT05124912Brain Metastases, Radiation Necrosis, Recurrent Tumor, Recurrent Metastases
Monteris Medical
Not applicable
261
California, Illinois, Maryland, Missouri, North Carolina, Ohio, Wisconsin
2022-05-10
By invitation
Posterior Cervical Fixation Study
NCT04770571Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease
NuVasive
Observational
150
California, Connecticut, Maryland, New York, Pennsylvania, Tennessee, Texas
2022-05-10
Active, closed
P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma
NCT04960579Multiple Myeloma
DrugsRimiducid·Methotrexate
Poseida Therapeutics, Inc.
Phase 1
275
Arizona, California, Georgia, Illinois, Iowa, Kansas, Maryland, Michigan
2022-05-05
Recruiting
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
NCT05219617Seizures, Lennox Gastaut Syndrome
SK Life Science, Inc.
Phase 3
252
California, Florida, Idaho, Kentucky, Louisiana, Maryland, Minnesota, Missouri
2022-04-28
Recruiting
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
NCT05061550Non-small Cell Lung Cancer
DrugsAZD0171·Pemetrexed/Cisplatin·Pemetrexed/Carboplatin·Monalizumab
AstraZeneca
Phase 2
630
Arkansas, California, Connecticut, Florida, Georgia, Illinois, Maryland, Massachusetts
2022-04-14
Active, closed
CONVERGE Post-Approval Study (PAS)
NCT05393180Chronic Atrial Fibrillation
AtriCure, Inc.
Not applicable
53
California, Connecticut, Florida, Georgia, Kentucky, Maryland, Massachusetts, New Jersey
2022-04-13
Recruiting
A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies
NCT05131022Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Diffuse Large B Cell Lymphoma (DLBCL), Follicular Lymphoma (FL)
DrugBexobrutideg
Nurix Therapeutics, Inc.
Phase 1
572
California, Colorado, Connecticut, Florida, Georgia, Illinois, Maryland, New York
2022-04-13
Active, closed
Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients
NCT05074810Non Small Cell Lung Cancer, KRAS Activating Mutation
DrugLumakras
Verastem, Inc.
Phase 1/2
153
Colorado, District of Columbia, Illinois, Maryland, Massachusetts, Michigan, Minnesota, Missouri
2022-04-12
Active, closed
Multi-Center Study of ManNAc for GNE Myopathy
NCT04231266GNE Myopathy
Leadiant Biosciences, Inc.
Phase 2
54
California, Iowa, Kansas, Maryland, Massachusetts, Missouri, New York, Ohio
2022-04-05
By invitation
Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With and Without Diabetic Retinopathy
NCT05296447Diabetic Retinopathy, DR
DrugsEylea·Aflibercept
AbbVie
Phase 2
100
Arizona, California, Georgia, Illinois, Maryland, Massachusetts, Nevada, New Jersey
2022-04-04
Active, closed
Olorofim Aspergillus Infection Study
NCT05101187Invasive Aspergillosis
DrugAmbisome
F2G Biotech GmbH
Phase 3
225
Alabama, California, Florida, Georgia, Illinois, Kansas, Maryland, Massachusetts
2022-03-31
Active, closed
Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)
NCT05270668Diffuse Cutaneous Systemic Sclerosis, Interstitial Lung Disease
DrugTulisokibart
Prometheus Biosciences, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 2
154
Arizona, California, Colorado, Connecticut, District of Columbia, Maryland, Massachusetts, Michigan
2022-03-29
Recruiting
4D-710 in Adult Patients With Cystic Fibrosis
NCT05248230Cystic Fibrosis Lung
4D Molecular Therapeutics
Phase 2
30
Alabama, Arizona, California, Colorado, Florida, Illinois, Kansas, Maryland
2022-03-29
Active, closed
A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria
NCT05196035Chronic Kidney Disease, Proteinuria
DrugFinerenone
Bayer
Phase 3
219
California, Florida, Maryland, Missouri, Ohio, Oregon, Utah, Washington
2022-03-28
Active, closed
Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC
NCT05301842Hepatocellular Carcinoma
DrugsTremelimumab·Lenvatinib·Durvalumab
AstraZeneca
Phase 3
760
Alabama, Arizona, California, Georgia, Maryland, New Mexico, New York, Tennessee
2022-03-28
Active, closed
Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)
NCT05348577Prostate Cancer
DrugsCapivasertib·Docetaxel
AstraZeneca
Phase 3
1,035
Arizona, California, Colorado, Maryland, Minnesota, New Jersey, New York, Ohio
2022-03-25
Recruiting
OssDsign® Spine Registry Study ("Propel")
NCT05329129Degenerative Disc Disease, Spinal Stenosis
OssDsign
Observational
450
California, Connecticut, Florida, Georgia, Illinois, Kentucky, Maryland, Minnesota
2022-03-23
Active, closed
A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)
NCT05239728Carcinoma, Renal Cell
DrugsBelzutifan·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,800
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Indiana, Maryland
2022-03-15
By invitation
Global Utilization And Registry Database for Improved preservAtion of doNor Livers
NCT05082077Liver Diseases, Liver Dysfunction, Liver Transplant Disorder, Liver Transplant Rejection
Paragonix Technologies
Observational
2,000
Alabama, California, Florida, Georgia, Maryland, Massachusetts, Nebraska, North Carolina
2022-03-15
Active, closed
Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC)
NCT05280470Extensive-stage Small-cell Lung Cancer
DrugIfinatamab Deruxtecan
Daiichi Sankyo
Phase 2
187
Arkansas, Florida, Illinois, Maryland, Massachusetts, Michigan, Missouri, New Jersey
2022-03-09
Recruiting
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
NCT05261139COVID-19
DrugsNirmatrelvir·Ritonavir
Pfizer
Phase 3
160
Arizona, California, District of Columbia, Florida, Georgia, Illinois, Louisiana, Maryland
2022-03-07
Active, closed
A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer
NCT05132582HER2 Positive Breast Cancer
DrugsPerjeta·Tucatinib·Herceptin·Pertuzumab
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
654
Arizona, Arkansas, California, Florida, Georgia, Illinois, Kentucky, Maryland
2022-03-07
Active, closed
Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations
NCT05215340Metastatic Non Small Cell Lung Cancer
DrugsDato-DXd·Keytruda·Pembrolizumab
Daiichi Sankyo
Phase 3
740
Arizona, California, Colorado, Maryland, Massachusetts, New Hampshire, New Jersey, New York
2022-03-04
Active, closed
A Multicenter Study of Continued Current Therapy vs Transition to Ofatumumab After Neurofilament (NfL) Elevation
NCT05090371Relapsing-Remitting Multiple Sclerosis
DrugOfatumumab
Novartis Pharmaceuticals
Phase 4
136
Alabama, Arizona, California, Florida, Idaho, Louisiana, Maryland, Massachusetts
2022-03-02
Recruiting
Inappropriate Sinus Tachycardia Registry
NCT05107635Inappropriate Sinus Tachycardia, Postural Tachycardia Syndrome
AtriCure, Inc.
Observational
500
California, Florida, Kansas, Maryland, Ohio, Texas, Utah, Washington
2022-03-01
Active, closed
A Phase 3 Single-Arm Study of UGN-102 for Treatment of Low-Grade Intermediate-Risk Non-Muscle Invasive Bladder Cancer
NCT05243550Bladder Cancer, Urothelial Carcinoma, Urothelial Carcinoma Bladder
UroGen Pharma Ltd.
Phase 3
240
Arizona, California, Kansas, Maryland, Missouri, New Jersey, New York, Tennessee
2022-03-01
Active, closed
A Study to Investigate Faricimab Treatment Response in Treatment-Naive, Underrepresented Patients With Diabetic Macular Edema
NCT05224102Diabetic Macular Edema
DrugsVabysmo·Faricimab
Genentech, Inc.
Phase 4
218
Arizona, California, Colorado, District of Columbia, Florida, Illinois, Maryland, Michigan
2022-02-28
Recruiting
A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)
NCT04988555Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Acute, Multiple Myeloma, Myelodysplastic Syndromes
DrugsAzoles·Gilteritinib·Azacitidine·Venetoclax
Sumitomo Pharma America, Inc.
Phase 1/2
606
California, Colorado, District of Columbia, Florida, Illinois, Maryland, Massachusetts, New Jersey
2022-02-28
Active, closed
A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour Resection
NCT05120349Non-Small Cell Lung Cancer
DrugsTagrisso·Osimertinib
AstraZeneca
Phase 3
390
Alaska, California, Colorado, Delaware, Georgia, Illinois, Maryland, New Jersey
2022-02-21
Active, closed
A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC
NCT05211895Non-Small Cell Lung Cancer
DrugsDomvanalimab·Durvalumab
AstraZeneca
Phase 3
791
Arizona, California, District of Columbia, Florida, Georgia, Illinois, Kentucky, Maryland
2022-02-18
Active, closed
A Masked, Placebo-controlled Study to Assess Iptacopan in Age-related Macular Degeneration
NCT05230537Age-Related Macular Degeneration
DrugIptacopan
Novartis Pharmaceuticals
Phase 2
168
California, Colorado, Florida, Indiana, Louisiana, Maryland, Massachusetts, New Jersey
2022-02-17
Active, closed
P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid Tumors
NCT05239143Breast Cancer, Ovarian Cancer, Non Small Cell Lung Cancer, Colorectal Cancer
DrugRimiducid
Poseida Therapeutics, Inc.
Phase 1
180
California, Colorado, Iowa, Kansas, Maryland, Massachusetts, Nebraska, New York
2022-02-15
Active, closed
A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema
NCT05121376Hereditary Angioedema, HAE
BioMarin Pharmaceutical
Phase 1/2
44
Alabama, Arizona, California, Colorado, Kansas, Maryland, Mississippi, Missouri
2022-02-15
Recruiting
Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
NCT05263206Pruritus
DrugsFexofenadine·Dupilumab
Sanofi
Phase 3
284
California, District of Columbia, Florida, Georgia, Indiana, Kentucky, Louisiana, Maryland
2022-02-15
Recruiting
First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies
NCT05627960Triple Negative Breast Cancer, Hormone-Resistant Breast Cancer, Non Small Cell Lung Cancer, Mesothelioma
A&G Pharmaceutical Inc.
Phase 1
77
Maryland
2022-02-14
Active, closed
177Lu-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer
NCT05204927Metastasis From Malignant Tumor of Prostate
DrugEnzalutamide
Curium US LLC
Phase 3
439
Arizona, California, Florida, Illinois, Maryland, Michigan, Minnesota, Missouri
2022-02-14
Active, closed
Optilume PoST AppRoval Clinical Evaluation of Andrology ParaMeters
NCT05383274Urethral Stricture
Urotronic Inc.
Phase 4
34
Arkansas, Florida, Louisiana, Maryland, Nevada, New Jersey, New York, Texas
2022-02-14
Active, closed
A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)
NCT05031780Sickle Cell Disease
DrugMitapivat
Agios Pharmaceuticals, Inc.
Phase 2/3
286
California, Connecticut, District of Columbia, Florida, Illinois, Indiana, Louisiana, Maryland
2022-02-11
Recruiting
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)
NCT04779320Crohn's Disease (CD)
DrugVedolizumab
Takeda
Phase 3
120
Arizona, California, Florida, Georgia, Illinois, Indiana, Maryland, Massachusetts
2022-02-10
Active, closed
A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer
NCT05221840Non-Small Cell Lung Cancer
DrugsMonalizumab·Oleclumab·Durvalumab
AstraZeneca
Phase 3
1,051
California, Connecticut, Florida, Illinois, Indiana, Kentucky, Maryland, Michigan
2022-02-07
Active, closed
A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Disease (MOGAD)
NCT05063162Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD)
DrugRozanolixizumab
UCB Biopharma SRL
Phase 3
113
Arizona, California, Colorado, District of Columbia, Florida, Illinois, Maryland, Massachusetts
2022-02-02
Active, closed
Post Approval Study2: Hintermann Series H3 Total Ankle Replacement System
NCT04770870Osteoarthritis Ankle, Post-Traumatic Osteoarthritis of Ankle, Osteoarthritis of Ankle Secondary to Inflammatory Arthritis (Disorder)
DT MedTech, LLC
Not applicable
94
Arkansas, California, Florida, Indiana, Maryland, New Mexico, North Carolina, Oklahoma
2022-02-01
Active, closed
A Study of Anvumetostat in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)
NCT05094336Advanced MTAP-null Solid Tumors
DrugsAnvumetostat·Docetaxel
Amgen
Phase 1/2
329
California, Florida, Indiana, Maryland, Michigan, Missouri, New Jersey, New York
2022-02-01
Active, closed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)
NCT05262023Frontotemporal Dementia
Denali Therapeutics Inc.
Phase 1/2
85
California, Maryland, Pennsylvania
2022-02-01
Recruiting
A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
NCT05150691HER2-positive Advanced Solid Tumor
DrugsDB-1303/BNT323·Ritonavir·Itraconazole·Pertuzumab
DualityBio Inc.
Phase 1/2
796
California, District of Columbia, Florida, Georgia, Hawaii, Illinois, Louisiana, Maryland
2022-01-31
Active, closed
Tumor-induced Osteomalacia Disease Monitoring Program
NCT04783428Tumor-induced Osteomalacia (TIO)
Ultragenyx Pharmaceutical Inc
Observational
23
Connecticut, Indiana, Maryland, Tennessee, Virginia
2022-01-31
Recruiting
Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
NCT05098132Advanced Solid Tumor, Non Small Cell Lung Cancer, Untreated Advanced NSCLC, 1st Line NSCLC
DrugsPembrolizumab KEYTRUDA·Pemetrexed·Carboplatin
Synthekine
Phase 1/2
364
Arizona, California, Connecticut, District of Columbia, Georgia, Illinois, Maryland, Massachusetts
2022-01-25
Recruiting
Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia
NCT05184335Schizophrenia
Reviva Pharmaceuticals
Phase 3
690
Arizona, Arkansas, California, Florida, Georgia, Illinois, Maryland, Massachusetts
2022-01-24
Recruiting
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
NCT05139017DLBCL, Diffuse Large B-Cell Lymphoma
DrugsZilovertamab vedotin·Granulocyte Colony-Stimulating Factor·Riabni·Ruxience
Merck Sharp & Dohme LLC
Phase 2/3
290
Arizona, California, Florida, Illinois, Kentucky, Maryland, Massachusetts, Michigan
2022-01-14
Recruiting
Myriad™ Augmented Soft Tissue Reconstruction Registry
NCT05243966Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection, Lower Extremity Wound, Pilonidal Sinus
Aroa Biosurgery Limited
Observational
800
Arizona, California, Florida, Georgia, Iowa, Louisiana, Maryland, New York
2022-01-10
Active, closed
Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures
NCT05067634Partial Epilepsy
SK Life Science, Inc.
Phase 3
140
Arizona, California, Connecticut, Georgia, Maryland, Minnesota, New Jersey, New York
2022-01-10
Active, closed
A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
NCT05071300Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
DrugEplontersen
Ionis Pharmaceuticals, Inc.
Phase 3
151
Arizona, Indiana, Maryland, Massachusetts, New York, North Carolina, Oregon, Washington
2022-01-04
Active, closed
Early Phase Clinical Trial About Therapeutic Biological Product Mix for Treating CEA Positive Rectal Cancer
NCT02403505Rectal Cancer
DrugBCG Vaccine Mix for percutaneous use
Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair
Phase 1
20
Maryland
2021-12-28
By invitation
Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD
NCT05210803Neovascular Age-Related Macular Degeneration (nAMD)
DrugsLucentis·Ranibizumab
AbbVie
Phase 2
116
Arizona, California, Georgia, Maryland, Massachusetts, Minnesota, Nevada, New Mexico
2021-12-20
Active, closed
Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
NCT05123755Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral
Vasomune Therapeutics, Inc.
Phase 2
60
California, Colorado, Illinois, Maryland, Michigan, Ohio
2021-12-20
Active, closed
CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer
NCT05210283Colorectal Cancer
Exact Sciences Corporation
Observational
1,017
California, Florida, Illinois, Iowa, Kansas, Maryland, Minnesota, Missouri
2021-12-15
Active, closed
Prospective Case Collection Study for New Mammography Technologies
NCT05199701Mammography
Hologic, Inc.
Not applicable
7,500
Arizona, Florida, Kentucky, Maryland, Michigan, New York, North Carolina, Ohio
2021-12-10
Recruiting
4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
NCT05197270Neovascular (Wet) Age-Related Macular Degeneration
DrugsAflibercept IVT·4D-150 IVT
4D Molecular Therapeutics
Phase 1/2
215
Arizona, California, Colorado, Florida, Illinois, Indiana, Maryland, Massachusetts
2021-12-09
Active, closed
PATHFINDER 2: A Multi-Cancer Early Detection Study
NCT05155605Early Detection of Cancer, Cancer
GRAIL, Inc.
Not applicable
35,883
California, Colorado, District of Columbia, Florida, Georgia, Illinois, Louisiana, Maryland
2021-12-08
Active, closed
Bicalutamide Implants (Biolen) With Radiation Therapy in Patients With Localized Prostate Cancer
NCT04943536Prostate Adenocarcinoma
DrugBicalutamide
Alessa Therapeutics Inc.
Phase 1
20
Maryland
2021-12-07
By invitation
Extension Study of Infigratinib in Children With Achondroplasia (ACH)
NCT05145010Achondroplasia
DrugInfigratinib
QED Therapeutics, a BridgeBio company
Phase 2
300
California, Colorado, Delaware, Maryland, Missouri, Ohio, Tennessee, Wisconsin
2021-12-06
Recruiting
A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine
NCT05164172Migraine
DrugEptinezumab
H. Lundbeck A/S
Phase 3
600
Connecticut, Florida, Kentucky, Maryland, Michigan, New York, North Carolina, Ohio
2021-12-01
Recruiting
A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult Participants With Advanced Prostate Cancer
NCT05125016Metastatic Castration-resistant Prostate Cancer
DrugsNezastomig·REGN4336
Regeneron Pharmaceuticals
Phase 1/2
228
California, Connecticut, Kentucky, Maryland, New Jersey, New York, North Carolina, Ohio
2021-11-30
Active, closed
Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas
NCT04924608Neurofibromatosis 1, Plexiform Neurofibroma (PN)
DrugSelumetinib
AstraZeneca
Phase 3
145
Florida, Maryland, Missouri, New York
2021-11-19
Recruiting
Knee Related Subchondral Bone Lesions Treated With IOBP
NCT05314608Subchondral Cyst
Arthrex, Inc.
Observational
100
Colorado, Florida, Maryland, Ohio, Pennsylvania
2021-11-17
Active, closed
A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders
NCT05112861Age-Related Macular Degeneration, Neovascular Age-related Macular Degeneration, Wet Macular Degeneration, BRVO - Branch Retinal Vein Occlusion
DrugBevacizumab
Outlook Therapeutics, Inc.
Phase 3
120
Illinois, Maryland, Pennsylvania
2021-11-15
Active, closed
A Study of NDI 1150-101 in Patients With Solid Tumors
NCT05128487Solid Tumor, Renal Cell Carcinoma (Kidney Cancer), Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma, Non-Small Cell Lung Cancer
DrugPembrolizumab
Nimbus Saturn, Inc.
Phase 1/2
106
Arizona, Connecticut, District of Columbia, Florida, Kentucky, Maryland, Michigan, Minnesota
2021-11-05
Active, closed
Cinrebafusp Alfa in Combination With Ramucirumab and Paclitaxel in HER2-High Gastric or GEJ Adenocarcinoma and in Combination With Tucatinib in HER2-Low Gastric or GEJ Andenocarinoma
NCT05190445HER2-positive Gastric Cancer
DrugsRamucirumab and paclitaxel·Tucatinib
Pieris Pharmaceuticals, Inc.
Phase 2
80
California, Maryland, New York, Texas
2021-11-01
Recruiting
Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT
NCT04862468Thrombosis, Deep Vein, Iliofemoral; Thrombosis
Mercator MedSystems, Inc.
Phase 2
80
Arizona, California, Connecticut, Florida, Georgia, Louisiana, Maryland, New Jersey
2021-10-29
Active, closed
AlloSure Lung Assessment and Metagenomics Outcomes Study
NCT05050955Lung Transplant Infection, Lung Transplant; Complications, Lung Transplant Failure and Rejection
CareDx
Observational
550
Alabama, Arizona, California, Colorado, Florida, Illinois, Kentucky, Maryland
2021-10-29
Active, closed
A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations
NCT05048797Locally Advanced or Metastatic Non-Small Cell Lung Cancer
DrugsTrastuzumab deruxtecan·Pemetrexed·Cisplatin·Carboplatin
AstraZeneca
Phase 3
454
Alaska, California, Maryland, Massachusetts, Michigan, New Jersey, New York, Pennsylvania
2021-10-28
Active, closed
Pyrocarbon Clinical Follow-up Study
NCT05049993Osteoarthritis of the Shoulder, Avascular Necrosis, Traumatic Arthritis
Stryker Trauma and Extremities
Observational
76
Colorado, Florida, Louisiana, Maryland, Minnesota, Missouri, North Carolina, Oregon
2021-10-27
Active, closed
A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma
NCT04712097Relapsed or Refractory Follicular Lymphoma
DrugsMosunetuzumab·Lenalidomide·Rituximab
Hoffmann-La Roche
Phase 3
478
California, Georgia, Indiana, Maryland, Michigan, Missouri, New York, North Carolina
2021-10-27
Recruiting
Study of KITE-363 or KITE-753 in Participants With Relapsed and/or Refractory B-cell Lymphoma
NCT04989803Relapsed and/or Refractory B-cell Lymphoma
DrugsKITE-753·KITE-363·Fludarabine·Cyclophosphamide
Kite, A Gilead Company
Phase 1/2
247
Arizona, California, Florida, Georgia, Illinois, Kentucky, Maryland, Minnesota
2021-10-27
Active, closed
Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants
NCT04988386Amyloid Cardiomyopathy, Transthyretin-Related
DrugAcoramidis
Eidos Therapeutics, a BridgeBio company
Phase 3
389
California, Colorado, Illinois, Maryland, Massachusetts, Minnesota, Missouri, New York
2021-10-27
Active, closed
ARX788 in HER2-positive, Metastatic Breast Cancer Subjects (ACE-Breast-03)
NCT04829604HER2 Positive Metastatic Breast Cancer
DrugARX788
Ambrx, Inc.
Phase 2
72
California, Georgia, Illinois, Kentucky, Maryland, Massachusetts, Missouri, Nebraska
2021-10-26
Recruiting
First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)
NCT05099172Advanced Non-small Cell Lung Cancer, EGFR Mutation, HER2 Mutation
Bayer
Phase 1/2
400
Arizona, California, Georgia, Maryland, Massachusetts, Michigan, New York, Tennessee
2021-10-25
Active, closed
Osteosarcoma Maintenance Therapy With OST31-164
NCT04974008Bone Cancer
Emerald Clinical Inc.
Phase 2
39
California, Colorado, Connecticut, Delaware, Florida, Georgia, Illinois, Maryland
2021-10-21
Recruiting
ConsideRAte Study - Splenic Stimulation for RA
NCT05003310Rheumatoid Arthritis
DrugBaricitinib
Galvani Bioelectronics
Not applicable
28
Alabama, California, Maryland, New York, Oregon, Pennsylvania, Texas
2021-10-19
Recruiting
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
NCT05123482Breast Cancer, Biliary Tract Carcinoma, Ovarian Cancer, Endometrial Cancer
DrugsPalacaparib·Saruparib·Rilvegostomig
AstraZeneca
Phase 1/2
460
California, Louisiana, Maryland, Massachusetts, Missouri, New Mexico, New York, North Carolina
2021-10-18
By invitation
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs
NCT04930289Interstitial Lung Disease, COPD, Cystic Fibrosis, Pulmonary Fibrosis
Paragonix Technologies
Observational
3,500
Arizona, California, Florida, Maryland, Massachusetts, New York, North Carolina, Pennsylvania
2021-10-15
Active, closed
A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)
NCT04895696Systemic Lupus Erythematosus
Beeline Medicines Corporation
Phase 2
248
Alabama, California, Florida, Georgia, Illinois, Kentucky, Louisiana, Maryland
2021-10-11
Recruiting
STRIVE Post-Market Registry Study
NCT04302272Emphysema
Olympus Corporation of the Americas
Observational
150
Arizona, California, Florida, Illinois, Louisiana, Maryland, Massachusetts, Mississippi
2021-10-09
Active, closed
SARS-CoV-2 Vaccine (GEO-CM04S1) Versus mRNA SARS-COV-2 Vaccine in Patients With Blood Cancer
NCT04977024COVID-19 Infection, Hematopoietic and Lymphoid System Neoplasm, Leukemia, Lymphoma
DrugCOVID-19 Vaccine
GeoVax, Inc.
Phase 2
63
California, Maryland, Massachusetts, New York, North Carolina, Washington
2021-09-27
Active, closed
Study of INBRX-109 in Conventional Chondrosarcoma
NCT04950075Conventional Chondrosarcoma
DrugINBRX-109
Inhibrx Biosciences, Inc
Phase 2
206
Arizona, California, Colorado, Connecticut, Florida, Illinois, Iowa, Maryland
2021-09-23
Recruiting
Innovations in Genicular Outcomes Registry
NCT05495334Knee Osteoarthritis
Pacira Pharmaceuticals, Inc
Observational
10,000
Arizona, California, Florida, Louisiana, Maryland, Massachusetts, Nebraska, New Jersey
2021-09-23
Recruiting
A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy
NCT04557462Primary IgA Nephropathy
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
540
Arizona, California, Colorado, Delaware, Idaho, Illinois, Maryland, Massachusetts
2021-09-20
Active, closed
A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
NCT04965493Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsRiabni·Ruxience·Truxima·Pirtobrutinib
Loxo Oncology, Inc.
Phase 3
600
Arizona, California, Connecticut, Florida, Iowa, Kentucky, Maryland, Massachusetts
2021-09-20
Active, closed
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
NCT04909801Rheumatoid Arthritis
DrugsAbatacept·Humira·Adalimumab·Methotrexate
Bristol-Myers Squibb
Phase 3
338
California, Colorado, Maryland, Minnesota, New Jersey, New York, North Carolina, Oregon
2021-09-15
Active, closed
A Study to Evaluate Chemotherapy Plus Osimertinib Against Chemotherapy Plus Placebo in Patients With Non-small Cell Lung Cancer (NSCLC)
NCT04765059Non-small Cell Lung Cancer
DrugCarboplatin
AstraZeneca
Phase 3
98
Maryland, Massachusetts
2021-09-12
Active, closed
Study of Selinexor Plus DRd for Newly Diagnosed Multiple Myeloma
NCT04782687Multiple Myeloma, Myeloma Multiple, Kahler Disease, Myeloma, Plasma Cell
DrugsDarzalex·Selinexor·Daratumumab·Lenalidomide
US Oncology Research
Phase 2
73
Arizona, Colorado, Maryland, New York, Oregon, Texas, Virginia
2021-09-10
Recruiting
ZEN003694 and Enzalutamide Versus Enzalutamide Monotherapy in Metastatic Castration-Resistant Prostate Cancer
NCT04986423Metastatic Castration-Resistant Prostate Cancer
DrugsZEN003694·Xtandi·Enzalutamide
Zenith Epigenetics
Phase 2
200
California, Colorado, Florida, Louisiana, Maryland, Michigan, New York, North Carolina
2021-09-08
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Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 6 October 2026. https://priyalifescience.com/clinical-trials-usa/state/maryland?page=2

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,118 studies in total at the last sync on 06 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,268 of those studies with a site in Maryland.

How many clinical trials are recruiting in Maryland?

648 of the 1,268 studies on this page are recruiting new participants as of the 06 Oct 2026, 03:16 UTC sync. A further 34 have not yet opened recruitment, 545 are active but closed to new participants, and 41 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.