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Priya Life Science Compound trial record
Compound · clinical trials

RMC-9805 clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 4 trials in our USA, Germany, France, Spain, Italy, Netherlands, Denmark, Austria, Czechia, South Korea, Taiwan and Australia registers that name RMC-9805 as an intervention. Synced 10 Nov 2026
4Current trials
4Recruiting now
2Lead sponsors
12Country registers
At a glance

RMC-9805 is named as an intervention in 4 current clinical trials in our USA, Germany, France, Spain, Italy, Netherlands, Denmark, Austria, Czechia, South Korea, Taiwan and Australia registers. 4 are recruiting patients now. The most common phase is Phase 1/2. The sponsor with the most trials is Revolution Medicines, Inc (3). The most-studied condition is PDAC. The EU clinical trials register (CTIS) separately lists 3 authorised or ongoing trials, 1 with a site in Ireland.

Patient leaflets for RMC-9805

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting4100%

Trials by phase

  • Phase 1/2375%
  • Phase 1125%
01

Clinical trials of RMC-9805

4 trials
StudyPhaseStatusLead sponsorRegisters
Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC
NCT06162221 · Non-Small Cell Lung Cancer, NSCLC, KRAS, NRAS, HRAS-mutated NSCLC, KRAS G12C-mutated Solid Tumors, Lung Cancer
Phase 1/2 Recruiting Revolution Medicines, Inc USA, Germany, France, Spain, Italy, Netherlands, Denmark, Austria, Czechia, South Korea, Taiwan, Australia
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
NCT06445062 · Colorectal Cancer, CRC, Pancreatic Ductal Adenocarcinoma
Phase 1/2 Recruiting Revolution Medicines, Inc USA
Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients
NCT06922591 · PDAC, PDAC - Pancreatic Ductal Adenocarcinoma, NSCLC
Phase 1/2 Recruiting Tango Therapeutics, Inc USA
Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06040541 · Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC)
Phase 1 Recruiting Revolution Medicines, Inc USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

RMC-9805 in the EU trials register (CTIS)

3 trials · 1 in Ireland

Authorised or ongoing trials in the EU Clinical Trials Information System that list a product containing RMC-9805. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.

StudyPhaseStatusSponsorCountries
A Phase 1/2 Open-Label, Multicenter Study of RAS(ON) inhibitors in Combination with Ivonescimab with or without Other Anti-Cancer Agents in Patients with Solid Tumors
2025-524623-50-00 · Neoplasms
Phase 1 Ongoing Revolution Medicines Inc Ireland + 8 more
A Phase 3, Randomized, Open-Label Study of Zoldonrasib (RMC-9805) Plus Daraxonrasib (RMC-6236) Versus Gemcitabine and Nab-Paclitaxel as First-Line Treatment in Patients with Metastatic KRAS G12D-Mutated Pancreatic Adenocarcinoma (RASolute 309)
2025-524969-24-00 · CTIS ↗ · Neoplasms
Phase 3 Authorised Revolution Medicines Inc Austria, Netherlands, Germany + 6 more
A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Investigator Choice of Chemotherapy (modified FOLFIRINOX or Gemcitabine plus Nab-paclitaxel) with or without Zoldonrasib (RMC-9805) as First-line Treatment in Patients with Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma (RASolute 305)
2025-524928-21-00 · Neoplasms
Phase 3 Ongoing Revolution Medicines Inc Sweden, Spain, France + 9 more
03

Conditions studied with RMC-9805

15 conditions
PDAC2Non-small Cell Lung Cancer (NSCLC)1Colorectal Cancer (CRC)1Pancreatic Ductal Adenocarcinoma (PDAC)1Advanced Solid Tumors1PDAC - Pancreatic Ductal Adenocarcinoma1NSCLC1RAS Mutation1Non-Small Cell Lung Cancer, NSCLC1KRAS, NRAS, HRAS-mutated NSCLC1KRAS G12C-mutated Solid Tumors, Lung Cancer1Lung Cancer Stage IV, Advanced Solid Tumor, Cancer1
All 15 conditions
Condition (as registered)Trials
PDAC2
Non-small Cell Lung Cancer (NSCLC)1
Colorectal Cancer (CRC)1
Pancreatic Ductal Adenocarcinoma (PDAC)1
Advanced Solid Tumors1
PDAC - Pancreatic Ductal Adenocarcinoma1
NSCLC1
RAS Mutation1
Non-Small Cell Lung Cancer, NSCLC1
KRAS, NRAS, HRAS-mutated NSCLC1
KRAS G12C-mutated Solid Tumors, Lung Cancer1
Lung Cancer Stage IV, Advanced Solid Tumor, Cancer1
Colorectal Cancer1
CRC1
Pancreatic Ductal Adenocarcinoma1
04

Sponsors

lead sponsor per trial
Lead sponsorTrials
Revolution Medicines, Inc3
Tango Therapeutics, Inc1
05

By country register

RegisterTrialsRecruiting
Clinical trials in USA44
Clinical trials in Germany11
Clinical trials in France11
Clinical trials in Spain11
Clinical trials in Italy11
Clinical trials in Netherlands11
Clinical trials in Denmark11
Clinical trials in Austria11
Clinical trials in Czechia11
Clinical trials in South Korea11
Clinical trials in Taiwan11
Clinical trials in Australia11
EU register (CTIS)3—

A trial with sites in more than one country appears in each of those registers. CTIS does not publish a recruiting flag; its trials may also appear in the registers above.

06

Related compounds

07

Questions about RMC-9805 trials

How many clinical trials are testing RMC-9805?

4 current trials in our USA, Germany, France, Spain, Italy, Netherlands, Denmark, Austria, Czechia, South Korea, Taiwan and Australia registers name RMC-9805 as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.

Are RMC-9805 trials recruiting patients?

Yes. 4 of the 4 trials are recruiting: 4 with sites in USA, 1 with sites in Germany, 1 with sites in France, 1 with sites in Spain, 1 with sites in Italy, 1 with sites in Netherlands, 1 with sites in Denmark, 1 with sites in Austria, 1 with sites in Czechia, 1 with sites in South Korea, 1 with sites in Taiwan and 1 with sites in Australia. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors RMC-9805 clinical trials?

Revolution Medicines, Inc (3) and Tango Therapeutics, Inc (1). The number in brackets is how many trials each organisation leads.

Are there RMC-9805 clinical trials in Ireland?

Yes. 1 trial in the EU register (CTIS) list a site in Ireland. Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how RMC-9805 works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how RMC-9805 works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists RMC-9805 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.