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Clinical Trials in the USA / NCT06040541
Recruiting Phase 1

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

NCT06040541 · tracked via the Priya Life Science USA tracker
Sponsor
Revolution Medicines, Inc.
Phase
Phase 1
Started
2023-09-07
Last updated
2026-06-03

Condition(s) studied

Non-small Cell Lung Cancer (NSCLC)Colorectal Cancer (CRC)Pancreatic Ductal Adenocarcinoma (PDAC)Advanced Solid Tumors

Investigational drug(s) / intervention(s)

RMC-9805RMC-6236

RMC-9805: Oral Tablets

RMC-6236: Oral Tablets

Study summary

This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Pathologically documented, locally advanced or metastatic solid tumor with a KRAS G12D-mutation * Received and progressed or been intolerant to prior standard therapy (including targeted therapy) appropriate for tumor type and stage * ECOG performance status 0 or 1 * Adequate organ function Exclusion Criteria: * Primary central nervous system (CNS) tumors * Known or suspected leptomeningeal or active brain metastases or spinal cord compression * Known or suspected impairment of gastrointestinal function that may prohibit ability to swallow or absorb an oral medication * Participant was previously treated with an investigational KRAS G12D inhibitor, pan- or multi-RAS inhibitor, or had prior therapy with any direct RAS-targeted therapy (eg, degraders and inhibitors) Other inclusion/exclusion criteria may apply.

Primary outcome measure(s)

Trial sites (17)

FacilityCityRegionStatus
University of California, Davis Comprehensive Cancer Center Sacramento California Recruiting
Smilow Cancer Hospital (Yale University) New Haven Connecticut Recruiting
Florida Cancer Specialists Sarasota Florida Recruiting
Lee Moffitt Cancer Center Tampa Florida Recruiting
Johns Hopkins University Baltimore Maryland Recruiting
Massachusetts General Hospital Boston Massachusetts Recruiting
Dana-Farber Cancer Institute Boston Massachusetts Recruiting
NYU Langone New York New York Recruiting
Memorial Sloan Kettering Cancer Center New York New York Recruiting
Duke Cancer Center Durham North Carolina Recruiting
Carolina BioOncology Institute Huntersville North Carolina Recruiting
The Christ Hospital Cincinnati Ohio Recruiting
Sarah Cannon Research Institute Nashville Tennessee Recruiting
Sarah Cannon Research Institute at Mary Crowley Dallas Texas Recruiting
University of Texas, MD Anderson Cancer Center Houston Texas Recruiting
START San Antonio Texas Recruiting
NEXT Oncology Virginia Fairfax Virginia Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06040541 on ClinicalTrials.gov ↗ ← All trials in the USA