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Trackers› Clinical trials› Pennsylvania
Clinical trial register · United States · industry-sponsored

Clinical Trials in Pennsylvania, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9118 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 06 Oct 2026, 03:16 UTC
9118
Studies in scope
industry-sponsored, all four open statuses
4945
Recruiting now
open to new participants
2189
Lead sponsors
across recruiting studies
Top states
California 5290 Florida 4430 Illinois 2481 Georgia 2368 Arizona 2238
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
AstraZeneca33 Novartis Pharmaceuticals29 Merck Sharp & Dohme LLC20 Eli Lilly and Company18 Janssen Research & Development, LLC17
State
California5290 Florida4430 Illinois2481 Georgia2368 Arizona2238
All 51 states
Target enrolment
to

Trials with a site in Pennsylvania

1048 of 9118 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Recruiting
Safety, Pharmacokinetics (PK), and Efficacy of ONC 841 in Advanced Solid Tumors
NCT06352359Advanced Solid Tumor
OncoC4, Inc.
Phase 1
72
California, Florida, Kentucky, Michigan, Pennsylvania, Texas, Utah
2024-08-23
Recruiting
Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
NCT06535607Sub-study 1 Cervical Cancer (Volrustomig Monotherapy), Sub-study 2 Head and Neck Squamous Cell Carcinoma (Volrustomig Monotherapy), Sub-study 3 Head and Neck Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy), Sub-study 4 Esophageal Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy)
DrugsVolrustomig·Adrucil·Paclitaxel·Cisplatin
AstraZeneca
Phase 2
257
California, Maryland, New York, Ohio, Pennsylvania
2024-08-22
Recruiting
Abbott Structural Heart Device Registry
NCT06590467Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale
Abbott Medical Devices
Observational
2,500
California, District of Columbia, Florida, Missouri, New Jersey, New York, Ohio, Pennsylvania
2024-08-21
Recruiting
Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)
NCT06371417Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP), Behçet's Syndrome (BS), Dermatomyositis (DM)
DrugRAY121
Chugai Pharmaceutical
Phase 1
144
California, Maryland, New York, North Carolina, Ohio, Oregon, Pennsylvania, Texas
2024-08-19
Recruiting
Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis (NEC)
NCT06315738Necrotizing Enterocolitis
Noveome Biotherapeutics, formerly Stemnion
Phase 1/2
36
Arkansas, Connecticut, Florida, Illinois, Oklahoma, Pennsylvania
2024-08-19
Recruiting
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
NCT06546670Sickle Cell Disease
Novartis Pharmaceuticals
Phase 1/2
161
Alabama, Florida, Massachusetts, North Carolina, Pennsylvania, Rhode Island, Texas
2024-08-15
Recruiting
Nafamostat Efficacy in Phase 3 Registrational CRRT Study
NCT06150742Acute Kidney Injury
Talphera, Inc
Not applicable
70
California, Florida, Michigan, New Mexico, New York, Ohio, Pennsylvania, South Carolina
2024-08-15
Recruiting
A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy
NCT05861999Muscular Atrophy, Spinal
DrugRisdiplam
Hoffmann-La Roche
Phase 4
28
Arkansas, California, Colorado, Florida, Georgia, Michigan, Pennsylvania, Texas
2024-08-14
Recruiting
MSC EVs in Dystrophic Epidermolysis Bullosa
NCT04173650Dystrophic Epidermolysis Bullosa
Aegle Therapeutics
Phase 1/2
8
Arizona, California, Pennsylvania
2024-08-13
Recruiting
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
NCT06545942Advanced Solid Tumor, Metastatic Solid Tumor, Prostate Cancer, Pancreas Cancer
DrugOlaparib
MOMA Therapeutics
Phase 1
220
Arizona, California, Florida, Missouri, New York, Pennsylvania, South Carolina, Tennessee
2024-08-13
Recruiting
Melodi Matrix™ in Breast Reconstruction
NCT06027996Breast Reconstruction
Melodi Health, Inc.
Not applicable
702
California, Michigan, Minnesota, New York, Ohio, Pennsylvania, South Carolina, South Dakota
2024-08-09
Recruiting
Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)
NCT06445972Gastroesophageal Junction, Gastroesophageal Adenocarcinoma, Esophageal Neoplasms, Esophageal Cancer
DrugsPatritumab deruxtecan·Ramucirumab·Sacituzumab tirumotecan·Paclitaxel
Merck Sharp & Dohme LLC
Phase 1/2
210
Arizona, California, Kentucky, Michigan, New York, Pennsylvania, Texas
2024-08-07
Recruiting
A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers
NCT06469281Epithelial Ovarian Cancer, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
DrugsMvasi·Cemiplimab·Avastin·Bevacizumab
Regeneron Pharmaceuticals
Phase 1
90
Massachusetts, New Jersey, New York, Pennsylvania, Utah
2024-08-06
Recruiting
Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS)
NCT06212193Tricuspid Regurgitation, Tricuspid Regurgitation Functional
Innoventric LTD
Not applicable
15
California, Michigan, Minnesota, New York, Ohio, Pennsylvania, Tennessee, Washington
2024-08-05
Recruiting
A Natural History Study of Corneal Abrasions in Patients With Dystrophic Epidermolysis Bullosa (DEB)
NCT06563414Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa Dystrophica, Recessive, Epidermolysis Bullosa Dystrophica Dominans
Krystal Biotech, Inc.
Observational
40
Pennsylvania
2024-08-02
By invitation
Long-term Follow-up of Gene Therapy for Radiation-Induced Xerostomia
NCT06544798Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
MeiraGTx, LLC
Phase 2
276
Arizona, Florida, Iowa, Missouri, New York, North Carolina, Pennsylvania
2024-08-02
Recruiting
Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC
NCT05733598Hepatocellular Carcinoma, Biliary Tract Cancer
DrugsRP2·Tecentriq·Avastin·Atezolizumab
Replimune, Inc.
Phase 2
60
California, Florida, Maryland, New York, Pennsylvania, Tennessee, Texas
2024-08-01
Active, closed
A Phase 2/3 Study to Evaluate the Efficacy and Safety of Tinlarebant in Subjects With Stargardt Disease
NCT06388083STGD1, Stargardt Disease 1
DrugTinlarebant
Belite Bio, Inc
Phase 2/3
60
Arizona, California, Florida, Massachusetts, Minnesota, New York, North Carolina, Pennsylvania
2024-07-31
Active, closed
SELVA: A Phase 3 Study Evaluating QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations
NCT06239480Microcystic Lymphatic Malformation
DrugQTORIN rapamycin anhydrous
Palvella Therapeutics, Inc.
Phase 3
51
California, Georgia, Minnesota, New York, North Carolina, Ohio, Pennsylvania, Tennessee
2024-07-31
Active, closed
A Study to Evaluate the Effect of Bimekizumab on Gene Expression Biomarkers in Study Participants With Moderate to Severe Plaque Psoriasis
NCT06506916Moderate to Severe Plaque Psoriasis, Psoriatic Arthritis
DrugBimekizumab
UCB Biopharma SRL
Phase 3
89
Alabama, California, Florida, Michigan, New York, Pennsylvania
2024-07-29
Recruiting
A Phase 1/2 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors
NCT06427941Metastatic Hepatocellular Carcinoma, Local Advanced Hepatocellular Carcinoma, Alpha-fetoprotein (AFP)-Producing Gastric Cancer, Extragonadal Yolk Sac Tumors
DrugsTislelizumab·Bevacizumab
BeOne Medicines
Phase 1/2
630
Alabama, Arizona, California, Illinois, New York, Pennsylvania, Tennessee, Texas
2024-07-23
Recruiting
An Open-label Dose Escalation/Expansion Trial to Evaluate the Safety and Anti-tumor Activity of TEV-56278 Alone or in Combination With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
NCT06480552Advanced Solid Tumors
DrugsTEV-56278·Keytruda·Pembrolizumab
Teva Branded Pharmaceutical Products R&D LLC
Phase 1
240
California, Florida, Illinois, Michigan, North Carolina, Ohio, Pennsylvania, Tennessee
2024-07-22
Recruiting
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
NCT06979323Asthma
DrugDepemokimab
GlaxoSmithKline
Phase 3
150
Florida, Kansas, Missouri, New Jersey, New York, Pennsylvania, Texas
2024-07-19
Recruiting
QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry
NCT06517810Acute Kidney Injury, Acute Kidney Injury Due to Sepsis
SeaStar Medical
Observational
50
Alabama, California, Colorado, Georgia, Illinois, Michigan, Ohio, Pennsylvania
2024-07-19
Recruiting
Modified Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of Hard-to-Heal DFUs
NCT06449638Diabetic Foot Ulcer (DFU), Ulcer Foot, Diabetic Foot, Foot Ulcer
StimLabs
Not applicable
272
Nebraska, Oklahoma, Pennsylvania
2024-07-16
Recruiting
Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT
NCT05399537Regional Citrate Anticoagulation (RCA), Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury (AKI)
Vantive Health LLC
Phase 3
40
Alabama, California, Florida, Georgia, Michigan, Ohio, Pennsylvania, South Carolina
2024-07-12
Active, closed
Study to Assess the Efficacy and Safety of Iovera®° System in Subjects With Upper Extremity Spasticity
NCT06340451Spasticity, Cerebral or Spinal Condition
Pacira Pharmaceuticals, Inc
Not applicable
132
California, Florida, Georgia, Kansas, Missouri, New Jersey, New York, Pennsylvania
2024-07-11
Active, closed
A Trial to Investigate Teprotumumab Subcutaneous Administration Compared With Placebo in Male and Female Adult Participants With Moderate-to-severe Active Thyroid Eye Disease
NCT06248619Thyroid Eye Disease
DrugTeprotumumab
Amgen
Phase 3
89
Arizona, Illinois, Michigan, Nevada, New Jersey, Oregon, Pennsylvania, Tennessee
2024-07-05
Active, closed
A Study to Find Out How BIIB141 (Omaveloxolone) is Processed in the Body and to Learn More About Its Safety in Participants With Friedreich's Ataxia Aged 2 to 15 Years Old
NCT06054893Friedreich Ataxia
DrugsOmaveloxolone·Skyclarys
Biogen
Phase 1
33
Pennsylvania
2024-07-01
Recruiting
A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3)
NCT06263231Sarcoma,Soft Tissue
DrugsINT230-6·Trabectedin·Pazopanib·Eribulin
Intensity Therapeutics, Inc.
Phase 3
333
California, Connecticut, Michigan, Nebraska, North Carolina, Ohio, Pennsylvania
2024-06-28
Active, closed
A Phase 3 Study Of OCU400 Gene Therapy for the Treatment Of Retinitis Pigmentosa
NCT06388200Retinitis Pigmentosa
Ocugen
Phase 3
140
Arizona, California, Florida, Pennsylvania, Tennessee, Texas, Wisconsin
2024-06-18
Recruiting
Transdermal Compress IDE Study
NCT06134167Prosthesis and Implants
Balmoral Medical company
Not applicable
100
California, Colorado, Illinois, Maryland, New York, Ohio, Pennsylvania
2024-06-11
Recruiting
Safety, PK/PD, and Exploratory Efficacy Study of AMT-191 in Classic Fabry Disease
NCT06270316Fabry Disease
UniQure Biopharma B.V.
Phase 1/2
20
Alabama, California, Georgia, Illinois, Minnesota, New York, Ohio, Pennsylvania
2024-06-05
Recruiting
Gleolan for Visualization of Newly Diagnosed or Recurrent Ovarian Cancer (OVA-302)
NCT05804370Ovarian Cancer
DrugGleolan
NX Development Corp
Phase 3
170
Arizona, Florida, Maryland, Minnesota, New York, Ohio, Pennsylvania, Virginia
2024-05-30
Recruiting
A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy
NCT05861986Muscular Atrophy, Spinal
DrugRisdiplam
Hoffmann-La Roche
Phase 4
28
Arkansas, Colorado, Florida, Georgia, Illinois, Michigan, New York, Pennsylvania
2024-05-30
Active, closed
A Study of AMG 732 in Healthy Participants and Participants With Thyroid Eye Disease
NCT06401044Thyroid Eye Disease
DrugAMG 732
Amgen
Phase 1/2
94
Arkansas, California, Florida, Illinois, Massachusetts, Nevada, Pennsylvania, Texas
2024-05-30
Recruiting
First in Human Study of CDR404 in HLA-A*02:01 Participants With MAGE-A4 Expressing Solid Tumors
NCT06402201Select Advanced Solid Tumors
CDR-Life AG
Phase 1
42
Florida, Michigan, Oregon, Pennsylvania
2024-05-24
Recruiting
A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)
NCT06351631Thrombocythemia, Essential, Primary Myelofibrosis, Myelofibrosis, Post-polycythemia Vera Myelofibrosis
DrugBomedemstat
Merck Sharp & Dohme LLC
Phase 3
400
Michigan, North Carolina, Ohio, Pennsylvania
2024-05-23
Active, closed
A Study With L19TNF in Combination With Lomustine in Patients With Glioblastoma at Progression or Recurrence
NCT06336291Glioblastoma
DrugsOnfekafusp alfa·Lomustine
Philogen S.p.A.
Phase 2
90
Illinois, Massachusetts, New York, Pennsylvania, Texas, Virginia
2024-05-22
Active, closed
Short-Term Linvoseltamab Treatment on Top of Chronic Dupilumab Treatment for Adults With Severe Immunoglobulin E (IgE)-Mediated Food Allergy
NCT06369467Food Allergy
DrugsLinvoseltamab·Dupilumab
Regeneron Pharmaceuticals
Phase 1
6
Florida, Georgia, Massachusetts, New York, Pennsylvania
2024-05-17
Recruiting
A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy
NCT06055439Neuroendocrine Tumors, Colorectal Cancer, Gastric Cancer
Chimeric Therapeutics
Phase 1/2
135
Georgia, Illinois, Pennsylvania, Tennessee
2024-05-15
Active, closed
Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care
NCT06422689Asthma
AstraZeneca
Phase 4
1,511
California, Kentucky, Massachusetts, Michigan, Minnesota, North Carolina, Pennsylvania, Texas
2024-05-10
Recruiting
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B or Factor VII Deficiency)
NCT06349473Healthy Participants, Hemophilia A, Hemophilia B, Factor VII Deficiency
DrugSR604
Equilibra Bioscience LLC
Phase 1
31
California, Illinois, Louisiana, Michigan, Missouri, North Carolina, Pennsylvania
2024-05-10
Active, closed
Telerehabilitation Early After CNS Injury
NCT06069999Cerebral Stroke, Traumatic Brain Injury, Spinal Cord Injuries
TRCare, Inc.
Not applicable
60
California, Florida, Pennsylvania, Utah
2024-05-09
Recruiting
A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)
NCT06138639Duchenne Muscular Dystrophy
Solid Biosciences Inc.
Phase 1/2
60
Arkansas, California, Georgia, Illinois, Missouri, Ohio, Oregon, Pennsylvania
2024-05-06
Recruiting
Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab
NCT06249048Advanced Solid Tumor
DrugsKeytruda·Pembrolizumab
Strand Therapeutics Inc.
Phase 1/2
108
Arizona, California, Ohio, Pennsylvania, Texas, Utah
2024-05-03
Recruiting
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
NCT06164730Heterozygous Familial Hypercholesterolemia, Premature Coronary Heart Disease
DrugVERVE-102
Verve Therapeutics, Inc.
Phase 1
85
Alabama, California, Florida, Indiana, North Carolina, Pennsylvania, Texas, Washington
2024-04-30
Recruiting
A Clinical Study of the TSX Dental Implant System (Xpresso)
NCT06571812Tooth Loss
ZimVie
Observational
62
Ohio, Pennsylvania
2024-04-24
By invitation
ACP-204 in Adults With Alzheimer's Disease Psychosis Open Label Extension Study
NCT06194799Alzheimer's Disease Psychosis
DrugACP-204
ACADIA Pharmaceuticals Inc.
Phase 3
752
California, Florida, Pennsylvania, Texas
2024-04-23
Active, closed
Blood Purification for the Treatment of Pathogen Associated Shock
NCT05011656Septic Shock
ExThera Medical Corporation
Not applicable
15
District of Columbia, Georgia, Michigan, Minnesota, Oregon, Pennsylvania, Texas
2024-04-19
Recruiting
Evaluate the Effects of Long-term Use of Psychotropic Medications on Eye Movement Patterns With the Gaize Device
NCT07389473ADHD, Depression Disorders, Mood Disorders, Anxiety Disorder Generalized
Gaize
Observational
50
Pennsylvania
2024-04-17
Recruiting
A Real-world Long-term Safety and Immunogenicity Study of Olipudase Alfa Therapy in Pediatric Patients Less Than 2 Years of Age With Acid Sphingomyelinase Deficiency (ASMD)
NCT06192576Niemann-Pick Diseases, Acid Sphingomyelinase Deficiency
Sanofi
Observational
10
Illinois, Ohio, Pennsylvania, Texas, Utah
2024-04-16
Recruiting
Aptis PRUJ Prosthesis for the Treatment of Patients With Proximal Radial Ulna Joint Disorders.
NCT05796908Arthritis, Unstable Radial Head, Proximal Radioulnar Joint Instability, Decreased Motion at the Proximal Radioulnar Joint and/or the Radio-humeral Joint
Aptis Medical
Not applicable
84
Indiana, Kentucky, Massachusetts, Ohio, Pennsylvania, Wisconsin
2024-04-12
Active, closed
A Study of Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Renal Cell Carcinoma (V940-004).
NCT06307431Renal Cell Carcinoma
DrugsIntismeran autogene·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 2
272
California, Connecticut, Massachusetts, New York, North Carolina, Pennsylvania, Texas
2024-04-10
Recruiting
A Study of JNJ-87704916, as Monotherapy and in Combination for Advanced Solid Tumors
NCT06311578Neoplasms
DrugCetrelimab
Johnson & Johnson Enterprise Innovation Inc.
Phase 1
126
New York, Pennsylvania, Texas
2024-04-10
Recruiting
Orbit Study: A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Intrathecally Administered ION356 in Participants With Pelizaeus Merzbacher Disease (PMD)
NCT06150716Pelizaeus-Merzbacher Disease
Ionis Pharmaceuticals, Inc.
Phase 1
24
Georgia, Pennsylvania, Utah
2024-04-10
Recruiting
A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
NCT06326411Oncology, MEK Mutation, RAF Gene Mutation, Ras (KRAS or NRAS) Gene Mutation
Nested Therapeutics, Inc
Phase 1
230
California, Colorado, Connecticut, Florida, New York, Pennsylvania, Tennessee, Texas
2024-04-09
Active, closed
A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)
NCT06305767Bladder Cancer
DrugsIntismeran autogene·Enfortumab Vedotin·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 1/2
230
California, Florida, Illinois, Iowa, New York, North Carolina, Ohio, Pennsylvania
2024-03-28
Recruiting
A Study of Participants With Cerebral Adrenoleukodystrophy (CALD) Treated With Elivaldogene Autotemcel
NCT06224413Cerebral Adrenoleukodystrophy (CALD)
Genetix Biotherapeutics Inc.
Observational
120
Massachusetts, Pennsylvania, Texas
2024-03-27
Recruiting
Efficacy and Safety Study of OATD-01 in Patients With Active Pulmonary Sarcoidosis
NCT06205121Pulmonary Sarcoidosis
Molecure S.A.
Phase 2
96
Alabama, Kansas, Maryland, Minnesota, Ohio, Pennsylvania, South Carolina
2024-03-21
Recruiting
AETOS Shoulder System
NCT06319911Shoulder Osteoarthritis, Shoulder Arthritis
Smith & Nephew, Inc.
Observational
220
California, Colorado, Georgia, Oregon, Pennsylvania
2024-03-05
Active, closed
An Open-label Extension Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis
NCT06169397Pulmonary Sarcoidosis
Xentria, Inc.
Phase 2
31
Colorado, Illinois, North Carolina, Ohio, Pennsylvania
2024-03-01
Recruiting
SNV1521 in Participants With Advanced Solid Tumors
NCT06220864Advanced Solid Tumor
DrugsDB-1310·Abiraterone·Darolutamide
Synnovation Therapeutics, Inc.
Phase 1
400
Connecticut, Pennsylvania, Tennessee, Texas, Utah
2024-02-23
Active, closed
NS-089/NCNP-02-201 in Boys With Duchenne Muscular Dystrophy (DMD)
NCT05996003Duchenne Muscular Dystrophy, Exon 44, DMD
DrugBrogidirsen
NS Pharma, Inc.
Phase 2
20
Colorado, Georgia, Illinois, Kansas, Massachusetts, New York, Ohio, Pennsylvania
2024-02-22
Active, closed
Persona IQ Cohort Study
NCT06089291Osteo Arthritis Knee, Knee Arthritis, Monitoring Orthopedic Devices, Total Knee Arthroplasty
Zimmer Biomet
Observational
200
Indiana, Missouri, North Carolina, Pennsylvania
2024-02-20
Active, closed
A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1)
NCT06185764Myotonic Dystrophy Type 1 (DM1)
DrugVX-670
Vertex Pharmaceuticals Incorporated
Phase 1/2
47
California, Florida, Kansas, Massachusetts, Missouri, North Carolina, Pennsylvania, Virginia
2024-02-20
Active, closed
A Dose-escalation Clinical Study of Intraoperative Photodynamic Therapy of Glioblastoma
NCT05736406Primary Glioblastoma
Hemerion Therapeutics
Phase 1/2
12
Pennsylvania
2024-02-20
By invitation
An Observational Study of Patients With Chronic Liver Disease
NCT05744713Chronic Liver Disease, Cirrhosis
Target PharmaSolutions, Inc.
Observational
500,000
California, District of Columbia, Illinois, New York, North Carolina, Pennsylvania, Texas
2024-02-19
Recruiting
A Natural History Study in Participants With Congenital Myasthenic Syndromes (CMS) Due to Mutations in DOK7, MUSK, AGRN, or LRP4
NCT06078553Congenital Myasthenic Syndrome
argenx
Observational
100
California, Illinois, Massachusetts, Minnesota, Ohio, Pennsylvania
2024-02-13
Recruiting
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
NCT06244771Advanced Solid Tumors With KRAS G12C Mutations, Solid Tumor, Adult, Unresectable Solid Tumor, Metastatic Solid Tumor
Frontier Medicines Corporation
Phase 1/2
403
California, Florida, Indiana, Kansas, Massachusetts, Michigan, Pennsylvania, Texas
2024-02-12
Recruiting
Study Evaluating INS018_055 Administered Orally to Subjects With Idiopathic Pulmonary Fibrosis
NCT05975983Idiopathic Pulmonary Fibrosis (IPF)
DrugINS018_055
InSilico Medicine Hong Kong Limited
Phase 2
40
Alabama, Arizona, California, Florida, North Carolina, Oklahoma, Pennsylvania, South Carolina
2024-02-08
Active, closed
A Study About Antibody Levels and Biomarkers in the Blood in People With Late-onset Pompe Disease
NCT06150820Pompe Disease (Late-onset)
Astellas Gene Therapies
Not applicable
119
Georgia, Kansas, Michigan, Minnesota, New Jersey, Ohio, Pennsylvania, Utah
2024-02-01
Recruiting
Efficacy and Safety of CSL222 (Etranacogene Dezaparvovec) Gene Therapy in Adults With Hemophilia B With Pretreatment Adeno-associated Virus Serotype 5 (AAV5) Neutralizing Antibodies (Nabs)
NCT06003387Hemophilia B
CSL Behring
Phase 3
35
California, Michigan, Pennsylvania, Texas
2024-01-30
Active, closed
Safety, PK and PD Relationships of RLS-0071 in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
NCT06175065Acute Exacerbation of Chronic Obstructive Pulmonary Disease
DrugRLS-0071
ReAlta Life Sciences, Inc.
Phase 2
24
Florida, Maryland, Nebraska, Pennsylvania
2024-01-25
Recruiting
An Open-Label Study of CTI-1601 in Subjects With Friedreich's Ataxia
NCT06447025Friedreich Ataxia
DrugNomlabofusp
Larimar Therapeutics, Inc.
Phase 2
85
California, Florida, Iowa, Maryland, New Jersey, Ohio, Pennsylvania
2024-01-25
Active, closed
A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy
NCT06112743Cardiomyopathy, Hypertrophic
DrugMavacamten
Bristol-Myers Squibb
Phase 4
63
California, Georgia, Massachusetts, Ohio, Pennsylvania, Texas, Utah
2024-01-24
Recruiting
AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies.
NCT06137144Lymphoma, Non-Hodgkin Lymphoma, Hodgkin Lymphoma, Peripheral T-cell Lymphoma (PTCL)
DrugsAZD3470·Keytruda·Pembrolizumab
AstraZeneca
Phase 1/2
161
California, Florida, Georgia, Massachusetts, New York, Pennsylvania, Texas
2024-01-23
Recruiting
A Study of Participants with Β-Thalassemia Treated with Betibeglogene Autotemcel
NCT06271512Beta-Thalassemia
Genetix Biotherapeutics Inc.
Observational
150
California, Minnesota, New York, Pennsylvania, Texas
2024-01-23
Active, closed
DAREON™-7: A Study to Test How Well Different Doses of BI 764532 in Addition to Chemotherapy Are Tolerated by People With Advanced Neuroendocrine Cancers
NCT06132113Neuroendocrine Neoplasms
DrugsObrixtamig·Etoposide·Cisplatin·Carboplatin
Boehringer Ingelheim
Phase 1
65
Florida, Georgia, Illinois, New Jersey, Pennsylvania
2024-01-22
Recruiting
A Long Term, Post-marketing Study of Immune Response in Patients Receiving Palynziq Treatment for PKU (PALisade)
NCT06305234Phenylketonuria (PKU)
DrugPegvaliase
BioMarin Pharmaceutical
Observational
200
Colorado, Georgia, Illinois, Indiana, Louisiana, Massachusetts, Oregon, Pennsylvania
2024-01-20
Recruiting
A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas
NCT05641844Anal Fistula
RedDress Ltd.
Not applicable
110
California, Florida, Illinois, Indiana, Massachusetts, Minnesota, New York, Pennsylvania
2024-01-20
Active, closed
A Study of AB801 Monotherapy and Combination Therapy in Participants With Advanced Malignancies
NCT06120075Advanced Cancer
DrugDocetaxel
Arcus Biosciences, Inc.
Phase 1
91
Colorado, District of Columbia, Georgia, Michigan, New York, Pennsylvania, Texas, Utah
2024-01-19
Recruiting
Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors
NCT06171750Advanced Solid Tumor, Cutaneous Tumor, Subcutaneous Tumor, Malignant Solid Tumor
DrugsTolododekin alfa·Cemiplimab
Ankyra Therapeutics, Inc
Phase 1
97
Maryland, Massachusetts, Oregon, Pennsylvania
2024-01-19
Recruiting
A Study of AZD3470, a PRMT5 Inhibitor, Given as Monotherapy and in Combination in Patients With MTAP Deficient Advanced/Metastatic Solid Tumors
NCT06130553Advanced Solid Tumors That Are MTAP Deficient
DrugsAZD3470·Dato-DXd
AstraZeneca
Phase 1/2
334
California, Connecticut, Maryland, Oregon, Pennsylvania, Rhode Island, Virginia
2024-01-18
Active, closed
A Trial to Learn More About an Experimental Gene Therapy Called Bidridistrogene Xeboparvovec (SRP-9003) as a Possible Treatment for Limb Girdle Muscular Dystrophy 2E/R4
NCT06246513Limb-girdle Muscular Dystrophy
Sarepta Therapeutics, Inc.
Phase 3
17
California, Ohio, Pennsylvania, Virginia
2024-01-15
Recruiting
Phase I Study to Assess the Safety and Efficacy of OCU200 for Center-Involved Diabetic Macular Edema (DME)
NCT05802329Center Involved Diabetic Macular Edema, Diabetic Macular Edema
Ocugen
Phase 1
24
Florida, Pennsylvania, Texas, Wisconsin
2024-01-13
Active, closed
A Phase II Study of AAA617 Alone and AAA617 in Combination With ARPI in Patients With PSMA PET Scan Positive CRPC
NCT05849298Prostatic Neoplasm
DrugsARPI·Pylarify·Illuccix·Lu-PSMA
Novartis Pharmaceuticals
Phase 2
49
Colorado, Georgia, Indiana, Iowa, Nebraska, Oregon, Pennsylvania, Texas
2024-01-03
Recruiting
Study of CTO1681 for the Prevention and Treatment of CRS in Patients Receiving CAR T-Cell Therapy
NCT05905328Cytokine Release Syndrome
CytoAgents, Inc.
Phase 1/2
54
California, Georgia, Massachusetts, North Carolina, Pennsylvania, Washington
2023-12-28
Recruiting
Study to Evaluate the Safety of CG-P5 Peptide Eye Drops in Patients Diagnosed With Age-related Wet Macular Degeneration
NCT06132035Age-related Wet Macular Degeneration
DrugsEylea·Aflibercept
Caregen Co. Ltd.
Phase 1
45
Connecticut, Florida, Georgia, Indiana, North Dakota, Pennsylvania
2023-12-22
Active, closed
Trial of Efficacy and Safety of NS-229 Versus Placebo in Patients With Eosinophilic Granulomatosis With Polyangiitis
NCT06046222Eosinophilic Granulomatosis With Polyangiitis, Churg-Strauss Syndrome
NS Pharma, Inc.
Phase 2
45
Colorado, Minnesota, Ohio, Pennsylvania, South Carolina, Tennessee
2023-12-20
Recruiting
Phase 1 Trial of ST-001 nanoFenretinide in Relapsed/Refractory T-cell Non-Hodgkin Lymphoma
NCT04234048T-cell Lymphoma, Cutaneous/Peripheral T-Cell Lymphoma, Peripheral T-cell Lymphoma, Peripheral T-Cell Lymphoma, Not Classified
DrugFenretinide
SciTech Development, Inc.
Phase 1
46
Arizona, California, Colorado, Illinois, Michigan, New York, Pennsylvania, Texas
2023-12-18
Active, closed
A Study of Acalabrutinib Plus Venetoclax and Rituximab in Participants With Treatment Naïve Mantle Cell Lymphoma
NCT05951959Mantle Cell Lymphoma (MCL)
DrugsAcalabrutinib·Venetoclax·Rituximab
AstraZeneca
Phase 2
108
New Jersey, New York, Ohio, Pennsylvania, Texas
2023-12-13
Active, closed
Study of Lenacapavir and Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF) for Prevention of HIV in People Who Inject Drugs (HPTN 103)
NCT06101342Pre-Exposure Prophylaxis of HIV Infection
DrugsEmtricitabine/tenofovir disoproxil fumarate·F/TDF·Lenacapavir
Gilead Sciences
Phase 2
181
California, Florida, Maryland, New Jersey, New York, Pennsylvania, Texas, West Virginia
2023-12-13
Recruiting
AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma
NCT06106945Multiple Myeloma
DrugsElranatamab·Pomalidomide·Dexamethasone
AstraZeneca
Phase 1/2
226
California, Georgia, Massachusetts, Michigan, Missouri, New York, Pennsylvania, Virginia
2023-12-05
Recruiting
Safety and Effectiveness Evaluation of the COLO-BT as an Alternative Treatment to the Ileostomy
NCT05826743Colorectal Surgery, Colorectal Cancer, Rectal/Anal, Ileostomy - Stoma
JSR Medical Co., Ltd.
Not applicable
256
New York, Pennsylvania, Texas
2023-12-04
Recruiting
Personalized Postoperative Pain Management Following Thoracic Surgery in Adults
NCT05525923Thoracic Surgery, Pneumonectomy, Lobectomy, Segmentectomy
OpalGenix, Inc
Observational
200
Pennsylvania
2023-11-30
Active, closed
An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery
NCT06117891Unresectable Hepatocellular Carcinoma
DrugsTremelimumab·Atezolizumab·Durvalumab·Bevacizumab
Bayer
Observational
300
Maryland, Michigan, New York, Ohio, Pennsylvania
2023-11-27
Active, closed
A Study of JNJ-86974680 in Participants With Advanced Non-small Cell Lung Cancer
NCT06116786Carcinoma, Non-small-Cell Lung
DrugsJNJ-86974680·Cetrelimab
Johnson & Johnson Enterprise Innovation Inc.
Phase 1
67
Georgia, New Jersey, New York, Oregon, Pennsylvania, Virginia
2023-11-27
Active, closed
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
NCT06031441Locally Advanced Solid Tumors, Recurrent Solid Tumors, Metastatic Solid Tumors
DrugsTecentriq·Atezolizumab
Genentech, Inc.
Phase 1
65
Alabama, Connecticut, New York, Ohio, Pennsylvania, Tennessee
2023-11-27
Active, closed
A Study for GSK3862995B in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
NCT06154837Pulmonary Disease, Chronic Obstructive
DrugGSK3862995B
GlaxoSmithKline
Phase 1
127
Arizona, Florida, Georgia, North Carolina, Oregon, Pennsylvania, South Carolina, Texas
2023-11-27
Recruiting
A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)
NCT06173518Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia, Relapsed or Refractory B Cell Non-Hodgkin Lymphoma
DrugAUTO1
Autolus Limited
Phase 1
30
Colorado, Illinois, Ohio, Pennsylvania, Texas, Utah
2023-11-16
Active, closed
A Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Sclerosis Patients
NCT06292923Secondary Progressive Multiple Sclerosis
Tiziana Life Sciences LTD
Phase 2
54
Connecticut, Maryland, Massachusetts, New York, Pennsylvania
2023-11-15
Active, closed
A Post-Market Study for Long-Term Effectiveness and Safety of the TOMAC System for RLS
NCT06076499Restless Legs Syndrome
Noctrix Health, Inc.
Observational
325
California, Massachusetts, Missouri, Ohio, Pennsylvania, South Carolina
2023-11-15
Recruiting
Safety Study for a Gamma Delta T Cell Product Used With Low Dose Radiotherapy in Patients With Locally Advanced or Metastatic NSCLC or Solid Tumors With Bone Metastases
NCT06069570Carcinoma, Non-Small-Cell Lung Cancer, Bone Metastases From Solid Tumors
Kiromic BioPharma Inc.
Phase 1
48
Arizona, California, Pennsylvania, Texas, Virginia
2023-11-07
Recruiting
JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors
NCT06108050Advanced Solid Tumor, Metastatic Solid Tumor
DrugPembrolizumab
Jazz Pharmaceuticals
Phase 1
177
California, Colorado, Florida, North Carolina, Pennsylvania, Tennessee, Texas, Virginia
2023-11-07
Active, closed
A Study of JNJ-90009530 in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (r/r B-NHL)
NCT05784441Relapsed or Refractory B Cell Non-Hodgkin Lymphoma
Janssen Research & Development, LLC
Phase 1
21
Iowa, Kentucky, Minnesota, New Jersey, Ohio, Pennsylvania, Texas
2023-11-06
Recruiting
Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an IPAA (PROF)
NCT05938465Ileal Pouch
Exegi Pharma, LLC
Phase 1/2
50
California, Florida, Michigan, Minnesota, Missouri, New York, North Carolina, Pennsylvania
2023-11-06
Recruiting
A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer
NCT06095089Prostatic Neoplasms
DrugsJNJ-101556143·JNJ-87189401·Lutetium Lu-177 vipivotide tetraxetan·Pasritamig
Janssen Research & Development, LLC
Phase 1
355
Colorado, Georgia, Minnesota, New Jersey, New York, North Carolina, Oregon, Pennsylvania
2023-11-01
Active, closed
Open-Label Study to Evaluate the Safety and Effectiveness of the Spirair Implant
NCT06163404Nasal Septal Deviation, Nasal Airway Obstruction
Spirair, Inc
Not applicable
102
Alabama, California, Kentucky, Louisiana, New York, Pennsylvania, Washington
2023-11-01
Recruiting
A Phase 1/2, First-in-Human Study On ODM-212 In Subjects With Selected Advanced Solid Tumours
NCT06725758Solid Tumours
DrugODM-212
Orion Corporation, Orion Pharma
Phase 1/2
315
California, Missouri, New York, Pennsylvania, Texas, Virginia
2023-10-26
Recruiting
Safety and Efficacy of OBX-115 in Advanced Solid Tumors
NCT06060613Tumor Skin, Metastatic Melanoma, Melanoma, Lung Cancer
Obsidian Therapeutics, Inc.
Phase 1/2
254
California, Florida, Kentucky, New York, Ohio, Pennsylvania, Texas
2023-10-25
Active, closed
Nerve Protection Evaluation: Revision Cubital Tunnel Syndrome Decompression
NCT06117501Recurrent Cubital Tunnel Syndrome, Recalcitrant Cubital Tunnel Syndrome
Axogen Corporation
Not applicable
20
Florida, Georgia, Indiana, New Mexico, Ohio, Pennsylvania, Utah
2023-10-19
Recruiting
R-2487 in Patients With Rheumatoid Arthritis
NCT05961592Arthritis, Rheumatoid
Rise Therapeutics LLC
Phase 1
73
California, Florida, Pennsylvania, Texas
2023-10-19
Recruiting
An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant
NCT05106387Chronic Kidney Disease (CKD)
DrugVonsetamig
Regeneron Pharmaceuticals
Observational
20
California, Connecticut, Illinois, Maryland, Minnesota, New York, Pennsylvania
2023-10-19
Active, closed
Diagnostic Performance of Small RNA Blood Test in Patients Undergoing Follow-up Imaging After Positive Low Dose CT Screening for Cancer of the Lung
NCT05987189Lung Cancer
Hummingbird Diagnostics
Observational
2,000
Georgia, Louisiana, Massachusetts, Michigan, New York, Pennsylvania, Texas, Utah
2023-10-18
Recruiting
A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.
NCT06022029Triple Negative Breast Cancer, Diffuse Large B Cell Lymphoma, Follicular Lymphoma, Lymphoma, Non-Hodgkin
DrugCemiplimab
OncoNano Medicine, Inc.
Phase 1
168
California, Florida, Ohio, Pennsylvania, Texas, Virginia
2023-10-13
By invitation
A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
NCT06044337Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
DrugLitifilimab
Biogen
Phase 3
306
Alabama, Arizona, California, Michigan, Missouri, North Carolina, Ohio, Pennsylvania
2023-10-03
Recruiting
Study to Evaluate Safety and Efficacy of Different PANZYGA Dose Regimens in Pediatric Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) Patients
NCT04929236Pediatric Chronic Inflammatory Demyelinating Polyneuropathy
DrugPanzyga
Octapharma
Phase 3
30
Alabama, California, Kentucky, Pennsylvania, Texas, Virginia
2023-10-01
Active, closed
Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG
NCT05610891High-Grade Glioma
DrugCLR 131
Cellectar Biosciences, Inc.
Phase 1
50
California, New York, Ohio, Pennsylvania, Texas, Wisconsin
2023-10-01
Recruiting
First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations
NCT06043817Non-Small Cell Lung Cancer, NSCLC, EGFR/HER2 Exon 20 Insertion Mutation
Pierre Fabre Medicament
Phase 1/2
345
California, North Carolina, Pennsylvania, Tennessee, Texas, Utah, Virginia
2023-09-26
Active, closed
Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2
NCT05911295Urothelial Carcinoma
DrugsDisitamab Vedotin·Keytruda·Gemcitabine·Cisplatin
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
412
Arizona, California, Minnesota, Pennsylvania, Texas, Washington
2023-09-22
Recruiting
Long-Term SafEty and Clinical Outcomes of LivmArli in Patients in the United States (LEAP-US)
NCT06193928Alagille Syndrome, Progressive Familial Intrahepatic Cholestasis
DrugsLivmarli·Maralixibat
Mirum Pharmaceuticals, Inc.
Observational
70
California, Colorado, Georgia, Missouri, Oregon, Pennsylvania, Utah
2023-09-21
Active, closed
A Study of AT-02 in Subjects With Systemic Amyloidosis.
NCT05951049Amyloidosis; Systemic
Attralus, Inc.
Phase 2
120
Kansas, Ohio, Oregon, Pennsylvania
2023-09-21
By invitation
An Extension Study of the Long-Term Safety, Tolerability, and Efficacy of Tividenofusp Alfa (DNL310) in Participants With Mucopolysaccharidosis Type II (MPS II) From Study DNLI-E-0002 or Study DNLI-E-0007
NCT06075537Mucopolysaccharidosis II
DrugTividenofusp alfa
Denali Therapeutics Inc.
Phase 2/3
99
California, Illinois, New Jersey, North Carolina, Ohio, Pennsylvania, Texas, Utah
2023-09-20
Recruiting
Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss
NCT05821959Sensorineural Hearing Loss, Bilateral
Eli Lilly and Company
Phase 3
48
California, Iowa, Massachusetts, Ohio, Pennsylvania, Tennessee
2023-09-15
Active, closed
Clinical Trial of the Cryosa System for the Treatment of Obstructive Sleep Apnea
NCT06008626Obstructive Sleep Apnea of Adult
Cryosa, Inc.
Not applicable
25
Colorado, Florida, Illinois, Louisiana, New York, Pennsylvania, Tennessee, Texas
2023-09-12
Recruiting
Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer
NCT05877430NSCLC, HNSCC, Melanoma, Metastatic Cancer
DrugPembrolizumab
CJ Bioscience, Inc.
Phase 1/2
160
California, Pennsylvania
2023-09-11
Active, closed
Cryoablation for Monomorphic Ventricular Tachycardia
NCT05675865Sustained VT
Adagio Medical
Not applicable
206
Arizona, California, Maryland, Massachusetts, Michigan, New York, Ohio, Pennsylvania
2023-09-11
Recruiting
Study to Evaluate IMGS-001 Treatment in Patients With Relapsed or Refractory Advanced Solid Tumors
NCT06014502Solid Tumor
ImmunoGenesis
Phase 1
105
Arizona, California, Florida, Kentucky, Louisiana, Missouri, Pennsylvania, Texas
2023-09-07
Recruiting
A Gene Therapy Study of RP-A501 in Male Patients With Danon Disease
NCT06092034Danon Disease
Rocket Pharmaceuticals Inc.
Phase 2
14
California, Massachusetts, Pennsylvania
2023-09-05
Recruiting
SPEARHEAD-3 Pediatric Study
NCT05642455Synovial Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST), Neuroblastoma (NBL), Osteosarcoma
USWM CT, LLC
Phase 1/2
20
California, Maryland, Massachusetts, Missouri, New York, North Carolina, Ohio, Pennsylvania
2023-09-01
By invitation
HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP
NCT05883748Erythropoietic Protoporphyria
DrugBitopertin
Disc Medicine, Inc
Phase 2/3
230
Alabama, California, Florida, Massachusetts, New York, North Carolina, Ohio, Pennsylvania
2023-08-31
Recruiting
Study of AVZO-021 in Patients With Advanced Solid Tumors
NCT05867251Advanced Solid Tumor, HR+/HER2- Breast Cancer, HR+, HER2-, Advanced Breast Cancer, CCNE1 Amplification
DrugsAVZO-021·Sacituzumab Govitecan·Abemaciclib·Ribociclib
Avenzo Therapeutics, Inc.
Phase 1/2
430
Connecticut, Florida, New York, Ohio, Oklahoma, Oregon, Pennsylvania, Texas
2023-08-30
Recruiting
A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)
NCT05885412PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)
Rocket Pharmaceuticals Inc.
Phase 1
9
California, North Carolina, Pennsylvania
2023-08-29
Recruiting
Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma
NCT05874414Cholangiocarcinoma
DrugTrametinib
Genfit
Phase 1/2
98
California, Florida, Illinois, New York, Pennsylvania, Texas, Virginia, Wisconsin
2023-08-21
Recruiting
IBS Skin Patch Test Food Allergy Study
NCT06288672Irritable Bowel Syndrome
IBS-80, LLC
Not applicable
250
Pennsylvania, West Virginia
2023-08-15
Recruiting
Regeneration of Acutely Injured Nerves With Temporary Electrical Stimulation
NCT05721261Nerve Injury
Epineuron Technologies Inc.
Not applicable
110
Florida, Louisiana, Maryland, Pennsylvania, Texas
2023-08-11
Recruiting
Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM
NCT05836259Hypertrophic Cardiomyopathy
Tenaya Therapeutics
Phase 1/2
30
California, Georgia, Massachusetts, Minnesota, Ohio, Oregon, Pennsylvania, Texas
2023-08-10
Active, closed
4D-150 in Patients With Diabetic Macular Edema
NCT05930561Diabetic Macular Edema, Diabetic Retinopathy
DrugsAflibercept IVT·4D-150 IVT·Eylea
4D Molecular Therapeutics
Phase 2
72
Maryland, Oregon, Pennsylvania, Texas, Virginia
2023-08-09
Active, closed
A Phase 1/Phase 2 Open-label Study to Evaluate the Safety, Tolerability, and Efficacy of a Single Intravenous Administration of SAR444836 in Adult Participants With Phenylketonuria
NCT05972629Phenylketonuria
Sanofi
Phase 1/2
32
California, Colorado, Florida, Ohio, Pennsylvania, South Carolina, Texas
2023-08-07
Recruiting
A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.
NCT05867420Advanced Solid Tumors
DrugsFruquintinib·Docetaxel·Paclitaxel·Bevacizumab
AskGene Pharma, Inc.
Phase 1/2
594
New York, Pennsylvania
2023-08-02
Active, closed
Cemented vs Cementless Persona Keel RCT
NCT05630053Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis
Zimmer Biomet
Not applicable
300
Colorado, Illinois, Maryland, Oregon, Pennsylvania, Virginia
2023-07-25
Recruiting
A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
NCT05836324Solid Tumors, Advanced Solid Tumors, Metastatic Solid Tumors
DrugsINCA33890·ADG126·Folfiri·Folfox
Incyte Corporation
Phase 1
570
California, Massachusetts, Michigan, New Jersey, New York, Pennsylvania, Rhode Island, Texas
2023-07-24
Recruiting
A Study to Evaluate the Safety, Efficacy, PK, PD and Immunogenicity of Cipaglucosidase Alfa/Miglustat in IOPD Subjects Aged 0 to <18
NCT04808505Glycogen Storage Disease Type II Infantile Onset
DrugsCipaglucosidase alfa·Miglustat
Amicus Therapeutics
Phase 3
36
Florida, Georgia, North Carolina, Ohio, Pennsylvania, Utah
2023-07-18
Active, closed
Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors
NCT05945823Locally Advanced Unresectable or Metastatic Solid Tumors Including Esophageal Cancer, Esophageal Adenocarcinoma, Esophageal Squamous Cell Cancer, Siewert Type 1 GEJ Cancer
DrugsFutibatinib·Leucovorin·Irinotecan·Adrucil
Taiho Oncology, Inc.
Phase 2
53
California, Colorado, Florida, Michigan, New Jersey, New York, Ohio, Pennsylvania
2023-07-13
Active, closed
24 Weeks Double-blind Randomized Placebo-controlled Trial to Evaluate Efficacy, PK, Safety of LOU064 in Adolescents (12 - <18) With CSU and Inadequate Response to H1-antihistamine Followed by Optional 3 Years Open-label Extension and an Optional 3 Years Safety Long-term Treatment-free Follow-up
NCT05677451Chronic Spontaneous Urticaria
DrugRemibrutinib
Novartis Pharmaceuticals
Phase 3
100
California, Florida, Idaho, Illinois, Kentucky, Ohio, Oklahoma, Pennsylvania
2023-07-11
Recruiting
Pediatric Percutaneous Ultrasound Gastrostomy Technique
NCT05966311Gastrostomy, Gastrostomy Complications, Pediatric Disorder, Ultrasound
CoapTech
Not applicable
80
District of Columbia, New York, Pennsylvania
2023-07-07
Active, closed
(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma
NCT05907954Uveal Melanoma
DrugDarovasertib
IDEAYA Biosciences
Phase 2
160
Arizona, California, Florida, Michigan, Minnesota, New York, Pennsylvania, Tennessee
2023-07-03
Recruiting
Study of ART6043 in Advanced/Metastatic Solid Tumors Patients (POLKA)
NCT05898399Advanced Solid Tumor, Metastatic Solid Tumor
DrugOlaparib
Artios Pharma Ltd
Phase 1/2
181
Michigan, New York, Oklahoma, Pennsylvania, Tennessee, Texas
2023-06-30
Active, closed
The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency or ABCC6 Deficiency
NCT05734196Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency, Autosomal Recessive Hypophosphatemic Rickets, Generalized Arterial Calcification of Infancy, ATP-Binding Cassette Subfamily C Member 6 Deficiency
DrugINZ-701
Inozyme Pharma
Phase 1
16
California, Ohio, Pennsylvania
2023-06-25
Active, closed
Evaluation of PK, PD, Efficacy, Safety, and Immunogenicity of IV Ravulizumab in Pediatric Participants With Generalized Myasthenia Gravis
NCT05644561Generalized Myasthenia Gravis, gMG
DrugRavulizumab
Alexion Pharmaceuticals, Inc.
Phase 3
12
California, Massachusetts, North Carolina, Pennsylvania
2023-06-24
Recruiting
A Retrospective Study to Characterize Participants With Propionic Acidemia
NCT05769621Propionic Acidemia
ModernaTX, Inc.
Observational
60
California, Maryland, Michigan, Pennsylvania, Texas, Washington
2023-06-16
Recruiting
Safety and Tolerability Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD) and Non-interventional Arm With Untreated Patients
NCT05616793LCA5
Opus Genetics, Inc
Phase 1/2
22
Pennsylvania, Texas
2023-06-15
Active, closed
Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
NCT05835895Osteoarthritis, Knee, Osteo Arthritis Knee, Knee Osteoarthritis
Genascence Corporation
Phase 1
67
Alabama, California, Florida, Missouri, North Carolina, Pennsylvania
2023-06-12
Active, closed
Study of LP-184 in Patients With Advanced Solid Tumors
NCT05933265Advanced Solid Tumor, Metastatic Solid Tumor, GBM, TNBC - Triple-Negative Breast Cancer
DrugsOlaparib·Ipilimumab
Lantern Pharma Inc.
Phase 1/2
64
Arkansas, Indiana, Kentucky, Maryland, Pennsylvania, Texas, Utah
2023-06-09
Recruiting
A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors
NCT05948865Cancer, Cancer, Lung
DrugSYS6010
Conjupro Biotherapeutics, Inc.
Phase 1
132
California, Colorado, Florida, New Hampshire, Pennsylvania, Tennessee, Texas, Virginia
2023-06-06
Recruiting
MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
NCT05655312Recurrent Melanoma (Skin), Metastatic Melanoma, Melanoma Stage IV, Melanoma Stage III
DrugNivolumab
Perspective Therapeutics
Phase 1/2
300
California, Florida, Iowa, Kentucky, Minnesota, Missouri, Nebraska, Pennsylvania
2023-06-01
Active, closed
A Study Evaluating the Safety and Efficacy of BEAM-201 in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LL)
NCT05885464Lymphoblastic Lymphoma, T-Cell Lymphoblastic Leukemia/Lymphoma, Lymphoblastic Leukemia
Beam Therapeutics Inc.
Phase 1/2
5
California, Colorado, Illinois, Kansas, Massachusetts, Ohio, Oregon, Pennsylvania
2023-05-25
Recruiting
A Phase I Study of ROSE12 Alone and in Combination With Other Anti-tumor Agents in Patients With Solid Tumors
NCT05907980Solid Tumor
DrugsAtezolizumab·Pembrolizumab
Chugai Pharmaceutical
Phase 1
209
Pennsylvania, Rhode Island, Tennessee, Texas, Virginia
2023-05-24
Active, closed
An Observational Registry Assessing the Impact of PYLARIFY® (Piflufolastat F18) PET in Patients With Prostate Cancer
NCT05712473Prostate Cancer
Lantheus Medical Imaging
Observational
500
Alabama, Arkansas, California, Michigan, Missouri, Nebraska, Pennsylvania, Tennessee
2023-05-22
Active, closed
Long-term Follow-up of Glutamic Acid Decarboxylase (GAD) Gene Transfer in Parkinson's Disease
NCT05894343Parkinson's Disease
MeiraGTx, LLC
Phase 1/2
13
Connecticut, Michigan, New York, Pennsylvania, West Virginia
2023-05-19
Recruiting
MASA Valve Early Feasibility Study
NCT05452720Tetrology of Fallot, Pulmonary Stenosis, Truncus Arteriosus, Transposition of Great Vessels
PECA Labs
Not applicable
10
Illinois, Massachusetts, Ohio, Pennsylvania, Texas
2023-05-18
Recruiting
A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
NCT05319730Esophageal Squamous Cell Carcinoma
DrugsMK-4830·Steroid mouthwash (dexamethasone·Acetaminophen·Sacituzumab tirumotecan
Merck Sharp & Dohme LLC
Phase 1/2
230
Arizona, California, New York, Pennsylvania
2023-05-16
Active, closed
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
NCT05791201Type 1 Diabetes
Vertex Pharmaceuticals Incorporated
Phase 1/2
7
Florida, Illinois, Massachusetts, Pennsylvania, Wisconsin
2023-05-16
Recruiting
XTX301 in Patients With Advanced Solid Tumors
NCT05684965Advanced Solid Tumor
Xilio Development, Inc.
Phase 1/2
358
California, Connecticut, Minnesota, Missouri, New Jersey, Ohio, Pennsylvania, Texas
2023-05-11
Active, closed
A Study of HFB200603 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
NCT05789069Renal Cell Carcinoma, Melanoma, Non Small Cell Lung Cancer, Gastric Cancer
DrugTislelizumab
HiFiBiO Therapeutics
Phase 1
83
California, Pennsylvania, Virginia
2023-05-09
Active, closed
Portable Neuromodulation Stimulator Registry for People With Multiple Sclerosis
NCT06930339Multiple Sclerosis
Helius Medical Inc
Observational
150
Pennsylvania
2023-05-01
Recruiting
Comparison of Transforming Powder Dressing to NPIAP Recommended Standard of Care Therapies in Stage 2, 3 and 4 Pressure Injuries
NCT05496296Pressure Ulcers Stage II, Pressure Ulcers Stage III, Pressure Ulcer, Stage IV
ULURU Inc.
Not applicable
300
California, District of Columbia, Illinois, Maryland, New Jersey, New York, Pennsylvania, Texas
2023-04-30
Recruiting
A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer
NCT05818683Metastatic Castration-resistant Prostate Neoplasms, Metastatic Hormone-sensitive Prostate Cancer
DrugsJNJ-101556143·Lutetium Lu-177 vipivotide tetraxetan·Pasritamig·Cabazitaxel
Janssen Research & Development, LLC
Phase 1
300
Florida, Michigan, Missouri, New York, Pennsylvania
2023-04-26
Recruiting
Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)
NCT05765175Tachycardia, Ventricular
Varian, a Siemens Healthineers Company
Not applicable
380
California, Connecticut, Massachusetts, Minnesota, Missouri, Ohio, Pennsylvania, South Carolina
2023-04-21
Recruiting
A Study to Investigate the Safety, Tolerability, and Efficacy of BxC-I17e Single and Multiple Dose SC Injection in Patients With Moderate to Severe Atopic Dermatitis
NCT06055361Atopic Dermatitis
Brexogen Inc.
Phase 1
45
Arkansas, Pennsylvania
2023-04-18
Recruiting
Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer
NCT05804318Prostate Cancer
Varian, a Siemens Healthineers Company
Not applicable
132
California, Massachusetts, Missouri, Pennsylvania
2023-04-13
Active, closed
Promising ROd-cone DYstrophy Gene therapY
NCT05748873Retinitis Pigmentosa
SparingVision
Phase 1/2
33
Florida, Massachusetts, Oregon, Pennsylvania, Texas
2023-04-12
Active, closed
A Study of Dostarlimab in Untreated dMMR/MSI-H Locally Advanced Rectal Cancer
NCT05723562Neoplasms, Rectal
DrugDostarlimab
GlaxoSmithKline
Phase 2
154
California, New Mexico, New York, Pennsylvania, Tennessee, Texas, Virginia
2023-04-03
Active, closed
In-Office Clinical Study of the Solo+ TTD
NCT05741333Ear Infection, Otitis Media
AventaMed DAC
Not applicable
66
Alabama, California, Kentucky, Pennsylvania, South Carolina
2023-03-30
Active, closed
PerQseal® Clinical Study
NCT05653336Percutaneous Large Hole Vascular Closure
Vivasure Medical Limited
Not applicable
149
Arizona, California, Maine, New Jersey, New York, Ohio, Pennsylvania, Texas
2023-03-30
Recruiting
SynKIR-110 for Mesothelin Expressing Ovarian Cancer, Cholangiocarcinoma or Mesothelioma
NCT05568680Ovarian Cancer, Cholangiocarcinoma Recurrent, Mesothelioma, Malignant
Verismo Therapeutics
Phase 1
42
Florida, Kansas, Pennsylvania, Texas, Wisconsin
2023-03-30
Recruiting
A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251
NCT05626114Geographic Atrophy
DrugOpRegen
Genentech, Inc.
Phase 2
60
California, Florida, Maryland, Missouri, Nevada, North Carolina, Ohio, Pennsylvania
2023-03-23
Active, closed
Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer
NCT05669482KRAS Activating Mutation, Metastatic Cancer, Pancreas Cancer, Neoplasms Pancreatic
DrugsAvutometinib (VS-6766) and defactinib·Gemcitabine and nab-paclitaxel
Verastem, Inc.
Phase 1/2
40
California, Illinois, Massachusetts, Michigan, Missouri, New York, Pennsylvania, Utah
2023-03-22
Recruiting
Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
NCT05776069Von Willebrand Diseases
DrugVGA039
Vega Therapeutics, Inc
Phase 1/2
116
California, Colorado, Georgia, North Carolina, Pennsylvania, Tennessee, Texas, Washington
2023-03-16
Recruiting
Vivistim Registry for Paired VNS Therapy (GRASP)
NCT05301140Upper Extremity Problem
MicroTransponder Inc.
Observational
1,000
Florida, Illinois, Kansas, Kentucky, New Jersey, New York, Pennsylvania, Texas
2023-03-15
Active, closed
A Study of HST-1011 Given as Monotherapy and in Combination With an Anti-PD1 Antibody
NCT05662397Solid Tumor, Adult, Relapsed Cancer, Refractory Cancer
DrugCemiplimab
HotSpot Therapeutics, Inc
Phase 1/2
77
Florida, Nevada, New York, Oregon, Pennsylvania, Texas
2023-03-15
Recruiting
Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or Targeted Therapy and/or ICI, for the Treatment of Patients With Advanced Gastrointestinal Cancers, Including Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)
NCT05482893Gastric or Gastroesophageal Junction Adenocarcinoma, Pancreatic Ductal Adenocarcinoma, Biliary Tract Cancer (BTC), Colorectal Cancer
DrugsNalirifox·Folfirinox·Trifluridine/Tipiracil·Abraxane
Phanes Therapeutics
Phase 1/2
350
California, Colorado, Iowa, Kentucky, Massachusetts, North Carolina, Pennsylvania, Texas
2023-03-15
Recruiting
An Open-Label Exploratory Study of Fosigotifator in Participants With Vanishing White Matter Disease
NCT05757141Vanishing White Matter Disease
DrugFosigotifator
Calico Life Sciences LLC
Phase 1/2
50
Massachusetts, Pennsylvania, Utah
2023-03-13
Recruiting
A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma
NCT05456256Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung
DrugsParaplatin·Pemetrexed·Carboplatin
Lantern Pharma Inc.
Phase 2
90
California, Pennsylvania, Texas, Virginia
2023-03-01
Active, closed
Study of DECOY20 With or Without Tislelizumab in Patients With Advanced Solid Tumors
NCT05651022Solid Tumor, Adult, HCC - Hepatocellular Carcinoma, CRC (Colorectal Cancer), Pancreatic Adenocarcinoma
DrugTislelizumab
Indaptus Therapeutics, Inc
Phase 1/2
120
California, Georgia, Michigan, Missouri, New Jersey, New York, Ohio, Pennsylvania
2023-02-28
Active, closed
Study to Assess the Safety and Efficacy of OCU410 for Geographic Atrophy
NCT06018558Geographic Atrophy
Ocugen
Phase 1/2
60
Arizona, Florida, Indiana, Mississippi, Missouri, New Jersey, North Carolina, Pennsylvania
2023-02-23
By invitation
An Extension Study of JR-141 to Evaluate the Long-term Safety and Efficacy in MPS II (Hunter Syndrome) Subjects
NCT05594992Mucopolysaccharidosis II
DrugJR-141
JCR Pharmaceuticals Co., Ltd.
Phase 3
80
California, Pennsylvania
2023-02-22
Active, closed
A Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Antiretroviral Therapy (ART) (MK-8591A-051)
NCT05631093HIV-1 Infection
DrugsDOR/ISL·B/F/TAF
Merck Sharp & Dohme LLC
Phase 3
553
California, District of Columbia, Florida, Georgia, New Jersey, Pennsylvania, Texas
2023-02-20
Recruiting
A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer
NCT05683418HR+/HER2-negative Breast Cancer
DrugsRibociclib·Palbociclib·Fulvestrant
Totus Medicines
Phase 1
241
Illinois, Massachusetts, Nevada, Pennsylvania, Tennessee, Texas, Virginia
2023-02-15
Recruiting
Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies
NCT05682378Heterozygous or Homozygous Familial Hypercholesterolemia
DrugInclisiran
Novartis Pharmaceuticals
Phase 3
195
Florida, New York, Ohio, Pennsylvania, Utah
2023-02-10
Active, closed
Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study
NCT05797896Dry Age-related Macular Degeneration, Geographic Atrophy, Retinal Disease, Macular Degeneration
Complement Therapeutics
Observational
250
California, Indiana, Maryland, Nevada, Oregon, Pennsylvania, Texas
2023-02-07
Active, closed
Pilot/Pivotal Study of DBS+Rehab After Stroke
NCT05701280Stroke, Upper Extremity Paresis
Enspire DBS Therapy, Inc.
Not applicable
202
Arizona, Maryland, Massachusetts, Minnesota, New York, Ohio, Pennsylvania, Rhode Island
2023-02-03
Active, closed
A Study to Test a Medicine (Fitusiran) Injected Under the Skin for Preventing Bleeding Episodes in Male Adolescent or Adult Participants With Severe Hemophilia
NCT05662319Hemophilia
DrugsAntithrombin·Clotting factor concentrates·Fitusiran
Sanofi
Phase 3
91
California, Minnesota, New Jersey, New York, Ohio, Pennsylvania, Texas
2023-02-01
Active, closed
Stryker PEEK Customized Implant: A Prospective Post Market Follow Up to Evaluate Safety, Performance and Effectiveness
NCT05362370Cranioplasty, Craniofacial Abnormalities, Craniofacial Injuries
Stryker Craniomaxillofacial
Observational
99
Kentucky, New Jersey, New York, Pennsylvania, South Carolina
2023-02-01
Recruiting
The Impact of MeMed BV® on Management of Patients With Suspected Lower Respiratory Tract Infections (LRTI) in the Emergency Department (ED) and Urgent Care Center (UCC) ("JUPITER" TRIAL)
NCT05762302Lower Respiratory Tract Infection
MeMed Diagnostics Ltd.
Not applicable
1,316
Florida, Kansas, New York, Pennsylvania, South Carolina, Texas, Wisconsin
2023-01-31
Recruiting
A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications
NCT05539196Movement Disorders, Neurology, Parkinsons Disease
InSightec
Observational
60
Maryland, New York, Pennsylvania, Texas
2023-01-23
Recruiting
Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)
NCT05587712Pulmonary Arterial Hypertension
DrugSotatercept
Merck Sharp & Dohme LLC
Phase 2
42
California, Colorado, District of Columbia, Ohio, Pennsylvania, Tennessee, Washington, Wisconsin
2023-01-19
Active, closed
A Clinical Trial to Investigate the Long-term Safety and Tolerability, Efficacy, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of ARGX-117 in Adults With Multifocal Motor Neuropathy
NCT05405361Multifocal Motor Neuropathy (MMN)
DrugEmpasiprubart
argenx
Phase 2
51
Arizona, Illinois, Minnesota, Ohio, Pennsylvania, Texas
2023-01-18
Recruiting
Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
NCT05702229Gastric Cancer
DrugsSonesitatug Vedotin·Volrustomig·Xelox·Rilvegostomig
AstraZeneca
Phase 2
163
California, Louisiana, Michigan, New York, Pennsylvania
2023-01-16
Active, closed
A Study to Investigate the Efficacy and Safety of Dupilumab Therapy Compared With Placebo in Participants Aged ≥18 Years With Moderately to Severely Active Ulcerative Colitis With an Eosinophilic Phenotype (LIBERTY-UC SUCCEED (Study in UC for Clinical Efficacy Evaluation of Dupilumab))
NCT05731128Colitis Ulcerative
DrugDupilumab
Sanofi
Phase 2
68
California, Florida, Georgia, New Jersey, New York, North Carolina, Pennsylvania, Texas
2023-01-12
By invitation
A Long-Term Follow-Up Study in Severe Hemophilia A Subjects Who Received BMN 270 in a Prior BioMarin Clinical Trial (270-401)
NCT05768386Hemophilia A
BioMarin Pharmaceutical
Observational
172
California, Colorado, Florida, Kentucky, Michigan, Missouri, Ohio, Pennsylvania
2023-01-01
Recruiting
Safety and Effectiveness of Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Patients With Hemophilia A or B Respectively
NCT05568719Hemophilia A, Hemophilia B
Pfizer
Phase 3
173
California, Florida, Indiana, Mississippi, New York, Pennsylvania, Washington
2022-12-28
By invitation
Safety Extension Study for Subjects With HR+, HER2- Breast Cancer for Subjects Who Have Completed the OVELIA Study
NCT05645536Breast Cancer
DrugsTOL2506·Tamoxifen·Exemestane·Anastrozole
Tolmar Inc.
Phase 3
250
California, Florida, Kentucky, Maryland, New York, North Carolina, Pennsylvania, Tennessee
2022-12-28
Active, closed
Safety and Effectiveness of the Genio® bilAteral Stimulation for Treatment of Complete Concentric CollapsE and OSA.
NCT05592002Sleep Apnea, Obstructive
Nyxoah S.A.
Not applicable
124
Colorado, Florida, Indiana, Iowa, Kansas, Massachusetts, New York, Pennsylvania
2022-12-28
Recruiting
Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
NCT05283330Cervical Cancer, Breast Cancer, Colon Cancer, NSCLC
Orano Med Theranostics, SAS
Phase 1
48
Illinois, Iowa, Kentucky, Maryland, Nebraska, Pennsylvania
2022-12-22
Active, closed
First in Human Study of AZD9592 in Solid Tumors
NCT05647122Advanced Solid Tumours, Carcinoma Non-small Cell Lung, Head and Neck Neoplasms, Colorectal Neoplasms
DrugsAZD9592·Osimertinib·Leucovorin·Adrucil
AstraZeneca
Phase 1
190
California, Connecticut, District of Columbia, Illinois, Maryland, Massachusetts, New York, Pennsylvania
2022-12-21
Active, closed
A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Participants With International Prognostic Scoring System Revised (IPSS-R) Low- or Intermediate-risk Myelodysplastic Syndrome (MDS)
NCT05469737Myelodysplastic Syndromes
DrugAzacitidine
Bristol-Myers Squibb
Phase 2/3
230
Florida, New York, Pennsylvania, Texas, Virginia
2022-12-14
Active, closed
A Phase 1/2 Study to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of HMB-001 in Glanzmann Thrombasthenia
NCT06211634Glanzmann Thrombasthenia
Hemab ApS
Phase 1/2
57
California, Louisiana, Minnesota, Pennsylvania, Washington
2022-12-13
Active, closed
A Study to Assess the Safety and Efficacy of Vatiquinone in Participants With Friedreich Ataxia
NCT05515536Friedreich Ataxia
DrugVatiquinone
PTC Therapeutics
Phase 3
130
California, Florida, Iowa, Pennsylvania
2022-12-08
Active, closed
A Clinical Trial in Healthy Volunteers and Volunteers With Recurrent Genital Herpes to Study the Safety, Tolerability, and Immune Responses After Vaccination With an Investigational Vaccine Designed to Prevent Genital Herpes Lesions
NCT05432583Genital Herpes Simplex Type 2
BioNTech SE
Phase 1
318
Arizona, Illinois, North Carolina, Ohio, Pennsylvania
2022-12-08
By invitation
Safety, Tolerability and Efficacy of ICV AX 250 Treatment in MPS IIIB -OLE
NCT05492799MPS III B
Allievex Corporation
Phase 4
15
California, Pennsylvania
2022-12-02
Recruiting
A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis
NCT05652335Relapsed or Refractory Multiple Myeloma, Previously Treated Amyloid Light-chain (AL) Amyloidosis
DrugRamantamig
Janssen Research & Development, LLC
Phase 1
180
California, Colorado, New York, North Carolina, Pennsylvania, Texas
2022-11-22
Active, closed
A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
NCT05476926Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Branch Retinal Vein Occlusion
DrugsVabysmo·Faricimab
Hoffmann-La Roche
Observational
6,000
Arizona, California, Florida, Illinois, Kentucky, Maryland, Michigan, Pennsylvania
2022-11-21
Recruiting
A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)
NCT05562830Urothelial Carcinoma
DrugsMK-3120·Zilovertamab vedotin·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 1/2
48
California, Colorado, Illinois, Indiana, Missouri, New York, Ohio, Pennsylvania
2022-11-16
Active, closed
Safety and Effectiveness of the TENEO 317 Model 2 (1.28 US) Excimer Laser for Laser In Situ Keratomileusis (LASIK) Surgery to Treat Hyperopia With or Without Astigmatism
NCT05264623Hyperopia
Bausch & Lomb Incorporated
Not applicable
140
California, Florida, Minnesota, Nebraska, New York, Pennsylvania, South Dakota, Texas
2022-11-15
Recruiting
A Clinical Investigation to Follow the Progress of Exuding Chronic Venous Leg Ulcers Using a Non-Bordered Foam Dressing
NCT05608317Wounds, Wound of Skin, Wound Leg, Venous Leg Ulcer
Molnlycke Health Care AB
Not applicable
20
California, Florida, Pennsylvania
2022-11-08
Active, closed
A First-in-human Study to Learn How Safe the Study Drug BAY2965501 is, Find the Best Dose (Single Drug & Combination), How it Affects the Body, What Maximum Amount Can be Given, How it Moves Into, Through and Out of the Body, How it Acts on Different Tumors in Participants With Advanced Solid Tumors
NCT05614102Advanced Solid Tumors
DrugPembrolizumab
Bayer
Phase 1
284
Colorado, Pennsylvania, Texas
2022-11-04
Active, closed
A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC)
NCT05170204Non-Small Cell Lung Cancer
DrugsEntrectinib·Alectinib·Durvalumab
Hoffmann-La Roche
Phase 3
68
Oregon, Pennsylvania
2022-11-01
Recruiting
OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults
NCT05452694Lumbar Spine Stenosis, Lumbar Spine Degeneration
OpalGenix, Inc
Observational
235
Pennsylvania
2022-11-01
Recruiting
A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.
NCT05588583Wounds, Wound of Skin, Wound Leg, Wound; Foot
Molnlycke Health Care AB
Not applicable
68
California, Florida, Pennsylvania
2022-10-31
Active, closed
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
NCT05544929Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma, Carcinoma, Renal Cell, Carcinoma, Ovarian Epithelial
DrugsKeytruda·Pembrolizumab
Novartis Pharmaceuticals
Phase 1
126
Massachusetts, New York, Pennsylvania, Tennessee
2022-10-26
Active, closed
A Study About the Natural History in Adults With BAG3 Dilated Cardiomyopathy (a Type of Heart Disease) (BAG3 DCM)
NCT05981092Cardiomyopathy, Dilated, Bcl-2 Anathogene-3 (BAG3) Dilated Cardiomyopathy (DCM)
Alexion Pharmaceuticals, Inc.
Observational
35
California, Colorado, Massachusetts, Minnesota, New York, Pennsylvania
2022-10-14
Active, closed
Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic Non-Small Cell Lung Cancer
NCT05502237Non-small Cell Lung Cancer
DrugsDomvanalimab·Zimberelimab·Nab-paclitaxel·Pemetrexed
Gilead Sciences
Phase 3
1,021
California, District of Columbia, Florida, Illinois, North Carolina, Ohio, Oregon, Pennsylvania
2022-10-12
Recruiting
M-Vizion™ Macroscopic Radiographic Study
NCT05721859Revision Hip Arthroplasty
Medacta USA
Observational
70
Illinois, Massachusetts, New Hampshire, North Carolina, Pennsylvania, Utah
2022-10-12
Active, closed
A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815
NCT05557045Advanced Cancer, Metastatic Cancer, Solid Tumor, Melanoma
Jazz Pharmaceuticals
Phase 1
98
California, Colorado, Florida, Illinois, New York, Oklahoma, Pennsylvania, Tennessee
2022-10-10
Active, closed
Sterilised, Porcine Placental Tissue in the Treatment of Chronic Diabetic Foot Ulcers
NCT05687656Diabetic Foot Ulcer
ConvaTec Inc.
Not applicable
30
Florida, New York, Pennsylvania, Texas
2022-10-06
Active, closed
Study of the Adverse Events and Change in Disease State of Pediatric Participants (and Young Adults Between the Ages of 18-25) With Relapsed/Refractory Aggressive Mature B-cell Neoplasms Receiving Subcutaneous (SC) Injections of Epcoritamab
NCT05206357Non-hodgkin Lymphoma
DrugEpcoritamab
Genmab
Phase 1
17
California, Florida, New York, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
2022-10-04
Recruiting
Rocket Study: A Study to Characterize Biomarkers and Disease Progression in Participants With Pelizaeus-Merzbacher Disease
NCT05659901Pelizaeus-Merzbacher Disease
Ionis Pharmaceuticals, Inc.
Observational
32
Georgia, Maryland, Pennsylvania
2022-10-03
Recruiting
Study to Evaluate the Safety and Efficacy of Oral NRC-2694-A in Combination With Paclitaxel in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma, Who Progressed on or After Immune Checkpoint Inhibitor Therapy
NCT05283226Carcinoma, Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma
DrugPaclitaxel
NATCO Pharma Ltd.
Phase 2
21
California, Florida, Kentucky, Maryland, Missouri, New Hampshire, Pennsylvania, Wisconsin
2022-09-30
Recruiting
Outcomes Following Combined Adductoplasty™ and Lapiplasty® (MTA3D)
NCT05587569Metatarsus Adductus, Hallux Valgus
Treace Medical Concepts, Inc.
Not applicable
80
Colorado, Iowa, Maine, Missouri, North Carolina, Ohio, Pennsylvania, Texas
2022-09-28
Active, closed
A Phase 1, Open-label Trial of Belzupacap Sarotalocan (AU-011) in Bladder Cancer
NCT05483868Non-muscle-invasive Bladder Cancer, NMIBC, Non-Muscle Invasive Bladder Carcinoma, Non-Muscle Invasive Bladder Neoplasms
DrugBel-sar
Aura Biosciences
Phase 1
55
Arkansas, California, Colorado, New York, Pennsylvania, South Carolina, Tennessee, Texas
2022-09-26
Active, closed
Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma
NCT05371093Relapsed/Refractory Follicular Lymphoma
DrugsAxi-cel·Axicabtagene Ciloleucel·Bendamustine·Vincristine
Kite, A Gilead Company
Phase 3
231
California, Florida, Kansas, Maryland, Massachusetts, North Carolina, Pennsylvania, Tennessee
2022-09-22
Active, closed
Phase 2a to Evaluate PL-8177 in Subjects with Active Ulcerative Colitis (UC)
NCT05466890Ulcerative Colitis, Ulcerative Colitis Acute, Ulcerative, Ulcerative Colitis Flare
Palatin Technologies, Inc
Phase 2
16
Arizona, California, Florida, Kansas, Louisiana, New Jersey, New York, Pennsylvania
2022-09-15
Active, closed
XIENCE Skypoint Large Vessel Post Approval Study
NCT05423379Coronary Artery Disease
Abbott Medical Devices
Observational
102
Arkansas, Florida, Kansas, Nebraska, New York, Pennsylvania, South Carolina, Texas
2022-09-14
Recruiting
Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.
NCT05422911Metastatic Cancer, Neoplasm, Prostate, Castrate-sensitive, Castrate-sensitive Prostate Cancer
DrugsZytiga·Apalutamide·Xtandi·Abiraterone acetate
Sun Pharmaceutical Industries Limited
Phase 2
192
California, Florida, Michigan, Missouri, New York, North Carolina, Oregon, Pennsylvania
2022-08-31
Active, closed
Study to Evaluate Safety and Dosimetry of Lutathera in Adolescent Patients With GEP-NETs and PPGLs
NCT04711135Gastroenteropancreatic Neuroendocrine Tumors, Pheochromocytoma, Paraganglioma
DrugsLutetium [177Lu] oxodotreotide/dotatate·Lutathera
Advanced Accelerator Applications
Phase 2
11
Kentucky, Ohio, Pennsylvania
2022-08-31
Active, closed
Safety, Tolerability and PK of Subcutaneous D-4517.2 in Subjects With Wet AMD or DME
NCT05387837Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
DrugAflibercept
Ashvattha Therapeutics, Inc.
Phase 2
50
California, Illinois, Indiana, Maryland, Massachusetts, Missouri, New Jersey, Pennsylvania
2022-08-31
Recruiting
Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears
NCT05444465Rotator Cuff Injuries
Smith & Nephew, Inc.
Not applicable
234
Georgia, Illinois, Maryland, Ohio, Pennsylvania, Texas, Wisconsin
2022-08-30
Recruiting
Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer
NCT05455619HR+/HER2-negative Breast Cancer, Metastatic Breast Cancer
SynDevRx, Inc.
Phase 1/2
52
California, Florida, Illinois, Michigan, Ohio, Pennsylvania, Tennessee, Texas
2022-08-26
Recruiting
A Prospective Sub-Study of the Global Hypophosphatasia Registry
NCT05234567Hypophosphatasia
DrugAsfotase alfa
Alexion Pharmaceuticals, Inc.
Observational
30
Connecticut, Illinois, Massachusetts, Missouri, New York, Ohio, Pennsylvania, Tennessee
2022-08-25
By invitation
A Long-Term Safety Follow-Up Study for Patients Treat With WU-CART-007
NCT05509855T-cell Acute Lymphoblastic Leukemia, T-cell Lymphoblastic Lymphoma
Allotera Therapeutics
Observational
44
California, Missouri, Pennsylvania
2022-08-22
Active, closed
Study of the CycloPen Micro-Interventional System and Long-Term Clinical Outcomes
NCT05506423Open Angle Glaucoma
Iantrek, Inc.
Observational
300
California, Florida, Georgia, Maryland, Nevada, New Jersey, New York, Pennsylvania
2022-08-17
Active, closed
Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-251 in Participants With Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping
NCT05524883Duchenne Muscular Dystrophy (DMD)
DrugZeleciment Rostudirsen
Dyne Therapeutics
Phase 1/2
86
California, Colorado, Georgia, Massachusetts, Ohio, Oregon, Pennsylvania, Utah
2022-08-12
Active, closed
A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma
NCT05421663Lymphoma, Non-Hodgkin, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse
Janssen Research & Development, LLC
Phase 1/2
166
California, Colorado, Iowa, Kentucky, New Jersey, North Carolina, Ohio, Pennsylvania
2022-08-12
Active, closed
Long-Term Follow-up Study of ADVM-022 in DME (INFINITY-EXT)
NCT05607810Diabetic Macular Edema, Diabetic Retinopathy
Adverum Biotechnologies, Inc.
Observational
22
California, Nevada, Pennsylvania, Texas
2022-08-10
Active, closed
A Study on the Long-term Efficacy, Safety and Persistence of Immune Response of a Vaccine Against Herpes Zoster in Older Adults
NCT05371080Herpes Zoster
GlaxoSmithKline
Phase 3
3,038
Arizona, Maryland, North Carolina, Pennsylvania, Tennessee, Texas, Utah
2022-08-10
Active, closed
First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors
NCT05489237Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumor (GIST), Digestive System Disease, Gastrointestinal Diseases
DrugIDRX-42
IDRX, Inc., a wholly owned subsidiary of GSK, LLC
Phase 1
276
Florida, Illinois, Massachusetts, Missouri, New York, Oregon, Pennsylvania, Texas
2022-08-03
Active, closed
A Study to Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)
NCT05092347Chronic Kidney Disease (CKD)
DrugVonsetamig
Regeneron Pharmaceuticals
Phase 1/2
43
California, Connecticut, District of Columbia, Illinois, Maryland, Minnesota, New York, Pennsylvania
2022-08-02
Recruiting
A Prospective Registry to Enable Collection of Standardized Routine Care Oncology Patient Data
NCT06877884Cancer
N-Power Medicine
Observational
20,000
California, Delaware, Illinois, New Mexico, Pennsylvania, Texas
2022-08-01
Recruiting
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT05254743Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma
DrugsPirtobrutinib·Ibrutinib
Loxo Oncology, Inc.
Phase 3
737
California, Florida, Louisiana, Maryland, Montana, Pennsylvania, South Carolina, Tennessee
2022-07-22
Active, closed
A Study to Determine the Efficacy and Safety of Tividenofusp Alfa (DNL310) vs Idursulfase in Pediatric and Young Adult Participants With Neuronopathic (nMPS II) or Non-Neuronopathic Mucopolysaccharidosis Type II (nnMPS II)
NCT05371613Mucopolysaccharidosis II
DrugsIdursulfase·Tividenofusp alfa
Denali Therapeutics Inc.
Phase 2/3
65
California, Illinois, New Jersey, North Carolina, Ohio, Pennsylvania, Texas, Utah
2022-07-21
Recruiting
A Study of Nipocalimab in Children Aged 2 to Less Than 18 Years With Generalized Myasthenia Gravis
NCT05265273Myasthenia Gravis
DrugNipocalimab
Janssen Research & Development, LLC
Phase 2/3
12
Arizona, California, Colorado, Florida, Kansas, Michigan, Pennsylvania
2022-07-20
Recruiting
A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
NCT05361174Unresectable Melanoma, Metastatic Melanoma, Stage III Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
Iovance Biotherapeutics, Inc.
Phase 1/2
53
California, Florida, Kansas, Kentucky, New York, Ohio, Pennsylvania, Wisconsin
2022-07-20
Active, closed
Long-term Follow-up Study of Patients Who Received hLB-001 Gene Therapy
NCT05506254Methylmalonic Acidemia
Alexion Pharmaceuticals, Inc.
Observational
4
Georgia, Pennsylvania, Tennessee, Washington
2022-07-15
Recruiting
Otoferlin Gene-mediated Hearing Loss Natural History Study
NCT05572073Sensorineural Hearing Loss, Bilateral
Akouos, Inc.
Observational
150
Iowa, Ohio, Pennsylvania, Tennessee
2022-07-14
Active, closed
Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)
NCT05263934Eosinophilic Granulomatosis With Polyangiitis
DrugsDepemokimab·Mepolizumab
GlaxoSmithKline
Phase 3
163
Colorado, Florida, Minnesota, New York, North Carolina, Pennsylvania
2022-07-14
Recruiting
A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas
NCT05475925LGLL - Large Granular Lymphocytic Leukemia, Primary Cutaneous Gamma-Delta T-Cell Lymphoma, Primary Cutaneous CD8+ Aggressive Epidermotropic T-Cell Lymphoma, Hepatosplenic T-cell Lymphoma
DrugDibotatug
Dren Bio
Phase 1/2
200
Alabama, California, Connecticut, Florida, Massachusetts, New York, Ohio, Pennsylvania
2022-07-13
Active, closed
A Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed ES-SCLC Patients in Combination With Carboplatin, Etoposide and Atezolizumab
NCT05142696Extensive Stage Small Cell Lung Cancer
Drugs[177Lu]Lu-DOTA-TATE·[68Ga]Ga-DOTA-TATE·Lutathera·Atezolizumab
Novartis Pharmaceuticals
Phase 1/2
55
Florida, Georgia, Kentucky, Missouri, New Jersey, Ohio, Pennsylvania
2022-07-13
Recruiting
A Study to Evaluate PEEL-224 in Patients With Advanced Solid Tumors
NCT05329103Advanced Solid Tumor
Peel Therapeutics Inc
Phase 1
65
Arizona, California, North Carolina, Pennsylvania, Rhode Island, Texas, Utah, Virginia
2022-07-11
Active, closed
PDN Post Market, Multicenter, Prospective, Global Clinical Study
NCT05301816Diabetic Neuropathy, Painful
Nevro Corp
Not applicable
497
Alaska, Michigan, Ohio, Oklahoma, Oregon, Pennsylvania, Virginia
2022-07-05
Active, closed
Study of INCB123667 in Subjects With Advanced Solid Tumors
NCT05238922Solid Tumors
DrugsRibociclib·Palbociclib·Olaparib·Fulvestrant
Incyte Corporation
Phase 1
291
California, Colorado, Connecticut, Florida, Georgia, New York, North Carolina, Pennsylvania
2022-07-05
Active, closed
A Trial to Assess the Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With PLD
NCT05281328Polycystic Liver Disease
DrugCAM2029
Camurus AB
Phase 2/3
71
Minnesota, New York, Pennsylvania, Texas, Virginia
2022-06-28
Active, closed
Efficacy and Safety Study of Ravulizumab IV in Pediatric Participants With NMOSD
NCT05346354Neuromyelitis Optica Spectrum Disorder
DrugsUltomiris·Ravulizumab
Alexion Pharmaceuticals, Inc.
Phase 2/3
12
District of Columbia, Florida, Massachusetts, North Carolina, Pennsylvania
2022-06-23
Active, closed
A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period
NCT05144256Pediatric Pyruvate Kinase Deficiency, Pediatric Hemolytic Anemia
DrugMitapivat
Agios Pharmaceuticals, Inc.
Phase 3
49
Arizona, California, Georgia, Massachusetts, Nevada, New York, Pennsylvania, Texas
2022-06-08
Recruiting
A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace)
NCT05813678Phenylketonuria (PKU)
DrugPegvaliase
BioMarin Pharmaceutical
Observational
450
Colorado, Georgia, Illinois, Indiana, Louisiana, Massachusetts, Oregon, Pennsylvania
2022-06-06
Active, closed
A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Not Regularly Transfused, Followed by a 5-Year Extension Period
NCT05175105Pediatric Pyruvate Kinase Deficiency, Pediatric Hemolytic Anemia
DrugMitapivat
Agios Pharmaceuticals, Inc.
Phase 3
30
California, Colorado, Georgia, Illinois, Massachusetts, Michigan, North Carolina, Pennsylvania
2022-06-06
Active, closed
A Study of mRNA-3745 in Adult and Pediatric Participants With Glycogen Storage Disease Type 1a (GSD1a)
NCT05095727Glycogen Storage Disease
ModernaTX, Inc.
Phase 1/2
15
Connecticut, Massachusetts, North Carolina, Ohio, Pennsylvania, Texas, Utah
2022-06-01
Recruiting
S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Advanced or Metastatic Solid Tumors
NCT05101070Solid Tumors
DrugsAvastin·Keytruda·Bevacizumab·Pembrolizumab
Shionogi
Phase 1/2
282
California, Florida, Michigan, Pennsylvania, Texas
2022-05-30
Active, closed
Effect of Ensifentrine on Sputum Markers of Inflammation in COPD
NCT05270525COPD
Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA
Phase 2
56
Alabama, Michigan, Pennsylvania
2022-05-27
Active, closed
A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-remitting Multiple Sclerosis (RRMS)
NCT05123703Relapsing-remitting Multiple Sclerosis
DrugsFingolimod·Ocrelizumab
Hoffmann-La Roche
Phase 3
188
California, Colorado, District of Columbia, Maryland, Massachusetts, Missouri, Ohio, Pennsylvania
2022-05-19
Active, closed
A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.
NCT05109728Glioblastoma
Drugs[177Lu]Lu-DOTA-TATE·[68Ga]Ga-DOTA-TATE·Lutathera
Novartis Pharmaceuticals
Phase 1
63
New York, Pennsylvania, Texas, Wisconsin
2022-05-10
By invitation
Posterior Cervical Fixation Study
NCT04770571Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease
NuVasive
Observational
150
California, Connecticut, Maryland, New York, Pennsylvania, Tennessee, Texas
2022-05-10
Active, closed
RAdiolabeled Perfusion to Identify Coronary Artery Disease Using WAter To Evaluate Responses of Myocardial FLOW (RAPID-WATER-FLOW)
NCT05134012Coronary Artery Disease
MedTrace Pharma A/S
Phase 3
215
Iowa, Minnesota, Missouri, Pennsylvania, Texas, Virginia
2022-05-08
Recruiting
To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva
NCT05090891Fibrodysplasia Ossificans Progressiva (FOP)
Incyte Corporation
Phase 2
98
Minnesota, Pennsylvania
2022-05-05
Active, closed
HM15136 (Efpegerglucagon) Treatment for 8 Weeks in Subjects Aged ≥2 Years With Congenital Hyperinsulinism (CHI)
NCT04732416Congenital Hyperinsulinism
Hanmi Pharmaceutical Company Limited
Phase 2
17
Pennsylvania
2022-05-05
Recruiting
Daily Adaptive Radiation Therapy an Individualized Approach for Carcinoma of the Cervix
NCT05197881Cervical Cancer by FIGO Stage 2018
Varian, a Siemens Healthineers Company
Not applicable
125
Alabama, Arkansas, California, Pennsylvania, Texas
2022-05-03
Active, closed
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)
NCT05329649Sickle Cell Disease, Hydroxyurea Failure, Hydroxyurea Intolerance, Hemoglobinopathies
DrugExa-cel
Vertex Pharmaceuticals Incorporated
Phase 3
13
North Carolina, Pennsylvania, Tennessee
2022-05-02
Active, closed
EDIT-301 for Autologous Hematopoietic Stem Cell Transplant (HSCT) in Participants With Transfusion-Dependent Beta Thalassemia (TDT)
NCT05444894Transfusion Dependent Beta Thalassemia, Hemoglobinopathies, Thalassemia Major, Thalassemia Intermedia
Editas Medicine, Inc.
Phase 1/2
9
California, Minnesota, New York, Ohio, Pennsylvania, Tennessee
2022-04-29
Active, closed
COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
NCT05035823Neurologic Disorder, Paralysis, Paralysis; Stroke, Amyotrophic Lateral Sclerosis
Synchron Medical, Inc.
Not applicable
6
New York, Pennsylvania
2022-04-27
Recruiting
Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System
NCT05406167Cancer, Cancer Central Nervous System, Cancer Thoracic, Cancer, Gastrointestinal
RefleXion Medical
Observational
500
California, Connecticut, Pennsylvania, Texas
2022-04-12
Recruiting
Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry
NCT04829175Stress Urinary Incontinence, Pelvic Organ Prolapse
Ethicon, Inc.
Observational
1,000
Connecticut, North Carolina, Pennsylvania
2022-04-11
Recruiting
Study of SFA002 in Patients with Mild to Moderate Psoriasis Plaques
NCT05642182Psoriasis
SFA Therapeutics
Phase 1
90
Florida, North Dakota, Pennsylvania
2022-03-31
Active, closed
LF111 or Drospirenone Chew vs Non-hormonal Contraceptive Methods on Bone Mineral Density in Adolescent and Adult Women
NCT05303636Change in Bone Mineral Density, Bone Loss
DrugDrospirenone
Insud Pharma
Phase 4
1,536
Arizona, Colorado, Florida, Louisiana, Michigan, Nebraska, North Dakota, Pennsylvania
2022-03-28
Active, closed
Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)
NCT05224141Small Cell Lung Carcinoma
DrugsPembrolizumab/Vibostolimab·Tecentriq·Paraplatin·Etoposide
Merck Sharp & Dohme LLC
Phase 3
460
Alabama, California, Florida, Indiana, Massachusetts, Michigan, Mississippi, Pennsylvania
2022-03-24
Active, closed
First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors
NCT05277051Neoplasms
DrugsRemzistotug·GSK5764227·Nelistotug·Belrestotug
GlaxoSmithKline
Phase 1
152
California, North Carolina, Oklahoma, Pennsylvania, Texas, Utah
2022-03-22
Active, closed
A Study to Evaluate the Effect of Venglustat Tablets on Neuropathic and Abdominal Pain in Male and Female Participants ≥16 Years of Age With Fabry Disease
NCT05206773Fabry Disease
DrugVenglustat
Sanofi
Phase 3
122
Alabama, California, Florida, Georgia, New York, Ohio, Pennsylvania, Texas
2022-03-11
Active, closed
Cardiac Implantable Electronic Device (CIED) Research Study
NCT05061862Arrhythmias, Cardiac, Bradycardia, Tachycardia
Medtronic Cardiac Rhythm and Heart Failure
Observational
1,000
Florida, Georgia, Oregon, Pennsylvania, Virginia
2022-03-06
Recruiting
Trisol System EFS Study
NCT04905017Tricuspid Regurgitation
Trisol Medical
Not applicable
30
California, Georgia, New York, Ohio, Pennsylvania, Tennessee, Virginia
2022-03-02
Active, closed
A Phase III Study of JR-141 in Patients With Mucopolysaccharidosis II (STARLIGHT)
NCT04573023Mucopolysaccharidosis II
DrugsIdursulfase·JR-141
JCR Pharmaceuticals Co., Ltd.
Phase 3
86
Arizona, California, Illinois, Minnesota, New York, North Carolina, Pennsylvania
2022-02-14
Active, closed
Insignia™ Hip Stem Outcomes Study
NCT05144191Hip Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Post-traumatic Osteoarthritis
Stryker Orthopaedics
Not applicable
313
Arizona, California, Illinois, Nevada, New York, North Carolina, Pennsylvania, Tennessee
2022-02-07
Active, closed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)
NCT05262023Frontotemporal Dementia
Denali Therapeutics Inc.
Phase 1/2
85
California, Maryland, Pennsylvania
2022-02-01
Active, closed
Study to Assess the Safety and Efficacy of OCU400 for Retinitis Pigmentosa and Leber Congenital Amaurosis
NCT05203939Retinitis Pigmentosa, Leber Congenital Amaurosis
Ocugen
Phase 1/2
22
Arizona, California, Florida, Georgia, Oregon, Pennsylvania, Texas
2022-01-24
Active, closed
Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN
NCT05309668Neurofibromatosis Type 1
DrugSelumetinib
AstraZeneca
Phase 1/2
36
Ohio, Pennsylvania, Texas, Virginia
2022-01-21
Active, closed
A Study to Learn About the Effect of Higher Doses of Nusinersen (BIIB058) Given as Injections to Participants With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Risdiplam (ASCEND)
NCT05067790Spinal Muscular Atrophy
DrugNusinersen
Biogen
Phase 3
45
Arizona, California, Georgia, Massachusetts, Michigan, New York, North Carolina, Pennsylvania
2022-01-21
Recruiting
Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics
NCT05490888Cirrhosis, Liver, Liver Fibrosis, Ascites Hepatic
PharmaIN
Phase 1
74
Arizona, California, Louisiana, Minnesota, Ohio, Pennsylvania, Texas
2022-01-03
Recruiting
The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease
NCT07618364Dry Eye Syndromes, Dry Eye, Ocular Surface Disease
Rinsada
Not applicable
33
Pennsylvania
2022-01-01
Recruiting
Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia
NCT04925479Myeloid Leukemia, Philadelphia Positive
DrugABL001
Novartis Pharmaceuticals
Phase 1/2
34
Indiana, Massachusetts, Mississippi, New York, Ohio, Pennsylvania, Texas, Utah
2021-12-27
Active, closed
Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer
NCT04905069Prostate Cancer
Boston Scientific Corporation
Not applicable
500
Florida, Kansas, Michigan, New Jersey, Pennsylvania, South Carolina
2021-12-21
Active, closed
A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)
NCT04819100Carcinoma, Non-Small-Cell Lung
DrugSelpercatinib
Eli Lilly and Company
Phase 3
152
California, Florida, Massachusetts, Minnesota, New York, Pennsylvania, Tennessee, Texas
2021-12-20
Active, closed
A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT)
NCT04770753Non-Transfusion-dependent Alpha-Thalassemia, Non-Transfusion-dependent Beta-Thalassemia
DrugMitapivat
Agios Pharmaceuticals, Inc.
Phase 3
194
California, Massachusetts, New York, North Carolina, Pennsylvania
2021-12-20
Active, closed
A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis
NCT05070858Generalized Myasthenia Gravis
DrugsCemdisiran·Pozelimab
Regeneron Pharmaceuticals
Phase 3
288
Arizona, California, Colorado, Florida, Illinois, Michigan, Ohio, Pennsylvania
2021-12-14
Active, closed
BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)
NCT04982393Primary Hyperoxaluria Type 1
Alnylam Pharmaceuticals
Observational
207
Arizona, District of Columbia, Massachusetts, Minnesota, Ohio, Pennsylvania, Texas
2021-12-13
Recruiting
Pediatric Post-Approval Registry
NCT04457154Obstructive Sleep Apnea
Inspire Medical Systems, Inc.
Observational
60
Colorado, Georgia, North Carolina, Ohio, Pennsylvania, Texas, Virginia
2021-11-30
Active, closed
A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)
NCT04770779Transfusion-dependent Alpha-Thalassemia, Transfusion-dependent Beta-Thalassemia
DrugMitapivat
Agios Pharmaceuticals, Inc.
Phase 3
258
Arizona, California, Massachusetts, Michigan, New York, North Carolina, Pennsylvania, Washington
2021-11-30
Active, closed
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS)
NCT05130450Familial Chylomicronemia Syndrome
DrugOlezarsen
Ionis Pharmaceuticals, Inc.
Phase 3
60
California, Florida, Illinois, Kansas, New York, Pennsylvania
2021-11-18
Recruiting
Open-Label Extension Study of Marstacimab in Hemophilia Participants With or Without Inhibitors
NCT05145127Hemophilia A, Hemophilia B
DrugMarstacimab
Pfizer
Phase 3
245
Iowa, New York, Pennsylvania, Washington
2021-11-17
Recruiting
Knee Related Subchondral Bone Lesions Treated With IOBP
NCT05314608Subchondral Cyst
Arthrex, Inc.
Observational
100
Colorado, Florida, Maryland, Ohio, Pennsylvania
2021-11-17
Active, closed
A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders
NCT05112861Age-Related Macular Degeneration, Neovascular Age-related Macular Degeneration, Wet Macular Degeneration, BRVO - Branch Retinal Vein Occlusion
DrugBevacizumab
Outlook Therapeutics, Inc.
Phase 3
120
Illinois, Maryland, Pennsylvania
2021-11-15
Active, closed
Investigation of Remimazolam in Children Undergoing Sedation for Medical Procedures
NCT04851717Pediatric ALL
DrugRemimazolam
Acacia Pharma Ltd
Phase 2/3
100
California, Massachusetts, Minnesota, Pennsylvania, Texas
2021-11-15
Recruiting
Ceribell Delirium Data Collection Study
NCT04962815Delirium
Ceribell Inc.
Observational
200
California, Florida, Iowa, Missouri, New Jersey, North Carolina, Pennsylvania
2021-11-10
Recruiting
A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study
NCT05130437Propionic Acidemia
DrugMRNA-3927
ModernaTX, Inc.
Phase 1/2
50
California, Michigan, New York, North Carolina, Pennsylvania, Texas
2021-11-09
Active, closed
Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression
NCT05163041Advanced Solid Tumor
DrugNivolumab
BicycleTx Limited
Phase 1/2
200
Iowa, New York, Ohio, Pennsylvania, Texas, Virginia
2021-11-02
Active, closed
A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations
NCT05048797Locally Advanced or Metastatic Non-Small Cell Lung Cancer
DrugsTrastuzumab deruxtecan·Pemetrexed·Cisplatin·Carboplatin
AstraZeneca
Phase 3
454
Alaska, California, Maryland, Massachusetts, Michigan, New Jersey, New York, Pennsylvania
2021-10-28
Active, closed
Post Market Clinical Follow-Up Study in Patients Treated With the On-X Ascending Aortic Prosthesis (AAP)
NCT05082454Aortic Valve Disease
JOTEC GmbH
Observational
108
Pennsylvania, Texas, Virginia
2021-10-20
Recruiting
ConsideRAte Study - Splenic Stimulation for RA
NCT05003310Rheumatoid Arthritis
DrugBaricitinib
Galvani Bioelectronics
Not applicable
28
Alabama, California, Maryland, New York, Oregon, Pennsylvania, Texas
2021-10-19
By invitation
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs
NCT04930289Interstitial Lung Disease, COPD, Cystic Fibrosis, Pulmonary Fibrosis
Paragonix Technologies
Observational
3,500
Arizona, California, Florida, Maryland, Massachusetts, New York, North Carolina, Pennsylvania
2021-10-15
Active, closed
A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma
NCT05083169Multiple Myeloma
DrugsTeclistamab·Pomalidomide·Bortezomib·Daratumumab
Janssen Research & Development, LLC
Phase 3
587
Alabama, California, Connecticut, Georgia, Massachusetts, Michigan, Ohio, Pennsylvania
2021-10-14
Active, closed
Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis
NCT04926818Multiple Sclerosis (MS)
DrugsSiponimod·Fingolimod·Ofatumumab
Novartis Pharmaceuticals
Phase 3
129
Arkansas, California, District of Columbia, Florida, Pennsylvania, Wisconsin
2021-10-05
Active, closed
Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing
NCT05059522Advanced Malignancies, NSCLC, Ovarian Cancer, Urothelial Cancer
DrugsCMP 001·Utomilumab·Talazoparib·Axitinib
Pfizer
Phase 3
77
Arkansas, California, Florida, New Jersey, New York, Pennsylvania, Texas, Washington
2021-09-29
Active, closed
A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes
NCT04747431Frontotemporal Dementia, FTD, FTD-GRN, Dementia Frontotemporal
Passage Bio, Inc.
Phase 1/2
30
Michigan, Pennsylvania, Tennessee, Texas
2021-09-14
Recruiting
Helix Research Network
NCT06057181Genetic Predisposition to Disease, Genetics Disease
Helix, Inc
Observational
2,000,000
Indiana, Minnesota, Nebraska, Nevada, New York, North Carolina, Ohio, Pennsylvania
2021-09-13
Recruiting
Post Market Clinical Follow-up Study on TVT ABBREVO® Continence System
NCT04829357Stress Urinary Incontinence
Ethicon, Inc.
Observational
195
Pennsylvania
2021-09-09
Recruiting
Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation
NCT04890613Advanced Solid Tumor
Senhwa Biosciences, Inc.
Phase 1
52
California, Florida, Massachusetts, New York, Ohio, Pennsylvania
2021-09-08
Active, closed
A Study of ARV-766 Given by Mouth in Men With Metastatic Prostate Cancer
NCT05067140Prostate Cancer Metastatic
DrugsLuxdegalutamide·Abiraterone·Prednisolone·Prednisone
Novartis Pharmaceuticals
Phase 1/2
164
California, Connecticut, Florida, Maryland, Massachusetts, Michigan, New York, Pennsylvania
2021-09-02
Active, closed
REFLECTION: A Clinical Practice Learning Program for Galleri®
NCT05205967Early Detection of Cancer, Cancer
GRAIL, Inc.
Observational
14,633
Arizona, California, Florida, Louisiana, Massachusetts, Oregon, Pennsylvania, South Carolina
2021-08-23
Recruiting
Safety and Efficacy of Tideglusib in Congenital or Childhood Onset Myotonic Dystrophy
NCT05004129Congenital Myotonic Dystrophy
DrugTideglusib
AMO Pharma Limited
Phase 2/3
76
Arkansas, California, Illinois, Iowa, New York, Pennsylvania, Utah, Virginia
2021-08-23
Active, closed
Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)
NCT04938817Small Cell Lung Carcinoma
DrugsMK-4830·Pembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab·R-DXd
Merck Sharp & Dohme LLC
Phase 1/2
110
Arizona, Georgia, Indiana, Kentucky, Maryland, Nebraska, Ohio, Pennsylvania
2021-08-19
By invitation
A Study Evaluating Oral Eluxadoline Administered to Pediatric Participants With Irritable Bowel Syndrome With Diarrhea (IBS-D)
NCT04880876Irritable Bowel Syndrome
AbbVie
Phase 3
124
California, Florida, Georgia, Oklahoma, Pennsylvania
2021-08-13
Active, closed
Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
NCT04624230Ulcerative Colitis
DrugTofacitinib
Pfizer
Phase 3
118
California, Connecticut, Florida, Georgia, Massachusetts, New York, Ohio, Pennsylvania
2021-08-12
Active, closed
Virtual Incision Robotically Assisted Surgical Device Use in Minimally Invasive Colectomy
NCT04703829Colon Cancer, Colon Polyp, Diverticular Diseases, Inflammatory Bowel Diseases
Virtual Incision Corporation
Not applicable
30
Nebraska, Pennsylvania, South Carolina
2021-08-09
Active, closed
US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair
NCT04852783Aneurysm, Intracranial
Cerus Endovascular, Inc.
Phase 4
250
Colorado, Florida, Illinois, Kansas, Massachusetts, New York, North Carolina, Pennsylvania
2021-08-06
Active, closed
MIRACLE of LIFE Study
NCT06074601Preterm Labor, Preterm Birth, Preterm Birth Complication, Preterm Premature Rupture of Membrane
Mirvie
Observational
10,000
California, Florida, Louisiana, Massachusetts, Missouri, Ohio, Pennsylvania, Texas
2021-08-01
Active, closed
Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies
NCT04541108Solid Tumor
DrugsAZD9592·Sabestomig·Volrustomig·Rilvegostomig
Presage Biosciences
Phase EARLY_PHASE1
15
Louisiana, New York, North Carolina, Ohio, Oregon, Pennsylvania, South Carolina, Washington
2021-07-26
Recruiting
Valved Graft PMCF Study
NCT04754217Aortic Valve Disease, Ascending Aorta Abnormality, Aortic Dissection
Abbott Medical Devices
Observational
260
Alabama, Michigan, North Carolina, Pennsylvania
2021-07-13
Active, closed
Post-Market Clinical Follow-Up onTVT EXACT® Continence System
NCT04829994Stress Urinary Incontinence
Ethicon, Inc.
Observational
198
North Carolina, Pennsylvania
2021-07-07
Active, closed
Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting
NCT04900844Carotid Artery Stenosis
InspireMD
Not applicable
317
Florida, Louisiana, Michigan, Missouri, New York, North Carolina, Ohio, Pennsylvania
2021-07-01
Active, closed
A Study of Gene Therapy for Classic Congenital Adrenal Hyperplasia (CAH)
NCT04783181Congenital Adrenal Hyperplasia
Adrenas Therapeutics Inc
Phase 1/2
8
Illinois, Maryland, Minnesota, North Carolina, Pennsylvania
2021-07-01
Recruiting
CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting
NCT05002543Cardiac Valve Disease
Corcym S.r.l
Observational
2,150
Indiana, Louisiana, Maine, North Carolina, Ohio, Pennsylvania
2021-06-29
Active, closed
Phase 1/2 Clinical Trial of PR001 in Infants With Type 2 Gaucher Disease (PROVIDE)
NCT04411654Gaucher Disease, Type 2
DrugsSirolimus·Methylprednisolone·Prednisone
Prevail Therapeutics
Phase 1/2
7
California, Minnesota, New York, Pennsylvania, Virginia
2021-06-29
Active, closed
Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease
NCT04915755Neoplasms, Breast
DrugNiraparib
GlaxoSmithKline
Phase 3
40
California, Colorado, Illinois, Michigan, New Mexico, New York, North Dakota, Pennsylvania
2021-06-28
Active, closed
Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).
NCT04895722Colorectal Cancer
DrugsPembrolizumab/Vibostolimab·MK-4830·Pembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab
Merck Sharp & Dohme LLC
Phase 2
302
Florida, Georgia, Illinois, New York, Pennsylvania, Tennessee, Texas, Washington
2021-06-25
Active, closed
Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial.
NCT04925024Hypoplastic Left Heart Syndrome
Longeveron Inc.
Phase 2
40
California, Colorado, Georgia, Illinois, Massachusetts, Nebraska, Ohio, Pennsylvania
2021-06-25
Active, closed
Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea
NCT04801771Down Syndrome, Obstructive Sleep Apnea
Inspire Medical Systems, Inc.
Not applicable
57
Georgia, Massachusetts, Ohio, Pennsylvania, Texas, Virginia, Wisconsin
2021-06-24
Recruiting
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer
NCT04802759Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer
DrugsSamuraciclib·Ipatasertib·Giredestrant·Phesgo
Hoffmann-La Roche
Phase 1/2
316
California, Massachusetts, New Jersey, North Carolina, Pennsylvania, Tennessee
2021-06-22
By invitation
Long-Term Follow-Up of Patients Who Received Gene-Modified Cell Therapy
NCT05472649Long-term Follow-up
Sorrento Therapeutics, Inc.
Observational
1
Pennsylvania
2021-06-16
Recruiting
Device Global Registry for the IlluminOss Bone Stabilization System
NCT05206981Traumatic Fracture, Pathological Fracture
IlluminOss Medical, Inc.
Observational
300
Alabama, California, Colorado, Florida, Indiana, New York, North Carolina, Pennsylvania
2021-06-11
Recruiting
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study
NCT04657822Sickle Cell Disease
DrugCrizanlizumab
Novartis Pharmaceuticals
Phase 4
130
Alabama, District of Columbia, Georgia, North Carolina, Pennsylvania, Texas
2021-06-10
Active, closed
da Vinci SP® Investigational Device Exemption Study in Colorectal Procedures
NCT04403022Colorectal Cancer, Benign or Malignant Rectal or Colon Tumors
Intuitive Surgical
Not applicable
60
Florida, Michigan, Minnesota, Nevada, Pennsylvania, Texas, Washington
2021-06-03
Active, closed
Persona Ti-Nidium Post-Market Clinical Follow-up
NCT04817969Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
Zimmer Biomet
Not applicable
240
Colorado, Maryland, Mississippi, New Mexico, North Carolina, Pennsylvania, South Dakota
2021-06-01
Active, closed
A Study to Evaluate the Safety and Efficacy of Zilganersen (ION373) in Patients With Alexander Disease (AxD)
NCT04849741Alexander Disease
Ionis Pharmaceuticals, Inc.
Phase 3
54
California, Georgia, Massachusetts, Pennsylvania
2021-06-01
Recruiting
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
NCT04844606Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
DrugMirikizumab
Eli Lilly and Company
Phase 3
150
California, Connecticut, Georgia, Massachusetts, Missouri, New York, Pennsylvania, Texas
2021-05-26
Recruiting
A Study of BGB-11417 in Participants With Myeloid Malignancies
NCT04771130Acute Myeloid Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasm
DrugsPosaconazole·Sonrotoclax·Azacitidine
BeOne Medicines
Phase 1/2
260
California, Florida, Pennsylvania, Texas, Wisconsin
2021-05-24
Active, closed
A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advanced or Has Spread
NCT04810078Clear Cell Renal Cell Carcinoma
DrugsNivolumab and rHuPH20·Opdivo·Nivolumab
Bristol-Myers Squibb
Phase 3
681
Illinois, New York, Pennsylvania
2021-05-21
Active, closed
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy
NCT04660344Muscle-invasive Bladder Cancer
DrugsTecentriq·Atezolizumab
Hoffmann-La Roche
Phase 3
761
Florida, Ohio, Pennsylvania
2021-05-03
Recruiting
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
NCT04752774Spasticity
DrugsDysport·Corabotase
Ipsen
Phase 1/2
240
California, Kansas, Michigan, Pennsylvania, Texas
2021-04-29
Active, closed
A Study of the Natural History of Participants With LGMD2E/R4, LGMD2D/R3, LGMD2C/R5, and LGMD2A/R1 ≥ 4 Years of Age, Who Are Managed in Routine Clinical Practice
NCT04475926Limb-girdle Muscular Dystrophy
Sarepta Therapeutics, Inc.
Observational
205
Arizona, Arkansas, California, Illinois, Ohio, Oregon, Pennsylvania, Texas
2021-04-22
Active, closed
Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum
NCT04589650PIK3CA-related Overgrowth Spectrum (PROS)
DrugAlpelisib
Novartis Pharmaceuticals
Phase 2
206
California, Colorado, Missouri, New York, North Carolina, Ohio, Pennsylvania, Texas
2021-04-19
Recruiting
A Safety, Tolerability, and Efficacy Study of VX-880 and VX-017 in Participants With Type 1 Diabetes
NCT04786262Diabetes Mellitus, Type 1, Impaired Hypoglycemic Awareness, Severe Hypoglycemia
DrugZimislecel
Vertex Pharmaceuticals Incorporated
Phase 3
57
California, Florida, Illinois, Maryland, Massachusetts, Pennsylvania, Texas, Virginia
2021-03-29
Active, closed
Robotic-Assisted da Vinci System Prophylactic Nipple-Sparing Mastectomy
NCT03892980Nipple Sparing Mastectomy
Intuitive Surgical
Not applicable
145
Florida, Illinois, Minnesota, New York, Pennsylvania, Texas
2021-03-26
Recruiting
Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System
NCT04634916Kidney Disease, End-Stage, End-stage Renal Disease, Arteriovenous Fistula
C. R. Bard
Not applicable
220
California, Florida, Massachusetts, New York, North Carolina, Ohio, Pennsylvania, Tennessee
2021-03-26
Recruiting
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
NCT04373564Motor Function, Cognitive Function, Contrast Media
DrugsGadavist·Gadoterate meglumine·Gadobutrol
Guerbet
Phase 4
2,076
Arizona, Connecticut, Illinois, Massachusetts, Missouri, North Carolina, Pennsylvania, Texas
2021-03-24
Active, closed
A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)
NCT04817007Myelofibrosis
DrugsBMS-986158·Fedratinib·Ruxolitinib
Bristol-Myers Squibb
Phase 1/2
216
California, Florida, Louisiana, Massachusetts, Michigan, New Jersey, North Carolina, Pennsylvania
2021-03-22
Active, closed
Validation of Genomic Immune-phenotyping Profiles to Predict Risk of Kidney Transplant Rejection
NCT04727788Kidney Transplant Rejection
Verici Dx
Observational
550
Illinois, Maryland, Michigan, Nebraska, Ohio, Pennsylvania, Tennessee, Washington
2021-03-21
Active, closed
Study of Safety, Tolerability and Efficacy of PBGM01 in Pediatric Participants With GM1 Gangliosidosis
NCT04713475GM1 Gangliosidosis, GM1 Gangliosidosis, Type I, GM1 Gangliosidosis, Type 2, Beta-Galactosidase-1 (GLB1) Deficiency
Gemma Biotherapeutics
Phase 1/2
26
California, Minnesota, New Jersey, Pennsylvania
2021-03-17
Active, closed
Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease
NCT04639050Alzheimers Disease
DrugTrontinemab
Hoffmann-La Roche
Phase 1/2
241
Florida, Georgia, Michigan, Pennsylvania, Texas
2021-03-15
Active, closed
Long-term Follow-Up for RGX-121
NCT04597385Mucopolysaccharidosis II
REGENXBIO Inc.
Observational
27
California, New Jersey, Pennsylvania
2021-03-14
Active, closed
Performance and Safety of Exufiber Ag+ and Exufiber on Partial Thickness Burns
NCT04839523Partial-thickness Burn
Molnlycke Health Care AB
Not applicable
44
Arizona, California, District of Columbia, Florida, Massachusetts, Pennsylvania
2021-03-10
Recruiting
Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors
NCT04777994Advanced Solid Tumor Cancer
Calico Life Sciences LLC
Phase 1
248
Arizona, Connecticut, Maryland, Massachusetts, Michigan, New York, North Carolina, Pennsylvania
2021-03-09
Recruiting
Observational, Passive Surveillance Program to Collect Information on Women and Their Offspring Exposed to MenQuadfi® During Pregnancy, in United States (US)
NCT04843111Meningococcal Infection
Sanofi Pasteur, a Sanofi Company
Observational
50
Pennsylvania
2021-03-05
Active, closed
TH1902 in Patients With Advanced Solid Tumors
NCT04706962Solid Tumor, TNBC - Triple-Negative Breast Cancer, Hormone Receptor-positive Breast Cancer, Epithelial Ovarian Cancer
Theratechnologies
Phase 1
70
Michigan, Pennsylvania, Texas
2021-03-04
Active, closed
A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma
NCT04594642B-cell Non Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Follicular Lymphoma
DrugSurovatamig
AstraZeneca
Phase 1
226
Florida, Kentucky, New Jersey, North Carolina, Ohio, Pennsylvania, Texas, Wisconsin
2021-03-02
Recruiting
HeartStart HS1 Defibrillator* Event Registry
NCT04840797Sudden Cardiac Arrest
Heartstream US LLC
Observational
1,400
Pennsylvania
2021-02-25
Active, closed
Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
NCT04699188KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small-Cell Lung, Carcinoma, Colorectal, Cancer of Lung
DrugsTNO155·Opnurasib·Tislelizumab
Novartis Pharmaceuticals
Phase 1/2
344
Georgia, Massachusetts, Pennsylvania, Texas
2021-02-24
Active, closed
A Pivotal Study of Safety and Effectiveness of NanoKnife IRE for Stage 3 Pancreatic Cancer
NCT03899636Stage III Pancreatic Cancer
DrugModified FOLFIRINOX
Angiodynamics, Inc.
Phase 3
528
Florida, Illinois, Kentucky, Pennsylvania, Texas
2021-02-23
Recruiting
PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches
NCT04545502Aneurysm, Dissection, Aortic Root Aneurysm, Aortic Root Dissection
Vascutek Ltd.
Observational
2,000
Colorado, Florida, Indiana, North Carolina, Ohio, Pennsylvania, Virginia
2021-02-17
Active, closed
Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer
NCT04612751Advanced or Metastatic NSCLC
DrugsSabestomig·Volrustomig·Rilvegostomig·Dato-DXd
AstraZeneca
Phase 1
155
California, Missouri, New Jersey, Ohio, Pennsylvania, Texas, Virginia
2021-02-02
Active, closed
Phase 2 Study Evaluating Autologous CD30.CAR-T Cells in Patients With Relapsed/Refractory Hodgkin Lymphoma (CHARIOT)
NCT04268706Hodgkin Lymphoma, Adult, Hodgkin Disease Recurrent, Hodgkin Disease Refractory, Hodgkin Disease, Pediatric
DrugsCD30.CAR-T·Fludara·Bendamustine·Fludarabine
Tessa Therapeutics
Phase 2
97
California, Illinois, Pennsylvania, Tennessee, Texas
2021-02-01
Recruiting
BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)
NCT04752826Advanced Malignancies, Ovarian Cancer, T-cell Lymphoma, Melanoma
DrugsPembrolizumab KEYTRUDA·Paclitaxel
BioInvent International AB
Phase 1/2
250
California, New York, Pennsylvania
2021-01-25
By invitation
A Long-term Follow-up Study in Participants Who Received CTX001
NCT04208529Beta-Thalassemia, Thalassemia, Sickle Cell Disease, Hematologic Diseases
DrugExa-cel
Vertex Pharmaceuticals Incorporated
Phase 3
160
California, Illinois, New York, North Carolina, Pennsylvania, Tennessee, Texas
2021-01-20
Active, closed
A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL
NCT04521231B Cell Precursor Acute Lymphoblastic Leukemia
DrugBlinatumomab
Amgen
Phase 1/2
181
California, Illinois, Maryland, Michigan, New York, Pennsylvania, Tennessee, Texas
2021-01-04
Recruiting
Collection of Samples USOPTIVAL Study
NCT04792684Colorectal Cancer (CRC), Advanced Adenomas (AA)
Universal Diagnostics
Observational
1,300
California, Florida, Illinois, Louisiana, Massachusetts, New York, Pennsylvania, Tennessee
2020-12-30
Active, closed
Study of RP3 Monotherapy and RP3 in Combination With Nivolumab in Patients With Solid Tumours
NCT04735978Advanced Solid Tumor
DrugNivolumab
Replimune, Inc.
Phase 1
123
Iowa, Pennsylvania, Texas
2020-12-29
Active, closed
An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors
NCT04305795Recurrent Head and Neck Squamous Cell Carcinoma, Metastatic Head-and-neck Squamous-cell Carcinoma, Locally Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
DrugsCemiplimab·Pembrolizumab
Rakuten Medical, Inc.
Phase 1/2
23
Florida, Kentucky, Minnesota, Oregon, Pennsylvania, Tennessee, Texas
2020-12-21
Active, closed
Study to Evaluate the Efficacy, Safety and Tolerability of MAS825 in Patients With Monogenic IL-18 Driven Autoinflammatory Diseases, Including NLRC4-GOF, XIAP Deficiency, or CDC42 Mutations
NCT04641442NLRC4-GOF, AIFEC (Autoinflammation With Infantile Enterocolitis), XIAP Deficiency, CDC42 Mutations
DrugArumakimig
Novartis Pharmaceuticals
Phase 2
17
Ohio, Pennsylvania, Texas, Washington
2020-12-18
Active, closed
Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]
NCT04645212Wet Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration
Adverum Biotechnologies, Inc.
Observational
23
California, Colorado, Florida, Nevada, Pennsylvania, Tennessee, Texas
2020-12-14
Recruiting
A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab
NCT04590326Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Endometrial Cancer
DrugsUbamatamab·Sarilumab·Cemiplimab
Regeneron Pharmaceuticals
Phase 1/2
612
California, Florida, Illinois, Massachusetts, Michigan, New York, Ohio, Pennsylvania
2020-12-08
Recruiting
The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study
NCT04343313Mitral Valve Insufficiency
Half Moon Medical
Not applicable
30
New York, Ohio, Oregon, Pennsylvania
2020-12-08
Active, closed
Triac Trial II in MCT8 Deficiency Patients
NCT02396459Allan-Herndon-Dudley Syndrome
Rare Thyroid Therapeutics International AB
Phase 2
22
Oregon, Pennsylvania
2020-12-07
Active, closed
Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene
NCT04794101X-Linked Retinitis Pigmentosa
MeiraGTx Ocular UK Ltd
Phase 3
97
California, Florida, Georgia, Massachusetts, Michigan, North Carolina, Pennsylvania, Texas
2020-12-04
By invitation
Adherus™ Dural Sealant in Spinal Procedures
NCT04498026Spinal Duraplasty
Stryker Craniomaxillofacial
Not applicable
114
California, Florida, Illinois, Minnesota, New York, North Carolina, Pennsylvania, Texas
2020-11-19
Active, closed
Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)
NCT04408625Frontotemporal Dementia
DrugMethylprednisolone
Prevail Therapeutics
Phase 1/2
35
Florida, Massachusetts, Pennsylvania
2020-11-09
Active, closed
Study to Evaluate the Safety and Efficacy of PF-06939926 for the Treatment of Duchenne Muscular Dystrophy
NCT04281485Duchenne Muscular Dystrophy
Pfizer
Phase 3
114
Arkansas, California, Florida, Iowa, Kansas, North Carolina, Pennsylvania, Utah
2020-11-05
Active, closed
Study of Efficacy and Safety of LXH254 Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma
NCT04417621Melanoma
DrugsNaporafenib·Trametinib·Ribociclib
Novartis Pharmaceuticals
Phase 2
134
California, Florida, Massachusetts, Minnesota, New York, Pennsylvania, Texas
2020-10-30
Active, closed
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
NCT04440189Osteoarthritis, Knee
GID BIO, Inc.
Phase 3
114
California, Florida, Louisiana, New Jersey, North Carolina, Ohio, Pennsylvania, Texas
2020-10-15
Active, closed
Myasthenia Gravis Inebilizumab Trial
NCT04524273Myasthenia Gravis
DrugInebilizumab
Amgen
Phase 3
238
California, Connecticut, District of Columbia, Florida, Kansas, North Carolina, Ohio, Pennsylvania
2020-10-15
Active, closed
CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC
NCT04495153Non Small Cell Lung Cancer
DrugAglatimagene besadenovec
Candel Therapeutics, Inc.
Phase 2
90
Arizona, Connecticut, Illinois, Maryland, Minnesota, New York, Ohio, Pennsylvania
2020-10-13
Active, closed
A Study of DSP107 Alone and in Combination with Atezolizumab for Patients with Advanced Solid Tumors
NCT04440735Advanced Solid Tumor, Non Small Cell Lung Cancer, Colorectal Cancer
DrugsDSP107·Atezolizumab
Kahr Medical
Phase 1/2
125
California, Colorado, Florida, Indiana, Kansas, Pennsylvania
2020-10-07
Active, closed
A Gene Transfer Study for Late-Onset Pompe Disease (RESOLUTE)
NCT04093349Pompe Disease, Pompe Disease (Late-onset), Glycogen Storage Disease Type 2, Glycogen Storage Disease Type II
Spark Therapeutics, Inc.
Phase 1/2
4
Arizona, California, Georgia, Kansas, Minnesota, Oregon, Pennsylvania, Utah
2020-10-01
Recruiting
A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)
NCT04422912Pemphigus Vulgaris
DrugRese-cel
Cabaletta Bio
Phase 1/2
40
California, Connecticut, Illinois, Iowa, Massachusetts, New York, North Carolina, Pennsylvania
2020-09-29
Active, closed
Open Nipple Sparing Mastectomy (NSM)
NCT04447339Nipple Sparing Mastectomy
Intuitive Surgical
Observational
75
Illinois, Minnesota, New York, Pennsylvania, Texas
2020-09-21
Active, closed
A Study of Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma
NCT04557098Hematological Malignancies
DrugTeclistamab
Janssen Research & Development, LLC
Phase 2
194
Alabama, California, Georgia, Michigan, New York, North Carolina, Pennsylvania
2020-09-17
Recruiting
A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
NCT04370587Solid Tumor, Melanoma, HNSCC, Sarcoma
DrugT3011
ImmVira Pharma Co. Ltd
Phase 1/2
30
Arizona, Massachusetts, Pennsylvania, Texas, Virginia
2020-09-17
Active, closed
Adjuvant Chemotherapy in Patients With Intermediate or High Risk Stage I or Stage IIA Non-squamous Non-Small Cell Lung Cancer: AIM-HIGH (Adjuvant Intervention in Molecular High Risk Patients)
NCT01817192Non-Small Cell Lung Cancer
Razor Genomics
Not applicable
420
California, Florida, Kentucky, Missouri, New Jersey, North Carolina, Oklahoma, Pennsylvania
2020-09-11
Active, closed
An Open-label, Phase 1/2 Trial of Gene Therapy 4D-310 in Adults With Fabry Disease
NCT04519749Fabry Disease
Drug4D-310
4D Molecular Therapeutics
Phase 1/2
18
California, Georgia, Pennsylvania, Virginia
2020-09-01
Recruiting
A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)
NCT04419649Myelodysplastic Syndromes, Cytopenia
DrugElritercept
Takeda
Phase 2
160
Arkansas, California, Florida, Maryland, Michigan, New Jersey, New York, Pennsylvania
2020-08-19
Active, closed
A Study to Evaluate MEDI5752 and Axitinib in Subjects With Advanced Renal Cell Carcinoma
NCT04522323Advanced Renal Cell Carcinoma
DrugsVolrustomig·Axitinib·Lenvatinib
MedImmune LLC
Phase 1
67
District of Columbia, Florida, Missouri, New York, Ohio, Pennsylvania, Tennessee
2020-08-05
Active, closed
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib
NCT04421963Ovarian Cancer, Breast Cancer
DrugOlaparib
AstraZeneca
Phase 3
185
Florida, Maryland, Michigan, Minnesota, New Jersey, New York, Pennsylvania, Rhode Island
2020-08-04
Active, closed
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
NCT04449874Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumors
DrugsDivarasib·Erlotinib·Inavolisib·Cetuximab
Genentech, Inc.
Phase 1
498
California, Connecticut, Florida, Massachusetts, New York, Oklahoma, Pennsylvania
2020-07-29
Active, closed
A Study to Test Different Doses of Obrixtamig in Patients With Small Cell Lung Cancer and Other Neuroendocrine Tumours That Are Positive for DLL3
NCT04429087Small Cell Lung Carcinoma and Other Neuroendocrine Neoplasms Expressing DLL3
DrugObrixtamig
Boehringer Ingelheim
Phase 1
306
Georgia, Maryland, Missouri, Pennsylvania
2020-07-29
Active, closed
Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies
NCT04561362Urinary Bladder Neoplasm, Triple Negative Breast Neoplasms, Hormone Receptor Positive, HER2-negative Neoplasms, Hormone Receptor Positive, HER2-low Neoplasms
DrugsZelenectide pevedotin·Keytruda·Pembrolizumab
BicycleTx Limited
Phase 1/2
329
Colorado, Florida, New York, Ohio, Pennsylvania, Tennessee, Texas
2020-07-17
Active, closed
A Study of Tividenofusp Alfa (DNL310) in Pediatric Participants With Hunter Syndrome
NCT04251026Mucopolysaccharidosis II
DrugTividenofusp alfa
Denali Therapeutics Inc.
Phase 1/2
47
California, Illinois, North Carolina, Pennsylvania
2020-07-16
Active, closed
Linerixibat Long-term Safety, and Tolerability Study
NCT04167358Cholestasis
GlaxoSmithKline
Phase 3
242
California, Florida, Michigan, New York, North Carolina, Pennsylvania, Texas, Washington
2020-07-14
Recruiting
An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System
NCT04029337Mitral Regurgitation
HighLife SAS
Not applicable
30
Arizona, California, Georgia, Massachusetts, Minnesota, New York, Pennsylvania, South Carolina
2020-07-14
Active, closed
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:
NCT02616484Pyruvate Dehydrogenase Complex Deficiency
Saol Therapeutics Inc
Phase 3
34
California, District of Columbia, Florida, Ohio, Pennsylvania, Texas, Utah, Washington
2020-07-14
Active, closed
Bilateral Treatment of Medication Refractory Essential Tremor
NCT04112381Essential Tremor
InSightec
Not applicable
51
California, Maryland, New York, Ohio, Pennsylvania, Virginia, West Virginia
2020-06-30
Active, closed
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma
NCT04106219Neuroblastoma
DrugsTopotecan·Cyclophosphamide
Eli Lilly and Company
Phase 1
71
California, Colorado, Illinois, Massachusetts, Ohio, Pennsylvania, Texas
2020-06-11
Recruiting
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
NCT04429542Head and Neck Squamous Cell Carcinoma, Squamous Cell Carcinoma of Anal Canal, Colorectal Cancer, Squamous Cell Carcinoma of the Lung
DrugPembrolizumab
Bicara Therapeutics
Phase 1
292
California, Florida, Massachusetts, New York, North Carolina, Ohio, Pennsylvania, Rhode Island
2020-06-01
Active, closed
2019-06 TRISCEND Study
NCT04221490Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases
Edwards Lifesciences
Not applicable
228
California, Georgia, Illinois, Massachusetts, Michigan, New York, Oregon, Pennsylvania
2020-05-06
Active, closed
Registry of Sarcoma Patients Treated With Permanently Implantable LDR CivaSheet®
NCT04033081Sarcoma
CivaTech Oncology
Phase 4
100
Pennsylvania
2020-04-30
Active, closed
Study to Evaluate the Safety and Tolerability of FX201 in Patients With Osteoarthritis of the Knee
NCT04119687Osteoarthritis, Knee
Pacira Pharmaceuticals, Inc
Phase 1
72
Arizona, Florida, Missouri, Pennsylvania, Texas
2020-03-02
Active, closed
A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma
NCT04108195Multiple Myeloma
DrugsTalquetamab·Darzalex·Teclistamab·Pomalidomide
Janssen Research & Development, LLC
Phase 1
290
California, New York, North Carolina, Pennsylvania, Tennessee, Wisconsin
2020-02-21
Active, closed
ZIP Study-OL Study of Safety, PK, Efficacy, PD, Immunogenicity of ATB200/AT2221 in Pediatrics Aged 0 to < 18 y.o. w/LOPD
NCT03911505Pompe Disease (Late-onset)
DrugsCipaglucosidase alfa·Miglustat
Amicus Therapeutics
Phase 3
21
Florida, Georgia, Missouri, North Carolina, Ohio, Pennsylvania, Utah, Virginia
2020-02-13
Active, closed
Prospective Natural History Study of Retinitis Pigmentosa
NCT04285398Retinitis Pigmentosa
SparingVision
Not applicable
82
Pennsylvania
2020-02-12
Active, closed
DS8201a and Pembrolizumab in Participants With Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer
NCT04042701Breast Cancer, Non-small Cell Lung Carcinoma
DrugsTrastuzumab deruxtecan·Keytruda·Pembrolizumab
Daiichi Sankyo
Phase 1
115
California, Connecticut, Florida, Maryland, Massachusetts, Missouri, Pennsylvania, Texas
2020-02-10
Active, closed
A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer
NCT04077099NSCLC
Regeneron Pharmaceuticals
Phase 1/2
95
California, District of Columbia, Florida, Massachusetts, New York, Pennsylvania, Texas
2020-01-07
Active, closed
Phase 1/2a Clinical Trial of PR001 (LY3884961) in Patients With Parkinson's Disease With at Least One GBA1 Mutation (PROPEL)
NCT04127578Parkinson Disease
DrugsSirolimus·Methylprednisolone
Prevail Therapeutics
Phase 1/2
32
Arizona, California, Colorado, Florida, Illinois, Minnesota, New York, Pennsylvania
2020-01-03
Active, closed
Cusatuzumab in Combination With Background Therapy for the Treatment of Participants With Acute Myeloid Leukemia
NCT04150887Leukemia, Myeloid, Acute
DrugsCusatuzumab·Venclexta·Azacitidine·Venetoclax
OncoVerity, Inc.
Phase 1
61
California, Kentucky, Michigan, New York, Pennsylvania, Texas, Vermont, Wisconsin
2019-12-23
Recruiting
Medtronic Cardiac Surgery PMCF Registry
NCT04073420Valve Disease, Heart
Medtronic Cardiac Surgery
Observational
2,700
Georgia, Michigan, New York, North Carolina, Ohio, Pennsylvania, Texas, Virginia
2019-12-02
Active, closed
Zephyr Valve Registry (ZEVR)
NCT04186546Emphysema
Pulmonx Corporation
Observational
150
Alabama, Illinois, Michigan, Pennsylvania, Texas, Virginia, Wisconsin
2019-11-25
Active, closed
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia Without Inhibitors
NCT04082429Haemophilia A Without Inhibitors, Haemophilia B Without Inhibitors
DrugConcizumab
Novo Nordisk A/S
Phase 3
156
California, Georgia, Indiana, Iowa, Michigan, North Carolina, Pennsylvania, Tennessee
2019-11-13
Active, closed
A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm
NCT04041050Myeloproliferative Neoplasm
DrugsNavitoclax·Celebrex·Celecoxib·Ruxolitinib
AbbVie
Phase 1
85
California, Illinois, Kentucky, Michigan, Nebraska, North Carolina, Ohio, Pennsylvania
2019-11-08
Active, closed
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
NCT04180371Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer, Ovarian Cancer, Non-small Cell Lung Cancer
DrugsNuzefatide pevedotin·Opdivo·Nivolumab
BicycleTx Limited
Phase 1/2
288
California, Colorado, Florida, Michigan, Nevada, New York, Oklahoma, Pennsylvania
2019-11-07
Recruiting
HeartStart FRx Defibrillator Event Registry
NCT04250857Sudden Cardiac Arrest
Heartstream US LLC
Observational
1,400
Pennsylvania
2019-11-04
Active, closed
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.
NCT04157348Eosinophilic Granulomatous Vasculitis
DrugsBenralizumab·Mepolizumab
AstraZeneca
Phase 3
140
Colorado, Michigan, Minnesota, New Mexico, New York, Pennsylvania, Texas, Washington
2019-10-29
Active, closed
Study of Subretinally Injected ATSN-101 Administered in Patients With Leber Congenital Amaurosis Caused by Biallelic Mutations in GUCY2D
NCT03920007Leber Congenital Amaurosis, LCA, LCA1
DrugsPrednisolone·Prednisone
Atsena Therapeutics Inc.
Phase 1/2
15
Oregon, Pennsylvania
2019-10-22
Active, closed
Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and With Pembrolizumab
NCT04130516Solid Tumor, Adult
DrugsKeytruda·Pembrolizumab
Linnaeus Therapeutics, Inc.
Phase 1/2
200
California, Connecticut, Massachusetts, New Mexico, New York, Pennsylvania, Texas
2019-10-21
Recruiting
Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)
NCT04150497B-cell Acute Lymphoblastic Leukemia
DrugAlemtuzumab
Cellectis S.A.
Phase 1/2
52
California, Colorado, Illinois, Massachusetts, New York, Pennsylvania, Tennessee, Texas
2019-10-14
Active, closed
Alfapump® System in the Treatment of Refractory or Recurrent Ascites (POSEIDON Study)
NCT03973866Ascites
Sequana Medical N.V.
Not applicable
110
Arizona, California, Massachusetts, Minnesota, North Carolina, Pennsylvania, South Carolina, South Dakota
2019-09-16
Active, closed
A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer
NCT04077463Carcinoma, Non-Small-Cell Lung
DrugsLazertinib·Amivantamab·Pemetrexed·Carboplatin
Janssen Research & Development, LLC
Phase 1
701
California, Florida, Massachusetts, Michigan, Missouri, New York, Oregon, Pennsylvania
2019-09-04
Active, closed
Study of Photobiomodulation to Treat Dry Age-Related Macular Degeneration (LIGHTSITE III)
NCT04065490Dry Age-related Macular Degeneration
LumiThera, Inc.
Not applicable
96
California, Florida, Maryland, New Jersey, New York, North Carolina, Pennsylvania, Texas
2019-09-01
Recruiting
Intravesical Photodynamic Therapy ("PDT") in BCG-Unresponsive/Intolerant Non-Muscle Invasive Bladder Cancer ("NMIBC") Patients
NCT03945162Non-Muscle Invasive Bladder Cancer ("NMIBC") Unresponsive/Intolerant to BCG
Theralase® Technologies Inc.
Phase 2
90
Illinois, Indiana, New York, Ohio, Pennsylvania, South Carolina, Tennessee, Texas
2019-08-30
Active, closed
A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation
NCT04002297Mantle Cell Lymphoma; Non-Hodgkin Lymphoma
DrugsBendamustine·Zanubrutinib·Rituximab
BeOne Medicines
Phase 3
510
California, Illinois, Massachusetts, Michigan, Nevada, New York, Oregon, Pennsylvania
2019-08-20
Recruiting
A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials
NCT04064060Myelodysplastic Syndromes (MDS), Beta-thalassemia, Myeloproliferative Neoplasm(MPN)-Associated Myelofibrosis
DrugLuspatercept
Celgene
Phase 3
665
California, Florida, Illinois, Massachusetts, Michigan, New York, Ohio, Pennsylvania
2019-08-12
Active, closed
A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis
NCT04035005Multiple Sclerosis, Primary Progressive
DrugOcrelizumab
Hoffmann-La Roche
Phase 3
1,013
District of Columbia, Florida, Kansas, Ohio, Pennsylvania
2019-08-12
Recruiting
Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies
NCT04068597Haematological Malignancy, Acute Myeloid Leukemia, Non Hodgkin Lymphoma, Multiple Myeloma
DrugsIxazomib·Elranatamab·Teclistamab·Pomalidomide
CellCentric Ltd.
Phase 1/2
250
Georgia, Indiana, Maryland, Nebraska, Pennsylvania
2019-08-09
Active, closed
A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)
NCT04008030Metastatic Colorectal Cancer
DrugsFluorouracil·Leucovorin·Ipilimumab·Cetuximab
Bristol-Myers Squibb
Phase 3
839
California, Colorado, Illinois, New York, Oregon, Pennsylvania, Texas, Virginia
2019-08-05
Active, closed
Omega3 Wound Fish Skin Graft in the Treatment of DFUs
NCT04133493Diabetic Foot Ulcer
Kerecis Ltd.
Not applicable
100
Florida, Georgia, Indiana, Ohio, Pennsylvania
2019-07-31
Active, closed
A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B
NCT03861273Hemophilia B
Pfizer
Phase 3
51
California, Colorado, Indiana, Mississippi, Pennsylvania
2019-07-29
Active, closed
Cancer Stem Cell Assay Directed Chemotherapy in Recurrent Platinum Resistant Ovarian Cancer
NCT03949283Recurrent Ovarian Carcinoma, Platinum-resistant Ovarian Cancer
Cordgenics, LLC
Phase 3
150
California, Florida, Louisiana, Ohio, Oklahoma, Pennsylvania, West Virginia
2019-07-26
Recruiting
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
NCT03947385Metastatic Uveal Melanoma, Cutaneous Melanoma, Colorectal Cancer, Other Solid Tumors
DrugsDarovasertib·Binimetinib·Crizotinib
IDEAYA Biosciences
Phase 1/2
336
California, Colorado, Iowa, Michigan, New York, North Carolina, Ohio, Pennsylvania
2019-06-28
Active, closed
Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, r/r ALL and 1L HR LBCL
NCT03960840Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Diffuse Large B-cell Lymphoma, Acute Lymphoblastic Leukemia
DrugIbrutinib
Novartis Pharmaceuticals
Phase 1/2
217
California, Florida, Illinois, Kansas, Massachusetts, Pennsylvania, Tennessee, Texas
2019-06-26
Active, closed
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Upadacitinib in Pediatric Subjects With Polyarticular Course Juvenile Idiopathic Arthritis
NCT03725007Juvenile Idiopathic Arthritis (JIA)
DrugUpadacitinib
AbbVie
Phase 1
124
Illinois, Kentucky, Massachusetts, Ohio, Oregon, Pennsylvania, Washington
2019-06-24
Active, closed
A Study of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Participants With Advanced Kidney Cancer
NCT03873402Renal Cell Carcinoma
DrugsYervoy·Ipilimumab·Opdivo·Nivolumab
Bristol-Myers Squibb
Phase 3
437
District of Columbia, Georgia, Massachusetts, Pennsylvania, South Carolina
2019-06-21
Recruiting
Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer
NCT03659448Colorectal Neoplasms
Surgimab
Phase 3
300
California, Florida, Massachusetts, Pennsylvania
2019-06-17
Active, closed
A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors
NCT03899792Medullary Thyroid Cancer, Infantile Myofibromatosis, Infantile Fibrosarcoma, Papillary Thyroid Cancer
DrugSelpercatinib
Eli Lilly and Company
Phase 1/2
36
California, Colorado, Florida, Massachusetts, Minnesota, New York, Ohio, Pennsylvania
2019-06-13
By invitation
Long-term Follow-Up Study of RGX-314 and Fellow Eye Substudy
NCT03999801Neovascular Age-related Macular Degeneration, Wet Macular Degeneration
AbbVie
Phase 2
865
Arizona, California, Maryland, Massachusetts, Nevada, Pennsylvania, Tennessee, Texas
2019-05-31
Active, closed
Case-Control Study of the Glycotest™ HCC Panel vs AFP for the Detection of Early-stage Hepatocellular Carcinoma
NCT03878550Carcinoma, Hepatocellular, Cirrhosis, Liver
Glycotest, Inc.
Observational
766
California, Florida, Illinois, Maryland, Michigan, Minnesota, New York, Pennsylvania
2019-05-22
Active, closed
A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors
NCT03893955Cancer, Advanced Solid Tumors, Triple-Negative Breast Cancer (TNBC), Non-small-cell-lung-cancer (NSCLC)
DrugsABBV-927·Budigalimab·Nab-paclitaxel·Carboplatin
AbbVie
Phase 1
150
Arkansas, California, Connecticut, Florida, Indiana, Missouri, North Carolina, Pennsylvania
2019-05-21
Recruiting
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
NCT03686124Refractory Cancer, Recurrent Cancer, Solid Tumor, Adult, Cancer
DrugsAnzu-cel·Opdivo·Nivolumab
Immatics US, Inc.
Phase 1/2
375
California, Colorado, Florida, Illinois, Massachusetts, New York, Ohio, Pennsylvania
2019-05-14
Active, closed
ASP-1929 Photoimmunotherapy (PIT) Study in Recurrent Head/Neck Cancer for Patients Who Have Failed at Least Two Lines of Therapy
NCT03769506Head and Neck Cancer
Rakuten Medical, Inc.
Phase 3
135
Florida, Georgia, Kentucky, Pennsylvania, Texas
2019-05-09
Active, closed
A Dose Escalation Study Evaluating CPI-818 in Relapsed/Refractory T-Cell Lymphoma
NCT03952078T-cell Lymphoma
DrugSoquelitinib
Corvus Pharmaceuticals, Inc.
Phase 1
151
California, Michigan, Missouri, New Jersey, Ohio, Pennsylvania
2019-05-03
Recruiting
A Trial of Etelcalcetide in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis
NCT03633708Secondary Hyperparathyroidism, Chronic Kidney Disease
DrugEtelcalcetide
Amgen
Phase 3
56
California, Colorado, Missouri, New York, Ohio, Oklahoma, Pennsylvania, Texas
2019-04-29
Active, closed
Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer
NCT03907852Mesothelioma, Mesothelioma, Malignant, Mesothelioma; Pleura, Mesotheliomas Pleural
DrugsIpilimumab·Fludarabine·Nivolumab·Cyclophosphamide
TCR2 Therapeutics
Phase 1/2
57
California, Florida, Illinois, Maryland, New York, North Carolina, Pennsylvania, Tennessee
2019-04-15
Active, closed
A Registry of Subjects With Primary Indeterminate Lesions or Choroidal Melanoma
NCT03941379Choroidal Melanoma, Indeterminate Lesions of Eye
Aura Biosciences
Observational
63
Arizona, California, Massachusetts, Michigan, Minnesota, New York, Oregon, Pennsylvania
2019-03-27
Recruiting
Reduction of Adverse Drug Events and Readmissions
NCT02738047Pharmacogenomic Testing for Medication Management
ClinLogic LLC
Observational
280,000
Pennsylvania
2019-03-15
Recruiting
Deep Brain Stimulation (DBS) Retrospective Outcomes Study
NCT03664609Parkinson Disease, Essential Tremor, Dystonia
Boston Scientific Corporation
Observational
5,000
Arizona, California, Florida, Idaho, New York, North Carolina, Pennsylvania, Washington
2019-03-12
Active, closed
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
NCT03768063Cancer
DrugsEmactuzumab·Rucaparib·Cobimetinib·Vemurafenib
Hoffmann-La Roche
Phase 3
1,000
Colorado, Connecticut, Massachusetts, North Carolina, Pennsylvania, Texas
2019-02-28
Recruiting
Two Dose Levels of Privigen in Pediatric CIDP
NCT03684018Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
DrugImmunoglobulins
CSL Behring
Phase 4
30
Arizona, California, Iowa, Ohio, Pennsylvania, Tennessee, Texas, Virginia
2019-02-28
Active, closed
Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa
NCT03827798Hidradenitis Suppurativa
DrugsArumakimig·Ianalumab·Remibrutinib
Novartis Pharmaceuticals
Phase 2
248
Florida, Georgia, Illinois, Indiana, Pennsylvania, South Carolina
2019-02-27
Active, closed
The CONFORMAL Early Feasibility Study
NCT03616028Non-valvular Atrial Fibrillation
Conformal Medical, Inc
Not applicable
64
Arkansas, California, New Hampshire, New York, Ohio, Pennsylvania, Tennessee, Texas
2019-02-22
Recruiting
A Trial to Evaluate Safety, Tolerability, and Preliminary Efficacy of Misetionamide (GP-2250) as Monotherapy or in Combination With Gemcitabine
NCT03854110Ovarian Cancer
DrugGemcitabine
Persevere Therapeutics Inc.
Phase 1
80
Illinois, Kansas, Massachusetts, Pennsylvania
2019-01-14
Active, closed
Osimertinib Plus Savolitinib in EGFRm+/MET+ NSCLC Following Prior Osimertinib
NCT03778229Carcinoma
DrugsSavolitinib·Osimertinib
AstraZeneca
Phase 2
367
California, District of Columbia, Maryland, Massachusetts, Minnesota, New York, Pennsylvania, Washington
2019-01-09
Active, closed
A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC
NCT03819465Metastatic Non-Small Cell Lung Cancer (NSCLC)
DrugsDanvatirsen·Oleclumab·Volrustomig·Rilvegostomig
AstraZeneca
Phase 1
175
Iowa, Pennsylvania, Tennessee
2018-12-27
Active, closed
Study of Durvalumab+Olaparib or Durvalumab After Treatment With Durvalumab and Chemotherapy in Patients With Lung Cancer (ORION)
NCT03775486Non-small Cell Lung Cancer NSCLC
DrugsOlaparib·Durvalumab·Nab-paclitaxel·Pemetrexed
AstraZeneca
Phase 2
401
Florida, Missouri, Pennsylvania, Tennessee, Texas
2018-12-21
Active, closed
A Study to Evaluate the Long-term Safety and Tolerability of Lucerastat in Adult Subjects With Fabry Disease
NCT03737214Fabry Disease
Idorsia Pharmaceuticals Ltd.
Phase 3
107
Alabama, California, Florida, Illinois, Iowa, Massachusetts, Michigan, Pennsylvania
2018-12-18
Active, closed
Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC
NCT03562637Triple Negative Breast Cancer
OBI Pharma, Inc
Phase 3
575
California, Florida, Illinois, Maryland, Michigan, New Jersey, Pennsylvania, Texas
2018-12-05
Recruiting
Medtronic Terminate AF Study
NCT03546374Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Medtronic Cardiac Surgery
Not applicable
160
California, Connecticut, Indiana, Massachusetts, Michigan, Missouri, Ohio, Pennsylvania
2018-11-15
Active, closed
Early Weight-Bearing After the Lapiplasty Procedure
NCT03740282Hallux Valgus, Bunion
Treace Medical Concepts, Inc.
Not applicable
183
Colorado, Iowa, Missouri, Nevada, Pennsylvania, Texas
2018-11-06
Active, closed
Long-Term Follow-Up Study for Subjects Treated With P-BCMA-101
NCT03741127Multiple Myeloma
Poseida Therapeutics, Inc.
Phase 1
100
California, Colorado, Illinois, Kansas, Maryland, Michigan, Pennsylvania, Tennessee
2018-10-29
Recruiting
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
NCT03588975Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee
Vericel Corporation
Phase 3
45
California, Louisiana, Maryland, Michigan, New York, Ohio, Pennsylvania, Texas
2018-10-24
Active, closed
Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer.
NCT03616587ER+ HER2- Advanced Breast Cancer
DrugCamizestrant
AstraZeneca
Phase 1
396
Colorado, Florida, Pennsylvania, Tennessee, Utah
2018-10-11
By invitation
The Influence of Repairing the Sub-scapularis on Outcomes After Reverse Arthroplasty
NCT03711175Severe Arthropathy With a Grossly Deficient Rotator Cuff
Encore Medical, L.P.
Not applicable
200
Missouri, New York, Pennsylvania, Texas
2018-09-28
Active, closed
CAMPSIITE™ RGX-121 Gene Therapy in Subjects With MPS II (Hunter Syndrome)
NCT03566043Mucopolysaccharidosis Type II (MPS II)
REGENXBIO Inc.
Phase 2/3
48
California, New Jersey, Pennsylvania
2018-09-27
Active, closed
Dose-escalation Study to Evaluate the Safety and Tolerability of GS030 in Subjects With Retinitis Pigmentosa
NCT03326336Non-syndromic Retinitis Pigmentosa
GenSight Biologics
Phase 1/2
10
Pennsylvania
2018-09-26
Active, closed
A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma
NCT03671018B-cell Non-Hodgkin Lymphoma
DrugsMosunetuzumab·Polatuzumab Vedotin·Tocilizumab·Rituximab
Hoffmann-La Roche
Phase 1/2
422
Alabama, California, Colorado, Florida, Michigan, New York, North Carolina, Pennsylvania
2018-09-25
Active, closed
Study of Abexinostat in Patients With Relapsed or Refractory Follicular Lymphoma
NCT03600441Follicular Lymphoma
DrugAbexinostat
Xynomic Pharmaceuticals, Inc.
Phase 2
139
Illinois, Kentucky, New York, Pennsylvania, Texas, Washington
2018-08-27
Active, closed
A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer
NCT03456076Carcinoma, Non-Small-Cell Lung
DrugsAlectinib·Vinorelbine·Pemetrexed·Gemcitabine
Hoffmann-La Roche
Phase 3
257
Illinois, Massachusetts, Pennsylvania
2018-08-16
Active, closed
Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood
NCT03793478Acute Myeloid Leukemia
DrugsQuizartinib·Cytarabine·Etoposide·Fludarabine
Daiichi Sankyo
Phase 1/2
65
California, Colorado, Delaware, District of Columbia, Georgia, Minnesota, Ohio, Pennsylvania
2018-08-15
Active, closed
Long-Term Safety and Efficacy of Spark-Sponsored Gene Therapies in Males With Hemophilia A
NCT03432520Hemophilia A
Spark Therapeutics, Inc.
Observational
29
Massachusetts, Mississippi, Missouri, Oregon, Pennsylvania, Virginia
2018-08-14
Active, closed
Long Term Extension of Safety and Efficacy of Vagus Nerve Stimulator in Patients With Rheumatoid Arthritis (RA)
NCT04862117Rheumatoid Arthritis
SetPoint Medical Corporation
Not applicable
14
Florida, New York, Pennsylvania
2018-07-28
Active, closed
Clinical Study of Edwards Cardioband FIT Valve Repair System
NCT03382457Tricuspid Regurgitation
Edwards Lifesciences
Not applicable
75
Illinois, Minnesota, New Jersey, New York, Oregon, Pennsylvania, Texas, Utah
2018-07-01
Active, closed
LTFU Study of Subjects With Cervical SCI Who Received AST-OPC1
NCT05975424Spinal Cord Injuries
Lineage Cell Therapeutics, Inc.
Observational
25
California, Georgia, Illinois, Pennsylvania, Wisconsin
2018-06-13
Active, closed
A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)
NCT03401788VHL - Von Hippel-Lindau Syndrome, VHL Gene Mutation, VHL Syndrome, VHL Gene Inactivation
DrugBelzutifan
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 2
50
Maryland, Massachusetts, Michigan, Pennsylvania, Tennessee, Texas, Utah
2018-05-02
Active, closed
Pyruvate Kinase Deficiency Global Longitudinal Registry
NCT03481738Pyruvate Kinase Deficiency
Agios Pharmaceuticals, Inc.
Observational
500
Arizona, Arkansas, California, Georgia, Massachusetts, Michigan, North Carolina, Pennsylvania
2018-04-23
By invitation
Adoptive Cell Therapy Long-term Follow-up (LTFU) Study
NCT03391778Neoplasms
USWM CT, LLC
Phase 1
250
Georgia, Maryland, Michigan, Missouri, New York, North Carolina, Oregon, Pennsylvania
2018-04-09
Active, closed
A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer
NCT03473743Urothelial Carcinoma
DrugsErdafitinib·Cetrelimab·Cisplatin·Carboplatin
Janssen Research & Development, LLC
Phase 1/2
125
Colorado, Kentucky, Maryland, New Jersey, New York, North Carolina, Ohio, Pennsylvania
2018-04-05
Active, closed
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
NCT03423628Recurrent Glioblastoma Multiforme, Primary Glioblastoma Multiforme, Brain Neoplasms, Malignant, Leptomeningeal Disease (LMD)
DrugAZD1390
AstraZeneca
Phase 1
159
Massachusetts, New York, Pennsylvania, Virginia
2018-04-02
Active, closed
A Study of Durvalumab Alone and Durvalumab+Olaparib in Advanced, Platinum-Ineligible Bladder Cancer (BAYOU)
NCT03459846Urinary Bladder Neoplasms
DrugsOlaparib·Durvalumab
AstraZeneca
Phase 2
154
Alabama, Arizona, Florida, Kentucky, New York, Pennsylvania, Tennessee, Washington
2018-03-16
Active, closed
A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer
NCT03431350Prostatic Neoplasms, Castration-Resistant
DrugsCetrelimab·Abiraterone acetate·Niraparib·Prednisone
Janssen Research & Development, LLC
Phase 2
136
Arizona, Colorado, Florida, Indiana, Maryland, Michigan, New York, Pennsylvania
2018-03-02
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Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 6 October 2026. https://priyalifescience.com/clinical-trials-usa/state/pennsylvania?page=2

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,118 studies in total at the last sync on 06 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,048 of those studies with a site in Pennsylvania.

How many clinical trials are recruiting in Pennsylvania?

580 of the 1,048 studies on this page are recruiting new participants as of the 06 Oct 2026, 03:16 UTC sync. A further 37 have not yet opened recruitment, 392 are active but closed to new participants, and 39 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.