AVZO-021 clinical trials
AVZO-021 is named as an intervention in 2 current clinical trials in our USA and Australia registers. 2 are recruiting patients now. All registered phases are Phase 1/2. The lead sponsor is Avenzo Therapeutics, Inc. The most-studied condition is HR+/HER2- Breast Cancer. The EU clinical trials register (CTIS) separately lists 1 authorised or ongoing trial.
Patient leaflets for AVZO-021
The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.
- UKUnited Kingdom: Search MHRA ProductsPatient information leaflets and SmPCs for UK-licensed products.
- USUnited States: Search DailyMedFDA-approved labels, including patient and medication guides.
Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.
Trials by status
Trials by phase
Clinical trials of AVZO-021
2 trials| Study | Phase | Status | Lead sponsor | Registers |
|---|---|---|---|---|
|
Study of AVZO-021 in Patients With Advanced Solid Tumors
NCT05867251 · Advanced Solid Tumor, HR+/HER2- Breast Cancer, HR+, HER2-, Advanced Breast Cancer
|
Phase 1/2 | Recruiting | Avenzo Therapeutics, Inc | USA, Australia |
|
ORION-1: Study of AVZO-023 as a Single Agent and in Combination With AVZO-021, and/or Endocrine Therapy in Advanced Solid Tumors
NCT06998407 · HR+/HER2- Breast Cancer, HR+, HER2-, Advanced Breast Cancer
|
Phase 1/2 | Recruiting | Avenzo Therapeutics, Inc | USA |
Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
AVZO-021 in the EU trials register (CTIS)
1 trialAuthorised or ongoing trials in the EU Clinical Trials Information System that list a product containing AVZO-021. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.
| Study | Phase | Status | Sponsor | Countries |
|---|---|---|---|---|
|
ORION-1: A phase 1/2, first-in-human study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of AVZO-023 as a single agent, and in combination with AVZO-021 and/or endocrine therapy in patients with advanced solid tumors
2026-525948-15-00 · CTIS ↗ · Neoplasms
|
Phase 1 | Authorised | Avenzo Therapeutics Inc | Spain, France, Germany + 1 more |
Conditions studied with AVZO-021
4 conditionsSponsors
lead sponsor per trial| Lead sponsor | Trials |
|---|---|
| Avenzo Therapeutics, Inc | 2 |
By country register
| Register | Trials | Recruiting |
|---|---|---|
| Clinical trials in USA | 2 | 2 |
| Clinical trials in Australia | 1 | 1 |
| EU register (CTIS) | 1 | — |
A trial with sites in more than one country appears in each of those registers. CTIS does not publish a recruiting flag; its trials may also appear in the registers above.
Related compounds
Questions about AVZO-021 trials
How many clinical trials are testing AVZO-021?
2 current trials in our USA and Australia registers name AVZO-021 as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.
Are AVZO-021 trials recruiting patients?
Yes. 2 of the 2 trials are recruiting: 2 with sites in USA and 1 with sites in Australia. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Who sponsors AVZO-021 clinical trials?
The lead sponsor is Avenzo Therapeutics, Inc. The number in brackets is how many trials each organisation leads.
Where does this information come from?
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how AVZO-021 works or whether it is effective, and it is not medical advice.
How this page is built
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how AVZO-021 works or whether it is effective. Each trial links to its own record so you can check it yourself.
- ClinicalTrials.gov (U.S. National Library of Medicine) ↗ Trial IDs, titles, intervention names and synonyms, phase, overall status, lead sponsor and conditions for every trial on this page
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists AVZO-021 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.