A Study of JNJ-87704916, as Monotherapy and in Combination for Advanced Solid Tumors
Condition(s) studied
Investigational drug(s) / intervention(s)
JNJ-87704916: JNJ-87704916 will be administered as an intratumoral injection.
Cetrelimab: Cetrelimab will be administered.
Standard of Care PD(L)-1: Frontline anti-PD(L)-1 antibody therapy will be administered as standard of care treatment.
Study summary
The purpose of this study is to determine the safety, feasibility, recommended dose(s) and regimen(s) of JNJ-87704916 as monotherapy and in combination with cetrelimab.
Eligibility
Primary outcome measure(s)
- Part 1: Number of Participants with Dose-Limiting Toxicity (DLT) — Up to 5 years
The DLTs are specific adverse events with defined non-hematological toxicities or hematologic toxicities as per the study protocol. - Number of Participants with Adverse Events (AEs) by Severity — From first dose up to 100 days after last dose of study treatment (up to 5 years)
An adverse event is any untoward medical occurrence in a clinical study participant administered a pharmaceutical (investigational or non-investigational) product. An adverse event does not necessarily have a causal relationship with the treatment. Severity will be graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 5.0. Severity scale ranges from Grade 1: mild, Grade 2: moderate, Grade 3: severe, Grade 4: life-threatening, and Grade 5: death related to adverse event.
Trial sites (10)
| Facility | City | Region | Status |
|---|---|---|---|
| NYU Langone Health | New York | New York | Recruiting |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | Suspended |
| UPMC Cancer Centers | Pittsburgh | Pennsylvania | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | Recruiting |
| Toronto General Hospital | Toronto | Ontario | Recruiting |
| Centre Hospitalier de l'Universite de Montreal | Montreal | Quebec | Recruiting |
| Gustave Roussy | Villejuif | France | Recruiting |
| Hosp Univ Vall D Hebron | Barcelona | Spain | Recruiting |
| Hosp Univ Fund Jimenez Diaz | Madrid | Spain | Recruiting |
| Hosp Univ Hm Sanchinarro | Madrid | Spain | Recruiting |
More Johnson & Johnson Enterprise Innovation Inc. trials in the USA
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06311578 on ClinicalTrials.gov ↗ ← All trials in the USA