Clinical trial register · Spain

Clinical Trials in Valencia, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Spain and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

Download CSV

Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 5875 matching records held by the registry are in this view. Synced 11 Oct 2026, 03:18 UTC

5875

Studies in scope

all four open statuses

3096

Recruiting now

open to new participants

1137

Lead sponsors

across recruiting studies

Top sites

Barcelona 3238 Madrid 3046 Valencia 1215 Seville 1054 Málaga 746

Trials with a site in Valencia

Status

Study

Lead sponsor

Phase

Enrol

Sites in Spain

Start

Not yet open

An Open-Label Study to Evaluate the Long-Term Safety and Efficacy of ALXN2220 in Adults With Transthyretin Amyloid Cardiomyopathy

NCT07789483Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

DrugCliramitug

Alexion Pharmaceuticals, Inc.

Phase 3

1,180

Jaén, Málaga, Palma de Mallorca, Salamanca, Barcelona, L'Hospitalet de Llobregat, Valencia, A Coruña

2027-11-23

Not yet open

EmpowerHer: Hybrid Digital Intervention for Breast Cancer Survivors

NCT07676591Breast Cancer, Cancer Survivors, Quality of Life, Exercise Therapy

University of Valencia

Not applicable

147

Valencia

2027-07-01

Not yet open

Lattice vs Pentaspline Comparative Evaluation in Persistent AF

NCT07815171Persistent Atrial Fibrillation

Mitera Hospital

Not applicable

250

Madrid, Valencia

2027-03

Not yet open

Efficacy of "DBT-LIVE", an Identity Skills Training Program, for Borderline Personality Disorder.

NCT07684872Treatment 1:Dialectical Behavior Therapy (DBT), Treatment as Usual

Universidad Europea de Valencia

Not applicable

112

Valencia

2027-01-01

Not yet open

Multimodal Conservative Intervention Versus Surgery for Chronic Refractory Plantar Fasciopathy

NCT07654660Chronic Refractory Plantar Fasciopathy

Universidad Europea de Valencia

Not applicable

120

Valencia

2026-12

Not yet open

Safety and Efficacy Comparison Between CHF5993 100/6 12.5µg pMDI to Seretide Evohaler 125/25µg pMDI in Adolescent Subjects With Asthma

NCT07858123Asthma

Chiesi Farmaceutici S.p.A.

Phase 3

700

Badalona, Barcelona, Cartagena, Jerez de la Frontera, Madrid, Santiago de Compostela, Valencia

2026-11-16

Not yet open

A Study to Understand How Nerandomilast Works in People With Active Idiopathic Inflammatory Myopathies

NCT07789015Idiopathic Inflammatory Myopathies

DrugNerandomilast

Boehringer Ingelheim

Phase 3

270

Barcelona, Madrid, Málaga, Valencia

2026-11-09

Not yet open

Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Inebilizumab in Pediatric Participants With IgG4-RD

NCT07222553Immunoglobulin G4-related Disease

DrugInebilizumab

Amgen

Phase 2

Valencia

2026-10-31

Not yet open

Inotuzumab as Post-Trasplantation Therapy for Adult High-risk B-cell Precursor Acute Lymphoblastic Leukemia

NCT07862946Acute Lymphobkastic Leukemia, Adult

DrugInotuzumab Ozogamicin

PETHEMA Foundation

Phase 2

Seville, Valencia, Badalona, Barcelona, Madrid, Málaga, Salamanca, San Sebastián

2026-10-30

Not yet open

A Study to Test Different Doses of BI 3968621 When Given Alone or With Ezabenlimab in Patients With Advanced Cancer

NCT07851103Advanced Solid Tumour

DrugEzabenlimab

Boehringer Ingelheim

Phase 1

Barcelona, Valencia

2026-10-26

Not yet open

ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease

NCT07850063Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease

Boehringer Ingelheim

Phase 3

600

Valencia

2026-10-23

Not yet open

DAREON®-36: A Study to Test Obrixtamig in Combination With ZL-1310 in People With Advanced Small Cell Lung Cancer or Other Neuroendocrine Cancers

NCT07707895Small Cell Lung Cancer, Large Cell Neuroendocrine Lung Carcinoma, Extrapulmonary Neuroendocrine Carcinoma of Small Cell Histology, Extrapulmonary Neuroendocrine Carcinoma of Large Cell Histology

DrugsZL-1310·Obrixtamig·Atezolizumab

Boehringer Ingelheim

Phase 1/2

L'Hospitalet Del Llobregat, Madrid, Valencia

2026-10-19

Not yet open

A Research Study Investigating Denecimig (Mim8) in Adults With Acquired Haemophilia A

NCT07830732Haemophilia A

Novo Nordisk A/S

Phase 3

El Palmar, Barcelona, Madrid, Seville, Valencia

2026-10-09

Not yet open

A Study to Test Obrixtamig in Combination With Pumitamig in People With Advanced Small Cell Lung Cancer (Dareon®-Rosetta35)

NCT07843940Extensive-stage Small Cell Lung Carcinoma, Advanced Small Cell Lung Cancer

DrugsObrixtamig·Pumitamig·Etoposide·Carboplatin

Boehringer Ingelheim

Phase 1/2

Barcelona, Madrid, Valencia

2026-10-05

Not yet open

Contribution of a* to Dental Bleaching After Combined Dental Bleaching

NCT07560761Healthy

University of Valencia

Not applicable

Valencia

2026-10-01

Not yet open

Intervention to Reduce Unwanted Loneliness in Family Caregivers of People With Alzheimer

NCT07639645Alzheimer Disease (AD), Unwanted Loneliness, Family Caregivers, Living With Process

University of Valencia

Not applicable

Valencia

2026-10

Recruiting

A Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency.

NCT07559175Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF), Pancreatic Enzyme Abnormality, Pancreatic Diseases

DrugZenpep

Aimmune Nestlé Health Science US R&D, LLC

Phase 2

Madrid, Murcia, Lleida, Málaga, Valencia

2026-10

Recruiting

neoAGORA: Exploring Clinical Utility of Serial Liquid Biopsy (ctDNA) in Patients With Early-Stage Breast Cancer

NCT07718841Early Breast Cancer (EBC)

Spanish Breast Cancer Research Group

Observational

300

San Sebastián, Barcelona, Madrid, Málaga, Seville, Toledo, Valencia

2026-09-30

Recruiting

A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma

NCT07768189Oropharyngeal Carcinoma (OPC)

DrugsCRB-701·Cetuximab·Docetaxel

Corbus Pharmaceuticals Inc.

Phase 3

260

Barcelona, Madrid, Girona, Seville, Valencia, Zaragoza

2026-09-29

Recruiting

A Study to Test How Well Different Doses of BI 3822971 Are Tolerated by People With Advanced Cancer (Solid Tumours)

NCT07744152Solid Tumours

Boehringer Ingelheim

Phase 1

137

Barcelona, Madrid, Navarra, Valencia

2026-09-21

Recruiting

A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum

NCT07811193Colorectal Adenocarcinoma

DrugsVVD-133214·Pembrolizumab

Vividion Therapeutics, Inc.

Phase 2

140

Santiago de Compostela, Barcelona, Madrid, Málaga, Valencia

2026-09-11

Recruiting

A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib

NCT07623161Myelofibrosis, Anemia

DrugElritercept

Takeda

Phase 3

324

Badalona, L'Hospitalet de Llobregat, Las Palmas de Gran Canaria, Málaga, Barcelona, Madrid, Salamanca, Valencia

2026-09-10

Recruiting

A Study of Ramantamig Plus Daratumumab Versus Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (DVRd) or Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With NDMM For Whom Stem Cell Transplant is Not Planned

NCT07665450Multiple Myeloma

DrugsRamantamig·Bortezomib·Daratumumab·Lenalidomide

Janssen Research & Development, LLC

Phase 3

1,000

Madrid, Valencia

2026-09-09

Recruiting

Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)

NCT07680790Non-Small Cell Lung Cancer

DrugsIza-bren·Osimertinib·Pemetrexed·Cisplatin

Bristol-Myers Squibb

Phase 3

850

Majadahonda, Seville, A Coruña, Jaén, Jerez de la Frontera, Madrid, Málaga, Valencia

2026-09-08

Not yet open

Paclitaxel, Ramucirumab and Tislelizumab Switch Maintenance in Advanced HER2-negative and PD-L1 TAP Score of 5 or More Advanced Gastroesophageal Adenocarcinoma

NCT07763171Gastroesophageal Adenocarcinoma

DrugsRamucirumab·Folfox·Tislelizumab·Paclitaxel

Gruppo Oncologico del Nord-Ovest

Phase 3

244

Barcelona, Madrid, Málaga, Ourense, Pamplona, Santander, Valencia, Zaragoza

2026-09-01

Not yet open

Video-Based Lifestyle Counseling in Adults With Type 2 Diabetes.

NCT07557264Diabetes Mellitus (Type 2), Glycemic Control for Diabetes Mellitus, Physical Activity, Healthy Eating

Cardenal Herrera University

Not applicable

156

Valencia

2026-09-01

Not yet open

Exercise-Based Cardiac Rehabilitation for Patients With Heart Failure With Preserved Ejection Fraction (EMPOWER-HFpEF)

NCT07727096HF - Heart Failure, HFpEF - Heart Failure With Preserved Ejection Fraction, Readmission Rates, Exercise Training

Fundación para la Investigación del Hospital Clínico de Valencia

Not applicable

390

Valencia

2026-09-01

Recruiting

A Phase III Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With CKD Stage 3b and 4 (BalanceD-CKD)

NCT07624305Renal Insufficiency, Chronic

DrugsBalcinrenone/dapagliflozin·Dapagliflozin

AstraZeneca

Phase 3

2,800

Badajoz, Barcelona, Córdoba, Girona, Madrid, Majadahonda, Talavera de la Reina, Valencia

2026-09-01

Not yet open

Retrospectively Investigating Longitudinal Outcomes in MED-EL SONATA 2 Cochlear Implant Recipients.

NCT07697911Cochlear Implantation, Sensorineural Hearing Loss

MED-EL Elektromedizinische Geräte GesmbH

Observational

200

Madrid, Valencia

2026-09

Not yet open

Radium-223 for High-Volume Metastatic Hormone Sensitive Prostate Cancer

NCT07717099Metastatic Hormone-Sensitive Prostate Cance

DrugsRa223·Darolutamide

Alianza multidisciplinar para la investigación de los tumores genitourinarios -GUARD

Phase 2

Barcelona, Las Palmas de Gran Canaria, Madrid, Oviedo, Santander, Santiago de Compostela, Valencia, Valladolid

2026-09

Recruiting

Effect of Holy Basil on Subjects With Sensitive Skin

NCT07811310Sensitive Skin Related to Stress

Laboratoires Expanscience S.A.

Not applicable

200

Valencia

2026-08-31

Recruiting

Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment

NCT07691970Systemic Sclerosis Cutaneous Lupus E Myopathies Systemic Lupus Erythematosus

DrugAnifrolumab

AstraZeneca

Phase 3

1,072

Barcelona, Castellon, Granada, Las Palmas de Gran Canaria, Madrid, Valencia, Vigo

2026-08-31

Recruiting

Activia Kefir Consumption in Real-world Setting

NCT07790666Kefir Usual Consumers and New Kefir Consumers

Danone Global Research & Innovation Center

Observational

550

Barcelona, Madrid, Valencia

2026-08-25

Recruiting

A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

NCT07761117Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)

DrugElecoglipron

AstraZeneca

Phase 3

6,950

Barcelona, Jaén, Madrid, Murcia, Salamanca, Sanlúcar de Barrameda (Cádiz), Seville, Valencia

2026-08-24

Recruiting

AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications

NCT07797335Type 2 Diabetes, Cardiovascular Risk

DrugZenagamtide

Novo Nordisk A/S

Phase 3

1,778

A Coruña, Barcelona, Móstoles, Sanlúcar de Barrameda, Santiago de Compostela, Segovia, Valencia

2026-08-24

Recruiting

Study of Denikitug (GS-1811) Given Alone or With Nivolumab or Chemotherapy in Adults With Metastatic Gastric, Gastroesophageal Junction (GEJ), and Esophageal Adenocarcinomas

NCT07546812HER2-negative, Gastroesophageal Junction, Esophageal Adenocarcinoma, Gastric Adenocarcinoma

DrugsDenikitug·Ramucirumab·Nivolumab·Paclitaxel

Gilead Sciences

Phase 2

120

Barcelona, Madrid, Valencia

2026-08-07

Recruiting

Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study

NCT07746895C3 Glomerulopathy (C3G), Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)

DrugPegcetacoplan

Swedish Orphan Biovitrum

Phase 4

150

A Coruña, Barcelona, Las Palmas, Madrid, Málaga, Valencia

2026-08-05

Recruiting

Phase 1/2 Multicenter, Open-label, Dose-escalation Study of IDP- 121 in Patients With Platinum-resistant Small Cell Lung Cancer (MYCrocytic)

NCT07864207Small Cell Lung Cancer ( SCLC )

DrugIDP-121

IDP Discovery Pharma S.L.

Phase 1/2

Barcelona, Las Palmas de Gran Canaria, Madrid, Málaga, Murcia, Pamplona, Santa Cruz de Tenerife, Valencia

2026-07-28

Recruiting

A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis

NCT07497087Systemic Sclerosis

Boehringer Ingelheim

Phase 3

448

Badalona, Barakaldo, Barcelona, Huelva, L'Hospitalet Del Llobregat, Madrid, Sabadell, Valencia

2026-07-27

Recruiting

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Inebilizumab in Children With Generalized Myasthenia Gravis (gMG)

NCT06987539Generalized Myasthenia Gravis

DrugInebilizumab

Amgen

Phase 2

Valencia

2026-07-21

Active, closed

Is Hypoxemia Driving Outcome in Acute Hypoxemic Respiratory Failure? (HOMELAND Study)

NCT07708506Acute Hypoxemic Respiratory Failure

Jesus Villar

Observational

1,241

Barakaldo, Albacete, Barcelona, León, Madrid, Murcia, Valencia, Valladolid

2026-07-13

Recruiting

DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer (epNEC) to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy

NCT07544654Extrapulmonary Neuroendocrine Cancer (epNEC)

DrugsObrixtamig·Etoposide·Carboplatin

Boehringer Ingelheim

Phase 3

390

Badalona, Barcelona, Madrid, Málaga, Pamplona, Santander, Seville, Valencia

2026-07-10

Recruiting

EEG Prediction and Clinical Efficacy of tDCS in Fibromyalgia.

NCT07583056Fibromyalgia (FM)

Ionclinics & Deionic SL

Not applicable

250

Valencia

2026-07-08

Not yet open

TNT With FLOT/Durvalumab Plus Post-OP Durvalumab for Resectable Gastroesophageal Adenocarcinoma

NCT07507968Esophagogastric Adenocarcinoma

DrugDurvalumab

Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest

Phase 2

101

Badalona, Barcelona, Granada, Jaén, Málaga, Oviedo, Pamplona, Valencia

2026-07-01

Not yet open

Evaluation of Calcified Coronary Lesion Preparation With the Naviscore Scoring Balloon

NCT07650578Coronary Arterial Disease (CAD), Calcific Coronary Arteriosclerosis

University of Mons

Not applicable

200

Barcelona, Cadiz, Cáceres, Valencia, Valladolid

2026-07

Not yet open

Combined Manual Therapy and Percutaneous Neuromodulation for Moderate Carpal Tunnel Syndrome

NCT07654621Carpal Tunnel Syndrome

Universidad Europea de Valencia

Not applicable

150

Valencia

2026-07

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity When Intravenous (IV) Pivekimab Sunirine is Given in Combination With Oral Venetoclax and IV or Subcutaneous Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML)

NCT07581002Acute Myeloid Leukemia

DrugsPivekimab Sunirine·Azacitidine·Venetoclax

AbbVie

Phase 2/3

660

Majadahonda, Pamplona, Seville, Madrid, Valencia

2026-06-30

Recruiting

A Study Evaluating the Prophylactic Use of Tocilizumab to Prevent Cytokine Release Syndrome With Ramantamig Administration in Participants With Relapsed/Refractory Multiple Myeloma

NCT07589634Multiple Myeloma

DrugsRamantamig·Tocilizumab

Janssen Research & Development, LLC

Phase 2

230

Madrid, Pamplona, Valencia

2026-06-30

Recruiting

Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT

NCT07764978Newly Diagnosed Multiple Myeloma

DrugsAZD0120·Isatuximab·Bortezomib·Daratumumab

AstraZeneca

Phase 3

750

Badalona, Barcelona, Madrid, Pamplona, Salamanca, Seville, Valencia

2026-06-26

Recruiting

Effects of Neurofeedback Training and tRNS on Attentional Deficits in Patients With Acquired Brain Injury

NCT07817316Acquired Brain Injury Including Stroke, TBI, Stroke, Anoxia-Ischemia, Brain

Hospitales Nisa

Not applicable

Valencia

2026-06-26

Recruiting

Safety and Performances of the LINEA Cardiac Pacing Lead Optimized for the Implantation in Interventricular Septum

NCT07342608Bradycardia, Left Bundle Branch Area Pacing, Left Bundle Branch Pacing

MicroPort CRM

Not applicable

450

Girona, Granada, Valencia

2026-06-23

Recruiting

A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)

NCT07554339Non-small Cell Lung Cancer

DrugsCalderasib·Durvalumab

Merck Sharp & Dohme LLC

Phase 3

310

Girona, Valencia, Barcelona, Madrid, Seville

2026-06-18

Recruiting

EEG Prediction and Clinical Efficacy of tDCS in Major Depression

NCT07611773Depression - Major Depressive Disorder

Ionclinics & Deionic SL

Not applicable

270

Valencia

2026-06-14

Recruiting

A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.

NCT07652658Idiopathic Pulmonary Fibrosis (IPF)

AstraZeneca

Phase 2

359

Barcelona, L'Hospitalet de Llobregat, Madrid, Málaga, Valencia

2026-06-11

Active, closed

A Study to Evaluate the Efficacy and Safety of Concomitant Use of Eplontersen and ALXN2220 Compared With Eplontersen and Placebo for Adults Participants With ATTR-CM

NCT07608354Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

DrugsCliramitug·Eplontersen

AstraZeneca

Phase 2

326

Barcelona, Jaén, L'Hospitalet de Llobregat, Majadahonda, Málaga, Pamplona, Salamanca, Valencia

2026-06-11

Recruiting

Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic Leukemia

NCT07504458Acute Promyelocytic Leukemia (APL), Acute Promyelocytic Leukaemia, Acute Promyelocytic Leukemia With PML-RARA, Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA

DrugsArsenic Trioxide·ATRA

Quetzal Therapeutics

Phase 3

150

Palma de Mallorca, Badalona, Barcelona, Cáceres, Málaga, Oviedo, Valencia

2026-06-08

Active, closed

Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments

NCT07468071Locally Advanced or Metastatic KRAS G12C-mutated Non-small Cell Lung Cancer, Advanced Solid Tumors Harboring the KRAS G12C Mutation

DrugsTNO155·Opnurasib·Trametinib·Cetuximab

Novartis Pharmaceuticals

Phase 1/2

Pamplona, Barcelona, Madrid, Valencia

2026-06-08

Recruiting

Study to Evaluate the Efficacy and Safety of Atezolizumab and Bevacizumab as Neoadjuvant Plus Adjuvant Treatment in HCC

NCT07018947Resectable Hepatocellular Carcinoma

DrugAtezolizumab and Bevacizumab

Fundacion Clinic per a la Recerca Biomédica

Phase 2

Badalona, Barcelona, Santander, Córdoba, Girona, Madrid, Puerto de la Torre, Valencia

2026-06-02

Recruiting

An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED

NCT07519902Persistent Corneal Epithelial Defect

DrugCenegermin

Dompé Farmaceutici S.p.A

Phase 3

150

A Coruña, Cardona, Badalona, Barcelona, Madrid, Málaga, Seville, Valencia

2026-06-02

Recruiting

Peri-implant Tissues Changes for Different Abutment Shapes and Heights

NCT07509281Dental Implant-Abutment Designs, Marginal Bone Loss in Different Abutment Designs, Soft Tissue Management in Subcrestal Dental Implants

University of Valencia

Not applicable

180

Valencia

2026-06-01

Recruiting

A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

NCT07613294Atherosclerosis, Cardiovascular Diseases, Lipoprotein(a)

DrugLepodisiran

Eli Lilly and Company

Phase 3

252

A Coruña, Barcelona, Córdoba, Las Palmas de Gran Canaria, Madrid, Seville, Valencia

2026-06-01

Not yet open

Effects of Dry Needling in Athletes With Subacromial Pain Syndrome

NCT07621016Subacromial Pain Syndrome

Universidad Europea de Valencia

Not applicable

Valencia

2026-06

Not yet open

Effectiveness of Virtual Reality in Parkinson's Disease: Effects on Balance, Fall Risk, and Exercise Capacity.

NCT07251231Parkinson Disease

University of Valencia

Not applicable

Valencia

2026-05-30

Recruiting

BIO|STREAM.CSP CLS

NCT07608822Sinus Node Disease, Atrioventricular Block

Biotronik SE & Co. KG

Observational

150

Madrid, Valencia

2026-05-29

Recruiting

BIO|STREAM.CSP Study

NCT07393009Cardiac Pacing, Cardiac Pacemaker, Implantable Cardioverter Defibrillator, Cardiac Resynchronization Therapy Devices

Biotronik SE & Co. KG

Observational

1,000

Barcelona, Madrid, Valencia

2026-05-25

Recruiting

A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer

NCT07525206Colorectal Cancer

DrugsTelisotuzumab Adizutecan·Trifluridine/Tipiracil·Bevacizumab

AbbVie

Phase 3

990

Barcelona, Córdoba, Madrid, Valencia, Zaragoza

2026-05-22

Recruiting

A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

NCT07422480Myelodysplastic Syndrome, Anemia

DrugsElritercept·Epoetin Alfa

Takeda

Phase 3

300

L'Hospitalet de Llobregat, Seville, Barcelona, Madrid, Málaga, Salamanca, Valencia

2026-05-21

Recruiting

A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)

NCT07124078Chronic Graft-versus-host-disease

DrugAxatilimab

Incyte Corporation

Phase 2

Barcelona, Esplugues de Llobregat, Madrid, Málaga, Murcia, Valencia

2026-05-20

Recruiting

A Clinical Study to Evaluate the Effects of NXT007 Compared to Factor VIII Prophylaxis in Participants With Hemophilia A

NCT07416526Hemophilia A

Hoffmann-La Roche

Phase 3

138

Barcelona, Madrid, Málaga, Seville, Valencia

2026-05-15

Active, closed

Implant Placement Depth and Peri-Implant Tissue Outcomes

NCT07535528Dental Implant Placement, Soft Tissue Management in Subcrestal Dental Implants, Marginal Bone Loss

University of Valencia

Not applicable

Valencia

2026-05-15

Recruiting

A Substudy of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis

NCT07571174Amyotrophic Lateral Sclerosis

DrugLY4256984

Eli Lilly and Company

Phase 1

L'Hospitalet de Llobregat, Valencia

2026-05-14

Recruiting

A Master Protocol (OLMP): A Study of LY4256984 in Participants With Amyotrophic Lateral Sclerosis (ALS)

NCT07571200Amyotrophic Lateral Sclerosis

DrugLY4256984

Eli Lilly and Company

Phase 1

L'Hospitalet de Llobregat, Valencia

2026-05-14

Recruiting

A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis

NCT07387549Primary Sclerosing Cholangitis

DrugElafibranor

Ipsen

Phase 3

350

Barcelona, Córdoba, Madrid, Pontevedra, Santander, Valencia, Zaragoza

2026-05-14

Recruiting

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

NCT07567001Obesity, Heart Failure

DrugNNC0487-0111

Novo Nordisk A/S

Phase 3

5,610

Sant Joan Despí, Valencia, A Coruña, Alcorcón, Antequera, Badalona, Barcelona, Bilbao

2026-05-11

Recruiting

An Open-label, Rollover Trial to Evaluate the Efficacy and Safety of AMG 732 in Participants With Thyroid Eye Disease

NCT07438405Thyroid Eye Disease

DrugAMG 732

Amgen

Phase 2

Seville, Valencia

2026-05-07

Recruiting

Urinary Chloride and Sodium Changes and Residual Congestion in Acute Heart Failure

NCT07597512Acute Heart Failure (AHF), Heart Failure, Congestion

Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal

Observational

223

Olot, Madrid, Majadahonda, Valencia

2026-05-06

Recruiting

A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies

NCT07415031Solid Tumors

DrugsAdagrasib·Fluorouracil·Leucovorin·Irinotecan

Mirati Therapeutics Inc.

Phase 2

170

A Coruña, Palma, Barcelona, Badalona, Santander, Madrid, Pamplona, Valencia

2026-05-06

By invitation

Pain Neuroscience Education for Chronic Pain

NCT07693998Fibromyalgia (FM), Chronic Low Back Pain (CLBP), Chronic Pain

University of Valencia

Not applicable

Valencia

2026-05-05

Recruiting

A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)

NCT07513376Non-small Cell Lung Cancer

DrugsPembrolizumab Formulated with Berahyaluronidase Alfa·Intismeran autogene

Merck Sharp & Dohme LLC

Phase 3

876

L'Hospitalet de Llobregat, Barakaldo, Barcelona, Málaga, Badajoz, Madrid, Seville, Valencia

2026-05-04

Active, closed

Family Connections Transdiagnostic for Relatives of People With Emotional Dysregulation

NCT07585955Relatives

University of Valencia

Not applicable

172

Valencia

2026-05-03

Recruiting

A Study in People With Advanced Cancer to Test How Well Different Doses of BI 3819026 Are Tolerated When Taken Alone and Together With Ezabenlimab

NCT07607678Advanced Solid Cancer, Metastatic Solid Cancer

DrugEzabenlimab

Boehringer Ingelheim

Phase 1

Barcelona, Pamplona, Valencia

2026-05-01

By invitation

Perceptions of Key Domains of Home-Based Palliative Care Among Healthcare Professionals (MULTIPAL)

NCT07554209Home Care, Hospital-Based, Palliative Care, Health Services Research, Decision Making

Instituto de Investigacion Sanitaria La Fe

Observational

580

Valencia

2026-05-01

Not yet open

Impact of Dietary Fat and Menstrual Cycle Phases in Type 1 Diabetes

NCT07278063Type 1 Diabetes Mellitus, Glycemic Variability, Sex Characteristics, Menstrual Cycle

Instituto de Investigacion Sanitaria La Fe

Not applicable

Valencia

2026-05

Recruiting

Observational Study of Adults and Adolescents With Erythropoietic Protoporphyria (EPP) and X-linked Porphyria (XLP)

NCT07567131Erythropoietic Protoporphyria (EPP), X-Linked Porphyria (XLP)

Portal Therapeutics, Inc.

Observational

Madrid, Valencia

2026-04-30

Recruiting

A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms

NCT07469891Polycythemia Vera (PV), Myelofibrosis (MF), Myeloproliferative Neoplasms (MPNs), Post-Polycythemia Vera Myelofibrosis

Prelude Therapeutics Incorporated

Phase 1

100

Barcelona, Madrid, Valencia

2026-04-29

Recruiting

Timing of Comprehensive Local Treatment After First-Line Systemic Therapy in Oligometastatic Esophageal or Gastric Adenocarcinoma

NCT07000253Esophageal Cancer, Gastric (Stomach) Cancer, Gastric Adenocarcinoma, Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Phase 2

290

Valencia

2026-04-29

Recruiting

A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A

NCT07416604Hemophilia A

DrugEmicizumab

Hoffmann-La Roche

Phase 3

360

Barcelona, Madrid, Málaga, Seville, Valencia

2026-04-27

Recruiting

An Adaptive Program of IKT-001 in Pulmonary Arterial Hypertension (PAH)

NCT07365332Pulmonary Arterial Hypertension

Inhibikase Therapeutics

Phase 3

486

Málaga, Barcelona, Santander, Madrid, Marbella, Seville, Toledo, Valencia

2026-04-23

Recruiting

Study of Tarlatamab + ZL-1310 +/- Anti-programmed Death Ligand 1 (Anti-PD-L1) in Small Cell Lung Cancer (SCLC)

NCT07531095Small Cell Lung Cancer

DrugsZL-1310·Tarlatamab·Durvalumab

Amgen

Phase 1

160

Málaga, Barcelona, Valencia, Madrid

2026-04-21

Recruiting

Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015)

NCT07486960Psoriatic Arthritis

DrugTulisokibart

Merck Sharp & Dohme LLC

Phase 2

140

Santiago de Compostela, Barcelona, Madrid, Valencia

2026-04-20

Recruiting

EncompaSSc: Evaluation of MTX-474 in Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)

NCT07287670Diffuse Cutaneous Systemic Sclerosis

Mediar Therapeutics

Phase 2

Barcelona, Córdoba, Málaga, Valencia

2026-04-16

Recruiting

Remibrutinib Open Label Roll-over Post-trial Access Protocol

NCT07456891Indication of the Parent Protocol

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

648

Barcelona, Alicante, Córdoba, Madrid, Valencia

2026-04-16

Recruiting

Pacritinib For Bone Marrow Fibrosis In Patients With Myelofibrosis Who Have Thrombocytopenia

NCT07394153Myelofibrosis，MF

DrugPacritinib

Grupo Español de Enfermedades Mieloproliferativas Crónicas PH Negativas

Phase 2

Barcelona, Jerez de la Frontera, Madrid, Murcia, Salamanca, Valencia

2026-04-15

Recruiting

A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus

NCT07430306Systemic Lupus Erythematosus

DrugAnifrolumab

AstraZeneca

Phase 3

245

Barcelona, Córdoba, Galdakao, Madrid, Sabadell, Santander, Seville, Valencia

2026-04-13

Recruiting

A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

NCT07522073Solid Tumors

DrugINCB161734

Incyte Corporation

Phase 3

588

Badalona, Barcelona, Las Palmas de Gran Canaria, Madrid, Palma de Mallorca, Santander, Seville, Valencia

2026-04-09

Recruiting

A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)

NCT07489495Carcinoma, Renal Cell

DrugsZanzalintinib·Belzutifan

Merck Sharp & Dohme LLC

Phase 3

758

Seville, L'Hospitalet de Llobregat, Madrid, Barcelona, Las Palmas, Valencia

2026-04-09

Recruiting

Phase 1 Open Label Trial of MST-0312 Alone and in Combination in Subjects With Solid Malignancies

NCT07610941Cancer-Neoplasms

DrugsKeytruda·Pembrolizumab

Mestag Therapeutics Limited

Phase 1

157

Barcelona, Madrid, Valencia

2026-04-09

Recruiting

A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

NCT07405801Breast Cancer

DrugsInavolisib·Ribociclib·Fulvestrant

Hoffmann-La Roche

Phase 2

L'Hospitalet de Llobregat, Barcelona, Granada, Madrid, Valencia

2026-04-07

By invitation

Vascular Access and Intraosseus

NCT07471555To Compare the Time Required to Administer 1 mg of Epinephrine, as Well as the Total Procedure

University of Valencia

Not applicable

Valencia

2026-04-02

Not yet open

Extended Versus Short Prehabilitation Programme for Patients With Advanced Ovarian Cancer Undergoing Major Surgery

NCT07509814Ovarian Cancer With Peritoneal Carcinosis

Hospital Clinic of Barcelona

Not applicable

225

Badalona, Barcelona, Madrid, Pamplona, Valencia

2026-04-01

Recruiting

A Study of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors

NCT07407933Thoracic Neoplasms, Lung Diseases, Small Cell Lung Carcinoma

DrugsTam-Peli·Atezolizumab

MediLink Therapeutics (Suzhou) Co., Ltd.

Phase 1/2

118

Badajoz, Badalona, Barcelona, Girona, Madrid, Manresa, Seville, Valencia

2026-03-31

Recruiting

Acute Effects of Radiofrequency Diathermy in Postpartum Women With Diastasis Abdominis

NCT07419399Postpartum, Rectus Muscle Diastasis

University of Valencia

Not applicable

Valencia

2026-03-30

Recruiting

A Study to Assess the Effects of Zigakibart on IgA Nephropathy.

NCT07146906Immunoglobulin A Nephropathy (IgAN)

DrugZigakibart

Novartis Pharmaceuticals

Phase 2

Pamplona, Valencia, Barcelona, Seville

2026-03-26

Recruiting

Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall Health in Adults With a Metabolically Challenging Profile

NCT07504068Aging, Adults With Overweight and Obesity, Supplementation, Exercise

University of Valencia

Not applicable

Valencia

2026-03-25

Recruiting

Transition to KPL-387 Monotherapy Dosing & Administration Study

NCT07288216Recurrent Pericarditis, Heart Diseases, Pericarditis

DrugKPL-387

Kiniksa Pharmaceuticals International, plc

Phase 2

120

Barcelona, Madrid, Valencia

2026-03-25

Recruiting

Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial

NCT07293260Cardiovascular Disease

DrugOlpasiran

Amgen

Phase 3

406

Seville, Vigo, Valencia, Madrid

2026-03-23

Recruiting

PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease

NCT07355296Proteinuric Kidney Diseases

DrugApecotrep

Boehringer Ingelheim

Phase 2

132

Barcelona, Esplugues de Llobregat, Granada, Madrid, Valencia

2026-03-23

Recruiting

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

NCT07351045Obesity or Overweight

Hoffmann-La Roche

Phase 3

2,000

Santander, A Coruña, Pamplona, Barcelona, Madrid, Seville, Valencia

2026-03-16

Recruiting

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

NCT07361497Non-small Cell Lung Cancer (NSCLC)

DrugsPumitamig·Durvalumab

Bristol-Myers Squibb

Phase 3

850

L'Hospitalet Del Llobregat, Barcelona, Madrid, Valencia, Barakaldo, Málaga, Seville, Zaragoza

2026-03-16

By invitation

FINE-START: Efficacy and Safety of Finerenone in Patients With Chronic Kidney Disease Not Using Renin-angiotensin-system Inhibitors

NCT07181135Chronic Kidney Disease

DrugFinerenone

University Medical Center Groningen

Phase 3

180

Barcelona, Madrid, Pamplona, Valencia

2026-03-13

Recruiting

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

NCT07221149Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

DrugsPumitamig·Folfox·Nivolumab

Bristol-Myers Squibb

Phase 2/3

690

Barcelona, Santander, Pamplona, Valencia, Madrid, Málaga

2026-03-13

Recruiting

A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer

NCT07287150Metastatic Castration-Resistant Prostate Cancer

DrugsInavolisib·Abiraterone·Enzalutamide·Docetaxel

Hoffmann-La Roche

Phase 2

100

Barakaldo, Córdoba, Madrid, Valencia

2026-03-11

Recruiting

A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease

NCT07332481Systemic Lupus Erythematosus (SLE), Cutaneous Lupus Erythematosus (CLE)

DrugEnpatoran

EMD Serono Research & Development Institute, Inc.

Phase 3

202

Santiago de Compostela, Valencia

2026-03-10

Recruiting

Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

NCT07491445Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma

DrugsCetuximab·Nab-paclitaxel·Gemcitabine

Revolution Medicines, Inc.

Phase 3

900

Madrid, Valencia

2026-03-09

Recruiting

Exercise-induced Hypoalgesia Effects of Blood Flow Restriction in People With Rotator Cuff-related Shoulder Pain

NCT07232511Rotator Cuff Related Shoulder Pain

University of Valencia

Not applicable

Valencia

2026-03-05

Recruiting

MELIORA Virtual Coach Intervention for Breast Cancer Prevention

NCT07200427Breast Cancer Prevention

Harokopio University

Not applicable

2,080

Valencia

2026-03-01

Not yet open

Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects With Reduced Ejection Fraction

NCT07403058Heart Failure With Reduced Ejection Fraction (HFrEF)

Axon Therapies, Inc.

Not applicable

Valencia

2026-03-01

Recruiting

Acute Exercise Responses With Blood Flow Restriction Under Dynamic Pressure Compared to Fixed Pressure in Patients With Severe Gonarthrosis

NCT07316933Severe Knee Osteoarthritis

University of Valencia

Not applicable

Valencia

2026-03-01

Recruiting

Acute Effects of Blood Flow Restriction Training to Failure on Hypoalgesia in Patients With Severe Knee Osteoarthritis Using Dynamic or Fixed Occlusion Pressure

NCT07300384Severe Knee Osteoarthritis

University of Valencia

Not applicable

Valencia

2026-02-25

Recruiting

Acute Effects of Aerobic Exercise and High-intensity Interval Exercise With Immersive Virtual Reality

NCT07101341Acute Effects of Exercise in Healthy People, Health Adult Subjects

University of Valencia

Not applicable

Valencia

2026-02-25

Active, closed

A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)

NCT07400653Obesity, Overweight and/or Obesity, Overweight, Diabetes, Type 2

DrugBerobenatide

Pfizer

Phase 3

1,078

Málaga, Barcelona, Castilleja de la Cuesta, Chiclana de la Frontera, Madrid, Sanlúcar de Barrameda, Seville, Valencia

2026-02-24

Recruiting

A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

NCT07391657Relapsed Refractory Multiple Myeloma

DrugsAZD0120·Darzalex·Velcade·Carfilzomib

AstraZeneca

Phase 3

508

Barcelona, Madrid, Pamplona, Salamanca, Santander, Valencia

2026-02-23

Recruiting

To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer

NCT07368998Breast Cancer

DrugsInavolisib·Fulvestrant

Hoffmann-La Roche

Phase 2

Barcelona, Granada, Madrid, Valencia

2026-02-18

Recruiting

A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)

NCT07318558Ovarian Neoplasms, Ovarian Cancer

DrugsMvasi·Sacituzumab tirumotecan·Avastin·Bevacizumab

Merck Sharp & Dohme LLC

Phase 3

900

Girona, A Coruña, Madrid, Valencia, Barcelona, Córdoba

2026-02-16

Recruiting

First-in-human (FIH) Trial of GEN3018 in Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) or Higher-risk Myelodysplastic Syndrome (HR-MDS)

NCT07384715R/R AML, R/R HR-MDS, Acute Myeloid Leukemia, Higher-Risk Myelodysplastic Syndrome

Genmab

Phase 1

Barcelona, Madrid, Valencia

2026-02-16

Recruiting

Oral Health Education for Pregnant Women

NCT07413393Knowledge, Oral Health, Pregnant Women, Intervention

University of Valencia

Not applicable

300

Valencia

2026-02-15

Not yet open

Effects of Gender-Affirming Hormone Therapy on Cardiovascular, Metabolic, and Mental Health Outcomes in Transgender Adults.

NCT07394400Transgender Individuals

Milagros Rocha Barajas

Observational

Valencia

2026-02-14

Recruiting

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

NCT07215702Sepsis, Acute Kidney Injury

DrugAZD4144

AstraZeneca

Phase 2

124

Barcelona, Jerez de la Frontera, Valencia

2026-02-10

Recruiting

A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)

NCT07222332Diabetes Mellitus, Type 1

DrugBaricitinib

Eli Lilly and Company

Phase 3

300

Barakaldo, Barcelona, Esplugues de Llobregat, Madrid, Santander, Seville, Valencia

2026-02-05

Recruiting

Administration of Extracellular Vesicles From Donor Human Milk in Preterm Infants

NCT07402083Very Preterm Infants (<32 Weeks of Gestation)

Instituto de Investigacion Sanitaria La Fe

Observational

Valencia

2026-02-05

Recruiting

Safety and Efficacy of GYA01 (CART84) in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) and Acute Lymphoblastic T Leukemia Patients (T-ALL).

NCT07471789Acute Myeloblastic Leukaemia, Leukemia, T-Cell

Gyala Therapeutics

Phase 1/2

Barcelona, Valencia

2026-02-04

Recruiting

A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma

NCT07258511Multiple Myeloma

DrugsRamantamig·Teclistamab

Janssen Research & Development, LLC

Phase 3

400

Badalona, Barcelona, Granada, Madrid, Pozuelo de Alarcón, Salamanca, Usansolo, Valencia

2026-02-04

Recruiting

Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

NCT07431281Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Esophageal Cancer

DrugsSonesitatug Vedotin·Zolbetuximab·Rilvegostomig·Leucovorin

AstraZeneca

Phase 3

2,130

Barcelona, Madrid, Pamplona, Santander, Santiago de Compostela, Valencia

2026-02-03

Recruiting

Virtual Assistant for Exercise Adherence in Older ADULTS

NCT07498530Older Adult, Exercise, Adherence, Prevention

University of Valencia

Not applicable

Valencia

2026-02-01

Recruiting

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

NCT07322003Amyotrophic Lateral Sclerosis

DrugPridopidine

Prilenia

Phase 3

500

Barcelona, Madrid, Santiago de Compostela, Valencia

2026-02-01

Not yet open

Yttrium-90 Radioembolization Neoadjuvant Therapy With Immune Marker Profiling and Dosimetry for Potentially Resectable Patients With Colorectal Liver Metastases

NCT07406126Colorectal Liver Metastases (CRCLM), Unresectable Colorectal Liver Metastases

Fernando Gómez Muñoz

Observational

Pamplona, Castelló, Granada, Madrid, Valencia

2026-02

Recruiting

Study to Assess the Efficacy and Safety of Rina-S in Participants With Non-small Cell Lung Cancer

NCT07288177Non-small Cell Lung Cancer (NSCLC)

DrugRina-S

Genmab

Phase 2

240

A Coruña, Barcelona, Las Palmas de Gran Canaria, Logroño, Madrid, Málaga, Pamplona, Valencia

2026-01-30

Recruiting

Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

NCT07227298Advanced/Metastatic Non-Small Cell Lung Cancer, Carcinoma, Non-Small Cell Lung, Non-Small Cell Lung Cancer

DrugsSigvotatug vedotin·PF-08634404

Pfizer

Phase 1/2

162

Jaén, Barcelona, Jerez de la Frontera, Madrid, Málaga, Valencia, Cadiz, Granada

2026-01-30

Recruiting

Neoadjuvant Darovasertib in Primary Uveal Melanoma

NCT07015190Uveal Melanoma

DrugDarovasertib

IDEAYA Biosciences

Phase 3

520

Santiago de Compostela, L'Hospitalet de Llobregat, Pamplona, Valencia, Valladolid, Seville

2026-01-25

Recruiting

Study of ABBV-142 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Idiopathic Pulmonary Fibrosis

NCT07230288Idiopathic Pulmonary Fibrosis

AbbVie

Phase 2

165

Valencia

2026-01-23

Recruiting

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

NCT07216703Cervical Cancer

DrugsMvasi·Sacituzumab tirumotecan·Paraplatin·Avastin

Merck Sharp & Dohme LLC

Phase 3

1,023

Girona, Valencia, Barcelona, Córdoba, Madrid

2026-01-19

Not yet open

Personalised Pharmacometabolomic-guided Strategy Trial to Optimise Treatment for Hypertension

NCT07294794Hypertension

University of Birmingham

Not applicable

400

Valencia

2026-01-19

Not yet open

Effects of Resistance and Dual-Task Training on Physical, Oculomotor, and Executive Functions in Older Adults With MCI

NCT07278141Physical Function, Executive Function (Cognition), Saccadic Eye Movements

Universidad Santo Tomas, Chile

Not applicable

Valencia

2026-01-17

Recruiting

Non-invasive Brain Stimulation on Functional Capacity in Prefrail Older Adults

NCT07346989Prefrail Elderly

University of Valencia

Not applicable

Valencia

2026-01-15

By invitation

Intradialytic Exercise Program Supported by Audiovisual Media Combined With Mindfulness

NCT07499856Chronic Kidney Disease (Stages 3b-5)

Cardenal Herrera University

Not applicable

Valencia

2026-01-14

Recruiting

A Study of Gammagard Liquid (Immune Globulin Infusion, 10%) to Prevent Infections in Adults With Multiple Myeloma

NCT06980480Multiple Myeloma, Secondary Immunodeficiency

Takeda

Phase 3

183

Madrid, Marbella, Palma de Mallorca, Salamanca, Valencia

2026-01-14

Active, closed

Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes

NCT07284901Obesity With Diabetes, Overweight With Diabetes

DrugRibupatide

Kailera

Phase 3

1,270

Ferrol, Seville, Villamartín, Barcelona, Oviedo, Castilleja de la Cuesta, Madrid, Valencia

2026-01-12

Recruiting

Study to Evaluate the Efficacy, Safety, and Tolerability of PIPE 791 in Subjects With Idiopathic Pulmonary Fibrosis

NCT07284459Idiopathic Pulmonary Fibrosis

Contineum Therapeutics

Phase 2

324

Málaga, Valencia

2026-01-08

Active, closed

Pharmacokinetic Study of Rezafungin in Patients With Suspected Intra-Abdominal Candidiasis

NCT06985758Candidal Peritonitis

Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal

Phase 4

Madrid, Valencia

2026-01-07

By invitation

Lead Evaluation for Defibrillation and Reliability Post Approval Study

NCT07005232Tachyarrhythmia

Medtronic

Observational

2,000

Granada, A Coruña, Madrid, Santa Cruz de Tenerife, Valencia

2026-01-07

Recruiting

A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

NCT07063745Metastatic Non-small Cell Lung Cancer With MTAP Deletion

DrugsNavlimetostat·Nab-paclitaxel·Pemetrexed·Paclitaxel

Bristol-Myers Squibb

Phase 2/3

590

Barcelona, Hospitalet, Madrid, Majadahonda, Málaga, Seville, Valencia

2026-01-02

Recruiting

Impact of UFPs and MNPs on Fetal Health

NCT07238608Pregnant Women

Instituto de Investigacion Sanitaria La Fe

Observational

1,600

Valencia

2026-01-01

Recruiting

Impact of Abutment Screw Torque on Marginal Bone Loss

NCT07234552Soft Tissues According to the Abutment Torque, Microleakage Accordint to the Abutment Torque, PROMS According to the Abutment Torque, Marginal Bone Loss According to the Abutment Torque

University of Valencia

Not applicable

Valencia

2026-01-01

Active, closed

Serious Game-Based School Intervention to Enhance Socio-Emotional Competence and Well-Being in European Adolescents

NCT07093645None - Study is to Determine Safety in Healthy Participants

University of Valencia

Not applicable

500

Valencia

2026-01-01

Recruiting

A Study to Evaluate Adrixetinib (Q702) in Adults With Active Chronic Graft-Versus-Host Disease

NCT07138196Chronic Graft-Versus-Host Disease

DrugAdrixetinib

Qurient Co., Ltd.

Phase 1

Barcelona, Madrid, Majadahonda, Murcia, Pamplona, Santander, Seville, Valencia

2025-12-23

Recruiting

A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant

NCT06932562Multiple Myeloma

DrugsLinvoseltamab·Daratumumab·Lenalidomide·Dexamethasone

European Myeloma Network B.V.

Phase 3

1,000

Badalona, Barcelona, Madrid, Santander, Valencia

2025-12-23

Recruiting

Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma

NCT07265947Low Grade Upper Tract Urothelial Carcinoma

DrugTYRA-300

Tyra Biosciences, Inc

Phase 2

230

Valencia, Cadiz, Madrid

2025-12-22

Recruiting

A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

NCT07225946Prostatic Neoplasms, Castration-Resistant

DrugsPasritamig·Prednisone/Prednisolone·Docetaxel

Janssen Research & Development, LLC

Phase 3

800

Badalona, Madrid, Murcia, Seville, Valencia, Zaragoza

2025-12-19

Active, closed

Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

NCT07311850Obesity and Overweight

DrugBerobenatide

Pfizer

Phase 3

3,578

Málaga, Castilleja de la Cuesta, Chiclana de la Frontera, Madrid, Sanlúcar de Barrameda, Seville, Valencia

2025-12-19

Recruiting

A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

NCT07266831Human Immunodeficiency Virus Type 1 (HIV-1) Infection

DrugB/F/TAF

Merck Sharp & Dohme LLC

Phase 2/3

570

Madrid, Valencia, Barcelona, Málaga

2025-12-18

Recruiting

CURENDO (Cord-blood Uterine Regeneration Endometrium): Platelet-rich Plasma Therapy Derived From Umbilical Cord Blood for the Treatment of Endometrial Pathologies (Asherman Syndrome / Endometrial Atrophy / Thin Endometrium)

NCT07697924Asherman Syndrome

Fundación IVI

Not applicable

Valencia

2025-12-18

Active, closed

Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

NCT07284875Obesity, Overweight

DrugRibupatide

Kailera

Phase 3

2,530

Ferrol, Seville, Villamartín, Barcelona, Oviedo, Castilleja de la Cuesta, Madrid, Valencia

2025-12-18

Recruiting

Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations

NCT07185997Non-Small-Cell Lung Cancer, Metastatic Non-Small-Cell Lung Cancer, Advanced Non-Small-Cell Lung Cancer, EGFR P-Loop and Alpha C-Helix Compressing

DrugFurmonertinib

ArriVent BioPharma, Inc.

Phase 3

480

Palma, Barcelona, Málaga, Oviedo, Valencia

2025-12-17

By invitation

Implementation of a Suicide Prevention Gatekeeper Program in the University Setting

NCT07052240Suicide Prevention, Suicide Awareness, Suicide Behavior

University of Valencia

Not applicable

420

Valencia

2025-12-15

Recruiting

A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis

NCT07276581Rheumatoid Arthritis

AstraZeneca

Phase 2

320

Barcelona, Málaga, Sabadell, Santiago de Compostela, Valencia

2025-12-15

Recruiting

Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

NCT07252232Pancreatic Cancer, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma (PDAC)

DrugCetuximab

Revolution Medicines, Inc.

Phase 3

500

Pamplona, Barcelona, Madrid, Seville, Valencia

2025-12-15

Recruiting

Supplement and Exercise Effects on Stationary Immunity and Health in Older Adults

NCT07251244Aging, Older Adults

University of Valencia

Not applicable

Valencia

2025-12-15

Recruiting

Impact of Funcional Exercise and Supplementation in Perimenopausal Women's Health

NCT07251296Perimenopause, Aging

University of Valencia

Not applicable

Valencia

2025-12-15

Recruiting

INFLATE Study: Investigation of the Safety and Performance of a Novel PTV Balloon in Patients Undergoing TAVI for Severe Aortic Stenosis

NCT06816485Aortic Diseases

Biosensors Europe SA

Not applicable

Barcelona, Córdoba, Huelva, Madrid, Seville, Valencia, Valladolid

2025-12-15

Recruiting

An Early Phase Trial of RPTR-1-201 in Advanced Solid Tumors

NCT07293754Advanced Malignant Solid Tumor

Repertoire Immune Medicines

Phase 1/2

150

Barcelona, Logroño, Madrid, Pamplona, Valencia

2025-12-12

Recruiting

BaLloon-based PFA Ablation poST Approval Outcomes for PAF and PersAF

NCT07181590Paroxysmal AF, Atrial Arrhythmia, Atrial Fibrillation, Persistent Atrial Fibrillation

Abbott Medical Devices

Not applicable

300

A Coruña, Madrid, Valencia

2025-12-11

Recruiting

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

NCT07222800Intestinal Neoplasms, Gastrointestinal Neoplasms, Digestive System Neoplasms, Neoplasms by Site

DrugsPF-08634404·Avastin·Bevacizumab

Pfizer

Phase 3

800

Santiago de Compostela, Málaga, Barcelona, L'Hospitalet de Llobregat, Jerez de la Frontera, Madrid, Córdoba, Valencia

2025-12-11

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

NCT07155187Non-Small Cell Lung Cancer, c-MET

DrugsTelisotuzumab Adizutecan·Osimertinib

AbbVie

Phase 2/3

490

Santiago de Compostela, Sabadell, Barcelona, Madrid, Málaga, Valencia, Zaragoza

2025-12-10

Recruiting

Assessment of Weight-bearing Ankle Range of Motion Using the Ankle Test and Lower Body Test and Its Relationship With Ligamentous Hyperlaxity in Child Basketball Players Aged 8 to 15 Years

NCT07589218Ligamentous Hypermobility of the Toe, Children Basketball Players

Benjamín Cuenca Valero

Observational

Valencia

2025-12-09

Active, closed

Phase 2 Study of SAT-3247 in Pediatric Ambulatory Patients

NCT07287189Duchenne Muscular Dystrophy, Duchenne, DMD, Neuromuscular Diseases

DrugSAT-3247

Satellos Bioscience, Inc.

Phase 2

Donostia / San Sebastian, Valencia, Barcelona

2025-12-08

Recruiting

A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

NCT07276399Squamous Cell Carcinoma of Head and Neck

DrugsAmivantamab·Cisplatin·Carboplatin·Pembrolizumab

Janssen Research & Development, LLC

Phase 3

500

Barcelona, L'Hospitalet de Llobregat, Madrid, Pamplona, Santiago de Compostela, Valencia, Zaragoza

2025-12-03

Recruiting

A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

NCT07218926Gastrointestinal Neoplasms

DrugsIDRX-42·Sunitinib

GlaxoSmithKline

Phase 3

450

Barcelona, Madrid, Oviedo, Seville, Valencia, Zaragoza

2025-12-03

Recruiting

EmoTIChealth: Promoting Adolescent Health Through a Serious Game.

NCT07212530Type 1 Diabetes, Asthma, Allergic Rhinitis, Food Allergy

University of Valencia

Not applicable

600

Valencia

2025-12-01

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan

NCT07196644Solid Tumors Harboring MET Amplification

DrugTelisotuzumab Adizutecan

AbbVie

Phase 2

100

Pamplona, Barcelona, Madrid, Valencia

2025-12-01

Recruiting

An Efficacy and Safety Study of DFL24498 in the Treatment of AKC

NCT07395232Atopic Keratoconjunctivitis

DrugDFL24498

Dompé Farmaceutici S.p.A

Phase 3

153

Córdoba, Santiago de Compostela, Valencia, Valladolid, Zaragoza

2025-12-01

Recruiting

A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)

NCT07218146Small-cell Lung Cancer

DrugZL-1310

Zai Lab (Shanghai) Co., Ltd.

Phase 3

480

Valencia, Barcelona, Elche, Girona, Jerez de la Frontera, Madrid, Málaga, Pamplona

2025-11-30

Recruiting

Effects of tDCS on Motor Cortex During ACL Recovery

NCT06818201Anterior Cruciate Ligament Reconstruction Rehabilitation

Fundación Universidad Católica de Valencia San Vicente Mártir

Not applicable

Valencia

2025-11-28

Recruiting

Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer

NCT07166094Endometrial Cancer, Recurrent or Progressive Endometrial Cancer

DrugRina-S

Genmab

Phase 3

660

Palma de Mallorca, Barcelona, Girona, A Coruña, Madrid, Málaga, Pamplona, Valencia

2025-11-28

Recruiting

Orofacial Pain Self-management: Personality Moderation Effect

NCT06932406Chronic Orofacial Pain, Temporomandibular Disorder (TMD), Temporomandibular Disorders (TMD), Temporomandibular Dysfunction (TMD)

Fundación Universidad Católica de Valencia San Vicente Mártir

Not applicable

Valencia

2025-11-28

Recruiting

A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD

NCT06847542Neovascular Age-related Macular Degeneration

DrugRanibizumab

Hoffmann-La Roche

Phase 3

250

Madrid, Seville, Valencia

2025-11-27

Recruiting

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

NCT07227402Renal Cell Carcinoma

DrugsZanzalintinib·Belzutifan·Cabozantinib

Merck Sharp & Dohme LLC

Phase 3

904

L'Hospitalet de Llobregat, Santander, Girona, Madrid, Valencia, Barcelona, Córdoba

2025-11-26

Recruiting

A Platform Study in Non-Small Cell Lung Cancer (NSCLC)

NCT06996782Advanced or Metastatic Non-small Cell Lung Cancer

DrugsRamucirumab·Rilvegostomig·Nab-paclitaxel·Pemetrexed

AstraZeneca

Phase 1/2

152

Barcelona, L'Hospitalet de Llobregat, Madrid, Pamplona, Pozuelo de Alarcón, Valencia

2025-11-24

Recruiting

REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants

NCT07213778Symptomatic Venous Thromboembolism (VTE)

DrugsCenvacibart·Acetylsalicylic acid

Regeneron Pharmaceuticals

Phase 3

2,000

Vitoria-Gasteiz, Marbella, Pamplona, Barcelona, Madrid, Valencia

2025-11-24

Recruiting

Nutritional Management of the Patient With Type 2 Diabetes at Nutritional Risk or With Malnutrition in Clinical Practice

NCT07252765Type 2 Diabetes Mellitus (T2DM), Malnutrition, Malnourishment, Drug-Induced Diabetes

Outcomes'10

Observational

334

Santander, Huelva, Las Palmas de Gran Canaria, Madrid, Málaga, Oviedo, Seville, Valencia

2025-11-20

Recruiting

Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen

NCT07087054Carcinoid Syndrome, Carcinoid, Carcinoid Tumor, Carcinoid Tumor of Ileum

Crinetics Pharmaceuticals Inc.

Phase 3

141

Barcelona, Madrid, Málaga, Seville, Valencia

2025-11-19

Recruiting

A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer

NCT06948448Colorectal Cancer

DrugsONO-4578·Leucovorin·Opdivo·Adrucil

Ono Pharmaceutical Co., Ltd.

Phase 2

144

Badalona, Barcelona, Córdoba, Madrid, Seville, Málaga, Valencia

2025-11-18

Recruiting

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis

NCT07219420Palmoplantar Pustulosis

DrugBimekizumab

UCB Biopharma SRL

Phase 3

320

Alicante, Badalona, Granada, Madrid, Manises, Málaga, Santiago de Compostela, Valencia

2025-11-14

Active, closed

A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

NCT07170150Alzheimers Disease

DrugTrontinemab

Hoffmann-La Roche

Phase 3

1,060

Santander, Barcelona, Madrid, Seville, Valencia

2025-11-12

Recruiting

A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

NCT07023627Ovarian Cancer

DrugINCB123667

Incyte Corporation

Phase 2

160

Barcelona, Córdoba, Girona, Madrid, Murcia, Valencia

2025-11-12

Recruiting

Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Acute Lymphoblastic Leukemia

NCT07109219B-cell Acute Lymphoblastic Leukemia (B-ALL)

AstraZeneca

Phase 1/2

Badalona(Barcelona), Barcelona, Salamanca, Santander, Valencia

2025-11-12

Recruiting

Validation of the Sentinel Lymph Node Technique in Early-stage Ovarian Cancer (SENTOV II)

NCT06963268Ovarian Neoplasms

Instituto de Investigacion Sanitaria La Fe

Phase 3

200

Valencia

2025-11-10

Recruiting

Phase 2 Study of ADX-038 in Participants With Geographic Atrophy

NCT06990269Geographic Atrophy Secondary to Age-related Macular Degeneration

ADARx Pharmaceuticals, Inc.

Phase 2

240

Barcelona, Madrid, Valencia

2025-11-10

Recruiting

A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization

NCT07088926Bronchiectasis With Pseudomonas Aeruginosa Colonization

DrugAZD0292

AstraZeneca

Phase 2

435

Barcelona, Benalmádena, Madrid, Mérida, Patraix, Valencia

2025-11-06

Recruiting

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

NCT07100080Non-Small Cell Lung Cancer

DrugsIza-bren·Pemetrexed·Cisplatin·Carboplatin

Bristol-Myers Squibb

Phase 2/3

500

Barcelona, Madrid, Majadahonda, Málaga, Seville, Valencia, Zaragoza

2025-11-05

Recruiting

Effects of Staged Adapted Inclusions in Infant Cereals on Oral-motors Patterns of 6-24 Month-old Children

NCT07318506Healthy, Infant and Young Child Feeding

Société des Produits Nestlé (SPN)

Not applicable

153

Barcelona, Valencia

2025-11-05

Recruiting

Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

NCT07007065Neovascular Age-related Macular Degeneration

DrugSurabgene Lomparvovec

AbbVie

Phase 3

561

Córdoba, Donostia / San Sebastian, Majadahonda, Asturias, Seville, Barcelona, Madrid, Valencia

2025-11-05

Recruiting

A Study of AZD2962, an IRAK4 Inhibitor (IRAK4 [a Body Protein] Blocker), in Participants With Haematologic Neoplasms (Blood Cancers)

NCT07064122Haematologic Neoplasms

AstraZeneca

Phase 1

Barcelona, Madrid, Pamplona, Salamanca, Valencia

2025-11-03

Recruiting

A Phase II Trial to Evaluate the Clinical Efficacy, Safety and Tolerability of MAS825 in Pediatric and Adult Participants With Still's Disease

NCT07203001Still´s Disease

DrugArumakimig

Novartis Pharmaceuticals

Phase 2

Esplugues, Madrid, Valencia

2025-11-03

Active, closed

A Study Evaluating BFB759 in Moderate to Severe Hidradenitis Suppurativa

NCT07287644Hidradenitis Suppurativa (HS)

DrugBFB759

Bluefin Biomedicine, Inc.

Phase 2/3

210

Granada, Granollers, Las Palmas de Gran Canaria, Madrid, Pontevedra, Valencia

2025-11-03

Recruiting

A Study of Zasocitinib in Adults With Nonsegmental Vitiligo

NCT07108283Nonsegmental Vitiligo

DrugZasocitinib

Takeda

Phase 2

200

Las Palmas de Gran Canaria, Córdoba, Madrid, Valencia

2025-11-03

Not yet open

Functional Development and Clinical Validation of a Diagnostic Tool Based on Artificial Intelligence for the Assessment of Sperm Quality and the Selection of the Optimal In Vitro Fertilisation (IVF) Treatment

NCT07185984Infertility (IVF Patients), Male Fertility, Sperm Selection

Instituto Valenciano de Infertilidad, IVI VALENCIA

Observational

200

Valencia

2025-11

Recruiting

A Study With CIT-013 in HS Patients

NCT06993233Hidradenitis Suppurativa (HS)

DrugsCIT-013 medium·CIT-013

Citryll BV

Phase 2

Barcelona, Madrid, Santiago de Compostela, Seville, Valencia

2025-10-31

Recruiting

ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

NCT07173751Breast Neoplasms

DrugsEribulin·Pumitamig·Gemcitabine·Carboplatin

BioNTech SE

Phase 3

558

Badajoz, Barcelona, Córdoba, Madrid, Murcia, Pamplona, Sabadell, Valencia

2025-10-30

Recruiting

A Study to Assess the Effectiveness and Safety of GSK3862995B in Adults With Bronchiectasis

NCT07201051Bronchiectasis

DrugGSK3862995B

GlaxoSmithKline

Phase 2

363

Barcelona, Lleida, Madrid, MErida Badajoz, Oviedo, Valencia

2025-10-30

Recruiting

Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)

NCT07123155Pompe Disease

Shionogi

Phase 2

Madrid, Valencia

2025-10-30

Recruiting

Effects of Carbon Fiber Insoles on CMJ and Sprint Performance

NCT07589231Healthy, Sportsman, Prevention, Performance

Benjamín Cuenca Valero

Not applicable

Valencia

2025-10-30

Recruiting

A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer

NCT07205822Breast Cancer

DrugDato-DXd

AstraZeneca

Phase 3

100

A Coruña, Barcelona, Granada, Madrid, Seville, Valencia

2025-10-30

Recruiting

A Study to Learn About Ritlecitinib for the Potential Treatment of Chronic Spontaneous Urticaria in Adults.

NCT07219615Chronic Spontaneous Urticaria

DrugsLitfulo·Ritlecitinib

Pfizer

Phase 2

200

Santiago de Compostela, Córdoba, Barcelona, Alcorcón, Valencia

2025-10-30

Recruiting

Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD

NCT06659445Geographic Atrophy (GA), Age - Related Macular Degeneration (AMD)

DrugAvacincaptad Pegol

ONL Therapeutics

Phase 2

324

Barcelona, Bilbao, Córdoba, Madrid, Seville, Valencia, Zaragoza

2025-10-28

By invitation

Clinical Trial of Vormatrigine in Adult Patients With Epilepsy

NCT07287163Epilepsy, Tonic-Clonic, Focal Seizure, Primary Generalized Seizure

Praxis Precision Medicines

Phase 3

700

Barcelona, Madrid, Málaga, Terrassa, Valencia

2025-10-27

Recruiting

A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)

NCT06405087Ulcerative Colitis, Crohn's Disease

DrugVedolizumab

Takeda

Phase 3

Ferrol, Madrid, Seville, Valencia

2025-10-27

Recruiting

Managing Chronic Spinal Pain With Exercise and Neuromodulation

NCT06969456Spinal Pain Syndrome, Chronic Pain (Back / Neck)

Fundación Universidad Católica de Valencia San Vicente Mártir

Not applicable

Valencia

2025-10-27

Recruiting

A Research Study Looking at How Different Doses of Study Medicine (Inno8) Work in the Body of People With Haemophilia A

NCT07220564Haemophilia A

Novo Nordisk A/S

Phase 1

Barcelona, Madrid, Málaga, Salamanca, Valencia

2025-10-23

Recruiting

Impact of a Physical Exercise Program in a Rural Area

NCT06842849Old Age; Debility

University of Valencia

Not applicable

140

Valencia

2025-10-22

Active, closed

Olistic_2025 for Hair Loss, Hair Growth, and Skin Improvement

NCT07300813Hair Care, Hair Loss, Female Pattern Hair Loss

Bionos Biotech S.L.

Not applicable

100

Valencia

2025-10-20

Recruiting

Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.

NCT07407465Colorectal Cancer, Colorectal Adenocarcinoma, Rectal Adenocarcinoma, Rectal Cancer, Adenocarcinoma

DrugsTrastuzumab deruxtecan·Capecitabine·Bevacizumab

Gruppo Oncologico del Nord-Ovest

Phase 2

Barcelona, Granada, Madrid, Santiago de Compostela, Valencia

2025-10-20

Recruiting

RomSi: Mobile Health Intervention to Enhance Suicide Prevention by Reducing Stigma and Increasing Literacy

NCT06759129Suicidal Ideation and Behavior, Suicide

University of Valencia

Not applicable

214

Valencia

2025-10-15

Active, closed

Clinical Evaluation of a Nutraceutical Supplement for Hair Growth, Hair Loss and Skin Improvement in Human Volunteers Versus Placebo

NCT07111299Early Female Pattern Hair Loss (FPHL)

Olistic Research Labs S.L.

Not applicable

100

Valencia

2025-10-13

Recruiting

Prospective Multicentre Study for the Application of Telomere Measurement Technology as a Tool for Lung Cancer Diagnosis

NCT07465848Lung Cancer (Diagnosis), Health Adult Subjects, Patient

Grupo Español de Investigación en Diagnóstico y Tratamiento Hipertemprano de Enfermedades (GeDiTPhe)

Not applicable

1,200

Elche, Barcelona, Santander, Madrid, Oviedo, Toledo, Valencia

2025-10-08

Recruiting

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

NCT07190248Non-small Cell Lung Cancer

Drugs) Berahyaluronidase alfa·Calderasib·Paraplatin·Pemetrexed

Merck Sharp & Dohme LLC

Phase 3

675

Badalona, Barcelona, A Coruña, Majadahonda, Valencia, Madrid, Seville

2025-10-08

Recruiting

A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

NCT07100106Breast Cancer

DrugsRGT-419B·Giredestrant·Abemaciclib

Genentech, Inc.

Phase 1/2

285

Barcelona, Madrid, Valencia

2025-10-07

Recruiting

A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease

NCT07196722Crohn Disease

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 2/3

1,092

Barcelona, Gijón, Girona, Madrid, Santiago de Compostela, Seville, Valencia

2025-10-03

Recruiting

Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronary Syndromes

NCT07102628Acute Coronary Syndrome

DrugInclisiran

Novartis Pharmaceuticals

Phase 3

300

Santiago Compostela, Huelva, El Palmar, Las Palmas GC, Madrid, Salamanca, Seville, Valencia

2025-10-03

Recruiting

Use of Vassopresin in Septic Shock Prospective Multicenter Observational Study With Medication

NCT07255378Septic Shock

Jamil Cedeño Mora

Observational

1,200

Terrassa, Getafe, Madrid, Majadahonda, Móstoles, Valencia, Zaragoza

2025-10-01

Recruiting

Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

NCT07181161Metastatic Prostate Cancer

DrugPalacaparib

AstraZeneca

Phase 1/2

283

Barcelona, L'Hospitalet de Llobregat, Madrid, Pamplona, Santander, Valencia

2025-10-01

Recruiting

HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

NCT05745714Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory

DrugsRuxolitinib·Cytarabine·Venetoclax·Dexamethasone

Princess Maxima Center for Pediatric Oncology

Phase 1/2

Barcelona, Madrid, Valencia

2025-10-01

Active, closed

A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in Europe (PLATINUM EU)

NCT07210463Neuromuscular Agents, Peripheral Nervous System Agents, Physiological Effects of Drugs, Acetylcholine Release Inhibitors

DrugXeomin

Merz Aesthetics GmbH

Phase 3

300

Pamplona, Valencia

2025-10-01

Recruiting

HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

NCT05751044Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory

DrugsDasatinib·Cytarabine·Venetoclax·Dexamethasone

Princess Maxima Center for Pediatric Oncology

Phase 1/2

Barcelona, Madrid, Valencia

2025-10-01

By invitation

A Long-Term Study of Navenibart in Participants With Hereditary Angioedema

NCT07204938Hereditary Angioedema (HAE)

DrugNavenibart

Astria Therapeutics, Inc.

Phase 3

145

Madrid, Valencia

2025-10-01

Recruiting

Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy

NCT07106762Urothelial Cancer

DrugsIza-bren·Gemcitabine·Cisplatin·Carboplatin

Bristol-Myers Squibb

Phase 2/3

470

Barcelona, Santander, Madrid, Valencia, Badajoz, Córdoba, Seville

2025-09-30

Recruiting

An Extension Trial to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy

NCT07197866Multiple System Atrophy

DrugEmrusolmin

Teva Branded Pharmaceutical Products R&D LLC

Phase 2

200

Barcelona, Madrid, Pamplona, Seville, Valencia

2025-09-30

Recruiting

Non-Pharmacological Interventions for Neurotoxicity in Hematologic Patients Receiving CAR-T Therapy

NCT07173166Hematologic Cancer

Instituto de Investigacion Sanitaria INCLIVA

Not applicable

338

Valencia

2025-09-30

Recruiting

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

NCT07028853Metastatic Castration Sensitive Prostate Cancer (mCSPC), Hormone Sensitive Prostate Cancer, Prostate Cancer, Cancer of the Prostate

DrugsMevrometostat·Xtandi·Enzalutamide

Pfizer

Phase 3

1,000

Barcelona, Madrid, Vigo, Valencia

2025-09-28

Recruiting

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

NCT07007312Acute Myeloid Leukemia (AML)

DrugsZiftomenib·Venclyxto·Ara-C·Daunorubicin

Kura Oncology, Inc.

Phase 3

1,300

Seville, Zaragoza, Burgos, Salamanca, Albacete, Madrid, Oviedo, Valencia

2025-09-26

By invitation

Difference in Incontinence Prevalence Between High Impact Athletes, Low Impact Athletes and Sedentary Subjects

NCT07710508Urinary Incontinence (UI), Urinary Incontinence , Stress

University of Valencia

Observational

270

Valencia

2025-09-24

Recruiting

A Study of PHN-012 in Patients With Advanced Solid Tumors

NCT07127874Colon Cancer, Pancreatic Cancer, Lung Cancer (NSCLC), Advanced Cancer

Pheon Therapeutics

Phase 1

165

Barcelona, Madrid, Valencia

2025-09-23

Recruiting

A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

NCT07111520Non-small Cell Lung Cancer

DrugsBNT326·Pumitamig

BioNTech SE

Phase 1/2

880

Barcelona, Córdoba, Madrid, Málaga, Pamplona, Seville, Valencia

2025-09-22

Recruiting

Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis

NCT07023835Amyotrophic Lateral Sclerosis (ALS)

Zydus Therapeutics Inc.

Phase 2

240

Alicante, Barcelona, Málaga, Valencia

2025-09-17

Recruiting

Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)

NCT07176689Desmoid Tumor, Aggressive Fibromatosis

DrugNirogacestat

SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Phase 4

Barcelona, Madrid, Valencia, Zaragoza

2025-09-17

Recruiting

Effect of Dance on the Parameters of the ICF in Children With Functional Diversity

NCT07166055Children With Disabilities

University of Valencia

Not applicable

Valencia

2025-09-15

Recruiting

A Study to Evaluate How Apitegromab Works in Subjects Who Are Less Than 2 Years Old and Have Spinal Muscular Atrophy

NCT07047144Spinal Muscular Atrophy, SMA, Spinal Muscular Atrophy Type 2, Spinal Muscular Atrophy Type 3

DrugsApitegromab·Nusinersen·Risdiplam

Scholar Rock, Inc.

Phase 2

Barcelona, Valencia

2025-09-15

Recruiting

Using Advanced CT Scans and Blood Markers to Better Understand Heart Damage and Recovery After a Heart Attack

NCT07268391Acute Myocardial Infarction (AMI)

Instituto de Investigación Biomédica de Salamanca

Not applicable

Madrid, Salamanca, Valencia

2025-09-15

Recruiting

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

NCT06926868Breast Neoplasms

DrugsIza-bren·Nab-paclitaxel·Capecitabine·Gemcitabine

Bristol-Myers Squibb

Phase 2/3

600

A Coruña, Elche, Barcelona, Hospitalet, Donostia / San Sebastian, Madrid, Málaga, Valencia

2025-09-11

Recruiting

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

NCT07054190Breast Cancer

DrugsGiredestrant·Inavolisib·Ribociclib·Letrozole

Hoffmann-La Roche

Phase 2

120

Barcelona, Madrid, Salamanca, Seville, Valencia

2025-09-09

Recruiting

A Study of Navlimetostat (BMS-986504) Alone or in Combination With Izalontamab Brengitecan in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion or MTAP Loss (MountainTAP-9)

NCT06855771Carcinoma, Non-Small-Cell Lung

DrugsNavlimetostat·Iza-bren

Bristol-Myers Squibb

Phase 2

182

Barcelona, Hospitalet, Madrid, Málaga, Seville, Valencia

2025-09-09

Recruiting

A Real World Study to Globally Assess Disease Burden in Adolescent and Adult Participants With Alopecia Areata, Vitiligo, or Hidradenitis Suppurativa

NCT07136467Non-Segmental Vitiligo (NSV), Alopecia Areata, Hidradenitis Suppurativa

AbbVie

Observational

2,795

Jaén, Alcorcón, Majadahonda, Parla, San Cristóbal de La Laguna, Valencia

2025-09-02

Not yet open

A Study to Evaluate the Clinical Benefit and Safety of Medical Compression Garments in the Management of Patients With Lipedema

NCT07125092Lipoedema

Thuasne

Not applicable

Valencia

2025-09-01

Not yet open

The SUNRISE Project is Dedicated to Enhancing Primary Cancer Prevention Among Adolescents in Europe by Leveraging Innovative Digital Tools and Methodologies. SmartCoach, Developed by Swiss Research Institute for Public Health and Addiction (ISGF), is a Mobile Phone-based Life-skills Training Program

NCT06922201Cancer

Biobizkaia Health Research Institute

Not applicable

3,500

Valencia

2025-09

Not yet open

Effects of Gait Rehabilitation With Motor Imagery in People With Parkinson's Disease

NCT04788693Parkinson Disease

University of Valencia

Not applicable

Valencia

2025-09

Not yet open

SUNRISE Aims to Create a Comprehensive, Engaging, and Sustainable Digital Health Promotion Program That Not Only Addresses Immediate Health Behaviours But Also Instils Lifelong Healthy Habits Among Adolescents. It is a Unique, Digitally Enhanced Program Combining Different Digital Solutions With New

NCT06931847Cancer

Biobizkaia Health Research Institute

Observational

4,000

Valencia

2025-09

Recruiting

A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

NCT07043400Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

DrugsLeucovorin·Adrucil·Tislelizumab·Capecitabine

BeOne Medicines

Phase 3

351

Barcelona, Pamplona, Valencia, Zaragoza

2025-08-27

Recruiting

A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors

NCT07169734Cervical Squamous Cell Carcinoma, Squamous Non-small-cell Lung Cancer, Colorectal Cancer, Intrahepatic Cholangiocarcinoma

Alentis Therapeutics AG

Phase 1/2

180

Barcelona, Córdoba, El Palmar, Madrid, Seville, Tarragona, Valencia

2025-08-26

Recruiting

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine

NCT07018700Episodic Migraine

DrugXeomin

Merz Therapeutics GmbH

Phase 3

990

Barcelona, Madrid, Málaga, Seville, Terrassa, Valencia, Vigo, Zaragoza

2025-08-21

Recruiting

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

NCT07018713Chronic Migraine

DrugXeomin

Merz Therapeutics GmbH

Phase 3

780

Barcelona, Madrid, Málaga, Seville, Terrassa, Valencia, Vigo, Zaragoza

2025-08-21

Recruiting

AGENT DCB STANCE: Safety and Effectiveness Study of AGENT Drug-Coated Balloon Compared to Standard of Care Percutaneous Coronary Intervention (PCI) Treatment for de Novo Coronary Lesions

NCT06959524Coronary Arterial Disease (CAD), de Novo Lesions in Native Coronary Arteries

Boston Scientific Corporation

Not applicable

1,616

Madrid, Valencia, Valladolid

2025-08-21

Active, closed

A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

NCT07005128Small-cell Lung Cancer, Extensive Stage Small-cell Lung Cancer

DrugsTarlatamab·Etoposide·Durvalumab·Carboplatin

Amgen

Phase 3

350

Málaga, Barcelona, Majadahonda, Valencia, Madrid

2025-08-18

Recruiting

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

NCT07070232Advanced Solid Tumor

DrugsBNT326·Paroxetine·Itraconazole·Pumitamig

BioNTech SE

Phase 1/2

1,438

Barcelona, Logroño, Madrid, Pozuelo de Alarcón, Valencia

2025-08-12

Recruiting

A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

NCT07098338Non-Small Cell Lung Cancer

DrugsRamucirumab·Rilvegostomig·Dato-DXd

AstraZeneca

Phase 2

278

A Coruña, Madrid, Manresa, Málaga, Santander, Valencia

2025-08-07

Recruiting

A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

NCT07094516Alzheimer's Disease

DrugVHB937

Novartis Pharmaceuticals

Phase 2

407

Pamplona, Valencia

2025-08-07

Recruiting

A Phase 3 Single-arm Study of UGN-104 for the Treatment of Low-grade Upper Tract Urothelial Cancer

NCT06774131Upper Urinary Tract Urothelial Carcinoma, Urothelial Carcinoma

UroGen Pharma Ltd.

Phase 3

Barcelona, A Coruña, Madrid, Cadiz, Córdoba, Murcia, Seville, Valencia

2025-08-06

Recruiting

Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO)

NCT06709339Polypoidal Choroidal Vasculopathy

DrugsVabysmo·Faricimab

Association for Innovation and Biomedical Research on Light and Image

Phase 4

120

Barcelona, Madrid, Oviedo, Valencia

2025-08-06

Recruiting

Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy

NCT07075016Acute Myeloid Leukemia

Stichting Hemato-Oncologie voor Volwassenen Nederland

Phase 3

227

Barcelona, Girona, Valencia

2025-08-05

Active, closed

A Study to Evaluate Tobevibart+Elebsiran Versus Bulevirtide in Chronic HDV Infection

NCT07142811Viral Hepatitis

DrugsTobevibart·Elebsiran·Bulevirtide

Vir Biotechnology, Inc.

Phase 2

100

Barcelona, Madrid, Valencia

2025-08-05

Recruiting

A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis

NCT07100119ALS (Amyotrophic Lateral Sclerosis)

DrugLY4256984

Eli Lilly and Company

Phase 1

L'Hospitalet de Llobregat, Valencia

2025-08-05

Recruiting

Obe-cel in Refractory Progressive Forms of Multiple Sclerosis

NCT07139743Progressive Multiple Sclerosis

DrugObecabtagene autoleucel

Autolus Limited

Phase 1

Barcelona, Valencia

2025-08-04

Recruiting

A Study to Assess Adverse Events, Change in Disease Activity of Intravenous Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Adult Participants With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

NCT07005102Non-Squamous Non-Small Cell Lung Cancer, c-MET

DrugsTelisotuzumab Adizutecan·Osimertinib·Pemetrexed·Cisplatin

AbbVie

Phase 2/3

854

Barcelona, Madrid, Valencia

2025-08-03

Recruiting

Permanent Conduction System Pacing Versus Atrioventricular Management for Patients With Wide QRS and Patent AV Conduction

NCT07585799Bradycardia

Óscar Cano Pérez

Not applicable

120

Granada, Zaragoza, Valencia

2025-07-29

Recruiting

A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)

NCT06911502Follicular Lymphoma

DrugsPrednisone/Prednisolone·Golcadomide·Bendamustine·Vincristine

Celgene

Phase 3

400

Sabadell, Santander, Madrid, Valencia, Granada

2025-07-28

Recruiting

Phase 2/3 Study of Participants With Recurrent Pericarditis Evaluating the Efficacy and Safety of KPL-387

NCT07010159Pericarditis, Pericarditis Acute, Recurrent Pericarditis

DrugKPL-387

Kiniksa Pharmaceuticals International, plc

Phase 2/3

325

Barcelona, Madrid, Murcia, Valencia

2025-07-25

Recruiting

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

NCT06758401Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC)

DrugsSigvotatug vedotin·Pembrolizumab

Pfizer

Phase 3

714

A Coruña, Elche, Barcelona, L'Hospitalet de Llobregat, Jerez de la Frontera, Palma, Madrid, Valencia

2025-07-23

Recruiting

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

NCT06943755Pancreatic Neuroendocrine Tumor (pNET), Extra-Pancreatic Neuroendocrine Tumor (epNET)

DrugsZanzalintinib·Everolimus

Exelixis

Phase 2/3

440

Barcelona, Madrid, Murcia, Oviedo, Santander, Santiago de Compostela, Seville, Valencia

2025-07-21

Recruiting

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

NCT06976203Alzheimer's Disease

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

586

Barcelona, Donostia / San Sebastian, Santander, Pozuelo de Alarcón, Valencia, Madrid

2025-07-21

Recruiting

Neoadjuvant Tebentafusp in Patients With Metastatic Uveal Melanoma

NCT07057596Mestastatic Uveal Melanoma

DrugTebentafusp

Grupo Español Multidisciplinar de Melanoma

Phase 2

L'Hospitalet de Llobregat, Madrid, Valencia

2025-07-18

Recruiting

Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis

NCT06950385Familial Adenomatous Polyposis (FAP)

DrugERapa

Rapamycin Holdings Inc.

Phase 3

168

Barcelona, Inca, Madrid, Valencia

2025-07-18

Recruiting

A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma

NCT07069712Gastroesophageal Adenocarcinoma

DrugsSonesitatug Vedotin·Calcium folinate·Rilvegostomig·Trastuzumab deruxtecan

AstraZeneca

Phase 2

100

Barcelona, Elche, Madrid, Málaga, Ourense, Oviedo, Santander, Valencia

2025-07-17

Recruiting

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

NCT06997497Colon Adenocarcinoma, Rectal Adenocarcinoma

DrugsBevacizumab biosimilar·Calderasib·Mvasi·Erbitux

Merck Sharp & Dohme LLC

Phase 3

477

Badalona, Santander, Las Palmas de Gran Canaria, Oviedo, Barcelona, Madrid, Seville, Valencia

2025-07-16

Recruiting

Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

NCT06898515Acute Decompensated Heart Failure

DrugFurosemide

Reprieve Cardiovascular, Inc

Phase 3

400

Barcelona, Madrid, Valencia

2025-07-14

Active, closed

A Study to Investigate the Use of VH3810109 With or Without Fostemsavir (FTR) to Reduce the Size and Activity of the Viral Reservoir in People Living With HIV

NCT07053384HIV Infections

DrugsVH3810109·Fostemsavir

ViiV Healthcare

Phase 1

107

Pozuelo de Alarcón, Barcelona, Córdoba, La Laguna Santa Cruz, Madrid, Palma de Mallorca, Seville, Valencia

2025-07-10

Recruiting

Usefulness of Corifollitropin α as Alternative to Conventional Daily rFSH Protocols in Oocyte Donors Undergoing Pituitary Suppression With Medroxiprogesterona Acetate (MPA)

NCT06193135Infertility, Female, Reproductive Sterility

DrugsElonva·Puregon

Instituto Valenciano de Infertilidad, IVI VALENCIA

Not applicable

318

Valencia

2025-07-08

Recruiting

Study of Abnormally Fertilized Embryos

NCT06940973Infertility (IVF Patients)

Igenomix

Observational

300

Valencia

2025-07-02

Active, closed

Comparative Clinical Study of Conventional vs Customized Healing Abutments in Dental Implantology

NCT07031232Peri-implant Soft Tissue Healing, Soft Tissue Management in Subcrestal Dental Implants, Healing Abutment Influence on Gingival Volume

University of Valencia

Not applicable

Valencia

2025-07-01

Recruiting

Single-Fraction Very Accelerated Partial Breast Irradiation (sfVAPBI)

NCT07067437Breast Neoplasms

National Institute of Oncology, Hungary

Not applicable

250

Barcelona, Pamplona, Valencia

2025-07-01

Recruiting

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

NCT06966700Breast Neoplasms, Triple Negative Breast Neoplasms, HR Low-Positive/HER2-Negative Breast Neoplasms

DrugsEpirubicin·Adriamycin·Xeloda·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

2,400

L'Hospitalet de Llobregat, Bilbao, Salamanca, Jaén, Santiago de Compostela, Pozuelo de Alarcón, Valencia, Barcelona

2025-06-30

Active, closed

A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer

NCT06966453Breast Cancer, Breast Neoplasms

DrugDisitamab Vedotin

Pfizer

Phase 1/2

Barcelona, Madrid, Málaga, Valencia, Granada

2025-06-30

Active, closed

Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic Disease Activity

NCT06979531Primary Sjögren's Syndrome

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 2

180

Bilbao, Cadiz, Córdoba, Mérida, Valencia

2025-06-30

Active, closed

Rezafungin for Treatment of Chronic Pulmonary Aspergillosis (CPA) in Adults With Limited Treatment Options

NCT06794554Chronic Pulmonary Aspergillosis

Mundipharma Research Limited

Phase 2

Barcelona, Madrid, Martorell, Valencia

2025-06-30

Recruiting

A Phase 1b/2a Study of Budoprutug in Subjects With Immune Thrombocytopenia (ITP)

NCT07043946Immune Thrombocytopenia (ITP), ITP, Biologics, Monoclonal

DrugBudoprutug

Climb Bio, Inc.

Phase 1/2

Burgos, Madrid, San Pedro, Valencia

2025-06-30

Recruiting

A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

NCT06979362Heart Failure

DrugCDR132L

Novo Nordisk A/S

Phase 2

200

Granada, El Palmar, Barcelona, Las Palmas de Gran Canaria, Madrid, Valencia

2025-06-27

Recruiting

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

NCT06937099Crohn's Disease, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

290

Barcelona, Ferrol, Gijón, Madrid, Oviedo, Pamplona, Seville, Valencia

2025-06-26

Recruiting

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

NCT06937086Ulcerative Colitis, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

350

Barcelona, Ferrol, Gijón, Madrid, Oviedo, Pamplona, Seville, Valencia

2025-06-26

Recruiting

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

NCT06846281Relapsing Multiple Sclerosis

DrugsRemibrutinib·Ocrelizumab

Novartis Pharmaceuticals

Phase 3

400

El Palmar, Valencia, Barcelona, Córdoba, Madrid, Málaga, Seville

2025-06-23

Recruiting

A Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease

NCT07239570Chronic Kidney Disease(CKD)

DrugsFinerenone·Semaglutide·Dapagliflozin

Peter Rossing

Phase 4

125

Valencia

2025-06-20

Recruiting

A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

NCT06972446Rheumatoid Arthritis

DrugsABBV-8736·ABBV-701·Lutikizumab·Adalimumab

AbbVie

Phase 2

180

Sabadell, Seville, Bilbao, A Coruña, Córdoba, Madrid, Valencia

2025-06-20

Recruiting

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

NCT06991257Heart Failure

DrugPF-07328948

Pfizer

Phase 2

620

Santiago de Compostela, Barcelona, L'Hospitalet de Llobregat, Majadahonda, Madrid, Valencia

2025-06-19

Recruiting

SHort Of Pace - Heart Failure (SHOP-HF)

NCT06992089Heart Failure With Preserved Ejection Fraction

Fundación para la Investigación del Hospital Clínico de Valencia

Not applicable

Valencia

2025-06-17

Recruiting

Randomized Interval Assessment Trial of Lu177-Dotatate in Slowly Progressive G1-2 Advanced Midgut Neuroendocrine Tumors

NCT06878664Grade1-2 Advanced Midgut Neuroendocrine Tumors (NETs)

DrugsAmino acid·Lanreotide·Octreotide LAR·Lutathera

Grupo Espanol de Tumores Neuroendocrinos

Phase 3

166

Barcelona, L'Hospitalet de Llobregat, Burgos, Granada, Madrid, Oviedo, Seville, Valencia

2025-06-12

Recruiting

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

NCT06340568Endometrial Cancer

DrugsDoxorubicin·Docetaxel·Paclitaxel

BioNTech SE

Phase 3

480

Barcelona, Córdoba, Donostia / San Sebastian, Girona, Madrid, Valencia

2025-06-10

Recruiting

A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

NCT07038200Facioscapulohumeral Muscular Dystrophy, FSHD, FSHD - Facioscapulohumeral Muscular Dystrophy, FSHD1

DrugDel-brax

Avidity Biosciences, Inc.

Phase 3

200

Barcelona, San Sebastián, Valencia

2025-06-10

Active, closed

PLUG-IN: Pembrolizumab Combined With Enfortumab Vedotin for Advanced Melanoma Patients

NCT06906822Melanoma

DrugsEnfortumab Vedotin·Pembrolizumab

Grupo Español Multidisciplinar de Melanoma

Phase 2

A Coruña, Badalona, Barcelona, Santander, Madrid, Murcia, Seville, Valencia

2025-06-10

Recruiting

ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

NCT06902558Autosomal Dominant Polycystic Kidney Disease

Calico Life Sciences LLC

Phase 2

240

Barcelona, L'Hospitalet de Llobregat, Granada, Madrid, Seville, Valencia

2025-06-09

Recruiting

A Study of Momelotinib in Participants With Low-risk Myelodysplastic Syndrome

NCT06847867Myelodysplastic Syndromes

DrugMomelotinib

GlaxoSmithKline

Phase 2

Barcelona, Madrid, Málaga, Ourense, PamplonaNavarra, Salamanca, Valencia

2025-06-05

Not yet open

Clinical Trial to Evaluate Three Systems of Osteosynthesis for Fixation of Olecranon Osteotomies in Adults

NCT07014358Olecranon Fracture

Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal

Phase 4

105

Santander, Madrid, Valencia

2025-06

Recruiting

Comparison of the Perception of Non-technical Skills

NCT06340529Healthy

University of Valencia

Not applicable

100

Valencia

2025-05-30

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity in Participants With Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression Treated With Intravenously (IV) Infused Mirvetuximab Soravtansine

NCT06682988Advanced High-Grade Epithelial Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancers

DrugsMIRV·Mirvetuximab Soravtansine

AbbVie

Phase 2

110

Badalona, Jaén, El Palmar, Pamplona, Seville, Barcelona, Madrid, Valencia

2025-05-28

Recruiting

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

NCT06952504Endometrial Cancer

DrugsSacituzumab tirumotecan·Docetaxel·Keytruda·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

1,123

L'Hospitalet de Llobregat, Girona, Barcelona, Córdoba, Madrid, Valencia

2025-05-22

Recruiting

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

NCT06935370Heart Failure

DrugsVicadrostat·Dapagliflozin

Boehringer Ingelheim

Phase 3

4,200

Barcelona, Madrid, Sanlúcar de Barrameda, Torrejón de Ardoz, Valencia, Villamartín

2025-05-20

Recruiting

Exercise to Fight Obesity

NCT06934681Morbid Obesity, Bariatric Surgery, Telerehabilitation

Instituto de Investigacion Sanitaria La Fe

Not applicable

Valencia

2025-05-19

Recruiting

Optimizing Reperfusion to Improve Outcomes and Neurologic Function

NCT06990867Acute Ischemic Stroke

Corxel Pharmaceuticals

Phase 2/3

740

A Coruña, Albacete, Barcelona, Girona, Madrid, Málaga, Seville, Valencia

2025-05-15

Recruiting

Spontaneous Eye Blinking in Disorders of Consciousness

NCT06323031Disorders of Consciousness

Fondazione Don Carlo Gnocchi ETS

Observational

Valencia

2025-05-08

Recruiting

Safety of HRX215 in Patients After Minor and Major Liver Resection

NCT06638502Liver Resection, Colorectal Carcinoma Liver Metastases

HepaRegeniX GmbH

Phase 1/2

Madrid, Valencia

2025-05-06

Recruiting

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

NCT06499285Myelodysplastic Syndromes

DrugElritercept

Takeda

Phase 3

225

Salamanca, Barcelona, L'Hospitalet de Llobregat, Madrid, Valencia

2025-05-06

Recruiting

A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

NCT06747351Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

DrugsTAK-881·Phesgo

Takeda

Phase 3

Barcelona, Valencia

2025-05-06

Recruiting

Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML

NCT06652438Acute Myeloid Leukemia, Adult

DrugRevumenib

Stichting Hemato-Oncologie voor Volwassenen Nederland

Phase 3

448

Alicante, Barcelona, Girona, Lleida, Madrid, Palma de Mallorca, Tarragona, Valencia

2025-05-05

Recruiting

Effectiveness of an IVR-based Therapeutic Exercise Program With Altered Visual Feedback in Fibromyalgia Patients

NCT06948500Fibromyalgia

Cardenal Herrera University

Not applicable

Valencia

2025-05-05

Recruiting

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

NCT06892548Advanced Lung Cancer

DrugsBNT324·Pumitamig

BioNTech SE

Phase 1/2

594

Barcelona, Córdoba, Málaga, Seville, Torrejón de Ardoz, Valencia

2025-05-02

Recruiting

NESA Neuromodulation Versus Transcutaneous Posterior Tibial Stimulation

NCT07019597Bladder Dysfunction

Daniel David Álamo Arce

Not applicable

Valencia

2025-05-01

Active, closed

Pediatric Expansion Study of the Sentio System

NCT06976086Hearing Loss, Conductive, Hearing Loss, Mixed, Single Sided Deafness

Oticon Medical

Not applicable

San Sebastián, Seville, Valencia

2025-04-30

Active, closed

Long-term Safety and Efficacy of Leniolisib in PIDs With Immune Dysregulation

NCT06990529PIDs Linked to PI3K

DrugLeniolisib

Pharming Technologies B.V.

Phase 2

Valencia

2025-04-29

By invitation

A Study of Long-term Safety and Efficacy of VX-670 in Participants With Myotonic Dystrophy Type I

NCT06926621Myotonic Dystrophy Type 1 (DM1)

DrugVX-670

Vertex Pharmaceuticals Incorporated

Phase 2

Valencia

2025-04-28

Recruiting

Eganelisib as Monotherapy and in Combination With Cytarabine in Relapsed/Refractory AML

NCT06533761AML, Adult, MDS

DrugCytarabine

Stelexis BioSciences

Phase 1

125

Cáceres, Valencia

2025-04-28

Recruiting

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

NCT06820463Metastatic Colorectal Cancer

DrugsTelisotuzumab Adizutecan·Panitumumab·Fluorouracil·Leucovorin

AbbVie

Phase 2

390

Santander, Pamplona, Barcelona, Madrid, Valencia

2025-04-24

Active, closed

A Study of Roginolisib (IOA-244) in Combination With Dostarlimab With or Without Docetaxel in Metastatic Non Small-cell Lung Cancer (NSCLC) Patients

NCT06879717Non-Squamous Non-Small Cell Lung Cancer (NSCLC), Advanced Non Squamous NSCLC

DrugsRoginolisib·Dostarlimab·Docetaxel

iOnctura

Phase 1/2

Barcelona, Palma, Valencia

2025-04-22

Recruiting

MELIORA Data Collection Campaigns

NCT07190066Breast Cancer Prevention

Harokopio University

Not applicable

300

Valencia

2025-04-22

Recruiting

EMBRACE Tremor BiFUS

NCT06974916Essential Tremor

InSightec

Not applicable

100

Badalona, Móstoles, Pamplona, Valencia

2025-04-22

Recruiting

A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)

NCT06843447Ovarian Cancer Recurrent

DrugsMK-2010·R-DXd·Zirabev·Pegylated liposomal doxorubicin

Merck Sharp & Dohme LLC

Phase 1/2

605

L'Hospitalet de Llobregat, Majadhonda, Madrid, Valencia, Barcelona, Málaga

2025-04-15

Recruiting

Therapeutic Potential of a Synbiotic to Improve Mental Health in Subjects With Obesity.

NCT06901739Obese Patients (BMI ≥ 30 kg/m²), Anxiety, Depressive Disorder

Celia Bañuls

Not applicable

120

Valencia

2025-04-15

Recruiting

Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors

NCT06795412Advanced Solid Tumors

DrugsPYX-201·Keytruda·Pembrolizumab

Pyxis Oncology, Inc

Phase 1/2

220

Barcelona, Madrid, Valencia

2025-04-15

Recruiting

Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers

NCT06906341Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Neoplasms, Endometrial Cancer

DrugsNab-paclitaxel /m^2·Relacorilant·Bevacizumab

Corcept Therapeutics

Phase 2

270

Badalona, Barcelona, Madrid, Valencia

2025-04-11

Active, closed

ASCEND CSP IDE Study

NCT06830746Heart Failure, Ventricular Arrythmia

Abbott Medical Devices

Not applicable

414

Granada, Valencia

2025-04-11

Recruiting

A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)

NCT06824467Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer

DrugsSteroid mouthwash (dexamethasone·Mvasi·Acetaminophen·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

770

Girona, Madrid, Valencia, Barcelona, Córdoba

2025-04-09

Active, closed

Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

NCT06822790Hypertriglyceridemia

DrugPlozasiran

Arrowhead Pharmaceuticals

Phase 3

710

A Coruña, Barcelona, Madrid, Santiago de Compostela, Seville, Valencia, Zaragoza

2025-04-09

Recruiting

Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis

NCT06408259Multiple Sclerosis, Relapsing-Remitting

DrugsFingolimod·Ozanimod

Bristol-Myers Squibb

Phase 3

194

Esplugues de Llobregat, Vigo, Seville, Valencia, Zaragoza

2025-04-08

Active, closed

A Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy (DMD)

NCT06450639Duchenne Muscular Dystrophy

DrugSatralizumab

Hoffmann-La Roche

Phase 2

Esplugues de Llobregas, Asturias, Almería, Valencia

2025-04-04

Recruiting

BOne Metastases REgistry for Patients Undergoing cryoAbLation With curatIve purpoSe

NCT06480955Bone Metastases

Cardiovascular and Interventional Radiological Society of Europe

Observational

Valencia

2025-04-01

Recruiting

Home-based Graded Repetitive Arm Supplementary Program for Quality of Life and Functional Upper Limb Recovery

NCT07146789Stroke With Hemiparesis

Universidad Miguel Hernandez de Elche

Not applicable

Valencia

2025-04-01

By invitation

Long-term Safety and Efficacy Study of Riliprubart in Participants With CIDP

NCT06859099Polyneuropathy, Inflammatory Demyelinating, Chronic

DrugRiliprubart

Sanofi

Phase 3

300

Barcelona, Majadahonda, Pamplona, Málaga, Valencia

2025-04-01

Not yet open

Effects of a Prehabilitation Program in Patients Undergoing Lumbar Radiculopathy Surgery

NCT06145620Lumbar Radiculopathy

Cardenal Herrera University

Not applicable

100

Valencia

2025-04

Recruiting

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

NCT06989112Endometrial Cancer

DrugsRilvegostomig·Taxotere·Paraplatin·Trastuzumab deruxtecan

AstraZeneca

Phase 3

600

A Coruña, Córdoba, Donostia / San Sebastian, El Palmar, L'Hospitalet de Llobregat, Madrid, Palma de Mallorca, Valencia

2025-03-27

Recruiting

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

NCT06914128MTAP-deleted Solid Tumors

Bayer

Phase 1/2

450

Barcelona, Logroño, Madrid, Pozuelo de Alarcón, Málaga, Valencia, Pamplona

2025-03-21

Active, closed

A Study of Navenibart in Participants With Hereditary Angioedema

NCT06842823Hereditary Angioedema (HAE)

DrugNavenibart

Astria Therapeutics, Inc.

Phase 3

157

Barcelona, Madrid, Santa Cruz de Tenerife, Seville, Valencia

2025-03-20

Recruiting

Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT07032662Chronic Inflammatory Demyelinating Polyneuropathy

Immunovant Sciences GmbH

Phase 2

162

Barcelona, Bilbao, Córdoba, Santiago de Compostela, Valencia

2025-03-18

Recruiting

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

NCT06819878Moderately to Severely Active Crohns Disease

DrugAfimkibart

Hoffmann-La Roche

Phase 3

600

Santander, Galdacao, Madrid, Murcia, Valencia, Valladolid

2025-03-17

Recruiting

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

NCT06841354Triple Negative Breast Neoplasms

DrugsAbraxane·Sacituzumab tirumotecan·Paraplatin·Taxol

Merck Sharp & Dohme LLC

Phase 3

1,000

Seville, L'Hospitalet de Llobregat, Madrid, Valencia, Barcelona

2025-03-16

Recruiting

A Study to Evaluate the Drug Levels, Efficacy, and Safety of Deucravacitinib (BMS-986165) in Pediatric Participants With Juvenile Psoriatic Arthritis

NCT06869551Juvenile Psoriatic Arthritis

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

Barcelona, Madrid, Valencia

2025-03-13

Recruiting

Advanced Invasive Diagnosis Strategy for Post-PCI Patients With Stable Coronary Syndromes Undergoing Coronary Angiography

NCT07638137Angina (Stable), Percutaneous Coronary Intervention (PCI), INOCA (Ischemia With Non Obstructive Coronary Artery Disease), Chronic Coronary Syndrome

Fundacion Investigacion Interhospitalaria Cardiovascular

Observational

246

Leganés, Madrid, Valencia

2025-03-12

Recruiting

L-Annamycin for Injection in Combination With Cytarabine Injection as Second Line Therapy for Remission Induction in Adult Subjects With Refractory/Relapsed AML

NCT06788756Acute Myeloid Leukaemia (AML)

DrugCytarabine

Moleculin Biotech, Inc.

Phase 2/3

312

Barcelona, Oviedo, Madrid, Valencia

2025-03-12

Recruiting

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

NCT06792695Metastatic Colorectal Cancer

DrugsFOLFIRI (Fluorouracil (5-FU), leucovorin, irinotecan)·Volrustomig·Bevacizumab

AstraZeneca

Phase 2

Barcelona, Madrid, Málaga, Pamplona, Santander, Valencia

2025-03-12

Recruiting

An Open-label Study to Evaluate the Pharmacokinetics and Safety of Bimekizumab in Pediatric Study Participants With Active Juvenile Idiopathic Arthritis Subtypes Enthesitis-related Arthritis (Including Juvenile-onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis

NCT06668181Enthesitis-related Arthritis, Juvenile Psoriatic Arthritis

DrugBimekizumab

UCB Biopharma SRL

Phase 3

Esplugues de Llobregat, Madrid, Valencia

2025-03-11

Recruiting

Alleviant ALLAY-HFrEF Study

NCT06812533Heart Failure

Alleviant Medical, Inc.

Not applicable

350

A Coruña, Barcelona, Madrid, Salamanca, Valencia

2025-03-10

Active, closed

A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

NCT06521567Melanoma, Hodgkin Lymphoma, High and Low Grade Glioma, Glioblastoma Multiforme (GBM)

DrugsCobolimab·Dostarlimab

GlaxoSmithKline

Phase 1/2

Barcelona, Madrid, Valencia

2025-03-06

Recruiting

Effect of Neuromodulation and Therapeutic Exercise in Urinary Incontinence

NCT06783374Urge Urinary Incontinence, Overactive Bladder (OAB)

Fundación Universidad Católica de Valencia San Vicente Mártir

Not applicable

Valencia

2025-03-04

Recruiting

A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)

NCT06796907Tumours, Gynecological

DrugsMo-Rez·Dostarlimab·Bevacizumab

GlaxoSmithKline

Phase 1/2

305

A Coruña, Barcelona, Madrid, Málaga, Valencia, Zaragoza

2025-03-04

Recruiting

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

NCT06671483Psoriatic Arthritis

DrugZasocitinib

Takeda

Phase 3

1,088

Mérida, Sabadell, Santiago de Compostela, Málaga, Seville, Valencia

2025-03-03

Recruiting

Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy as First-line or Second-line Treatment

NCT06841055Non-small Cell Lung Cancer

DrugsPumitamig·Docetaxel

BioNTech SE

Phase 2

Barcelona, Madrid, Seville, Valencia

2025-03-03

Recruiting

A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

NCT06764875HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma

DrugsRilvegostomig·Trastuzumab deruxtecan·Trastuzumab·Adrucil

AstraZeneca

Phase 3

840

Badalona, Barcelona, Madrid, Ourense, Santander, Seville, Valencia

2025-03-01

Recruiting

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis

NCT06517875Primary Myelofibrosis, Myelofibrosis; Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis

DrugsMomelotinib·Reblozyl·Luspatercept

GlaxoSmithKline

Phase 2

Badalona, Barcelona, Las Palmas, Madrid, Málaga, Valencia

2025-02-28

Active, closed

A Randomised Phase II Study of Roginolisib in Patients With Advanced/Metastatic Uveal Melanoma

NCT06717126Uveal Melanoma, Ocular Melanoma

DrugRoginolisib

iOnctura

Phase 2

Barcelona, Madrid, Santiago de Compostela, Seville, Valencia

2025-02-27

Recruiting

IMPACT-AML: A Randomized Pragmatic Clinical Trial for Relapsed or Refractory Acute Myeloid Leukemia.

NCT06713837Acute Myeloid Leukemia, Relapse/Recurrence

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

Phase 3

339

Albacete, Alicante, Barcelona, Valencia

2025-02-27

Recruiting

A Study to Compare the Efficacy and Safety of BMS-986489 (Atigotatug+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

NCT06646276Extensive-Stage Small Cell Lung Cancer

DrugsEtoposide·Atezolizumab·Nivolumab·Carboplatin

Bristol-Myers Squibb

Phase 3

530

Santiago de Compostela, Barcelona, Jaén, Madrid, Majadahonda, Valencia, Seville

2025-02-25

Active, closed

An Open-label Study to Assess the Safety, Efficacy, and Cellular Kinetics of YTB323 in Relapsing Multiple Sclerosis

NCT06617793Relapsing Multiple Sclerosis

DrugRapcabtagene autoleucel

Novartis Pharmaceuticals

Phase 1/2

Barcelona, Córdoba, Madrid, Valencia

2025-02-24

Recruiting

A Study of Neoadjuvant Dostarlimab Plus Capecitabine Plus Oxaliplatin (CAPEOX) Vs CAPEOX With Previously Untreated T4N0 or Stage III Mismatch Repair Proficient (MMRp)/Microsatellite Stable (MSS) Colon Cancer

NCT06567782Neoplasms, Colon

DrugsCapeox·Dostarlimab

GlaxoSmithKline

Phase 2

120

Barcelona, Madrid, Oviedo, Valencia

2025-02-18

By invitation

A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)

NCT06908226Developmental and Epileptic Encephalopathy

DrugBexicaserin

Longboard Pharmaceuticals

Phase 3

324

Esplugues de Llobregat, Pamplona, Barcelona, Madrid, Málaga, Valencia

2025-02-12

Active, closed

Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer

NCT06619236Platinum-resistant Ovarian Cancer

DrugsRina-S·Pegylated liposomal doxorubicin·Topotecan·Gemcitabine

Genmab

Phase 3

584

A Coruña, Donostia / San Sebastian, El Palmar, Madrid, Seville, Valencia, Zaragoza

2025-02-07

Active, closed

A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis

NCT06744920Generalized Myasthenia Gravis

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

180

Barcelona, Lleida, Madrid, Málaga, Valencia

2025-02-07

Recruiting

SMASH: Study to Evaluate the Clinical Efficacy of an Extensively Hydrolysed Infant Formula With Synbiotics and a Human Milk Oligosaccharide (HMO) in Infants With Cow's Milk Protein Allergy (CMPA)

NCT07342621Cow's Milk Protein Allergy (CMPA), Food Hypersensitivity, Infant Nutrition Disorders, Gut Microbiota

Outcomes'10

Observational

Valencia

2025-02-07

Recruiting

LEOPARD Training and Validation Data Collection Study

NCT06675604Decompensated Liver Cirrhosis, Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Hepato-cellular Carcinoma

Assistance Publique - Hôpitaux de Paris

Observational

4,500

Murcia, Seville, Valencia

2025-02-04

Recruiting

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

NCT06618287Lung Cancer, Breast Cancer

DrugsPumitamig·Iza-bren·Osimertinib·Opdivo

Bristol-Myers Squibb

Phase 1/2

416

Santiago de Compostela, Barcelona, Hospitalet, Madrid, Majadahonda, Valencia, Málaga, Seville

2025-02-04

Recruiting

Effects of a Multidisciplinary Intervention on Fall Risk and Urinary Incontinence in Older Women

NCT06839040Urinary Incontinence, Frailty, Balance Impairment

Fundación Universidad Católica de Valencia San Vicente Mártir

Not applicable

120

Valencia

2025-02-03

Recruiting

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

NCT06556563Glioblastoma

DrugsTemozolomide·Keytruda·Pembrolizumab

NovoCure GmbH

Phase 3

741

Madrid, Barcelona, Córdoba, Granada, Seville, Valencia

2025-02-03

Recruiting

Resistance Exercise in Patients With Ocular Melanoma

NCT06970236Ocular Melanoma

University of Valencia

Not applicable

Valencia

2025-02-01

Recruiting

Effects of Functional Exercise Program With Strength Load and Resistance in Children and Adolescents With Cerebral Palsy

NCT06820398Cerebral Palsy

University of Valencia

Not applicable

Valencia

2025-01-31

Active, closed

A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa (RECHARGE 1)

NCT06799000Hidradenitis Suppurativa

DrugRemibrutinib

Novartis Pharmaceuticals

Phase 3

588

Cadiz, Badalona, Sabadell, Barcelona, Manises, Valencia, Madrid

2025-01-31

Recruiting

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

NCT06564038Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma, Mantle-cell Lymphoma, Large B-cell Lymphoma

DrugsSurovatamig·Acalabrutinib·Vincristine·Doxorubicin

AstraZeneca

Phase 1/2

408

Barcelona, Madrid, Palma de Mallorca, Santiago de Compostela, Valencia

2025-01-30

Active, closed

Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)

NCT06710132Solid Tumors, Gastric Cancer, Non-Small Cell Lung Cancer (NSCLC), Pancreatic Cancer

DrugM9140

EMD Serono Research & Development Institute, Inc.

Phase 1/2

184

Córdoba, Badalona, Barcelona, L'Hospitalet de Llobregat, Madrid, Pozuelo de Alarcón, Seville, Valencia

2025-01-29

Recruiting

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

NCT06788990Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma

DrugsFicerafusp alfa·Keytruda·Pembrolizumab

Bicara Therapeutics

Phase 2/3

650

Badalona, Barcelona, Madrid, Pamplona, Santander, Valencia

2025-01-28

Recruiting

Effect of Cardiorespiratory Changes on Carotid Flow Time During Lung Resection Surgery

NCT07808749Hemodynamic Monitoring

University of Valencia

Observational

Valencia

2025-01-27

Recruiting

A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease

NCT06100289Ulcerative Colitis, Crohn's Disease

DrugVedolizumab

Takeda

Phase 3

Ferrol, Madrid, Seville, Valencia

2025-01-22

Active, closed

Clinical Study to Evaluate Debio0123 + Sacituzumab Govitecan Combination in TNBC or HR+/HER2- Advanced Breast Cancer

NCT06612203Advanced Breast Cancer

DrugSacituzumab Govitecan

MedSIR

Phase 1/2

Barcelona, Granada, Madrid, Málaga, Valencia

2025-01-17

Recruiting

A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)

NCT06555419Muscular Atrophy, Spinal

DrugNusinersen

Biogen

Phase 1

Madrid, Valencia

2025-01-16

Recruiting

Effectiveness of the Delirium Zero Protocol to Prevent the Onset of Delirium in Patients Undergoing Hip Fracture Surgery

NCT07202208Hip Fracture, Delirium - Postoperative

Cardenal Herrera University

Not applicable

112

Manises, Valencia

2025-01-15

Active, closed

A Study of the Efficacy and Safety of Efgartigimod in Patients With Primary Sjögren's Syndrome

NCT06684847Primary Sjogrens Disease

DrugEfgartigimod PH20

argenx

Phase 3

631

Vitoria-Gasteiz, Badajoz, Barcelona, Santiago de Compostela, Madrid, A Coruña, Seville, Valencia

2025-01-15

Recruiting

A Prospective Observational Study of Video Laryngoscopy Versus Direct Laryngoscopy for Insertion of a Thin Endotracheal Catheter for Surfactant Administration in Newborn Infants

NCT06758492Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS), Video Laryngoscopy, Surfactant

University College Dublin

Observational

600

Valencia

2025-01-13

Recruiting

A Stepped Wedge Cluster Randomised Trial Of Video Versus Direct Laryngoscopy For Intubation Of Newborn Infants

NCT06757543Intubation, Intubation Complications, Infant, Newborn, Infant Respiratory Distress Syndrome

University College Dublin

Not applicable

840

Valencia

2025-01-13

Recruiting

Influence of Menstrual Cycle Phases on the Glycemic Control of Aerobic or HIIT Exercise in Adult Women With Type 1 Diabetes

NCT06729242Diabetes Mellitus, Type I, Menstruation

University of Valencia

Not applicable

Valencia

2025-01-10

Recruiting

A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

NCT06227910Crohn's Disease

DrugsVedolizumab·Upadacitinib

Takeda

Phase 3

396

Madrid, Palma, Pamplona, Santiago de Compostela, Valencia

2025-01-02

By invitation

Evaluation of Pelvic Floor Function and Psychosocial Sequelae Following Radical Prostatectomy for Prostate Cancer

NCT07693647Prostate Cancer (Adenocarcinoma), Radical Prostatectomy, Urinary Incontinence (UI), Erectile Dysfunction Following Radical Prostatectomy

University of Valencia

Observational

Valencia

2025-01-01

Recruiting

Effectiveness of Blood Flow Restriction in Postoperative Rehabilitation for Anterior Cruciate Ligament Injuries. A Pilot Study.

NCT06762392Anterior Cruciate Ligament Reconstruction Rehabilitation

University of Valencia

Not applicable

Valencia

2025-01-01

Active, closed

Tissue Characterization in STEMI Using Cardiac MRI: a Multicenter Registry

NCT07291999Ischemic Cardiovascular Disease, Magnetic Resonance

Fundación para la Investigación del Hospital Clínico de Valencia

Observational

500

Barcelona, Valencia

2025-01-01

Active, closed

Stress CMR With Vasodilators to Predict Long-Term Mortality

NCT07191574Ischemic Heart Disease (IHD), Magnetic Resonance

Fundación para la Investigación del Hospital Clínico de Valencia

Observational

5,552

Valencia

2025-01-01

Not yet open

Trial of an Investigational Drug After Rejecting the Relapse of an Allogeneic Transplant

NCT05982275Multiple Myeloma, Allogeneic Stem Cell Transplantation

Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

Phase 1/2

Santander, Barcelona, Salamanca, Seville, Valencia

2024-12-30

Active, closed

A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa Prophylaxis

NCT06752850Haemophilia A (Moderate or Severe), Hemophilia, Classic, Haemophilia, Hemophilia

DrugEfanesoctocog alfa

Swedish Orphan Biovitrum

Phase 4

Barcelona, Madrid, Seville, Valencia

2024-12-19

Recruiting

REACH: RWE Retrospective Study to Evaluate Cenobamate Impact on Health Care Resource Utilization

NCT06922175Epilepsy With Uncontrolled Focal-onset Seizures

Aziende Chimiche Riunite Angelini Francesco S.p.A

Observational

200

Barcelona, Madrid, Valencia

2024-12-19

Recruiting

A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors

NCT06747585Squamous Non-small-cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Cervical Squamous Cell Carcinoma, Esophageal Squamous Cell Carcinoma

Alentis Therapeutics AG

Phase 1/2

170

PAU de Sanchinarro, Pozuelo de Alarcón, Barcelona, Madrid, Málaga, Seville, Valencia

2024-12-16

By invitation

PrEveNtion of Biliary Events After Acute Pancreatitis in NonSUrgicaL PAtients: PENINSULA Trial

NCT06409741Acute Pancreatitis Due to Gallstones, Acute Pancreatitis

Hospital General Universitario de Alicante

Not applicable

126

Alicante, Córdoba, Madrid, Valencia, Valladolid

2024-12-16

Recruiting

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

NCT06667076Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab

Janssen Research & Development, LLC

Phase 2

480

Barcelona, Jerez de la Frontera, Madrid, Santiago de Compostela, Valencia

2024-12-16

Active, closed

A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

NCT06628310Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Esophageal Adenocarcinoma

DrugsBudigalimab·Telisotuzumab Adizutecan·Fluorouracil·Leucovorin

AbbVie

Phase 2

185

Pamplona, Madrid, Ourense, Valencia

2024-12-13

Recruiting

Phase III Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents

NCT06745557Burns

DrugsDenovoSkin·Ehsg-Kf

CUTISS AG

Phase 3

Barcelona, Madrid, Valencia

2024-12-13

Recruiting

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

NCT06750094Colorectal Neoplasms

DrugsLeucovorin calcium/Levoleucovorin·Amivantamab·Erbitux·Avastin

Janssen Research & Development, LLC

Phase 3

700

Badajoz, Barcelona, Madrid, Málaga, Pamplona, Seville, Valencia

2024-12-12

By invitation

Phase 1b Long-term Extension Trial of RAY121 in Immunological Diseases (RAINBOW-LTE Trial)

NCT06723106Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP), Behçet's Syndrome (BS), Dermatomyositis (DM)

DrugRAY121

Chugai Pharmaceutical

Phase 1

144

Pamplona, Madrid, Barcelona, Córdoba, Seville, Valencia

2024-12-09

Active, closed

Phase 3 Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Participants With Progressive Metastatic Castration-Resistant Prostate Cancer (XALute)

NCT06691984Metastatic Castration-resistant Prostate Cancer

DrugsXaluritamig·Cabazitaxel·Abiraterone·Enzalutamide

Amgen

Phase 3

707

Málaga, Seville, Barcelona, Pamplona, Valencia, Madrid

2024-12-09

Recruiting

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

NCT06667908Carcinoma, Non-Small-Cell Lung

DrugsJNJ-90301900·Durvalumab

Johnson & Johnson Enterprise Innovation Inc.

Phase 2

130

Madrid, Pamplona, Santiago de Compostela, Valencia

2024-12-06

Active, closed

A Long-term Safety and Efficacy Study of N-Acetyl-GED-0507-34-LEVO Gel 5%, in Subjects With Acne Vulgaris (GEDACNE-LT)

NCT07389109Acne Vulgaris

PPM Services S.A.

Phase 3

400

Alcorcón, Barcelona, Esplugues de Llobregat, Granada, Madrid, Málaga, Seville, Valencia

2024-12-05

Recruiting

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

NCT06465953Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS), Myelodysplastic Syndromes (MDS)

DrugsIvosidenib·Azacitidine

Institut de Recherches Internationales Servier

Phase 3

Badalona, Barcelona, Madrid, Pamplona, Salamanca, Seville, Valencia

2024-12-03

Active, closed

A Trial of Amlenetug (Lu AF82422) in Participants With Multiple System Atrophy (MSA)

NCT06706622Multiple System Atrophy

DrugAmlenetug

H. Lundbeck A/S

Phase 3

401

Barcelona, Barcelona (Spain), Madrid, Seville, Valencia

2024-12-03

Recruiting

A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease

NCT06717698Chronic Kidney Disease

DrugSemaglutide

Novo Nordisk A/S

Phase 2

465

Barcelona, Córdoba, Getafe, L'Hospitalet de Llobregat, Madrid, Seville, Valencia

2024-12-02

Active, closed

Oncological Safety of Spleen Preservation in Left Pancreatectomy for Pancreatic Ductal Adenocarcinoma (SPLENDID)

NCT07157605Pancreatic Cancer Resectable, Pancreatectomy

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Observational

Valencia

2024-11-28

Recruiting

A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer

NCT06532006Gastroesophageal-junction Cancer, Monoclonal Antibody, Gastric Cancer, HER2-positive Gastric Cancer

DrugsHLX22·Trastuzumab·Capecitabine·Oxaliplatin

Shanghai Henlius Biotech

Phase 3

550

Barcelona, Madrid, Majadahonda, Oviedo, Seville, Valencia, Vigo

2024-11-22

Recruiting

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

NCT06458712Advanced Cancers (Breast, Ovarian, mCRPC, Pancreatic Ductal Adenocarcinoma (PDAC), Brain Mets) With Specific Mutations (Homologous Recombination Deficiency)

Duke Street Bio Ltd

Phase 1

180

Logroño, Barcelona, Córdoba, Madrid, Málaga, Pamplona, Seville, Valencia

2024-11-21

Recruiting

A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers With Active Chronic Pouchitis

NCT06443502Pouchitis

DrugVedolizumab

Takeda

Phase 3

Esplugues de Llobregat, Valencia

2024-11-19

Active, closed

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

NCT06465329Non-Small Cell Lung Cancer

DrugsMarlotamig·Cemiplimab

Regeneron Pharmaceuticals

Phase 2

120

Badalona, Santander, Las Palmas de Gran Canaria, Pamplona, Madrid, Seville, Valencia, Zaragoza

2024-11-18

Active, closed

A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

NCT06616194Migraine

DrugRimegepant

Pfizer

Phase 3

200

Barcelona, Madrid, Vigo, Seville, Valencia, Valladolid

2024-11-15

Recruiting

A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors

NCT06619587Solid Tumor

Genentech, Inc.

Phase 1

410

Barcelona, Madrid, Málaga, Seville, Valencia

2024-11-14

Active, closed

A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)

NCT06719141Developmental and Epileptic Encephalopathy

DrugBexicaserin

Longboard Pharmaceuticals

Phase 3

367

Esplugues de Llobregat, Pamplona, Barcelona, Madrid, Málaga, Valencia

2024-11-11

Active, closed

A Study of Sequential Therapy With Daplusiran/Tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis B (CHB)

NCT06537414Chronic Hepatitis B Virus Infection, Hepatitis B

DrugBepirovirsen

GlaxoSmithKline

Phase 2

283

Barcelona, León, Madrid, Salamanca, Santander, Valencia

2024-11-11

Active, closed

A Study on Safety and Effectiveness of Long-term Treatment With Vamorolone in Boys With Duchenne Muscular Dystrophy

NCT06713135Duchenne Muscular Dystrophy

DrugVamorolone

Santhera Pharmaceuticals

Phase 4

Madrid, Valencia

2024-11-10

Not yet open

Effects of an Exercise Program in Women Over 60 yr. With HFpEF and Sarcopenia on Functional Capacity and Quality of Life

NCT06655532Heart Failure With Preserved Ejection Fraction (HFpEF), Sarcopenia, Women

Fundación para la Investigación del Hospital Clínico de Valencia

Not applicable

Valencia

2024-11-04

Recruiting

Telerehabilitation-based Exercises vs Standard Home-based Exercise in Low Back Pain

NCT06446596Low Back Pain

University of Valencia

Not applicable

Valencia

2024-11-04

Recruiting

Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

NCT06456593Moderately to Severely Active Crohn Disease

DrugObefazimod

Abivax S.A.

Phase 2

212

Barcelona, Córdoba, Fuenlabrada, Huelva, Las Palmas de Gran Canaria, Santiago de Compostela, Seville, Valencia

2024-10-30

Active, closed

A Study of ZW191 in Participants With Solid Tumors

NCT06555744Advanced Solid Tumors

Zymeworks BC Inc.

Phase 1

145

Barcelona, Córdoba, Madrid, Valencia

2024-10-30

Recruiting

A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

NCT06541704Age-related Macular Degeneration (AMD), Geographic Atrophy (GA)

DrugsCemdisiran·Pozelimab

Regeneron Pharmaceuticals

Phase 3

975

Córdoba, L'Hospitalet de Llobregat, Terrassa, Burjassot, Barcelona, Seville, Valencia, Zaragoza

2024-10-30

Recruiting

International Pilot Study for Dual Non-invasive Assesment of Embryo Development

NCT06524648Infertility

Igenomix

Observational

200

Barcelona, Madrid, Murcia, Seville, Valencia

2024-10-29

Recruiting

A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants

NCT06663332Crohns Disease, Colitis, Ulcerative, Arthritis, Psoriatic, Arthritis, Juvenile

DrugGuselkumab

Janssen Research & Development, LLC

Phase 3

196

Santiago de Compostela, Valencia

2024-10-29

Recruiting

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

NCT06625775Solid Tumor, Adult, Metastatic Breast Cancer, Advanced Breast Cancer, HER2 Mutation-Related Tumors

DrugsBBO-10203·Ribociclib·Folfox·Fulvestrant

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Phase 1

392

Barcelona, Madrid, Pozuelo de Alarcón, Lleida, Valencia

2024-10-29

Recruiting

Flapless Periodontal Regeneration Using Hyaluronic Acid Versus Enamel Matrix Derivative

NCT07339605Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use, Alveolar Bone Loss* / Therapy, Hyaluronic Acid* / Therapeutic Use

University of Valencia

Not applicable

Valencia

2024-10-26

Active, closed

A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy

NCT06413706Glioma

DrugsAbemaciclib·Temozolomide

Eli Lilly and Company

Phase 2

Barcelona, Córdoba, Esplugues de Llobregat, Madrid, Seville, Valencia

2024-10-25

Recruiting

A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer

NCT06638307Advanced Breast Cancer

DrugElacestrant

Stemline Therapeutics, Inc.

Phase 1

240

Barcelona, Madrid, Valencia

2024-10-25

Recruiting

Study of JK06 in Patients With Unresectable Locally Advanced or Metastatic Cancer

NCT06667960Solid Tumor

Salubris Biotherapeutics Inc

Phase 1/2

255

Barcelona, Madrid, Pamplona, Rioja, Valencia

2024-10-23

Recruiting

A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

NCT06629779Metastatic Castration-Resistant Prostate Cancer

DrugsMevrometostat·Xtandi·Enzalutamide

Pfizer

Phase 3

900

L'Hospitalet de Llobregat, Madrid, Valencia

2024-10-22

Recruiting

The Sagittarius Trial

NCT06490536Colon Cancer Stage II, Colon Cancer Stage III

DrugsFolinic acid·Panitumumab·Pertuzumab·Temozolomide

IFOM ETS - The AIRC Institute of Molecular Oncology

Phase 3

700

Barcelona, Valencia, Córdoba, Madrid, Pamplona, Santander, Santiago de Compostela, Zaragoza

2024-10-22

Active, closed

A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).

NCT06551324Metastatic Castrate Resistant Prostate Cancer (mCRPC)

DrugsMevrometostat·Xtandi·Taxotere·Enzalutamide

Pfizer

Phase 3

600

L'Hospitalet de Llobregat, Barcelona, Madrid, Manresa, Valencia

2024-10-21

Recruiting

Transfer Direct System as a New Method for Embryo Transfer

NCT06744049Embryo Transfer

Premium Fertility

Not applicable

Barcelona, Valencia, Seville

2024-10-21

Recruiting

A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia

NCT06544499Primary Immune Thrombocytopenia (ITP)

DrugEfgartigimod

argenx

Phase 3

A Coruña, L'Hospitalet de Llobregat, Madrid, Murcia, Pozuelo de Alarcón, Valencia

2024-10-18

By invitation

Effect of a Therapeutic Exercise and an Education Program on Sexual Function and Experience in People With Endometriosis

NCT06810297Endometriosis, Sexual Function, Sex Behavior

University of Valencia

Not applicable

Valencia

2024-10-18

Recruiting

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

NCT06662786Colorectal Neoplasms

DrugsLeucovorin calcium/Levoleucovorin·Amivantamab·Erbitux·Irinotecan

Janssen Research & Development, LLC

Phase 3

1,000

Barcelona, Madrid, Pamplona, Seville, Valencia

2024-10-18

Active, closed

A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)

NCT06643481Amyotrophic Lateral Sclerosis (ALS)

DrugVHB937

Novartis Pharmaceuticals

Phase 2

251

Santiago Compostela, L'Hospitalet de Llobregat, Barcelona, Valencia

2024-10-17

Active, closed

Robot Asissted Training on Neurodevelopmental Alterations

NCT06645795Neurodevelopmental Disorders, Cerebral Palsy

University of Valencia

Not applicable

Valencia

2024-10-17

Active, closed

Evaluation of Efficacy and Safety of Oral Minoxidil 1 mg in Female Androgenetic Alopecia

NCT05888922Androgenetic Alopecia, Female Pattern Baldness

DrugMinoxidil

Industrial Farmacéutica Cantabria, S.A.

Phase 3

520

Barcelona, Madrid, Valencia

2024-10-17

Active, closed

Phase 3 Study of Daraxonrasib (RMC-6236) in Patients With Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)

NCT06625320Pancreatic Cancer, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma

DrugsLiposomal Irinotecan·Leucovorin·Irinotecan·Cetuximab

Revolution Medicines, Inc.

Phase 3

500

Barcelona, Madrid, Pamplona, Valencia

2024-10-16

Active, closed

RTX001 Autologous Engineered Macrophages for Liver Cirrhosis

NCT06823713End-stage Liver Disease (ESLD), Cirrhosis, Liver, Cirrhosis, Decompensated, Liver Diseases

Resolution Therapeutics Limited

Phase 1/2

Barcelona, Córdoba, Madrid, Seville, Valencia

2024-10-15

Recruiting

Ultrasound Assessment After Surgery for Chronic Anal Fissure

NCT07809711Anal Fissure Chronic

Hospital Clínico Universitario de Valencia

Observational

Valencia

2024-10-12

Recruiting

A Phase II Randomized, Open Label Non-inferiority Study of NiraParib Maintenance After 3 vs. 6 Cycles of Platinum-based Chemotherapy in completeLy debUlked Advanced HRDpositive High-grade Ovarian Cancer patientS in First Line Therapy

NCT05460000Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma, Clear Cell Carcinoma

North Eastern German Society of Gynaecological Oncology

Phase 2

640

Alicante, Granada, Lugo, Madrid, Manresa, Seville, Tarragona, Valencia

2024-10-11

Recruiting

Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations

NCT06581432Solid Tumours

DrugZongertinib

Boehringer Ingelheim

Phase 2

588

A Coruña, Badalona, Barcelona, Madrid, Pamplona, Seville, Valencia

2024-10-11

Active, closed

Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT)

NCT05417789TGCT

DrugEmactuzumab

SynOx Therapeutics Limited

Phase 3

128

Zaragoza, Barcelona, Seville, Valencia

2024-10-09

Recruiting

A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis

NCT06470048Diffuse Cutaneous Systemic Sclerosis

DrugIanalumab

Novartis Pharmaceuticals

Phase 2

200

Málaga, Valencia, Barcelona, Madrid, Salamanca

2024-10-09

Not yet open

Effects of a Supervised Training Program on Functional Capacity in Patients With HF and Cardiorenal Syndrome

NCT06640140Heart Failure, Cardiorenal Syndrome

Fundación para la Investigación del Hospital Clínico de Valencia

Not applicable

Valencia

2024-10-08

Recruiting

A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

NCT06561386Non-small Cell Lung Cancer

DrugsRelatlimab·Pemetrexed·Nivolumab·Cisplatin

Bristol-Myers Squibb

Phase 3

1,000

A Coruña, Barcelona, L'Hospitalet de Llobregat, Palma, Madrid, Majadahonda, Valencia, Málaga

2024-10-07

Recruiting

Six-Month Single-Blind, Placebo-Controlled Study of a Dietary Supplement Supplement on Hair Growth in 45 Volunteers

NCT06841458Androgenetic Alopecia

Industrial Farmacéutica Cantabria, S.A.

Not applicable

Valencia

2024-10-07

Recruiting

A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine

NCT06602479Migraine

AbbVie

Phase 2

488

Badajoz, Barcelona, Madrid, Valencia

2024-10-07

Recruiting

Subcutaneous Tarlatamab in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-308)

NCT06598306Extensive Stage Small Cell Lung Cancer

DrugTarlatamab

Amgen

Phase 1

220

Málaga, Barcelona, Valencia, Madrid

2024-10-07

Recruiting

A Clinical Trial to Define the Best Strategy for the Management of Heart Failure in Elderly Patients

NCT06578078Heart Failure, Chronic Kidney Diseases

DrugSodium Zirconium Cyclosilicate

Fundación para la Investigación del Hospital Clínico de Valencia

Phase 3

Alcorcón, Leganés, Albacete, Burgos, Córdoba, Valencia

2024-10-03

Active, closed

Virtue-Based vs. Cognitive-Behavioral Interventions in Patients With Chronic Medical Disease

NCT06501235Well-Being, Psychological

University of Valencia

Not applicable

100

Valencia

2024-10-02

Active, closed

A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy

NCT06568237Multiple System Atrophy

DrugEmrusolmin

Teva Branded Pharmaceutical Products R&D LLC

Phase 2

349

Barakaldo, Barcelona, Elche, Madrid, Pamplona, Seville, Valencia

2024-10-02

Recruiting

e-Health Program to Prevent Exacerbations in the Cystic Fibrosis Population

NCT06313827Cystic Fibrosis

University of Valencia

Not applicable

Valencia

2024-10-01

Recruiting

A Study of GSK5764227 in Participants With Advanced Solid Tumors (EMBOLD)

NCT06551142Neoplasms

DrugsRis-Rez·Tarlatamab·Dostarlimab·Cetuximab

GlaxoSmithKline

Phase 1

845

Badajoz, Barcelona, Madrid, Málaga, Valencia, Zaragoza

2024-09-30

Recruiting

First-in-human Trial of EGL-001 in Patients with Selected Advanced And/or Metastatic Solid Tumors

NCT06622486Solid Tumor, Adult

Egle Therapeutics

Phase 1/2

Barcelona, Madrid, Pamplona, Valencia

2024-09-27

Recruiting

A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease

NCT06613698Liver Diseases, Alcoholic

DrugGSK4532990

GlaxoSmithKline

Phase 2

393

Barcelona, León, Madrid, Santander, Seville, Valencia, Valladolid, Vigo

2024-09-27

Active, closed

Inspiratory Muscle Training in Amateur Athletes

NCT06611969Amateur Athletes

University of Valencia

Not applicable

Valencia

2024-09-26

Active, closed

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

NCT06525220Head and Neck Squamous Cell Carcinoma

DrugsPetosemtamab·Pembrolizumab

Merus B.V.

Phase 3

699

Badalona, Barcelona, Madrid, Marbella, Pamplona, Valencia

2024-09-25

Active, closed

A Phase 1b Study to Investigate Safety and Tolerability of ARGX-119 in Adult Participants With DOK7-Congenital Myasthenic Syndromes (CMS)

NCT06436742Congenital Myasthenic Syndrome, CMS

DrugARGX-119

argenx

Phase 1

Valencia

2024-09-24

Active, closed

A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer

NCT06497556Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer

DrugsDivarasib·Adagrasib·Sotorasib

Hoffmann-La Roche

Phase 3

338

L'Hospitalet de Llobregat, Seville, Barcelona, Madrid, Málaga, Valencia, Zaragoza

2024-09-23

Active, closed

To Evaluate the Efficacy of CVN424 in Parkinson's Disease Participants With Motor Complications

NCT06553027Parkinson Disease

Cerevance

Phase 3

330

Seville, Sant Cugat del Vallès, Barakaldo, San Sebastián, Valencia, Barcelona, Madrid

2024-09-20

Active, closed

A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC in Adults With Ocular Myasthenia Gravis

NCT06558279Myasthenia Gravis, Ocular

argenx

Phase 3

141

Barcelona, Madrid, San Sebastián, Valencia

2024-09-18

Recruiting

Ovulation Trigger Strategies in Low Ovarian Reserve (TRIGGERBEST)

NCT07816562Low Ovarian Reserve, Poor Ovarian Response

DrugsFollitropin delta·Human chorionic gonadotropin·Elacestrant

Fundación para la Investigación del Hospital Clínico de Valencia

Phase 3

126

Valencia

2024-09-17

Active, closed

A Study to Assess the Efficacy and Safety of Afimkibart (Also Known as RO7790121) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis

NCT06589986Moderately to Severely Active Ulcerative Colitis

DrugAfimkibart

Hoffmann-La Roche

Phase 3

400

Santander, Valencia

2024-09-17

Recruiting

A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B

NCT06379789Hemophilia B

Regeneron Pharmaceuticals

Phase 1/2

130

Seville, A Coruña, El Palmar, Oviedo, Barcelona, Madrid, Valencia, Zaragoza

2024-09-11

Active, closed

RVU120 for Treatment of Anemia in Patients With Lower-risk Myelodysplastic Neoplasms

NCT06243458Low Risk Myelodysplastic Syndromes

DrugRVU120

GCP-Service International West GmbH

Phase 2

Barcelona, León, Madrid, Pamplona, Salamanca, Valencia

2024-09-10

Recruiting

Therapeutic-educational Physiotherapy on Pain, Physical-functionality and Quality of Life in Women With Endometriosis.

NCT06212349Endometriosis, Chronic Pain, Women's Health

University of Valencia

Not applicable

Valencia

2024-09-09

Active, closed

A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

NCT06581198Lupus Erythematosus, Systemic, Lupus Nephritis

DrugRapcabtagene autoleucel

Novartis Pharmaceuticals

Phase 2

179

Santiago Compostela, Santander, Pamplona, Barcelona, Córdoba, Madrid, Salamanca, Valencia

2024-09-04

Recruiting

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

NCT06548542Crohn's Disease

DrugsABBV-8736·Trosunilimab·Lutikizumab·Risankizumab

AbbVie

Phase 2

590

Santiago de Compostela, Seville, Barcelona, Madrid, Pontevedra, Valencia

2024-09-04

Recruiting

A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

NCT06528314NASH - Nonalcoholic Steatohepatitis, MASH - Metabolic Dysfunction-Associated Steatohepatitis

DrugEfruxifermin

Akero Therapeutics, Inc

Phase 3

2,150

Sabadell, Santander, Majadahonda, Barcelona, Madrid, Seville, Valencia

2024-09-04

Recruiting

The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect

NCT06058585Chronic Kidney Diseases

DrugsFinerenone·Semaglutide

The George Institute

Phase 3

2,000

Badalona, Horta-Guinardó, Valencia

2024-09-04

Active, closed

A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

NCT06616974Pulmonary Hypertension, Heart Failure With Preserved Ejection Fraction

Tectonic Therapeutic

Phase 2

191

Barcelona, Madrid, Santiago de Compostela, Valencia

2024-09-04

Recruiting

CRS Questionnaire Validation Project

NCT06970977Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps

The European Forum for Research and Education in Allergy and Airway Diseases

Observational

1,000

A Coruña, Barcelona, Cadiz, Madrid, Ponferrada, Santander, Seville, Valencia

2024-09-01

By invitation

Barriers to Therapeutic Exercise in Breast Cancer Patients Before, During, and After Chemotherapy

NCT06828614Breast Cancer

University of Valencia

Observational

111

Valencia

2024-09-01

Active, closed

A Study to Evaluate the Safety and the Activity of S095029 as Part of Combination Therapy in Advanced Gastroesophageal Junction/Gastric Cancers.

NCT06116136MSI-H/dMMR Gastroesophageal-junction Cancer, MSI-H/dMMR Gastric Cancer

DrugsS095029·Keytruda·Pembrolizumab

Servier Bio-Innovation LLC

Phase 1/2

Barcelona, Madrid, Santander, Valencia

2024-08-31

Active, closed

Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)

NCT06564142Immunoglobulin A Nephropathy

DrugPovetacicept

Alpine Immune Sciences Inc, A Subsidiary of Vertex

Phase 3

605

Barcelona, Córdoba, Lleida, Madrid, Pamplona, Santiago de Compostela, Seville, Valencia

2024-08-30

Active, closed

A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma

NCT06425302Lymphoma, Follicular

DrugsEndoxan·Golcadomide·Pegylated liposomal doxorubicin·Bendamustine

Celgene

Phase 2

Palma, Valencia, Madrid

2024-08-30

Active, closed

A Phase 1b Trial to Evaluate Safety of MB097 in Combination With Pembrolizumab in Melanoma Patients

NCT06540391Melanoma

DrugsVancomycin·Keytruda·Pembrolizumab

Microbiotica Ltd

Phase 1

Madrid, Valencia

2024-08-28

Recruiting

A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

NCT06452277Advanced Non-small Cell Lung Cancer, HER2 Mutation

DrugsSevabertinib·Pemetrexed·Cisplatin·Carboplatin

Bayer

Phase 3

555

Badalona, Majadahonda, Pamplona, A Coruña, Barcelona, Madrid, Valencia

2024-08-28

Active, closed

A Study of Obexelimab in Patients With Relapsing Multiple Sclerosis (MoonStone)

NCT06564311Relapsing Multiple Sclerosis

DrugObexelimab

Zenas BioPharma (USA), LLC

Phase 2

Madrid, Málaga, Murcia, Seville, Valencia

2024-08-26

Recruiting

A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT06290141Chronic Inflammatory Demyelinating Polyneuropathy

DrugsRiliprubart·IVIG

Sanofi

Phase 3

160

Santiago de Compostela, Barcelona, Majadahonda, Pamplona, Málaga, Sabadell, Santa Cruz de Tenerife, Valencia

2024-08-21

Recruiting

CEB-01 in Locally Resectable Pancreatic Cancer

NCT06538857Pancreatic Carcinoma

DrugCEB-01

CEBIOTEX

Early Phase 1

Barcelona, Madrid, Seville, Valencia

2024-08-20

Recruiting

A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

NCT06033950Heart Failure

DrugFinerenone

Colorado Prevention Center

Phase 3

2,600

Girona, A Coruña, Santiago de Compostela, Madrid, Majadahonda, Málaga, Manises, Valencia

2024-08-20

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis

NCT06461897Atopic Dermatitis

DrugsUpadacitinib·Dupilumab

AbbVie

Phase 3

675

Esplugues de Llobregat, Madrid, Valencia, Zaragoza

2024-08-19

Recruiting

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

NCT06371417Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP), Behçet's Syndrome (BS), Dermatomyositis (DM)

DrugRAY121

Chugai Pharmaceutical

Phase 1

144

Pamplona, Madrid, Barcelona, Córdoba, Seville, Valencia

2024-08-19

Recruiting

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

NCT06395103B-cell Acute Lymphoblastic Leukemia, Diffuse Large B-cell Lymphoma, Burkitt Lymphoma, Neuroblastoma

DrugZilovertamab vedotin

Merck Sharp & Dohme LLC

Phase 1/2

Esplugas de Llobregat, Madrid, Valencia, Barcelona

2024-08-16

Recruiting

A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)

NCT06292780Relapsed/Refractory Systemic Light Chain Amyloidosis

DrugLinvoseltamab

Regeneron Pharmaceuticals

Phase 1/2

220

Palma, Pamplona, Gijón, Barcelona, Valencia

2024-08-07

Active, closed

Phase 1b/2 Platform Study of Select Immunotherapy Combinations in Participants With Advanced Non-small Cell Lung Cancer (NSCLC)

NCT06162572Non-small Cell Lung Cancer (NSCLC)

DrugsS095029·Cemiplimab

Servier Bio-Innovation LLC

Phase 1/2

102

Barcelona, Madrid, Málaga, Valencia

2024-08-07

Active, closed

An Extension and Crossover Vaccination Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 60 Years of Age and Above Who Participated in RSV OA=ADJ-006 Study

NCT06534892Respiratory Syncytial Virus Infections

DrugRSVPreF3 OA vaccine

GlaxoSmithKline

Phase 3

10,212

Santiago de Compostela, Centelles, Vic, Majadahonda, Alcorcón, Barcelona, Madrid, Valencia

2024-08-01

Recruiting

Transition to Hospital Discharge in Insulinized Patients With Type 2 Diabetes Mellitus

NCT07061301Type 2 Diabetes Mellitus (T2DM), Continuous Glucose Monitoring, CGM, Transition to Discharge

Instituto de Investigacion Sanitaria La Fe

Not applicable

Valencia

2024-08-01

Active, closed

A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.

NCT06517758Generalized Myasthenia Gravis

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

146

Santiago Compostela, L'Hospitalet de Llobregat, Alicante, Barcelona, Lleida, Madrid, Málaga, Valencia

2024-07-31

Active, closed

Effect of the Use of Dapagliflozin in Patients With Refractory Heart Failure

NCT06578520Heart Failure

DrugDapagliflozin

Fundación para la Investigación del Hospital Clínico de Valencia

Phase 4

Valencia

2024-07-30

Active, closed

A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA)

NCT06510816Geographic Atrophy

DrugVonaprument

Annexon, Inc.

Phase 3

659

Valencia, Barcelona, Córdoba, Madrid, Majadahonda, Sant Cugat del Vallès, Santiago de Compostela, Seville

2024-07-30

Active, closed

A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression

NCT06365853Recurrent Ovarian Cancer, Folate Receptor-Alpha Positive

DrugsMIRV·Mirvetuximab Soravtansine

AbbVie

Phase 2

108

Barcelona, Cáceres, Jaén, Madrid, Valencia

2024-07-29

Recruiting

Efficacy of Biomarkers and CEUS Versus CTA in AAA Follow-up Post-EVAR

NCT06866769Abdominal Aortic Aneurysm Without Rupture

Instituto de Investigacion Sanitaria La Fe

Observational

Valencia

2024-07-25

Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Spanish investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 13 October 2026. https://priyalifescience.com/clinical-trials-spain/city/valencia

Query this register directly

GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Spain and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 5,875 studies in total at the last sync on 11 Oct 2026, 03:18 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,215 of those studies with a site in Valencia.

How many clinical trials are recruiting in Valencia?

621 of the 1,215 studies on this page are recruiting new participants as of the 11 Oct 2026, 03:18 UTC sync. A further 43 have not yet opened recruitment, 517 are active but closed to new participants, and 34 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Valencia), 1,215 studies
Phase	Studies	Recruiting	Share
Phase 3	466	203	38.4%
Phase 2	211	97	17.4%
Not applicable	158	98	13%
Phase 1/2	116	68	9.5%
Observational	111	72	9.1%
Phase 1	98	49	8.1%
Phase 2/3	38	25	3.1%
Phase 4	16	8	1.3%
Early Phase 1	1	1	0.1%

Most active sponsors

Lead sponsors with the most studies (Valencia)
Lead sponsor	Studies	Recruiting
University of Valencia	61	40
AstraZeneca	60	31
Novartis Pharmaceuticals	42	14
Hoffmann-La Roche	41	16
AbbVie	39	21
Merck Sharp & Dohme LLC	38	22
Eli Lilly and Company	34	15
Bristol-Myers Squibb	31	14
Janssen Research & Development, LLC	25	16
Pfizer	23	13

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.