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Clinical Trials in Spain / NCT07316933
Recruiting Not applicable

Acute Exercise Responses With Blood Flow Restriction Under Dynamic Pressure Compared to Fixed Pressure in Patients With Severe Gonarthrosis

NCT07316933 · tracked via the Priya Life Science Spain tracker
Sponsor
University of Valencia
Phase
Not applicable
Started
2026-03-01
Last updated
2026-06-10

Condition(s) studied

Severe Knee Osteoarthritis

Investigational drug(s) / intervention(s)

Low-intensity resistance exercise with moderate arterial occlusion pressure and dynamic pressure.Low-intensity resistance exercise with moderate arterial occlusion pressure and fixed pressure.Moderate-intensity resistance exercise with low arterial occlusion pressure and dynamic pressure.Moderate-intensity resistance exercise with low arterial occlusion pressure and fixed pressure.Low-intensity resistance exercise with high arterial occlusion pressure and dynamic pressure.Low-intensity resistance exercise with high arterial occlusion pressure and fixed pressure.

Low-intensity resistance exercise with moderate arterial occlusion pressure and dynamic pressure.: A single quadriceps extension exercise at 30% of 1 repetition maximum (1RM) with dynamic occlusion at 50% of limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.

Low-intensity resistance exercise with moderate arterial occlusion pressure and fixed pressure.: A single quadriceps extension exercise at 30% of 1RM with fixed occlusion at 50% of limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.

Moderate-intensity resistance exercise with low arterial occlusion pressure and dynamic pressure.: A single quadriceps extension exercise at 50% of 1RM with dynamic occlusion at 30% of limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.

Moderate-intensity resistance exercise with low arterial occlusion pressure and fixed pressure.: A single quadriceps extension exercise at 50% of 1RM with a fixed occlusion of 30% of the limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.

Low-intensity resistance exercise with high arterial occlusion pressure and dynamic pressure.: A single quadriceps extension exercise at 15% of 1RM with a dynamic occlusion of 80% of the limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.

Low-intensity resistance exercise with high arterial occlusion pressure and fixed pressure.: A single quadriceps extension exercise at 15% of 1RM with a fixed occlusion of 80% of the limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.

Study summary

This study aims to evaluate the acute effects of blood flow restriction (BFR) training on hypoalgesia and neuromuscular responses in patients with severe gonarthrosis by comparing the application of pressure with a dynamic versus a fixed configuration. There will be six different training conditions with varying levels of blood flow occlusion (%BFR) and percentage of load (%RM): 1) 30% RM and 50% BFR with dynamic pressure; 2) 30% RM and 50% BFR with fixed pressure; 3) 50% RM and 50% BFR with dynamic pressure; 4) 50% RM and 50% BFR with fixed pressure; 5) 30% RM and 80% BFR with dynamic pressure; 6) 30% RM and 80% BFR with fixed pressure.

Each participant will complete six individual sessions under different training conditions, assigned in a random order with a 72-hour interval between each session.

Eligibility

Sex
ALL
Min age
50 Years
Max age
85 Years
Healthy volunteers
No
Inclusion Criteria: * Age between 50 and 85 years * Diagnosis of severe gonarthrosis according to the clinical and radiographic criteria of the American College of Rheumatology guidelines. * On the waiting list for unilateral total knee replacement (TKR) surgery Exclusion Criteria: * Pain in the contralateral leg with an intensity ≥80/100 mm on the visual analog scale (VAS) during daily activities. * Previous hip or knee replacement surgery and osteotomy within the last year. * Autoimmune arthritis * Medical conditions that contraindicate exercise. * Participation in exercise programs (\>2 days/week with training at intensities of 10-15 1RM) in the previous six months. * History of stroke, brain surgery, major depression, or self-reported cognitive impairment that could affect performance in the study. * Cardiovascular, thrombotic, or vascular risk factors (uncontrolled hypertension, peripheral arterial disease, history of deep vein thrombosis or pulmonary embolism, heart failure, severe varicose veins, or uncontrolled anticoagulant therapy). * Skin or local alterations at the cuff application site (ulcers, open wounds, infections, lymphedema, or severe edema). * Inability to communicate normally or with impaired communication skills.

Primary outcome measure(s)

  • Pain intensity at rest (Visual Analogue Scale, 0-10) — Periprocedural
    Pain intensity perceived on a Visual Analogue Scale, at rest, being 0 no pain and 10 the worst pain imaginable.

Trial sites (1)

FacilityCityRegionStatus
University of Valencia Valencia Valencia Recruiting

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Other trials for the same condition

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07316933 on ClinicalTrials.gov ↗ ← All trials in Spain