Ireland
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Priya Life Science Compound trial record
Compound · clinical trials

Elebsiran clinical trials

Also listed in trial records as VIR-2218, BRII-835
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 5 trials in our UK, Germany, France, Spain, Italy, Netherlands, Austria, Belgium, USA, Canada and China registers that name Elebsiran as an intervention. Synced 10 Nov 2026
5Current trials
1Recruiting now
2Lead sponsors
11Country registers
At a glance

Elebsiran is named as an intervention in 5 current clinical trials in our UK, Germany, France, Spain, Italy, Netherlands, Austria, Belgium, USA, Canada and China registers. 1 is recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is Vir Biotechnology, Inc (4). The most-studied condition is Viral Hepatitis.

Where Elebsiran is approved

All regulators →
USUnited States (FDA)
No FDA approval of a single-substance product in Drugs@FDA
First original NDA/BLA approval
EUEuropean Union (EMA)
No centralised EU authorisation (it may be authorised nationally)
First centralised authorisation
CACanada (Health Canada)
No new-drug Notice of Compliance since 1994
First new-drug NOC

From the regulators' own registers: FDA Drugs@FDA, the EMA medicines list and Health Canada's Notice of Compliance database. Dates are the first listed approval of a product containing only this substance; combination products and nationally authorised EU medicines are not counted.

How Elebsiran works

All drug targets →
Diseases it has been tested for in clinical trials, by furthest phase
  • Hepatitis D virus infectionPhase 3
  • Chronic hepatitis B virus infectionPhase 2
  • Hepatitis B virus infectionPhase 2

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL5315044, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 14728, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for Elebsiran

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting120%
  • Active, closed480%

Trials by phase

  • Phase 2360%
  • Phase 3240%
01

Clinical trials of Elebsiran

5 trials
StudyPhaseStatusLead sponsorRegisters
A Study to Evaluate the Efficacy and Safety of Combination Therapy of BRII-179, BRII-835 and PEG-IFNα in Participants With Chronic Hepatitis B Virus (HBV) Infection (ENHANCE)
NCT06650852 · ClinicalTrials.gov ↗ · Chronic Hepatitis B Virus (HBV) Infection
Phase 2 Recruiting Brii Biosciences Limited China
A Study to Evaluate Tobevibart + Elebsiran in Chronic HDV Infection
NCT06903338 · Viral Hepatitis
Phase 3 Active, closed Vir Biotechnology, Inc UK, USA, Germany, Canada
A Study to Evaluate Tobevibart+Elebsiran in Participants With Chronic HDV Infection Not Virologically Suppressed With Bulevirtide
NCT07128550 · Viral Hepatitis
Phase 3 Active, closed Vir Biotechnology, Inc UK, Germany, France, Spain, Italy, Austria
SOLSTICE: Combination Therapy for the Treatment of Chronic Hepatitis D Infection.
NCT05461170 · Hepatitis D, Chronic
Phase 2 Active, closed Vir Biotechnology, Inc UK, Germany, France, Italy, Netherlands
A Study to Evaluate Tobevibart+Elebsiran Versus Bulevirtide in Chronic HDV Infection
NCT07142811 · Viral Hepatitis
Phase 2 Active, closed Vir Biotechnology, Inc UK, Germany, France, Spain, Netherlands, Belgium

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Elebsiran

3 conditions
Viral Hepatitis3Hepatitis D, Chronic1Chronic Hepatitis B Virus (HBV) Infection1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Vir Biotechnology, Inc4
Brii Biosciences Limited1
04

By country register

RegisterTrialsRecruiting
Clinical trials in UK40
Clinical trials in Germany40
Clinical trials in France30
Clinical trials in Spain20
Clinical trials in Italy20
Clinical trials in Netherlands20
Clinical trials in Austria10
Clinical trials in Belgium10
Clinical trials in USA10
Clinical trials in Canada10
Clinical trials in China11

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Elebsiran trials

How many clinical trials are testing Elebsiran?

5 current trials in our UK, Germany, France, Spain, Italy, Netherlands, Austria, Belgium, USA, Canada and China registers name Elebsiran (also registered as VIR-2218) as a drug or biological intervention, as of the registry sync on 10 November 2026. Completed and withdrawn studies are not counted.

Are Elebsiran trials recruiting patients?

Yes. 1 of the 5 trials is recruiting: 1 with sites in China. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Elebsiran clinical trials?

Vir Biotechnology, Inc (4) and Brii Biosciences Limited (1). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Elebsiran works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Elebsiran works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Elebsiran (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 10 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.