A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Condition(s) studied
Investigational drug(s) / intervention(s)
BMS-986507: Specified dose on specified days
Osimertinib: Specified dose on specified days
Pembrolizumab: Specified dose on specified days
Nivolumab: Specified dose on specified days
Pumitamig: Specified dose on specified days
Study summary
The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.
Eligibility
Primary outcome measure(s)
- Number of participants with adverse events (AEs) — Up to 3 years
- Number of participants with serious adverse events (SAEs) — Up to 3 years
- Number of participants with AEs meeting protocol defined dose-limiting toxicity (DLT) critera — Up to 3 years
- Number of participants with AEs leading to discontinuation — Up to 3 years
- Number of participants with AEs leading to death — Up to 3 years
- Number of DLTs that occur during the DLT evaluation period — Up to 3 weeks
Trial sites (65)
| Facility | City | Region | Status |
|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | Recruiting |
| University of Miami Hospital and Clinics, Sylvester Cancer Center | Miami | Florida | Recruiting |
| Local Institution - 0065 | Iowa City | Iowa | Not Yet Recruiting |
| Local Institution - 0140 | St Louis | Missouri | Not Yet Recruiting |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | Recruiting |
| Cleveland Clinic | Cleveland | Ohio | Recruiting |
| Local Institution - 0102 | Columbus | Ohio | Not Yet Recruiting |
| Providence Portland Medical Center | Portland | Oregon | Recruiting |
| Providence St. Vincent Medical Center | Portland | Oregon | Recruiting |
| Local Institution - 0052 | Portland | Oregon | Not Yet Recruiting |
| Local Institution - 0014 | Pittsburgh | Pennsylvania | Withdrawn |
| University of Tennessee Medical Center | Knoxville | Tennessee | Recruiting |
| NEXT Oncology - Irving | Irving | Texas | Recruiting |
| Swedish Medical Center | Seattle | Washington | Recruiting |
| Liverpool Hospital | Liverpool | New South Wales | Recruiting |
| Princess Alexandra Hospital | Woolloongabba | Queensland | Recruiting |
| Peter MacCallum Cancer Centre | Melbourne | Victoria | Recruiting |
| St. John of God Subiaco Hospital | Subiaco | Western Australia | Recruiting |
| Cross Cancer Institute | Edmonton | Alberta | Recruiting |
| Local Institution - 0064 | Newmarket | Ontario | Not Yet Recruiting |
| Local Institution - 0023 | Ottawa | Ontario | Withdrawn |
| The Ottawa Hospital - General Campus | Ottawa | Ontario | Recruiting |
| Centre Hospitalier de l'Université de Montréal | Montreal | Quebec | Recruiting |
| Jewish General Hospital | Montreal | Quebec | Recruiting |
| Local Institution - 0144 | Montreal | Quebec | Not Yet Recruiting |
| Oncocentro Valdivia | Valdivia | Los Ríos Region | Recruiting |
| FALP | Santiago | Santiago Metropolitan | Recruiting |
| Pontificia Universidad Catolica de Chile | Santiago | Santiago Metropolitan | Recruiting |
| Bradfordhill | Santiago | Santiago Metropolitan | Recruiting |
| Oncocentro Apys | Viña del Mar | Valparaiso | Recruiting |
| Local Institution - 0077 | Nice | Alpes-Maritimes | Withdrawn |
| Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest | Bordeaux | Aquitaine | Recruiting |
| Centre Leon Berard | Lyon | Auvergne-Rhône-Alpes | Recruiting |
| Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone | Marseille | Bouches-du-Rhône | Recruiting |
| Local Institution - 0076 | Caen | Calvados | Withdrawn |
| Hôpital Arnaud de Villeneuve - CHU Montpellier | Montpellier | Hérault | Recruiting |
| Gustave Roussy | Villejuif | Val-de-Marne | Recruiting |
| Institut Curie | Paris | France | Recruiting |
| Hôpital Tenon | Paris | France | Recruiting |
| Cro-Irccs | Aviano | Friuli Venezia Giulia | Recruiting |
+ 25 more sites — see the full list on the official registry below.
On this site
📄 Tagrisso (osimertinib) drug profile → 📄 Keytruda (pembrolizumab) drug profile → 📄 Opdivo (nivolumab) drug profile →More Bristol-Myers Squibb trials in Spain
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06618287 on ClinicalTrials.gov ↗ ← All trials in Spain