Clinical trial register · Netherlands

Clinical Trials in Nijmegen, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Netherlands and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 3171 matching records held by the registry are in this view. Synced 10 Nov 2026, 03:17 UTC

3171

Studies in scope

all four open statuses

1789

Recruiting now

open to new participants

601

Lead sponsors

across recruiting studies

Top sites

Amsterdam 1239 Rotterdam 853 Groningen 601 Nijmegen 565 Utrecht 543

Trials with a site in Nijmegen

Status

Study

Lead sponsor

Phase

Enrol

Sites in Netherlands

Start

Not yet open

Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II

NCT07287358Traumatic Brain Injury, Severe Traumatic Brain Injury, Intracranial Pressure, Cerebral Perfusion Pressure

Maastricht University Medical Center

Not applicable

Enschede, Maastricht, Nijmegen, The Hague

2027-01-01

Not yet open

A Research Study to Investigate How Well the Medicine CagriSema Lowers High Blood Pressure in People Living With High Blood Pressure and Obesity

NCT07919405Hypertension, Obesity

DrugsCagriSema·Cagrilintide·Semaglutide

Novo Nordisk A/S

Phase 3

1,408

Deventer, Dordrecht, Eindhoven, Haarlem, Heerlen, Hoogeveen, Nijmegen, Utrecht

2026-11-11

Recruiting

A Clinical Trial To Investigate The Effect Of EA-230 On Hospital Length Of Stay In Patients With Coronary Artery Disease (CAD) Undergoing Coronary Artery Bypass Grafting (CABG) Surgery.

NCT07357675Coronary Artery Disease (CAD), Coronary Artery Bypass Graft Surgery(CABG)

EBI Anti Sepsis BV

Phase 3

300

Enschede, Nijmegen

2026-10-29

Recruiting

Fight Osteosarcoma Through European Research Evolving Study Platform From Diagnosis to Relapse

NCT07871864Osteosarcoma, Pediatric Osteosarcoma, Osteosarcoma in Children, Osteosarcoma in Adolescents and Young Adults

Gustave Roussy, Cancer Campus, Grand Paris

Phase 3

530

Groningen, Leiden, Nijmegen, Utrecht

2026-10-07

Not yet open

Preventive Dendritic Cell Vaccination for Lynch Syndrome Carriers

NCT07609901Lynch Syndrome

DrugDC vaccination

Radboud University Medical Center

Phase 3

372

Nijmegen

2026-10-01

Not yet open

Deposition of Inhaled Liposomal Amphotericin B in Chronic Pulmonary Aspergillosis (CPA)

NCT07530263Chronic Pulmonary Aspergillosis

Radboud University Medical Center

Phase 1

Nijmegen

2026-10-01

Recruiting

Drug Repurposing in Thyroid Carcinoma: a Feasibility Trial

NCT07485569Thyroid Cancer Stage IV, Anaplastic Thyroid Cancer, Differentiated Thyroid Cancer, Poorly Differentiated Thyroid Carcinoma

Radboud University Medical Center

Phase 1

Nijmegen

2026-10-01

Not yet open

Brachytherapy (Interventional Radiotherapy) for Squamous Cell Carcinomas of the Nasal Vestibule: Optimization of Dose and Technique

NCT07801690Carcinoma Nasal Vestibule

Radboud University Medical Center

Observational

300

Nijmegen

2026-10-01

Not yet open

Preventive Dendritic Cell Vaccination for Lynch Syndrome

NCT07412197Lynch Syndrome

DrugDC vaccination

Radboud University Medical Center

Phase 1/2

Nijmegen

2026-10

Not yet open

Overcoming Immunotherapy Resistance in Hepatocellular Carcinoma

NCT07895342Hepatocellular Carcinoma Non-Resectable

Radboud University Medical Center

Not applicable

Nijmegen

2026-10

Not yet open

Diaphragm Hibernation and Its Driving Factors in Mechanically Ventilated ICU Patients

NCT07819864Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation, Respiratory Failure, ICU

Radboud University Medical Center

Observational

112

Nijmegen

2026-10

Recruiting

A Trial to Compare Treatment With Surlorian (ARM210, S48168) to Placebo in Effects on Muscle Strength and Safety in Adults With Autosomal Dominant RYR1-related Myopathy

NCT07560020Autosomal Dominant RYR1-Related Myopathy

RyCarma Therapeutics, Inc.

Phase 2

Nijmegen

2026-09-09

Recruiting

A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia

NCT07623200Essential Thrombocythemia

DrugINCA033989

Incyte Corporation

Phase 3

426

Amsterdam, Groningen, Nijmegen, Rotterdam, Utrecht

2026-09-08

Recruiting

Pre Hospital Triage of Patients at Intermediate and High Risk for ACS

NCT07252245Non ST Segment Elevation Acute Coronary Syndrome

Cyril Camaro

Not applicable

1,048

Haps, Nijmegen

2026-09-04

Not yet open

Thyroid Hormone Replacement After Radio Iodine: Value and Efficacy

NCT06647602Differentiated Thyroid Cancer, Thyroid Cancer, Levothyroxine, Liothyronine

DrugsCytomel·Levothyroxine

University Medical Center Groningen

Observational

Groningen, Nijmegen

2026-09-01

Not yet open

A Physical Activity Programme Focussed on Step Volume and Intensity for People With Cardiovascular Disease: Getting Active and Staying Active After Cardiac Rehabilitation

NCT07723274Coronary Artery Disease

Radboud University Medical Center

Not applicable

334

Arnhem, Nijmegen, Uden

2026-09-01

Recruiting

Prospective Prostate Cancer Infrastructure

NCT07560748High Risk Localized Prostate Cancer, Synchronous Metastatic Hormone-Sensitive Prostate Cancer

Radboud University Medical Center

Observational

700

Nijmegen

2026-09-01

Not yet open

Clinical Performance of CAD/CAM Occlusal Splints Fabricated With or Without a Wax Bite Registration in Healthy Adults

NCT07720453Occlusion, Occlusal Splints, Occlusal Analysis, Comfort

Radboud University Medical Center

Not applicable

Nijmegen

2026-09-01

Not yet open

Study of Serine Supplementation to Protect Vision in MacTel

NCT07342439Macular Telangiectasia Type 2 (MacTel)

The Lowy Medical Research Institute Limited

Phase 3

120

Nijmegen

2026-09

Recruiting

Timing of Immunotherapy in Melanoma

NCT07696715Melanoma

Radboud University Medical Center

Not applicable

170

Amsterdam, Leiden, Nijmegen, Rotterdam

2026-08-10

Recruiting

Modafinil for Debilitating Fatigue in Quiescent Inflammatory Bowel Disease MODIFI-IBD Trial)

NCT07582458Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Chronic Fatigue

DrugModafinil

Radboud University Medical Center

Phase 2/3

Arnhem, Nijmegen

2026-08-03

Recruiting

A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF)

NCT07742735Short Bowel Syndrome (SBS), SBS Associated With Intestinal Failure (SBS-IF)

DrugApraglutide

VectivBio AG

Phase 3

124

Nijmegen

2026-08

Not yet open

Long-Term Extension Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon Skipping to Evaluate the Safety and Efficacy of Endosomal Escape Vehicle Phosphorodiamidate Morpholino Oligomer Platform Products (ELEVATE-LTE)

NCT07682129Duchenne Muscular Dystrophy (DMD)

DrugsENTR-601-44·ENTR-601-45

Entrada Therapeutics, Inc.

Phase 2

Leiden, Nijmegen

2026-08

Recruiting

Dietary Fiber to Induce Gut Microbiota-mediated Response to Immunotherapy in Melanoma.

NCT07686835Melanoma (Skin) Stage IV, Melanoma (Skin Cancer), Melanoma Metastatic, Melanoma Advanced

Radboud University Medical Center

Phase 2

Nijmegen, Groningen

2026-07-31

Recruiting

HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB

NCT07575308Von Willebrand Disease (VWD), Heavy Menstrual Bleeding (HMB)

DrugALN-6400

Alnylam Pharmaceuticals

Phase 2

Nijmegen, Utrecht

2026-07-30

Recruiting

A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis

NCT07497087Systemic Sclerosis

Boehringer Ingelheim

Phase 3

448

Groningen, Nijmegen, Rotterdam

2026-07-27

Recruiting

A Study to Investigate Velzatinib Compared With Imatinib in Adult Participants With Previously Untreated Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (StrateGIST Frontline)

NCT07585266Gastrointestinal Stromal Neoplasms

DrugsVelzatinib·Imatinib

GlaxoSmithKline

Phase 3

800

Leiden, Nijmegen

2026-07-27

Recruiting

Promoting Response to IMmunotherapy by Exercise in Patients With Advanced Renal Cell Carcinoma

NCT07680556Oncology

Radboud University Medical Center

Not applicable

Arnhem, Nijmegen

2026-07-22

Recruiting

Discontinuation of Disease-modifying Anti-rheumatic Drugs (DMARDs) in Rheumatoid Arthritis Patients Also Using TNF Inhibitors

NCT07802678Rheumatoid Arthritis (RA)

Sint Maartenskliniek

Phase 4

202

Nijmegen, Tilburg, Amsterdam, Rotterdam

2026-07-14

Recruiting

[68Ga]BED003 PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications

NCT07702292Colorectal Cancer, Epithelial Ovarian Cancer, Gastric Cancer (GC), Pancreatic Ductal Adenocarcinoma (PDAC)

Blue Earth Diagnostics

Phase 2

Groningen, Nijmegen

2026-06-30

Recruiting

A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)

NCT07554339Non-small Cell Lung Cancer

DrugsCalderasib·Durvalumab

Merck Sharp & Dohme LLC

Phase 3

310

Nijmegen, Hengelo, Leiden, Groningen

2026-06-18

Recruiting

Open Label Extension to Assess Long Term Safety and Efficacy of KL1333 in Patients With Primary Mitochondrial Disease

NCT07514338Mitochondrial Diseases

DrugNapazimone

Pharming Technologies B.V.

Phase 2

140

Nijmegen

2026-06-12

Recruiting

A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy

NCT07498426Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS)

Novartis Pharmaceuticals

Phase 3

300

Rotterdam, Nijmegen

2026-06-03

Recruiting

Bleeding Disorder of Unknown Cause in the Netherlands

NCT07454161Hemorrhagic Disorders, Bleeding Disorder of Unknown Cause

Maastricht University Medical Center

Observational

500

Nijmegen, Maastricht, Veldhoven, Amsterdam, Groningen, Leiden, Rotterdam, Utrecht

2026-06-01

By invitation

Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3)

NCT07625488Coronary Artery Disease, Atherosclerosis

Radboud University Medical Center

Observational

250

Nijmegen, Utrecht

2026-05-31

Not yet open

Valvosoft Outcomes Registry for Real-World Evidence

NCT07520591Aortic Valve Disease, Aortic Stenosis, Severe, Aortic Valve Calcification, Ultrasound Therapy

Cardiawave SA

Observational

200

Nijmegen

2026-05-30

Recruiting

A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis

NCT07577856Colitis, Ulcerative

DrugsJNJ-78934804·Tremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

644

Amsterdam, Nijmegen, Tilburg, Utrecht

2026-05-23

Recruiting

A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease

NCT07577843Crohn Disease

DrugsJNJ-78934804·Tremfya·Guselkumab

Janssen Research & Development, LLC

Phase 3

460

Amsterdam, Nijmegen, Tilburg

2026-05-22

Recruiting

Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )

NCT07621718Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma

DrugsZoldonrasib·Leucovorin·Irinotecan·Adrucil

Revolution Medicines, Inc.

Phase 3

670

Nijmegen

2026-05-22

Recruiting

A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis

NCT07387549Primary Sclerosing Cholangitis

DrugElafibranor

Ipsen

Phase 3

350

Nijmegen, Amsterdam, Groningen, Leiden, Rotterdam, Utrecht

2026-05-14

Recruiting

Efficacy, Safety, and Tolerability of Zeleciment Basivarsen (DYNE-101) in Participants With Myotonic Dystrophy Type 1

NCT07486934Myotonic Dystrophy Type 1 (DM1), DM1, Myotonic Dystrophy, Steinert Disease

DrugZeleciment basivarsen

Dyne Therapeutics

Phase 3

150

Maastricht, Nijmegen

2026-05-14

Recruiting

Pembrolizumab Registry for Outcomes and Treatment Evaluation in Cervical Cancer

NCT07645625Cervical Cancer

University Medical Center Groningen

Phase 4

261

Amsterdam, Eindhoven, Enschede, Groningen, Leiden, Maastricht, Nijmegen, Rotterdam

2026-05-11

Recruiting

A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)

NCT07513376Non-small Cell Lung Cancer

DrugsPembrolizumab Formulated with Berahyaluronidase Alfa·Intismeran autogene

Merck Sharp & Dohme LLC

Phase 3

876

Harderwijk, Nijmegen, Amsterdam, Tilburg, Zwolle, Leeuwarden, Amersfoort, Groningen

2026-05-04

Recruiting

AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

NCT07611110Metastatic Castration-resistant Prostate Cancer

DrugsDeutenzalutamide·Xofigo·FPI-2265·Cabazitaxel

AstraZeneca

Phase 3

670

Amsterdam, Nijmegen

2026-05-04

Recruiting

Hypofractionated Definitive Chemoradiotherapy for Oesophageal Cancer

NCT07632079Locally Advanced Esophageal or GE Junction Cancer

DrugsPaclitaxel·Carboplatin

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Phase 2

Amsterdam, Apeldoorn, Groningen, Heerlen, Maastricht, Nijmegen

2026-04-28

Recruiting

A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)

NCT07419295Bladder Cancer

DrugsVinflunine·Sacituzumab tirumotecan·Docetaxel·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

590

Nijmegen, Maastricht, Amsterdam, Tilburg, Zwolle, Rotterdam, Utrecht

2026-04-23

Recruiting

A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease

NCT07499232Crohn Disease

DrugsRisankizumab·Guselkumab

Janssen Research & Development, LLC

Phase 3

530

Maastricht, Nijmegen, Tilburg

2026-04-21

Recruiting

A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression

NCT07546500Ovarian Cancer

DrugAzenosertib

K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Phase 3

420

Amsterdam, Groningen, Nijmegen

2026-04-17

Recruiting

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

NCT06451757Mitochondrial Diseases, Maternally Inherited Diabetes and Deafness (MIDD), Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS), Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation

DrugSonlicromanol

Khondrion BV

Phase 3

220

Nijmegen

2026-04-14

Recruiting

Affordable, Tailored Physical Therapy for Financially Vulnerable People With Trauma-related Injuries (AFTER-TRAUMA)

NCT07795216Quality of Life, PROMs

Radboud University Medical Center

Observational

153

Nijmegen

2026-04-02

Recruiting

TGW211 for Click-Cleavable Imaging in HER2-Positive Cancers.

NCT07009184HER2 Positive Solid Tumor

Radboud University Medical Center

Early Phase 1

Nijmegen

2026-04-02

Not yet open

Combining Latency Reversing Agents to Address the HIV Reservoir

NCT07384624HIV (Human Immunodeficiency Virus), HIV -1 Infection

DrugsTopiramate·Lenalidomide

Erasmus Medical Center

Phase 1/2

Amsterdam, Nijmegen, Rotterdam, Utrecht

2026-04

Recruiting

Clinical Impact of Using IMPROVE to Select Patients for Carotid Revascularisation

NCT07556887Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction, Stroke Ischemic, Atheroscleroses

Maastricht University Medical Center

Not applicable

613

Arnhem, Nijmegen, Heerlen, Maastricht, Amsterdam, Zwolle, Dordrecht, Rotterdam

2026-03-31

Recruiting

A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)

NCT07463183Colitis Ulcerative, Ulcerative Colitis

Merck Sharp & Dohme LLC

Phase 2

100

Nijmegen, Amsterdam

2026-03-24

Recruiting

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

NCT07361497Non-small Cell Lung Cancer (NSCLC)

DrugsPumitamig·Durvalumab

Bristol-Myers Squibb

Phase 3

850

Nijmegen, Breda, Amsterdam, Zwolle, Groningen, Tilburg

2026-03-16

Recruiting

Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer

NCT07472868Locally Advanced Rectal Carcinoma

DrugsFolfoxiri·Folfox·Leucovorin·Irinotecan

J. W. A. Burger

Phase 3

394

Arnhem, Nijmegen, Maastricht, Weert, 's-Hertogenbosch, Eindhoven, Helmond, Veldhoven

2026-03-16

Recruiting

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

NCT07351045Obesity or Overweight

Hoffmann-La Roche

Phase 3

2,000

Amsterdam, Nijmegen, Rotterdam, Utrecht, Zwolle

2026-03-16

Recruiting

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

NCT07361510Non-Small Cell Lung Cancer (NSCLC)

DrugsPumitamig·Pembrolizumab

Bristol-Myers Squibb

Phase 3

750

Nijmegen, Breda, 's-Hertogenbosch, Amersfoort, Deventer, Tilburg

2026-03-12

Recruiting

Mindfulness in Couples

NCT07433582Romantic Relationship Functioning

Behavioural Science Institute

Not applicable

426

Nijmegen

2026-03-03

Not yet open

Dilated Cardiomyopathy - Unknown Therapeutic Risk Reduction by Contempary Medication and Implantable Cardioverter-Defibrillators (DUTCH-ICD)

NCT07415642Sudden Cardiac Death

University Medical Center Groningen

Not applicable

720

Groningen, Nijmegen

2026-03-01

Recruiting

Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery

NCT07351149Acute Kidney Injury

Uppsala University

Observational

2,000

Nijmegen

2026-03-01

Recruiting

A Study of BI 3810944 in Patients With Advanced Cancer

NCT07224425Solid Tumours, Melanoma

Boehringer Ingelheim

Phase 1

Nijmegen

2026-02-24

Recruiting

Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS

NCT07197944Short Bowel Syndrome

DrugGlepaglutide

Zealand Pharma

Phase 3

Nijmegen

2026-02-11

Recruiting

First-Time-in-Human Study of GSK5471713 in Adults With mCRPC

NCT07332455Neoplasms, Prostate

GlaxoSmithKline

Phase 1/2

Amsterdam, Nijmegen

2026-02-10

Recruiting

A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma

NCT07258511Multiple Myeloma

DrugsRamantamig·Teclistamab

Janssen Research & Development, LLC

Phase 3

400

Amsterdam, Groningen, Nieuwegein, Nijmegen, Rotterdam, The Hague

2026-02-04

Recruiting

Study to Assess the Efficacy and Safety of Rina-S in Participants With Non-small Cell Lung Cancer

NCT07288177Non-small Cell Lung Cancer (NSCLC)

DrugRina-S

Genmab

Phase 2

240

Amsterdam, Leiden, Nijmegen

2026-01-30

Recruiting

A Study in Pediatric Participants With Congenital Adrenal Hyperplasia (Balance-CAH)

NCT07159841Congenital Adrenal Hyperplasia, Classic Congenital Adrenal Hyperplasia

DrugAtumelnant

Crinetics Pharmaceuticals Inc.

Phase 2/3

153

Nijmegen

2026-01-22

Active, closed

Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis

NCT07332091Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis

CSL Behring

Phase 2

Maastricht, Nijmegen

2026-01-22

By invitation

App-based Protein Support for Older Adults; Coaching Towards Healthy Ageing

NCT07415408Dietary Protein Intake

Radboud University Medical Center

Not applicable

140

Nijmegen

2026-01-12

Not yet open

Virtual Reality Intervention in Patients With Persistent Shoulder Pain

NCT07390227Rotator Cuff Syndrome, Shoulder Instability, Frozen Shoulder

HAN University of Applied Sciences

Not applicable

Nijmegen

2026-01-12

Recruiting

Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach

NCT07316296Parkinson's Disease (PD), Freezing of Gait, Freezing of Gait Symptoms in Parkinson Disease

DrugAtomoxetine

Radboud University Medical Center

Phase 3

Nijmegen

2026-01-01

Not yet open

RAPIDE: The Feasibility of a Hybrid Care Model

NCT06735404Diabetes Type 2, Heart Failure

Radboud University Medical Center

Not applicable

180

Nijmegen

2026-01

Recruiting

Study to Assess the Safety and Tolerability of Tafasitamab in Adult Participants With Primary Autoimmune Blood Cell Disorders

NCT07104565Immune Thrombocytopenia

Incyte Corporation

Phase 2

Amsterdam, Nijmegen, Rotterdam, Utrecht

2025-12-29

Recruiting

A Study to Assess Zipalertinib Versus Placebo in Participants With Early Stage NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection

NCT07128199Lung Cancer, Adjuvant, Post-surgical, EGFR

DrugZipalertinib

Taiho Oncology, Inc.

Phase 3

360

Harderwijk, Nijmegen, Leiden

2025-12-22

Recruiting

A Study to Evaluate the Safety and Effectiveness of the Rapidlink Device When Used in Patients Undergoing an Open Surgical Procedure to Repair the Aorta

NCT07078383Aortic Aneurysm, Aortic Aneurysm and Dissection, Aortic Diseases, Aneurysm of Aorta, Thoracic

Vascutek Ltd.

Not applicable

150

Nijmegen

2025-12-19

Recruiting

A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, in People With a Heart Attack

NCT07301034Myocardial Infarction

DrugZiltivekimab

Novo Nordisk A/S

Phase 3

332

Nijmegen, Rotterdam

2025-12-18

Recruiting

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

NCT07218380Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Neoplasm Metastasis

DrugsVepugratinib·Pembrolizumab

Eli Lilly and Company

Phase 3

450

Amsterdam, Breda, Nijmegen, Rotterdam

2025-12-12

Recruiting

Open and Closed Loop DTM SCS in Patients With PSPS Type 2: ENDLESS Study

NCT07211308Persistent Spinal Pain Syndrome Type 2, Failed Back Surgery Syndrome, Failed Neck Surgery Syndrome

Universitair Ziekenhuis Brussel

Observational

200

Arnhem, Nijmegen

2025-12-12

Recruiting

Short Course of Radiotherapy Prior to Surgery of Soft Tissue Sarcomas

NCT07071727Sarcoma of Soft Tissue, Sarcoma, Sarcoma, Soft Tissue

The Netherlands Cancer Institute

Not applicable

150

Amsterdam, Groningen, Leiden, Maastricht, Nijmegen

2025-12-11

Recruiting

A Study to Evaluate Atumelnant in Adults With Congenital Adrenal Hyperplasia

NCT07144163Congenital Adrenal Hyperplasia, Classic Congenital Adrenal Hyperplasia

DrugAtumelnant

Crinetics Pharmaceuticals Inc.

Phase 3

150

Leiden, Nijmegen

2025-12-11

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

NCT07155187Non-Small Cell Lung Cancer, c-MET

DrugsTelisotuzumab Adizutecan·Osimertinib

AbbVie

Phase 2/3

490

Nijmegen, Leiden, Rotterdam, Utrecht

2025-12-10

Active, closed

A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)

NCT07107945Chronic Kidney Disease

DrugDapagliflozin

Boehringer Ingelheim

Phase 3

135

Amsterdam, Groningen, Nijmegen, Rotterdam, Utrecht

2025-12-09

Recruiting

Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

NCT07214779Ovarian Cancer

DrugINCB123667

Incyte Corporation

Phase 3

466

Amsterdam, Groningen, Nijmegen, Utrecht

2025-12-09

Recruiting

A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

NCT07218926Gastrointestinal Neoplasms

DrugsIDRX-42·Sunitinib

GlaxoSmithKline

Phase 3

450

Amsterdam, Leiden, Nijmegen, Rotterdam

2025-12-03

Recruiting

LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

NCT07186101Ulcerative Colitis

DrugsZotemtegrast·Mirikizumab

Eli Lilly and Company

Phase 2

252

Nijmegen, Tilburg

2025-11-10

Recruiting

The TASTY-training Study

NCT07258589Oncological Patients, Tyrosine Kinase Inhibitor

University Medical Center Groningen

Not applicable

Amsterdam, Arnhem, Dirksland, Ede, Groningen, Nijmegen, Rotterdam, Scheemda

2025-11-10

Recruiting

Plant-based Versus Animal-based Oral Nutritional Supplements

NCT07399886Risk of Malnutrition

Radboud University Medical Center

Not applicable

Nijmegen, Maastricht

2025-11-10

Recruiting

TAO-Towards Optimal (Neo)Adjuvant Systemic Therapy of Stage III Triple-negative Breast Cancer

NCT06931769Breast Cancer

The Netherlands Cancer Institute

Observational

100

Enschede, Amsterdam, Breda, Deventer, Groningen, Maastricht, Nijmegen, Rotterdam

2025-11-06

Recruiting

A Study on How the Immune System Responds to Sepsis and Its Long-term Effects

NCT07273344Sepsis

Radboud University Medical Center

Observational

400

Nijmegen

2025-11-03

Recruiting

Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease

NCT07223593Peripheral Arterial Disease

DrugOrforglipron

Eli Lilly and Company

Phase 3

1,205

Dordrecht, Eindhoven, Nijmegen

2025-10-31

Recruiting

A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)

NCT06405087Ulcerative Colitis, Crohn's Disease

DrugVedolizumab

Takeda

Phase 3

Nijmegen

2025-10-27

Recruiting

Individualised Endometrial Cancer Risk Stratification by Bayesian Prediction Model (ENDORISK), Optimizing Clinical Implementation

NCT07200466Endometrial Cancer

Radboud University Medical Center

Not applicable

735

Arnhem, Doetinchem, Ede, Nijmegen, Winterswijk, 's-Hertogenbosch, Breda, Eindhoven

2025-10-23

Recruiting

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

NCT07213791Ovarian Neoplasms, Breast Neoplasms, Pancreatic Intraductal Neoplasms, Colorectal Neoplasms

Eli Lilly and Company

Phase 1

340

Amsterdam, GE Rotterdam, Maastricht, Nijmegen, Utrecht

2025-10-22

Recruiting

A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

NCT07219173Asthma

DrugBrenipatide

Eli Lilly and Company

Phase 2

531

Almere Stad, Breda, Nijmegen, Rotterdam, Zutphen, Zwolle

2025-10-22

Recruiting

A Non-interventional Study of Participants With BPDCN Treated With Chemotherapy

NCT07785180Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Stemline Therapeutics, Inc.

Observational

140

Amsterdam, Groningen, Nijmegen

2025-10-17

Recruiting

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

NCT07165028Metabolic Dysfunction-Associated Steatotic Liver Disease

DrugsRetatrutide·Tirzepatide

Eli Lilly and Company

Phase 3

4,500

's-Hertogenbosch, Amsterdam, Nijmegen, Rotterdam, Utrecht, Zwolle

2025-10-15

Recruiting

EPIK-P4: A Phase II Single-arm Study to Assess the Efficacy, Safety and Pharmacokinetics of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum (PROS)

NCT06997588PIK3CA-related Overgrowth Spectrum (PROS)

DrugAlpelisib

Novartis Pharmaceuticals

Phase 2

140

Nijmegen

2025-10-09

Recruiting

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

NCT07184996Ulcerative Colitis

DrugDuvakitug

Sanofi

Phase 3

980

Nijmegen

2025-10-08

Recruiting

A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

NCT07023614Non-obstructive Hypertrophic Cardiomyopathy

Imbria Pharmaceuticals, Inc.

Phase 2

165

Amsterdam-Zuidoost, Leiden, Nijmegen, Rotterdam

2025-10-06

Recruiting

A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease

NCT07196722Crohn Disease

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 2/3

1,092

Amsterdam, Maastricht, Nijmegen, Rotterdam

2025-10-03

Not yet open

The Impact of Artificial Intelligence on Dentists' Decision-Making Process During Caries Detection

NCT07027189Artificial Intelligence (AI) in Diagnosis, Artificial Intelligence Supported Image Reviewing

Radboud University Medical Center

Not applicable

Nijmegen

2025-10-02

Recruiting

Obinutuzumab Induced Decreases of PLA2R Antibodies in Membranous Nephropathy: a Pilot Study

NCT07163611Membranous Nephropathy - PLA2R Induced

DrugObinutuzumab administration

Radboud University Medical Center

Phase 2/3

Nijmegen

2025-10-01

Active, closed

A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

NCT07196748Colitis, Ulcerative

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

896

Amsterdam, Maastricht, Nijmegen

2025-10-01

Recruiting

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

NCT07184931Crohn's Disease

DrugDuvakitug

Sanofi

Phase 3

980

Amsterdam, Christchurch, Lower Hutt, Nijmegen, Tauranga, Tilburg, Wellington

2025-10-01

Recruiting

Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)

NCT07204275Primary Membranous Nephropathy

DrugsPovetacicept·Tacrolimus

Vertex Pharmaceuticals Incorporated

Phase 2/3

176

Amsterdam, Nijmegen

2025-09-30

Recruiting

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

NCT07028853Metastatic Castration Sensitive Prostate Cancer (mCSPC), Hormone Sensitive Prostate Cancer, Prostate Cancer, Cancer of the Prostate

DrugsMevrometostat·Xtandi·Enzalutamide

Pfizer

Phase 3

1,000

Nijmegen, Hilversum, Delft

2025-09-28

Recruiting

A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

NCT07053423Chronic Obstructive Pulmonary Disease

DrugDupilumab

Sanofi

Phase 4

218

Groningen, Hoofddorp, Nijmegen, Rotterdam

2025-09-22

Recruiting

Shorter Weaning From Invasive Ventilation With Levosimendan

NCT07105202Mechanical Ventilation, Weaning Failure

DrugLevosimendan

Radboud University Medical Center

Phase 4

250

Arnhem, Nijmegen, 's-Hertogenbosch, Eindhoven, Rotterdam

2025-09-17

Recruiting

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

NCT07190222Chronic Obstructive Pulmonary Disease

DrugLunsekimig

Sanofi

Phase 3

942

Arnhem, Breda, Dordrecht, Nijmegen, The Hague, Zutphen

2025-09-17

Recruiting

Detection of Minimal Residual Disease Post-prostatectomy

NCT07334275Prostate Cancer

Radboud University Medical Center

Observational

Nijmegen

2025-09-16

Recruiting

REDO-JAK: Dose Reduction of Janus Kinase Inhibitors in Patients With Inflammatory Rheumatic Diseases

NCT07160231Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Axial Spondyloarthritis (AxSpA)

Sint Maartenskliniek

Phase 4

200

Nijmegen, Maastricht, Tilburg, Enschede, Zwolle, Rotterdam

2025-09-15

Recruiting

A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants With High Risk Non-Muscle-Invasive Bladder Cancer

NCT06919965Non-Muscle Invasive Bladder Neoplasms

DrugsErdafitinib·Mitomycin C·Gemcitabine

Janssen Research & Development, LLC

Phase 3

220

Nijmegen, Rotterdam, Utrecht

2025-09-10

Recruiting

Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

NCT07011719Metastatic Clear Cell Renal Cell Carcinoma, Advanced Clear Cell Renal Cell Carcinoma

DrugsCasdatifan·Cabozantinib

Arcus Biosciences, Inc.

Phase 3

720

Amsterdam, Maastricht, Nijmegen, Rotterdam, Utrecht, Zwolle

2025-09-08

Recruiting

A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT06973187Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsTacabrutideg·Pirtobrutinib

BeOne Medicines

Phase 3

500

Dordrecht, EJ Eindhoven, Gouda, Groningen, Nijmegen, Utrecht

2025-09-04

Recruiting

PEEP-induced Effects on Respiratory dRivE and EFfort

NCT07203781ARDS (Moderate or Severe), Acute Hypoxemic Respiratory Failure

Radboud University Medical Center

Not applicable

Nijmegen

2025-09-02

Recruiting

A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)

NCT07164443Metastatic Castration-resistant Prostatic Neoplasms

DrugsJNJ-87189401·Pasritamig

Janssen Research & Development, LLC

Phase 3

1,203

Delft, Groningen, Hilversum, Hoofddorp, Maastricht, Nijmegen, Rotterdam, Zwolle

2025-09-02

Recruiting

Respiratory Muscles in End-stage Lung Disease: Pathophysiological Processes & Clinical Consequences

NCT06935825COPD

University Medical Center Groningen

Observational

Amsterdam, Groningen, Nijmegen, Rotterdam

2025-09-01

Recruiting

Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage

NCT06993142Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases

Radboud University Medical Center

Not applicable

600

Nijmegen

2025-09-01

Recruiting

A Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon 45 Skipping to Evaluate the Safety and Efficacy of ENTR-601-45

NCT07038824Duchenne Muscular Dystrophy (DMD)

DrugENTR-601-45

Entrada Therapeutics, Inc.

Phase 1/2

Leiden, Nijmegen

2025-08-30

Recruiting

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

NCT06982521PIK3CA Mutation, HER2- Negative Breast Cancer, Hormone Receptor Positive Tumor, Breast Cancer

DrugsCapivasertib·Fulvestrant

Relay Therapeutics, Inc.

Phase 3

540

Maastricht, Nijmegen, Sittard, The Hague

2025-08-26

Recruiting

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.

NCT06925321Invasive Mold Infections

DrugFosmanogepix

Basilea Pharmaceutica

Phase 3

234

Nijmegen, Rotterdam, Utrecht

2025-08-26

Recruiting

A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors

NCT07169734Cervical Squamous Cell Carcinoma, Squamous Non-small-cell Lung Cancer, Colorectal Cancer, Intrahepatic Cholangiocarcinoma

Alentis Therapeutics AG

Phase 1/2

180

Amsterdam, Nijmegen, Rotterdam

2025-08-26

Recruiting

Cue2Walk, Cost-effectiveness of Automated Freezing Detection and Provision of External Cues in Comparison to Usual Care in People With Parkinson's Disease

NCT06416345Parkinson Disease

Amsterdam UMC, location VUmc

Not applicable

Nijmegen, Amsterdam

2025-08-22

Recruiting

Early Versus Delayed Trial Without Catheter in Men With Acute Urinary Retention.

NCT07283484Acute Urinary Retention, Benign Prostate Obstruction, Benign Prostate Hyperplasia, Benign Prostate Hypertrophy(BPH)

Liselot Ribbert

Not applicable

478

Harderwijk, Nijmegen, Heerlen, Maastricht, Eindhoven, Amsterdam, Hoofddorp, Hengelo

2025-08-21

Recruiting

Transtympanic STS Against Cisplatin-induced SNHL: the SOUND Trial

NCT07281508Cisplatin-related Hearing Loss

The Netherlands Cancer Institute

Phase 3

100

Amsterdam, Leiden, Rotterdam, Utrecht, Nijmegen

2025-08-14

Recruiting

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

NCT06952803Prostate Cancer

DrugsPrednisolone/prednisone·Saruparib·Abiraterone

AstraZeneca

Phase 3

700

Hilversum, Hoofddorp, Maastricht, Nijmegen, Roosendaal

2025-08-06

Active, closed

A Study to Evaluate Tobevibart+Elebsiran Versus Bulevirtide in Chronic HDV Infection

NCT07142811Viral Hepatitis

DrugsElebsiran·Tobevibart·Bulevirtide

Vir Biotechnology, Inc.

Phase 2

100

Amsterdam, Nijmegen, Rotterdam

2025-08-05

Recruiting

SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY)

NCT07021495Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa (HS), Psoriasis (PsO), Atopic Dermatitis (AD)

Leiden University Medical Center

Observational

840

Nijmegen, Maastricht, Amsterdam, Groningen, Leiden, Rotterdam, Utrecht

2025-07-29

Recruiting

A Clinical Study of MK-8294 in Participants With Advanced Solid Tumors (MK-8294-001)

NCT07030712Metastatic Neoplasm

Merck Sharp & Dohme LLC

Phase 1

Nijmegen, Amsterdam

2025-07-23

Recruiting

Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis

NCT06950385Familial Adenomatous Polyposis (FAP)

Rapamycin Holdings Inc.

Phase 3

168

Amsterdam, Nijmegen

2025-07-18

Recruiting

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

NCT06765109Non-small Cell Lung Cancer, Anaplastic Lymphoma Kinase-positive

DrugsNeladalkib·Alectinib

Nuvalent Inc.

Phase 3

450

Amsterdam, Nijmegen, Utrecht

2025-07-17

Recruiting

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

NCT06997497Colon Adenocarcinoma, Rectal Adenocarcinoma

DrugsLeucovorin/levofolinate calcium·Bevacizumab biosimilar·Calderasib·Mvasi

Merck Sharp & Dohme LLC

Phase 3

477

Nijmegen, Breda, Amsterdam, Rotterdam

2025-07-16

Recruiting

A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy

NCT06963827Kidney Disease

DrugMezagitamab

Takeda

Phase 3

347

Amsterdam, Leiden, Nieuwegein, Nijmegen, Utrecht

2025-07-15

Recruiting

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

NCT07013474COVID-19 Infection

DrugsIbuzatrelvir·Veklury·Remdesivir

Pfizer

Phase 3

300

Nijmegen, Rotterdam

2025-07-14

Recruiting

A Phase 1b/2a Trial to Evaluate Invobenitug Also Known as Procizumab (PCZ; AK1967) in Critical Cardiovascular Care.

NCT06832722Shock, Cardiogenic

4TEEN4 Pharmaceuticals GmbH

Phase 1/2

Nijmegen

2025-07-13

Active, closed

A Study of JSB462 (Luxdegalutamide) Plus Lutetium (177Lu) Vipivotide Tetraxetan in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)

NCT07047118Prostatic Cancer, Castration-Resistant

DrugsLuxdegalutamide·Lu-PSMA

Novartis Pharmaceuticals

Phase 2

138

Nijmegen, Hoofddorp

2025-07-03

Recruiting

Master Protocol of TCR-modified T Cell Therapy Targeting HLA-restricted KRAS Antigen Administered in Adult Patients With Metastatic or Locally Advanced PDAC

NCT07145450PDAC

Anocca AB

Phase 1/2

Amsterdam, Nijmegen

2025-07-03

Recruiting

A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)

NCT06863272Castration-Resistant Prostatic Cancer, Metastasis

DrugsOpevesostat·Ifinatamab Deruxtecan·Abiraterone·Enzalutamide

Merck Sharp & Dohme LLC

Phase 1/2

360

Ede, Nijmegen, Drachten

2025-07-03

Recruiting

HAKA: Routine Follow-Up at 1 Year After Hip- or Knee Arthroplasty: Wasting Resources or Appropriate Healthcare?

NCT06971757Hip Arthroplasty, Total, Knee Arthroplasty, Total

JointResearch

Not applicable

1,000

Amsterdam, Breda, Deventer, Goes, Groningen, Hilversum, Nijmegen, Terneuzen

2025-07-01

Recruiting

Smart Pill for Measuring Gut Health in Colon Inflammation and Colon Cancer

NCT07046468Ulcerative Colitis (UC), Colorectal Cancer (CRC)

Radboud University Medical Center

Observational

Nijmegen

2025-07-01

Active, closed

Rezafungin for Treatment of Chronic Pulmonary Aspergillosis (CPA) in Adults With Limited Treatment Options

NCT06794554Chronic Pulmonary Aspergillosis

Mundipharma Research Limited

Phase 2

Nijmegen

2025-06-30

Recruiting

A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy

NCT06979375Heart Failure

DrugCDR132L

Novo Nordisk A/S

Phase 2

200

Amsterdam, Heerlen, Nijmegen, Rotterdam, Venlo

2025-06-30

By invitation

Global Open-Label Extension Study of Del-desiran for the Treatment of DM1

NCT07008469Myotonic Dystrophy Type 1, DM1, Myotonic Dystrophy, Myotonia

Avidity Biosciences, Inc.

Phase 3

199

Maastricht, Nijmegen

2025-06-26

Recruiting

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

NCT06937099Crohn's Disease, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

290

Amsterdam, Nijmegen, Rotterdam, Utrecht

2025-06-26

Recruiting

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

NCT06937086Ulcerative Colitis, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

350

Amsterdam, Nijmegen, Rotterdam, Utrecht

2025-06-26

Recruiting

Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation

NCT06959095Pulmonary Disease, Chronic Obstructive

DrugDepemokimab

GlaxoSmithKline

Phase 3

981

Zutphen, Breda, Zwolle, Deventer, Enschede, Harderwijk, Hoofddorp, Nijmegen

2025-06-20

Recruiting

STV Analysis Versus Visual Evaluation of Cardiotocography in FGR

NCT06010238Fetal Growth Retardation

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Not applicable

800

Groningen, Amsterdam, Maastricht, Nijmegen, Rotterdam, Zwolle

2025-06-18

Active, closed

A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab

NCT06880744Ulcerative Colitis

DrugsRisankizumab·Vedolizumab

AbbVie

Phase 3

573

Nijmegen, Tilburg, Amsterdam, Dordrecht, Rotterdam

2025-06-17

Recruiting

Lifestyle Intervention for Symptoms of Depression wIth App Support in General Practice

NCT07022184Depressive/Anxiety Symptoms, Depressive Disorder

Radboud University Medical Center

Not applicable

216

Nijmegen, Amsterdam, Groningen

2025-06-17

Recruiting

A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

NCT07038200Facioscapulohumeral Muscular Dystrophy, FSHD, FSHD - Facioscapulohumeral Muscular Dystrophy, FSHD1

DrugDel-brax

Avidity Biosciences, Inc.

Phase 3

200

Leiden, Nijmegen

2025-06-10

Recruiting

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

NCT06340568Endometrial Cancer

DrugsDoxorubicin·Docetaxel·Paclitaxel

BioNTech SE

Phase 3

480

Nijmegen, Rotterdam

2025-06-10

Active, closed

A Study to Learn More About the Effects and Long-Term Safety of Omaveloxolone (BIIB141) in Children and Teens With Friedreich's Ataxia

NCT06953583Friedreich Ataxia

DrugsOmaveloxolone·Skyclarys

Biogen

Phase 3

255

Nijmegen

2025-06-09

Recruiting

The TASTY-steering Study

NCT07258563Metastatic Triple Negative Breast Cancer, Metastatic Testicular Cancer, Stage II-IV Diffuse Large B Cell Lymphoma

University Medical Center Groningen

Not applicable

201

Amsterdam, Arnhem, Dirksland, Ede, Groningen, Nijmegen, Rotterdam, Scheemda

2025-06-06

Recruiting

Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)

NCT06891443Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Sensation Disorders

DrugSepofarsen

Laboratoires Thea

Phase 3

Nijmegen

2025-06-04

Recruiting

Timely Integration of Palliative Care in Oncology Care for Patients Referred for Palliative Radiotherapy on Bone Metastases: A Randomized Trial

NCT06805396Bone Metastases in Subjects With Advanced Cancer, Radiotherapy

Roxanne Gal

Phase 2

246

Amersfoort, Gouda, Leiden, Nijmegen

2025-06-02

Recruiting

A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

NCT06901531Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

DrugsZolbetuximab·Adrucil·Capecitabine·Oxaliplatin

Astellas Pharma Global Development, Inc.

Phase 3

500

Leeuwarden, Nijmegen

2025-05-22

Recruiting

Perioperative Durvalumab With Neoadjuvant ddMVAC in Patients With Muscle-Invasive Bladder Cancer (NIAGARA-2)

NCT06960577Urinary Bladder Neoplasms, Immune Checkpoint Inhibitors, Methotrexate, Vinblastine

DrugsVinblastine·Methotrexate·Doxorubicin·Durvalumab

AstraZeneca

Phase 2

150

Amsterdam, Nijmegen, Rotterdam

2025-05-15

Recruiting

Sequential Imaging of Suspicion of Prostate Cancer Reducing Overdiagnosis and Unnecessary Biopsy With Timely Diagnosis of Significant Cancer

NCT07180381Prostate Cancer

St. Antonius Hospital

Not applicable

503

Emmen, Arnhem, Nijmegen, Amsterdam, Rotterdam, Nieuwegein

2025-05-14

Recruiting

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

NCT06925737Prostate Cancer, Prostatic Neoplasms

DrugsIfinatamab Deruxtecan·Prednisolone·Prednisone·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

1,440

Nijmegen, Maastricht, Venlo, Amsterdam, Hilversum, Hoofddorp, Hengelo, Rotterdam

2025-05-13

Active, closed

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)

NCT06925750Pulmonary Arterial Hypertension

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 2

130

Nijmegen, Nieuwegein

2025-05-12

Recruiting

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

NCT06881784NSCLC (Non-small Cell Lung Cancer), Non-Small Cell Lung Cancer, NSCLC, NSCLC (Non-small Cell Lung Carcinoma)

DrugsCetuximab·Docetaxel

Revolution Medicines, Inc.

Phase 3

590

Amsterdam, Rotterdam, Groningen, Maastricht, Nijmegen

2025-05-06

Active, closed

Pediatric Expansion Study of the Sentio System

NCT06976086Hearing Loss, Conductive, Hearing Loss, Mixed, Single Sided Deafness

Oticon Medical

Not applicable

Groningen, Nijmegen

2025-04-30

Recruiting

Implementation of Indocyanine Green to Identify Sentinel Lymph Nodes During Surgery for Breast Cancer

NCT07146295Breast Cancer, Sentinel Lymph Node Biopsy (SLNB), Sentinel Lymph Node Detection, Sentinel Lymph Node

DrugIndocyanine Green

Isabelle Henskens

Not applicable

1,760

Alkmaar, Hengelo, Hoofddorp, Hoorn, Leiden, Nijmegen, Utrecht

2025-04-18

Recruiting

LSD to Improve Cluster Headache Impact Trial

NCT05477459Chronic Cluster Headache

Radboud University Medical Center

Phase 2

Leiden, Nijmegen

2025-04-16

Recruiting

OligoCare TwiCs (Trials Within Cohorts) Trial Comparing Acute Toxicity in Single-fraction vs Multiple-fraction SBRT for Metastasis-directed Treatment (SPRINT)

NCT06462963Breast Cancer, Prostate Cancer, NSCLC, Colorectal Cancer

European Organisation for Research and Treatment of Cancer - EORTC

Not applicable

302

Deventer, Nijmegen

2025-04-15

Not yet open

Inpatient Endoscopy Procedure Planning Delays and Impact on Length of Stay and 30-day Readmission

NCT05798065Inpatient Endoscopy Delay, Readmission, Prolonged Hospital Stay

Radboud University Medical Center

Observational

3,700

Nijmegen

2025-04-01

Recruiting

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

NCT06989112Endometrial Cancer

DrugsRilvegostomig·Taxotere·Paraplatin·Trastuzumab deruxtecan

AstraZeneca

Phase 3

600

Amsterdam, Leiden, Nijmegen, Rotterdam

2025-03-27

Recruiting

A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

NCT06644781Esophageal Squamous Cell Carcinoma

DrugsIfinatamab Deruxtecan·Irinotecan·Docetaxel·Paclitaxel

Daiichi Sankyo

Phase 3

510

Amsterdam, Nijmegen, Rotterdam

2025-03-27

Recruiting

A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)

NCT06818643Advanced Solid Tumors, Malignant Neoplasm

DrugMK-3120

Merck Sharp & Dohme LLC

Phase 1/2

270

Nijmegen, Amsterdam, Rotterdam

2025-03-25

Recruiting

A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy

NCT06854640Sepsis, Coagulopathy

DrugBAY3389934

Bayer

Phase 1

Nijmegen, 's-Hertogenbosch, Enschede, Rotterdam

2025-03-12

Recruiting

A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

NCT06615479Relapsed or Refractory Multiple Myeloma (RRMM)

DrugsArlo-cel·Carfilzomib·Pomalidomide·Daratumumab

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 3

440

Nijmegen, Maastricht, Amsterdam, Utrecht

2025-03-12

Recruiting

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

NCT06641466Menstrual Migraine

DrugRimegepant

Pfizer

Phase 3

723

Nijmegen, Zwolle, Leiden

2025-03-11

By invitation

Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0

NCT06823115Acute Kidney Injury, Fluid Overload, Prematurity Complications, Risk Factors

Indiana University

Observational

8,000

Nijmegen

2025-03-01

Recruiting

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

NCT06731478Gastric Cancer, Gastroesophageal Junction Cancer

DrugsTrastuzumab deruxtecan·Trastuzumab·Keytruda·Pembrolizumab

Daiichi Sankyo

Phase 3

726

Amsterdam, Leeuwarden, Nijmegen, Rotterdam, Tilburg, Utrecht

2025-02-27

Recruiting

Tasquinimod in Patients with Myelofibrosis Refractory to or Intolerant for JAK2 Inhibition

NCT06605586Myelofibrosis

Stichting Hemato-Oncologie voor Volwassenen Nederland

Phase 1/2

Amsterdam, Groningen, Nijmegen, Rotterdam, Utrecht

2025-02-20

Active, closed

Post Market Registry for GORE® TAG® Thoracic Branch Endoprosthesis

NCT06507865Aneurysm, Dissection, Aortic, TAA Thoracoabdominal Aortic Aneurysm, Thoracic Aortic Aneurysm

W.L.Gore & Associates

Observational

155

Amsterdam, Nijmegen

2025-02-20

Recruiting

Effectiveness of Decision Support for Cardiovascular Risk Management in People With Cardiovascular Disease

NCT06871514Atherosclerotic Cardiovascular Diseases, Shared-decision Making

dr.Frank L.J. Visseren

Not applicable

1,200

Alkmaar, Amersfoort, Deventer, Ede, Nijmegen, The Hague, Utrecht

2025-02-18

Recruiting

A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

NCT06810505Chronic Migraine

DrugAtogepant

AbbVie

Phase 3

420

Nijmegen, The Hague

2025-02-13

Active, closed

REdo Transcatheter Aortic VALVE Implantation for the Management of Transcatheter Aortic Valve Failure

NCT06557798Aortic Valve Stenosis

The Leeds Teaching Hospitals NHS Trust

Observational

550

Breda, Maastricht, Nijmegen, Rotterdam

2025-02-04

Recruiting

A Prospective Randomised Study of Treatment Selection Based on Epigenetic Markers Versus Standard of Care Treatment Selection in Adults With CROHN's Disease

NCT07363044Crohn Disease (CD)

Alimentiv Inc.

Not applicable

378

Almere Stad, Amsterdam, Eindhoven, Maastricht, Nieuwegein, Nijmegen, Tilburg, Utrecht

2025-02-01

Not yet open

Immuno-pet IMaging ResPonses AdministeRed Immune CheckpoiNt InhibiTor

NCT06218069NSCLC

DrugSasanlimab

Radboud University Medical Center

Phase 2/3

Nijmegen

2025-02

Recruiting

DIGITAL-KNEE Study: Adequately Diagnosing Total Knee Arthroplasty Loosening by Evaluating the AtMoves Knee System in a Routine Clinical Setting

NCT06839807Aseptic Loosening, Aseptic Loosening of Prosthetic Joint, Aseptic Loosening of Orthopaedic Hardware, Knee Arthroplasty, Total

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Not applicable

124

Nijmegen, Heerlen, Breda, Amsterdam, Hengelo, Alkmaar, Tilburg

2025-02

Not yet open

Elective Adhesiolysis vs. a Wait-and-see Policy to Prevent Recurrences After Conservative Treatment of Adhesive Small Bowel Obstruction

NCT06777446Adhesive Small Bowel Obstruction

Radboud University Medical Center

Not applicable

380

Almelo, Amsterdam, Boxmeer, Harderwijk, Maastricht, Nijmegen, Roermond, Rotterdam

2025-02

Recruiting

Trial Comparing Cataract Surgery With Triple-DMEK in Patients With Cataract and Fuchs Endothelial Corneal Dystrophy

NCT06425666Cataract Surgery, Cataract and Fuchs Endothelial Corneal Dystrophy

University of Cologne

Not applicable

120

Nijmegen

2025-01-24

Recruiting

A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease

NCT06100289Ulcerative Colitis, Crohn's Disease

DrugVedolizumab

Takeda

Phase 3

Nijmegen

2025-01-22

Recruiting

High Intensity Interval Training in Patients With a Right Ventricle to Pulmonary Artery Conduit

NCT06771687Congenital Heart Disease, Truncus Arteriosus, Pulmonary Atresia, Tetralogy of Fallot

Erasmus Medical Center

Not applicable

Nijmegen, Rotterdam

2025-01-16

Recruiting

The Impact of Metastatic Directed Radiotherapy (MDRT) on Oligoprogressive Castration Resistant Prostate Cancer (CRPC)

NCT07038304Prostate Cancer (Adenocarcinoma), OligoProgressive Metastatic Disease, Castration Resistant Metastatic Prostate Cancer, Radiotherapy

University Medical Center Groningen

Phase 2

Groningen, Nijmegen

2025-01-03

Recruiting

A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

NCT06227910Crohn's Disease

DrugsVedolizumab·Upadacitinib

Takeda

Phase 3

396

Amsterdam, Nijmegen, Rotterdam, Tilburg

2025-01-02

Recruiting

The Effect of ColcHicine on the Incidence of Knee or Hip Replacements

NCT06578182Osteoarthritis, Knee, Osteoarthritis, Hip

DrugColchicine

Sint Maartenskliniek

Phase 3

1,410

Nijmegen

2025-01-01

Recruiting

Clinical Trial to Compare Two Surgical Approaches to the Cochlea

NCT06453343Cochlear Implants, Hearing Loss, Sensorineural

Radboud University Medical Center

Not applicable

Nijmegen

2025-01-01

Active, closed

Factors Determining the Efficacy of Botulinum Toxin for Arm Tremor in Dystonia

NCT06411028Dystonic Tremor Syndrome

DrugBotulinum toxin

Radboud University Medical Center

Phase 4

Nijmegen

2025-01-01

Not yet open

Automated Cardiac Arrest Detection and Alerting in Daily Life

NCT06692374Cardiac Arrest (CA), Sudden Death, Cardiac

Radboud University Medical Center

Observational

200

Nijmegen

2025-01-01

Recruiting

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

NCT06750094Colorectal Neoplasms

DrugsLeucovorin calcium/Levoleucovorin·Amivantamab·Erbitux·Avastin

Janssen Research & Development, LLC

Phase 3

700

Amersfoort, Amsterdam, Nijmegen, Rotterdam, Tilburg

2024-12-12

Recruiting

A Study to Learn More About the Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Ataxia Who Are Prescribed it by Their Own Doctors

NCT06623890Friedreich Ataxia

DrugsOmaveloxolone·Skyclarys

Biogen

Observational

300

Nijmegen

2024-12-12

Active, closed

Study Evaluating AZD7798 for Treatment in Crohn's Disease Patients With an Ileostomy

NCT06681324Crohn's Disease

DrugAZD7798

AstraZeneca

Phase 2

Amsterdam, Nijmegen

2024-12-11

Active, closed

Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

NCT06627179Retinitis Pigmentosa (RP), Usher Syndrome Type 2, Deaf Blind, Retinal Disease

Laboratoires Thea

Phase 2

Amsterdam, Nijmegen, Rotterdam

2024-12-11

Active, closed

Phase 3 Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Participants With Progressive Metastatic Castration-Resistant Prostate Cancer (XALute)

NCT06691984Metastatic Castration-resistant Prostate Cancer

DrugsXaluritamig·Cabazitaxel·Abiraterone·Enzalutamide

Amgen

Phase 3

707

Amsterdam, Delft, Groningen, Nijmegen, Rotterdam

2024-12-09

Active, closed

A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies

NCT06645886Hematologic Malignancies, Adult

DrugsKQB198·Dasatinib

Kumquat Biosciences Inc.

Phase 1

Nijmegen

2024-12-09

Recruiting

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

NCT06667908Carcinoma, Non-Small-Cell Lung

DrugsJNJ-90301900·Durvalumab

Johnson & Johnson Enterprise Innovation Inc.

Phase 2

130

Amsterdam, Nijmegen

2024-12-06

Recruiting

Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor

NCT06472245Patients With Non-Small Cell Lung Cancer

DrugsTedopi·Docetaxel

OSE Immunotherapeutics

Phase 3

363

Nijmegen, Rotterdam, Groningen

2024-12-03

Recruiting

Restrictive Versus Liberal Thresholds for RBC Transfusion in ECMO

NCT06560164Transfusion, Red Blood Cell, Extracorporeal Membrane Oxygenation, Anemia

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Not applicable

526

Enschede, Nijmegen, Maastricht, Amsterdam, Groningen, Leiden, Rotterdam, Nieuwegein

2024-11-26

Active, closed

Trial to Evaluate Acasunlimab and Pembrolizumab Combination Superiority Over Standard of Care Docetaxel in Non-Small Cell Lung Cancer (ABBIL1TY NSCLC-06)

NCT06635824PD-L1-positive, Locally Advanced (Unresectable Stage IIIB/C) or Metastatic NSCLC

DrugsDocetaxel·Pembrolizumab

Genmab

Phase 3

191

Amsterdam, Harderwijk, Heerlen, Leiden, Nijmegen, Rotterdam, Utrecht, Zwolle

2024-11-25

Not yet open

Early Artificial Lateral Prosthesis

NCT06705985Post-Meniscectomy Pain Syndrome

ATRO Medical B.V.

Not applicable

Nijmegen

2024-11-21

Recruiting

COgnitive Dynamics in Early Childhood

NCT06330090Cognitive Change

Radboud University Medical Center

Observational

600

Nijmegen

2024-11-18

Recruiting

Methylphenidate in KBG Syndrome: N-of-1 Series

NCT06465641Kbg Syndrome, ADHD - Combined Type

DrugMethylphenidate Hydrochloride

Radboud University Medical Center

Phase 4

Nijmegen

2024-11-13

Active, closed

An Integrated and Personalized Lifestyle Approach for People With Parkinson's Disease

NCT06669455Parkinson Disease

Radboud University Medical Center

Not applicable

256

Nijmegen

2024-11-12

Active, closed

A Study of Radiation Dosimetry, Safety, and Tolerability of Extended Lutetium (177Lu) Vipivotide Tetraxetan Treatment in Chemo-naïve Adults With Metastatic Castration-resistant Prostate Cancer: RADIOpharmaceutical DOSimetry Evaluation (RADIODOSE) Study

NCT06531499Metastatic Castration-Resistant Prostate Cancer

DrugLu-PSMA

Novartis Pharmaceuticals

Phase 1

110

Nijmegen

2024-11-11

By invitation

Efficacy of Endothelin Receptor Antagonism in Coronary Artery Spasm

NCT06432452Coronary Spasm

DrugBosentan

Radboud University Medical Center

Phase 2/3

100

Eindhoven, Rotterdam, Nijmegen, Utrecht

2024-11-11

Active, closed

A Study on Safety and Effectiveness of Long-term Treatment With Vamorolone in Boys With Duchenne Muscular Dystrophy

NCT06713135Duchenne Muscular Dystrophy

DrugVamorolone

Santhera Pharmaceuticals

Phase 4

Leiden, Nijmegen

2024-11-10

By invitation

10-year Follow-up of the Ponto Wide-implant

NCT06772714Survival of the Ponto Wide Implant

University Medical Center Nijmegen

Observational

Nijmegen

2024-11-04

Active, closed

RELIEF-pathway in Patients With Upper Abdominal Pain

NCT06002516Abdominal Pain, Gallstone; Colic, Dyspepsia, Irritable Bowel Syndrome

Radboud University Medical Center

Not applicable

471

Nijmegen

2024-11-01

Recruiting

Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

NCT06456593Moderately to Severely Active Crohn Disease

DrugObefazimod

Abivax S.A.

Phase 2

212

Amsterdam, Maastricht, Nijmegen, Tilburg, Uden

2024-10-30

Active, closed

A Study of Mosliciguat in PH-ILD

NCT06635850Pulmonary Hypertension, Interstitial Lung Disease, Lung Diseases, Vascular Diseases

DrugMosliciguat

Pulmovant, Inc.

Phase 2

135

Nijmegen, Amsterdam

2024-10-29

Recruiting

Viewing Strategy Training in Children With (Cerebral) Visual Impairment

NCT05600140Vision Disorders, Vision, Low

Royal Dutch Visio

Not applicable

Nijmegen

2024-10-25

Recruiting

A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

NCT06629779Metastatic Castration-Resistant Prostate Cancer

DrugsMevrometostat·Xtandi·Enzalutamide

Pfizer

Phase 3

900

Nijmegen, Amsterdam, Leeuwarden, Schiedam

2024-10-22

Recruiting

Perioperative SDD to Prevent Infectious Complications After Esophagectomy

NCT05865743Esophageal Cancer

Radboud University Medical Center

Phase 3

854

Nijmegen

2024-10-21

Recruiting

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

NCT06623422Carcinoma, Non-Small-Cell Lung

DrugsIntismeran autogene·Platinol-AQ·Paraplatin·Taxol

Merck Sharp & Dohme LLC

Phase 3

680

Nijmegen, Maastricht, 's-Hertogenbosch, Leeuwarden, Amersfoort, Groningen

2024-10-21

Active, closed

A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).

NCT06551324Metastatic Castrate Resistant Prostate Cancer (mCRPC)

DrugsMevrometostat·Xtandi·Taxotere·Enzalutamide

Pfizer

Phase 3

609

Nijmegen, Hilversum, Leeuwarden, Amersfoort

2024-10-21

Recruiting

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

NCT06662786Colorectal Neoplasms

DrugsLeucovorin calcium/Levoleucovorin·Amivantamab·Erbitux·Irinotecan

Janssen Research & Development, LLC

Phase 3

1,000

Amersfoort, Amsterdam, Nijmegen, Rotterdam, Tilburg, Utrecht

2024-10-18

Active, closed

A Phase 4, Randomised Vaccination Study in Healthy Adults to Investigate the Effects of Acellular Pertussis Vaccine on Colonisation With Bordetella Pertussis Using Controlled Human Infection

NCT06903221Pertussis Infection, Pertussis Vaccines

Dimitri Diavatopoulos

Phase 4

Nijmegen

2024-10-16

Recruiting

Study of ATX-01 in Participants With DM1

NCT06300307Myotonic Dystrophy 1

ARTHEx Biotech S.L.

Phase 1/2

Nijmegen

2024-10-15

Recruiting

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

NCT06562192Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, HR+/HER2- Ductal and Lobular Breast Cancer, Triple Negative Breast Cancer

Novartis Pharmaceuticals

Phase 1

162

Nijmegen, Utrecht

2024-10-15

Recruiting

LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis

NCT06632444Metabolic Dysfunction Associated Steatohepatitis (MASH), Liver Fibrosis

Boehringer Ingelheim

Phase 3

1,800

Amsterdam, Dordrecht, Nijmegen, Rotterdam, Schiedam, Tilburg

2024-10-14

Recruiting

Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations

NCT06581432Solid Tumours

DrugZongertinib

Boehringer Ingelheim

Phase 2

588

Amsterdam, Nijmegen

2024-10-11

Active, closed

Enhancement of Quality of Work And Life

NCT06573866Parkinson Disease, Hereditary Spastic Paraparesis, Cerebellar Ataxia, Mitochondrial Diseases

Radboud University Medical Center

Not applicable

124

Nijmegen

2024-10-08

Recruiting

Pain in Endometriosis And the Relation to Lifestyle

NCT06332560Endometriosis, Adenomyosis

Radboud University Medical Center

Not applicable

250

's-Hertogenbosch, Arnhem, Breda, Eindhoven, Nijmegen

2024-10-04

Recruiting

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

NCT05947955Acute Respiratory Distress Syndrome, Infections

BioAegis Therapeutics Inc.

Phase 2

600

's-Hertogenbosch, Apeldoorn, Ede, Enschede, Nijmegen

2024-10-03

Active, closed

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

NCT06525220Head and Neck Squamous Cell Carcinoma

DrugsPetosemtamab·Pembrolizumab

Genmab

Phase 3

699

Amsterdam, Nijmegen, Utrecht

2024-09-25

Recruiting

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

NCT06635148Geographic Atrophy, Macular Degeneration

Janssen Research & Development, LLC

Phase 2/3

274

Nijmegen, Rotterdam

2024-09-19

Active, closed

Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).

NCT06333951Thoracic Tumors, Non-small Cell Lung Cancer

DrugsAnvumetostat·Sotorasib·Pemetrexed·Paclitaxel

Amgen

Phase 1

Nijmegen

2024-09-17

Active, closed

Evaluation of the Effect of Lomitapide Treatment on Major Adverse Cardiovascular Events (MACE) in Patients With Homozygous Familial Hypercholesterolemia

NCT06832371Homozygous Familial Hypercholesterolemia (HoFH), Major Adverse Cardiovascular Events (MACE), Dyslipidemia

Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi)

Observational

Nijmegen, Rotterdam

2024-09-09

Recruiting

Ten Year Follow-up in FSHD: the FOCUS 3 Study

NCT06911190FSHD - Facioscapulohumeral Muscular Dystrophy

Radboud University Medical Center

Observational

200

Nijmegen

2024-09-01

Active, closed

Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)

NCT06564142Immunoglobulin A Nephropathy

DrugPovetacicept

Alpine Immune Sciences Inc, A Subsidiary of Vertex

Phase 3

605

Groningen, Nijmegen

2024-08-30

Recruiting

A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

NCT06452277Advanced Non-small Cell Lung Cancer, HER2 Mutation

DrugsSevabertinib·Pemetrexed·Cisplatin·Carboplatin

Bayer

Phase 3

444

Nijmegen, Amsterdam

2024-08-28

Recruiting

A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease

NCT06565195Parkinson's Disease

Prevail Therapeutics

Phase 1

124

Nijmegen, Groningen

2024-08-27

Recruiting

VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease

NCT06257706Moderately to Severely Active Crohn's Disease, Crohn Disease, Disease Crohn

DrugVedolizumab

Alimentiv Inc.

Phase 4

304

Nijmegen, Amsterdam, Rotterdam, Tilburg

2024-08-07

Active, closed

Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension

NCT06492291Hypercholesterolemia

DrugsEnlicitide·Enlicitide Decanoate

Merck Sharp & Dohme LLC

Phase 3

3,000

Nijmegen, Amsterdam, Hoorn, Utrecht

2024-08-05

Not yet open

FET-PET-Guided Management of Pseudoprogression in Glioblastoma

NCT06480721Glioblastoma, Radionecrosis of Brain

Veerle Ruijters

Not applicable

144

Amsterdam, Enschede, Groningen, Maastricht, Nijmegen, Rotterdam, The Hague, Utrecht

2024-08

Recruiting

Utility of Adjusting Chemotherapy Dose & Dosing Schedule With the SALVage Weekly Dose-dense Regimen in Patients With Poor Prognostic OVARian Cancers Based on the Tumor Unfavorable Primary Chemosensitivity and Incomplete Debulking Surgery

NCT06476184Ovarian Cancer

DrugsPaclitaxel·Carboplatin

ARCAGY/ GINECO GROUP

Phase 3

250

Amsterdam, Leiden, Nijmegen, Rotterdam

2024-07-30

Recruiting

The OPTIMISE Study

NCT05716945Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy, Intraocular Pressure

Maastricht University Medical Center

Phase 4

342

Apeldoorn, Nijmegen, Maastricht, Amsterdam, Deventer, Groningen, Leiden, Utrecht

2024-07-29

Recruiting

Nephroprotective Measures in Critically Ill Patients With Moderate/Severe Acute Kidney Injury

NCT06472999Acute Kidney Injury

Universität Münster

Observational

257

Nijmegen

2024-07-24

Active, closed

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

NCT06459180Cervical Cancer

DrugsTisotumab Vedotin·Vinorelbine·Topotecan·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

686

Nijmegen, Eindhoven, Amsterdam, Rotterdam, Groningen

2024-07-24

Recruiting

[18F]F-FAPI PET-CT to Identify Carcinoma of Unknown Primary Origin

NCT06644716Cancer of Unknown Primary

Erasmus Medical Center

Not applicable

Amsterdam, Groningen, Maastricht, Nijmegen, Rotterdam, Utrecht

2024-07-19

Recruiting

TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias

NCT07798674Hereditary Spastic Paraplegia, Spastic Ataxia

Heidelberg University

Observational

4,000

Nijmegen

2024-07-16

Recruiting

Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 or 2 Systemic Treatment Regimens

NCT06127407Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

DrugIvosidenib

Servier Bio-Innovation LLC

Phase 3

156

Groningen, Leiden, Nijmegen

2024-07-09

Recruiting

Detour: a Smartphone Game to Help Youth Quit Smoking

NCT06675526Smoking Cessation, Smoking Reduction, Adolescent Behavior, Social Behavior

Behavioural Science Institute

Not applicable

604

Nijmegen

2024-07-05

Recruiting

An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects

NCT04112992Limb Fracture, Bone Loss

AO Innovation Translation Center

Observational

600

Maastricht, Nijmegen

2024-07-03

Recruiting

Stereotactic Body Radiation Therapy After Chemotherapy for Unresectable Perihilar Cholangiocarcinoma

NCT06493734Klatskin Tumor

Erasmus Medical Center

Not applicable

Nijmegen, Maastricht, Amsterdam, Groningen, Rotterdam, Utrecht

2024-07-01

Active, closed

A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

NCT06496178Head and Neck Squamous Cell Carcinoma

DrugPetosemtamab

Genmab

Phase 3

621

Amsterdam, Nijmegen, Utrecht

2024-06-25

Recruiting

Diagnostic Performance of [18F]PSMA-1007 PET/CT Imaging in Patients With Newly-Diagnosed Prostate Cancer

NCT06122584Prostate Cancer

Drug18F-PSMA-1007

ABX advanced biochemical compounds GmbH

Phase 3

434

Nijmegen

2024-06-13

Recruiting

Improving Gastrointestinal Function In High-Risk Newborns By Stimulation Of The Enteric Nervous System

NCT06057415Feeding and Eating Disorders

Radboud University Medical Center

Not applicable

200

Nijmegen

2024-06-10

Recruiting

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

NCT06430801Crohn's Disease

DrugTulisokibart

Merck Sharp & Dohme LLC

Phase 3

1,200

Nijmegen, Tilburg, Uden, Amsterdam, Rotterdam, Groningen, Utrecht

2024-06-05

Recruiting

Hereditary Pheochromocytoma Assessment of Tumour Immunologies

NCT06444607Pheochromocytoma, Paraganglioma

Radboud University Medical Center

Observational

200

Nijmegen

2024-06-01

Active, closed

ELVN-002 With Trastuzumab +/- Chemotherapy in HER2+ Solid Tumors, Colorectal and Breast Cancer

NCT06328738HER2-positive Breast Cancer, HER2-positive Gastric Cancer, HER2 Positive Solid Tumors, HER2 Amplification

DrugsELVN-002·Eribulin·Leucovorin·Trastuzumab

Enliven Therapeutics

Phase 1

275

Nijmegen

2024-05-30

Active, closed

A Study Evaluating Anvumetostat in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)

NCT06360354Advanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers

DrugsAnvumetostat·Modified FOLFIRINOX·Cetuximab·Nab-paclitaxel

Amgen

Phase 1

120

Nijmegen

2024-05-29

Active, closed

A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy

NCT06393712Cerebral Amyloid Angiopathy

DrugsAln-App·Mivelsiran

Alnylam Pharmaceuticals

Phase 2

210

Amsterdam, Leiden, Nijmegen

2024-05-17

Active, closed

A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)

NCT06346067Advanced or Metastatic NRAS-mutant Melanoma

DrugsNaporafenib·Temodar·Dacarbazine·Trametinib

Erasca, Inc.

Phase 3

Amsterdam, Leiden, Nijmegen

2024-04-29

Recruiting

Delirium Treatment With Transcranial Electrical Stimulation

NCT06285721Delirium

A.J.C. Slooter

Not applicable

159

Nijmegen, The Hague

2024-04-24

Recruiting

A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)

NCT06330064Recurrent or Metastatic Solid Tumors

DrugIfinatamab Deruxtecan

Daiichi Sankyo

Phase 1/2

680

Amsterdam, Groningen, Nijmegen, Rotterdam, Utrecht

2024-04-10

Recruiting

Magnetic Resonance Imaging and Ultrasound Comparison With Load Evaluation

NCT06227182Muscular Dystrophy, Facioscapulohumeral

Radboud University Medical Center

Observational

100

Nijmegen

2024-04-10

Recruiting

The Natural History and Muscle Fatigability of Patients With Congenital Myopathies.

NCT06157268Central Core Disease, Multi-Minicore Disease, Nemaline Myopathy, Centronuclear Myopathy

Radboud University Medical Center

Observational

100

Nijmegen, Utrecht

2024-03-28

Active, closed

Speech Performance and Clinic Efficiency With Remote Care Compared With Standard of Care in Adults With a Cochlear Implant in the First 12 Months Post-activation

NCT05552118Hearing Loss

Cochlear

Not applicable

148

Maastricht, Nijmegen

2024-03-18

Recruiting

A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

NCT06072781Low Grade Serous Ovarian Cancer

DrugsAvutometinib·Defactinib·Pegylated liposomal doxorubicin·Anastrozole

Verastem, Inc.

Phase 3

270

Amsterdam, Nijmegen

2024-03-18

Recruiting

Drug Rediscovery for Rare Immune Mediated Inflammatory Diseases

NCT06285539Behcet's Disease, Idiopathic Inflammatory Myopathies, IgG4-related Disease

DrugFilgotinib

UMC Utrecht

Phase 2

Amsterdam, Heerlen, Nijmegen, Rotterdam, The Hague, Utrecht

2024-03-12

Recruiting

GUIDed Growth of the Proximal Femur to Prevent Further Hip MigrAtion in CErebral Palsy Patients

NCT06118736Cerebral Palsy, Hip Dislocation

Erasmus Medical Center

Not applicable

Amsterdam, Groningen, Maastricht, Nijmegen, Rotterdam

2024-03-06

Active, closed

First-in-human Dose Escalation and Expansion Study With the SIRPα-directed Monoclonal Antibody BYON4228

NCT05737628Lymphoma

DrugsBYON4228·Rituximab

Byondis B.V.

Phase 1

Amsterdam, Nijmegen

2024-03-04

Recruiting

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

NCT06172478Advanced Solid Tumor, Melanoma, Head and Neck Cancer, Gastric Cancer

DrugPatritumab deruxtecan

Daiichi Sankyo

Phase 2

740

Amsterdam, Groningen, Leiden, Maastricht, Nijmegen

2024-02-26

Active, closed

Study to Assess Speed of Onset and Durability of Effectiveness of Upadacitinib in Adult Participants With Moderate to Severe Crohn's Disease (CD) in Real World Clinical Practice.

NCT05930275Crohn's Disease

AbbVie

Observational

1,200

Nijmegen, Tilburg, Amsterdam

2024-02-19

Recruiting

Efficacy, Safety and Tolerability of Givinostat in Non-ambulant Patients With Duchenne Muscular Dystrophy

NCT05933057Duchenne Muscular Dystrophy

DrugHydroxyurea

Italfarmaco

Phase 3

138

Leiden, Nijmegen

2024-02-19

Active, closed

Stage II-IIIa Urothelial Cancer Randomizing Pre-operative Nivolumab With or Without Relatlimab

NCT06237920Urologic Neoplasms, Urogenital Neoplasms, Neoplasms by Site, Neoplasms

DrugsRelatlimab·Opdivo·Nivolumab

The Netherlands Cancer Institute

Phase 2

Arnhem, Nijmegen, Amsterdam, Hoofddorp, Zwolle, Leiden, Rotterdam, Utrecht

2024-02-19

Recruiting

Multicenter Registry of Patients With Subarachnoid Hemorrhage

NCT07482124Subarachnoid Hemorrhage, Spontaneous

UMC Utrecht

Observational

1,000

Nijmegen, Maastricht, Tilburg, Amsterdam, Zwolle, Groningen, Rotterdam, The Hague

2024-02-12

Recruiting

Effectiveness of Focal Therapy in Men With Prostate Cancer

NCT06223295Prostate Cancer, Prostate Neoplasm

Radboud University Medical Center

Not applicable

356

Nijmegen, Etten-Leur, Amsterdam, Zwolle, Nieuwegein

2024-02-01

Not yet open

Locally Advanced Pancreatic Cancer After Systemic Therapy: Ablative MR-guided Radiotherapy

NCT06272162Locally Advanced Pancreatic Adenocarcinoma

UMC Utrecht

Not applicable

150

Eindhoven, Amsterdam, Nijmegen, Utrecht

2024-02

Recruiting

Vegetarian Diet and Innate Immunity in Patients With Myocardial Infarction and in Healthy Volunteers (FRESH-MI Study)

NCT06209723Myocardial Infarction

Radboud University Medical Center

Not applicable

120

Nijmegen

2024-01-26

Recruiting

Use of Mechanical Left ventricuLar Unloading in Complex Higher-risk Indicated Procedures

NCT07380217High-risk PCI, Coronary Artery Disease Risk High

Amsterdam UMC, location VUmc

Not applicable

Amsterdam, Geleen, Groningen, Leiden, Maastricht, Nijmegen, The Hague, Utrecht

2024-01-25

Recruiting

Validation of Rapid On-site Diagnostics in Early Stage Lung Cancer Sampling With a Higher Harmonic Generation Microscope

NCT06007261Lung Cancer

Radboud University Medical Center

Observational

250

Nijmegen

2024-01-19

Recruiting

Pragmatic Optimized Rifampicin Trial

NCT06057519Tuberculosis, Pulmonary

Radboud University Medical Center

Phase 3

164

Nijmegen

2024-01-16

Recruiting

PEnile ReHABilitation After Nerve Sparing Robot-assisted Radical Prostatectomy for Prostate Cancer 2.0 (PEHAB-II)

NCT06875258Erectile Dysfunction Following Radical Prostatectomy

DrugSildenafil

The Netherlands Cancer Institute

Phase 4

198

Nijmegen, Amsterdam, Rotterdam

2024-01-15

Recruiting

Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands

NCT06193252Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Parkinsonian Disorders

Radboud University Medical Center

Not applicable

110

Nijmegen

2024-01-15

Recruiting

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

NCT06064877Metastatic Head-and-neck Squamous-cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma

DrugsErbitux·Cetuximab

AVEO Pharmaceuticals, Inc.

Phase 3

410

Amsterdam, Nijmegen

2024-01-11

Recruiting

Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

NCT06136624Prostate Cancer Metastatic

DrugsFludrocortisone acetate·Opevesostat·Zytiga·Hydrocortisone

Merck Sharp & Dohme LLC

Phase 3

1,310

Nijmegen, Sittard-Geleen, Venlo, Tilburg, Amsterdam, Hoofddorp, Leeuwarden, Schiedam

2023-12-31

Active, closed

REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors)

NCT05973773Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation

DrugZipalertinib

Taiho Oncology, Inc.

Phase 3

285

Nijmegen, Amsterdam

2023-12-18

Recruiting

The N-LVA Study: RCT Comparing LVA vs. Sham Surgery in Cancer-related Lymphedema

NCT06082349Lymphedema, Secondary, Lymphedema of Upper Limb, Lymphedema, Lower Limb, Lymphedema Arm

Maastricht University Medical Center

Not applicable

110

Nijmegen, Maastricht, Rotterdam

2023-12-18

Recruiting

Personalized Elective Neck Irradiation Guided by Sentinel Lymph Node Biopsy in Larynx and Pharynx Cancer. The PRIMO Study.

NCT05333523Laryngeal Squamous Cell Carcinoma, Hypopharynx Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma

Radboud University Medical Center

Phase 3

242

Amsterdam, Arnhem, Enschede, Groningen, Leiden, Maastricht, Nijmegen, Rotterdam

2023-12-06

Active, closed

Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

NCT06132958Endometrial Cancer

DrugsAbraxane·Adriamycin·Sacituzumab tirumotecan·Taxol

Merck Sharp & Dohme LLC

Phase 3

710

Nijmegen, Amsterdam, Leiden

2023-12-06

Recruiting

The Effect of Compensation Strategies on Gait Impairment in Parkinson's Disease

NCT06142448Parkinson Disease

Radboud University Medical Center

Not applicable

384

Nijmegen

2023-12-01

Recruiting

Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.

NCT05948943Lymphatic Malformations

DrugAlpelisib

Novartis Pharmaceuticals

Phase 2/3

232

Rotterdam, Nijmegen

2023-11-24

Active, closed

Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents

NCT06120491Metastatic Castration-Sensitive Prostate Cancer

DrugsSaruparib·Zytiga·Xtandi·Abiraterone acetate

AstraZeneca

Phase 3

1,898

Amsterdam, Hilversum, Nijmegen

2023-11-21

Recruiting

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

NCT05920356Non-Small Cell Lung Cancer (NSCLC)

DrugsLumakras·Sotorasib·Pembrolizumab

Amgen

Phase 3

750

Amersfoort, Groningen, Harderwijk, Maastricht, Nijmegen, Tilburg, Zwolle

2023-11-16

Recruiting

Dutch-Depression Outcome Trial Comparing 5 Day Multi Daily Neuronavigated Theta Burst Sessions With 6 Weeks rTMS

NCT05900271Treatment Resistant Depression

Amsterdam UMC, location VUmc

Not applicable

108

Nijmegen, Amsterdam, Amsterdam-Zuidoost, Maastricht

2023-11-15

Recruiting

Neural Control of Breathing in Parkinson's Disease

NCT06074614Parkinson Disease

Radboud University Medical Center

Observational

Nijmegen

2023-10-30

Recruiting

Early Longitudinal Imaging in the Parkinson's Progressive Marker Initiative (PPMI) Using (18F)AV-133 (PPMI AV-133 Prodromal Imaging)

NCT07265596Prodromal Parkinsons Disease

Michael J. Fox Foundation for Parkinson's Research

Phase 2

100

Nijmegen

2023-10-30

Active, closed

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

NCT06052059Ulcerative Colitis

DrugTulisokibart

Merck Sharp & Dohme LLC

Phase 3

1,109

Nijmegen, Tilburg, Uden, Amsterdam, Deventer, Rotterdam, Utrecht

2023-10-25

Active, closed

Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure

NCT05598333Congestive Heart Failure

AskBio Inc

Phase 2

150

Amsterdam, Nijmegen, Rotterdam, Utrecht

2023-10-20

Active, closed

A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC

NCT05968326Adenocarcinoma, Pancreatic Ductal

DrugsAutogene cevumeran·MFOLFIRINOX·Tecentriq·Atezolizumab

Genentech, Inc.

Phase 2

260

Amsterdam, Nijmegen, Rotterdam

2023-10-18

Active, closed

Oral N-acetylcysteine for Retinitis Pigmentosa

NCT05537220Retinitis Pigmentosa

DrugN-Acetylcysteine

Johns Hopkins University

Phase 3

485

Nijmegen, Amsterdam

2023-10-11

Active, closed

A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma

NCT05257083Multiple Myeloma

DrugsCilta-cel·Bortezomib·Daratumumab·Lenalidomide

Stichting European Myeloma Network

Phase 3

759

Amsterdam, Groningen, Nijmegen, Rotterdam, Utrecht

2023-10-10

Active, closed

Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes

NCT06008756Arteriosclerosis, Hypercholesterolaemia

DrugEnlicitide Decanoate

Merck Sharp & Dohme LLC

Phase 3

14,550

Emmen, Hoogeveen, Apeldoorn, Doetinchem, Ede, Harderwijk, Nijmegen, Tiel

2023-10-09

Recruiting

An 18-month Prospective Natural History Study to Gain Insight Into FSHD2 Pathophysiology and Disease Progression

NCT06079567Facioscapulohumeral Muscular Dystrophy Type 2

Centre Hospitalier Universitaire de Nice

Not applicable

Nijmegen

2023-10-03

Active, closed

A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies

NCT05957367GIST

DrugRipretinib

Deciphera Pharmaceuticals, LLC

Phase 1/2

Amsterdam, Nijmegen

2023-09-28

Active, closed

Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2

NCT05911295Urothelial Carcinoma

DrugsDisitamab Vedotin·Keytruda·Gemcitabine·Cisplatin

Seagen, a wholly owned subsidiary of Pfizer

Phase 3

412

Amsterdam, Arnhem, Breda, Nijmegen, The Hague

2023-09-22

Recruiting

A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

NCT05730036Relapsed Refractory Multiple Myeloma (RRMM)

DrugsElotuzumab·Linvoseltamab·Pomalidomide·Dexamethasone

Regeneron Pharmaceuticals

Phase 3

410

Nijmegen, Dordrecht

2023-09-18

Recruiting

Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

NCT05803941Prostate Cancer

DrugLu-PSMA

Novartis Pharmaceuticals

Phase 4

700

Nijmegen, Maastricht, Delft

2023-08-14

Recruiting

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

NCT05855200Colonic Neoplasms, Neoplasms, Colon

DrugsCapeox·Dostarlimab·Folfox

GlaxoSmithKline

Phase 3

892

Breda, Maastricht, Nijmegen, Utrecht

2023-08-01

Recruiting

Clinical and Cost-effectiveness of Group Schema Therapy for Complex Eating Disorders: the GST-EAT Study

NCT05812950Anorexia Nervosa, Atypical Anorexia Nervosa (Other Specified Eating Disorder), Bulimia Nervosa, Atypical Bulimia Nervosa (Other Specified Eating Disorder)

Maastricht University

Not applicable

230

Breda, Groningen, Leeuwarden, Nijmegen, Tilburg, Utrecht, Warnsveld

2023-07-24

Recruiting

ClassIntra® for Better Outcomes in Surgery - CIBOSurg

NCT05818332Perioperative Patient Safety

University Hospital, Basel, Switzerland

Observational

1,800

Nijmegen

2023-07-17

Active, closed

Zenith Thoracic Alpha (ZTA) Post-Market Data Collection

NCT06094127Thoracic Aortic Aneurysm, Penetrating Aortic Ulcer

Cook Research Incorporated

Observational

300

Maastricht, Nijmegen

2023-07-06

Active, closed

Safety of Ticagrelor Monotherapy After Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction and the Effect on Intramyocardial Haemorrhage

NCT05986968ST Elevation Myocardial Infarction

DrugsTicagrelor·Aspirin

Radboud University Medical Center

Not applicable

200

Alkmaar, Amsterdam, Arnhem, Enschede, Nijmegen

2023-07-06

Recruiting

A Prospective, Multicenter, Single-arm MAC-PD Cohort: a NTM-NET and ESGMYC Collaborative Study

NCT05906316Mycobacterium Avium Complex Pulmonary Disease

Radboud University Medical Center

Observational

100

Nijmegen

2023-07-01

Recruiting

Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study

NCT06016946Friedreich Ataxia

Friedreich's Ataxia Research Alliance

Observational

3,000

Nijmegen

2023-06-28

Active, closed

Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

NCT05701358Acute Myocardial Infarction, Coronary Artery Disease

Population Health Research Institute

Not applicable

5,100

Amsterdam, Dordrecht, Heerlen, Nijmegen

2023-06-22

Recruiting

POS-ARI-ER Observational Study of Acute Respiratory Infections

NCT05814237Acute Respiratory Infection, Acute Respiratory Tract Infection

European Clinical Research Alliance for Infectious Diseases (ECRAID)

Observational

11,750

Alkmaar, Amsterdam, Nijmegen

2023-06-20

Recruiting

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

NCT05789082Non-Small Cell Lung Cancer

DrugsDivarasib·Pemetrexed·Cisplatin·Carboplatin

Hoffmann-La Roche

Phase 1/2

320

Amsterdam, Nijmegen

2023-06-20

Recruiting

Dutch Registry of Pediatric Cardiac Arrest

NCT06938009Cardiac Arrest (CA), Pediatric ALL

Matthijs de Hoog

Observational

500

Nijmegen, Maastricht, Amsterdam, Groningen, Leiden, Rotterdam, Utrecht

2023-06-14

Active, closed

Prospective Observational Study of Effectiveness and Safety of Filgotinib in Participants With Ulcerative Colitis (UC)

NCT05817942Ulcerative Colitis

DrugFilgotinib

Alfasigma S.p.A.

Observational

509

Amsterdam, Geleen, Nijmegen, Rotterdam, Tilburg, Utrecht

2023-06-12

Active, closed

An Observational Study to Assess Change in Disease Activity and Adverse Events In Adult Participants With Moderate to Severe Active Crohn's Disease (CD)

NCT05841537Crohn's Disease

AbbVie

Observational

1,019

Nijmegen, Heerlen, Tilburg

2023-06-09

By invitation

Long-term Extension Study to Assess Adverse Events of Oral Atogepant Tablets in Pediatric Participants (6 to 17 Years of Age) With Migraine

NCT05707949Migraine Prophylaxis

DrugAtogepant

AbbVie

Phase 3

650

Nijmegen, Terneuzen, The Hague

2023-06-05

Active, closed

An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis

NCT05809531C3G, IC-MPGN, C3 Glomerulopathy, C3 Glomerulonephritis

DrugPegcetacoplan

Apellis Pharmaceuticals, Inc.

Phase 3

100

Amsterdam, Groningen de Brug, Nijmegen

2023-05-29

Recruiting

Scandinavian Trial of Uncomplicated Aortic Dissection Therapy

NCT05215587Aortic Dissection

University of Aarhus

Not applicable

554

Amsterdam, Groningen, Leiden, Maastricht, Nijmegen, Rotterdam, Utrecht

2023-05-24

Recruiting

Cerclage for the Reduction of Extreme Preterm Birth in Twin Pregnancies With a Short Cervix or Dilatation

NCT05968794Preterm Birth

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Not applicable

238

Amsterdam, Groningen, Leiden, Maastricht, Nijmegen, Rotterdam, Utrecht, Veldhoven

2023-05-15

Recruiting

Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

NCT05589714Inherited Retinal Degeneration, Retinitis Pigmentosa

Jaeb Center for Health Research

Observational

1,500

Nijmegen

2023-05-11

Active, closed

Percutaneous Holmium Injection in Pancreatic Cancer

NCT05880472Pancreas Cancer

Radboud University Medical Center

Not applicable

Nijmegen

2023-05-01

Recruiting

Evalutation of a Hybrid Care Pathway With Remote MONitoring for Heart Failure

NCT07680634Heart Failure

St. Antonius Hospital

Observational

6,000

Amsterdam, Eindhoven, Enschede, Groningen, Nieuwegein, Nijmegen, Rotterdam

2023-05-01

Recruiting

A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

NCT05711394Episodic Migraine

DrugAtogepant

AbbVie

Phase 3

450

Nijmegen, The Hague, Terneuzen

2023-05-01

Active, closed

The Effects of Mindfulness-based Cognitive Therapy in People With Parkinson's Disease

NCT05779137Parkinson's Disease

Radboud University Medical Center

Not applicable

174

Nijmegen

2023-04-17

Recruiting

Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection

NCT06172010Prosthetic-joint Infection, Infection Hip, Infection; Knee, Joint

DrugClindamycin

Leiden University Medical Center

Phase 4

316

Leiden, Amsterdam, Groningen, Hoofddorp, Leeuwarden, Leiderdorp, Nijmegen, Rotterdam

2023-04-01

Active, closed

A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)

NCT05714202Bladder Cancer

DrugsTAR-200·Cetrelimab

Janssen Research & Development, LLC

Phase 3

1,135

Hoofddorp, Nijmegen

2023-03-23

Recruiting

NEOadjuvant Dendritic Cell Vaccination for Ovarian Cancer

NCT05773859Epithelial Ovarian Cancer, Ovarian Carcinoma

Radboud University Medical Center

Phase 1/2

Nijmegen

2023-03-17

Active, closed

A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.

NCT05739383Primary Prevention of Atherosclerotic Cardiovascular Disease

DrugInclisiran

Novartis Pharmaceuticals

Phase 3

14,012

Arnhem, Doetinchem, Nijmegen, 's-Hertogenbosch, Tilburg, Amsterdam, Beverwijk, Deventer

2023-03-09

Active, closed

REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

NCT05669755Cardiovascular Disease

DrugsCagrilintide·Semaglutide

Novo Nordisk A/S

Phase 3

7,101

Apeldoorn, Eindhoven, Gouda, Groningen, Leeuwarden, Nijmegen, Rotterdam, Sneek

2023-03-01

Recruiting

The (Cost-)Effectiveness of Surgical Excision of Colorectal Endometriosis Compared to ART Treatment Trajectory

NCT05677269Endometriosis, Rectum, Endometriosis of Colon, Subfertility, Female

Leiden University Medical Center

Observational

339

Eindhoven, Enschede, Groningen, Leiden, Maastricht, Nijmegen, Rotterdam, The Hague

2023-02-17

Recruiting

A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD

NCT05822908Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 3, Huntington Disease

Vico Therapeutics B. V.

Phase 1/2

Leiden, Nijmegen

2023-02-14

Active, closed

A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

NCT05578976Diffuse Large B-Cell Lymphoma

DrugsEpcoritamab·Vincristine·Doxorubicin·Prednisone

Genmab

Phase 3

900

Almere Stad, Apeldoorn, Nijmegen, Maastricht, Breda, Eindhoven, Tilburg, Alkmaar

2023-02-08

Recruiting

Observational Dutch Young Symptomatic StrokE studY - nEXT

NCT05853796Ischemic Stroke, Stroke in the Young, Cardiovascular Diseases, Cerebrovascular Disorders

Radboud University Medical Center

Observational

280

Nijmegen, Eindhoven, Enschede, Zwolle, The Hague, Leeuwarden

2023-02-06

Recruiting

Prediction Models for Complications After CRT in Esophageal Cancer

NCT06366828The Aim of This Project is to Develop and Validate NTCP-models for Complications After nCRT (and Surgical Resection)

University Medical Center Groningen

Observational

2,000

Nijmegen, Maastricht, Amsterdam, Rotterdam, Delft, Groningen, Heerlen, Utrecht

2023-02-01

Active, closed

ABTECT - Maintenance

NCT05535946Ulcerative Colitis

DrugObefazimod

Abivax S.A.

Phase 3

1,116

Amsterdam, Geleen, Nijmegen, Rotterdam, Tilburg, Uden, Utrecht

2023-01-16

Recruiting

The COllaborative Neonatal Network for the First CPAM Trial

NCT05701514Congenital Pulmonary Airway Malformation

Erasmus Medical Center

Not applicable

176

Nijmegen, Rotterdam

2023-01-01

Active, closed

Colchicine and Inflammation in Aortic Stenosis

NCT05162742Aortic Valve Disease, Aortic Valve Stenosis, Aortic Valve Calcification, Inflammation

DrugColchicine

Radboud University Medical Center

Phase 3

150

Nijmegen

2022-12-22

Recruiting

Study to Determine the Safety and Pharmacokinetics of DO-2 in Patients With Advanced or Refractory Solid Tumours

NCT05752552Adult Solid Tumor, Advanced Solid Tumor, Refractory Tumor, Non-small Cell Lung Cancer

DeuterOncology

Phase 1

Nijmegen, Rotterdam

2022-12-20

Recruiting

Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease

NCT05650229Primary Mitochondrial Disease

DrugNapazimone

Pharming Technologies B.V.

Phase 2

180

Nijmegen

2022-12-13

Active, closed

CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)

NCT05681351Severe Hypertriglyceridemia

DrugOlezarsen

Ionis Pharmaceuticals, Inc.

Phase 3

885

Amsterdam, Apeldoorn, Arnhem, Dirksland, Ede, Hoogeveen, Nijmegen, Rotterdam

2022-12-13

Recruiting

Impact of Peri-operative tEstosterone Levels on oNcological and Functional Outcomes in RadiCal prostatEctomy

NCT04833426Prostatic Neoplasms, Hypogonadism, Testosterone Deficiency

DrugTestosterone

Canisius-Wilhelmina Hospital

Phase 3

140

Amsterdam, Arnhem, Eindhoven, Emmen, Heerlen, Nieuwegein, Nijmegen, Veldhoven

2022-12-12

Recruiting

Prevention of Opioid-induced Constipation in Patients With Advanced Cancer

NCT05216328Constipation, Opioid-Induced

Amsterdam UMC, location VUmc

Phase 4

258

Almere Stad, Arnhem, Nijmegen, 's-Hertogenbosch, Amsterdam, Hoofddorp, Groningen, Gouda

2022-12-02

Recruiting

Chemotherapy and Sequential Immunotherapy for Locally Advanced Urothelial Cancer

NCT05600127Urothelial Carcinoma

DrugAvelumab

Erasmus Medical Center

Phase 2

Nijmegen, 's-Hertogenbosch, Breda, Rotterdam

2022-12-01

Not yet open

Addition of a Focal Boost in External Beam Radiotherapy for Locally Advanced Prostate Cancer by Online Adaptive MR-guided Radiotherapy

NCT05373316Prostate Cancer, Prostate Neoplasm

Radboud University Medical Center

Phase 2

Nijmegen, Amsterdam

2022-12-01

Active, closed

Dose-finding Study of SAR443122 in Adult Participants With Ulcerative Colitis

NCT05588843Colitis Ulcerative

Sanofi

Phase 2

187

Amsterdam, Nijmegen

2022-11-25

Active, closed

Study to Evaluate Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) Long-term Safety and Efficacy in Subjects Without F508del

NCT05331183Cystic Fibrosis

DrugsELX/TEZ/IVA·Ivacaftor·Elexacaftor/Tezacaftor/Ivacaftor

Vertex Pharmaceuticals Incorporated

Phase 3

297

Amsterdam, Nijmegen, Rotterdam, The Hague, Utrecht

2022-11-23

Active, closed

Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis

NCT05583227Eosinophilic Esophagitis

DrugTezepelumab

AstraZeneca

Phase 3

368

Amsterdam, Nijmegen, Rotterdam

2022-11-10

Recruiting

Phase II Randomised Controlled Trial of Patient-specific Adaptive vs. Continuous Abiraterone or eNZalutamide in mCRPC

NCT05393791Prostatic Neoplasms, Castration-Resistant

DrugsZytiga·Xtandi·Abiraterone acetate·Enzalutamide

Leiden University Medical Center

Phase 2

168

Nijmegen, Hoofddorp, Zwolle, Gouda, Leiden, Amersfoort, Groningen

2022-11-10

Active, closed

A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy

NCT05444257Cystic Fibrosis

DrugVNZ/TEZ/D-IVA

Vertex Pharmaceuticals Incorporated

Phase 3

822

Amsterdam, Nijmegen, Rotterdam, The Hague, Utrecht

2022-11-08

Recruiting

Repeated GON Injections in CCH

NCT05324748Cluster Headache

DrugMethylprednisolone

Leiden University Medical Center

Phase 3

Leiden, Nijmegen

2022-11-07

Recruiting

Dutch Intracerebral Hemorrhage Surgery Trial

NCT05460793Intracerebral Hemorrhage, Minimally Invasive Surgical Procedures, Endoscopic Surgical Procedures

Radboud University Medical Center

Not applicable

600

Amsterdam, Enschede, Groningen, Leiden, Maastricht, Nijmegen, Rotterdam, The Hague

2022-11-03

Active, closed

He-move-philia, Lifestyle Intervention for Patients With Hemophilia

NCT05608863Hemophilia

Radboud University Medical Center

Not applicable

Nijmegen

2022-11-02

Recruiting

Gag Therapy for Recurrent Urinary Tract Infection Assessing Comparability to International Nitrofurantoin Gold Standard Study

NCT05652374Recurrent Urinary Tract Infection

DrugNitrofurantoin

Radboud University Medical Center

Phase 4

100

Nijmegen, Arnhem

2022-10-20

Active, closed

Comparison of Point-of-care Produced CAR T-cell With Commercial CAR T-cells in Patients With R/R LBCL

NCT05641428NHL, DLBCL - Diffuse Large B Cell Lymphoma

DrugAxi-cel

University Medical Center Groningen

Phase 2

340

Amsterdam, Groningen, Leiden, Maastricht, Nijmegen, Rotterdam, Utrecht

2022-10-18

Recruiting

PROMOTE Study: Prediction of Response Of HorMOnal Treatment in Advanced and Recurrent Endometrial Cancer

NCT03621904Endometrial Cancer Stage III, Endometrial Cancer Stage IV, Endometrial Cancer Recurrent

DrugsProgesterone·Tamoxifen

Radboud University Medical Center

Observational

150

Nijmegen

2022-10-15

Recruiting

Phase II Dutasteride in Combination With CAB vs CAB in SDC

NCT05513365Salivary Duct Carcinoma

DrugsDutasteride·Zoladex·Bicalutamide·Goserelin

Radboud University Medical Center

Phase 2

Nijmegen

2022-09-27

Active, closed

A Study of Guselkumab in Participants With Fistulizing, Perianal Crohn's Disease

NCT05347095Fistulizing Crohns Disease, Perianal Crohns Disease

DrugGuselkumab

Janssen-Cilag Ltd.

Phase 3

288

Amsterdam, Nijmegen, Rotterdam, Utrecht

2022-09-27

Recruiting

INSIGHTFUL-FFR Clinical Trial

NCT05437900Coronary Artery Disease, Acute Coronary Syndrome

CoreAalst BV

Phase 4

2,500

Amsterdam, Eindhoven, Nijmegen

2022-09-22

Active, closed

The Euro-CRAFT Registry

NCT05805462Coronary Microvascular Disease

CoreAalst BV

Observational

671

Eindhoven, Nijmegen, Rotterdam

2022-09-22

Active, closed

Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma

NCT05409066Follicular Lymphoma (FL)

DrugsEpcoritamab·Lenalidomide·Rituximab

Genmab

Phase 3

549

Nijmegen, Breda, Amsterdam, Hoorn, Enschede, Dordrecht, Leiden, Rotterdam

2022-09-20

Active, closed

Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-101 in Participants With Myotonic Dystrophy Type 1

NCT05481879Myotonic Dystrophy Type 1 (DM1)

DrugZeleciment basivarsen

Dyne Therapeutics

Phase 1/2

127

Nijmegen

2022-09-05

Recruiting

Single-dose Preoperative Partial Breast Irradiation in Low-risk Breast Cancer Patients

NCT05350722Breast Cancer

Amsterdam UMC, location VUmc

Not applicable

100

Almere Stad, Amstelveen, Amsterdam, Nijmegen, Zaandam

2022-08-24

Recruiting

Comparison Of Reduced DAPT Followed by P2Y12 Inhibitor Monotherapy With Prasugrel vs stAndard Regimen in STEMI Patients

NCT05491200ST Elevated Myocardial Infarction, Dual Antiplatelet Therapy

Research Maatschap Cardiologen Rotterdam Zuid

Phase 4

1,656

Breda, Dordrecht, Eindhoven, Nijmegen, Rotterdam, The Hague

2022-07-22

Recruiting

Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection

NCT05413850Prostate Cancer, Metastatic Castration-resistant Prostate Cancer, mCRPC, Urogenital Neoplasms

Blue Earth Therapeutics Ltd

Phase 1/2

Nijmegen, Amersfoort

2022-07-20

Recruiting

The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

NCT05203172Solid Tumors

DrugsVemurafenib·Encorafenib·Binimetinib·Zirabev

Pfizer

Phase 4

210

Nijmegen, Amsterdam, Zwolle

2022-07-05

Recruiting

The Effect of a Combined Personalized Nutritional Intervention and a Personalized Graded Activity Functional Training Program on Physical Performance in Hospitalized Older Patients, Compared to Usual Care

NCT05413616Old Age; Atrophy

Radboud University Medical Center

Not applicable

136

Nijmegen

2022-07-04

Active, closed

A Trial to Assess the Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With PLD

NCT05281328Polycystic Liver Disease

DrugCAM2029

Camurus AB

Phase 2/3

Nijmegen

2022-06-28

Active, closed

TREAT Study - Improving the Interpretation of Troponin Concentrations Following Exercise and Their Clinical Significance

NCT06295081Coronary Artery Disease

Radboud University Medical Center

Observational

1,015

Nijmegen

2022-06-15

Active, closed

Non-interventional Study on Osilodrostat in Patients With Endogenous Cushing's Syndrome

NCT05382156Endogenous Cushing's Syndrome

DrugOsilodrostat

RECORDATI GROUP

Observational

206

Nijmegen, Rotterdam

2022-06-13

Recruiting

A GnRH Agonist IN Pre-menopausal Women STudy to Treat Severe Polycystic Liver Disease

NCT05478083Polycystic Liver Disease, Autosomal Dominant Polycystic Kidney

DrugLeuprorelin

University Medical Center Groningen

Phase 2

Nijmegen, Groningen

2022-06-01

Recruiting

Predicting Response In Cervical Intraepithelial Neoplasia to Topical Imiquimod Treatment

NCT05405270Cervical High Grade Squamous Intraepithelial Lesion, Cervical Intraepithelial Neoplasia Grade 2/3, CIN 2/3, Cervical Intraepithelial Neoplasia

DrugImiquimod

Catharina Ziekenhuis Eindhoven

Observational

410

Breda, Dordrecht, Eindhoven, Hilversum, Leeuwarden, Leiden, Maastricht, Nijmegen

2022-06-01

Recruiting

A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia

NCT05304377Chronic Myeloid Leukemia, Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Cml

DrugELVN-001

Enliven Therapeutics

Phase 1

250

Nijmegen

2022-05-22

Recruiting

Hypertonic Saline Inhalation for Mycobacterium Avium Complex Pulmonary Disease

NCT05192057Nontuberculous Mycobacterial Lung Disease, Mycobacterium Avium Complex

Radboud University Medical Center

Phase 4

Nijmegen

2022-05-20

Active, closed

Long Term Effects of BCG Vaccination on Infectious and Immune Mediated Diseases

NCT05387655BCG Vaccination Reaction, Infections, Inflammation, COVID-19

Radboud University Medical Center

Observational

4,292

Nijmegen

2022-05-20

Recruiting

Open-label Study of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis (sHLH)

NCT05416307Secondary Hemophagocytic Lymphohistiocytosis (sHLH)

DrugELA026

Electra Therapeutics Inc.

Phase 2/3

156

Amsterdam, Nijmegen, Rotterdam, Utrecht

2022-05-19

Active, closed

Cross-cultural Adaptation and Validation of the Localised Scleroderma Quality of Life Instrument (LoSQI) in Juvenile Localised Scleroderma (JLS)

NCT07908108Scleroderma

Istituto Giannina Gaslini

Observational

272

Amsterdam, Nijmegen

2022-05-18

Recruiting

TMS for Exposure Therapy Resistant OCD

NCT053319371 Hz Real rTMS to the Pre-SMA, 1 Hz Sham rTMS to the Pre-SMA

Amsterdam UMC, location VUmc

Phase 3

250

Amsterdam, Eindhoven, Groningen, Maastricht, Nijmegen

2022-05-16

Active, closed

Adjuvant Encorafenib and Binimetinib in High-risk Stage II Melanoma With a BRAF Mutation.

NCT05270044Melanoma

Pierre Fabre Medicament

Phase 3

815

Amsterdam, Groningen, Leiden, Maastricht, Nijmegen, Rotterdam, Utrecht, Zwolle

2022-05-02

Recruiting

ADT +/- Darolutamide in de Novo Metastatic Prostate Cancer Patients With Vulnerable Functional Ability (PEACE6-Vulnerable)

NCT04916613Prostate Cancer Metastatic

DrugDarolutamide

UNICANCER

Phase 3

300

Dordrecht, Nijmegen

2022-04-19

Recruiting

Brentuximab Vedotin in Early Stage Hodgkin Lymphoma

NCT04685616Hodgkin Lymphoma

DrugsVinblastine·Filgrastim·Pegfilgrastim·Bleomycin

University College, London

Phase 3

1,042

Amsterdam, Delft, Groningen, Nijmegen, The Hague

2022-04-14

Recruiting

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

NCT05208047Advanced Gastrointestinal Stromal Tumors, Metastatic Cancer

DrugsBezuclastinib·Sunitinib·Midazolam

Cogent Biosciences, Inc.

Phase 3

482

Amsterdam, Groningen, Nijmegen, Rotterdam

2022-04-14

Recruiting

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

NCT05131022Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Diffuse Large B Cell Lymphoma (DLBCL), Follicular Lymphoma (FL)

DrugBexobrutideg

Nurix Therapeutics, Inc.

Phase 1

572

Groningen, Nijmegen, Rotterdam, Utrecht

2022-04-13

Active, closed

Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer

NCT05316155Non-Muscle Invasive Bladder Neoplasms

DrugErdafitinib

Janssen Research & Development, LLC

Phase 1/2

235

Nijmegen, Utrecht

2022-04-11

Active, closed

Effectiveness of MR-guided LITT Therapy in Irresectable Glioblastoma (EMITT)

NCT05318612Primary Glioblastoma

Radboud University Medical Center

Phase 3

238

Amsterdam, Groningen, Maastricht, Nijmegen, Rotterdam, Tilburg, Utrecht

2022-04-08

Active, closed

Progression Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound Flow Imaging

NCT05270005Carotid Artery Stenosis

Rijnstate Hospital

Observational

Arnhem, Nijmegen

2022-04-07

By invitation

Trial of Sibeprenlimab in the Treatment of Immunoglobulin A Nephropathy (IgAN)

NCT05248659Immunoglobulin A Nephropathy

DrugSibeprenlimab

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 2/3

600

Nijmegen

2022-04-05

Active, closed

Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)

NCT05270668Diffuse Cutaneous Systemic Sclerosis, Interstitial Lung Disease

DrugTulisokibart

Prometheus Biosciences, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 2

154

Nijmegen

2022-03-29

Recruiting

Comparison of Standard Dose Alectinib to Alectinib in Adjusted Dose Based on Alectinib Bloodlevels

NCT05525338Drug Monitoring, Carcinoma, Non-Small-Cell Lung, Lung Cancer, Anaplastic Lymphoma Kinase Gene Mutation

DrugAlectinib

University Medical Center Groningen

Phase 4

196

Nijmegen, Maastricht, Amsterdam, Leiden, Rotterdam, Groningen

2022-03-23

Active, closed

Aerobe Cycling Training in Women With Unexplained Recurrent Pregnancy Loss

NCT06007560Recurrent Pregnancy Loss

Radboud University Medical Center

Not applicable

Maastricht, Nijmegen

2022-03-21

Active, closed

A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

NCT05239728Carcinoma, Renal Cell

DrugsBelzutifan·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

1,800

Arnhem, Nijmegen, Maastricht, Breda, Eindhoven, Amsterdam, Hilversum, Hoofddorp

2022-03-15

Active, closed

Trial of Sibeprenlimab in the Treatment of A Nephropathy (IgAN)

NCT05248646Immunoglobulin A Nephropathy

DrugSibeprenlimab

Otsuka Pharmaceutical Development & Commercialization, Inc.

Phase 3

530

Nijmegen, Maastricht, Gouda, Amsterdam

2022-03-15

Active, closed

Fragility Fractures of the Pelvis (FFP)

NCT04182776Pelvic Fracture

AO Innovation Translation Center

Observational

420

Groningen, Nijmegen

2022-03-01

Recruiting

An European Multi-centre Cohort Study for Unravelling Pharmacokinetic and Genetic Factors Underlying Post-ERCP Pancreatitis

NCT05267379Post-ERCP Acute Pancreatitis

Radboud University Medical Center

Observational

700

Nijmegen

2022-03-01

Active, closed

Dutch Multidomain Lifestyle Intervention in Older Adults at Risk of Cognitive Decline

NCT05256199Cognitive Decline, Life Style, Risk Reduction

Alzheimercentrum Amsterdam

Not applicable

1,210

Amsterdam, Groningen, Maastricht, Nijmegen, Wageningen

2022-02-24

Recruiting

Staphylococcus Aureus Network Adaptive Platform Trial

NCT05137119Staphylococcus Aureus Bacteremia

DrugsDaptomycin·Benzylpenicillin·Clindamycin·Cefazolin

University of Melbourne

Phase 4

8,000

's-Hertogenbosch, Arnhem, Emmen, Groningen, Maastricht, Nieuwegein, Nijmegen, Rotterdam

2022-02-16

Active, closed

Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)

NCT05173987Endometrial Neoplasms

DrugsTaxotere·Platinol-AQ·Paraplatin·Taxol

Merck Sharp & Dohme LLC

Phase 3

280

Nijmegen, Maastricht, Eindhoven, Amsterdam, Leiden, Rotterdam, Groningen, Utrecht

2022-02-03

Active, closed

MONITOR-IC Post ICU Care Study

NCT05066984Post ICU Syndrome

Radboud University Medical Center

Not applicable

2,250

Nijmegen

2022-02-01

Active, closed

Prospective Assessment of Cost-effectiveness and Side-effects of Depressive Patients Treated With ECT or TCA

NCT05306184Depressive Disorder, Major

Radboud University Medical Center

Observational

220

Amsterdam, Nijmegen

2022-01-01

Active, closed

A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)

NCT04819100Carcinoma, Non-Small-Cell Lung

DrugSelpercatinib

Eli Lilly and Company

Phase 3

152

Harderwijk, Nijmegen

2021-12-20

By invitation

Long-Term Follow-Up Study After Gene-Modified Cell Treatment in Kite Studies

NCT05041309Solid and Hematological Malignancies, Autoimmune Diseases

DrugsKITE-197·SPRX002·KITE-753·Tecartus

Kite, A Gilead Company

Observational

1,500

Amsterdam, Groningen, Nijmegen, Rotterdam, Utrecht

2021-12-15

Active, closed

Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).

NCT05116189Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms

DrugsZirabev·Taxotere·Avastin·Keytruda

Merck Sharp & Dohme LLC

Phase 3

643

Nijmegen, Leiden, Rotterdam, Utrecht

2021-12-13

Active, closed

EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke

NCT05029414Acute Ischemic Stroke

University Hospital, Basel, Switzerland

Not applicable

543

Amsterdam, Arnhem, Groningen, Leiden, Maastricht, Nijmegen, Rotterdam, The Hague

2021-12-09

Recruiting

Optical Coherence Tomography: Prognostic Value and Artificial Intelligence

NCT07293858Coronary Arterial Disease

Radboud University Medical Center

Observational

1,000

Nijmegen

2021-11-26

Active, closed

Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease

NCT05030428Atherosclerotic Cardiovascular Disease

DrugInclisiran sodium

Novartis Pharmaceuticals

Phase 3

17,004

Meppel, Doetinchem, Tiel, Nijmegen, Breda, Tilburg, Alkmaar, Amstelveen

2021-11-23

Recruiting

Anti-PD-1 and CapOx for the First-line Treatment of dMMR Esophagogastric Cancer (AuspiCiOus)

NCT05177133Gastric Adenocarcinoma, Esophageal Adenocarcinoma

DrugsRetifanlimab·Xeloda·Capecitabine·Oxaliplatin

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Phase 2

Amsterdam, Eindhoven, Leeuwarden, Leiden, Nijmegen, Rotterdam, Utrecht

2021-11-05

Active, closed

Induction Chemotherapy for Locally Advanced Rectal Cancer

NCT04838496Rectal Cancer

DrugFOLFOXIRI Protocol

Catharina Ziekenhuis Eindhoven

Phase 2

128

Eindhoven, Amsterdam, Geldrop, Helmond, Maastricht, Nijmegen, Rotterdam, Utrecht

2021-11-03

Recruiting

Oral Hedgehog Inhibitors in the Treatment of Basal Cell Carcinoma in the Netherlands: a Prospective Registration Study

NCT05463757Basal Cell Carcinoma, Locally Advanced Basal Cell Carcinoma, Metastatic Basal Cell Carcinoma, Gorlin Syndrome

DrugsSonidegib·Vismodegib

Maastricht University Medical Center

Observational

Nijmegen, Maastricht, Amsterdam, Groningen, Leiden, Rotterdam, Utrecht

2021-11-01

Active, closed

A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations

NCT05048797Locally Advanced or Metastatic Non-Small Cell Lung Cancer

DrugsTrastuzumab deruxtecan·Pemetrexed·Cisplatin·Carboplatin

AstraZeneca

Phase 3

454

Amsterdam, Groningen, Nijmegen

2021-10-28

Recruiting

First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)

NCT05099172Advanced Non-small Cell Lung Cancer, EGFR Mutation, HER2 Mutation

Bayer

Phase 1/2

430

Nijmegen, Amsterdam, Rotterdam

2021-10-25

Active, closed

A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma

NCT05083169Multiple Myeloma

DrugsTeclistamab·Pomalidomide·Bortezomib·Daratumumab

Janssen Research & Development, LLC

Phase 3

587

Amsterdam, Groningen, Nieuwegein, Nijmegen, Zwolle

2021-10-14

Active, closed

Percutaneous Coronary Intervention Before Transcatheter Aortic Valve Implantation

NCT05078619Valvular Heart Disease, Aortic Valve Stenosis, Coronary Artery Disease

UMC Utrecht

Not applicable

466

Nijmegen, Maastricht, Breda, Eindhoven, Amsterdam, Enschede, Leeuwarden, Groningen

2021-10-05

Active, closed

A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases

NCT04603807Carcinoma, Non-Small-Cell Lung

DrugsEntrectinib·Crizotinib

Hoffmann-La Roche

Phase 3

217

Amsterdam, Nijmegen, Rotterdam

2021-09-30

Active, closed

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis

NCT05050136Primary Biliary Cholangitis, PBC

DrugVolixibat

Mirum Pharmaceuticals, Inc.

Phase 2

333

Amsterdam, Nijmegen, Rotterdam

2021-09-22

Active, closed

The Value of a Risk Prediction Tool (PERSARC) for Effective Treatment Decisions of Soft-tissue Sarcomas Patients

NCT05741944Soft-tissue Sarcoma, Predictive Cancer Model

Leiden University Medical Center

Not applicable

120

Nijmegen, Maastricht, Amsterdam, Groningen, Leiden, Rotterdam, Utrecht

2021-08-24

Active, closed

A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy

NCT04923893Multiple Myeloma

DrugsCilta-cel·Bortezomib·Lenalidomide·Fludarabine

Janssen Research & Development, LLC

Phase 3

743

Amsterdam, Groningen, Nijmegen, Rotterdam

2021-08-19

Recruiting

Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases

NCT05003986Focal Segmental Glomerulosclerosis, Minimal Change Disease, Immunoglobulin A Nephropathy, IgA Vasculitis

DrugSparsentan

Travere Therapeutics, Inc.

Phase 2

Amsterdam, Nijmegen

2021-08-12

Recruiting

Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.

NCT04817618C3G

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

Leiden, Nijmegen

2021-07-28

Recruiting

Dutch National Randomized Study: PSMA-PET/CT As a Triage Tool for Pelvic Lymph Node Dissection in Prostatectomy Patients

NCT05000827Prostate Cancer Metastatic, Prostate Cancer, Lymph Node Metastases

Canisius-Wilhelmina Hospital

Not applicable

706

Nijmegen

2021-07-28

Active, closed

Long-term Safety and Tolerability of Iptacopan in Patients With Paroxysmal Nocturnal Hemoglobinuria

NCT04747613Paroxysmal Nocturnal Hemoglobinuria

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

208

Nijmegen

2021-07-27

Recruiting

Use of Physiology to Evaluate Procedural Result After PCI CTO

NCT04780971Percutaneous Coronary Revascularisation, Complex Coronary Lesion

Isala

Not applicable

200

Nijmegen, Zwolle

2021-07-21

Active, closed

Study on Prognosis of Acutely Ruptured Intracranial Aneurysms

NCT05851989Aneurysmal Subarachnoid Hemorrhage, Endovascular Procedures, Craniotomy, Patient Outcome Assessment

Haaglanden Medical Centre

Observational

880

Utrecht, Amsterdam, Maastricht, Nijmegen, Rotterdam, The Hague

2021-07-14

Active, closed

Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas

NCT04425967Soft Tissue Sarcomas

The Netherlands Cancer Institute

Not applicable

168

Groningen, Leiden, Nijmegen, Rotterdam

2021-06-25

Active, closed

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

NCT04793958Advanced Colorectal Cancer, Metastatic Colorectal Cancer

DrugsAdagrasib·MFOLFOX6·Erbitux·Folfox

Mirati Therapeutics Inc.

Phase 3

461

Amsterdam, Nijmegen, Utrecht

2021-06-24

Active, closed

Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

NCT04895358Breast Neoplasms

DrugsLiposomal doxorubicin·Abraxane·Xeloda·Taxol

Merck Sharp & Dohme LLC

Phase 3

342

Nijmegen, Maastricht, 's-Hertogenbosch, Tilburg, Amsterdam, Leiden, Leidschendam, Schiedam

2021-06-18

By invitation

Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

NCT04451044Coronary Artery Disease, Ischemic Heart Disease

Philips Clinical & Medical Affairs Global

Not applicable

3,212

Dordrecht, Enschede, Leeuwarden, Nieuwegein, Nijmegen

2021-06-17

Active, closed

An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With Standard of Care (SoC), Versus SoC Alone, in Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC)

NCT04720157Prostatic Neoplasms

DrugsARDT·Illuccix·Lu-PSMA

Novartis Pharmaceuticals

Phase 3

1,144

Maastricht, Delft, Nijmegen, Utrecht

2021-06-09

Active, closed

Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F

NCT04765345Retinal Degeneration, Retinitis Pigmentosa, Eye Diseases, Hereditary

Jaeb Center for Health Research

Observational

Nijmegen

2021-06-08

Recruiting

STEPWISE Parkinson: A Smartphone Based Exercise Solution for Patients With Parkinson's Disease

NCT04848077Movement Disorders, Parkinson Disease

Radboud University Medical Center

Not applicable

452

Nijmegen

2021-05-18

Active, closed

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

NCT07218029Pulmonary Arterial Hypertension

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 3

815

Nijmegen, Amsterdam

2021-05-12

Active, closed

Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).

NCT04372953Lung Injury, Preterm Birth

Murdoch Childrens Research Institute

Not applicable

906

Amsterdam, Nijmegen, Veldhoven

2021-05-04

Active, closed

Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum

NCT04589650PIK3CA-related Overgrowth Spectrum (PROS)

DrugAlpelisib

Novartis Pharmaceuticals

Phase 2

236

Nijmegen

2021-04-19

Recruiting

Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision

NCT05772923Organ Preservation, Rectal Cancer, Quality of Life, Locally Advanced Rectal Carcinoma

The Netherlands Cancer Institute

Not applicable

168

Nijmegen, Eindhoven, Amsterdam, Deventer, Zwolle, Leeuwarden, Capelle aan den IJssel

2021-04-16

Recruiting

Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).

NCT04663750Eye Diseases, Macular Degeneration, Wet, Sub-Macular Hemorrhage

King's College Hospital NHS Trust

Phase 3

210

Nijmegen, Rotterdam

2021-04-16

Active, closed

Study to Assess the Safety and Efficacy of Viltolarsen in Ambulant Boys With DMD (RACER53-X)

NCT04768062Duchenne Muscular Dystrophy

DrugViltolarsen

NS Pharma, Inc.

Phase 3

Leiden, Nijmegen

2021-04-13

Active, closed

Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment

NCT04647526Metastatic Castration-Resistant Prostate Cancer

DrugsAbiraterone·Enzalutamide

POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company

Phase 3

455

Nieuwegein, Nijmegen, Rotterdam

2021-02-25

Active, closed

Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

NCT04685135Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer

DrugsAdagrasib·Taxotere·Docetaxel

Mirati Therapeutics Inc.

Phase 3

453

Amsterdam, Breda, Maastricht, Nijmegen, The Hague, Utrecht

2021-02-23

Active, closed

Iberdomide Combined With Low-dose Cyclophosphamide and Dexamethasone

NCT04392037Multiple Myeloma

DrugIberdomide

Amsterdam UMC, location VUmc

Phase 2

Alkmaar, Amsterdam, Arnhem, Breda, Dordrecht, Groningen, Nieuwegein, Nijmegen

2021-02-17

Active, closed

Firehawk Rapamycin Target Eluting Coronary Stent North American Trial

NCT04562532Coronary Artery Disease

Shanghai MicroPort Medical (Group) Co., Ltd.

Not applicable

1,720

Nijmegen

2021-02-17

Recruiting

A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

NCT04901936Paroxysmal Nocturnal Hemoglobinuria (PNH), Paroxysmal Hemoglobinuria

DrugPegcetacoplan

Apellis Pharmaceuticals, Inc.

Phase 2

Nijmegen, Utrecht

2021-02-04

Recruiting

SCAD : a Registry of Spontaneous Coronary Artery Dissection

NCT06601270Spontaneous Coronary Artery Dissection

European Society of Cardiology

Observational

1,500

Alkmaar, Breda, Nijmegen

2021-01-30

Recruiting

Polycystic Liver Disease Registry (UK)

NCT04645251Polycystic Liver Disease

Portsmouth Hospitals NHS Trust

Observational

500

Nijmegen

2021-01-21

Recruiting

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

NCT04031677Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma

European Organisation for Research and Treatment of Cancer - EORTC

Phase 3

250

Amsterdam, Leiden, Nijmegen

2021-01-20

Active, closed

Dose Escalation Study of Immunomodulatory Nanoparticles

NCT04751786Advanced Solid Tumor

Radboud University Medical Center

Phase 1

Nijmegen

2021-01-11

Recruiting

Groningen International Study on Sentinel Nodes in Vulvar Cancer-III

NCT05076942Vulvar Cancer, Sentinel Lymph Node, Lymph Node Metastases

DrugCisplatin

University Medical Center Groningen

Phase 2

157

Eindhoven, Groningen, Leiden, Nijmegen, Rotterdam, Utrecht

2021-01-01

Recruiting

iCorMicA - Stratified Medicine in Angina

NCT04674449Microvascular Angina, Angina, Stable, Ischemia With No Obstructive Coronary Arteries (INOCA), Coronary Microvascular Dysfunction (CMD)

NHS Greater Glasgow and Clyde

Not applicable

1,500

Nijmegen

2020-12-30

Active, closed

Pullback Pressure Gradient (PPG) Global Registry

NCT04789317Chronic Coronary Insufficiency, Non ST Elevation Myocardial Infarction

VZW Cardiovascular Research Center Aalst

Observational

982

Eindhoven, Nijmegen

2020-12-23

Active, closed

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

NCT04663308Primary Sclerosing Cholangitis

DrugVolixibat

Mirum Pharmaceuticals, Inc.

Phase 2

182

Amsterdam, Groningen, Nijmegen, Rotterdam

2020-12-18

Active, closed

A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy

NCT04640623Urinary Bladder Neoplasms

DrugsTAR-200·Cetrelimab

Janssen Research & Development, LLC

Phase 2

220

Amsterdam, Eindhoven, Nijmegen, Utrecht

2020-12-18

Active, closed

FS222 First in Human Study in Patients With Advanced Malignancies

NCT04740424Advanced Cancer, Metastatic Cancer

invoX Pharma Limited

Phase 1

260

Nijmegen

2020-12-14

Active, closed

Efficacy Comparison of Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants With Advanced Non-small Cell Lung Cancer Who Have Progressed on Prior Anti-PD-(L)1 Therapy and Chemotherapy

NCT04655976Lung Cancer, Non-Small Cell

DrugsCobolimab·Dostarlimab·Docetaxel

GlaxoSmithKline

Phase 2/3

758

Amersfoort, Enschede, Groningen, Harderwijk, Nijmegen, Utrecht, Zwolle

2020-12-08

Active, closed

Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene

NCT04794101X-Linked Retinitis Pigmentosa

MeiraGTx Ocular UK Ltd

Phase 3

Amsterdam, Nijmegen

2020-12-04

Recruiting

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

NCT04613596Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer

DrugsAdagrasib·Pembrolizumab

Mirati Therapeutics Inc.

Phase 2/3

626

Amsterdam, Dordrecht, Harderwijk, Nijmegen, Rotterdam, The Hague, Utrecht, Zwolle

2020-12-02

Recruiting

LANDMARK Trial: a Randomised Controlled Trial of Myval THV

NCT04275726Aortic Valve Stenosis

Meril Life Sciences Pvt. Ltd.

Not applicable

988

Nieuwegein, Nijmegen, Zwolle, Amsterdam, Breda, Groningen, Utrecht

2020-11-04

Recruiting

South East (Zuid Oost) Netherlands Heart Registry

NCT06512493Coronary Artery Disease, Acute Coronary Syndrome, Chronic Coronary Syndrome

Radboud University Medical Center

Observational

99,999

Heerlen, Maastricht, Venlo, Nijmegen

2020-11-01

Recruiting

Distress In CErvical Cancer Patients and Partners

NCT04475354Cervical Cancer, Psychologic Stress, Psychological Distress, Survivorship

Comprehensive Cancer Centre The Netherlands

Observational

832

Breda, Eindhoven, Groningen, Maastricht, Nijmegen, Utrecht

2020-11-01

By invitation

The NetherLands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT)

NCT06083155Coronary Vasospasm, Coronary Microvascular Dysfunction, Non-Obstructive Coronary Atherosclerosis

Radboud University Medical Center

Observational

2,000

Nijmegen, Amsterdam, Arnhem, Breda, Eindhoven, Enschede, Hilversum, Leeuwarden

2020-10-15

Active, closed

Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer

NCT04590963Squamous Cell Carcinoma of the Head and Neck

DrugsMonalizumab·Erbitux·Cetuximab

AstraZeneca

Phase 3

370

Amsterdam, Maastricht, Nijmegen

2020-10-02

Active, closed

Study Comparing Intravenous (IV)/Subcutaneous (SC) Risankizumab to IV/SC Ustekinumab to Assess Change in Crohn's Disease Activity Index (CDAI) in Adult Participants With Moderate to Severe Crohn's Disease (CD)

NCT04524611Crohn's Disease (CD)

DrugsSkyrizi·Risankizumab·Ustekinumab

AbbVie

Phase 3

527

Nijmegen, Tilburg, Amsterdam, Utrecht

2020-09-30

Active, closed

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT04487080Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab·Osimertinib

Janssen Research & Development, LLC

Phase 3

1,074

's-Hertogenbosch, Arnhem, Harderwijk, Nijmegen

2020-09-30

Active, closed

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC)

NCT04497844Prostatic Neoplasms

DrugsAbiraterone acetate·Prednisone

Janssen Research & Development, LLC

Phase 3

696

Delft, Hilversum, Nijmegen, Tilburg

2020-09-23

Recruiting

PSMA-PET Guided Hypofractionated Salvage Prostate Bed Radiotherapy

NCT04642027Prostate Cancer, Cancer Recurrence

University Medical Center Groningen

Phase 3

538

Arnhem, Nijmegen, Maastricht, Eindhoven, Tilburg, Amsterdam, Deventer, Leeuwarden

2020-09-01

Active, closed

The Personalized Parkinson Project De Novo Cohort

NCT04985539Parkinson Disease, Parkinsonian Disorders, Basal Ganglia Diseases, Brain Diseases

Radboud University Medical Center

Observational

103

Nijmegen

2020-08-29

Active, closed

A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Duchenne Muscular Dystrophy (DMD) (MIS51ON)

NCT03992430Muscular Dystrophy, Duchenne

DrugEteplirsen

Sarepta Therapeutics, Inc.

Phase 3

160

Leiden, Nijmegen

2020-07-13

Recruiting

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

NCT04477785Parkinson Disease

Michael J. Fox Foundation for Parkinson's Research

Observational

4,500

Nijmegen

2020-07-01

Active, closed

Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

NCT04273945Pulmonary Arterial Hypertension

DrugMacitentan

Actelion

Phase 3

935

Amsterdam, Nieuwegein, Nijmegen, Rotterdam

2020-06-30

Active, closed

Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC

NCT04295811Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia

Lucid Diagnostics, Inc.

Not applicable

784

Amsterdam, Eindhoven, Groningen, Nieuwegein, Nijmegen, Rotterdam

2020-06-18

Recruiting

Doxapram Therapy in Preterm Infants (DOXA Trial)

NCT04430790Apnea of Prematurity, Respiratory Insufficiency

DrugDoxapram

Erasmus Medical Center

Phase 3

396

Nijmegen, Maastricht, Veldhoven, Amsterdam, Zwolle, Leiden, Rotterdam, Groningen

2020-06-15

Recruiting

Tonometry(1) and Duplex Ultrasound(2) to Predict CV Events in to be Treated Patients With an AAA

NCT04183426Abdominal Aortic Aneurysm, Cardiovascular Events

Rijnstate Hospital

Observational

194

Nijmegen, Apeldoorn, Deventer, Ede, Enschede, Veldhoven

2020-06-12

Active, closed

Hypofractionated Focal Lesion Ablative Microboost in prostatE Cancer 2.0

NCT04045717Prostate Adenocarcinoma, Prostate Cancer, Prostate Neoplasm

Universitaire Ziekenhuizen KU Leuven

Phase 2

124

Amsterdam, Nijmegen

2020-04-10

Active, closed

Androgen Deprivation Therapy for Oligo-recurrent Prostate Cancer in Addition to radioTherapy

NCT04302454Prostate Cancer

DrugsEligard·Leuprorelin

University Medical Center Groningen

Phase 3

280

Arnhem, Nijmegen, Maastricht, Eindhoven, Amsterdam, Deventer, Zwolle, Leeuwarden

2020-03-19

Recruiting

The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study

NCT04204915Aortic Stenosis

University of Leicester

Not applicable

2,104

Leeuwarden, Nijmegen

2020-03-10

Recruiting

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

NCT04294927BRCA1 Gene Mutation, BRCA2 Gene Mutation, RAD51C Gene Mutation, RAD51D Gene Mutation

University Medical Center Nijmegen

Not applicable

3,000

Nijmegen, Maastricht, Eindhoven, Tilburg, Amsterdam, Breda, Enschede, Groningen

2020-03-01

Active, closed

Rate of Progression in EYS Related Retinal Degeneration

NCT04127006Retinitis Pigmentosa, Eye Diseases

Jaeb Center for Health Research

Observational

103

Nijmegen

2020-02-25

Recruiting

Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass

NCT04217421Congenital Heart Disease in Children, Neuroprotection

DrugsAllopurinol·Mannitol

dr. M.J.N.L. Benders

Phase 3

236

Groningen, Nijmegen, Rotterdam, Utrecht

2020-02-14

Recruiting

Prevention of Post-TIPS Hepatic Encephalopathy by Administration of Rifaximin and Lactulose

NCT04073290Hepatic Encephalopathy, Cirrhosis, Liver, Portal Hypertension, Liver Diseases

DrugsLactulose·Rifaximin

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Phase 4

238

Amsterdam, Groningen, Leiden, Nijmegen, Rotterdam

2020-01-21

Active, closed

A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib

NCT04170283B-cell Malignancies

DrugsZanubrutinib·Tislelizumab

BeOne Medicines

Phase 3

955

Amsterdam, Nijmegen, Utrecht

2020-01-16

Active, closed

Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

NCT03772028Ovarian Cancer

DrugCisplatin

The Netherlands Cancer Institute

Phase 3

538

Amsterdam, Eindhoven, Enschede, Groningen, Leiden, Maastricht, Nijmegen, Rotterdam

2020-01-01

Active, closed

Natural Course of Pain Following Surgery Through an Abdominal Incision

NCT04088838Adhesions Abdominal, Adhesions Pelvic, Surgery Induced Tissue Adhesions, Chronic Pain

Radboud University Medical Center

Observational

650

Boxmeer, Nijmegen, Maastricht, Arnhem, Doetinchem, Ede

2020-01-01

Active, closed

Safety and Efficacy of Silk Vista and Silk Vista Baby Flow Diverter for Intracranial Aneurysm Treatment

NCT04034810Intracranial Aneurysm, Flow Diverter

Balt Extrusion

Observational

234

Nijmegen

2019-11-04

Active, closed

Efficacy of Diltiazem to Improve Coronary Microvascular Dysfunction: a Randomized Clinical Trial

NCT04777045Microvascular Angina, Coronary Vasospasm, Microvascular Ischemia of Myocardium

Radboud University Medical Center

Phase 3

Nijmegen, Eindhoven, Rotterdam

2019-10-25

Active, closed

Beta Cell Imaging During and Shortly After the Honeymoon Phase of T1D

NCT03917238Type 1 Diabetes Mellitus

Radboud University Medical Center

Not applicable

Nijmegen, Rotterdam

2019-10-11

Active, closed

A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis

NCT04033445Ulcerative Colitis

DrugGuselkumab

Janssen Research & Development, LLC

Phase 2/3

1,064

Amsterdam, Dordrecht, Nijmegen

2019-09-26

Recruiting

Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder Cancer

NCT03379909Superficial Bladder Cancer, Bladder Cancer

DrugMetformin

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Phase 2

Nijmegen, Rotterdam, Amsterdam

2019-09-01

Active, closed

A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation

NCT04002297Mantle Cell Lymphoma; Non-Hodgkin Lymphoma

DrugsBendamustine·Zanubrutinib·Rituximab

BeOne Medicines

Phase 3

510

Goes, Groningen, Nieuwegein, Nijmegen, Rotterdam, The Hague

2019-08-20

Active, closed

Very Early PET-response Adapted Targeted Therapy for Advanced Hodgkin Lymphoma: a Single -Arm Phase II Study

NCT03517137Advanced Hodgkin Lymphoma

DrugsVinblastine·Brentuximab Vedotin·Dacarbazine·Adriamycin

European Organisation for Research and Treatment of Cancer - EORTC

Phase 2

150

Amsterdam, Deventer, Groningen, Leeuwarden, Leidschendam, Nijmegen, Rotterdam

2019-08-01

Active, closed

RCT Comparing Immunosuppressive Regimens in Elderly Renal Transplant Recipients

NCT03797196Renal Transplant Recipients, Elderly Patients, Immunosuppression

DrugsTacrolimus·Everolimus

University Medical Center Groningen

Phase 4

374

Amsterdam, Groningen, Leiden, Nijmegen, Rotterdam, Utrecht

2019-07-29

Recruiting

Registration Study Sarcoma

NCT05373810Sarcoma

Radboud University Medical Center

Observational

1,000

Arnhem, Nijmegen

2019-07-29

Active, closed

Long Term Follow-up After Primary or Revision Shoulder Arthroplasty With a Patient- Specific Glenius Implant

NCT03806881Arthroplasty, Replacement, Shoulder, Glenoid Cavity, Osteoarthritis of the Shoulder

Materialise

Observational

Nijmegen

2019-07-01

Active, closed

Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)

NCT03944772Non-Small Cell Lung Cancer

DrugsNecitumumab·Gefitinib·Savolitinib·Selpercatinib

AstraZeneca

Phase 2

247

Amsterdam, Maastricht, Nijmegen, Rotterdam

2019-06-25

Recruiting

E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe

NCT03818503Cancer

European Organisation for Research and Treatment of Cancer - EORTC

Observational

2,000

Eindhoven, Groningen, Nijmegen

2019-06-24

Active, closed

A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

NCT03767244Prostatic Neoplasms

DrugApalutamide

Janssen Research & Development, LLC

Phase 3

2,517

Amsterdam, Eindhoven, Nieuwegein, Nijmegen

2019-06-11

By invitation

Prospective Registry on Intravascular Lithotripsy

NCT06577038Calcific Coronary Arteriosclerosis

Leiden University Medical Center

Observational

1,000

Amsterdam, Leiden, 's-Hertogenbosch, Arnhem, Leeuwarden, Nijmegen

2019-05-01

Active, closed

Follow-up in Gynecological Cancer Survivors

NCT03515993Gynecologic Cancer

European Organisation for Research and Treatment of Cancer - EORTC

Observational

1,100

Nijmegen, Utrecht

2019-02-21

Recruiting

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

NCT04075305Oncology, Breast Cancer, Prostate Cancer, Gynecologic Cancer

UMC Utrecht

Observational

8,000

Amsterdam, Deventer, Leeuwarden, Nijmegen, Utrecht

2019-02-01

Active, closed

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

NCT03748641Castration-Resistant Prostatic Cancer

DrugsAbiraterone acetate·Niraparib·Prednisone

Janssen Research & Development, LLC

Phase 3

765

Amsterdam, Groningen, Leidschendam, Nieuwegein, Nijmegen, Rotterdam, Sittard-Geleen

2019-01-25

Active, closed

PeRcutaneous cOronary Intervention of Native Coronary arTery Versus Venous Bypass Graft in Patients With Prior CABG

NCT03805048Coronary Artery Disease

Amsterdam UMC, location VUmc

Not applicable

221

Amsterdam, Breda, Eindhoven, Leeuwarden, Nieuwegein, Nijmegen, Utrecht

2019-01-22

Active, closed

A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve

NCT03682536Myelodysplastic Syndromes

DrugsEpoetin Alfa·Luspatercept

Celgene

Phase 3

363

Amsterdam, Nijmegen, Rotterdam, Sittard-Geleen, The Hague

2019-01-02

Recruiting

Estab Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1)

NCT03981575Myotonic Dystrophy 1, DM1

Virginia Commonwealth University

Observational

700

Nijmegen

2019-01-01

Active, closed

A Study of Neoadjuvant/Adjuvant Durvalumab for the Treatment of Patients With Resectable Non-small Cell Lung Cancer

NCT03800134Non-Small Cell Lung Cancer

DrugsDurvalumab·Pemetrexed·Gemcitabine·Paclitaxel

AstraZeneca

Phase 3

825

Arnhem, Nijmegen

2018-12-06

Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Dutch investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 13 November 2026. https://priyalifescience.com/clinical-trials-netherlands/city/nijmegen

Query this register directly

GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Netherlands and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 3,171 studies in total at the last sync on 10 Nov 2026, 03:17 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 565 of those studies with a site in Nijmegen.

How many clinical trials are recruiting in Nijmegen?

322 of the 565 studies on this page are recruiting new participants as of the 10 Nov 2026, 03:17 UTC sync. A further 27 have not yet opened recruitment, 204 are active but closed to new participants, and 12 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Nijmegen), 565 studies
Phase	Studies	Recruiting	Share
Phase 3	197	105	34.9%
Observational	109	61	19.3%
Not applicable	101	60	17.9%
Phase 2	66	36	11.7%
Phase 4	25	21	4.4%
Phase 1/2	23	17	4.1%
Phase 1	22	10	3.9%
Phase 2/3	21	11	3.7%
Early Phase 1	1	1	0.2%

Most active sponsors

Lead sponsors with the most studies (Nijmegen)
Lead sponsor	Studies	Recruiting
Radboud University Medical Center	100	57
Merck Sharp & Dohme LLC	24	13
Janssen Research & Development, LLC	22	10
University Medical Center Groningen	18	11
AstraZeneca	17	4
Novartis Pharmaceuticals	13	6
AbbVie	11	3
Eli Lilly and Company	10	8
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	9	8
The Netherlands Cancer Institute	9	5

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.