TMS for Exposure Therapy Resistant OCD
Condition(s) studied
Investigational drug(s) / intervention(s)
repetitive transcranial magnetic stimulation (rTMS): rTMS (real versus sham) is used as adjuvant to ERP
Study summary
TETRO is a multi-center placebo-controlled double-blind randomized controlled trial with an intervention phase of 5-7 weeks and a follow-up phase of 12 months in 250 adult (18 years and older) OCD patients who show no/insufficient response to ERP, aiming to establish the cost-effectiveness of low frequency (1 Hz) rTMS to the pre-SMA (compared to sham rTMS to the pre-SMA) as adjuvant treatment to exposure with response prevention (ERP). The treatment consists of 4 times/week rTMS combined with ERP for at least 5 weeks (20 sessions), with optional extension phase of 1 or 2 weeks (maximum of 28 sessions in total).
Eligibility
Primary outcome measure(s)
- Y-BOCS — The primary endpoint is the difference between the active and sham intervention groups in post-treatment severity of OCD, estimated using an ANCOVA model that adjusts for pre-treatment severity of OCD.
The severity of OCD as measured by the Yale-Brown Obsessive-Compulsive Scale Y-BOCS I
Trial sites (8)
| Facility | City | Region | Status |
|---|---|---|---|
| Amsterdam UMC, location VU Medical Center | Amsterdam | North Holland | Recruiting |
| GGZ inGeest | Amsterdam | Netherlands | Recruiting |
| Neurocare | Eindhoven | Netherlands | Not Yet Recruiting |
| Neurocare | Groningen | Netherlands | Not Yet Recruiting |
| Maastricht UMC+ | Maastricht | Netherlands | Not Yet Recruiting |
| Mondriaan | Maastricht | Netherlands | Not Yet Recruiting |
| ProPersona | Nijmegen | Netherlands | Not Yet Recruiting |
| Radboudumc | Nijmegen | Netherlands | Not Yet Recruiting |
More Amsterdam UMC, location VUmc trials in the Netherlands
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05331937 on ClinicalTrials.gov ↗ ← All trials in the Netherlands