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Compound · clinical trials

Progesterone clinical trials

Also listed in trial records as Progiron, Uterogestane, Endometrin, Crinon
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 9 trials in our China, France, Spain, Netherlands, Belgium, Denmark, Japan, Israel and Egypt registers that name Progesterone as an intervention. Synced 26 Sep 2026
9Current trials
7Recruiting now
9Lead sponsors
9Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Progesterone is named as an intervention in 9 current clinical trials in our China, France, Spain, Netherlands, Belgium, Denmark, Japan, Israel and Egypt registers. 7 are recruiting patients now. The most common phase is Phase 4. The sponsor with the most trials is West China Second University Hospital (1). The most-studied condition is Infertility. The EU clinical trials register (CTIS) separately lists 3 authorised or ongoing trials.

Trials by status

  • Recruiting778%
  • Not yet open222%

Trials by phase

  • Phase 4333%
  • Phase 3222%
  • Observational222%
  • Phase 2/3111%
  • Not applicable111%
01

Clinical trials of Progesterone

9 trials
StudyPhaseStatusLead sponsorRegisters
Impact of the Presence of the Corpus Luteum on Pregnancies Obtained Through Frozen Embryo Transfer(FET)
NCT06896617 · ClinicalTrials.gov ↗ · Infertilities, Embryo Transfer
Phase 4 Recruiting Fundacion Clinic per a la Recerca Biomรฉdica Spain
Progesterone Supplementation After Letrozole-stimulated Insemination
NCT07508657 · ClinicalTrials.gov ↗ · Infertility
Phase 4 Recruiting Kirstine Kirkegaard Denmark
A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA)
NCT07340827 · ClinicalTrials.gov ↗ · Infertility
Phase 3 Recruiting Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Japan
Value of LNG-IUS as Fertility-preserving Treatment of EAH and EC
NCT03463252 · ClinicalTrials.gov ↗ · Endometrial Cancer, Atypical Endometrial Hyperplasia
Phase 2/3 Recruiting West China Second University Hospital China
PROMOTE Study: Prediction of Response Of HorMOnal Treatment in Advanced and Recurrent Endometrial Cancer
NCT03621904 · ClinicalTrials.gov ↗ · Endometrial Cancer Stage III, Endometrial Cancer Stage IV, Endometrial Cancer Recurrent
Observational Recruiting Radboud University Medical Center Netherlands
GnRH for Luteal Support - Mechanism of Action
NCT07620067 · ClinicalTrials.gov ↗ · GnRH Antagonist IVF Protocol, Fresh Embryo Transfer, Administration of Hormonal Luteal Support
Observational Recruiting Heli Alexandroni Israel
Role of Low Dose Injectable Progesterone in Triggering Ovulation
NCT06928844 · ClinicalTrials.gov ↗ · Low Dose, Progesterone, Triggering Ovulation
Not applicable Recruiting The General Authority for Teaching Hospitals and Institutes Egypt
Cycle-to-cycle Variability of Progesterone in the Endometrium in Patients Undergoing an Euploid Blastocyst Transfer in a Hormone Replacement Therapy (HRT) Cycle (PROMICOFET)
NCT07818278 · ClinicalTrials.gov ↗ · Fertility, Implantation, Embryo
Phase 4 Not yet open University Hospital, Ghent Belgium
Individualized Prolonged Luteal Support After Fresh Embryo Transfer in Women With Low Progesterone
NCT07613528 · ClinicalTrials.gov ↗ · Pregnancy, Progesterone Supplementation, Low Serum Progesterone
Phase 3 Not yet open University Hospital, Montpellier France

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Progesterone in the EU trials register (CTIS)

3 trials

Authorised or ongoing trials in the EU Clinical Trials Information System that list a product containing Progesterone. Many trials are registered in both CTIS and ClinicalTrials.gov, so these are shown separately rather than added to the count above. Trials with a site in Ireland are listed first.

StudyPhaseStatusSponsorCountries
Effects of Menopausal Hormone Therapy on QTc in Genetically Confirmed Long QT Syndrome: A Prospective Randomized Sequential Crossover Study with Long-Term Observational Follow-Up (LQTS-HER)
2026-526442-28-00 · Cardiovascular Diseases
Phase 4 Authorised Oslo Universitetssykehus HF Norway
Progesterone Luteal Support in Unexplained Infertility Management (PLUIM study)
2026-525747-33-00 · CTIS ↗ · Reproductive and Urinary Physiological Phenomena
Phase 4 Authorised Universitair Medisch Centrum Utrecht Netherlands
The impact of ovarian stimulation with hMG on embryo quality in advanced age women. A randomized controlled trial
2025-524761-25-00 · CTIS ↗ · Female Urogenital Diseases and Pregnancy Complications
Phase 4 Authorised Santiago Dexeus Font Fundacio Privada Spain
03

Progesterone across our data

Ireland · EU · US

The same active substance in our other registers, matched by its exact name. Each entry links to the register record it comes from.

Licensed in Ireland (HPRA)

11 single-substance products containing Progesterone on the HPRA medicines list.

All 11 Irish products →

Supply shortages

No entry for Progesterone in the EMA, FDA or German BfArM shortage lists we track.

04

Conditions studied with Progesterone

19 conditions
Infertility2Endometrial Cancer1Atypical Endometrial Hyperplasia1Pregnancy1Progesterone Supplementation1Low Serum Progesterone1Infertilities1Embryo Transfer1Endometrial Cancer Stage III1Endometrial Cancer Stage IV1Endometrial Cancer Recurrent1Fertility1
All 19 conditions
Condition (as registered)Trials
Infertility2
Endometrial Cancer1
Atypical Endometrial Hyperplasia1
Pregnancy1
Progesterone Supplementation1
Low Serum Progesterone1
Infertilities1
Embryo Transfer1
Endometrial Cancer Stage III1
Endometrial Cancer Stage IV1
Endometrial Cancer Recurrent1
Fertility1
Implantation, Embryo1
GnRH Antagonist IVF Protocol1
Fresh Embryo Transfer1
Administration of Hormonal Luteal Support1
Low Dose1
Progesterone1
Triggering Ovulation1
05

Sponsors

lead sponsor per trial
Lead sponsorTrials
West China Second University Hospital1
University Hospital, Montpellier1
Fundacion Clinic per a la Recerca Biomรฉdica1
Radboud University Medical Center1
University Hospital, Ghent1
Kirstine Kirkegaard1
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany1
Heli Alexandroni1
The General Authority for Teaching Hospitals and Institutes1
06

By country register

RegisterTrialsRecruiting
Clinical trials in China11
Clinical trials in France10
Clinical trials in Spain11
Clinical trials in Netherlands11
Clinical trials in Belgium10
Clinical trials in Denmark11
Clinical trials in Japan11
Clinical trials in Israel11
Clinical trials in Egypt11
EU register (CTIS)3—

A trial with sites in more than one country appears in each of those registers. CTIS does not publish a recruiting flag; its trials may also appear in the registers above.

07

Related compounds

08

Questions about Progesterone trials

How many clinical trials are testing Progesterone?

9 current trials in our China, France, Spain, Netherlands, Belgium, Denmark, Japan, Israel and Egypt registers name Progesterone as a drug or biological intervention, as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Progesterone trials recruiting patients?

Yes. 7 of the 9 trials are recruiting: 1 with sites in China, 1 with sites in Spain, 1 with sites in Netherlands, 1 with sites in Denmark, 1 with sites in Japan, 1 with sites in Israel and 1 with sites in Egypt. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Progesterone clinical trials?

West China Second University Hospital (1), University Hospital, Montpellier (1), Fundacion Clinic per a la Recerca Biomรฉdica (1) and Radboud University Medical Center (1), among 9 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Is Progesterone licensed in Ireland?

Yes. The HPRA medicines list includes 11 single-substance products containing Progesterone, for example Crinone 8% w/w progesterone vaginal gel (Merck Serono (Ireland) Limited). A licence does not mean a product is currently marketed or reimbursed; see each product's record.

Is there a Progesterone shortage?

Not in the lists we track: Progesterone has no entry in the EMA, FDA or German BfArM shortage registers as of their latest sync.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Progesterone works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Progesterone works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Progesterone (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.