Clinical trial register · France

Clinical Trials in Poitiers, 2026

Every study on the ClinicalTrials.gov registry that lists a site in France and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 9731 matching records held by the registry are in this view. Synced 02 Nov 2026, 03:18 UTC

9731

Studies in scope

all four open statuses

6052

Recruiting now

open to new participants

1028

Lead sponsors

across recruiting studies

Top sites

Paris 2829 Lyon 1396 Bordeaux 1393 Marseille 1295 Lille 1283

Trials with a site in Poitiers

Status

Study

Lead sponsor

Phase

Enrol

Sites in France

Start

Not yet open

An Open-Label Study to Evaluate the Long-Term Safety and Efficacy of ALXN2220 in Adults With Transthyretin Amyloid Cardiomyopathy

NCT07789483Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

DrugCliramitug

Alexion Pharmaceuticals, Inc.

Phase 3

1,180

Bron, Chambray-lès-Tours, Créteil, Marseille, Montpellier, Paris, Pessac, Poitiers

2027-11-23

Not yet open

Implementation of Mobile Intensive Care Unit Ultrasound Based Management for Acute Dyspnea

NCT07852364Acute Dyspnea

Central Hospital, Nancy, France

Not applicable

800

Argenteuil, Clermont-Ferrand, Épagny, Lille, Mulhouse, Nancy, Paris, Poitiers

2027-01-10

Not yet open

Efficacy and Tolerance of THC 25: CBD 25 in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study

NCT06435299Pruritus

DrugCannabis oil

University Hospital, Brest

Phase 2

218

Angers, La Roche-sur-Yon, La Rochelle, Nantes, Poitiers, Tours

2027-01-01

Not yet open

What is the Role of the Exposome in Pulmonary Hypertension

NCT07172334Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Poitiers University Hospital

Observational

150

Bordeaux, Brest, Le Kremlin-Bicêtre, Lille, Lyon, Nancy, Poitiers, Saint-Etienne

2027-01

Not yet open

tDCS and Symptom Provocation in Treatment-Resistant OCD

NCT07429500Obsessive - Compulsive Disorder

Centre Hospitalier Henri Laborit

Not applicable

178

Angoulême, Limoges, Nantes, Poitiers, Rennes, Thouars

2026-12-01

Not yet open

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, Type 2 Diabetes, and Increased Cardiovascular Risk

NCT07900633Obesity, Overweight, Cardiovascular Diseases, Diabetes Mellitus, Type 2

DrugEloralintide

Eli Lilly and Company

Phase 3

3,000

Corbeil-Essonnes, La Tronche, Le Coudray, Nantes, Paris, Pierre-Bénite, Poitiers, Rouen

2026-12

Not yet open

Evaluation of a French Hospital Discharge Therapeutic Education Program by Nurses for Heart Failure Patient (EduSor)

NCT07706543Heart Failure

University Hospital, Clermont-Ferrand

Not applicable

412

Clermont-Ferrand, Poitiers, Vichy

2026-11-01

Not yet open

The Impact of Telemedicine, Using the Caller's Mobile Phone Camera, on the Quality of Care Provided to Adult Patients Contacting the 15 Centre for Acute Dyspnea

NCT07726628Dyspnea

Poitiers University Hospital

Not applicable

778

Angers, Bayonne, La Roche-sur-Yon, La Rochelle, Montpellier, Nancy, Poitiers, Rennes

2026-11

Not yet open

A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity

NCT07861100Cardiovascular Risk, Obesity

DrugZenagamtide

Novo Nordisk A/S

Phase 3

8,500

Chambray-lès-Tours, Le Coudray, Lille, Massy, Paris, Pessac, Poitiers, Quint-Fonsegrives

2026-10-26

Recruiting

Influence of Intermittent Hypoxia on Loop Gain in Healthy Subjects

NCT07409649Intermittent Hypoxia, Healthy Volunteers

Poitiers University Hospital

Not applicable

Poitiers

2026-10-20

Recruiting

Bundle Branch Pacing to Preserve Ejection Fraction in Atrial Fibrillation Trial

NCT07759700Permanent Atrial Fibrillation, Preserved Ejection Fraction

Poitiers University Hospital

Not applicable

642

Poitiers

2026-10-15

Not yet open

Evaluation of the Axomove Therapy Medical Device to Facilitate Adapted Physical Activity for Patients With Obesity

NCT07903025Obese Adults

Axomove

Not applicable

184

Dijon, Grenoble, Lille, Nice, Paris, Poitiers, Scy-Chazelles, Villeneuve-d'Ascq

2026-10-01

Recruiting

Bexmarilimab + Azacitidine Versus Placebo + Azacitidine in Participants With Treatment-naïve Higher-risk Myelodysplastic Syndromes

NCT07672769Higher Risk Myelodysplastic Syndromes

DrugsBexmarilimab·Azacitidine

Faron Pharmaceuticals Ltd

Phase 2

Bordeaux, Paris, Poitiers, Villejuif

2026-10

Recruiting

Impact on Prognosis of Increased Sleep Quality Obtained by Personalized Night-time Nursing Care in Critically Ill Patients

NCT07606495Intensive Care Unit (ICU), Sleep Disruption, Sleep Monitoring

Poitiers University Hospital

Not applicable

460

La Roche-sur-Yon, La Rochelle, Le Mans, Poitiers, Rennes, Saintes, Tours

2026-09-16

Recruiting

Saruparib in Combination With Physician's Choice of ARPI in Patients With mHSPC Previously Treated With Docetaxel or 177Lu-PSMA Therapy Without Disease Progression and PSA ≥ 0.2 ng/mL (EvoPAR-PR05)

NCT07711002Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

DrugsSaruparib·Abiraterone·Darolutamide·Enzalutamide

AstraZeneca

Phase 3

1,330

Angers, Caen, Montpellier, Paris, Poitiers

2026-09-15

Recruiting

A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia

NCT07623200Essential Thrombocythemia

DrugINCA033989

Incyte Corporation

Phase 3

426

Amiens, Bordeaux, Brest, Créteil, Le Kremlin-Bicêtre, Nice, Paris, Poitiers

2026-09-08

Not yet open

Evaluation of the Clinical Value of NT-proBNP (or BNP) Measurement, Alone or in Combination With the EPOF Questionnaire, for the Screening of Chronic Heart Failure (CHF) in Adults Aged 40 Years and Older Referred for a Cardiology Consultation Without Suspected CHF.

NCT07837349NT-pro-BNP, NT-proBNP, CHF, Chronic Heart Failure

French Cardiology Society

Observational

1,000

Nîmes, Poitiers

2026-09

Recruiting

Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment

NCT07691970Systemic Sclerosis Cutaneous Lupus E Myopathies Systemic Lupus Erythematosus

DrugAnifrolumab

AstraZeneca

Phase 3

1,072

Bordeaux, Nantes, Paris, Poitiers, Rennes, Strasbourg, Toulouse

2026-08-31

Recruiting

Reducing Mental Health Stigmatization Among Healthcare Workers and Students Using a Virtual Reality Protocol: The VIRTUS Protocol

NCT07375199Schizophrenia Disorder

Centre Hospitalier Henri Laborit

Not applicable

128

Poitiers, Thouars

2026-08-17

Recruiting

ENDometriosis: Evaluation of Detection and Need for ALGOlogic Care Before Surgery

NCT06997809Endometriosis, Pain

University Hospital, Limoges

Not applicable

187

Bordeaux, Le Chesnay, Lille, Limoges, Poissy, Poitiers, Rennes

2026-08-05

Recruiting

Evaluation of the Efficacy and Safety of Magnetic Resonance Angiography (MRA) Using Gadopiclenol Compared to Gadoterate Meglumine in the Assessment of Steno-occlusive Disease in Adult Patients With Suspected Vascular Disease

NCT07348640Steno-occlusive Disease

DrugGadoterate meglumine

Guerbet

Phase 3

315

Bordeaux, Bron, Dijon, Poitiers

2026-07-28

Recruiting

An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC

NCT07720284High-risk Muscle Invasive Urothelial Carcinoma

DrugsRilvegostomig·Enfortumab Vedotin·Dato-DXd·Opdivo

AstraZeneca

Phase 3

915

Bordeaux, Montpellier, Paris, Pierre-Bénite, Poitiers, Strasbourg

2026-07-16

Recruiting

Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease

NCT07274254Vaso-Occlusive Pain Episode in Sickle Cell Disease

DrugLidocain

Nantes University Hospital

Phase 3

104

Bordeaux, Lille, Marseille, Nantes, Orléans, Paris, Poitiers, Rouen

2026-07-03

Not yet open

Strategies for Weaning From External Ventricular Drainage

NCT07630051Subarachnoid Hemorrhage, Hydrocephalus, Intracranial Hypertension, External Ventricular Drainage

University Hospital, Angers

Not applicable

170

Angers, Brest, Nantes, Poitiers, Rennes

2026-07-01

Recruiting

Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT

NCT07764978Newly Diagnosed Multiple Myeloma

DrugsAZD0120·Isatuximab·Bortezomib·Daratumumab

AstraZeneca

Phase 3

750

Lille, Nantes, Paris, Poitiers, Toulouse

2026-06-26

Recruiting

Comparing UDCA and Corticosteroids in Immunotherapy Induced Cholestatic Hepatitis

NCT07378761Immune-Mediated Cholestasis

DrugUDCA

University Hospital, Montpellier

Phase 2

Bordeaux, Lyon, Montpellier, Paris, Poitiers, Toulouse

2026-06-25

Recruiting

Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma

NCT07555938Multiple Myeloma

DrugsCevostamab·Elotuzumab·Carfilzomib·Pomalidomide

Hoffmann-La Roche

Phase 3

380

Nantes, Lille, Pierre-Benite (Lyon), Poitiers, Toulouse

2026-06-23

Recruiting

Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis

NCT06114667Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis, Respiratory Failure With Hypercapnia

University Hospital, Montpellier

Not applicable

174

Montpellier, Nîmes, Poitiers

2026-06-16

Not yet open

Confirmation of the Link Between Endocrine Disruptors Exposure and Breast Cancer and Identification of Biological Response Biomarkers

NCT07411651Breast Cancer, Endocrine Disruptors, Metabolomics, Breast Lesions

Poitiers University Hospital

Not applicable

Poitiers

2026-06-01

Not yet open

Research for Resistance Factors in the Treatment of Lymphoid Hemopathy

NCT07385612MATURE B-CELL LYMPHOIDS

Nantes University Hospital

Observational

La Roche-sur-Yon, Nantes, Poitiers, Saint-Nazaire

2026-06-01

Recruiting

Reducing Burnout in Healthcare Workers Through Yoga and Square Breathing Practices

NCT07166510Burn-Out

Poitiers University Hospital

Not applicable

Bordeaux, Poitiers

2026-06

Recruiting

A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT07518186Multiple Myeloma

DrugsRamantamig·Teclistamab

Janssen Research & Development, LLC

Phase 3

700

Amiens, Lyon, Montpellier, Nantes, Poitiers, Talence, Toulouse, Tours

2026-05-31

Recruiting

A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)

NCT07357727Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (PPV-MF), Post-essential Thrombocythemia Myelofibrosis (PET-MF)

DrugsPelabresib·Ruxolitinib

Novartis Pharmaceuticals

Phase 3

460

Brest, Le Kremlin-Bicêtre, Lens, Nîmes, Paris, Pessac, Poitiers, Rennes

2026-05-27

Recruiting

A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Lower Risk Myelodysplastic Syndromes (LR-MDS) Who Need Regular Blood Transfusions

NCT07422480Myelodysplastic Syndrome, Anemia

DrugsElritercept·Epoetin Alfa

Takeda

Phase 3

300

La Tronche, Poitiers, Villejuif, Nice, Paris

2026-05-21

Not yet open

A Randomized Non-Inferiority Study of Mepi™ Press 2 vs UrgoK2® for Compression Therapy in Venous Leg Ulcers

NCT07600489Venous Leg Ulcer (VLU), Compression Bandages

Molnlycke Health Care AB

Not applicable

386

Castelnau-le-Lez, Grenoble, Lyon, Nantes, Poitiers, Toulouse

2026-05

Recruiting

Study to Determine the Efficacy and Safety of Asciminib in Pediatric Patients With Ph+ CML-CP

NCT07354074Chronic Myelogenous Leukemia, Leukemia, Myelogenous, Chronic, Philadelphia Chromosome Positive

DrugsAsciminib single agent·ABL001

Novartis Pharmaceuticals

Phase 2

Marseille, Paris, Poitiers, Strasbourg

2026-04-28

Active, closed

AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

NCT07503210Obesity

DrugNNC0487-0111

Novo Nordisk A/S

Phase 3

606

Clermont-Ferrand, La Tronche, Le Creusot, Lille, Poitiers

2026-04-21

Recruiting

Optimisation of High Flow Oxygen Therapy Settings During Hypoxaemic Respiratory Distress Based on Non-contact Measurement of Lung Volumes by Depth Camera

NCT06819644Hypoxemic Respiratory Failure

University Hospital, Brest

Phase 3

406

Brest, Colombes, Créteil, Morlaix, Orléans, Poitiers, Rennes, Tours

2026-04-08

Active, closed

Cardiorespiratory Assessment Prior to Scoliosis Surgery: a 10-year Experience at a Specialized Scoliosis Center

NCT07760441Scoliosis, Restrictive Pulmonary Disease, Pulmonary Hypertension, Restrictive Breathing Pattern

Poitiers University Hospital

Observational

174

Poitiers

2026-04-01

Recruiting

A 2-part Phase 1/2 Open-label Trial on ODM-212

NCT07563738Mesothelioma, Pancreatic Cancer, NSCLC (Advanced Non-small Cell Lung Cancer)

DrugsODM-212·Gemcitabine and nab-paclitaxel·Ipilimumab and nivolumab·Sotorasib

Orion Corporation, Orion Pharma

Phase 1/2

229

Bordeaux, Marseille, Poitiers, Villejuif

2026-03-27

Recruiting

Transition to KPL-387 Monotherapy Dosing & Administration Study

NCT07288216Recurrent Pericarditis, Heart Diseases, Pericarditis

DrugKPL-387

Kiniksa Pharmaceuticals International, plc

Phase 2

120

Paris, Poitiers, Toulouse

2026-03-25

Recruiting

Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure

NCT07219459Unresectable or Metastatic Hepatocellular Carcinoma, Child-Pugh A Hepatocellular Carcinoma, Failure of First-Line Treatment That Included an Approved Anti PD-(L)1 Compound

DrugsVisugromab RDE·Opdivo·Lenvatinib·Nivolumab

CatalYm GmbH

Phase 2

104

Pessac, Poitiers, Villejuif

2026-03-19

Recruiting

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

NCT07351045Obesity or Overweight

Hoffmann-La Roche

Phase 3

2,000

Angers, Bois-Guillaume, Dijon, Paris, Pessac, Pierre-Bénite, Poitiers, Saint-Herblain

2026-03-16

Not yet open

Prognostic Factors of Hospitalization for Patients Aged 75 and Over in Emergency Department in France - Monocentric Retrospective Cohort Study

NCT07475442Elderly, Emergency Departments, Prognostic Factors, Hospitalizations

Poitiers University Hospital

Observational

967

Poitiers

2026-03-15

Recruiting

Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology

NCT07408375Solid Tumor (Excluding CNS)

Nantes University Hospital

Not applicable

560

Lyon, Nantes, Nîmes, Paris, Poitiers, Saint-Herblain, Villejuif

2026-03-13

Recruiting

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

NCT07221149Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

DrugsPumitamig·Folfox·Nivolumab

Bristol-Myers Squibb

Phase 2/3

690

Lyon Cedex08, Brest, Lille, Nantes, Poitiers, Marseille, Paris

2026-03-13

Recruiting

Prospective National Cohort Evaluating Prognostic Factors for Efficacy of Fruquintinib Treatment in Patients With Metastatic Colorectal Cancer

NCT07124858Metastatic Colorectal Cancer (CRC), Antineoplastic Agents, Immunological, VEGFR-TKI

DrugFruquintinib

Federation Francophone de Cancerologie Digestive

Not applicable

300

Poitiers, Albi, Amiens, Annecy, Aurillac, Bayeux, Bayonne, Beauvais

2026-03-10

Recruiting

Effect of Isometric Handgrip Exercise on Blood Pressure in Pregnant Women

NCT07607795Pregnancy, Pregnancy - Prenatal Testing, Hypertension (HTN)

University of Poitiers

Not applicable

Poitiers

2026-03-06

Recruiting

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

NCT07284849CRC (Colorectal Cancer)

DrugsINCA33890·Folfox·Bevacizumab

Incyte Corporation

Phase 3

700

Angers, Bordeaux, Marseille, Paris, Poitiers, Reims, Saint-Etienne, Toulouse

2026-03-05

Recruiting

Impact of Virtual Reality on Patient Pain During Lower Limb Revascularization Via Endovascular Surgery Under Local Anesthesia With Sedation

NCT07181434Peripheral Arterial Disease

Poitiers University Hospital

Not applicable

Poitiers

2026-03-03

Active, closed

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

NCT07288398Pulmonary Hypertension Associated With HFpEF

DrugTNX-103

Tenax Therapeutics, Inc.

Phase 3

540

Le Kremlin-Bicêtre, Montpellier, Nantes, Nice, Pau, Poitiers

2026-03-03

Recruiting

Alpha Radiation Emitters Device (DaRT) for the Treatment of Locally Advanced Pancreatic Cancer

NCT06755359Pancreatic Cancer, Locally Advanced Pancreatic Cancer

Alpha Tau Medical LTD.

Not applicable

Bordeaux, Clermont-Ferrand, Dijon, Grenoble, Lyon, Marseille, Poitiers, Villejuif

2026-03-01

Not yet open

The Efficacy of Combining Music Intervention With Nicotine Replacement Therapy to Reduce Smoking Craving, Among Healthcare Professionals Who Are Trying to Quit.

NCT07412717Nicotine Replacement Therapy, Healthcare Professionals, Tobacco Craving, Tabacco Cessation

Poitiers University Hospital

Not applicable

Poitiers

2026-03-01

Recruiting

A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

NCT07391657Relapsed Refractory Multiple Myeloma

DrugsAZD0120·Darzalex·Velcade·Carfilzomib

AstraZeneca

Phase 3

508

Lille, Nantes, Paris, Pierre-Bénite, Poitiers, Toulouse

2026-02-23

Recruiting

CAR-T Immunomonitoring in Multiple Myeloma (CART I5M)

NCT07342179Multiple Myeloma (MM)

Poitiers University Hospital

Not applicable

Poitiers

2026-02-13

Recruiting

Evaluation of the Efficacy of STNS With FAST and MULTIWAVE in Patients With Refractory Chronic Neuropathic Pain

NCT07154056Chronic Neuropathic Pain

Poitiers University Hospital

Not applicable

Poitiers

2026-02-10

Recruiting

A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma

NCT07258511Multiple Myeloma

DrugsRamantamig·Teclistamab

Janssen Research & Development, LLC

Phase 3

400

Lille, Lyon, Nancy, Nantes, Paris, Pessac, Poitiers, Toulouse

2026-02-04

Recruiting

B-GLUCANCER2 : A Pilot Study Evaluating a New Method for Cancer Detection by Measuring the Activity of Different Glycosidase Enzymes in the Plasma of Patients With a Localized Cancer.

NCT07236177Breast Cancer, Pancreatic Cancer, Pulmonary Cancer, Volatile Organic Compound

DrugBlood sampling

Poitiers University Hospital

Early Phase 1

220

Poitiers

2026-02-03

Not yet open

Evaluation of the Added Value of Logotherapy in the Psychological Support of Patients With Primary Breast Cancer

NCT07267572Breast Cancer

Elsan

Not applicable

Poitiers

2026-02-01

Recruiting

Assessment of the Association Between Sleep Disorders Detected by a Simplified Questionnaire and Cardiovascular Diseases

NCT07432828Sleep Disorder (Disorder), Cardio Vascular Disease

French Cardiology Society

Observational

1,500

Carquefou, Poitiers

2026-01-15

Recruiting

Functional Impact of Acute Respiratory Viral Infections in Older Adults

NCT07388173Respiratory Infections in Old Age

University Hospital, Grenoble

Observational

1,600

Amiens, Melun, Paris, Poitiers, Reims, Tours

2026-01-15

Recruiting

A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant

NCT07095452Multiple Myeloma

DrugsEtentamig·Daratumumab·Lenalidomide·Dexamethasone

AbbVie

Phase 2/3

680

Epagny Metz Tessy, Dunkirk, Lille, Montpellier, Tours, Vannes, Pessac, Poitiers

2026-01-08

Recruiting

Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

NCT07179380Pulmonary Hypertension, Interstitial Lung Disease

DrugTreprostinil Palmitil

Insmed Incorporated

Phase 3

344

Nice, Marseille, Angers, Lille, Saint Priest En Jarez, Le Kremlin-Bicêtre, Poitiers, Brest

2026-01-07

Not yet open

Impact on Mortality of Hospitalisation of a Patient in a Hospital Bed That Does Not Correspond to His Needs After a Visit to the Emergency Department

NCT07347847Emergency Department Patient

Rennes University Hospital

Observational

2,766

Angers, Le Mans, Nantes, Poitiers, Strasbourg, Toulouse, Tours

2026-01

Recruiting

Study of the Occurrence of Cardiocirculatory Arrest as a Function of the Level of Hypoxemia During a Maastricht 3 Procedure

NCT06780722Cardiac Arrest, Reanimation

Nantes University Hospital

Observational

Angers, Annecy, Avignon, La Roche-sur-Yon, Lille, Nantes, Orléans, Poitiers

2025-12-19

Recruiting

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

NCT07222800Intestinal Neoplasms, Gastrointestinal Neoplasms, Digestive System Neoplasms, Neoplasms by Site

DrugsPF-08634404·Avastin·Bevacizumab

Pfizer

Phase 3

800

Villejuif, Brest, Dijon, Lille, Paris, Poitiers, Créteil

2025-12-11

Recruiting

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

NCT07007559Breast Cancer, Metastatic

DrugsEvorpacept·Eribulin·Herceptin·Vinorelbine

ALX Oncology Inc.

Phase 2

120

Besançon, Bordeaux, Paris, Poitiers, Rennes

2025-12-10

Recruiting

Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas

NCT06346197Gastric Cancer, MSI-H, Metastatic Cancer, Advanced Cancer

DrugsFOLFOX Protocol·Balstilimab·Botensilimab·Xelox

Centre Leon Berard

Phase 3

132

Brest, Clermont-Ferrand, Lyon, Marseille, Paris, Poitiers

2025-12-08

Not yet open

Impact of Ambulatory Management for Primary Spontaneous Pneumothorax in the Emergency Department on Quality of Life

NCT06471608Primary Spontaneous Pneumothorax, Quality of Life, Ambulatory Care, Chest Tube

University Hospital, Strasbourg, France

Not applicable

386

Besançon, Bordeaux, La Tronche, Paris, Poitiers, Strasbourg

2025-12-01

Recruiting

A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD

NCT06847542Neovascular Age-related Macular Degeneration

DrugRanibizumab

Hoffmann-La Roche

Phase 3

250

Nantes, Lyon, Montauban, Paris, Poitiers, Strasbourg

2025-11-27

Recruiting

Trial Evaluating the Benefit of Left Bundle Branch Area Stimulation Compared With Conventional Pacing in Post-TAVI Atrioventricular Atrioventricular Block

NCT07236489Atrioventricular Block, Pacemaker

Nantes University Hospital

Not applicable

266

Brest, Rennes, Tours, Nantes, Clermont-Ferrand, Rouen, Poitiers

2025-11-25

Recruiting

A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer

NCT06948448Colorectal Cancer

DrugsONO-4578·Leucovorin·Opdivo·Adrucil

Ono Pharmaceutical Co., Ltd.

Phase 2

144

Besançon, Pessac, Nantes, Marseille, Paris, Lyon, Poitiers

2025-11-18

Recruiting

Durvalumab and Tremelimumab With or Without Hepatic Arterial Infusion of Chemotherapy in Hepatocellular Carcinoma

NCT06904170Hepatocellular Carcinoma

DrugsGemox·HAIC·Tremelimumab·Durvalumab

UNICANCER

Phase 2/3

196

Bordeaux, Clichy, Dijon, Marseille, Montpellier, Nantes, Paris, Poitiers

2025-11-14

Recruiting

TOETVA Technique Compared With Anterior Cervical Thyroidectomy (AC) in Terms of Efficacy and Safety

NCT07055191Lobectomy, Thyroidectomy

University Hospital, Lille

Not applicable

616

Bobigny, Levallois-Perret, Lille, Limoges, Nantes, Paris, Pierre-Bénite, Poitiers

2025-11-07

Not yet open

PErioperative CISGEM + Rilvegostomig in High-Risk Resectable Intra Hepatic CholangioCarcinoma

NCT07128290Intrahepatic Cholangiocarcinoma (Icc)

DrugRilvegostomig

Federation Francophone de Cancerologie Digestive

Phase 2

Caen, Dijon, Grenoble, Limoges, Marseille, Nancy, Nantes, Poitiers

2025-10-30

Recruiting

A Non-interventional Study of Participants With BPDCN Treated With Chemotherapy

NCT07785180Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Stemline Therapeutics, Inc.

Observational

140

Besançon, Bobigny, Bordeaux, Créteil, Nice, Paris, Poitiers, Tours

2025-10-17

By invitation

Efficacy and Tolerance of Treatment With Bevacizumab for Severe Liver Involvement With High Cardiac Output in Hereditary Hemorrhagic Telangiectasia Within the French Hereditary Hemorrhagic Telangiectasia Network

NCT07445347Hereditary Hemorrhagic Telangiectasia (HHT), Pulmonary Hypertension, Bevacizumab

DrugBevacizumab

Poitiers University Hospital

Observational

111

Poitiers

2025-10-15

Recruiting

Feasibility Study to Diagnose Helicobacter Pylori in the Paediatric Population Using Non-invasive Fecal Analysis

NCT07083804HELICOBACTER PYLORI INFECTIONS

Poitiers University Hospital

Observational

188

Poitiers

2025-10-07

Recruiting

Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronary Syndromes

NCT07102628Acute Coronary Syndrome

DrugInclisiran

Novartis Pharmaceuticals

Phase 3

300

Chambray-lès-Tours, Montpellier, Nantes, Pessac, Poitiers

2025-10-03

Recruiting

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

NCT06989437Cachexia, Metastatic Pancreatic Ductal Adenocarcinoma

DrugPonsegromab

Pfizer

Phase 2/3

982

Marseille, Créteil, Villejuif, Poitiers

2025-10-03

Not yet open

LIDOCRIT : Effect of Continuous Intravenous LIDOcaine on Discomfort in Postoperative CRITical Care Inpatients

NCT07043023Post-surgery Critical Incare

DrugLidocaine

Rennes University Hospital

Phase 4

246

Angers, Brest, Chartres, Nantes, Poitiers, Rennes, Saint-Nazaire, Tours

2025-10-01

Recruiting

Efficacy of Daily IV Administration of Dornase Alfa up to 14 Days Post Subarachnoid Hemorrhage on Functional Independence at 6 Months

NCT06723717Ruptured Aneurysm of Intracranial Artery, SAH (Subarachnoid Hemorrhage), Delayed Cerebral Ischemia

DrugDornase Alfa

Fondation Ophtalmologique Adolphe de Rothschild

Phase 2

304

Grenoble, Lyon, Montpellier, Poitiers, Strasbourg, Suresnes

2025-09-26

Recruiting

Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Insemination

NCT06804538Infertility, Intrauterine Insemination (IUI)

University Hospital, Toulouse

Not applicable

692

Bordeaux, La Réunion, Poitiers, Toulouse

2025-09-09

Recruiting

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

NCT07181109High Risk Cardiovascular Disease, Hypertension, High Cardiovascular Risk

DrugZilebesiran

Alnylam Pharmaceuticals

Phase 3

11,000

Auxerre, Bobigny, Bordeaux, Caen, Nîmes, Paris, Pau, Poitiers

2025-09-06

Not yet open

Neoadjuvant Pembrolizumab With a Watch-and-wait Strategy for dMMR/MSI-H Localized Colon Cancer: PREMICES Study.

NCT06646445Colon Cancer

DrugsKeytruda·Pembrolizumab

GERCOR - Multidisciplinary Oncology Cooperative Group

Phase 2

Avignon, Besançon, Levallois-Perret, Lyon, Paris, Pessac, Poitiers, Toulouse

2025-09

Recruiting

Sotorasib Combined With First-line Chemotherapy for Advanced Pancreatic Adenocarcinoma

NCT06892054Pancreatic Adenocarcinoma

DrugSotorasib

Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)

Phase 1

Avignon, Besançon, Brest, Lille, Lyon, Pessac, Poitiers, Reims

2025-08-08

Recruiting

Phase 2/3 Study of Participants With Recurrent Pericarditis Evaluating the Efficacy and Safety of KPL-387

NCT07010159Pericarditis, Pericarditis Acute, Recurrent Pericarditis

DrugKPL-387

Kiniksa Pharmaceuticals International, plc

Phase 2/3

325

Montpellier, Paris, Pessac, Poitiers, Toulouse

2025-07-25

Recruiting

Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

NCT06757634Breast Cancer

DrugsGedatolisib·Ribociclib·Palbociclib·Letrozole

Celcuity Inc

Phase 3

1,180

Amiens, Caen, Dijon, Le Mans, Marseille, Pierre-Bénite, Poitiers, Villejuif

2025-07-24

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)

NCT06953960Multiple Myeloma

DrugsEtentamig·Pomalidomide·Daratumumab·Dexamethasone

AbbVie

Phase 1/2

325

Montpellier, Poitiers, Toulouse, Nantes, Paris

2025-07-23

Active, closed

MyocarditIRM-Génétique - Genetic Sub-study of the French Cohort of Acute Myocarditis Cases Diagnosed by MRI

NCT07717073Acute Myocarditis

French Cardiology Society

Observational

602

Poitiers

2025-07-15

Recruiting

Comparison of Two Ventilation Methods During Endoscopy of the Pharynx, Larynx and Oesophagus

NCT07004699Oxygen Inhalation Therapy Endoscopy

Poitiers University Hospital

Not applicable

610

La Roche-sur-Yon, Limoges, Poitiers

2025-07-11

Recruiting

Evaluation of Percutaneous Cryoneurotomy Compared to Surgical Open Neurotomy for the Management of Equinovarus Foot Deformity in Patients With Refractory Lower Limb Spasticity After Stroke

NCT06726434Stroke, Equinovarus Foot, Refractory Lower Limb Spasticity

Poitiers University Hospital

Not applicable

114

Garches, Montpellier, Poitiers, Rennes, Saint-Etienne, Toulouse

2025-07-09

Not yet open

PANORAMIX : Optimizing 1st-line NALIRIFOX and Exploring Microbiota's Role in 2nd Line Pancreatic Cancer Treatment

NCT07028424PDAC - Pancreatic Ductal Adenocarcinoma

DrugsNal-IRI·Ciprofloxacin·Leucovorin·Adrucil

GERCOR - Multidisciplinary Oncology Cooperative Group

Phase 2

206

Besançon, La Tronche, Lille, Paris, Poitiers, Reims, Saint-Cloud, Saint-Etienne

2025-07

Recruiting

Identification of Innovative Biomarkers to Predict Outcomes in Hepatocellular Carcinoma Treated With Tremelimumab and Durvalumab

NCT06796114Hepatocellular Carcinoma

Centre Hospitalier Universitaire de Besancon

Not applicable

120

Besançon, Chalon-sur-Saône, Grenoble, Mulhouse, Paris, Poitiers, Reims, Strasbourg

2025-06-25

Recruiting

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

NCT06846281Relapsing Multiple Sclerosis

DrugsRemibrutinib·Ocrelizumab

Novartis Pharmaceuticals

Phase 3

400

Bordeaux, Clermont-Ferrand, Lille, Marseille, Nice, Nîmes, Paris, Poitiers

2025-06-23

Recruiting

Ventricular Arrhythmias in Acute Myocardial Infarction

NCT07517523Ventricular Arrhythmia, Acute Myocardial Infarction (AMI)

Poitiers University Hospital

Observational

500

Caen, Dijon, Grenoble, Paris, Pau, Poitiers, Saint-Etienne, Tours

2025-06-20

Recruiting

A Phase 2 Study to Assess STP938 (Dencatistat) as a Monotherapy in Adults With High Risk Essential Thrombocythaemia - The VECTRA Trial

NCT06786234Essential Thrombocythaemia

DrugSTP938

Step Pharma, SAS

Phase 2

Poitiers, Brest, Marseille, Nantes, Nice, Nîmes, Paris, Villejuif

2025-06-18

Recruiting

First-in-human Trial of STC-1010, an Immunotherapy, in Patients With Unresectable Locally Advanced or Metastatic Colorectal Cancer

NCT06934538Unresectable Metastatic Colorectal Cancer, Unresectable Locally Advanced Colorectal Cancer

Brenus Pharma

Phase 1/2

Bordeaux, Dijon, Lyon, Montpellier, Poitiers, Villejuif

2025-06-17

Recruiting

A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)

NCT06885034Gastrointestinal Neoplasms

DrugRisvutatug rezetecan

GlaxoSmithKline

Phase 1/2

346

Dijon, Marseille, Paris, Poitiers, Rennes, Villejuif

2025-06-11

Recruiting

A Study of Momelotinib in Participants With Low-risk Myelodysplastic Syndrome

NCT06847867Myelodysplastic Syndromes

DrugMomelotinib

GlaxoSmithKline

Phase 2

Le Mans, Nice, Paris, Poitiers, Toulouse

2025-06-05

Recruiting

A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS)

NCT06782373VEXAS, VEXAS Syndrome

DrugPacritinib

Swedish Orphan Biovitrum

Phase 2

156

Lille, Paris, Pierre-Bénite, Poitiers, Toulouse

2025-05-28

Recruiting

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

NCT06499285Myelodysplastic Syndromes

DrugElritercept

Takeda

Phase 3

225

Nice, Paris, Poitiers, Toulouse

2025-05-06

Active, closed

Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

NCT06813911Atherosclerotic Cardiovascular Disease (ASCVD)

DrugsPelacarsen·Inclisiran

Novartis Pharmaceuticals

Phase 3

246

Béziers, Cholet, Grenoble, Lille, Montpellier, Paris, Pessac, Poitiers

2025-04-30

Recruiting

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

NCT06820463Metastatic Colorectal Cancer

DrugsTelisotuzumab Adizutecan·Panitumumab·Fluorouracil·Leucovorin

AbbVie

Phase 2

390

Lille, Poitiers, Nantes, Paris

2025-04-24

Recruiting

Impact of an Early Warning System on the Prognosis of Patients With Hematological Malignancies Receiving Intensive Chemotherapy With or Without Hematopoietic Cell Transplantation.

NCT06409767Leukemia, Lymphoma, Multiple Myeloma

University Hospital, Angers

Not applicable

2,224

Amiens, Angers, Besançon, Brest, Nancy, Nantes, Poitiers, Saint-Etienne

2025-04-10

Recruiting

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

NCT06790693Breast Cancer

DrugsCDK4/6i·Inavolisib·Letrozole

Hoffmann-La Roche

Phase 3

450

Angers, Lille, Montpellier, Paris, Plérin, Poitiers, Rennes, Rouen

2025-04-09

Recruiting

Comparison of the Effectiveness of Ultrasound-guided Techniques and Infrared Illumination, Compared With the Standard Approach to Peripheral Venous Line Placement in People With Difficult Venous Access

NCT06838364Peripheral Venous Catheterization

Poitiers University Hospital

Not applicable

264

Poitiers

2025-04-08

Not yet open

Financial Incentives and Weight Loss in Failed Bariatric Surgery

NCT06910735Obesity, Obesity Recidivism

Assistance Publique - Hôpitaux de Paris

Not applicable

264

Bobigny, Colombes, Créteil, Marseille, Nantes, Orléans, Paris, Poitiers

2025-04

Recruiting

A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.

NCT06898450Advanced Solid Tumors Cancer, MSI-H Cancer

Nimbus Wadjet, Inc.

Phase 1/2

134

Paris, Poitiers

2025-03-31

Recruiting

Efficacy of Pemigatinib in Patients With Solid Tumors Characterized by an Alteration of the Gene FGFR in Tumor Cells

NCT06653777Solid Tumor, Miscellaneous

DrugPemigatinib

UNICANCER

Phase 2

Brest, Nice, Paris, Poitiers, Saint-Priest-en-Jarez, Vandœuvre-lès-Nancy

2025-03-27

Recruiting

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

NCT06890598Carcinoma, Non-Small-Cell Lung

DrugsOlomorasib·Durvalumab·Pembrolizumab

Eli Lilly and Company

Phase 3

700

Bron, La Tronche, Lyon Cedex08, Marseille, Nice, Paris, Pessac, Poitiers

2025-03-27

Active, closed

The Effect of Hedia Diabetes Assistant on TiMe-in-range in People With Type 1 Diabetes and Sub-Optimal Glycemic Control in France - A Randomised Controlled Trial.

NCT06819306Type 1 Diabetes Mellitus (T1DM)

Hedia ApS

Not applicable

154

Angers, Lyon, Nantes, Nîmes, Paris, Poitiers

2025-03-17

Active, closed

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

NCT06792695Metastatic Colorectal Cancer

DrugsFOLFIRI (Fluorouracil (5-FU), leucovorin, irinotecan)·Volrustomig·Bevacizumab

AstraZeneca

Phase 2

Montpellier, Poitiers, Saint-Priez En Jarez, Villejuif

2025-03-12

Recruiting

An Open-label Study to Evaluate the Pharmacokinetics and Safety of Bimekizumab in Pediatric Study Participants With Active Juvenile Idiopathic Arthritis Subtypes Enthesitis-related Arthritis (Including Juvenile-onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis

NCT06668181Enthesitis-related Arthritis, Juvenile Psoriatic Arthritis

DrugBimekizumab

UCB Biopharma SRL

Phase 3

Indre-et-Loire, Le Kremlin-Bicêtre, Paris, Poitiers

2025-03-11

Recruiting

Bevacizumab-based Chemotherapy Adapted to Bevacizumab Pharmacokinetics in 1st-line Treatment

NCT06642844Unresectable Metastatic Colorectal Cancer

DrugAvastin

University Hospital, Tours

Phase 3

244

Besançon, Clermont-Ferrand, Gustave Roussy, Poitiers

2025-03-04

Recruiting

A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

NCT06764875HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma

DrugsRilvegostomig·Trastuzumab deruxtecan·Trastuzumab·Adrucil

AstraZeneca

Phase 3

840

Bordeaux, Caen, Clermont-Ferrand, Dijon, Lyon, Marseille, Poitiers, Rennes

2025-03-01

Recruiting

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis

NCT06517875Primary Myelofibrosis, Myelofibrosis; Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis

DrugsMomelotinib·Reblozyl·Luspatercept

GlaxoSmithKline

Phase 2

Angers, Brest, Lyon, Nice, Nîmes, Paris, Poitiers

2025-02-28

Recruiting

Effect of Acute Hypoxia on Renal Hemodynamic in Healthy Volunteers, Patients With Diabetes and Patients With Diabetes and Kidney Disease

NCT06846034Diabetes, Diabetic Kidney Disease, Hypoxia, Healthy Volunteer

Poitiers University Hospital

Not applicable

Poitiers

2025-02-13

Recruiting

Prospective Multicenter Study of the Relationship Between Virological Effectiveness and Compliance in HIV-1-infected Patients Treated With Bictegravir

NCT06902142HIV Antiretroviral Therapy (ART) Adherence

Association pour la promotion de la recherche en maladies infectieuses et tropicales dans le Loiret

Observational

120

Caen, La Roche-sur-Yon, Lyon, Nantes, Niort, Orléans, Paris, Poitiers

2025-02-11

Active, closed

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

NCT06834360Chronic Rhinosinusitis With Nasal Polyps

DrugsItepekimab·Mometasone furoate

Sanofi

Phase 3

216

Bordeaux, Marseille, Nantes, Poitiers, Pontoise, Toulouse

2025-02-06

Recruiting

Impact of Pain From Injectables Antiretroviral Treatments in HIV-1 Patients Based on the Injection Site (Ventrogluteal or Dorsogluteal) and the Use or Non-use of Virtual Reality Headset

NCT06834113HIV I Infection, Injection Pain

Centre Hospitalier Régional d'Orléans

Not applicable

120

Orléans, La Roche-sur-Yon, Le Coudray, Nantes, Poitiers

2025-01-24

Recruiting

Effects of Endocrine Disruptors on the Gut Microbiota and Assessment of Their Impact on Colorectal Cancer Development (PERMICA)

NCT06809660Colorectal Cancer (CRC), Endocrine Disruptors, Microbiota, Dysbiosis

Poitiers University Hospital

Not applicable

200

Poitiers

2025-01-21

Recruiting

Self-Dehumanization and Hesitation to Report Domestic Violence

NCT07015502Domestic Violence

Centre Hospitalier Henri Laborit

Observational

Poitiers

2024-12-20

Active, closed

Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

NCT06608927Metastatic Pancreatic Ductal Adenocarcinoma

DrugsQuemliclustat·Nab-paclitaxel·Gemcitabine

Arcus Biosciences, Inc.

Phase 3

610

Dijon, Lille, Lyon, Poitiers, Villejuif

2024-12-13

Recruiting

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

NCT06750094Colorectal Neoplasms

DrugsLeucovorin calcium/Levoleucovorin·Amivantamab·Erbitux·Avastin

Janssen Research & Development, LLC

Phase 3

700

Avignon, Pessac, Poitiers

2024-12-12

Recruiting

Albumin Modifications as Early Biomarkers of Chronic Liver Diseases

NCT06318949Chronic Liver Disease

University Hospital, Limoges

Not applicable

756

Angers, Limoges, Poitiers, Rennes, Toulouse, Tours

2024-12-09

Active, closed

A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab

NCT06706817Chronic Rhinosinusitis With Nasal Polyps

AstraZeneca

Phase 3

181

Le Kremlin-Bicêtre, Marseille, Nantes, Pierre-Bénite, Poitiers, Toulouse

2024-12-03

Recruiting

A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

NCT06541704Age-related Macular Degeneration (AMD), Geographic Atrophy (GA)

DrugsCemdisiran·Pozelimab

Regeneron Pharmaceuticals

Phase 3

975

Nice, Marseille, Poitiers, Toulouse, Créteil, Dijon, Lille, Lyon

2024-10-30

Recruiting

A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)

NCT06649110Healthy Volunteers, Pulmonary Arterial Hypertension

Novartis Pharmaceuticals

Phase 1/2

232

Angers, Brest, Clamart, Grenoble, Montpellier, Nice, Pessac, Poitiers

2024-10-24

Recruiting

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

NCT06662786Colorectal Neoplasms

DrugsLeucovorin calcium/Levoleucovorin·Amivantamab·Erbitux·Irinotecan

Janssen Research & Development, LLC

Phase 3

1,000

Avignon, Lille, Lyon, Montpellier, Nantes, Paris, Pessac, Poitiers

2024-10-18

Recruiting

Study to Evaluate Music Therapy on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD)

NCT06414967Huntington Disease

Poitiers University Hospital

Not applicable

Poitiers

2024-10-15

Recruiting

Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations

NCT06581432Solid Tumours

DrugZongertinib

Boehringer Ingelheim

Phase 2

588

Bordeaux, Dijon, Lyon, Marseille, Poitiers, Villejuif

2024-10-11

Active, closed

A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy

NCT06481891Obstructive Cardiomyopathy, Hypertrophic, Non-obstructive Hypertrophic Cardiomyopathy

DrugSotagliflozin

Lexicon Pharmaceuticals

Phase 3

500

Chambray-lès-Tours, Marseille, Paris, Poitiers, Rennes, Toulouse

2024-09-24

Active, closed

A Trial to Learn if Fianlimab and Cemiplimab Are Safe and Work Better Than Anti-PD1 Alone in Adult Participants With Resectable Stage 3 or 4 Melanoma

NCT06190951Melanoma

DrugsFianlimab·Cemiplimab

Regeneron Pharmaceuticals

Phase 2

151

Pierre-Bénite, Dijon, Tours, Bordeaux, La Tronche, Poitiers, Caen, Nantes

2024-09-18

Recruiting

A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma

NCT06140524Monoclonal Gammopathy of Undetermined Significance (MGUS), Smoldering Multiple Myeloma (SMM)

DrugLinvoseltamab

Regeneron Pharmaceuticals

Phase 2

116

Poitiers, Paris

2024-09-16

Active, closed

Efficacy and Safety of Gemlapodect (NOE-105) in Adults and Adolescents With Tourette Syndrome

NCT06315751Tourette Syndrome

Noema Pharma AG

Phase 2

164

Bron, Poitiers

2024-09-10

Recruiting

Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)

NCT06274801Pulmonary Arterial Hypertension

Gossamer Bio USA, Inc.

Phase 3

330

Le Kremlin-Bicêtre, Lille, Nice, Poitiers

2024-09-03

Active, closed

A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma

NCT06425302Lymphoma, Follicular

DrugsEndoxan·Golcadomide·Pegylated liposomal doxorubicin·Bendamustine

Celgene

Phase 2

Saint-Cloud, Lille, Poitiers, Paris

2024-08-30

Active, closed

A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma

NCT06413498Multiple Myeloma

DrugsAnitocabtagene Autoleucel·Carfilzomib·Pomalidomide·Bortezomib

Kite, A Gilead Company

Phase 3

452

Lille, Marseille, Montpellier, Nantes, Paris, Pierre-Bénite, Poitiers, Rennes

2024-08-23

Active, closed

A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

NCT06508658Diffuse Large B-Cell Lymphoma

DrugsEpcoritamab·Lenalidomide·Rituximab·Oxaliplatin

Genmab

Phase 3

379

Strasbourg, Caen, Tours, Avignon, Bayonne, Poitiers, Lille

2024-08-13

Recruiting

Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure

NCT06427304Cardiac Amyloidosis

Gérond'if

Observational

637

Paris, Nantes, Poitiers, Rouen, Montpellier, Toulouse, Amiens, Angers

2024-07-01

Recruiting

Severe Complications During Ventricular Tachycardia or Premature Ventricular Complex Ablation

NCT07777744Ventricular Tachycardia (VT), Premature Ventricular Complexes

University Hospital, Basel, Switzerland

Observational

15,000

Bordeaux, Chambray-lès-Tours, Poitiers, Toulouse

2024-07-01

Active, closed

A Phase III Study to Investigate the Efficacy and Safety of Anifrolumab in Adults With Chronic and/or Subacute Cutaneous Lupus Erythematosus

NCT06015737Cutaneous Lupus Erythematosus

AstraZeneca

Phase 3

339

Bois-Guillaume, Dijon, Lyon, Montivilliers, Nantes, Paris, Poitiers, Toulouse

2024-06-29

Active, closed

Assessment of HGI (Hemoglobin Glycation Index) Variability Over Time in Patients Living With Diabetes Using Continuous Glucose Monitoring ( GAP OUEST )

NCT06185491Diabetes Mellitus

Nantes University Hospital

Not applicable

750

Angers, Brest, Caen, Le Mans, Nantes, Poitiers, Pontoise, Rennes

2024-06-24

Active, closed

ELVN-002 With Trastuzumab +/- Chemotherapy in HER2+ Solid Tumors, Colorectal and Breast Cancer

NCT06328738HER2-positive Breast Cancer, HER2-positive Gastric Cancer, HER2 Positive Solid Tumors, HER2 Amplification

DrugsELVN-002·Eribulin·Leucovorin·Trastuzumab

Enliven Therapeutics

Phase 1

275

Montpellier, Poitiers, Saint-Herblain, Strasbourg

2024-05-30

Recruiting

Superiority Trial Evaluating Digitalized Information Media for Patients With Advanced Sarcomas Receiving Systemic Treatment.

NCT06211257Sarcoma Metastatic, Locally Advanced Soft Tissue Sarcoma

Centre Oscar Lambret

Not applicable

377

Lyon, Besançon, Rennes, Strasbourg, Lille, Poitiers, Toulouse, Saint-Herblain

2024-05-29

Active, closed

Use of Elranatamab in Patients With High-risk Smoldering Multiple Myeloma

NCT06183489Smoldering Multiple Myeloma

DrugElranatamab

European Myeloma Network B.V.

Phase 2

La Roche-sur-Yon, Montpellier, Nantes, Poitiers, Tours

2024-05-14

Active, closed

A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015)

NCT06356311Gastroesophageal Cancer

DrugsTrifluridine/Tipiracil·Sacituzumab tirumotecan·Irinotecan·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

473

Bordeaux, Lyon, Caen, Toulouse, Lille, Rennes, Poitiers, Paris

2024-05-03

By invitation

Long-term Risk of Second Primary Malignancies for Chronic Myeloid Leukaemia in the French Imatinib-based SPIRIT Trial

NCT06646978Chronic Myeloid Leukemia (CML)

DrugImatinib

Poitiers University Hospital

Observational

787

Poitiers

2024-05-01

Recruiting

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

NCT06312176Breast Neoplasms

DrugsLiposomal doxorubicin·Abraxane·Xeloda·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

1,200

Lyon, Caen, Montpellier, Nantes, Poitiers, Paris

2024-04-14

Recruiting

Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.

NCT06119516ARDS, Human, Obesity, Morbid

Assistance Publique - Hôpitaux de Paris

Not applicable

Angers, Le Kremlin-Bicêtre, Lyon, Paris, Poitiers

2024-04-04

Recruiting

Influence of Control Deprivation on the Use of the Analytical Cognitive Style in Anorexic Subjects

NCT07274722Anorexia Nervosa

Centre Hospitalier Henri Laborit

Not applicable

Poitiers

2024-04-04

Active, closed

A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation

NCT06200207Heart Failure, Systemic Inflammation

DrugZiltivekimab

Novo Nordisk A/S

Phase 3

673

Chambray-lès-Tours, Poitiers, Rennes, Rouen, Toulon, Valenciennes, Vandœuvre-lès-Nancy

2024-04-01

Recruiting

A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors

NCT06265727Solid Tumor, Adult

DrugsCRB-701·Anti-PD-1

Corbus Pharmaceuticals Inc.

Phase 1/2

348

Montpellier, Poitiers, Saint-Herblain, Villejuif

2024-04-01

Not yet open

Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO)

NCT06349798Total Hip Arthroplasty

DrugsNefopam·NaCl

University Hospital, Tours

Phase 3

546

Angers, Blois, Chartres, Nantes, Orléans, Poitiers, Tours

2024-04

Recruiting

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

NCT06256588Neoplasms, Head and Neck

DrugDostarlimab

GlaxoSmithKline

Phase 3

864

Ars-Laquenexy, Caen, Dijon, Marseille, Poitiers, Quimper, Rennes, Rouen

2024-03-21

Recruiting

A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

NCT05646381Aortic Stenosis

DrugPelacarsen

Novartis Pharmaceuticals

Phase 2

502

Paris, Pessac, Poitiers, Rennes

2024-03-07

By invitation

Impact of Respiratory Allergy on Response to Initiation of Biotherapy in Severe Asthma in Adult Severe Asthmatic Patients Followed at Poitiers University Hospital on Biotherapy

NCT06916104Severe Asthma, Biotherapy, Respiratory Allergy

Poitiers University Hospital

Observational

100

Poitiers

2024-03-01

Active, closed

Study to Assess Neoadjuvant Durvalumab (D) and Platinum-Based Chemotherapy (CT), Followed by Either Surgery and Adjuvant D or CRT and Consolidation D, in Resectable or Borderline Resectable Stage IIB-IIIB NSCLC (MDT-BRIDGE)

NCT05925530Non-small Cell Lung Cancer

DrugDurvalumab

AstraZeneca

Phase 2

142

La Tronche, Marseille, Montpellier, Mulhouse, Paris, Pessac, Poitiers, Toulouse

2024-02-22

Recruiting

Early High-flow Oxygen Therapy With nebuLized Beta-2-agonist Using a Vibrating Mesh for the Management of Moderate to Severe Asthma Exacerbation in the Emergency Department

NCT05691218Moderate Asthma Exacerbation, Severe Asthma Exacerbation

Poitiers University Hospital

Not applicable

Poitiers

2024-02-19

Recruiting

Treatment of Upper Limb Chronic Neuropathic Pain by Electrical Stimulation of the Brachial Plexus Nerve Roots

NCT05817786Neuralgia

Centre Hospitalier Universitaire de Nice

Not applicable

Lyon, Nice, Poitiers

2024-02-09

Active, closed

Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)

NCT05853575Advanced Cancer, Metastatic Cancer, Malignant Neoplasm of Lung

DrugAdagrasib

Mirati Therapeutics Inc.

Phase 2

200

Grenoble, Pessac, Saint-Herblain, Angers, Lorient, Nantes, Poitiers, Nice

2024-02-01

Recruiting

Intense Pulsed Light (IPL) Medical Device as Treatment for Patient Suffering From Skin Disorder

NCT06655129Excessive Hairiness, Vascular Lesion, Pigmented Lesions, Acne Vulgaris

Eurofeedback

Not applicable

Auxerre, Brest, Nice, Périgueux, Poitiers

2024-01-20

Active, closed

Study of ALXN2220 Versus Placebo in Adults With ATTR-CM

NCT06183931Transthyretin Amyloid Cardiomyopathy

DrugCliramitug

Alexion Pharmaceuticals, Inc.

Phase 3

1,182

Bron, Chambray-lès-Tours, Créteil, Marseille, Montpellier, Paris, Pessac, Poitiers

2024-01-11

Recruiting

ctDNA in CRC Patients Undergoing Curative-intent Surgery for Liver Metastases

NCT05787197Metastatic Colorectal Cancer, Circulating Tumor DNA

GERCOR - Multidisciplinary Oncology Cooperative Group

Observational

232

Besançon, Bordeaux, Lille, Lyon, Paris, Pessac, Poitiers, Rouen

2024-01-09

Active, closed

Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa

NCT06079281Hypophosphatasia

DrugALXN1850

Alexion Pharmaceuticals, Inc.

Phase 3

124

Paris, Poitiers

2024-01-03

Recruiting

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

NCT06119581Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

DrugsOlomorasib·Pemetrexed·Cisplatin·Carboplatin

Eli Lilly and Company

Phase 3

1,264

Avignon, Bron, Lille, Lyon Cedex08, Nice, Paris, Pessac, Poitiers

2023-12-21

Recruiting

Global Trial in APG2575 for Patients With CLL/SLL

NCT06104566CLL/SLL

DrugLisaftoclax

Ascentage Pharma Group Inc.

Phase 3

400

Clermont-Ferrand, Le Mans, Lyon, Nantes, Nîmes, Orléans, Poitiers, Pontoise

2023-12-20

Recruiting

Observational Study Protocol: LIVER-R

NCT06252753Hepatobiliary Cancers

AstraZeneca

Observational

4,000

Strasbourg, Grenoble, St-Malo, Mulhouse, Boulogne-sur-Mer, Poitiers, Avignon, Marseille

2023-12-20

Recruiting

A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment

NCT05828511Multiple Myeloma

DrugLinvoseltamab

Regeneron Pharmaceuticals

Phase 1/2

149

Poitiers, Lille, Montpellier, Paris, Antony, Villejuif

2023-12-19

Recruiting

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

NCT06170788Non-small Cell Lung Cancer (NSCLC)

DrugsSacituzumab tirumotecan·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

614

Marseille, Montpellier, Limoges, Nancy, Bayonne, Villefranche-sur-Saône, Amiens, Poitiers

2023-12-15

Recruiting

A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma

NCT06091865Diffuse Large B-cell Lymphoma (DLBCL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Cytoxan

Regeneron Pharmaceuticals

Phase 3

904

Quimper, Rennes, Tours, Bordeaux, Pessac, Poitiers, Lille, Nantes

2023-12-13

Recruiting

A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma

NCT06091254Follicular Lymphoma (FL)

DrugsOdronextamab·Prednisone/Prednisolone·Adriamycin·Bendamustine

Regeneron Pharmaceuticals

Phase 3

822

Rennes, Tours, Nantes, Marseille, Poitiers, Angers, Paris, Strasbourg

2023-12-12

Active, closed

A Study to Evaluate the Efficacy and Safety of Ropeginterferon Alfa-2b in Essential Thrombocythaemia Patients

NCT06514807Essential Thrombocythaemia

DrugBesremi

AOP Orphan Pharmaceuticals AG

Phase 3

117

Poitiers, Paris, Pessac

2023-12-04

Recruiting

A Study to Evaluate Pre-operative HYPOfractionated Radiation Therapy in Aged (≥ 70 Years Old) or "Fragile" (≥ 65 Years) Patients With Limb or Trunk Soft Tissue SARComa.

NCT06022159Soft Tissue Sarcoma

Institut Claudius Regaud

Phase 2

Bordeaux, Lille, Limoges, Lyon, Montpellier, Paris, Poitiers, Saint-Herblain

2023-11-28

Recruiting

Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma (TRIgnite-1)

NCT05862012Relapsed/Refractory Multiple Myeloma

Ichnos Sciences SA

Phase 1

200

Lille, Poitiers, Nantes, Paris

2023-11-01

Recruiting

Effects of Transcranial Direct Current Stimulation (tDCS) in the Management of Suicidal Ideation

NCT06009523Depression and Suicide

Centre Hospitalier Henri Laborit

Not applicable

Faye-l'Abbesse, Poitiers

2023-10-26

Active, closed

Multicenter Phase 2 Study of Subcutaneous Isatuximab Plus Bortezomib, Lenalidomide and Dexamethasone in the Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma

NCT05889221Multiple Myeloma, Myeloma Multiple, Myeloma

Poitiers University Hospital

Not applicable

Poitiers

2023-10-23

Recruiting

tDCS Associated With Symptom Provocation in the Management of Patients With Resistant Obsessive Compulsive Disorder

NCT06017713Obsessive-Compulsive Disorder

Centre Hospitalier Henri Laborit

Not applicable

Poitiers

2023-10-17

Active, closed

A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation

NCT06045806Multiple Myeloma

DrugsIdecabtagene vicleucel·Endoxan·Fludara·Cytoxan

Celgene

Phase 3

Pessac, Marseille, Lille, Nantes, Pierre-Bénite, Créteil, Villejuif, Poitiers

2023-10-16

Active, closed

A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma

NCT05257083Multiple Myeloma

DrugsCilta-cel·Bortezomib·Daratumumab·Lenalidomide

Stichting European Myeloma Network

Phase 3

759

Lille, Lyon, Nantes, Poitiers, Saint-Louis, Toulouse

2023-10-10

Recruiting

Interventions to Remedy the Negative Effects of Obesity Stigma

NCT05906238Obesity, Stigma, Weight

Poitiers University Hospital

Not applicable

210

Poitiers

2023-10-10

Active, closed

A Study to Assess Luspatercept in Lower-risk Myelodysplastic Syndrome Participants

NCT06045689Myelodysplastic Syndromes

DrugsReblozyl·Luspatercept

Bristol-Myers Squibb

Phase 3

106

Nice, Poitiers, Angers, Grenoble, Paris, Pierre-Bénite, Tour Cedex01

2023-10-05

Active, closed

New Imaging Biomarkers Predictive of MA Progression

NCT05939362Alzheimer Disease, Magnetic Resonance Spectroscopy, Ultra High Field 7T, Progression of Disease

Poitiers University Hospital

Not applicable

Poitiers

2023-10-02

Recruiting

A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis

NCT06016842Primary Biliary Cholangitis (PBC)

DrugElafibranor

Ipsen

Phase 3

276

Clichy, Créteil, Lille, Lyon, Marseille, Nice, Paris, Poitiers

2023-08-31

Recruiting

A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ ALL (POLARIS-1)

NCT06051409Ph+ ALL, Leukemia, Lymphoblastic, Acute, Philadelphia-Positive

DrugOlverembatinib

Ascentage Pharma Group Inc.

Phase 3

350

Le Chesnay, Lyon, Nantes, Nice, Pessac, Pierre-Bénite, Poitiers, Toulouse

2023-08-31

Active, closed

Pilot Study on the Feasibility of Using Smartphone Data as a Diagnostic Marker for Alzheimer's Disease

NCT05709210Alzheimer Disease, Memory Disorders

Poitiers University Hospital

Not applicable

Poitiers

2023-07-20

Active, closed

Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors

NCT05945823Locally Advanced Unresectable or Metastatic Solid Tumors Including Esophageal Cancer, Esophageal Adenocarcinoma, Esophageal Squamous Cell Cancer, Siewert Type 1 GEJ Cancer

DrugsFutibatinib·Platinol·Leucovorin·Irinotecan

Taiho Oncology, Inc.

Phase 2

Lille, Poitiers

2023-07-13

Recruiting

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

NCT05843604OCD

Centre Hospitalier Henri Laborit

Observational

100

Poitiers

2023-07-03

Recruiting

Detection of Eating Disorders in Pregnant Women

NCT05885971Eating Disorders, Pregnancy Related

Centre Hospitalier Henri Laborit

Not applicable

Poitiers

2023-06-30

Recruiting

Effects of Mindfulness Meditation in Virtual Reality on Craving and Smoking Cessation

NCT05766553Tobacco Use Disorder

Centre Hospitalier Henri Laborit

Not applicable

200

Iteuil, Poitiers

2023-06-15

Recruiting

Identification of Factors Associated With Treatment Response in Patients With Polycythemia Vera, Essential Thrombocythemia, and Pre-myelofibrosis.

NCT05440838Myeloproliferative Neoplasm

University Hospital, Angers

Observational

120

Angers, Brest, Nantes, Poitiers, Rennes, Tours

2023-05-17

Active, closed

An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma

NCT05876754Cholangiocarcinoma

DrugIvosidenib

Servier Affaires Médicales

Phase 3

299

Lyon, Marseille, Montpellier, Nantes, Paris, Pessac, Poitiers

2023-05-03

Recruiting

Evaluation of Membrane Phospholipid and Energy Metabolism in Subjects at High Risk of Psychotic Transition

NCT05865652Patients With Ultra High Risk of Psychotic Transition

Centre Hospitalier Henri Laborit

Not applicable

Poitiers

2023-05-02

Recruiting

Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

NCT05850689Major Depressive Disorder

DrugLumateperone

Intra-Cellular Therapies, Inc.

Phase 3

470

Douai, Nantes, Nîmes, Paris, Poitiers

2023-05-02

Recruiting

MRI Biomarkers Predictive of Disability Progression in Patients With Multiple Sclerosis

NCT05491031Multiple Sclerosis, Magnetic Resonance Spectroscopy

Poitiers University Hospital

Not applicable

Poitiers

2023-04-25

Recruiting

EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment

NCT05790707Mild Cognitive Impairment, Persistent Atrial Fibrillation

Poitiers University Hospital

Not applicable

120

Angers, Brest, Caen, Dijon, Grenoble, Marseille, Poitiers, Saint-Denis

2023-04-21

Recruiting

Biomarkers of Sleep-wake Cycle in Prodromal Alzheimer's Disease: Role in Cognitive Decline?

NCT05629871Neuropathology

University Hospital, Montpellier

Not applicable

132

Montpellier, Poitiers, Toulouse

2023-04-17

Recruiting

Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO)

NCT05596539Hypophosphatasia

Assistance Publique - Hôpitaux de Paris

Observational

200

Bordeaux, Lille, Lyon, Nice, Paris, Poitiers, Rennes, Saint-Priest-en-Jarez

2023-03-22

Recruiting

A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma

NCT05650632Multiple Myeloma

DrugEtentamig

AbbVie

Phase 1

210

Marseille, Créteil, Nantes, Pierre-Bénite, Poitiers, Paris

2023-03-21

Active, closed

Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD

NCT05612035Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease

Merck Sharp & Dohme LLC

Phase 2

129

Marseille, Vandœuvre-lès-Nancy, Angers, Le Kremlin-Bicêtre, Poitiers

2023-03-16

Active, closed

A Study to Learn About a New Medicine Called Vepdegestrant (ARV-471, PF-07850327) in People Who Have Advanced Metastatic Breast Cancer

NCT05654623Advanced Breast Cancer

DrugsVepdegestrant·Fulvestrant

Pfizer

Phase 3

624

Dijon, Montpellier, Saint-Herblain, Angers, Clermont-Ferrand, Avignon, Poitiers, Créteil

2023-03-03

Active, closed

Efficacy and Safety of ATX01 in Adult Patients With CIPN (Chemotherapy-induced Peripheral Neuropathy)

NCT05593614Chemotherapy-induced Peripheral Neuropathy

AlgoTherapeutix

Phase 2

276

Bayonne, Bordeaux, Montpellier, Paris, Poitiers, Reims, Strasbourg, Suresnes

2023-02-28

Recruiting

A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

NCT05651932Multiple Myeloma, Myeloma, Myeloma Multiple

DrugsMezigdomide·Carfilzomib·Pomalidomide·Dexamethasone

K36 Therapeutics, Inc.

Phase 1

165

Villeneuve-d'Ascq, Nantes, Poitiers, Toulouse

2023-02-22

Active, closed

Study of ONCOFID-P-B (PACLITAXEL-HYALURONIC ACID)

NCT05024773Bladder Carcinoma in Situ (CIS)

Fidia Farmaceutici s.p.a.

Phase 3

130

Bordeaux, Clermont-Ferrand, Lille, Marseille, Paris, Poitiers

2022-12-29

Recruiting

COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 Diabetes

NCT05633810Diabete Type 2, Cardiovascular Diseases

DrugsColchicine·Aspirin

Montreal Heart Institute

Phase 3

10,000

Luc-la-Primaube, Vannes, Bezouce, Vergèze, Pins-Justaret, Pornic, Poitiers, Montpellier

2022-12-21

Recruiting

Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Students

NCT05589220Smoking Cessation

DrugNicotine replacement

Poitiers University Hospital

Not applicable

120

Poitiers

2022-12-13

Active, closed

Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1)

NCT05501886Breast Cancer

DrugsGedatolisib·Alpelisib·Palbociclib·Fulvestrant

Celcuity Inc

Phase 3

701

Bordeaux, Caen, La Roche-sur-Yon, Marseille, Poitiers, Strasbourg, Villejuif

2022-12-08

Recruiting

Evaluation of the Effectiveness of the Parkinson Specialized Teams Intervention

NCT05433441Parkinson Disease

University Hospital, Bordeaux

Not applicable

250

Bordeaux, Lille, Limoges, Poitiers

2022-12-06

Recruiting

Nursing Care of Bipolar Patients With Sleeping Disorders Using Luminotherapy and /or Psychoeducation Program (BIPLUMINO)

NCT04917419Bipolar Disorder

Centre Hospitalier Henri Laborit

Not applicable

170

Poitiers

2022-12-05

Active, closed

A Study of Botensilimab and Balstilimab for the Treatment of Colorectal Cancer

NCT05608044Metastatic Colorectal Cancer

DrugsBalstilimab·Botensilimab

Agenus Inc.

Phase 2

234

Besançon, Marseille, Paris, Poitiers, Villejuif

2022-11-30

Recruiting

Pilot Study of the Osteo-Fluidic-Sensitive (OFS) in Tension-type Headache.

NCT05229224Tension-Type Headache Episodic

Poitiers University Hospital

Not applicable

Poitiers

2022-11-29

Active, closed

A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)

NCT05629585Breast Cancer

DrugsDato-DXd·Xeloda·Durvalumab·Keytruda

AstraZeneca

Phase 3

1,174

Angers, Bordeaux, Dijon, Lyon, Montpellier, Nîmes, Paris, Poitiers

2022-11-28

Recruiting

A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and Lenalidomide Compared With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant

NCT05623020Multiple Myeloma

DrugsElranatamab·Bortezomib·Daratumumab·Lenalidomide

Pfizer

Phase 3

1,060

Nice, Toulouse, Poitiers, Nantes, Paris, Tours, Villejuif

2022-11-10

Active, closed

An Observational Study to Assess the Effectiveness and Safety of a Cemiplimab in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) in Routine Clinical Practice Settings in Europe

NCT05363319Non-small Cell Lung Cancer

DrugCemiplimab

Regeneron Pharmaceuticals

Observational

509

Mulhouse, Strasbourg, Marseille, Avignon, Poitiers, Angers, Clermont-Ferrand, Le Mans

2022-10-26

Recruiting

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

NCT05552222Multiple Myeloma

DrugsTalquetamab·Teclistamab·Daratumumab·Lenalidomide

Janssen Research & Development, LLC

Phase 3

1,590

Créteil, Lille, Lyon, Nantes, Paris, Pessac, Poitiers, Rennes

2022-10-25

Active, closed

A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma

NCT05535244Multiple Myeloma

DrugsCevostamab·Tocilizumab

Hoffmann-La Roche

Phase 1/2

Nantes, Paris, Poitiers

2022-10-17

Recruiting

Impact of Virtual Reality in Hematology and Oncology During Invasive Procedures in Children, Adolescents and Young Adults, from 7 to Less Than 25 Years Old

NCT05275881Virtual Reality, Pediatrics, Cancer, Pain

Poitiers University Hospital

Not applicable

Poitiers

2022-10-13

Recruiting

Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

NCT05243797Multiple Myeloma

DrugsTeclistamab·Lenalidomide

European Myeloma Network B.V.

Phase 3

1,594

Bordeaux, Lille, Marseille, Montpellier, Nantes, Paris, Poitiers, Toulouse

2022-09-08

Recruiting

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

NCT05386108Breast Neoplasms, Brain Neoplasms, Neoplasms by Site, Neoplasms

DrugsElacestrant·Abemaciclib

Stemline Therapeutics, Inc.

Phase 1/2

Angers, Brest, Caen, Clermont-Ferrand, Lyon, Montpellier, Paris, Poitiers

2022-08-31

Recruiting

A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments

NCT05137054Multiple Myeloma

DrugsNirogacestat·Cevostamab·Fianlimab·Linvoseltamab

Regeneron Pharmaceuticals

Phase 1

317

Poitiers, Lille, Nantes, Angers, Montpellier, Paris, Villejuif, Créteil

2022-08-17

Recruiting

Cytokine Expression in Psoriasis Patients With and Without Joint Involvement

NCT05307809Psoriasis, Psoriatic Arthritis

Poitiers University Hospital

Not applicable

Poitiers

2022-08-17

Recruiting

A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

NCT05489705Obstructive Hypertrophic Cardiomyopathy

DrugMavacamten

Bristol-Myers Squibb

Observational

1,700

Haguenau, Saint-Herblain, Lille, Amiens, Toulon, Poitiers, Montpellier

2022-08-16

Active, closed

A Study of Ceralasertib Monotherapy and Ceralasertib Plus Durvalumab in Patients With Melanoma and Resistance to PD-(L)1 Inhibition

NCT05061134Melanoma

DrugsCeralasertib·Durvalumab

AstraZeneca

Phase 2

194

Bobigny, Boulogne-Billancourt, Marseille, Paris, Pau, Pierre-Bénite, Poitiers, Vandœuvre-lès-Nancy

2022-08-11

Active, closed

Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment

NCT05261399Carcinoma, Non-Small-Cell Lung

DrugsSavolitinib·Tagrisso·Osimertinib·Pemetrexed

AstraZeneca

Phase 3

341

Bobigny, Brest, Créteil, Dijon, Marseille, Paris, Poitiers, Rennes

2022-08-03

Active, closed

Safety and Pharmacokinetics Study of a Modified Tafasitamab IV Dosing Regimen Combined With Lenalidomide in R-R DLBCL Patients

NCT05222555Diffuse Large B Cell Lymphoma

DrugsTafasitamab·Lenalidomide

Incyte Corporation

Phase 1/2

Grenoble, Nantes, Le Mans, Poitiers

2022-07-19

Active, closed

Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma

NCT05352672Melanoma

DrugsFianlimab·Cemiplimab·Keytruda·Pembrolizumab

Regeneron Pharmaceuticals

Phase 3

1,546

Pierre-Bénite, Dijon, Besançon, Bordeaux, Lille, La Tronche, Poitiers, Rouen

2022-07-14

Active, closed

Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis

NCT05126277Lupus Nephritis

DrugIanalumab

Novartis Pharmaceuticals

Phase 3

452

Besançon, Bordeaux, Grenoble, Lyon, Marseille, Poitiers, Toulouse, Vandœuvre-lès-Nancy

2022-07-14

Active, closed

Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events

NCT05360446Coronary Artery Disease

DrugInclisiran sodium

Novartis Pharmaceuticals

Phase 3

610

Paris, Pessac, Poitiers, Toulouse

2022-07-08

Active, closed

SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM

NCT05405166Plasma Cell Myeloma Recurrent

DrugsParacetamol / Acetaminophen·Montelukast·Diphenhydramine·Isatuximab

Sanofi

Phase 3

531

Nantes, Paris, Poitiers, Saint-Priest-en-Jarez, Toulouse, Tours

2022-06-23

Recruiting

A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer

NCT05365581Gastric Adenocarcinoma, Gastroesophageal Junction (GEJ) Adenocarcinoma, Pancreatic Adenocarcinoma

DrugsASP2138·Ramucirumab·Fluorouracil·Leucovorin

Astellas Pharma Global Development, Inc.

Phase 1

398

Vaillant, Lyon, Marseille, Poitiers, Saint-Herblain, Toulouse

2022-06-07

Recruiting

A Study of YL201 in Patients With Advanced Solid Tumors

NCT05434234Advanced Solid Tumor

DrugTam-Peli

MediLink Therapeutics (Suzhou) Co., Ltd.

Phase 1/2

312

Bordeaux, Dijon, Marseille, Nantes, Paris, Poitiers, Saint-Herblain, Suresnes

2022-05-25

Active, closed

A Study of Talquetamab and Teclistamab Each in Combination With a Programmed Cell Death Receptor-1 (PD-1) Inhibitor for the Treatment of Participants With Relapsed or Refractory Multiple Myeloma

NCT05338775Relapsed/ Refractory Multiple Myeloma

DrugsTalquetamab·Teclistamab

Janssen Research & Development, LLC

Phase 1

Montpellier, Nantes, Poitiers, Toulouse

2022-05-25

Recruiting

Optimization of the Management of Non-Traumatic Intracerebral Hemorrhage (OPT-ICH)

NCT06802588Intracerebral Hemorrhage

University Hospital, Tours

Observational

600

Angers, Poitiers, Tours

2022-05-01

Recruiting

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

NCT05131022Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Diffuse Large B Cell Lymphoma (DLBCL), Follicular Lymphoma (FL)

DrugBexobrutideg

Nurix Therapeutics, Inc.

Phase 1

572

Angers, Bobigny, Nantes, Pessac, Poitiers, Saint-Cloud, Vandœuvre-lès-Nancy

2022-04-13

Active, closed

A Study of Rusfertide in Adults With Polycythemia Vera (PV)

NCT05210790Polycythemia Vera

DrugRusfertide

Protagonist Therapeutics, Inc.

Phase 3

293

Angers, Paris, Poitiers, Amiens, Argenteuil, Béziers, Pierre-Bénite

2022-04-11

Recruiting

Exploration of Differences in Metabolite Concentrations by 7Teslas NMR Spectroscopy in Striatum and Subthalamic Nuclei in de Novo Parkinsonian Patients and Control Subjects

NCT04735172Parkinson's Disease

University Hospital, Clermont-Ferrand

Not applicable

Clermont-Ferrand, Poitiers

2022-04-07

Active, closed

Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant

NCT05317416Multiple Myeloma

DrugsElranatamab·Lenalidomide

Pfizer

Phase 3

854

Toulouse, Paris, Villejuif, Poitiers, Lille, Pierre-Bénite, Tours

2022-03-25

Active, closed

A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

NCT05250973Amyloidosis

DrugsBortezomib·Daratumumab·Dexamethasone·Cyclophosphamide

Janssen Research & Development, LLC

Phase 2

151

Limoges, Pierre-Bénite, Poitiers, Toulouse

2022-03-01

Active, closed

Bintrafusp Alfa and Doxorubicin Hydrochloride in Treating Patients With Advanced Sarcoma

NCT04874311Advanced Soft-tissue Sarcoma, Metastatic Soft-tissue Sarcoma

DrugsBintrafusp alfa·Doxorubicin

Institut Bergonié

Phase 2

Bordeaux, Dijon, Lyon, Marseille, Paris, Poitiers

2022-03-01

Recruiting

Avalanche Phenomenon During Airways Opening in Acute Respiratory Distress Syndrome

NCT05224323Acute Respiratory Distress Syndrome

Poitiers University Hospital

Observational

Poitiers

2022-03-01

Recruiting

Interest of the Tool: Evaluation of Specific Care in an Ecological Environment for Patients Suffering From Schizophrenia-like Disorders

NCT05349513Patients With Schizophrenia-like Disorders

Centre Hospitalier Henri Laborit

Not applicable

Poitiers

2022-02-23

Recruiting

Better Understand Motor Deficits Associated With Autism Spectrum Disorders: Development of an Assessment Protocol

NCT05236803Autism Spectrum Disorder

Centre Hospitalier Charles Perrens, Bordeaux

Not applicable

110

Bordeaux, La Rochelle, Limoges, Poitiers

2022-02-07

Recruiting

Selective Internal Radiation Therapy and Capecitabine (Chemotherapy) Treatment for Liver Cancer

NCT05265208Resectable Intrahepatic Cholangiocarcinoma

DrugCapecitabine

Center Eugene Marquis

Phase 2

Rennes, Pessac, Montpellier, Poitiers, Villejuif, Clichy, Créteil

2022-02-04

Recruiting

Prospective Multicenter Study Evaluating Feasibility and Efficacy of Tumor Organoid-based Precision Medicine in Patients With Advanced Refractory Cancers

NCT05267912Advanced, Pretreated Solid Tumors

Gustave Roussy, Cancer Campus, Grand Paris

Not applicable

152

Bordeaux, Lille, Lyon, Paris, Poitiers, Reims, Rennes, Saint-Mandé

2022-01-19

Active, closed

A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments

NCT05152472Unresectable Gastrointestinal Stromal Tumor (GIST), Locally Advanced Gastrointestinal Stromal Tumor (GIST), Metastatic Gastrointestinal Stromal Tumor

DrugsGlivec·Imatinib·Tecentriq·Atezolizumab

Centre Leon Berard

Phase 2

Lyon, Bordeaux, Lille, Marseille, Nice, Poitiers, Reims, Rennes

2022-01-14

Active, closed

Anti-PD-1 and mDCF Followed by Chemoradiotherapy in Patients With Stage III Squamous Cell Anal Carcinoma.

NCT04719988Squamous Cell Carcinoma of the Anus Stage III

DrugBlood sample collection

Centre Hospitalier Universitaire de Besancon

Phase 2

Besançon, Dijon, Levallois-Perret, Lyon, Montbéliard, Nice, Paris, Poitiers

2022-01-04

Recruiting

Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia

NCT04925479Myeloid Leukemia, Philadelphia Positive

DrugABL001

Novartis Pharmaceuticals

Phase 1/2

Bordeaux, Lille, Paris, Poitiers

2021-12-27

Active, closed

A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

NCT05152147Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma

DrugsZanidatamab·Herceptin·Trastuzumab·Adrucil

Jazz Pharmaceuticals

Phase 3

920

Pessac, Avignon, Bordeaux, Dijon, Grenoble, Lyon, Nantes, Poitiers

2021-12-02

Recruiting

Adult Tic Disorders Registry

NCT05090943Tic Disorders

Assistance Publique - Hôpitaux de Paris

Observational

450

Clermont-Ferrand, Limoges, Marseille, Paris, Poitiers, Saint-Herblain, Strasbourg

2021-12-01

Recruiting

(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

NCT04910685Indolent Systemic Mastocytosis, Smoldering Systemic Mastocytosis

Blueprint Medicines Corporation

Phase 2/3

534

Amiens, Caen, Grenoble, Limoges, Nantes, Paris, Poitiers, Toulouse

2021-11-30

Recruiting

Predictive Multimodal MRI Factors in Subacute Cerebral Artery Occlusiontreated by Thrombectomy (PIMISUTT)

NCT04651010Middle Cerebral Artery Acute Ischemic Stroke

Poitiers University Hospital

Not applicable

Poitiers

2021-11-15

Recruiting

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

NCT04996875Advanced Systemic Mastocytosis (AdvSM), SM With an Associated Hematologic Neoplasm (SM-AHN), Mast Cell Leukemia (MCL), Aggressive Systemic Mastocytosis (ASM)

DrugBezuclastinib

Cogent Biosciences, Inc.

Phase 2

140

Paris, Poitiers, Toulouse

2021-11-09

Recruiting

Interest of CALR Allele Burden in Diagnosis and Follow-up of Patients With CALR Mutated Myeloproliferative Syndromes (CALRSUIVI)

NCT04942080Myeloproliferative Neoplasm, Essential Thrombocythemia, Primary Myelofibrosis, Prefibrotic Stage, Primary Myelofibrosis, Fibrotic Stage

University Hospital, Angers

Not applicable

260

Angers, Bordeaux, Brest, Cholet, Le Mans, Morlaix, Paris, Poitiers

2021-10-28

Active, closed

A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma

NCT05083169Multiple Myeloma

DrugsTeclistamab·Pomalidomide·Bortezomib·Daratumumab

Janssen Research & Development, LLC

Phase 3

587

Créteil, Lille, Limoges, Lyon, Nantes, Poitiers, Strasbourg, Toulouse

2021-10-14

Recruiting

Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode

NCT03646058Suicidal Ideation, Major Depressive Episode

DrugBuprenorphine

Centre Hospitalier Universitaire de Nīmes

Phase 3

180

Bordeaux, Le Kremlin-Bicêtre, Lyon, Nantes, Nîmes, Paris, Poitiers, Toulouse

2021-10-10

Active, closed

Impact of the Microbiota on the Likelihood of Renal Graft Rejection

NCT04736381Kidney Transplant Rejection

DrugBelatacept

Institut National de la Santé Et de la Recherche Médicale, France

Observational

Besançon, La Tronche, Nantes, Paris, Poitiers, Toulouse, Tours

2021-10-07

Recruiting

A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments

NCT05020236Multiple Myeloma

DrugsDarzalex·Elranatamab·Pomalidomide·Daratumumab

Pfizer

Phase 3

893

Limoges, Lille, Nantes, Paris, Pierre-Bénite, Poitiers, Toulouse

2021-10-04

Recruiting

A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma

NCT04973605Relapsed/Refractory Multiple Myeloma

DrugsSonrotoclax·Carfilzomib·Pomalidomide·Daratumumab

BeOne Medicines

Phase 1/2

246

Poitiers

2021-09-16

Recruiting

Identification of Asymptomatic Patients at Very High Cardiovascular Risk: Contribution of a Strategy Based on Carotid and Coronary Explorations, Compared to Simple Risk Calculation Using the European "SCORE 2" Algorithm. (IDEA-CVR)

NCT07252830Myocardial Infarction, Atheroma, Cholesterol, Cardiovascular (CV) Risk

Elsan

Observational

1,000

Poitiers

2021-09-12

Active, closed

Safety, Tolerability, Pharmacokinetics and Efficacy Study of Radotinib in Parkinson's Disease

NCT04691661Parkinson Disease

DrugRadotinib HCl

Il-Yang Pharm. Co., Ltd.

Phase 2

Lille, Limoges, Lyon, Nantes, Paris, Poitiers, Rouen

2021-09-09

Recruiting

Clinical Trial Assessing the Immunogenicity of an Anti-pneumococcal Vaccination Strategy (PCV13+PPV23 Versus PREVENAR20) in Adult Patients Treated for a Lymphoma

NCT04460235Vaccine, Streptococcus Pneumoniae, Lymphoma, Non-Hodgkin

Poitiers University Hospital

Phase 4

160

Angers, Bordeaux, Limoges, Nantes, Périgueux, Poitiers, Tours

2021-09-07

Recruiting

Bilateral Lateral OFC rTMS in Obsessive Compulsive Disorder

NCT04934007Obsessive-Compulsive Disorder

Centre Hospitalier Henri Laborit

Not applicable

136

Paris, Poitiers

2021-09-06

Active, closed

Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC

NCT04919811Non Small Cell Lung Cancer

DrugTaletrectinib

Nuvation Bio Inc.

Phase 2

217

Bron, La Tronche, Lyon 08, Marseille, Paris, Poitiers, Reims, Rennes

2021-09-01

Recruiting

Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment

NCT04956016Depressive Disorder, Treatment-Resistant

Centre Hospitalier Henri Laborit

Not applicable

152

Poitiers

2021-08-23

Active, closed

A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy

NCT04923893Multiple Myeloma

DrugsCilta-cel·Bortezomib·Lenalidomide·Fludarabine

Janssen Research & Development, LLC

Phase 3

743

Lille, Nantes, Paris, Poitiers, Toulouse

2021-08-19

Recruiting

Efficacy and Safety of MB-CART2019.1 vs. SoC in Lymphoma Patients

NCT04844866Diffuse Large B-cell Lymphoma

Miltenyi Biomedicine GmbH

Phase 2

213

Créteil, Lille, Lyon, Marseille, Nantes, Pessac, Poitiers, Toulouse

2021-08-18

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT04910568Multiple Myeloma

DrugsCevostamab·Pomalidomide·Tocilizumab·Daratumumab

Genentech, Inc.

Phase 1

186

Paris, Poitiers, Rennes

2021-07-26

Active, closed

Sleeve Gastrectomy With Transit Bipartition(SG+TB) Versus Roux-en-Y Gastric Bypass (RYGB) for Type 3 Obesity

NCT04915014Severe Obesity

University Hospital, Lille

Not applicable

320

Lille, Lyon, Nantes, Orléans, Paris, Poitiers, Vandœuvre-lès-Nancy

2021-07-23

Active, closed

Multicenter Open Label Phase 3 Study of Isatuximab Plus Lenalidomide and Dexamethasone With/Without Bortezomib in the Treatment of Newly Diagnosed Non Frail Transplant Ineligible Multiple Myeloma Elderly Patients (≥ 65; < 80 Years).

NCT04751877Multiple Myeloma, Myeloma

DrugsIsatuximab·Bortezomib·Lenalidomide·Dexamethasone

Poitiers University Hospital

Phase 3

270

Poitiers

2021-07-17

Recruiting

CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

NCT05002543Cardiac Valve Disease

Corcym S.r.l

Observational

2,150

Clermont-Ferrand, Lens, Poitiers, Toulouse

2021-06-29

Recruiting

Interest of the 7 Tesla MRI in the Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury

NCT04982562Post-Concussion Syndrome

Poitiers University Hospital

Not applicable

100

Poitiers

2021-06-26

Active, closed

Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).

NCT04895722Colorectal Cancer

DrugsPembrolizumab/Vibostolimab·MK-4830·Pembrolizumab/Favezelimab·Pembrolizumab/Quavonlimab

Merck Sharp & Dohme LLC

Phase 2

302

Marseille, Dijon, Toulouse, Lille, Poitiers, Paris

2021-06-25

Recruiting

Study to Evaluate the Performance and Safety of ATF Implants and Lapé Médical Devices Implanted During Hip Arthroplasty

NCT05044767Arthroplasty, Hip, Replacement

ATF Implants

Observational

4,500

Bordeaux, Cornebarrieu, Échirolles, Guilherand-Granges, Marcq-en-Barœul, Nice, Paris, Poitiers

2021-06-07

Recruiting

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

NCT04614103Metastatic Non Small Cell Lung Cancer

DrugLifileucel

Iovance Biotherapeutics, Inc.

Phase 2

170

Marseille, Nantes, Nice, Pierre-Bénite, Poitiers, Villejuif

2021-05-07

Active, closed

Innate T Cells and TKI Discontinuation

NCT04645706Chronic Myeloid Leukemia

Poitiers University Hospital

Observational

Poitiers

2021-04-20

Active, closed

A Study of Ixekizumab (LY2439821) in Children With Juvenile Idiopathic Arthritis Categories of Enthesitis-related Arthritis (Including Juvenile Onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis

NCT04527380Juvenile Psoriatic Arthritis, Enthesitis Related Arthritis

DrugsIxekizumab·Adalimumab

Eli Lilly and Company

Phase 3

101

Bron, Montpellier, Le Kremlin-Bicêtre, Poitiers, Paris

2021-04-13

Active, closed

Atezolizumab Combined With BDB001 AnD Immunogenic Radiotherapy in Patients With Advanced Solid Tumors

NCT03915678Solid Tumor, Adult, Pancreatic Cancer, Virus-associated Tumors, Non Small Cell Lung Cancer

Institut Bergonié

Phase 2

247

Bordeaux, Brest, Caen, Dijon, Lille, Marseille, Paris, Poitiers

2021-03-31

Recruiting

Comparative Study of Gender Identity Disorder Versus Control

NCT04935164Gender Dysphoria, Adult

Centre Hospitalier Henri Laborit

Observational

120

Poitiers

2021-03-26

Active, closed

PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS

NCT04664465Inflammatory Rheumatism, Polymyalgia Rheumatica, Giant Cell Arteritis, Idiopathic Inflammatory Myopathies

University Hospital, Brest

Observational

300

Angers, Brest, La Roche-sur-Yon, Le Mans, Morlaix, Nantes, Orléans, Poitiers

2021-03-18

Recruiting

Interest of Circulating Tumor DNA in Digestive and Gynecologic/Breast Cancer

NCT04530890Breast Cancer, Digestive Cancer, Gynecologic Cancer, Circulating Tumor DNA

Poitiers University Hospital

Not applicable

1,000

Poitiers

2021-03-08

Recruiting

Virtual Biopsy Development to Identify Patient's Glioma Grade at the CHU of Poitiers Using Magnetic Resonance Imaging

NCT04313140Development of the Virtual Biopsy, Tumor Grade, Artificial Intelligence Algorithms, Clinical

Poitiers University Hospital

Not applicable

500

Poitiers

2021-02-22

Active, closed

Galinpepimut-S Versus Investigator's Choice of Best Available Therapy for Maintenance in AML CR2/CRp2

NCT04229979Acute Myeloid Leukemia

DrugsGm-Csf·Sargramostim·Ara-C·Decitabine

Sellas Life Sciences Group

Phase 3

127

Amiens, Angers, Caen, Grenoble, Nantes, Paris, Pierre-Bénite, Poitiers

2021-02-08

Recruiting

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

NCT04657068Advanced Cancer, Metastatic Cancer, Ovarian Cancer, Primary Peritoneal Cancer

DrugsIrinotecan·Gemcitabine

Artios Pharma Ltd

Phase 1/2

542

Villejuif, Paris, Poitiers, Bordeau, Marseille

2021-01-27

Active, closed

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

NCT04657991Melanoma

DrugsEncorafenib·Binimetinib·Keytruda·Pembrolizumab

Pfizer

Phase 3

257

Amiens, La Tronche, Pierre-Bénite, Poitiers

2021-01-15

Active, closed

Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)

NCT04656652Non-small Cell Lung Cancer

DrugsDato-DXd·Docetaxel

Daiichi Sankyo

Phase 3

605

Besançon, Grenoble, Lyon, Marseille, Nantes, Paris, Poitiers, Rennes

2020-12-21

Active, closed

A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers

NCT04626635Advanced Solid Tumors

DrugsMarlotamig·Trifluridine/Tipiracil·Cemiplimab·Bevacizumab

Regeneron Pharmaceuticals

Phase 1/2

548

Lyon, Pierre-Bénite, Dijon, Toulouse, Lille, Bordeaux, Poitiers, Nantes

2020-12-21

Recruiting

Optimizing Long-term Survival in Organ Transplantation: From Physiopathology to Optimized Patient Management

NCT03997253Organ Transplantation

University Hospital, Limoges

Not applicable

430

Limoges, Poitiers, Rennes, Tours

2020-12-21

Active, closed

A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)

NCT04546009Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer

DrugsGiredestrant·Palbociclib·Letrozole

Hoffmann-La Roche

Phase 3

992

Angers, Bayonne, La Roche-sur-Yon, Montpellier, Poitiers, Reims, Rennes, Saint-Priest-en-Jarez

2020-10-09

Recruiting

Subcutaneous Injections of ASC to Heal Digital Ulcers in Patients With Scleroderma.

NCT04356755Systemic Sclerosis

DrugAdMSC

University Hospital, Toulouse

Phase 2

Grenoble, Lille, Marseille, Montpellier, Nantes, Poitiers, Toulouse

2020-09-22

Active, closed

A Study of Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT04557098Hematological Malignancies

DrugTeclistamab

Janssen Research & Development, LLC

Phase 2

194

Lille, Lyon, Nantes, Poitiers, Toulouse, Tours

2020-09-17

Active, closed

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)

NCT04504825AL Amyloidosis

DrugsAnselamimab·Cyclophosphamide, bortezomib, and dexamethasone (CyBorD)

Alexion Pharmaceuticals, Inc.

Phase 3

125

Caen, Créteil, Limoges, Marseille, Paris, Pessac, Pierre-Bénite, Poitiers

2020-08-25

Recruiting

Induction Chemotherapy Followed by Standard Therapy in Cervical Cancer With Aortic Lymph Node Spread

NCT03534713Cervical Cancer TNM Staging Regional Lymph Nodes (N)

DrugsCarbo·Platinol·Taxol·Paclitaxel

University Hospital, Toulouse

Phase 3

310

Bordeaux, Clermont-Ferrand, Créteil, Marseille, Pierre-Bénite, Poitiers, Saint-Herblain, Saint-Pierre

2020-07-17

Active, closed

A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease

NCT04232553Crohn's Disease

DrugMirikizumab

Eli Lilly and Company

Phase 3

996

Montpellier, Vandœuvre-lès-Nancy, Poitiers

2020-06-22

Active, closed

Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

NCT04270409Plasma Cell Myeloma

DrugsMontelukast·Diphenhydramine·Acetaminophen·Isatuximab

Sanofi

Phase 3

337

Ars-Laquenexy, Bayonne, Grenoble, La Roche-sur-Yon, Lille, Paris, Poitiers, Rennes

2020-06-16

Recruiting

Platelet Inhibitor Treated Patients With Head Injury Trauma Meeting NICE Criteria : is the CT-scan Mandatory ?

NCT03687528Head Injury Trauma, Emergencies

Rennes University Hospital

Observational

3,200

Angers, Brest, Chartres, Le Mans, Lorient, Nantes, Poitiers, Quimperlé

2020-06-15

Active, closed

A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma

NCT04181827Multiple Myeloma

DrugsCilta-cel·Pomalidomide·Bortezomib·Daratumumab

Janssen Research & Development, LLC

Phase 3

419

Lille, Lyon, Montpellier, Nantes, Paris, Poitiers, Toulouse

2020-06-12

Recruiting

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

NCT04389632Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck, HER2 Negative Breast Neoplasms, Esophageal Squamous Cell Carcinoma

DrugsSigvotatug vedotin·Keytruda·Cisplatin·Carboplatin

Seagen, a wholly owned subsidiary of Pfizer

Phase 1

1,006

Angers, Nice, Poitiers, Vandœuvre-lès-Nancy, Villejuif

2020-06-08

Active, closed

Study of HPN217 in Participants With Relapsed/Refractory Multiple Myeloma MK-4002 (MK-4002-001)

NCT04184050Multiple Myeloma in Relapse, Multiple Myeloma, Multiple Myeloma of Bone, Multiple Myeloma With Failed Remission

Harpoon Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 1

100

Nantes, Poitiers

2020-04-13

Active, closed

Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

NCT04162210Multiple Myeloma

DrugsBelantamab mafodotin·Dexamethasone

GlaxoSmithKline

Phase 3

325

Le Mans, Montpellier, Poitiers

2020-04-02

Active, closed

First-in-Human Study of ICT01 in Patients With Advanced Cancer

NCT04243499Solid Tumor, Adult, Hematopoietic/Lymphoid Cancer

ImCheck Therapeutics, an Ipsen company

Phase 1/2

293

Bordeaux, Lyon, Marseille, Nantes, Nice, Paris, Poitiers

2020-03-05

Recruiting

Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas

NCT04055220Bone Sarcoma, Osteosarcoma, Ewing Sarcoma, Chondrosarcoma

DrugRegorafenib

Centre Leon Berard

Not applicable

168

Besançon, Bordeaux, Lille, Lyon, Marseille, Montpellier, Paris, Poitiers

2020-03-03

Active, closed

A Study of Baricitinib (LY3009104) in Participants From 1 Year to Less Than 18 Years Old With Systemic Juvenile Idiopathic Arthritis (sJIA)

NCT04088396Systemic Juvenile Idiopathic Arthritis

DrugsBaricitinib·Tocilizumab

Eli Lilly and Company

Phase 3

Bron, Le Kremlin-Bicêtre, Nîmes, Paris, Poitiers

2020-02-12

Active, closed

DS8201a and Pembrolizumab in Participants With Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer

NCT04042701Breast Cancer, Non-small Cell Lung Carcinoma

DrugsTrastuzumab deruxtecan·Keytruda·Pembrolizumab

Daiichi Sankyo

Phase 1

115

Bordeaux, Créteil, Marseille, Marsielle, Poitiers, Toulouse, Villejuif

2020-02-10

Recruiting

Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors

NCT03934372Acute Myeloid Leukemia, Accelerated Phase Chronic Myeloid Leukemia, Blast Phase Chronic Myeloid Leukemia, Chronic Phase Chronic Myeloid Leukemia

DrugPonatinib

Incyte Biosciences International Sàrl

Phase 1/2

Paris, Poitiers, Rennes

2020-01-29

Recruiting

Assessment of Complication Risk Factors in a French National Cohort of Asplenic Patients

NCT04199403Asplenia

Poitiers University Hospital

Observational

6,000

Angoulême, Argenteuil, Béthune, Chartres, Lille, Montpellier, Nantes, Poitiers

2020-01-09

Active, closed

Study of Belantamab Mafodotin Plus Standard of Care (SoC) in Newly Diagnosed Multiple Myeloma

NCT04091126Multiple Myeloma

DrugsBelantamab mafodotin·Bortezomib·Lenalidomide·Dexamethasone

GlaxoSmithKline

Phase 1

118

Poitiers

2019-12-18

Recruiting

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

NCT04176198Myelofibrosis

DrugsMomelotinib·Ruxolitinib

Sumitomo Pharma America, Inc.

Phase 1/2

240

Amiens, Angers, Lyon, Nice, Nîmes, Paris, Poitiers, Villejuif

2019-12-16

Active, closed

A Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer Therapies

NCT03888105B-cell Non-Hodgkin Lymphoma (B-NHL)

DrugOdronextamab

Regeneron Pharmaceuticals

Phase 2

515

Pessac, Caen, Pierre-Bénite, Lille, Nantes, Poitiers, Paris, Créteil

2019-11-13

Active, closed

Clinical and Neurobiological Profile Predictive of Pejorative Outcome of Depression

NCT03690856Depression

Rennes University Hospital

Not applicable

Angers, Brest, Nantes, Poitiers, Rennes, Saint-Avé, St-Malo, Tours

2019-11-08

Active, closed

Weaning From High Flow Nasal Oxygen in Acute Respiratory Failure : a Target Trial Emulation

NCT07030413Respiratory Failure With Hypoxia, Respiratory Failure, ICU, High-Flow Nasal Oxygen Therapy

Poitiers University Hospital

Observational

2,000

Bordeaux, Limoges, Poitiers

2019-11-01

Active, closed

A Study of Baricitinib (LY3009104) in Participants From 2 Years to Less Than 18 Years Old With Active JIA-Associated Uveitis or Chronic Anterior Antinuclear Antibody-Positive Uveitis

NCT04088409Uveitis

DrugsBaricitinib·Adalimumab

Eli Lilly and Company

Phase 3

Le Kremlin-Bicêtre, Paris, Poitiers

2019-10-16

Active, closed

A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer

NCT04077463Carcinoma, Non-Small-Cell Lung

DrugsLazertinib·Amivantamab·Pemetrexed·Carboplatin

Janssen Research & Development, LLC

Phase 1

701

Bordeaux, Lyon, Marseille, Paris, Poitiers, Saint-Mandé, Villejuif

2019-09-04

Active, closed

Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia

NCT04119050Warm Autoimmune Hemolytic Anemia

DrugNipocalimab

Janssen Research & Development, LLC

Phase 2/3

118

Amiens, Brest, Dijon, La Tronche, Nantes, Poitiers

2019-08-15

Active, closed

Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)

NCT03974022Non-Small Cell Lung Cancer

DrugSunvozertinib

Dizal Pharmaceuticals

Phase 1/2

315

Angers, Bron, Dijon, Hellemmes-Lille, Marseille, Montpellier, Paris, Poitiers

2019-07-09

Active, closed

Durvalumab or Placebo in Combination With Gemcitabine/Cisplatin in Patients With 1st Line Advanced Biliary Tract Cancer (TOPAZ-1)

NCT03875235Biliary Tract Neoplasms

DrugDurvalumab

AstraZeneca

Phase 3

810

Clichy, Dijon, Montpellier, Nice, Paris, Pessac, Poitiers

2019-04-16

Recruiting

A Study of Baricitinib in Participants From 1 Year to Less Than 18 Years Old With Juvenile Idiopathic Arthritis

NCT03773965Juvenile Idiopathic Arthritis

DrugBaricitinib

Eli Lilly and Company

Phase 3

190

Bron, Le Kremlin-Bicêtre, Nîmes, Paris, Poitiers

2019-04-05

Active, closed

Avelumab Program Rollover Study

NCT03815643Solid Tumors

DrugAvelumab

EMD Serono Research & Development Institute, Inc.

Phase 3

205

Besançon, Lille, Nantes, Nice, Paris, Pessac, Poitiers, Strasbourg

2019-03-22

Active, closed

A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors

NCT03845166Neoplasm Malignant, Renal Cell Carcinoma, Hormone Receptor Positive Breast Carcinoma, Metastatic Castration-resistant Prostate Cancer

DrugsZanzalintinib·Avelumab·Tecentriq·Atezolizumab

Exelixis

Phase 1

325

Clermont, Saint-Herblain, Bordeaux, Caen, Marseille, Paris, Pierre-Bénite, Poitiers

2019-03-20

Active, closed

A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib

NCT03673501Gastrointestinal Stromal Tumors

DrugsRipretinib·Sunitinib

Deciphera Pharmaceuticals, LLC

Phase 3

453

Bordeaux, Dijon, Lille, Lyon, Marseille, Paris, Poitiers, Saint-Herblain

2019-02-08

Active, closed

Detection of Brain Metastasis by MRI in Metastatic Colorectal Cancer Patients

NCT03694938Metastatic Colon Cancer

Poitiers University Hospital

Not applicable

143

Amiens, Lyon, Poitiers, Tours

2019-02-07

Active, closed

Paclitaxel + Carboplatin + Durvalumab With or Without Oleclumab for Previously Untreated Locally Recurrent Inoperable or Metastatic TNBC

NCT03616886Triple Negative Breast Cancer

DrugsOleclumab·Durvalumab·Paclitaxel·Carboplatin

Jules Bordet Institute

Phase 1/2

129

Besançon, Bordeaux, Dijon, Marseille, Nice, Paris, Poitiers, Rouen

2018-12-28

Recruiting

Chronic Pulmonary Aspergillosis and Ambisome Aerosol with Itraconazole

NCT03656081Chronic Pulmonary Aspergillosis

DrugsAmbisome·Itraconazole

Poitiers University Hospital

Phase 3

224

Poitiers

2018-12-19

Active, closed

Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

NCT03742895Advanced Solid Neoplasms

DrugOlaparib

Merck Sharp & Dohme LLC

Phase 2

329

Poitiers, Nice, Strasbourg, Dijon, Bordeaux, Villejuif

2018-12-12

Active, closed

Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC

NCT03732677Muscle Invasive Bladder Cancer

DrugsDurvalumab·Gemcitabine·Cisplatin

AstraZeneca

Phase 3

1,063

Angers, Dijon, Grenoble, Montpellier, Nîmes, Pierre-Bénite, Poitiers, Rouen

2018-11-16

Recruiting

Medical-economic Evaluation of the Care of Refractory Ascites by Implantation of Alfapump® Device in Cirrhotic Patients

NCT03506893Ascites, Paracentesis, Cirrhosis

University Hospital, Grenoble

Not applicable

Amiens, Angers, Besançon, Bordeaux, Clichy, Grenoble, Paris, Poitiers

2018-07-17

Active, closed

A Study of Zolbetuximab (IMAB362) in Adults With Gastric Cancer

NCT03505320Pharmacokinetics of Zolbetuximab, Gastric Cancer, Gastro-esophageal Junction (GEJ) Cancer, Pharmacokinetics of Oxaliplatin

DrugsFolinic acid·Zolbetuximab·Fluorouracil·Leucovorin

Astellas Pharma Global Development, Inc.

Phase 2

143

Pessac, Poitiers, Brest, Paris

2018-06-29

Active, closed

A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma

NCT03470922Melanoma

DrugsRelatlimab·Nivolumab

Bristol-Myers Squibb

Phase 2/3

714

Rennes, Amiens, Bordeaux, Lille, Marseille, Paris, Pierre-Bénite, Poitiers

2018-04-11

Active, closed

A Study of Combination Therapy With Venetoclax, Daratumumab and Dexamethasone (With and Without Bortezomib) in Participants With Relapsed or Refractory Multiple Myeloma

NCT03314181Multiple Myeloma

DrugsVenclexta·Bortezomib·Daratumumab·Venetoclax

AbbVie

Phase 2

156

Limoges, Tours, Nantes, Villejuif, Poitiers, Paris

2018-04-02

Active, closed

iRECIST Evaluation's Relevance for DCR in MMR/MSI Metastatic Colorectal Cancer Patients on Nivolumab and Ipilimumab

NCT03350126Metastatic Cancer Colorectal

DrugsIpilimumab·Nivolumab

GERCOR - Multidisciplinary Oncology Cooperative Group

Phase 2

Avignon, Besançon, Créteil, Levallois-Perret, Lyon, Nantes, Paris, Poitiers

2017-12-04

Active, closed

Cognitive Behavioural Group Therapy Versus Individual Supportive Therapy for the Prevention of Repeat Suicide Attempts

NCT02664701Suicidal Ideation, Suicide, Attempt

Centre Hospitalier Universitaire de Nīmes

Not applicable

240

Clermont-Ferrand, Lyon, Montpellier, Nîmes, Paris, Poitiers, Saint-Cyr-sur-Loire, Strasbourg

2017-10-17

Active, closed

A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)

NCT03178552Non-Small Cell Lung Cancer

DrugsCobimetinib·Divarasib·Vemurafenib·Entrectinib

Hoffmann-La Roche

Phase 2/3

1,000

Bordeaux, Caen, Lille, Lyon, Nîmes, Nouilly, Paris, Poitiers

2017-09-22

Active, closed

Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom

NCT02952508Waldenstrom Macroglobulinemia, Multiple Myeloma, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugCLR 131

Cellectar Biosciences, Inc.

Phase 2

120

Pessac, Poitiers

2017-07-26

Active, closed

A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease

NCT03100149Parkinson's Disease

DrugPrasinezumab

Hoffmann-La Roche

Phase 2

316

Bordeaux, Clermont-Ferrand, Créteil, Grenoble, Marseille, Nice, Paris, Poitiers

2017-06-27

Active, closed

A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

NCT03165734Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis

DrugPacritinib

Swedish Orphan Biovitrum

Phase 3

407

Amiens, Nîmes, Marseille, Paris, Pessac, Pierre-Bénite, Poitiers

2017-06-26

Recruiting

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

NCT03093116Locally Advanced Solid Tumors, Metastatic Solid Tumors

DrugRepotrectinib

Turning Point Therapeutics, Inc.

Phase 1/2

500

Marseille, Brest, Dijon, Grenoble, Nice, Poitiers, Saint-Mandé, Villejuif

2017-03-07

Active, closed

A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma

NCT02773030Multiple Myeloma

DrugsIberdomide·Darzalex·Velcade·Carfilzomib

Celgene

Phase 1/2

466

Lile Cedax, Pessac, Pierre-Bénite, Poitiers

2016-10-14

Recruiting

Two Therapeutic Strategies in First-line in Patients With Epithelial Advanced Ovarian Cancer

NCT03025477Ovarian Cancer, Epithelial

Groupe Hospitalier Diaconesses Croix Saint-Simon

Phase 2

Dijon, Levallois-Perret, Paris, Poissy, Poitiers, Senlis

2016-10

Active, closed

A Long Term Safety Study of ND0612 Administered as a Continuous SC Infusion in Advanced Parkinson's Disease

NCT02726386Parkinson's Disease

NeuroDerm Ltd.

Phase 2

214

Aix-en-Provence, Amiens, Bron, Clermont-Ferrand, Lille, Marseille, Poitiers

2016-05-04

Active, closed

Study to Evaluate Imetelstat (GRN163L) in Participants With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)

NCT02598661Myelodysplastic Syndromes

DrugImetelstat Sodium

Geron Corporation

Phase 2/3

289

Nice, Tours, Limoges, La Tronche, Vandœuvre-lès-Nancy, Le Mans, Poitiers, Angers

2016-01-12

Active, closed

Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer

NCT02516241Urothelial Cancer

DrugsTremelimumab·Durvalumab·Gemcitabine·Cisplatin

AstraZeneca

Phase 3

1,126

Bordeaux, Caen, Lyon, Marseille, Paris, Poitiers, Suresnes, Toulouse

2015-11-02

Active, closed

A Study of Ramucirumab (LY3009806) in Combination With Erlotinib in Previously Untreated Participants With EGFR Mutation-Positive Metastatic NSCLC (RELAY)

NCT02411448Metastatic Non-Small Cell Lung Cancer

DrugsGefitinib·Erlotinib·Ramucirumab·Osimertinib

Eli Lilly and Company

Phase 3

545

Montpellier, La Tronche, Lille, Poitiers, Paris

2015-05-06

By invitation

Registry of Patients With Hypophosphatasia

NCT02306720Hypophosphatasia (HPP)

Alexion Pharmaceuticals, Inc.

Observational

1,571

Toulouse, Lille, Paris, Poitiers, Lyon, Le Kremlin-Bicêtre

2015-01-20

Active, closed

A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer

NCT02152631Non Small Cell Lung Cancer

DrugsErlotinib·Abemaciclib

Eli Lilly and Company

Phase 3

453

Bron, Dijon, Grenoble, Lille, Marseille, Poitiers, Rennes, Saint-Brieuc

2014-10-03

Active, closed

An Open-label, Phase 2 Study of ACP-196 in Subjects With Waldenström Macroglobulinemia

NCT02180724Waldenström Macroglobulinemia (WM)

DrugAcalabrutinib

Acerta Pharma BV

Phase 2

107

Aurillac, Clermond Ferrand, Marseille, Montpellier, Nantes, Paris, Pierre-Bénite, Poitiers

2014-09-11

Recruiting

Post Traumatic Critical Complications: a Prospective Cohort Study (ATLANREA)

NCT02426255Severe Trauma (With or Without Traumatic Brain Injury)

Nantes University Hospital

Observational

5,000

Angers, Nantes, Poitiers, Rennes, Tours

2013-03-29

Recruiting

Non Traumatic Neuro-Vascular Diseases Critical Complications : a Prospective Cohort Study

NCT02714387Non Traumatic Acute Brain Injury

Nantes University Hospital

Observational

5,000

Angers, Brest, Nantes, Poitiers, Rennes, Tours

2013-02

Recruiting

Patient Retrospective Outcomes (PRO)

NCT01550575Chronic Pain

Boston Scientific Corporation

Observational

15,000

Caen, Créteil, Lyon, Nantes, Paris, Poitiers, Saint-Herblain, Suresnes

2012-04-03

Recruiting

International Chronic Myeloid Leukemia Pediatric Study

NCT01281735Chronic Myeloid Leukemia

Poitiers University Hospital

Observational

750

Poitiers

2011-01

Recruiting

Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals

NCT06973174Sepsis, Infections

Centre Hospitalier Universitaire de Nice

Observational

Nice, Lille, Marseille, Nantes, Nîmes, Paris, Poitiers, Rennes

2010-01-01

Recruiting

Prognostic and Predictive Markers of Treatment Response in Patients With PAC.

NCT05776342Pancreatic Adenocarcinoma

GERCOR - Multidisciplinary Oncology Cooperative Group

Observational

4,050

Besançon, Clichy, Créteil, Lille, Lyon, Nancy, Paris, Poitiers

2003-01-01

Cite this view

Priya Life Science (2026). Clinical trial register: studies with a French investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 2 November 2026. https://priyalifescience.com/clinical-trials-france/city/poitiers

Query this register directly

GET /api/trials?country=in&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in France and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,731 studies in total at the last sync on 02 Nov 2026, 03:18 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 351 of those studies with a site in Poitiers.

How many clinical trials are recruiting in Poitiers?

203 of the 351 studies on this page are recruiting new participants as of the 02 Nov 2026, 03:18 UTC sync. A further 26 have not yet opened recruitment, 118 are active but closed to new participants, and 4 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Poitiers), 351 studies
Phase	Studies	Recruiting	Share
Phase 3	111	53	31.6%
Not applicable	83	62	23.6%
Phase 2	58	24	16.5%
Observational	47	31	13.4%
Phase 1/2	23	16	6.6%
Phase 1	16	9	4.6%
Phase 2/3	10	6	2.8%
Phase 4	2	1	0.6%
Early Phase 1	1	1	0.3%

Most active sponsors

Lead sponsors with the most studies (Poitiers)
Lead sponsor	Studies	Recruiting
Poitiers University Hospital	49	33
AstraZeneca	17	7
Centre Hospitalier Henri Laborit	15	14
Janssen Research & Development, LLC	13	5
Regeneron Pharmaceuticals	11	6
Eli Lilly and Company	10	3
Novartis Pharmaceuticals	10	7
Hoffmann-La Roche	8	4
Nantes University Hospital	8	6
Pfizer	7	4

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.