Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals

Condition(s) studied

Investigational drug(s) / intervention(s)

Premature neonates with invasive infection caused by Bacillus cereus: The whole genome sequencing of the bacterial strains was performed by using both Illumina and Nanopore technologies, allowing us to obatin high quality and complete circular genomes.

Study summary

Background. Bacillus cereus group (Bc) comprises twenty-six closely related species of spore-forming environmental bacteria. Recently, increased sepsis and septic shock caused by Bc were reported in preterm neonates (PN), and the mortality rate can reach up to 30%. Using Whole Genome Sequencing (WGS) increasingly used to characterize Bc strains, The team aimed to determine an accurate identification to the species level of the strains involved in Bc invasive infections in preterm neonates in France and study their virulome profile.Methods. The team performed WGS for 40 neonate clinical strains responsible for invasive infections in PN. A screening of virulence genes was performed to characterize strains associated with poor prognosis. Clinical data were collected and all clinical and genomic findings were analyzed for risk factors for death.

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Eligibility

Primary outcome measure(s)

• Mortality — 28 days after birth
  The mortality at D28 after birth was collected in patients record.

Trial sites (13)

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