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Clinical Trials in France / NCT05596539
Recruiting Observational

Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO)

NCT05596539 · tracked via the Priya Life Science France tracker
Sponsor
Assistance Publique - Hôpitaux de Paris
Phase
Observational
Started
2023-03-22
Last updated
2026-08-05

Condition(s) studied

Hypophosphatasia

Investigational drug(s) / intervention(s)

Data collection

Data collection: Collection data from diagnostic Data collected following to medical exam as part of care

Study summary

The purpose of this study is to assess medical events during follow-up of adult patients having hypophosphatasia and consulting rheumatologists.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * men and women, * aged 18 and over, with no upper age limit, who have had a total alkaline phosphatase value of less than 40 IU/l on at least 3 occasions, or at least a total alkaline phosphatase value below 40 IU/L and evidence of ALPL gene polymorphism * with at least one rheumatological symptom. Exclusion Criteria: * transient hypophosphatasia: absence of confirmation of a value below 40 IU/l on at least 3 samples, lack of genetic confirmation * secondary hypophosphatasia according to the expert rheumatologist (drugs, endocrine disease, other genetic disease...).

Primary outcome measure(s)

  • Characterise the circumstances of diagnosis, and deduce ways to reduce the diagnostic delay of hypophosphatasia in adults. — At inclusion
    Time since first symptom due to hypophosphatasia

Trial sites (11)

FacilityCityRegionStatus
CHU de Bordeaux- Hôpital Pellegrin Place Amélia Raba Léon - 12è étage - Rhumatologie - Bordeaux France Recruiting
CHU Lille Lille France Recruiting
Hospices Civils de Lyon Lyon France Recruiting
CHU Nice Nice France Recruiting
Lariboisière Hospital Paris France Recruiting
Cochin Hospital Paris France Recruiting
CHU Poitiers Poitiers France Recruiting
CHU Rennes Rennes France Recruiting
CHU Saint-Etienne Saint-Priest-en-Jarez France Recruiting
Les hôpitaux universitaires de Strasbourg Strasbourg France Recruiting
CHU de Toulouse Toulouse France Recruiting

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Other trials for the same condition

Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05596539 on ClinicalTrials.gov ↗ ← All trials in France