PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS

Condition(s) studied

Study summary

To date, there is no available tool that allows, at individual level, determination of the probability to develop clinically relevant complications of prolonged glucocorticoid therapy. In patients with inflammatory rheumatic disorders requiring prolonged glucocorticoid therapy, such tool could be useful to adapt first-line treatment decisions (in daily practice and in future clinical trials). The main objective of the study is to identify routine clinical, biological and DXA baseline characteristics predictive of the occurrence of clinically relevant complications of glucocorticoid therapy at 1 year, in order to propose a predictive score.

Eligibility

Primary outcome measure(s)

• Clinically relevant complication of glucocorticoid therapy — 1 year
  The occurrence of one or more clinically relevant complication of glucocorticoid therapy during the first year of treatment, according to the Glucocorticoid Toxicity Index (items and specific list).

Trial sites (12)

More University Hospital, Brest trials in France

Other trials for the same condition