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Clinical Trials in France / NCT06414967
Recruiting Not applicable

Study to Evaluate Music Therapy on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD)

NCT06414967 · tracked via the Priya Life Science France tracker
Sponsor
Poitiers University Hospital
Phase
Not applicable
Started
2024-10-15
Last updated
2025-12-29

Condition(s) studied

Huntington Disease

Investigational drug(s) / intervention(s)

Music Intervention

Music Intervention: Music therapy carried out with Music Care

Study summary

The study is an open-label clinical trial evaluating whether music therapy combined with conventional management reduces irritability and impulsivity in 15 patients with early-stage Huntington's disease. This pilot study aims to show the interest of alternative non-pharmacological measures such as a digital music therapy tool, adapted to an audience of Huntington's patients, to help manage the psychobehavioral symptoms frequently observed in this affection, and to avoid breakdowns due to caregiver exhaustion.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age \>= 18 years * Huntington disease genetically confirmed by the presence of at least 35 repeats of the CAG triplet in exon 1 of the HTT gene * UHDRS (Unified Huntington's disease Rating Scale) score \<= 5 with a diagnostic confidence score =4 * Absence of significant cognitive impairment MoCA \>=24 * Stable drug therapy in the 28 days prior inclusion and during the study * Without legal tutors or subordination * Affiliated to a health insurance system as required by the French law on biomedical research * Written informed consent for participation in the study Exclusion Criteria: * Inability to give free and informed consent for study participation * Significant hearing impairment * Participating to another study the day of enrollement * Persons benefiting from enhanced protection, i.e.persons deprived of their liberty by a judicial or administrative decision, adults under legal and finally patients in a vital emergency situation.

Primary outcome measure(s)

  • Describe evolution of irritability in patients with Huntington's disease after 3 months of music therapy combined with conventional management — Month 3
    Score of The brief Irritability Test (BITe). It consists of 5 questions, each rated on likert-type scale with 6 responses options, each question scores to 1 to 6. Lower score means a better outcome.

Trial sites (1)

FacilityCityRegionStatus
CHU Poitiers / CIC Poitiers France Recruiting

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Other trials for the same condition

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GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06414967 on ClinicalTrials.gov ↗ ← All trials in France