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Clinical Trials in France / NCT06626308
Recruiting Not applicable

Early Biomarkers in Premanifest Huntington's Disease Gene Carriers: a Pilot Study

NCT06626308 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Grenoble
Phase
Not applicable
Started
2025-02-20
Last updated
2025-01-20

Condition(s) studied

Huntington Disease

Investigational drug(s) / intervention(s)

brain functional MRI

brain functional MRI: visual protocol stimulation during brain functional MRI

Study summary

The goal of this clinical trial is to investigate if new, early biomarkers of the disease are available in presymptomatic genetic carriers of Huntington\'s diesase compared to healthy subjects. The main questions it aims to answer are:

Does functional brain MRI is able to detect early biomarkers of the disease in genetic carriers? Does gait study by a virtual reality device can detect early biomarkers of the disease in genetic carriers? Researchers will compare genetic carriers and healthy subjects to see if new, early biomarkers of the disease can be detected .

Eligibility

Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
Accepted
Inclusion Criteria: * 1\. For PMGC: HD diagnosis confirmed by genetic testing (CAG triplets ≥36 in HTT gene); Unified Huntington Disease Rating Scale19 Total Motor Score (UHDRS-TMS) ≤ 5; age 18-70 years old. 2. For HC: normal neurological examination; age 18-70 years old. Exclusion Criteria: * Main exclusion criteria for both PMGC and HS will be: major ophthalmologic and psychiatric active diseases; cognitive impairment (Montreal Cognitive Assessment, MoCA score \< 25/30); gait issues related to non-neurological conditions; contraindications to brain MRI.

Primary outcome measure(s)

  • Brain functional MRI biomarker investigation — from the enrollement to the end of the investigation: 2 months
    Measurement of BOLD (Blood Oxygen Level Dependent) signal changes using fMRI (3 Tesla), in two subcortical regions, SC, LGN, and V1 in response to visual stimuli, in PMGC compared to HS.

Trial sites (1)

FacilityCityRegionStatus
Grenoble University Hospital Grenoble France Recruiting

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Other trials for the same condition

A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD Recruiting
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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06626308 on ClinicalTrials.gov ↗ ← All trials in France