Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
NCT03067181 · ClinicalTrials.gov ↗ · Childhood Extracranial Germ Cell Tumor, Extragonadal Embryonal Carcinoma, Germ Cell Tumor
|
Phase 3 |
Recruiting |
Children's Oncology Group |
India, Canada, Mexico, Japan, Australia, Israel |
Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)
NCT03126916 · ClinicalTrials.gov ↗ · Ganglioneuroblastoma, Ganglioneuroblastoma, Nodular, Neuroblastoma
|
Phase 3 |
Recruiting |
Children's Oncology Group |
Canada, Mexico, Israel |
Induction Chemotherapy Followed by Standard Therapy in Cervical Cancer With Aortic Lymph Node Spread
NCT03534713 · ClinicalTrials.gov ↗ · Cervical Cancer TNM Staging Regional Lymph Nodes (N)
|
Phase 3 |
Recruiting |
University Hospital, Toulouse |
France |
Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Patients With Stage I-III Adrenocortical Cancer With High Risk of Recurrence
NCT03583710 · ENSAT Stage I Adrenal Cortex Carcinoma, ENSAT Stage II Adrenal Cortex Carcinoma, ENSAT Stage III Adrenal Cortex Carcinoma
|
Phase 3 |
Recruiting |
M.D. Anderson Cancer Center |
Germany, France, Sweden, Poland |
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
NCT04267848 · ClinicalTrials.gov ↗ · Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma, Lung Non-Squamous Non-Small Cell Carcinoma
|
Phase 3 |
Recruiting |
National Cancer Institute (NCI) |
Norway, Mexico, Israel |
Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL)
NCT04574960 · ClinicalTrials.gov ↗ · Bladder Cancer, Bladder Urothelial Carcinoma
|
Phase 3 |
Recruiting |
University Health Network, Toronto |
Canada |
|
A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss
|
Phase 3 |
Recruiting |
Children's Oncology Group |
Canada, Israel |
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer
NCT05624996 · ClinicalTrials.gov ↗ · Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8
|
Phase 3 |
Recruiting |
NRG Oncology |
Canada, Mexico |
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
NCT06172296 · ClinicalTrials.gov ↗ · Ganglioneuroblastoma, Nodular, Neuroblastoma
|
Phase 3 |
Recruiting |
National Cancer Institute (NCI) |
Canada, Mexico, Australia, Israel |
Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Cancer Confined to the Chest and Previously Operated on Who Were Not Disease-free.
NCT06431633 · ClinicalTrials.gov ↗ · Lung Diseases, Carcinoma, Non-Small-Cell Lung, Resectable Lung Non-Small Cell Carcinoma
|
Phase 3 |
Recruiting |
Fundación GECP |
Spain |
|
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Sweden, Poland, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Singapore, Australia, Israel |
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
NCT07061977 · ClinicalTrials.gov ↗ · Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma, Locally Advanced Cervical Squamous Cell Carcinoma
|
Phase 3 |
Recruiting |
National Cancer Institute (NCI) |
Mexico, Israel |
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study
NCT07097142 · ClinicalTrials.gov ↗ · Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8, Stage IIIA Bladder Cancer AJCC v8
|
Phase 3 |
Recruiting |
NRG Oncology |
Canada |
|
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
UK, USA, China, France, Spain, Italy, Netherlands, Belgium, Poland, Switzerland, Austria, Turkey, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Australia, Israel |
|
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
|
Phase 3 |
Recruiting |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, India, Germany, France, Spain, Italy, Belgium, Sweden, Denmark, Poland, Austria, Czechia, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Israel |
Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer
NCT04628767 · ClinicalTrials.gov ↗ · Renal Pelvis and Ureter Urothelial Carcinoma
|
Phase 2/3 |
Recruiting |
National Cancer Institute (NCI) |
Mexico |
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
NCT02734537 · ClinicalTrials.gov ↗ · Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma, Laryngeal Squamous Cell Carcinoma
|
Phase 2 |
Recruiting |
ECOG-ACRIN Cancer Research Group |
Mexico |
Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma
NCT04671667 · ClinicalTrials.gov ↗ · Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma
|
Phase 2 |
Recruiting |
National Cancer Institute (NCI) |
Mexico |
Using ctDNA to Determine Therapies for Lung Cancer
NCT04966663 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, Complete Surgical Resection, Circulating Tumor DNA
|
Phase 2 |
Recruiting |
University Health Network, Toronto |
Canada |
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
NCT05489211 · Endometrial Cancer, Gastric Cancer, Metastatic Castration-resistant Prostate Cancer
|
Phase 2 |
Recruiting |
AstraZeneca |
UK, USA, China, Germany, France, Spain, Italy, Poland, Switzerland, Turkey, Canada, Japan, South Korea, Taiwan |
Y-90 With Durvalumab/Gem/Cis in Intrahepatic Cholangio
NCT05655949 · ClinicalTrials.gov ↗ · Bile Duct Cancer, Cholangiocarcinoma, Cholangiocarcinoma Non-resectable
|
Phase 2 |
Recruiting |
Beth Israel Deaconess Medical Center |
Israel |
Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer
NCT06029270 · ClinicalTrials.gov ↗ · Metastatic Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma, Stage IV Nasopharyngeal Carcinoma AJCC v8
|
Phase 2 |
Recruiting |
National Cancer Institute (NCI) |
Canada, Singapore, Australia |
A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)
NCT06064097 · ClinicalTrials.gov ↗ · Stage II Nasopharyngeal Carcinoma AJCC v8, Stage III Nasopharyngeal Carcinoma AJCC v8, Stage IV Nasopharyngeal Carcinoma AJCC v8
|
Phase 2 |
Recruiting |
National Cancer Institute (NCI) |
Canada, Australia, Israel |
Study to Evaluate the Safety and Efficacy of Daratumumab and Carfilzomib-based Induction/Consolidation/Maintenance Therapy in Transplant-eligible, Ultra High-risk, Newly Diagnosed Multiple Myeloma
NCT06140966 · ClinicalTrials.gov ↗ · Multiple Myeloma, Primary Plasma Cell Leukemia, Extramedullary Multiple Myeloma
|
Phase 2 |
Recruiting |
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
China |
Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer
NCT06532279 · ClinicalTrials.gov ↗ · Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
|
Phase 2 |
Recruiting |
NRG Oncology |
Mexico |
Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial
NCT06770582 · ClinicalTrials.gov ↗ · Non-Muscle Invasive Bladder Urothelial Carcinoma, Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma, Stage I Bladder Cancer AJCC v8
|
Phase 2 |
Recruiting |
National Cancer Institute (NCI) |
Canada |
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
NCT06428409 · Colorectal Cancer, Pancreatic Ductal Adenocarcinoma, Biliary Tract Cancer
|
Phase 1/2 |
Recruiting |
Merck Sharp & Dohme LLC |
UK, USA, China, Spain, Italy, Switzerland, Turkey, Canada, Japan, South Korea, Taiwan, Australia |
A Randomised Trial of Chemotherapy Plus Surgery for Recurrent Non-Small Cell Lung Cancer
NCT02889666 · ClinicalTrials.gov ↗ · Recurrent Non-small Cell Lung Cancer
|
Phase 1 |
Recruiting |
Shanghai Jiao Tong University School of Medicine |
China, Japan |
Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer
NCT05172245 · ClinicalTrials.gov ↗ · Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Head and Neck Carcinoma of Unknown Primary
|
Phase 1 |
Recruiting |
National Cancer Institute (NCI) |
Canada |
Pathological Response After Neoadjuvant Treatment on NSCLC
NCT05167487 · ClinicalTrials.gov ↗ · Stage IIIA Non-small Cell Lung Cancer
|
Observational |
Recruiting |
Fundación GECP |
Spain |
Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
NCT00588770 · ClinicalTrials.gov ↗ · Neck Squamous Cell Carcinoma of Unknown Primary, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Mexico, Israel |
Platinum in Treating Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy
NCT02445391 · ClinicalTrials.gov ↗ · Estrogen Receptor Negative, HER2/Neu Negative, Invasive Breast Carcinoma
|
Phase 3 |
Active, closed |
ECOG-ACRIN Cancer Research Group |
Mexico, Israel |
Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers
NCT02466971 · ClinicalTrials.gov ↗ · Advanced Vaginal Adenocarcinoma, Advanced Vaginal Adenosquamous Carcinoma, Advanced Vaginal Squamous Cell Carcinoma
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Canada, Mexico |
|
Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China, Germany, France, Spain, Italy, Belgium, Poland, Canada, Brazil, Japan, South Korea, Taiwan, Australia, Egypt |
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery
NCT03533582 · ClinicalTrials.gov ↗ · Childhood Hepatocellular Carcinoma, Childhood Malignant Liver Neoplasm, Fibrolamellar Carcinoma
|
Phase 3 |
Active, closed |
Children's Oncology Group |
Canada, Mexico, Australia, Israel |
|
Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, Germany, France, Spain, Belgium, Poland, Switzerland, Austria, Portugal, Canada, Brazil, Mexico, Japan, South Korea, Taiwan, Australia, Israel |
Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer
NCT03775265 · ClinicalTrials.gov ↗ · Bladder Urothelial Carcinoma, Muscle Invasive Bladder Carcinoma, Stage II Bladder Cancer AJCC v8
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Norway |
Testing the Addition of a New Immunotherapy Drug, Atezolizumab (MPDL3280A), to the Usual Chemoradiation (CRT) Therapy Treatment for Limited Stage Small Cell Lung Cancer (LS-SCLC)
NCT03811002 · ClinicalTrials.gov ↗ · Limited Stage Lung Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Norway, Mexico, Japan, Egypt |
Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer
NCT03811015 · ClinicalTrials.gov ↗ · Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Mexico, Egypt |
Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer
NCT04092283 · ClinicalTrials.gov ↗ · Recurrent Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8
|
Phase 3 |
Active, closed |
National Cancer Institute (NCI) |
Mexico, Israel |
|
CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)
|
Phase 3 |
Active, closed |
University of Birmingham |
Ireland |
Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)
NCT04380636 · Lung Neoplasms, Carcinoma, Non-Small-Cell Lung
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
UK, USA, China, Germany, France, Spain, Italy, Poland, Czechia, Norway, Turkey, Canada, Mexico, Japan, South Korea |
Sacituzumab Govitecan in Primary HER2-negative Breast Cancer
NCT04595565 · HER2-negative Breast Cancer, Triple Negative Breast Cancer
|
Phase 3 |
Active, closed |
GBG Forschungs GmbH |
Ireland, Germany, France, Spain, Belgium, Switzerland, Austria |
|
Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
UK, USA, China, Germany, France, Spain, Italy, Belgium, Sweden, Denmark, Poland, Austria, Czechia, Norway, Turkey, Canada, Mexico, Japan, South Korea, Taiwan, Israel |
|
Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
UK, USA, China, Germany, France, Spain, Italy, Poland, Czechia, Portugal, Canada, Japan, South Korea, Taiwan, Singapore, Australia, Israel |
|
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China, Germany, Spain, Italy, Netherlands, Belgium, Sweden, Denmark, Poland, Czechia, Norway, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia, Israel |
|
Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
Ireland, UK, USA, China, Germany, France, Spain, Italy, Netherlands, Poland, Austria, Portugal, Turkey, Canada, Mexico, Japan, South Korea, Australia, Israel |
|
A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
USA, China, France, Spain, Poland, Turkey, Brazil, Japan, Taiwan |
|
MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
|
Phase 3 |
Active, closed |
AstraZeneca |
UK, USA, China, Germany, France, Spain, Italy, Netherlands, Belgium, Denmark, Poland, Switzerland, Norway, Turkey, Canada, Brazil, Japan, South Korea, Taiwan, Australia |
A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)-Japan Extension
NCT06212752 · ClinicalTrials.gov ↗ · Metastatic Non-small Cell Lung Cancer
|
Phase 3 |
Active, closed |
Merck Sharp & Dohme LLC |
Japan |
A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin Lymphoma
NCT06230224 · ClinicalTrials.gov ↗ · B-Cell Non-Hodgkin Lymphoma (B-NHL)
|
Phase 3 |
Active, closed |
Regeneron Pharmaceuticals |
Spain, Turkey, Brazil, South Korea, Taiwan, Singapore, Australia |
Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
NCT02135042 · ClinicalTrials.gov ↗ · EBV Infection, Stage II Nasopharyngeal Carcinoma AJCC v7, Stage III Nasopharyngeal Carcinoma AJCC v7
|
Phase 2/3 |
Active, closed |
NRG Oncology |
China, Canada, Taiwan, Singapore, Australia |
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer
NCT03952585 · Basaloid Squamous Cell Carcinoma, Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
|
Phase 2/3 |
Active, closed |
National Cancer Institute (NCI) |
Canada, Mexico |
Comparison of Chemotherapy Before and After Surgery Versus After Surgery Alone for the Treatment of Gallbladder Cancer
NCT04559139 · ClinicalTrials.gov ↗ · Stage II Gallbladder Cancer AJCC v8, Stage IIA Gallbladder Cancer AJCC v8, Stage IIB Gallbladder Cancer AJCC v8
|
Phase 2/3 |
Active, closed |
ECOG-ACRIN Cancer Research Group |
Mexico, Israel |
Comparing Cisplatin Every Three Weeks to Cisplatin Weekly When Combined With Radiation for Patients With Advanced Head and Neck Cancer
NCT05050162 · Advanced Head and Neck Squamous Cell Carcinoma, Advanced Hypopharyngeal Squamous Cell Carcinoma, Advanced Laryngeal Squamous Cell Carcinoma
|
Phase 2/3 |
Active, closed |
NRG Oncology |
Ireland, Switzerland, Canada, Mexico |
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers
NCT05063552 · ClinicalTrials.gov ↗ · Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma
|
Phase 2/3 |
Active, closed |
National Cancer Institute (NCI) |
Mexico |
|
A Trial to Learn How the Combination of Fianlimab With Cemiplimab and Chemotherapy Works Compared With Cemiplimab and Chemotherapy for Treating Adult Patients With Advanced Non-small Cell Lung Cancer
|
Phase 2/3 |
Active, closed |
Regeneron Pharmaceuticals |
USA, Turkey, Canada, Mexico, South Korea, Taiwan, Australia, Israel |
Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer
NCT01585805 · ClinicalTrials.gov ↗ · Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8
|
Phase 2 |
Active, closed |
National Cancer Institute (NCI) |
Canada, Israel |
Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer
NCT01898494 · ClinicalTrials.gov ↗ · Human Papilloma Virus Infection, Stage III Squamous Cell Carcinoma of the Oropharynx, Stage IVA Squamous Cell Carcinoma of the Oropharynx
|
Phase 2 |
Active, closed |
ECOG-ACRIN Cancer Research Group |
Mexico |
A Study of Different Dosing Schedules of Selumetinib With Cisplatin/Gemcitabine (CIS/GEM) Versus CIS/GEM Alone in Biliary Cancer
NCT02151084 · ClinicalTrials.gov ↗ · Biliary Tract Carcinoma, Gallbladder Carcinoma
|
Phase 2 |
Active, closed |
University Health Network, Toronto |
Canada |
Cisplatin and Etoposide Versus Temozolomide and Capecitabine in Patients With Advanced Poorly Differentiated (G3) Non-Small Cell Gastrointestinal Neuroendocrine Carcinomas
NCT02595424 · ClinicalTrials.gov ↗ · Gastric Neuroendocrine Carcinoma, Intestinal Neuroendocrine Carcinoma, Pancreatic Neuroendocrine Carcinoma
|
Phase 2 |
Active, closed |
ECOG-ACRIN Cancer Research Group |
Mexico, Israel |
|
Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma
|
Phase 2 |
Active, closed |
Children's Oncology Group |
Canada, Australia, Israel |
A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, INSPIRE Trial
NCT04216290 · ClinicalTrials.gov ↗ · Bladder Urothelial Carcinoma, Stage III Bladder Cancer AJCC v8
|
Phase 2 |
Active, closed |
National Cancer Institute (NCI) |
Mexico |
Cisplatin+Pembrolizumab+RT in Vulvar Cancer
NCT04430699 · ClinicalTrials.gov ↗ · Vulvar Cancer, Vulvar Squamous Cell Carcinoma
|
Phase 2 |
Active, closed |
Massachusetts General Hospital |
Israel |
|
Intravesical Recombinant BCG Followed by Perioperative Chemo-immunotherapy for Patients With MIBC
|
Phase 2 |
Active, closed |
Swiss Cancer Institute |
Switzerland |
Nivolumab and Ipilimumab Plus Chemotherapy for Patients With Stage IV Lung Cancer With Brain Metastases
NCT05012254 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, Brain Metastases, Adult, Lung Cancer
|
Phase 2 |
Active, closed |
Fundación GECP |
Spain |
|
Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)
|
Phase 2 |
Active, closed |
Gilead Sciences |
UK, USA, Germany, France, Spain, Italy, Canada, South Korea, Taiwan, Australia |
Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer
NCT05198830 · ClinicalTrials.gov ↗ · Lung Adenocarcinoma, Lung Large Cell Carcinoma, Lung Non-Squamous Non-Small Cell Carcinoma
|
Phase 2 |
Active, closed |
National Cancer Institute (NCI) |
Israel |
Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors
NCT05945823 · Locally Advanced Unresectable or Metastatic Solid Tumors Including Esophageal Cancer, Esophageal Adenocarcinoma, Esophageal Squamous Cell Cancer
|
Phase 2 |
Active, closed |
Taiho Oncology, Inc |
USA, Germany, France, Spain |
|
A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery
|
Phase 2 |
Active, closed |
Regeneron Pharmaceuticals |
USA, Germany, France, Spain, Italy, Turkey, South Korea, Taiwan, Australia |
|
Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)
|
Phase 2 |
Active, closed |
Merck Sharp & Dohme LLC |
USA, Spain, Italy, Poland, Turkey |
Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer
NCT04491942 · ClinicalTrials.gov ↗ · Advanced Bile Duct Carcinoma, Advanced Breast Carcinoma, Advanced Cervical Carcinoma
|
Phase 1 |
Active, closed |
National Cancer Institute (NCI) |
Canada |
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)
NCT02194738 · ClinicalTrials.gov ↗ · Stage IB Lung Non-Small Cell Carcinoma AJCC v7, Stage II Lung Non-Small Cell Cancer AJCC v7, Stage IIA Lung Cancer AJCC v8
|
Not applicable |
Active, closed |
National Cancer Institute (NCI) |
Norway, Mexico, Israel |