Clinical Trials in France / NCT04934007
Recruiting
Not applicable
Bilateral Lateral OFC rTMS in Obsessive Compulsive Disorder
NCT04934007 · tracked via the Priya Life Science France tracker
Condition(s) studied
Obsessive-Compulsive Disorder
Investigational drug(s) / intervention(s)
rTMS Treatment
rTMS Treatment: 1 Hz rTMS
Study summary
According to the literature the lateral part of the Orbito Frontal Cortex (lOFC) is a relevant bilateral target for repetitive Trans-cranial Magnetic Stimulation (rTMS) in Obsessive Compulsive Disorder (OCD). Both hemispheres are concerned in terms of target.
Eligibility
Inclusion Criteria:
* Age: Participants will be both males and females, 18-65 years of age included.
* diagnosis of OCD
* all the patients must have failed to respond to at least two different pharmacological treatment used for at least 6 weeks
* Affiliation to a social security system (recipient or assignee),
* Signed written inform consent form
Exclusion Criteria:
* The exclusion criteria are a diagnosis of another psychiatric disorder (except for anxious disorders), a diagnosis of a significant active medical illness, pregnancy or other neurological illness
* In accordance with the safety criteria for rTMS, patients with a history of seizure or bearing pacemakers, mobile metal implants, implanted medical pumps, or metal clips placed inside the skull will also be excluded
* The patients won't be allowed to change their medication during the trial. The treatment must be stable at least 3 week before day 0.
* Female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception or who is nursing,
* Patient under curators
* Patient hospitalized under duress
* Patient unable to give his or hers informed consent
Primary outcome measure(s)
- Yale Brown Obsessive Compulsive Scale score — baseline and 25 days
Significant clinical change (≥ 25%) from baseline to two weeks after the treatment sequence, assessed by a significant reduction in YBOCS scores at day 25
Trial sites (2)
| Facility | City | Region | Status |
|---|---|---|---|
| Sorbonne University, Pitié-Salpêtrière Hospital | Paris | France | Recruiting |
| Centre Hospitalier Henri Laborit | Poitiers | France | Recruiting |
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Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT04934007 on ClinicalTrials.gov ↗ ← All trials in France