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Clinical Trials in France / NCT06780722
Recruiting Observational

Study of the Occurrence of Cardiocirculatory Arrest as a Function of the Level of Hypoxemia During a Maastricht 3 Procedure

NCT06780722 · tracked via the Priya Life Science France tracker
Sponsor
Nantes University Hospital
Phase
Observational
Started
2025-12-19
Last updated
2026-06-25

Condition(s) studied

Cardiac ArrestReanimation

Investigational drug(s) / intervention(s)

blood sampling

blood sampling: * The first sample is taken at the start of the therapeutic stop. * The second sample is taken when the mean arterial pressure drops to 45mmHg. * The third sample is taken when circulatory arrest occurs. * The fourth sample is taken at the start of extracorporeal circulation. These four samples will be destroyed at the end of the study.

Study summary

Evaluation of the level of hypoxemia during the occurrence of cardiocirculatory arrest during a Maastricht III organ donation procedure.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
FOR THE DONORS : Inclusion Criteria : * Patient over 18 years of age * Organ donation procedure initiated in accordance with the legislation and procedures in force in France for the Maastricht III category * No opposition formulated by the relative to the patient's participation in the study Exclusion Criteria : * Patient registered on the national register of refusals or living refusal of donation * Pregnant or breast-feeding women * Patients under guardianship, curatorship or legal protection * Medical contraindication to organ donation according to the recommendations of the Agence de Biomédecine currently in force in France FOR THE RECEIVER Inclusion Criteria : * No opposition to the collection of data concerning him/her * Patient over 18 at pre-transplant consultation * Patient who has received an organ from a donor participating in the HEPHAISTOS protocol Exclusion Criteria : \- Patients under guardianship, curatorship or legal protection

Primary outcome measure(s)

  • PaO2 level — 24 hours
    PaO2 level and its 95% confidence interval in the event of circulatory cardiac arrest, defined as a pulse pressure below 5 mmHg, during a Maastricht III procedure.

Trial sites (12)

FacilityCityRegionStatus
CHU ANGERS - Réanimation médicale Angers France Recruiting
CH ANNECY GENEVOIS - Réanimation médicale - Coordination Prélèvements multi-organes Annecy France Recruiting
CH AVIGNON - CH Henri Duffaut - Réanimation polyvalente Avignon France Recruiting
CHD Vendée - Les Oudairies - Médecine Intensive Réanimation La Roche-sur-Yon France Recruiting
CHU LILLE - Hôpital Roger Salengro - Médecine Intensive Réanimation Lille France Recruiting
CHU de Nantes - Hôpital Laennec Nantes France Recruiting
CHU NANTES +- Médecine Intensive Réanimation Nantes France Recruiting
CHRU ORLEANS -Médecine Intensive Réanimation - Coordination Prélèvements multi-organes Orléans France Recruiting
CHU POITIERS - Anesthésie Réanimation - Coordination Prélèvements multi-organes Poitiers France Not Yet Recruiting
CHU RENNES - CHU Pontchaillou - Réanimation médicale Rennes France Recruiting
CHRU TOURS - Hôpital Bretonneau - Médecine Intensive Réanimation Tours France Recruiting
CHBA Vannes-Auray - Réanimation Polyvalente Vannes France Recruiting

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Other trials for the same condition

Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest Recruiting
Heart Rate Variability in Early Prediction of a Noxic Brain Injury After Cardiac Arrest Recruiting
Versailles Hospital Cardiac Arrest Registry Recruiting
Mean Arterial Pressure After Out-of-hospital Cardiac Arrest Recruiting
Early and Objective Assessment of Neurological Prognosis in Cardiac Arrest Patients Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06780722 on ClinicalTrials.gov ↗ ← All trials in France