Clinical trial register · China

Clinical Trials in China

Every study on the ClinicalTrials.gov registry that lists a site in China and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 19187 matching records held by the registry are in this view. Synced 07 Nov 2026, 03:17 UTC

19187

Studies in scope

all four open statuses

11790

Recruiting now

open to new participants

2028

Lead sponsors

across recruiting studies

Top sites

Beijing 5576 Shanghai 3879 Guangzhou 3345 Hangzhou 1819 Wuhan 1343

Trials in this register

Status

Study

Lead sponsor

Phase

Enrol

Chinese sites

Start

Recruiting

Omega-3 Fatty Acids, Neuroendocrine and Attention Deficit Hyperactivity Disorder (OMNeADHD)

NCT07364331ADHD, Children, Adolescents

China Medical University Hospital

Not applicable

100

2021-09-04

Recruiting

Drug Sensitivity Detection of Micro Tumor (PTC) to Guide Postoperative Adjuvant Treatment Strategy of Colorectal Cancer

NCT05424692Colon Cancer, Rectal Cancer, Chemotherapy Effect, PTC

DrugAdrucil

Peking Union Medical College Hospital

Not applicable

200

Beijing

2021-09-01

Recruiting

A Registered Cohort Study on Neurodegenerative Associated With Sleep Disorder.

NCT05524922Neurodegenerative Disorder

Fujian Medical University Union Hospital

Observational

500

Fuzhou

2021-09-01

Recruiting

A Registered Cohort Study on α-Synucleinopathy

NCT05527067α-synucleinopathy

Fujian Medical University Union Hospital

Observational

500

Fuzhou

2021-09-01

Active, closed

A Clinical Effectiveness Study of Total Laparoscopic Subcutaneous Gland Resection Combined With Nipple-Areola Complex Lift in the Management of Moderate to Severe Gynecomastia in Males

NCT07314086Gynecomastia

First Affiliated Hospital of Harbin Medical University

Observational

200

Harbin

2021-09-01

Recruiting

Light Therapy in Parkinson's Disease

NCT06129942Parkinson Disease, Sleep Disorder, Circadian Rhythm Disorders

Second Affiliated Hospital of Soochow University

Not applicable

Suzhou

2021-09-01

Recruiting

The Research About the ACS After Femoropopliteal Arterial Injuries

NCT05030259Acute Compartment Syndrome

Hebei Medical University Third Hospital

Observational

Shijiazhuang

2021-09-01

Recruiting

Effect of Sacubitril/Valsartan on Cardiac Function in Hypertensive Patients Stratified by BMI: A Real World Study

NCT05498675Sacubitril/Valsartan, Hypertension, Obesity

DrugsACEI/ARB·Sacubitril / Valsartan

Beijing Friendship Hospital

Observational

180

Beijing

2021-09-01

Recruiting

Cervical Cancer Screening with NGS-HPV Technology Based on Menstrual Blood

NCT06082765Cervical Cancer

Zhongnan Hospital

Observational

10,000

Wuhan

2021-09-01

Active, closed

Camrelizumab Plus Neoadjuvant Chemotherapy or Chemoradiotherapy Versus Chemoradiotherapy in Resectable ESCC.

NCT05043688Resectable Esophageal Squamous Cell Carcinoma

DrugCamrelizumab

Zhigang Li

Phase 3

426

Shanghai, Anyang, Guangzhou, Hefei

2021-09-01

Recruiting

Neoadjuvant Personalized Anti-PD-1 and Anti-VEGFR Therapy in OSCC Patients

NCT05069857Oral Squamous Cell Carcinoma, Neoadjvant Therapy, Anti-PD-1, Anti-VEGFR

DrugsApatinib·Camrelizumab

Shanghai Jiao Tong University School of Medicine

Phase 2

Shanghai

2021-09-01

Active, closed

Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC

NCT04919811Non Small Cell Lung Cancer

DrugTaletrectinib

Nuvation Bio Inc.

Phase 2

217

Beijing, Zhengzhou, Shanghai, Changsha, Chengdu, Jinan, Wuhan

2021-09-01

Recruiting

Butylphthalide's Safety and Efficacy for Improving Neurological Function Prognosis in Patients With Cardiac Arrest (BNCA Trial)

NCT06353334Butylphthalide, Cardiac Arrest, Neuroprotective Drugs

DrugButylphthalide and Sodium Chloride

Tang Ziren

Phase 4

100

Beijing

2021-09-01

Recruiting

CtDNA as a Novel Biomarker of Treatment Efficacy in Patients With Ovarian Cancer

NCT05027828High-grade Serous Ovarian Cancer, Circulating Tumor DNA

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Observational

100

Shanghai

2021-09-01

Recruiting

Patient-derived Tumor-like Cell Clusters Predict Progesterone Sensitivity in Patients With Early Endometrial Cancer

NCT05647109Endometrial Carcinoma Stage I, Atypical Endometrial Hyperplasia

Peking University People's Hospital

Observational

244

Beijing

2021-09-01

Recruiting

S-1 and Oxaliplatin (SOX) Plus Sintilimab in the Locally Advanced Esophagogastric Junction Adenocarcinoma

NCT04989985Locally Advanced Gastroesophageal Junction Adenocarcinoma, Chemotherapy Effect

DrugsSinitilimab·Teysuno·Oxaliplatin

Sixth Affiliated Hospital, Sun Yat-sen University

Phase 2

302

Guangzhou

2021-09-01

Recruiting

Bespoke ctDNA Assay for Recurrence and Treatment Response Monitoring in Advanced Epithelial Ovarian Cancer

NCT05446545Ovarian Cancer

Fudan University

Observational

139

Shanghai

2021-09-01

Active, closed

Clinical Study for Treatment-naïve IOPD Babies to Evaluate Efficacy and Safety of ERT With Avalglucosidase Alfa

NCT04910776Glycogen Storage Disease Type II

DrugAvalglucosidase alfa

Sanofi

Phase 3

Qingdao, Shanghai

2021-09-01

Recruiting

18F-MFBG PET/CT in the Evaluation of Neural Crest Tumor

NCT05069220Neuroendocrine Tumor, Neuroblastoma, Pheochromocytoma, Paraganglioma

Drugs68Ga-DOTATATE·18F-MFBG

Peking Union Medical College Hospital

Early Phase 1

150

Beijing

2021-09-01

Recruiting

MRD Monitoring in Lung Cancer After Resection

NCT04976296Lung Cancer

Guangdong Provincial People's Hospital

Observational

300

Guangzhou

2021-09-01

Recruiting

Avatrombopag in the Treatment of Adult Immune Thrombocytopenia With Autoantibodies

NCT04993885Immune Thrombocytopenia, Autoantibodies, Evan Syndrome, Connective Tissue Diseases

DrugAvatrombopag

Institute of Hematology & Blood Diseases Hospital, China

Phase 2

Tianjin

2021-09-01

Active, closed

New Double Epigenetic Regimen in the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

NCT05029141Acute Myeloid Leukemia, Refractory Acute Leukemia, Relapsed Adult AML

The First Affiliated Hospital of Soochow University

Phase 2

Suzhou

2021-09-01

Active, closed

An Observational Study on Post-chronic Pancreatitis Diabetes Mellitus

NCT05764629Chronic Pancreatitis, Diabetes Mellitus

Changhai Hospital

Observational

324

Shanghai

2021-09-01

Not yet open

Optimized Antiplatelet Therapy in Patients With CHD After Implantation of NeoVas™ BRS System

NCT04995159Coronary Heart Disease

Lepu Medical Technology (Beijing) Co., Ltd.

Not applicable

2,150

Bengbu, Hefei, Wuhu, Beijing, Chongqing, Lanzhou, Foshan, Guangzhou

2021-09

Not yet open

Dragon III-Phase 3: Neoadjuvant Chemotherapy (FLOT Versus SOX) for Gastric Cancer

NCT04384601Gastric Cancer, Neoadjuvant Chemotherapy

Ruijin Hospital

Phase 3

246

Shanghai

2021-09

Active, closed

A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK043 in Patients With Advanced Solid Tumor

NCT04964375Neoplasms

DrugABSK043

Abbisko Therapeutics Co, Ltd

Phase 1

102

Chongqing, Fuzhou, Ganzhou, Hangzhou, Harbin, Hefei, Mianyang, Nanjing

2021-08-31

Recruiting

China Type II Inflammatory Skin Disease Clinical Research and Standardized Diagnosis and Treatment Project

NCT05316805Atopic Dermatitis Eczema, Prurigo Nodularis

Peking University First Hospital

Observational

100,000

Beijing

2021-08-31

Recruiting

SKLB1028, Daunorubicin, and Cytarabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)

NCT05445154Newly Diagnosed Acute Myeloid Leukemia (AML)

CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Phase 1/2

Chengdu

2021-08-31

Recruiting

Precise Diagnosis, Treatment and Prognostic Evaluation of Complicated Adrenal Tumor Diseases

NCT04529629Complicated Adrenal Tumor Diseases

Shanghai Jiao Tong University School of Medicine

Observational

1,000

Shanghai

2021-08-30

Active, closed

PRL3-Zumab in Patients With Advanced Solid Tumors

NCT07541001Advanced Malignant Solid Tumor

DrugPRL3-ZUMAB

Intra-IMMUSG Pte Ltd

Phase 2

Hangzhou

2021-08-30

Recruiting

R-CDOP Regimen in the Treatment of Newly Diagnosed Non-Hodgkin's Lymphoma With High Tumor Burden

NCT05040555Diffuse Large B Cell Lymphoma, Follicular Lymphoma Grade 3B

oubai, MD/PhD

Not applicable

Changchun

2021-08-30

Active, closed

To Evaluate the Efficacy and Safety of SHR0302 Tablet in Subjects of Active Psoriatic Arthritis

NCT04957550Psoriatic Arthritis

Jiangsu HengRui Medicine Co., Ltd.

Phase 3

418

Beijing

2021-08-30

Active, closed

Oncogenetic Panel and Integrated Clinical Data Registry Study for Wild Type Gastrointestinal Stromal Tumor Patients

NCT04821895Gastrointestinal Stromal Tumor (GIST)

National Health Research Institutes, Taiwan

Observational

2021-08-28

Active, closed

A Study of AK104 Plus Platinum-containing Chemotherapy±Bevacizumab as First-line Treatment for Persistent, Recurrent, or Metastatic Cervical Cancer

NCT04982237Cervical Cancer

DrugsCadonilimab·Paclitaxel·Bevacizumab·Cisplatin

Akeso

Phase 3

445

Hangzhou, Hefei, Shanghai

2021-08-27

Active, closed

A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)

NCT04961996Early Breast Cancer

DrugGiredestrant

Hoffmann-La Roche

Phase 3

4,170

Zhengzhou, Changsha, Nanchang, Changchun, Shanghai, Chengdu, Hangzhou, Beijing

2021-08-27

Recruiting

Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer

NCT05201430Rectal Cancer

DrugsFolfoxiri·Capeox·Irinotecan·Adrucil

Fudan University

Phase 3

300

Shanghai

2021-08-27

Recruiting

Application of CT-Linac-Based "All-in-One" One-Stop Radiotherapy in Breast Cancer

NCT07776301Breast Cancer

Fudan University

Not applicable

225

Shanghai

2021-08-27

Active, closed

Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/III Rectal Cancer

NCT04922853Rectal Cancer, Neoadjuvant Chemotherapy

West China Hospital

Phase 3

554

Wuxi, Chengdu, Kunming

2021-08-26

Recruiting

Safety Surveillance of Targeted Drugs for Pulmonary Hypertension Using a Computerized Follow-up System: a Nationwide Cohort Study

NCT05372263Pulmonary Hypertension

China National Center for Cardiovascular Diseases

Observational

700

Beijing

2021-08-26

Recruiting

Lenvatinib Plus Sintilimab in Patients With Immune Checkpoint Inhibitor Previously Treated Advanced Liver Cancer

NCT05010681Intrahepatic Cholangiocarcinoma

DrugsSintilimab·Lenvatinib

Fudan University

Phase 2

Shanghai

2021-08-24

Active, closed

Anlotinib Combined With Carboplatin/Paclitaxel as First-line Treatment in Patients With Advanced Ovarian Cancer

NCT04807166Ovarian Neoplasms, Fallopian Tube Neoplasms, Neoplasms by Site, Genital Neoplasms, Female

DrugsCarboplatin/Paclitaxel·Anlotinib

Wenjun Cheng

Phase 2

Huai'an, Nanjing, Suzhou, Wuxi, Yancheng

2021-08-24

Recruiting

A Study of AK109 and AK104 in Advanced Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma

NCT04982276Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma

DrugsPulocimab·Cadonilimab·Paclitaxel

Akeso

Phase 1/2

138

Beijing

2021-08-23

Active, closed

A Multicenter Randomized Open-label Study of Diammonium Glycyrrhizinate Enteric-coated Capsule Plus DXM Versus DXM in Treatment of ITP

NCT05023915Immune Thrombocytopenia

DrugDexamethasone

Shandong University

Phase 2

106

Jinan, Qingdao

2021-08-21

Recruiting

Efficacy and Safety of Duloxetine in Chinese Solid Tumor Patients With Taxanes-induced Painful Peripheral Neuropathy

NCT04970121Chemotherapy-induced Peripheral Neuropathy, Pain, Solid Tumor

DrugDuloxetine

Yan Yang, MD, Ph.D

Phase 2

100

Bengbu

2021-08-21

Active, closed

A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )

NCT04849728NASH - Nonalcoholic Steatohepatitis

Inventiva Pharma

Phase 3

1,000

Hefei, Beijing, Chongqing, Fuzhou, Lanzhou, Guangzhou, Shenzhen, Nanning

2021-08-19

Active, closed

Multi-centre Study to Evaluate ACAF Versus Laminoplasty in Treating Cervical Ossification of the Posterior Longitudinal Ligament

NCT04968028Ossification of Posterior Longitudinal Ligament, Cervical Spondylosis With Myelopathy

Shanghai Changzheng Hospital

Not applicable

167

Beijing, Shenzhen, Harbin, Jining, Qingdao, Shanghai, Taiyuan, Xi’an

2021-08-17

Recruiting

Effect of Standard Nutrition Therapy on Nutritional Status and Prognosis in Locoregionally Advanced Nasopharyngeal Carcinoma Patients With Malnutrition

NCT04436965Nasopharyngeal Carcinoma, Nutrition Therapy

DrugCisplatin

Sun Yat-sen University

Phase 3

266

Guangzhou

2021-08-16

Active, closed

A Study of Penpulimab (AK105) in the First-line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma

NCT04974398Nasopharyngeal Carcinoma

DrugsPenpulimab·Cisplatin/Carboplatin·Gemcitabine

Akeso

Phase 3

296

Hefei, Fuzhou, Xiamen, Dongguan, Guangzhou, Jiangmen, Shantou, Shenzhen

2021-08-16

By invitation

Selatogrel Outcome Study in Suspected Acute Myocardial Infarction

NCT04957719Acute Myocardial Infarction

Viatris Innovation GmbH

Phase 3

25,000

Baotou, Beijing, Cangzhou, Changchun, Changsha, Chaoyang District, Chengdu, Chongqing

2021-08-14

Active, closed

A Trial of AK117 (Anti-CD47 Antibody) in Patients With Acute Myeloid Leukemia

NCT04980885Acute Myeloid Leukemia

DrugsLigufalimab·Azacitidine

Akeso

Phase 1/2

Hangzhou

2021-08-13

Recruiting

Neoadjuvant Osimertinib + Chemotherapy for EGFR-mutant Stage III NSCLC

NCT05011487Non-Small Cell Lung Cancer

DrugsTagrisso·Osimertinib·Pemetrexed·Cisplatin

Sun Yat-sen University

Phase 2

Guangzhou

2021-08-13

Active, closed

Effectivity and Safety of PFO Closure vs Medicine in Alleviating Migraine

NCT04946734PFO - Patent Foramen Ovale, Migraine

DrugsAspirin and clopidogrel·Triptans

Guangdong Provincial People's Hospital

Phase 3

440

Xiamen, Guangzhou, Huizhou, Jiangmen, Shenzhen, Zhanjiang, Nanning, Shangqiu

2021-08-12

Recruiting

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

NCT04924075Pheochromocytoma/Paraganglioma, Pancreatic Neuroendocrine Tumor, Von Hippel-Lindau Disease, Advanced Gastrointestinal Stromal Tumor

DrugBelzutifan

Merck Sharp & Dohme LLC

Phase 2

355

Beijing, Guangzhou, Shanghai, Chengdu

2021-08-12

Active, closed

Aumolertinib with or Without Chemotherapy As 1st Line Treatment in Locally Advanced or Metastatic Non-Small Cell Lung Cancer with Sensitizing EGFR Mutations

NCT04923906Non-small Cell Lung Cancer

DrugAlmonertinib

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Phase 3

624

Shanghai

2021-08-11

Recruiting

Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline

NCT05014893Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Aging, Healthy

National Research Center for Rehabilitation Technical Aids

Not applicable

100

Beijing

2021-08-06

Recruiting

ENVAFOLIMAB Single-agent Treatment in Patients With Advanced Solid Tumors

NCT04891198Solid Tumor

DrugEnvafolimab

3D Medicines (Sichuan) Co., Ltd.

Phase 2

126

Beijing

2021-08-06

By invitation

IT Matters: The Erectile Restoration Registry

NCT04200937Erectile Dysfunction

Boston Scientific Corporation

Observational

450

Beijing, Shanghai

2021-08-05

Recruiting

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

NCT04913285Solid Tumor, Adult, Non-small Cell Lung Cancer, Melanoma

Pierre Fabre Medicament

Phase 1

400

Haerbin, Linyi, Beijing, Shanghai

2021-08-04

Recruiting

Surufatinib Plus Camrelizumab and AS in First Line Treatment of Advanced Metastatic Pancreatic Cancer

NCT05218889Pancreatic Cancer, PDAC - Pancreatic Ductal Adenocarcinoma, Pancreas Cancer, Pancreatic Neoplasms

DrugsSurufatinib·Teysuno·Camrelizumab·Nab-paclitaxel

Chinese PLA General Hospital

Phase 1/2

Beijing

2021-08-04

Recruiting

Para-aortic Prophylactic Irradiation for Locally Advanced Cervical Cancer

NCT04974346Cervical Cancer

Zhejiang Cancer Hospital

Phase 3

455

Hangzhou, Jinhua, Lishui, Ningbo, Taizhou, Wanzhou

2021-08-02

Recruiting

Orelabrutinib Plus Rituximab Followed by Maintenance With Orelabrutinib for Relapsed and Refractory Follicular Lymphoma(RR FL)

NCT04989621Follicular Lymphoma, Relapsed and Refractory Follicular Lymphoma

DrugOrelabrutinib

Sun Yat-sen University

Phase 2

Guangzhou

2021-08-01

By invitation

Efficacy and Safety of Almonertinib Combined With or Without Chemotherapy as an Adjuvant Treatment for Stage II-IIIA Non-small Cell Lung Carcinoma Following Complete Tumour Resection

NCT04762459Non-small Cell Lung Carcinoma

DrugsAlmonertinib·Pemetrexed·Cisplatin

Chinese Academy of Medical Sciences

Phase 3

606

Beijing, Changsha, Chendu, Chengdu, Chongqing, Fuzhou, Guangzhou, Hangzhou

2021-08-01

By invitation

Chinese Multicenter Clinical Outcome Cohort Study of Myotonic Dystrophy Type 1 (C-DMCOS-DM1)

NCT06101940Myotonic Dystrophy 1

Huashan Hospital

Observational

1,000

Beijing, Chongqing, Fuzhou, Guangzhou, Shijiazhuang, Wuhan, Nanjing, Suzhou

2021-08-01

Not yet open

Neurological Sequelae in Patients With Acute Carbon Monoxide Poisoning

NCT04925297Carbon Monoxide Poisoning

The First Hospital of Jilin University

Observational

1,250

Changchun

2021-08-01

By invitation

FHND9041 Versus Afatinib for Non-small Cell Lung Cancer

NCT06759857Non Small Cell Lung Cancer

DrugAfatinib

Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd.

Phase 3

350

Beijing

2021-08-01

Recruiting

Closed-loop Functional Spinal Cord Stimulation in Patients With Spinal Cord Injury

NCT04969042Spinal Cord Injuries

Luming Li

Phase 1

Beijing

2021-08-01

Recruiting

Clinical Study of Desuzumab in the Treatment of Knee Osteoarthritis

NCT06357741Knee Osteoarthritis

DrugDenosumab

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Observational

Wuhan

2021-08-01

Recruiting

Neoadjuvant Dose-dense Chemotherapy for HR+/HER2- Breast Cancer Patients With High Proliferation Index

NCT05728268Breast Cancer

Shantou Central Hospital

Phase 2

Shantou

2021-08-01

Recruiting

The Efficacy and Safety of the Bispecific Anti-PD-1/PD-L1 Antibody IBI318 Combined with Lenvatinib in NSCLC.

NCT04777084Non-Small Cell Lung Cancer

Hunan Province Tumor Hospital

Phase 2

120

Changsha

2021-08-01

Recruiting

Efficacy and Safety of Pyrotinib Maleate Combined With ARX788 Neoadjuvant Treatment in Breast Cancer Patients

NCT04983121Breast Neoplasms

Shengjing Hospital

Phase 2

Shenyang

2021-08-01

Active, closed

PD-1 Blockade Combined With De-intensified Chemoradiotherapy Sparing Concurrent Cisplatin in Nasopharyngeal Carcinoma

NCT04907370Nasopharyngeal Carcinoma

DrugsGemcitabine·Cisplatin

Sun Yat-sen University

Phase 3

532

Beijing, Chongqing, Foshan, Guangzhou, Nanning, Guiyang, Wuhan, Changsha

2021-08-01

Recruiting

The Brain Mechanism of Social Emotion and Communication in Infants Aged 0 to 6 Years

NCT05040542Brain Development, Behavior Disorders, Child, Intellectual Developmental Disorders

Children's Hospital of Fudan University

Observational

3,001

Xiamen

2021-08-01

Not yet open

Trastuzumab Combined With Pertuzumab for Adjuvant Treatment of Breast Cancer After Neoadjuvant Therapy

NCT04973319Breast Cancer

DrugsPyrotinib·Pertuzumab·Trastuzumab

Shengjing Hospital

Phase 3

450

Shenyang

2021-08-01

Not yet open

Penpulimab-based Combination Neoadjuvant/Adjuvant Therapy for Patients With Resectable Locally Advanced Non-small Cell Lung Cancer: a Phase II Clinical Study (ALTER-L043)

NCT04846634Resectable Locally Advanced Non-small Cell Lung Cancer

DrugsPenpulimab·Cisplatin/Carboplatin·Anlotinib

Tianjin Medical University Cancer Institute and Hospital

Phase 2

Nanchang

2021-08

Active, closed

China Subpopulation: Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma

NCT06868654Multiple Myeloma

DrugsBelantamab mafodotin·Bortezomib·Daratumumab·Dexamethasone

GlaxoSmithKline

Phase 3

Beijing, Changchun, Guangzhou, Hangzhou, Jinan, Nanjing, Shenyang, Suzhou

2021-07-28

Active, closed

A Phase Ⅲ Clinical Study of Combined Cisplatin Versus Placebo Combined With Intracavitary Cisplatin Injection in the Treatment of Malignant Pleural Effusions

NCT04914598Malignant Pleural Effusion

Jiangsu Simcere Pharmaceutical Co., Ltd.

Phase 3

290

Nanjing

2021-07-28

Recruiting

Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.

NCT04817618C3G

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

Guangzhou, Wuhan, Beijing, Shanghai

2021-07-28

Active, closed

Long-term Safety and Tolerability of Iptacopan in Patients With Paroxysmal Nocturnal Hemoglobinuria

NCT04747613Paroxysmal Nocturnal Hemoglobinuria

DrugIptacopan

Novartis Pharmaceuticals

Phase 3

208

Beijing, Tianjin

2021-07-27

Recruiting

Evaluate the Efficacy and Safety of FB825 in Adult With Allergic Asthma

NCT05008965Allergic Asthma

DrugFB825

Oneness Biotech Co., Ltd.

Phase 2

100

2021-07-27

By invitation

A Study to Evaluate the Safety and Tolerability of Dapirolizumab Pegol in Study Participants With Systemic Lupus Erythematosus

NCT04976322Systemic Lupus Erythematosus

UCB Biopharma SRL

Phase 3

760

Beijing, Changchun, Guangzhou, Guilin, Shanghai, Shantou, Suzhou, Tianjin

2021-07-27

Active, closed

A Study of JAB-21822 in Adult Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation in China

NCT05009329NSCLC, Solid Tumor

DrugGlecirasib

Allist Pharmaceuticals, Inc.

Phase 1/2

315

Beijing

2021-07-26

By invitation

The GUARDIAN Trial - Vasopressor Sub-Study

NCT04934748Blood Pressure

DrugsPhenylephrine·Norepinephrine

The University of Texas Health Science Center, Houston

Phase 4

6,254

Beijing, Shanghai, Sichuan

2021-07-25

Active, closed

the Aorta Arch Stent Graft System Combined With the Endovascular Needle System in Situ Fenestration

NCT05126446Aortic Dissection

Lifetech Scientific (Shenzhen) Co., Ltd.

Not applicable

120

Changsha

2021-07-25

Recruiting

The GUARDIAN Trial

NCT04884802Blood Pressure

The University of Texas Health Science Center, Houston

Not applicable

6,254

Beijing, Chengdu, Hong Kong, Shanghai, Xuzhou

2021-07-25

By invitation

The GUARDIAN Trial - Induction Agent Sub-Study

NCT04934683Major Surgery

The University of Texas Health Science Center, Houston

Phase 4

6,254

Shanghai, Beijing, Sichuan

2021-07-25

Active, closed

Camrelizumab Combined With Famitinib Malate for Treatment of Recurrent/Metastatic Cervical Cancer

NCT04906993Cervical Cancer

Jiangsu HengRui Medicine Co., Ltd.

Phase 3

443

Shanghai

2021-07-23

Active, closed

Newly Diagnosed Glioblastoma

NCT04959500Glioblastoma

DrugsAnlotinib hydrochloride·Temozolomide

Sun Yat-sen University

Phase 2

150

Bengbu, Beijing, Chongqing, Fuzhou, Lanzhou, Guangzhou, Shenzhen, Zhuhai

2021-07-21

Recruiting

Study of Adjuvant Chemotherapy With or Without PD-1 Inhibitors and Chemoradiotherapy in Resected pN3 Gastric (G) or GEJ Adenocarcinoma

NCT04997837Gastric Cancer

DrugsTegafur-gimeracil-oteracil potassium·Adrucil·Capecitabine·Oxaliplatin

Fudan University

Phase 3

433

Shanghai

2021-07-21

Recruiting

Comparison of Segmentectomy Versus Lobectomy for Non-small Cell Lung Cancer ≤ 2 cm in the Middle Third of the Lung Field

NCT04944563Lung Neoplasms, Surgery

The First Affiliated Hospital with Nanjing Medical University

Not applicable

1,120

Nanjing

2021-07-20

Active, closed

Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy and Camrelizumab in Locally Advanced Rectal Cancer (UNION)

NCT04928807Rectal Cancer

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Phase 3

231

Wuhan

2021-07-20

Recruiting

Albumin-bound Paclitaxel and Carboplatin Versus Epirubicin and Docetaxel for Triple-negative Breast Cancer

NCT04136782Breast Cancer

DrugsAlbumin-Bound Paclitaxel·Epirubicin·Docetaxel·Carboplatin

Shengjing Hospital

Phase 4

110

Harbin, Changchun, Dalian, Panjin, Shenyang

2021-07-19

Recruiting

Treatment of Triple-negative Breast Cancer With Albumin-bound Paclitaxel as Neoadjuvant Therapy: a Prospective RCT

NCT04137653Breast Cancer

DrugsNab-paclitaxel·Paclitaxel·Carboplatin

Shengjing Hospital

Phase 3

1,498

Shenyang

2021-07-19

Recruiting

Sj-subway, a Predictor for the Recurrence of High-risk Hormone Receptor-positive Breast That is Sensitive to Extended Endocrine Therapy

NCT04476485Breast Cancer

Shengjing Hospital

Observational

1,000

Harbin, Changchun, Dalian, Panjin, Shenyang

2021-07-19

Active, closed

Sunvozertinib (DZD9008) in Pretreated Lung Cancer Patients with EGFR Exon20 Insertion Mutation (WU-KONG6)

NCT05712902Non-Small Cell Lung Cancer

DrugSunvozertinib

Dizal Pharmaceuticals

Phase 2

104

Beijing, Changchun, Changsha, Chengdu, Chongqing, Guangzhou, Haikou, Hangzhou

2021-07-19

Active, closed

Evolut PRO China Clinical Study

NCT04982588Severe, Symptomatic Aortic Stenosis

Medtronic Cardiovascular

Not applicable

Beijing, Chengdu, Hangzhou

2021-07-17

Active, closed

A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus

NCT04961567Lupus Erythematosus, Systemic

DrugLitifilimab

Biogen

Phase 3

562

Beijing, Dongguan, Guangzhou, Shenzhen, Haikou, Changsha, Zhuzhou, Wuhan

2021-07-16

Active, closed

A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment

NCT04908189Psoriatic Arthritis

DrugsApremilast·Deucravacitinib

Bristol-Myers Squibb

Phase 3

729

Bengbu, Beijing, Guangzhou, Shenzhen, Zhengzhou, Changsha, Changzhou, Nanjing

2021-07-15

Recruiting

A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

NCT04951622Myasthenia Gravis

DrugNipocalimab

Janssen Research & Development, LLC

Phase 3

199

Beijing, Changchun, Changsha, Chengdu, Fuzhou, Guangzhou, Hangzhou, Jinan

2021-07-15

Recruiting

Efficacy of Prophylactic Epinephrine Solution Injection in Prevention of Delayed Post-sphincterotomy

NCT04964869Bleeding Hemorrhage

Wen-Hsin Huang

Not applicable

400

2021-07-15

Recruiting

TACE Combined With Tislelizumab in Patients With Advanced Intrahepatic Cholangiocarcinoma

NCT04954781Intrahepatic Cholangiocarcinoma

DrugTislelizumab

Fudan University

Phase 2

Shanghai

2021-07-14

Active, closed

A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease-modifying Anti-rheumatic Drugs

NCT04908202Psoriatic Arthritis

DrugDeucravacitinib

Bristol-Myers Squibb

Phase 3

670

Hefei, Beijing, Chongqing, Guangzhou, Shenzhen, Dalian, Shanghai, Yiwu

2021-07-13

Active, closed

Phase II Neoadjuvant Pyrotinib Combined With Neoadjuvant Chemotherapy in HER2-low-expressing and HR Positive Early or Locally Advanced Breast Cancer: a Single-arm, Non-randomized, Single-center, Open Label Trial

NCT05165225Breast Cancer, HER2-low-expressing Breast Cancer, Hormone Receptor-positive Breast Cancer, Neoadjuvant Therapy

DrugPyrotinib

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Phase 2

Guangzhou

2021-07-13

Active, closed

A Study of JNJ-78278343, a T-Cell-Redirecting Agent Targeting Human Kallikrein 2 (KLK2), for Advanced Prostate Cancer

NCT04898634Prostatic Neoplasms

DrugPasritamig

Janssen Research & Development, LLC

Phase 1

216

Beijing, Chongqing, Guangzhou, Wenzhou

2021-07-13

Recruiting

International Headache Registry Study

NCT05418218Headache Disorders, Primary, Headache Disorders, Secondary, Migraine, Tension-Type Headache

Second Affiliated Hospital, Zhejiang University, School of Medicine

Observational

200,000

Hangzhou

2021-07-12

Active, closed

PERformance of Multi-Cancer Early-detectIon Based on Various Biomarkers in fEmale BREAST Cancers, PERCEIVE-BREAST

NCT06979921Cancer

The First Affiliated Hospital with Nanjing Medical University

Observational

496

Nanjing, Qingdao

2021-07-10

Recruiting

Neoadjuvant Toripalimab or Toripalimab in Combination With Carboplatin and Nab-paclitaxel in Untreated HNSCC (HNSCC-002)

NCT04807140Head and Neck Squamous Cell Carcinoma

DrugToripalimab

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Phase 2

Guangzhou

2021-07-08

Recruiting

Enteral Nutrition in Infants With Ileostomy

NCT04707443Nutrition of Ileostomy Infants

Children's Hospital of Fudan University

Observational

110

Shanghai

2021-07-08

By invitation

A Multicenter Phenotype-Genotype Analysis of LGMD Patients in China

NCT04989751LGMD, LGMDR2, LGMDR1

Huashan Hospital

Observational

450

Shanghai

2021-07-07

Recruiting

Knee-Hip-Spine Harmony: The Relationship Between Sagittal Spinal Alignment in Total Hip/Knee Arthroplasty

NCT05685706Cases Who Received TKA/THA

China Medical University Hospital

Observational

300

2021-07-07

Recruiting

A Study of LP-168 in Participants With Relapse or Refractory B-Cell Lymphoma

NCT04993690B-cell Lymphoma

DrugRocbrutinib

Guangzhou Lupeng Pharmaceutical Company LTD.

Phase 1

200

Beijing, Guangzhou

2021-07-06

Recruiting

Long-term of Remote Ischemic Preconditioning and Mindfulness in Patients With Mild Hypertension

NCT04753840Hypertension

Henan Institute of Cardiovascular Epidemiology

Not applicable

400

Zhengzhou

2021-07-03

Recruiting

Drug Eluting Stenting and Aggressive Medical Treatment for Preventing Recurrent Stroke in Intracranial Atherosclerotic Disease Trial

NCT04948749ICAD - Intracranial Atherosclerotic Disease, ICAS - Intracranial Atherosclerosis, Drug-eluting Stent, Stroke

Beijing Tiantan Hospital

Not applicable

358

Beijing, Cangzhou, Tangshan, Xingtai, Wuhan, Baotou, Hohhot, Tongliao

2021-07-02

Recruiting

Diagnosis and Treatment of Foreign Bodies Outside Pharynx and Esophagus Lumen

NCT04917367Surgery

Second Affiliated Hospital, Zhejiang University, School of Medicine

Observational

Hangzhou

2021-07-02

Recruiting

Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)

NCT04886804Neoplasm Metastasis, Non-Small Cell Lung Cancer

DrugZongertinib

Boehringer Ingelheim

Phase 1

554

Beijing, Changchun, Fuzhou, Guangzhou, Hangzhou, Harbin, Nanning, Shanghai

2021-07-02

Active, closed

Phase I Clinical Protocol for Pre-evaluation of the Safety of BCG-PPD in Tuberculosis Patients

NCT04538911Tuberculosis

Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.

Phase 1

Shenzhen

2021-07-02

Recruiting

Compare Continuation of Original Targeted Therapy With Trastuzumab Combined With Pyrotinib and Capecitabine as Postoperative Adjuvant Therapy in Non-pCR Patients With HER2 Positive Early Breast Cancer

NCT05292742Breast Cancer, Adjuvant Therapy

DrugsPertuzumab/Trastuzumab·Pyrotinib·Trastuzumab·Capecitabine

Fujian Medical University Union Hospital

Phase 2

206

Fuzhou

2021-07-02

Not yet open

An Open-label, Multicentre, Phase II/III RCT of PFLL Versus GP Combined With JS001 as the First-line Therapy for mNPC

NCT04890522Nasopharyngeal Carcinoma, Metastasis, Chemotherapy, Immunotherapy

DrugsJS001·Adrucil·Gemcitabine·Cisplatin

Sun Yat-sen University

Phase 2/3

622

Guangzhou

2021-07-01

Recruiting

Oral Dydrogesterone as Luteal Phase Support in Natural Cycle FET

NCT03859921Subfertility

DrugDydrogesterone

The University of Hong Kong

Phase 3

716

Hong Kong

2021-07-01

Active, closed

A Study of SHR-A1904 in Patients With Advanced Solid Cancer

NCT04877717Advanced Solid Cancer

DrugSHR-A1904

Shanghai Hengrui Pharmaceutical Co., Ltd.

Phase 1

107

Guangzhou

2021-07-01

Active, closed

Selected Chemotherapy Combined Immunotherapy Treated High Risk Patient After NCRT in Resected Locally Advanced ESCC

NCT05189730Esophageal Squamous Cell Carcinoma

DrugsTirelizumab·Paclitaxel·Carboplatin

Sichuan Cancer Hospital and Research Institute

Phase 2

Chengdu

2021-07-01

Recruiting

EyeConic: Qualification for Cone-Optogenetics

NCT05294978Retinal Dystrophies

Institute of Molecular and Clinical Ophthalmology Basel

Observational

1,000

Beijing

2021-07-01

Recruiting

Prognostic Effect of Whether Doing PLND During RC for High-risk NMIBC

NCT05123625Bladder Cancer

The First Affiliated Hospital with Nanjing Medical University

Not applicable

200

Nanjing

2021-07-01

Recruiting

The Effectiveness and Safety of SBRT in the Treatment of Patients With MPLC After Surgery (SMILE)

NCT05113017The Efficacy and Safety of SBRT in MPLC

Fang Wu

Observational

Changsha, Wuhan

2021-07-01

Recruiting

Baduanjin Training for Depression and Anxiety Patients

NCT05589337Depression Symptoms, Anxiety Symptoms

Shanghai University of Traditional Chinese Medicine

Not applicable

120

Shanghai

2021-07-01

Recruiting

A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFH

NCT05283993Multiple Myeloma, Amyloidosis, Cryoglobulinemia, Castleman's Disease

Peking University First Hospital

Observational

2,000

Beijing

2021-07-01

Recruiting

ENMS With Balance Feedback for Post-stroke Ankle-foot Rehabilitation

NCT04934787Cerebrovascular Stroke, Foot Drop, Foot Inversion Deformity

The Hong Kong Polytechnic University

Not applicable

Hong Kong

2021-07-01

Recruiting

The Immune Assessment of PD-1 Antibody Therapy in Tumor

NCT06693440Efficacy, Team, Adverse Event

DrugsVenetocalx·Nivolumab·Pembrolizumab

Quanli Gao

Observational

3,000

Zhengzhou

2021-07-01

Recruiting

Orelabrutinib, Sintilimab and Temozolomide in Relapsed or Refractory Central Nervous System Lymphoma

NCT04961515Primary Central Nervous System Hodgkin Lymphoma

DrugsOrelabrutinib·Temozolomide·Sintilimab

Second Affiliated Hospital, Zhejiang University, School of Medicine

Phase 2

Hangzhou

2021-07-01

Not yet open

Adjuvant Radiotherapy in Patients With Early Endometrial Cancer

NCT04956601Endometrial Cancer, Pathology, Radiotherapy

Peking University Third Hospital

Not applicable

480

Beijing

2021-07

Not yet open

Study of Nimotuzumab Combined With IMRT in Elder Patients With Cervical Squamous Cell Carcinoma

NCT04976478Cervical Squamous Cell Carcinoma

DrugNimotuzumab

Peking University Third Hospital

Observational

125

Beijing

2021-07

Not yet open

Diabetes Complications and the Risk of Cardiovascular and Cerebrovascular Diseases

NCT04983277Diabetes Complications, Cardiovascular Diseases, Cerebrovascular Disease

Second Affiliated Hospital, Zhejiang University, School of Medicine

Observational

3,000

Hangzhou

2021-07

Recruiting

A Study of GC101 TIL in r/r Gastrointestinal Tumors (10hospital)

NCT04960072Gastrointestinal Tumor

DrugTumor Infiltrating Lymphocytes

Shanghai Juncell Therapeutics

Early Phase 1

Shanghai

2021-06-30

Active, closed

Phase ll Study of HEC585 in Patients With IPF

NCT05060822Idiopathic Pulmonary Fibrosis

DrugsHEC585·Pirfenidone

Sunshine Lake Pharma Co., Ltd.

Phase 2

270

Beijing

2021-06-30

Recruiting

Comparison of Chemoradiotherapy and Chemoradiotherapy Combined With Consolidation Chemotherapy for ESCC

NCT05775419Esophageal Squamous Cell Carcinoma, Chemotherapy Effect, Side Effect of Drug

The First Affiliated Hospital with Nanjing Medical University

Not applicable

1,216

Nanjing

2021-06-30

Recruiting

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

NCT04900818Solid Tumor, Advanced Cancer, Metastatic Cancer, Gastric Cancer

DrugGivastomig

I-Mab Biopharma US Limited

Phase 1

330

Hefei, Beijing, Guangzhou, Harbin, Zhengzhou, Wuhan, Shenyang, Shanghai

2021-06-29

Active, closed

Study to Assess the Safety, Tolerability, and Efficacy of IDX-1197 in Combination With XELOX or Irinotecan in Patients With Advanced Gastric Cancer

NCT04725994Gastric Cancer

DrugsXelox·Irinotecan

Idience Co., Ltd.

Phase 1/2

Beijing, Guangzhou, Shanghai

2021-06-28

Active, closed

A Study of TQ05105 in Patients With Chronic Graft Versus Host Disease

NCT04944043Chronic Graft Versus Host Disease

DrugRovadicitinib

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Phase 1/2

Hefei, Guangzhou, Nanning, Shijiazhuang, Zhengzhou, Wuhan, Suzhou, Tianjin

2021-06-25

Recruiting

Toripalimab Plus FLOT in Locally Advanced Gastric Cancer

NCT04891016Chemotherapy, Immune Checkpoint Inhibitor, Locally Advanced Gastric Carcinoma

DrugsFLOT·Toripalimab

Henan Cancer Hospital

Phase 2

Zhengzhou

2021-06-25

Active, closed

A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy

NCT04629248Primary Membranous Nephropathy

DrugsDiphenhydramine·Acetaminophen·Tacrolimus·Methylprednisolone

Hoffmann-La Roche

Phase 3

142

Hangzhou, Beijing, Chengdu, Fuzhou, Guangzhou, Shanghai, Wuhan, Xi'an

2021-06-25

Active, closed

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

NCT04793958Advanced Colorectal Cancer, Metastatic Colorectal Cancer

DrugsAdagrasib·MFOLFOX6·Erbitux·Folfox

Mirati Therapeutics Inc.

Phase 3

461

Bengbu, Hefei, Beijing, Fuzhou, Guangzhou, Shenzhen, Nanning, Zhengzhou

2021-06-24

Active, closed

Study on Olaparib Plus Abiraterone as First-line Therapy in Men With Metastatic Castration-resistant Prostate Cancer (China Cohort)

NCT05171816Metastatic Castration-resistant Prostate Cancer

DrugsZytiga·Abiraterone acetate·Olaparib

AstraZeneca

Phase 3

110

Beijing, Chongqing, Guangzhou, Guizhou, Henan, Hubei, Hunan, Jilin City

2021-06-24

By invitation

Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China

NCT04961450Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Motor Neuron Disease

Peking University Third Hospital

Observational

2,500

Beijing

2021-06-24

Recruiting

A Prospective Multicenter Clinical Study of SCCG Protocol and ctDNA 5hmc in Predicting the Chemotherapy Sensitivity and Monitoring the Recurrence and Metastasis of Hepatoblastoma in Children and Adolescents

NCT07300449Hepatoblastoma

Sun Yat-sen University

Phase 2

100

Guangzhou

2021-06-23

Recruiting

The Research Plan of Taiwan Precision Medicine

NCT04849481Non-small-cell Lung Cancer

National Health Research Institutes, Taiwan

Observational

550

2021-06-23

Active, closed

Protection of Cardiac Function With Left Bundle Branch Pacing in Patients With Atrioventricular Block

NCT04624763Atrioventricular Block

The First Affiliated Hospital with Nanjing Medical University

Not applicable

683

Nanjing

2021-06-22

Active, closed

Tenofovir Alafenamide Switching Therapy in Kidney or Liver Transplant Recipients With Chronic HBV Infection

NCT05410496Safety Issues, Chronic Hepatitis B, Transplant Recipient

DrugTenofovir Alafenamide

Taichung Veterans General Hospital

Phase 4

2021-06-22

Recruiting

Omics Sequencing of Specimen Derived From Mother-Infant-Pairs

NCT05462366Healthy, Breast-milk Collection, Feces

Zhujiang Hospital

Observational

100

Guangzhou

2021-06-22

Recruiting

A Study of Toripalimab as Consolidation Therapy After Postoperative Chemoradiotherapy in HNSCC

NCT04992559Head and Neck Squamous Cell Carcinomas

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Phase 2

Guangzhou

2021-06-22

Recruiting

Gene Therapy Clinical Trial for the Treatment Of Leber's HereDitary Optic Neuropathy

NCT04912843Leber's Hereditary Optic Neuropathy (LHON)

Wuhan Neurophth Biotechnology Limited Company

Phase 2/3

102

Beijing

2021-06-18

Active, closed

Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

NCT04895358Breast Neoplasms

DrugsLiposomal doxorubicin·Abraxane·Xeloda·Taxol

Merck Sharp & Dohme LLC

Phase 3

342

Hefei, Beijing, Xiamen, Foshan, Guangzhou, Shenzhen, Nanning, Zhengzhou

2021-06-18

Active, closed

A Trial of AK117 (Anti-CD47) in Patients With Myelodysplastic Syndrome

NCT04900350Myelodysplastic Syndrome

DrugsLigufalimab·Azacitidine

Akeso

Phase 1/2

136

Suzhou

2021-06-18

Recruiting

Effect of Huaier Granule on Adjuvant Treatment for High-risk Early-stage Triple-negative Breast Cancer

NCT04790305Carcinoma Breast, Triple-negative Breast Cancer, Invasive Ductal Carcinoma, Breast

DrugHuaier

Fudan University

Phase 4

1,072

Hefei, Beijing, Chongqing, Fuzhou, Guangzhou, Shijiazhuang, Harbin, Zhengzhou

2021-06-18

Recruiting

Perioperative EEG-Monitoring and Postoperative Delirium in Patients Undergoing Cardiovascular Surgery

NCT04832568Delirium

Huazhong University of Science and Technology

Observational

200

Wuhan

2021-06-17

Active, closed

A Study of Guselkumab in Participants With Active Psoriatic Arthritis

NCT04882098Arthritis, Psoriatic

DrugGuselkumab

Janssen Research & Development, LLC

Phase 3

1,054

Baoding, Baotou, Beijing, Bengbu, Changchun, Changzhou, Chengdu, Chongqing

2021-06-17

Active, closed

The Effect of Metformin in Patients With Newly Diagnosed mHSPC

NCT04925063Metastatic Prostate Cancer

DrugMetformin

Sun Yat-sen University

Phase 2

266

Guangzhou

2021-06-16

Active, closed

Neoadjuvant Safety of Sintilimab + XELOX + Bevacizumab in PMMR/MSS CRLM Patients

NCT04940546Colorectal Cancer Metastatic

DrugsXeloda·Avastin·Sintilimab·Capecitabine

Sun Yat-sen University

Phase 1/2

Guangzhou

2021-06-16

Recruiting

Efficacy and Safety of Gushen Antai Pill on Ongoing Pregnancy Rate in Women With Normal Ovarian Reserve Undergoing IVF-ET

NCT04872660Infertility, Female

Shandong University of Traditional Chinese Medicine

Phase 4

800

Jinan

2021-06-15

Recruiting

Diagnostic Efficacy of CNN in Predicting Intraoperative Complications and Postoperative Outcomes in SMILE

NCT06204926Deep Convolutional Neural Network, Small-incision Lenticule Extraction (SMILE) Surgery, Intraoperative Complications, Postoperative Outcomes

Second Affiliated Hospital of Nanchang University

Observational

1,250

Nanchang

2021-06-15

Recruiting

Population Pharmacokinetics of Terbinafine in Children With Tinea Capitis

NCT07046988Tinea Capitis

DrugTerbinafine

Shandong University

Observational

Beijing

2021-06-15

Recruiting

Omega-3 Fatty Acids, Inflammation, Gut Microbiota in Youth With Depression

NCT07363551ADHD

China Medical University Hospital

Not applicable

2021-06-09

Active, closed

Safety and Efficacy of Camrelizumab for High-risk NMIBC Failing BCG Treatment

NCT04706598Urinary Bladder Neoplasms, Immunotherapy

DrugCamrelizumab

Fudan University

Phase 1/2

Shanghai

2021-06-09

Active, closed

An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With Standard of Care (SoC), Versus SoC Alone, in Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC)

NCT04720157Prostatic Neoplasms

DrugsARDT·Illuccix·Lu-PSMA

Novartis Pharmaceuticals

Phase 3

1,144

Nanjing, Xian, Chengdu, Beijing, Guangzhou, Shanghai, Tianjin

2021-06-09

Active, closed

Guo's Aortic Arch Reconstruction :The Prospective ,Multiple Center Study About the Safety and Efficacy of WeFlow-Arch Modeler Embedded Branch Stent Graft System (GIANT Study)

NCT04765592Aortic Arch Aneurysm

Hangzhou Endonom Medtech Co., Ltd.

Not applicable

Beijing, Changsha, Chengdu, Guangzhou, Hangzhou, Harbin, Jinan, Kunming

2021-06-07

Recruiting

To Assess the Efficacy and Safety of Furmonertinib Versus Placebo, in Patients With Epidermal Growth Factor Receptor Mutation Positive Stage II-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy

NCT04853342Non-small Cell Lung Carcinoma

DrugFurmonertinib

Allist Pharmaceuticals, Inc.

Phase 3

318

Suzhou

2021-06-07

Active, closed

Evaluation of Impedance Cardiography for Assessing Hemodynamic Shifts in Patients With LA-NSCLC During Treatment.

NCT06277388Non-small Cell Lung Cancer, Cardiac Toxicity

Sun Yat-sen University

Observational

231

Guangzhou

2021-06-05

Recruiting

Neoadjuvant Toripalimab in Combination With Gemcitabine and Cisplatin Therapy in Local Advanced Bladder Cancer Subjects

NCT04861584Urinary Bladder Cancer

DrugsNeoadjuvant toripalimab·Gemcitabine and cisplatin

Zhujiang Hospital

Phase 2

Guangzhou

2021-06-03

Active, closed

A Clinical Study to Evaluate the Long-Term Safety Sodium Oligomannate Capsules (GV-971)

NCT05058040Alzheimer Disease

DrugSodium Oligomannate

Green Valley (Shanghai) Pharmaceuticals Co., Ltd.

Phase 4

2,500

Hefei, Beijing, Chongqing, Xianmencun, Dongguan, Guangzhou, Shenzhen, Zhuhai

2021-06-02

Not yet open

Factors Influencing the Prognosis of Olfactory Dysfunction After Upper Sensation

NCT04918953Outcome

DrugMethylprednisolone

Second Affiliated Hospital, Zhejiang University, School of Medicine

Phase 2

Hangzhou

2021-06-02

Recruiting

Pyrotinib Combined With Trastuzumab for Maintenance Therapy After First-line TH (P) Therapy for HER2+ABC

NCT06754059HER2-positive Breast Cancer

DrugPyrotinib

zhangjie

Observational

Fuzhou

2021-06-01

Recruiting

Coronary Artery Calcification in Type 2 Diabetes Mellitus (USCAC Study)

NCT04889053Type 2 Diabetes, Vascular Calcification, Coronary Artery Calcification, Strains

University of South China

Observational

1,400

Hengyang

2021-06-01

Active, closed

Establish a Specific Cohort Database for Depressive Disorders

NCT05095662Depressive Disorder

Shanghai Mental Health Center

Observational

80,000

Shanghai

2021-06-01

Recruiting

Clinical Study for AL-CM

NCT04924998Immunoglobulin Light Amyloidosis Cardiomyopathy

Second Affiliated Hospital, Zhejiang University, School of Medicine

Observational

400

Hangzhou

2021-06-01

Recruiting

68Ga-PSMA PET in the Renal Cell Carcinoma

NCT04987086Renal Cancer, Metastases, PSMA PET

Xijing Hospital

Not applicable

300

Lanzhou, Yinchuan, Xining, Xi'an, Weinan, Xianyang, Yan’an

2021-06-01

Recruiting

Early Specialized Cardiovascular Intervention Based on Impedance Cardiography in Locally Advanced Non-small Cell Lung Cancer Patients

NCT04980716Non-small Cell Lung Cancer, Cardiovascular Complication

Sun Yat-sen University

Phase 3

524

Guangzhou

2021-06-01

Recruiting

Total Parathyroidectomy With Autotransplantation Versus Total Parathyroidectomy Alone for Secondary Hyperparathyroidism

NCT04922892Secondary Hyperparathyroidism;Parathyroidectomy

The Second Hospital of Nanjing Medical University

Not applicable

200

Nanjing

2021-06-01

Recruiting

Development of Novel Gastric Cancer Screening and Diagnosis Technologies Using Tongue Imaging and Study of Tongue Image Changes Mechanisms

NCT06078930Gastric Cancer, Tongue Images, Diagnosis

Zhejiang Cancer Hospital

Observational

100,000

Hangzhou

2021-06-01

Recruiting

National Longitudinal Cohort of Hematological Diseases (NICHE) - CART

NCT06607289Hematological Malignancies

Institute of Hematology & Blood Diseases Hospital, China

Observational

1,000

Tianjin

2021-06-01

Recruiting

Clinical Study of ATTR-CM

NCT04935021Transthyroxine Amyloidosis Cardiomyopathy

Second Affiliated Hospital, Zhejiang University, School of Medicine

Phase 4

100

Hangzhou

2021-06-01

Recruiting

Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer

NCT06482086Locally Advanced Thyroid Gland Carcinoma

DrugsVandetanib·Pralsetinib·Donafenib·Larotrectinib

West China Hospital

Phase 2

Chengdu

2021-06-01

Recruiting

Comparison of MBR + Suture Tape and MBR for CLAI : A Prospective Cohort Study

NCT06897293Ankle Sprain, Hypermobility, Joint

Peking University Third Hospital

Observational

Beijing

2021-06-01

Recruiting

Intracranial Pressure Monitoring in Moderate Traumatic Brain Injury

NCT04900168Moderate Traumatic Brain Injury

Tang-Du Hospital

Observational

1,000

Xi'an

2021-06-01

Recruiting

Hepatectomy Combined With Camrelizumab and Apatinib in CNLC Stage IIIb HCC

NCT05062837Hepatocellular Carcinoma

DrugCamrelizumab and apatinib

Guangxi Medical University

Phase 2/3

Nanning

2021-06-01

Active, closed

Sintilimab Combined With Chemotherapy Induction Therapy Followed by CCRT vs. CCRT for Esophageal Cancer: A Randomized Controlled Phase Ⅲ Clinical Study

NCT07306663Esophageal Cancer

DrugSintilimab

Jiangsu Cancer Institute & Hospital

Phase 3

242

Nanjing

2021-06-01

Recruiting

Clinical Study of Endocardial Myocardial Biopsy

NCT05718128Myocarditis, Cardiomyopathies, Heart Failure, Cardiac Tumor

Second Affiliated Hospital, Zhejiang University, School of Medicine

Phase 4

100

Hangzhou

2021-06-01

Recruiting

Niraparib Monotherapy as Maintain and Recurrent Treatment of Endometrial Serous Carcinoma

NCT04716686Endometrial Carcinoma, Serous Carcinoma

DrugNiraparib

Shandong University

Phase 2

Jinan

2021-06-01

Recruiting

Camrelizumab Plus Stereotactic Body Radiotherapy vs Camrelizumab Alone For Oligometastatic Nasopharyngeal Carcinoma

NCT04944914Nasopharyngeal Carcinoma

DrugCamrelizumab

Sun Yat-sen University

Phase 3

188

Guangzhou

2021-06-01

Recruiting

Safety and Efficacy of TAF to Prevent MTCT of HBV in Middle/Late Pregnancies With High HBV DNA Load

NCT05466071Chronic Hepatitis b, Pregnancy Related

Xingfei Pan

Observational

200

Guangzhou

2021-06-01

Active, closed

D9319C00001- 1L OC Mono Global RCT

NCT04884360Ovarian Cancer

DrugOlaparib

AstraZeneca

Phase 3

366

Baoji, Beijing, Changchun, Changsha, Chengdu, Chongqing, Guangzhou, Guiyang

2021-05-31

Active, closed

Phacotrabeculectomy Versus Phacogoniotomy (PVP) in Advanced Primary Angle-closure Glaucoma

NCT04878458Glaucoma, Angle-Closure

Sun Yat-sen University

Not applicable

124

Guangzhou, Guangdong

2021-05-31

Recruiting

Pneumoconiosis and Dust Exposure China Cohort

NCT07077382Pneumoconiosis

China-Japan Friendship Hospital

Observational

2,000

Beijing

2021-05-28

Active, closed

A Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy as First-line Treatment in Subjects With RAS/BRAF Wild Metastatic Colorectal Cancer

NCT04854668Metastatic Colorectal Cancer

DrugsAnlotinib hydrochloride·Capecitabine·Oxaliplatin·Bevacizumab

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Phase 3

748

Chizhou, Fuzhou, Hefei, Xuancheng, Beijing, Chongqing, Xiamen, Lanzhou

2021-05-27

Recruiting

APG-115 in Combination With PD-1 Inhibitor in Patients With Advanced Liposarcoma or Advanced Solid Tumors

NCT04785196Liposarcoma, Advanced Solid Tumor

DrugsAPG-115·Toripalimab

Ascentage Pharma Group Inc.

Phase 1/2

Guangzhou, Hangzhou, Shanghai

2021-05-26

Active, closed

Study of TL117 in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

NCT04843098Head and Neck Squamous Cell Carcinoma

DrugPaclitaxel

Suzhou Junde Biotechnology Co., Ltd

Phase 1/2

108

Shanghai

2021-05-26

Recruiting

Real World Study of Platinum Containing Dual Drug Chemotherapy Followed by Large Fractionated Radiotherapy Combined withTislelizumab in Stage IIIB/C-IV Non-small Cell Lung Cancer Patient

NCT07198217NSCLC, Tislelizumab, Chemotherapy, Hypofractionated Radiotherapy

DrugsTislelizumab followed by Tislelizumab·SBRT

Zibo Municipal Hospital

Phase 2

Zibo

2021-05-25

Recruiting

Relationship Between Perioperative Treatment Efficacy and The Tumor Microenvironment for Locally Advanced Resectable Gastric Cancer.

NCT04850729Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

Nanfang Hospital, Southern Medical University

Observational

169

Guangzhou

2021-05-25

Recruiting

Comparation of Endoscopic Biopsy and Postoperative Specimen for the Molecular Diagnosis of Gastric Cancer

NCT04809025Stomach Neoplasms, Endoscopy, Biopsy, Pathology

Fudan University

Observational

510

Shanghai

2021-05-24

Recruiting

A Study of BGB-11417 in Participants With Myeloid Malignancies

NCT04771130Acute Myeloid Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasm

DrugsPosaconazole·Sonrotoclax·Azacitidine

BeOne Medicines

Phase 1/2

260

Beijing, Lanzhou, Guangzhou, Shenzhen, Zhengzhou, Wuhan, Suzhou, Nanchang

2021-05-24

Active, closed

Study on the Characteristics of Non-targeted Metabolomics and EEG of Delayed Neurocognitive Recovery in Elderly Patients

NCT05105451Delayed Neurocognitive Recovery

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Observational

Shanghai

2021-05-22

Recruiting

Transcatheter Self-expandable Valve Implantation for the Treatment of Severe Native Aortic Regurgitation

NCT04864145Aortic Valve Disease

Nanjing First Hospital, Nanjing Medical University

Not applicable

210

Nanjing

2021-05-21

Recruiting

Albumin-bound Paclitaxel Combined With Liposomal Doxorubicin in the Treatment of Advanced or Unresectable Angiosarcoma

NCT04859465Angiosarcoma Metastatic

DrugsLiposomal doxorubicin·Abraxane

Sun Yat-sen University

Phase 2

Guangzhou

2021-05-21

Active, closed

An Observational Study of Long-term Peritoneal Dialysis Patients Who Eventually Develop Ultrafiltration Failure (LUFF)

NCT05721703Ultrafiltration Failure

Chinese PLA General Hospital

Observational

150

Beijing

2021-05-21

Active, closed

Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)

NCT04704934Gastric Cancer, Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

DrugsRamucirumab·Trastuzumab deruxtecan·Paclitaxel

Daiichi Sankyo

Phase 3

490

Heifi, Fuzhou, Xiamen, Guangzhou, Shijiazhuang, Harbin, Zhengzhou, Changshan

2021-05-21

Not yet open

Prediction of Postoperative Visual Acuity in Cataract Patients Using a Macular Optical Coherence Tomography-based Deep Learning Method

NCT04887909Data Collecting

Second Affiliated Hospital, Zhejiang University, School of Medicine

Observational

1,100

Hangzhou

2021-05-20

Recruiting

TATE and Pembrolizumab (MK3475) in mCRC and NSCLC

NCT04701476Colorectal Cancer; Lung Cancer

DrugsLonsurf·Regorafenib

Teclison Ltd.

Phase 2

110

2021-05-20

Active, closed

Safety and Efficacy of Subretinal Transplantation of Clinical Human Embryonic Stem Cell Derived Retinal Pigment Epitheliums in Treatment of Retinitis Pigmentosa

NCT03944239Retinitis Pigmentosa

Qi Zhou

Phase 1

Beijing

2021-05-19

Recruiting

A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)

NCT04811560Acute Leukemia

DrugBleximenib

Janssen Research & Development, LLC

Phase 1/2

420

Beijing, Changchun, Chengdu, Guangzhou, Hangzhou, Jinan, Nanchang, Nanjing

2021-05-19

Active, closed

The Kunshan Elderly Health Study

NCT05141565Cardiovascular Diseases, Diabetes Mellitus, Cancer, Cognitive Impairment

Soochow University

Observational

5,945

Kunshan

2021-05-17

Active, closed

A Trial of Nimotuzumab and Pinkiller Efficacy and Pain in Advanced Head and Neck Squamous Cell Carcinoma

NCT06879691Head and Neck Cancer

DrugsPainkiller·Nimotuzumab·Cis-platinum·Cisplatin

Biotech Pharmaceutical Co., Ltd.

Phase 4

171

Baotou

2021-05-15

Active, closed

Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC

NCT04821622Prostate Cancer

DrugsTalazoparib·Enzalutamide

Pfizer

Phase 3

599

Hefei, Beijing, Lanzhou, Guangzhou, Zhengzhou, Wuhan, Changsha, Nanjing

2021-05-12

Active, closed

Perioperative Toripalimab (JS001) Combined With Neoadjuvant Chemotherapy in Patients With Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma

NCT04848753Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma

Shanghai Junshi Bioscience Co., Ltd.

Phase 3

663

Bengbu, Hefei, Jiangmen, Shenzhen, Shijiazhuang, Anyang, Xinxiang, Zhengzhou

2021-05-12

Active, closed

Nimotuzumab High-risk, Locally Advanced Squamous Cell Carcinoma of the Cervix

NCT06771596Uterine Cervical Neoplasms

DrugNimotuzumab

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Phase 2

Beijing

2021-05-12

Recruiting

Relationship Among Oral Microbiome and NLRP3 Inflammatome and Colorectal Polyps

NCT06724133Search MeSH

Limin Zhang

Observational

Shanghai

2021-05-12

Active, closed

Prepectoral and Subpectoral Implant-based Breast Reconstruction

NCT04688697Breast Carcinoma, Breast Reconstruction

Fudan University

Not applicable

300

Shanghai

2021-05-12

Recruiting

Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System

NCT03206814Hypertension,Essential, Hypertension, Uncontrolled

Istituto Auxologico Italiano

Not applicable

480

Shanghai, Jiangse

2021-05-11

Active, closed

An Observational Study to Evaluate the Real-World Clinical Management and Outcomes of ALK-Positive Advanced NSCLC Participants Treated With Alectinib

NCT04764188NSCLC

DrugAlectinib

Hoffmann-La Roche

Observational

800

Changsha, Guangzhou, Hangzhou, Hefei, Jinan, Nanjing, Nanning, Taiyuan

2021-05-10

Active, closed

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

NCT04862663Locally Advanced (Inoperable) or Metastatic Breast Cancer

DrugsCapivasertib·Ribociclib·Abemaciclib·Palbociclib

AstraZeneca

Phase 3

893

Beijing, Bengbu, Changchun, Changsha, Chengdu, Chongqing, Guangzhou, Hangzhou

2021-05-10

Recruiting

Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML

NCT04588922Hematologic Malignancies

DrugsGFH009·Azacytidine·Venclexta·Azacitidine

Sellas Life Sciences Group

Phase 1/2

160

Bengbu, Hefei, Chongqing, Guangzhou, Baoding, Zhengzhou, Suzhou, Nanchang

2021-05-10

Recruiting

A First-in-Human, JAB-8263 in Adult Patients With Advanced Tumors

NCT04686682NSCLC, SCLC, CRPC, ESCC

DrugJAB-8263

Jacobio Pharmaceuticals Co., Ltd.

Phase 1/2

152

Tianjin

2021-05-07

Recruiting

RIR and the Impact on Clinical Outcomes in Patients Undergoing PCI

NCT05131750hsCRP

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Observational

1,408

Wuhan

2021-05-06

Recruiting

Study of GC101 TIL in Brain Glioma (Soochow2)

NCT04943913Glioma

DrugTumor Infiltrating Lymphocytes

Shanghai Juncell Therapeutics

Early Phase 1

Suzhou

2021-05-06

Recruiting

Study of Tenofovir Alafenamide in HBV-Infected Pregnant Women

NCT05853718Chronic Hepatitis b, Tenofovir Alafenamide Fumarate

DrugTenofovir Alafenamide

First People's Hospital of Hangzhou

Phase 4

Hangzhou

2021-05-06

By invitation

Safety and Effectiveness Study of Dragonfly System for Degenerative Mitral Regurgitation

NCT04734756Degenerative Mitral Valve Disease

Hangzhou Valgen Medtech Co., Ltd

Not applicable

120

Hangzhou

2021-05-04

Active, closed

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy

NCT04873362Breast Cancer

DrugsTrastuzumab emtansine·Herceptin·Tecentriq·Trastuzumab

Hoffmann-La Roche

Phase 3

1,188

Chengdu, Chongqing, Guangzhou, Harbin, Shanghai, Tianjin, Wuhan, Xi'an

2021-05-04

Recruiting

Efficacy and Safety of Amphotericin B and Azoles in the Treatment of Invasive Fungal Disease

NCT06819410Invasive Fungal Disease

Sichuan Provincial People's Hospital

Observational

1,000

Chengdu

2021-05-01

Recruiting

XuanwuH Acute Ischemic Stroke Registry

NCT05208203Acute Ischemic Stroke

Xuanwu Hospital, Beijing

Observational

500

Beijing

2021-05-01

Recruiting

Fecal Microbiota Transplantation for Liver Failure

NCT05170971Liver Failure

Ningbo Medical Center Lihuili Hospital

Not applicable

Ningbo

2021-05-01

Recruiting

Allogeneic Hematopoietic Stem Cell Transplantation Cohort Study

NCT06708130Allogeneic Hematopoietic Stem Cell Transplantation

Ruijin Hospital

Observational

3,000

Shanghai

2021-05-01

Recruiting

Screening and Application Research of Early Diabetic Nephropathy Markers Based on Lipidomics.

NCT04931537Diabetic Nephropathy Type 2, Biomarker

Second Affiliated Hospital, Zhejiang University, School of Medicine

Observational

1,000

Hangzhou

2021-05-01

Recruiting

Transcatheter Mitral Valve InterventiOn Single Center Registry in CHinese Patients With Mitral Valve Disease (TORCH-M)

NCT04954404Mitral Valve Disease

Second Affiliated Hospital, Zhejiang University, School of Medicine

Not applicable

2,000

Hangzhou

2021-05-01

Recruiting

Greater-Bay-Area Healthy Aging Brain Study (GHABS)

NCT06183658Alzheimer's Disease

Shenzhen Bay Laboratory

Observational

1,400

Shenzhen

2021-05-01

Recruiting

Intrathecal Chemotherapy for Central Nervous System Metastasis in Retinoblastoma

NCT04903678Retinoblastoma, Extraocular

DrugMelphalan

Eye & ENT Hospital of Fudan University

Not applicable

Shanghai

2021-05-01

Recruiting

Acupuncture at the Sphenopalatine Ganglion in the Treatment of Moderate-to-severe Seasonal Allergic Rhinitis

NCT04815668Seasonal Allergic Rhinitis

Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Not applicable

120

Beijing

2021-05-01

Recruiting

Spinal Cord Stimulation for Parkinsonism

NCT05171205Parkinsonism

Ruijin Hospital

Not applicable

Shanghai

2021-05-01

Recruiting

Secondary Cytoreduction Followed by Chemotherapy Versus Chemotherapy Alone in Relapsed Ovarian Cancer After PARPi Maintenance Treatment: a Multicentre, Open-label, Randomised, Phase 3 Trial

NCT05607329Relapsed Ovarian Cancer

Women's Hospital School Of Medicine Zhejiang University

Not applicable

400

Hangzhou

2021-05-01

Recruiting

Immune Checkpoint Inhibitor PD-1 Antibody Combined With Chemotherapy in the Perioperative Treatment of Locally Advanced Resectable Gastric or Gastroesophageal Junction Adenocarcinoma

NCT04908566Locally Advanced Gastric Adenocarcinoma

DrugFolfirinox

Tianjin Medical University Cancer Institute and Hospital

Phase 2

124

Tianjin

2021-05

Not yet open

Neoadjuvant Toripalimab in Combination With Carboplatin and Nab-paclitaxel in Untreated Salivary Gland Malignant Neoplasms

NCT04825938Salivary Gland Malignant Neoplasms, Salivary Gland Tumors

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Phase 2

Guangzhou

2021-04-30

Active, closed

Phase III Study ：SHR6390/Placebo Combined With Endocrine Therapy for the Adjuvant Treatment of Hormone Receptor Positive,Human Epidermal Receptor 2 Negative

NCT04842617Hormone Receptor Positive,Human Epidermal Receptor 2 Negative, Node-positive, High Risk, Early Stage，Female Breast Cancer

DrugDalpiciclib

Jiangsu HengRui Medicine Co., Ltd.

Phase 3

5,274

Shanghai

2021-04-30

Recruiting

Radiotherapy or Observation of Liver Metastases in Small Cell Lung Cancer

NCT05150145Radiotherapy; Complications

Guizhou Medical University

Not applicable

Guiyang

2021-04-30

Active, closed

Almonertinib Versus Placebo as Adjuvant Therapy in Resected Stage II-IIIB Non-Small Cell Lung Cancer With EGFR-sensitive Mutations

NCT04687241Non-small Cell Lung Cancer

DrugAlmonertinib

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Phase 3

192

Changchun

2021-04-30

Recruiting

Study of Pembrolizumab Combined with Chemotherapy in the First Line Therapy for R/M HNSCC in China

NCT04857164Head and Neck Squamous Cell Carcinoma

DrugPembrolizumab

Yuankai Shi

Phase 2

150

Beijing

2021-04-30

Active, closed

The GUARDIAN Pilot Trial

NCT04789733General Surgery

The Cleveland Clinic

Not applicable

Changchun

2021-04-27

Active, closed

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

NCT04784715Breast Cancer; HER2-positive; Metastatic

DrugsPertuzumab·Trastuzumab deruxtecan·Trastuzumab

AstraZeneca

Phase 3

1,157

Beijing, Changchun, Changsha, Chengdu, Chongqing, Dalian, Guangzhou, Hangzhou

2021-04-26

Active, closed

A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumab

NCT04770896Unresectable Hepatocellular Carcinoma

DrugsSorafenib·Tecentriq·Atezolizumab·Lenvatinib

Hoffmann-La Roche

Phase 3

557

Changsha, Fuzhou, Guangzhou, Hefei, Nanjing, Shanghai, Shenyang, Tianjin

2021-04-26

Recruiting

Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy

NCT04829708Limited Stage Small Cell Lung Cancer

Shandong Cancer Hospital and Institute

Phase 3

534

Jinan

2021-04-26

Recruiting

How Early Mobilization Impacts on Diaphragm Thickness in Critically Ill Children

NCT04534296Mechanical Ventilation Complication, Ventilator-induced Diaphragm Dysfunction

Children's Hospital of Fudan University

Not applicable

160

Shanghai

2021-04-26

Active, closed

TGRX-326 Chinese Phase I for Advanced Non-small Cell Lung Cancer (NSCLC)

NCT05441956Non-small Cell Lung Cancer

DrugTGRX-326

Shenzhen TargetRx Co., Ltd.

Phase 1

198

Guangzhou

2021-04-23

Recruiting

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

NCT04752722Superficial Bladder Cancer, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ, Non-muscle Invasive Bladder Cancer

DrugPhase 2

enGene, Inc.

Phase 1/2

350

2021-04-22

Recruiting

A Study of GC101 TIL in Advanced Solid Tumors (TR)

NCT04967833Advanced Solid Tumors

DrugTumor Infiltrating Lymphocytes

Shanghai Juncell Therapeutics

Early Phase 1

Shanghai

2021-04-22

Active, closed

Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)

NCT04700124Bladder Cancer

DrugsEnfortumab Vedotin·Keytruda·Gemcitabine·Cisplatin

Merck Sharp & Dohme LLC

Phase 3

808

Guangzhou, Changsha, Nanjing, Nantong, Shanghai

2021-04-21

Recruiting

Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy

NCT04852406Antithrombotic Therapy, Perioperative Care, Perioperative Outcomes

Peking University First Hospital

Not applicable

526

Beijing

2021-04-21

Active, closed

TIL Injection for the Treatment of Metastatic or Recurrent Solid Tumors

NCT06088472Solid Tumors, Adult

Grit Biotechnology

Phase 1

Xuzhou

2021-04-21

Active, closed

Pyrotinib Plus Neoadjuvant Chemotherapy in HR+/HER2-, HER4-High Breast Cancer

NCT04872985Breast Cancer, Hormone-receptor Positive Breast Cancer

DrugsDoxorubicin Hydrochloride Liposome·Epirubicin·Pyrotinib·Nab-paclitaxel

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Phase 2

140

Guangzhou

2021-04-20

Recruiting

Standard Chemotherapy Plus Moxifloxacin as First-line Treatment for Metastatic Triple-negative Breast Cancer

NCT04722978Triple Negative Breast Cancer

DrugMoxifloxacin

Sun Yat-Sen University Cancer Center

Phase 3

228

Guangzhou

2021-04-20

Recruiting

Study of the Correlation Between Preoperative Precise Biometrics, Spatial Assessment and Postoperative Visual Quality in Cataract Patients

NCT04833491Recruitment of Participants

Second Affiliated Hospital, Zhejiang University, School of Medicine

Observational

1,000

Hangzhou

2021-04-20

Active, closed

KDR2-2 Suspension Eyedrop in the Treatment of Neovascular Glaucoma (KDR-NVG) Trial

NCT04844619Neovascular Glaucoma, Neovascularization

Sun Yat-sen University

Phase 1

Guangzhou

2021-04-19

Active, closed

Gene Expression Changes of Brain Tissue in Human Temporal Lobe Epilepsy With Hippocampal Sclerosis

NCT04917939Epilepsy, Hippocampal Sclerosis

Second Affiliated Hospital, Zhejiang University, School of Medicine

Observational

Hangzhou

2021-04-19

Active, closed

Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum

NCT04589650PIK3CA-related Overgrowth Spectrum (PROS)

DrugAlpelisib

Novartis Pharmaceuticals

Phase 2

236

Beijing, Shanghai

2021-04-19

Recruiting

A Study of Maintenance DCVAC/OvCa After First-line Chemotherapy Added Standard of Care

NCT04834544Epithelial Ovarian Carcinoma, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma

Peking University Third Hospital

Phase 2

Beijing

2021-04-19

Active, closed

A Study to Evaluate Efficacy and Safety of Hepatic Resection for Liver Cancer With PVTT, HVTT or IVCTT After Initial Ate/Bev

NCT04649489Venous Thrombosis

DrugsAtezolizumab & Bevacizumab·Bevacizumab

Jia Fan

Phase 3

501

Shanghai, Beijing, Changsha, Chengdu, Fuzhou, Guangzhou, Hangzhou, Hefei

2021-04-19

Active, closed

Decitabine-primed Tandem CD19/CD20 CAR T Cells Treatment in r/r B-NHL

NCT04697940Relapsed and Refractory B-cell Non-Hodgkin's Lymphoma, Decitabine-primed Tandem CD19/CD20 CAR T Cells

DrugsFludarabine·Cyclophosphamide

Han weidong

Phase 1/2

Beijing

2021-04-15

Active, closed

A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.

NCT04680052Follicular Lymphoma, Marginal Zone Lymphoma

DrugsTafasitamab·Lenalidomide·Rituximab

Incyte Corporation

Phase 3

654

2021-04-15

By invitation

MInithoraCotomy vs Sternotomy for Multivessel Coronary Artery Bypass Grafting: A Partially Randomized Patient Preference Trial Assessing Quality of Life and Patency Outcomes

NCT04795193Coronary Artery Bypass, Off-Pump, Minimally Invasive Cardiac Surgery

Peking University Third Hospital

Not applicable

248

Beijing

2021-04-15

Active, closed

A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura

NCT04683003Thrombotic Thrombocytopenic Purpura (TTP)

DrugTAK-755

Takeda

Phase 3

Beijing, Wuhan, Suzhou, Tianjin

2021-04-14

Recruiting

Different Immunosuppressive Treatment in iMN

NCT04745728Idiopathic Membranous Nephropathy

DrugsPrednisone·Rituximab·Cyclophosphamide

Peking Union Medical College Hospital

Phase 3

200

Beijing

2021-04-14

Recruiting

A Study of GNC-039, a Tetra-specific Antibody, in Participants With Relapsed/Refractory or Metastatic Solid Tumors

NCT04794972Recurrent Glioma, Solid Tumor

Sichuan Baili Pharmaceutical Co., Ltd.

Phase 1

Beijing, Chongqing, Guangzhou, Shenzhen, Xian, Chengdu

2021-04-14

Active, closed

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

NCT04736706Carcinoma, Renal Cell

DrugsPembrolizumab/Quavonlimab·Belzutifan·Lenvatinib·Keytruda

Merck Sharp & Dohme LLC

Phase 3

1,688

Bengbu, Beijing, Chongging, Fuzhou, Xiamen, Guangzhou, Harbin, Zhengzhou

2021-04-14

Active, closed

Clinical Study of Mitoxantrone Hydrochloride Liposome Injection vs. Chidamide in Patients With Relapsed/Refractory PTCL

NCT04668690Peripheral T Cell Lymphoma

DrugsMitoxantrone Hydrochloride Liposome·Chidamide

CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Phase 3

193

Guangzhou

2021-04-13

Active, closed

Study to Assess the Safety and Efficacy of Viltolarsen in Ambulant Boys With DMD (RACER53-X)

NCT04768062Duchenne Muscular Dystrophy

DrugViltolarsen

NS Pharma, Inc.

Phase 3

Beijing, Changsha, Shanghai, Shenzhen

2021-04-13

Active, closed

A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment

NCT04576156Myelofibrosis

DrugImetelstat Sodium

Geron Corporation

Phase 3

327

2021-04-12

Recruiting

Impact of Early PCSK9 Inhibitor on Heart After Acute Myocardium Infarction

NCT04731155Early PCSK9 Inhibitor on Ventricular Remodling

Shanghai Tong Ren Hospital

Phase 4

Shanghai

2021-04-12

Active, closed

Safety and Efficacy Study of Human Umbilical Cord-Derived Mesenchymal Stem Cells(BC-U001) for Rheumatoid Arthritis

NCT04971980Rheumatoid Arthritis

DrugHUC-MSC

Beijing Baylx Biotech Co., Ltd.

Phase 1/2

Beijing

2021-04-12

Recruiting

HANGZHOU Solution in Bicuspid AS Undergoing TAVR

NCT04722796Aortic Stenosis, Aortic Stenosis With Bicuspid Valve

Second Affiliated Hospital, Zhejiang University, School of Medicine

Not applicable

508

Bengbu, Beijing, Fuzhou, Xiamen, Guangzhou, Zhengzhou, Wuhan, Changsha

2021-04-12

Recruiting

Tubeless Surgery With Impaired Pulmonary Function

NCT06848751Lung Function Decreased, Surgery

The Second Hospital of Shandong University

Not applicable

Jinan

2021-04-10

Active, closed

Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)

NCT04603495Myelofibrosis, Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis

DrugsPelabresib·Ruxolitinib

Novartis Pharmaceuticals

Phase 3

430

2021-04-09

Active, closed

Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)

NCT04662255Lymphoma, Mantle-Cell

DrugsPirtobrutinib·Ibrutinib·Acalabrutinib·Zanubrutinib

Loxo Oncology, Inc.

Phase 3

500

Hefei, Beijing, Fuzhou, Guangzhou, Luoyang, Zhengzhou, Wuhan, Yichang

2021-04-08

Recruiting

Oncologic Outcomes of Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer

NCT04527861Colorectal Cancer, Colon Cancer, Rectal Cancer

Ruijin Hospital

Not applicable

710

Lanzhou, Shenyang, Jinan, Chengdu, Hangzhou, Shanghai

2021-04-08

Recruiting

Three Cancellous Screws Versus Four Cancellous Screws for Femoral Neck Fixation

NCT04869332Femoral Neck Fractures, Internal Fixation

Peking University Third Hospital

Not applicable

290

Beijing

2021-04-08

Recruiting

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

NCT04728893Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia

DrugNemtabrutinib

Merck Sharp & Dohme LLC

Phase 2

490

Hefei, Beijing, Chongqing, Guangzhou, Liuzhou, Nanning, Zhengzhou, Wuhan

2021-04-05

Recruiting

Study on the Relationship Between Peripheral Blood miRNA and Risk and Severity of Alzheimer's Disease

NCT06442852Alzheimer Disease, MicroRNAs

Jiajie Chen

Observational

500

Wuhan

2021-04-03

Recruiting

Neoadjuvant Therapy Study Guided by Drug Screening in Vitro for Human Epidermal Growth Factor Receptor 2 (HER2) Negative Early Breast Cancer Patients

NCT04836156HER2-negative Early Breast Cancer

Peking University People's Hospital

Phase 1/2

Beijing

2021-04-02

Recruiting

Safety and Efficacy of Autologous iNSC-DAP in the Treatment of Parkinson's Disease

NCT05901818Parkinson's Disease

Xuanwu Hospital, Beijing

Phase 1

Beijing

2021-04-01

Active, closed

A Study to Evaluate Camrelizumab Plus Rivoceranib (Apatinib) as Adjuvant Therapy in Patients With Hepatocellular Carcinoma (HCC) at High Risk of Recurrence After Curative Resection or Ablation

NCT04639180Hepatocellular Carcinoma (HCC)

DrugsRivoceranib·Apatinib·Camrelizumab

Jiangsu HengRui Medicine Co., Ltd.

Phase 3

687

Chongqing, Nanjin, Guiyang, Shanghai, Tianjin

2021-04-01

Active, closed

A Phase II Study to Explore the Safety, Tolerability, and Preliminary Antitumor Activity of Sitravatinib Plus Tislelizumab or Combination With Nab-paclitaxel in Patients With Locally Recurrent or Metastatic Triple Negative Breast Cancer (TNBC)

NCT04734262Metastatic Breast Cancer

DrugsNab-paclitaxel·Tislelizumab

Fudan University

Phase 2

Shanghai

2021-04-01

Active, closed

Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

NCT04822181Non-alcoholic Steatohepatitis

DrugSemaglutide

Novo Nordisk A/S

Phase 3

1,205

Beijing, Chongqing, Foshan, Guangzhou, Shenzhen, Shijiazhuang, Changsha, Changzhou

2021-04-01

Not yet open

Neoadjuvant PDT in the Treatment of Cholangiocarcinoma

NCT04824742Cholangiocarcinoma Resectable

First Affiliated Hospital Xi'an Jiaotong University

Not applicable

Xi'an

2021-04-01

Recruiting

Predictive Value of Serum and Tissue Molecular Markers and Imaging Features in the Invasiveness and Prognosis of Pituitary Neuroendocrine Tumors

NCT06015802Pituitary Adenoma, Neuroendocrine Tumors

Sun Yat-sen University

Observational

300

Guangzhou

2021-04-01

Recruiting

Association Between Stroke and Adrenal Incidentalomas

NCT05237817Stroke, Adrenal Incidentaloma

Xuanwu Hospital, Beijing

Observational

Beijing

2021-04-01

Recruiting

A Prospective, Phase II Trial Using ctDNA to Initiate Post-operation Boost Therapy After Adjuvant Chemotherapy in TNBC

NCT04803539Breast Cancer

DrugsApatinib·Camrelizumab·Capecitabine

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Phase 2/3

260

Guandong

2021-04-01

Recruiting

This Study is a Prospective, Multi-center, Real World, Observational Study, Which Aims at Evaluating Intermediate and Long-term Efficacy of Endovascular Treatment for TASC C&D Aortoiliac Occlusive Disease.

NCT05391815Peripheral Arterial Disease

Shanghai Zhongshan Hospital

Observational

800

Shanghai

2021-04-01

Recruiting

Efficacy and Safety of Lenalidomide Plus CHOP vs CHOP in Patients With Untreated Peripheral T-Cell Lymphoma

NCT04922567Peripheral T-Cell Lymphoma, Lenalidomide, CHOP

DrugsVincristine·Doxorubicin·Prednisone·Lenalidomide

Second Affiliated Hospital, Zhejiang University, School of Medicine

Phase 2

289

Hangzhou

2021-04-01

Recruiting

Maternal Inheritance of a Pathogenic MT-ND1 Mutation Causes Mitochondrial Dysfunction and Spermatogenic Failure in Men

NCT07691827Azoospermia, Nonobstructive, Cryptozoospermia

The Third Affiliated Hospital of Guangzhou Medical University

Observational

1,200

Guangzhou

2021-04-01

Recruiting

The Safety and Efficiency of Endovascular Treatment of Acute or Subacute Thromboembolic Occlusions of Lower Extremity.

NCT04861506Thromboembolic Disease, Lower Extremity Problem, Endovascular Treatment, Safety Issues

First People's Hospital of Hangzhou

Observational

400

Hangzhou

2021-04-01

Recruiting

Thymosin-alpha 1 for Adjuvant Treatment After Radical Resection of High-risk Stage II and III Colorectal Cancer

NCT05086614Stage II Colorectal Cancer, Stage III Colorectal Cancer

DrugThymalfasin

Fudan University

Phase 3

2,500

Shanghai

2021-04-01

Active, closed

Phase II Study of Chemotherapy and PD-1 Inhibitor Combination With Autologous CIK Cell Immunotherapy to Treat Lung Cancer

NCT04836728Non-small Cell Lung Cancer Metastatic, First-line Treatment

DrugsAlbumin paclitaxel·Sintilimab·Pemetrexed·Carboplatin

Tianjin Medical University Cancer Institute and Hospital

Phase 2

156

Tianjin

2021-03-31

Active, closed

Osimertinib Monotherapy or Combination With Chemotherapy for Advanced NSCLC Concurrent EGFR and TP53 Mutations

NCT04695925Non-small Cell Carcinoma, EGFR Gene Mutation

DrugsOsimertinib·Pemetrexed·Carboplatin

Li Zhang, MD

Phase 3

294

Guangzhou, Zhanjiang

2021-03-29

Recruiting

Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature

NCT04674969Peripheral Vascular Diseases

Boston Scientific Corporation

Observational

5,000

Chaoyang, Xicheng, Chongqing, Guangzhou, Qingdao, Huangpu, Yangpu, Taiyuan

2021-03-29

Active, closed

TGRX-678 Chinese Phase I in Chronic Myelogenous Leukemia (CML) Patients

NCT05434312Chronic Myelogenous Leukemia

DrugTGRX-678

Shenzhen TargetRx Co., Ltd.

Phase 1

Beijing

2021-03-29

Recruiting

Neoadjuvant Therapy Study Guided by Drug Screening in Vitro for HER2 Positive Early Breast Cancer Patients

NCT04750122HER2-positive Early Breast Cancer

Peking University People's Hospital

Phase 1/2

Beijing

2021-03-28

Active, closed

PD-L1 Antibody Combined With CTLA-4 Antibody for Patients With Advanced Intrahepatic Cholangiocarcinoma Who Progressed After Standard Treatment

NCT04634058Cholangiocarcinoma, Intrahepatic, PD-L1, CTLA4

DrugIpilimumab N01

Shanghai Zhongshan Hospital

Phase 2

Shanghai

2021-03-26

Active, closed

Camrelizumab Combined With Apatinib Mesylate for Perioperative Treatment of Resectable Hepatocellular Carcinoma

NCT04521153Hepatocellular Carcinoma, Immunotherapy, Molecular Targeted Therapy

DrugsApatinib Mesylate·Camrelizumab

Shanghai Zhongshan Hospital

Phase 2/3

294

Shanghai

2021-03-25

Recruiting

Mi-thos® Transcatheter Mitral Valve Replacement Study

NCT04195984Mitral Valve Regurgitation

Shanghai NewMed Medical Co., Ltd.

Not applicable

122

Beijing, Shanghai, Xi’an

2021-03-25

Recruiting

Albumin-bound Paclitaxel Combined With Gemcitabine First-line Inoperable Pancreatic Cancer

NCT05035147Pancreatic Cancer

DrugsAlbumin-Bound Paclitaxel·Gemcitabine

Tianjin Medical University Cancer Institute and Hospital

Phase 4

934

Tianjin

2021-03-25

Recruiting

A Phase II Study of OsrHSA in Patients With Decompensated Cirrhotic Ascites

NCT04835480Cirrhotic Ascites

Healthgen Biotechnology Corp.

Phase 2

220

Changchun

2021-03-22

Recruiting

Efficiency and Safety of Microwave Ablation Plus Immune Checkpoint Inhibitor for Patients With Multiple Primary Lung Cancer: A Open, Multi-center, Phase II Clinical Trial

NCT05053802Multiple Primary Lung Cancer

Shanghai Pulmonary Hospital, Shanghai, China

Phase 2

146

Shanghai

2021-03-21

Recruiting

A Phase III Study to Assess the Effects of Almonertinib Following Chemoradiation in Patients With Stage III Unresectable Non-small Cell Lung Cancer

NCT04951635Non-small Cell Lung Cancer

DrugAlmonertinib

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Phase 3

150

Ji'nan

2021-03-18

Active, closed

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined With Abiraterone Acetate and Prednisone (AA-P) Versus Placebo Combined With AA-P as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer

NCT04691804Metastatic Castration-Resistant Prostate Cancer (mCRPC)

DrugFluzoparib

Jiangsu HengRui Medicine Co., Ltd.

Phase 3

496

Shanghai, Beijing, Changsha, Chengdu, Chongqing, Fuzhou, Guangzhou, Guiyang

2021-03-18

Active, closed

A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibition

NCT04654468Paroxysmal Nocturnal Hemoglobinuria

DrugCrovalimab

Hoffmann-La Roche

Phase 3

Chengdu, Guangzhou, Tianjin, Wuhan

2021-03-17

Active, closed

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

NCT04586010Relapsing Multiple Sclerosis

DrugsFenebrutinib·Teriflunomide

Hoffmann-La Roche

Phase 3

746

Beijing, Changchun, Changsha, Chengdu, Chongqing, Guangzhou, Guiyang, Kunming

2021-03-17

Active, closed

A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis

NCT04562870Myelofibrosis

DrugSelinexor

Karyopharm Therapeutics Inc

Phase 2

112

Beijing, Wuhan, Nantong, Suzhou, Changchun, Hangzhou

2021-03-17

Recruiting

A Study to Evaluate MK-1045 (CN201) in Participants With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (MK-1045-001/CN201-101)

NCT06189391Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

DrugMK-1045

MSD R&D (China) Co., Ltd.

Phase 1

100

Beijing, Xiameng, Guangzhou, Shijiazhuang, Zhengzhou, Nanchang, Changchun, Jinan

2021-03-16

Active, closed

A Study of TACE Combined With Atezolizumab Plus Bevacizumab or TACE Alone in Patients With Untreated Heaptocellular Carcionma

NCT04712643Hepatocellular Carcinoma

DrugsTecentriq·Avastin·Atezolizumab

Hoffmann-La Roche

Phase 3

342

Anhui, Beijing, Changsha, Chengdu, Chongqing, Fuzhou, Guangzhou, Hangzhou

2021-03-12

By invitation

Plasma Exosome RNA to Diagnose Prostate Cancer

NCT06604130Prostate Cancer

Xijing Hospital

Not applicable

1,600

Lanzhou, Yinchuan, Xining, Weinan, Xi'an, Xianyang, Yan’an

2021-03-12

Recruiting

Plasma exoRNA-Based Liquid Biopsy to Diagnose Clinically Significant Prostate Cancer

NCT07492927Clinically Significant Prostate Cancer

Xijing Hospital

Observational

1,700

Lanzhou, Yinchuan, Xining, Weinan, Xi'an, Xianyang, Yan’an

2021-03-12

Recruiting

Topotecan and Melphalan for Retinoblastoma

NCT04799002Retinoblastoma, Chemotherapy Effect

DrugsMelphalan·Topotecan

Sun Yat-sen University

Phase 3

Guangzhou

2021-03-11

Active, closed

Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis

NCT04562389Myelofibrosis

DrugsSelinexor·Ruxolitinib

Karyopharm Therapeutics Inc

Phase 3

353

2021-03-11

Not yet open

Precision Medicine Study on Cardiovascular Disease (PRECISE)

NCT04434911Cardiovascular Diseases

China National Center for Cardiovascular Diseases

Observational

20,000

Beijing

2021-03-10

Recruiting

Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After CABG

NCT04779008Coronary Disease

Henan Institute of Cardiovascular Epidemiology

Not applicable

210

Zhengzhou

2021-03-10

Recruiting

A Clinical Study to Evaluate Efficacy and Safety of Serplulimab（HLX10） Combined With Bevacizumab（HLX04) and Chemotherapy (XELOX) in Patients With Metastatic Colorectal Cancer (mCRC)

NCT04547166Metastatic Colorectal Cancer

DrugsHLX04·Serplulimab·Bevacizumab

Shanghai Henlius Biotech

Phase 2/3

568

Guangzhou, Hangzhou, Linyi, Shanghai

2021-03-10

Active, closed

Phase I Clinical Trial of CT0180 Cells in the Treatment of Hepatocellular Carcinoma

NCT04756648Advanced Hepatocellular Carcinoma

Zhejiang University

Phase 1

Hangzhou

2021-03-10

Recruiting

Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC

NCT04686305Locally Advanced or Metastatic Non-Small Cell Lung Cancer

DrugsVolrustomig·Rilvegostomig·Trastuzumab deruxtecan·Durvalumab

AstraZeneca

Phase 1

304

Changchun, Chengdu, Fuzhou, Shandong, Shanghai, Zhengzhou

2021-03-09

Recruiting

PM8002 in the Treatment of Patients With Advanced Solid Tumors

NCT05918445Malignant Neoplasm

DrugPumitamig

Biotheus Inc.

Phase 1/2

380

Baoji, Beijing, Changchun, Changde, Changsha, Changzhou, Chengdu, Chongqing

2021-03-09

Active, closed

Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

NCT04666038Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsIdelalisib·Truxima·Pirtobrutinib·Bendamustine

Loxo Oncology, Inc.

Phase 3

238

Beijing, Xicheng District, Lanzhou, Guangzhou, Haikou, Zhengzhou, Changsha, Xuzhou

2021-03-09

Recruiting

Serial PSMA PET for Therapy Monitoring in Clinically Significant Prostate Cancer

NCT07553780High-risk Prostate Cancer, PSMA PET, Treatment Response, Therapy Monitoring

Xijing Hospital

Observational

110

Lanzhou, Yinchuan, Xining, Weinan, Xi'an, Xianyang, Yan’an

2021-03-07

Recruiting

a Clinical Research of CD19 and CD22 Targeted Prime CAR-T Cell in Relapsed/Refractory B-ALL

NCT04781634B-ALL

Chongqing Precision Biotech Co., Ltd

Phase 1/2

Kunming

2021-03-07

Recruiting

a Clinical Research of BCMA-Targeted Prime CAR-T Cell Therapy in Relapsed/Refractory Multiple Myeloma and Plasma Cell Disease

NCT04776330Multiple Myeloma, Neoplasm, Plasma Cell, Multiple Myeloma in Relapse

Chongqing Precision Biotech Co., Ltd

Phase 1/2

Kunming

2021-03-07

Recruiting

Delayed PSMA PET/CT Imaging for Diagnosing Clinically Significant Prostate Cancer in Biopsy-Naïve Men With Suspected Prostate Cancer

NCT07531329Treatment-naive Prostate Cancer, Suspected Prostate Cancer, Molecular Imaging

Xijing Hospital

Observational

1,000

Lanzhou, Yinchuan, Xining, Weinan, Xi'an, Xianyang, Yan’an

2021-03-05

Recruiting

A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)

NCT04710576Chronic Graft-versus-host-disease

DrugAxatilimab

Syndax Pharmaceuticals

Phase 2

296

2021-03-04

Active, closed

Efficacy and Safety of Sirolimus in Active Systemic Lupus Erythematosus

NCT04582136Systemic Lupus Erythematosus

DrugsRapamycin·Sirolimus

Chinese SLE Treatment And Research Group

Phase 3

146

Beijing, Shenzhen, Zhengzhou, Nanchang, Shenyang, Kunming

2021-03-04

Recruiting

Gene Therapy for Chinese Hemophilia A

NCT04728841Hemophilia A, Gene Therapy

Institute of Hematology & Blood Diseases Hospital, China

Not applicable

Tianjin

2021-03-04

Recruiting

Toripalimab Plus Surgery vs Surgery Alone for Resectable Recurrent Nasopharyngeal Carcinoma

NCT04778956Nasopharyngeal Carcinoma, PD-1, Surgery

DrugToripalimab

Sun Yat-sen University

Phase 3

218

Guangzhou, Zhongshan, Nanchang

2021-03-03

Recruiting

China Amyotrophic Lateral Sclerosis Registry of Patients With Traditional Chinese Medicine

NCT04885374Amyotrophic Lateral Sclerosis

Dongzhimen Hospital, Beijing

Observational

2,000

Beijing

2021-03-01

Recruiting

Evaluating Omitting of Internal Mammary Irradiation Among Early Stage Intermediate Risk (N1) Breast Cancer

NCT04517266Breast Cancer

Ruijin Hospital

Not applicable

214

Shanghai

2021-03-01

Recruiting

Psychological Screening and Nursing of Twin Pregnancy

NCT05182541Twin; Complicating Pregnancy, Psychology

Shengjing Hospital

Not applicable

100

Shenyang

2021-03-01

Active, closed

Study of Efficacy and Safety of Inclisiran in Asian Participants With Atherosclerotic Cardiovascular Disease (ASCVD) or ASCVD High Risk and Elevated Low Density Lipoprotein Cholesterol (LDL-C)

NCT04765657Hypercholesterolemia

DrugsInclisiran sodium·Inclisiran

Novartis Pharmaceuticals

Phase 3

345

Lanzhou, Foshan, Guangzhou, Shijiazhuang, Baotou, Hohhot, Nanjing, Nantong

2021-03-01

By invitation

Multimodal Artificial Intelligence for Detecting the Psychological State of Cancer Patients

NCT07751757Neoplasm

Chinese PLA General Hospital

Observational

1,500

Beijing

2021-03-01

Active, closed

Neoadjuvant PD-1 Inhibitor (Sintilimab), Anlotinib Combined With Chemotherapy in Resectable Stage IIA-IIIB NSCLC

NCT05400070Sintilimab, Lung Cancer, Anlotinib, Chemotherapy

DrugsD1·Anlotinib·Sintilimab

Tang-Du Hospital

Phase 2

Xi'an

2021-03-01

Not yet open

Early Recurrent Nasopharyngeal Cancer: the Effect of Surgery vs IMRT

NCT04215510Recurrent Nasopharyngeal Carcinoma

Eye & ENT Hospital of Fudan University

Phase 3

286

Fuzhou, Nanchang, Shanghai

2021-03-01

Recruiting

An Observational Study on the Safety and Efficacy of Immunotherapy Combined With Concurrent Chemoradiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma

NCT07080437Esophageal Squamous Cell Carcinoma (ESCC)

Three Gorges Hospital of Chongqing University

Observational

Chongqing

2021-03-01

Recruiting

Carilizumab and Albumin Paclitaxel for Second-line Treatment of Advanced Gastric Cancer

NCT07320586Gastric Cancer, Second-line Therapy

DrugsCamrelizumab·Nab-paclitaxel

Shandong Tumor Hospital

Phase 2

Jinan

2021-03-01

Not yet open

Total Robotic Versus Robotic Assisted Distal Gastrectomy for Gastric Cancer

NCT04795063Gastric Cancer, Robotic Gastrectomy

Fujian Medical University

Not applicable

160

Fuzhou

2021-03-01

Recruiting

The Effect of Sirolimus on Immunizations During the Treatment of Kaposiform Hemangioendothelioma

NCT05351216Kaposiform Hemangioendothelioma

Children's Hospital of Fudan University

Observational

174

Shanghai

2021-03-01

Recruiting

A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy

NCT04478292Hepatoblastoma

DrugsSodium Thiosulfate·Irinotecan

Shanghai Children's Medical Center

Phase 3

330

Shanghai

2021-03-01

Recruiting

Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction

NCT06069232Aortic Valve Disease

Sun Yat-sen University

Observational

2,000

Guangzhou, Jieyang, Shantou, Shenzhen, Zhanjiang, Zhongshan

2021-03-01

Recruiting

The Study of Electrical Acupuncture Stimulation Therapy for Postprostatectomy Incontinence

NCT04972669Postprostatectomy Incontinence

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Not applicable

110

Nanjing

2021-03-01

Recruiting

Risk Factors for Colonization or Infection With Carbapenem-Resistant Enterobacteriaceae in Children

NCT04535661Carbapenem-Resistant Enterobacteriaceae Infection

Children's Hospital of Fudan University

Observational

536

Shanghai

2021-03-01

Recruiting

Neoadjuvant SHR-1210 Plus Apatinib for Resectable Stage III-IV Acral Melanoma

NCT04331093Acral Melanoma

DrugsApatinib·Camrelizumab

Di Wu

Phase 2

Changchun

2021-03-01

Recruiting

A Study on Treatment for Patients With BRAFV600E Mutant Metastatic Colorectal Cancer (mCRC)

NCT06749015Metastatic Colorectal Cancer, BRAF V600 Mutation

Fudan University

Observational

100

Shanghai

2021-03-01

Recruiting

Neoadjuvant Radiation in Locally Advanced Breast Cancer

NCT05479409Breast Neoplasms

Fudan University

Phase 2

Shanghai

2021-03-01

Recruiting

Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis

NCT04847752Ischemic Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis)

DrugsEvolocumab·Alirocumab·Biweekly·Dabigatran

Tongji Hospital

Observational

1,000

Wuhan

2021-03-01

Active, closed

CCCG-ALCL-2020 for Chinese Children and Adolescents With Newly Diagnosed High-risk ALCL

NCT04881838Pediatric Anaplastic Large Cell Lymphoma

Children's Cancer Group, China

Phase 3

172

Shanghai

2021-03-01

Recruiting

Intratumor CpG-ODN Injection Boosters Immune Killing Against in Situ Tumor Antigen Release for Advanced Solid Tumors

NCT04952272Lung Cancer, Hepatocellular Carcinoma, Solid Tumor

Second Affiliated Hospital of Guangzhou Medical University

Phase 1

Guangzhou

2021-03-01

Recruiting

China Monogenic Diabetes Registry

NCT07492004Neonatal Diabetes, Monogenic Diabetes, Maturity Onset Diabetes of the Young

Tianjin Medical University General Hospital

Observational

5,000

Tianjin

2021-02-28

Recruiting

Health ImprOvement Program of Bone in China

NCT05906147Osteoporosis

Second Xiangya Hospital of Central South University

Observational

5,000

Changsha

2021-02-27

Active, closed

Cohort Study of Airway Microecology and the Pathogenesis and Evolution of Chronic Obstructive Pulmonary Disease

NCT04849104Chronic Obstructive Pulmonary Disease

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Observational

210

Shanghai

2021-02-26

Recruiting

Multi-Centre, Prospective, Non-Interventional Study to Intensively Monitor the Safety of Sintilimab in Clinical Practice Among Chinese Patients

NCT04840355Immune Related Adverse Events, PD-1

DrugSintilimab

Guohui Li

Observational

100

Beijing

2021-02-26

Active, closed

An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions

NCT04717414Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis

DrugLuspatercept

Celgene

Phase 3

313

Guangzhou, Nanyang, Changsha, Nanjing, Nantong, Nanchang, Qingdao, Taiyuan

2021-02-25

Active, closed

Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

NCT04699188KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small-Cell Lung, Carcinoma, Colorectal, Cancer of Lung

DrugsTNO155·Opnurasib·Tislelizumab

Novartis Pharmaceuticals

Phase 1/2

344

Guangzhou, Beijing

2021-02-24

Active, closed

Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms

NCT04279847Myelofibrosis, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasm Overlap Syndrome, Myeloproliferative Neoplasm

DrugRuxolitinib

Incyte Corporation

Phase 1

140

Beijing, Guangzhou, Hangzhou, Zhengzhou

2021-02-23

Active, closed

A Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combination With Gemcitabine + Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

NCT04408638Diffuse Large B-cell Lymphoma

DrugsRituxumab·Glofitamab·Tocilizumab·Obinutuzumab

Hoffmann-La Roche

Phase 3

270

Beijing, Guangzhou, Harbin, Shanghai, Tianjin, Wuhan, Zhejiang, Zhengzhou

2021-02-23

Recruiting

68Ga-FAPI PET/CT in Malignant Tumors

NCT05034146Fibroblast Activation Protein Inhibitor, PET/CT, Malignant Neoplasm

Drug68Ga-FAPI

Zhongnan Hospital

Not applicable

500

Wuhan

2021-02-23

Active, closed

Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A

NCT04644575Hemophilia A

DrugEfanesoctocog alfa

Bioverativ, a Sanofi company

Phase 3

261

Beijing, Guangzhou, Hangzhou, Jinan, Kunming, Lanzhou, Suzhou

2021-02-23

Active, closed

Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

NCT04685135Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer

DrugsAdagrasib·Taxotere·Docetaxel

Mirati Therapeutics Inc.

Phase 3

453

Beijing, Chongqing, Fuzhou, Xiamen, Guangzhou, Liuzhou, Harbin, Xinxiang

2021-02-23

Recruiting

Neo-TACE-HAIC for High-risk BCLC A Stage HCC (NeoconceptA)

NCT04777942Hepatocellular Carcinoma

Sun Yat-sen University

Not applicable

320

Guangzhou

2021-02-20

Recruiting

Prospective Cohort Study on the Relationship Between Exosomal Peroxiredoxin 1 (PRDX1) and Postoperative Liver Metastasis

NCT07177742Colorectal Cancer, Liver Metastases From Colorectal Cancer, Pathology, Exosome

Mu-qing Yang

Observational

260

Shanghai

2021-02-15

Recruiting

Impact of Remimazolam on Prognosis After Bladder Cancer Surgery

NCT04532606Benzodiazepines, Bladder Cancer, Delirium, Surgery

DrugsRemimazolam·Propofol

Peking University First Hospital

Phase 4

1,128

Beijing, Beijin, Guiyang, Nanjing, Shanghai

2021-02-05

Not yet open

Inetetamab Plus Rapamycin and Chemotherapy for HER2+ Metastatic Breast Cancer With Abnormal Activation of PAM Pathway

NCT04736589Breast Cancer

DrugsInetetamab·Rapamycin·Pyrotinib

Peking Union Medical College

Phase 3

270

Beijing

2021-02-02

Active, closed

HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

NCT04619004Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor

DrugPatritumab deruxtecan

Daiichi Sankyo

Phase 2

277

Beijing, Changchun, Chengdu, Guangzhou, Hangzhou, Harbin, Nanjing, Shanghai

2021-02-02

Recruiting

Clinical Efficacy of Adjuvant Chemotherapy in Patients With Locally Advanced Cervical Cancer Who Did Not Meet the NCCN Guidelines for Adjuvant Treatment After NACT Combined With Surgery

NCT04733820Uterine Cervical Neoplasms, Cervical Cancer

Huazhong University of Science and Technology

Phase 3

340

Wuhan

2021-02-01

Active, closed

A Study of Endovascular Treatment of Femoropopliteal Arterial Occlusive Lesion With Drug-Coated Balloon

NCT04826705Drug-coated Balloon, Femoropopliteal Artery Occlusion, Angioplasty

Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology

Observational

2,000

Wuhan, Beijing, Chengdu, Hangzhou, Qingdao, Shanghai, Suzhou

2021-02-01

Recruiting

MR-linac Guided Ultra-hypofractionated RT for Prostate Cancer (SMART-P01 and SMART-P02)

NCT05183074Prostate Cancer, Radiotherapy Side Effect, Magnetic Resonance-linac, Stereotactic Ablative RT

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Not applicable

Beijing

2021-02-01

Recruiting

COVID-2019 Vaccine Immune Response Base on Single Cell Multi-Omics

NCT04871932Immune System and Related Disorders

RenJi Hospital

Observational

Shanghai

2021-02-01

Recruiting

Research on the Mechanism Affecting Progression of Bronchiectasis

NCT05731427Bronchiectasis

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Observational

150

Guiyang, Wuhan, Yichang

2021-02-01

Recruiting

Protective Effect of CoQ10 Against Negative Inflammatory Response and Organ Dysfunction in Cardiovascular Surgery (PANDA V)

NCT04444349Cardiovascular Disease

DrugUbiquinone

Nanjing Medical University

Not applicable

500

Beijing, Guangzhou, Nanjing, Chengdu

2021-02-01

Recruiting

Raman Spectroscopy Diagnosis of Kidney Diseases

NCT06760845IgA Nephropathy (IgAN), Membranous Nephropathy, Diabetic Nephropathy, Focal Segmental Glomerulosclerosis (FSGS)

Zunsong Wang

Observational

200

Jinan

2021-02-01

Active, closed

Paclitaxel-coated Balloon for Treatment of De-novo Non-complex Coronary Artery Lesions

NCT04561739De Novo Stenosis, Coronary Artery Disease

Xijing Hospital

Not applicable

2,272

Xi'an

2021-02-01

Active, closed

A Trial of AK112 (PD1/VEGF Bispecific) in Combination With Chemotherapy in Patients With NSCLC

NCT04736823NSCLC

DrugsIvonescimab·Pemetrexed·Docetaxel·Paclitaxel

Akeso

Phase 2

265

Guanzhou

2021-02-01

Recruiting

A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT04634552Hematological Malignancies

DrugTalquetamab

Janssen Research & Development, LLC

Phase 2

510

Beijing, Guangzhou, Hangzhou, Suzhou, Tianjin, Xi'an

2021-02-01

Recruiting

Alpha-Ketoglutarate and Abdominal Aortic Aneurysm Progression and Rupture

NCT04723888Patients With an Abdominal Aortic Aneurysm of 39-49 mm in Diameter

RenJi Hospital

Not applicable

300

Shanghai

2021-02-01

Recruiting

Ticagrelor With Low-dose Versus Regular Aspirin in Patients With Acute Coronary Syndrome (ACS) at High-Risk for Ischemia After Percutaneous Coronary Intervention

NCT04240834Acute Coronary Syndrome, Interventional Cardiology

DrugsTicagrelor·Aspirin

Fu Wai Hospital, Beijing, China

Phase 4

1,220

Beijing

2021-02-01

Recruiting

Establishment of a Cohort of Patients With Sepsis-associated Encephalopathy (SAE)

NCT04230447Sepsis-Associated Encephalopathy

Yi Li, MD

Observational

3,000

Beijing

2021-02-01

Recruiting

Safety and Efficacy of Stereotactic Aspiration Plus Urokinase in Deep Intracerebral Hemorrhage Evacuation

NCT04686877Treatment of Spontaneous Intracerebral Hemorrhage

First Affiliated Hospital of Fujian Medical University

Not applicable

400

Fuzhou

2021-01-31

Recruiting

Lymphadenectomy in Early Ovarian Cancer

NCT04710797Ovarian Cancer, Lymphadenectomy

Sun Yat-sen University

Not applicable

656

Guangzhou

2021-01-31

Recruiting

Clinical Treatment of Transcranial Direct Current Stimulation in Older Adolescents With Amblyopia

NCT06760910Amblyopia

Tianjin Eye Hospital

Not applicable

Tianjin

2021-01-30

Recruiting

Phase II Trial of Consolidative Thoracic Radiotherapy for ES-SCLC After Standard Care of Chemo-immunotherapy

NCT05552846Small-cell Lung Cancer

Ruijin Hospital

Not applicable

104

Shanghai

2021-01-30

Active, closed

A 1/2 Phase Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of ASKB589 in Patients With Locally Advanced or Metastatic Solid Tumors

NCT04632108Malignant Solid Tumor

DrugASKB589

Jiangsu Aosaikang Pharmaceutical Co., Ltd.

Phase 1/2

199

Beijing, Linyi

2021-01-28

Active, closed

A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease

NCT04711252ER-Positive HER2-Negative Breast Cancer

DrugsCamizestrant·Anastrozole·Palbociclib

AstraZeneca

Phase 3

1,371

Baoding, Beijing, Bengbu, Changchun, Changsha, Chengdu, Chongqing, Dalian

2021-01-28

Recruiting

Morning Versus Bedtime Dosing of Antihypertensive Medication

NCT05089448Hypertension, Blood Pressure, Drug Use

Yan Li

Phase 4

300

Shanghai

2021-01-28

Active, closed

Intracorporeal Anastomosis Versus Extracorporeal Anastomosis for Left Colon Cancer

NCT04201717Colon Cancer

Jilin University

Not applicable

350

Changchun, Beijing, Chongqing, Guangzhou, Shanghai, Shenyang

2021-01-27

Recruiting

Washed Microbiota Transplantation for the Treatment of Oncotherapy-Related Intestinal Complications

NCT04721041Intestinal Complications, Cancer

The Second Hospital of Nanjing Medical University

Not applicable

200

Nanjing

2021-01-26

Active, closed

Neoadjuvant Sintilimab in Combination With Carboplatin and Nab-paclitaxel in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma

NCT04718415Oral Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Phase 2

Guangzhou, Guanzhou

2021-01-23

Active, closed

Super Hypofractionated Irradiation for Whole Breast Treatment

NCT04926766Breast Cancer

Ruijin Hospital

Not applicable

217

Shanghai

2021-01-23

Recruiting

Effects of Lifestyle Intervention on Childhood Outcomes in LGA Infants

NCT04661449Childhood Overweight

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Not applicable

138

Shanghai

2021-01-22

Recruiting

Study of Larotinib in Unresectable Advanced or Recurrent Esophageal Cancer

NCT04415853Esophageal Cancer

Sunshine Lake Pharma Co., Ltd.

Phase 3

416

Beijing

2021-01-21

Active, closed

Adjuvant Regional Nodal Radiation Therapy for One Week in Breast Cancer

NCT04509648Breast Cancer

Ruijin Hospital

Not applicable

197

Shanghai

2021-01-21

Recruiting

Assessment of Pancreatic Physiological and Pathological Characteristics Based on Spectral CT

NCT06510036Diagnose Disease

Yu Shi

Observational

1,500

Shenyang

2021-01-21

Recruiting

Multicenter Study on Laparoscopic Total Gastrectomy for Advanced Gastric Cancer

NCT04710758Stomach Neoplasms

Shanghai Zhongshan Hospital

Not applicable

1,018

Shanghai

2021-01-20

Active, closed

Phase II-III Clinical Trial of PD1 Antibody (Toripalimab), Lenvatinib and GEMOX Neoadjuvant Treatment for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors

NCT04669496Intrahepatic Cholangiocarcinoma, PD1 Antibody, Lenvatinib, Gemox Chemotherapy

Shanghai Zhongshan Hospital

Phase 2/3

178

Shanghai

2021-01-20

Active, closed

Study Assessing the Efficacy and Safety of Treatment With Alpelisib Plus Fulvestrant Versus Placebo Plus Fulvestrant in Chinese Men and Postmenopausal Women With Advanced Breast Cancer

NCT04544189Breast Neoplasms

DrugsAlpelisib·Fulvestrant

Novartis Pharmaceuticals

Phase 2

Hefei, Guangzhou, Shijiazhuang, Harbin, Zhengzhou, Wuhan, Changsha, Nanjing

2021-01-20

Active, closed

PrizValve® Transcatheter Aortic Valve Replacement Study

NCT04836897Aortic Valve Stenosis

Shanghai NewMed Medical Co., Ltd.

Not applicable

120

Sichuan

2021-01-19

Active, closed

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

NCT04589845Solid Tumors

DrugsCamonsertib·Belvarafenib·Pralsetinib·Divarasib

Hoffmann-La Roche

Phase 2

920

Beijing, Chengdu, Shanghai, Tianjin, Xi'an

2021-01-18

Recruiting

A Predictive Tool for Predicting Adverse Outcomes in Acute Pulmonary Embolism Patients Using CTPA.

NCT05098769Pulmonary Embolism and Thrombosis, Deterioration, Clinical

Shengjing Hospital

Observational

300

Shenyang

2021-01-18

Recruiting

Randomized Study in Children and Adolescents With Migraine: Acute Treatment

NCT04649242Pediatric Migraine

Pfizer

Phase 3

2,100

Bengbu, Hefei, Beijing, Chongqing, Lanzhou, Shenzhen, Haikou, Shijiazhuang

2021-01-15

Not yet open

LMP1 CAR-T for Patients With LMP1 Positive Infectious Diseases and Hematological Malignancies

NCT04657965Infectious Diseases, Hematological Malignancies

Zhejiang University

Early Phase 1

144

Hangzhou

2021-01-15

Recruiting

Efficacy and Safety of Fecal Microbiota Transplantation

NCT04706611Fecal Microbiota Transplantation

Guangzhou First People's Hospital

Not applicable

300

Guangzhou

2021-01-15

Not yet open

NKG2D CAR-T Cell Therapy for Patients With Relapsed and/or Refractory Acute Myeloid Leukemia

NCT04658004Acute Myeloid Leukemia

Zhejiang University

Early Phase 1

Hangzhou

2021-01-15

Recruiting

Conversion Therapy of RAS/BRAF Wild-Type Colorectal Cancer Patients With Initially Unresectable Liver Metastases

NCT04687631Colorectal Cancer, Liver Metastases

DrugsMFOLFOXIRI·Cetuximab·Bevacizumab

Fudan University

Phase 3

508

Shanghai

2021-01-14

Recruiting

Oxaliplatin Combined With S-1(SOX) Neoadjuvant Chemotherapy for Different Cycles in Patients With Gastric Cancer

NCT04483076Gastric Cancer, Chemotherapy Effect

Chinese PLA General Hospital

Phase 3

524

Beijing

2021-01-13

Recruiting

Rituximab, Lenalidomide Combined With Methotrexate and Temozolomide For Primary Central Nervous System Lymphoma

NCT04737889Primary Central Nervous System Lymphoma

DrugsTemozolomide·Methotrexate·Lenalidomide·Rituximab

Henan Cancer Hospital

Phase 2

Zhengzhou

2021-01-13

Active, closed

CD19-targeted CAR T Cells for Relapsed and Refractory (R/R) Mantle Cell Lymphoma

NCT04718883Mantle Cell Lymphoma

Shanghai Ming Ju Biotechnology Co., Ltd.

Phase 2

Beijing, Fuzhou, Guanzhou, Zhengzhou, Nanjing, Shanghai, Tianjin, Hangzhou

2021-01-13

Recruiting

Mesogastrium Metastasis in Colon Cancer

NCT04980287Colon Cancer

Jichao Qin

Observational

Wuhan

2021-01-12

Recruiting

ECMO Treatment of Children in China in the Past 10 Years

NCT04709432Extracorporeal Membrane Oxygenation, Child, Only

Children's Hospital of Fudan University

Observational

500

Shanghai

2021-01-11

Recruiting

The Efficacy of Lymph Node Dissection for Stage IIICr of Cervical Cancer(CQGOG0103)

NCT04555226Cervical Cancer

Chongqing University Cancer Hospital

Not applicable

452

Chongqing

2021-01-11

Recruiting

China Longitudinal Aging and Cognitive Impairment Study

NCT05468905Aging, Mild Cognitive Impairment, Alzheimer Disease, Neurodegeneration

Second Affiliated Hospital, Zhejiang University, School of Medicine

Observational

4,000

Hangzhou, Lishui

2021-01-10

Active, closed

Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)

NCT04634877Endometrial Neoplasms

DrugsDocetaxel·Keytruda·Paclitaxel·Cisplatin

Merck Sharp & Dohme LLC

Phase 3

990

Hefei, Beijing, Chongqing, Xiamen, Guangzhou, Nanning, Harbin, Wuhan

2021-01-10

Recruiting

Quinoa Improves Glycolipid Metabolism and Glucose Fluctuation Based on β-Cell Function in Early-stage Type 2 Diabetes

NCT07329231Type 2 Diabetes Mellitus (T2DM)

Qilu Hospital of Shandong University

Not applicable

Jinan

2021-01-10

Active, closed

Niraparib for the Neoadjuvant Treatment of Unresectable Ovarian Cancer

NCT04507841Ovarian Cancer

DrugNiraparib

Tongji Hospital

Phase 2

Wuhan

2021-01-08

Active, closed

A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL

NCT04521231B Cell Precursor Acute Lymphoblastic Leukemia

DrugBlinatumomab

Amgen

Phase 1/2

181

Beijing, Fuzhou, Guangzhou, Zhengzhou, Wuhan, Suzhou, Qingdao, Xi’an

2021-01-04

Recruiting

Study on the Diagnostic Efficacy of ICL Selection and Prediction Depth Model Based on Eye Images

NCT06669728Posterior Chamber Phakic Intraocular Lens, Vault, Deep Neural Network, Myopia

Second Affiliated Hospital of Nanchang University

Observational

326

Nanchang

2021-01-02

Recruiting

A Prospective, Two-center, Single Arm Phase II Clinical Study to Evaluate Safety and Effectiveness of Ablation Therapy in the Treatment of Lung Cancer Presenting as Ground-glass Nodules

NCT04905056Progression

Shanghai Zhongshan Hospital

Phase 2

120

Shanghai

2021-01-01

Recruiting

The Application of Artificial Intelligence in Wrist and Hand Joint Ultrasound

NCT06883669Education, Joint Diseases

West China Hospital

Observational

500

Chengdu

2021-01-01

Recruiting

Single Arm Phase II Study of Fractionated Stereotatic Radiation Therapy (FSRT) for Bone Metastases in Breast Cancer

NCT04947280Bone Metastases, Breast Cancer

Fudan University

Phase 1/2

120

Shanghai

2021-01-01

Recruiting

Multi-points and Full-thickness Biopsy in the Diagnosis of cCR After Neoadjuvant Therapy for Rectal Cancer

NCT04743102Rectal Cancer, Neoadjuvant Therapy, Complete Remission, Metastasis

Beijing Chao Yang Hospital

Not applicable

260

Beijing

2021-01-01

By invitation

Plasma Exosomes Reveal the Efficacy of Targeted Therapy in Patients With EGFR Mutation in Lung Adenocarcinoma

NCT06730477Lung Adenocarcinoma, EGFR Activating Mutation

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Observational

500

Wuhan

2021-01-01

Recruiting

A Phase III Study Comparing Total and Partial Omentectomy for Patients With Advanced Gastric Cancer

NCT04843215Gastric Cancer

Tianjin Medical University Cancer Institute and Hospital

Not applicable

950

Tianjin

2021-01-01

Recruiting

Genotype-Phenotype Correlations in Patients With Alport Syndrome

NCT04947813Alport Syndrome

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Observational

8,165

Shanghai

2021-01-01

Recruiting

Early Antiplatelet Therapy After Hemorrhagic Infarction in Acute Ischemic Stroke Treated With Intravenous Thrombolysis (HITs)

NCT04624295Antiplatelet Therapy, Hemorrhagic Infarction

Second Affiliated Hospital, Zhejiang University, School of Medicine

Phase 4

294

Hangzhou

2021-01-01

Recruiting

Clinical Research on a Novel Deep-learning Based System in Mediastinal Endoscopic Ultrasound Scanning

NCT05792280Mediastinum Disease

The Third Xiangya Hospital of Central South University

Not applicable

180

Changsha

2021-01-01

Recruiting

Long Term Health Cohort of Premature Infants

NCT05017389Preterm

Shanghai Children's Medical Center

Observational

1,200

Shanghai

2021-01-01

Recruiting

Clinical Study of Individualized Vancomycin Dosing Based on Population PK Model

NCT06161870Severe Infection

Central South University

Phase 4

112

Changsha

2021-01-01

Recruiting

Antiepileptic Drugs in Elderly Patients

NCT05459597Seizure, Epileptic

Wei Zhao

Observational

500

Jinan

2021-01-01

Recruiting

Multi-Omics Inflammatory Phenotype for ABPA Recurrence Risk Prediction

NCT07611838Allergic Bronchopulmonary Aspergillosis (ABPA), Machine Learning, Multi-omics, Multicenter Study

Qianfoshan Hospital

Observational

300

Jinan

2021-01-01

Active, closed

PD-1 Antibody Following Preoperative Chemoradiotherapy for Locally Advanced pMMR/MSS Rectal Cancer

NCT04833387Colorectal Carcinoma

Sun Yat-sen University

Phase 2

Guangzhou

2021-01-01

Recruiting

Clinical Cohort Study in Patients With Different Subtypes of Primary Sjogren Syndrome Related Dry Eye

NCT05605314Dry Eye

Peking University Third Hospital

Observational

500

Beijing

2021-01-01

Not yet open

Clinical Study on the Safety and Effectiveness of NK Cells/Combined Monoclonal Antibodies in the Treatment of Hematological Malignancies

NCT04662788Hematological Malignancies

Zhejiang University

Early Phase 1

Hangzhou

2021-01-01

Recruiting

Biologics for Stricturing Crohn's Diseases

NCT05645055The Efficacy of Biologics for Stricturing Crohn's Diseases

Jinling Hospital, China

Observational

200

Nanjing

2021-01-01

Recruiting

Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions.

NCT04688736Allergic Transfusion Reaction

DrugChlorpheniramine

Institute of Hematology & Blood Diseases Hospital, China

Phase 2

6,642

Hefei, Zhoukou, Tai’an, Tianjin

2021-01-01

Recruiting

Effect of NST Whole-course Nutritional Management on Nutritional Status and Adverse Reactions in Esophageal Cancer

NCT05800054Esophageal Neoplasms, Adverse Drug Event

DrugsDocetaxel·Cisplatin

The First Affiliated Hospital with Nanjing Medical University

Not applicable

210

Nanjing

2021-01-01

Recruiting

HAIC Combined With Lenvatinib and PD-1 Inhibitor in Infiltrative Hepatocellular Carcinoma

NCT06333561Hepatocellular Carcinoma, Lenvatinib, PD-1 Inhibitor, Hepatic Arterial Infusion Chemotherapy

DrugsCamrelizumab·Toripalimab·Sintilimab·Lenvatinib

Sun Yat-sen University

Observational

300

Beijing

2021-01-01

By invitation

The Therapeutic Effect of Immunotherapy in Patients With Advanced Lung Squamous Carcinoma

NCT06647836Squamous Cell Lung Cancer

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Observational

1,000

Wuhan

2021-01-01

Recruiting

Locoregional Therapy Combined With Bevacizumab and PD1/L1 Inhibitor in Advanced Hepatocellular Carcinoma

NCT06323382Advanced Hepatocellular Carcinoma, Anti-PD1/PDL1 Antibody, Bevacizumab

DrugsCamrelizumab·Atezolizumab·Toripalimab·Sintilimab

Sun Yat-sen University

Observational

240

Beijing

2021-01-01

Recruiting

Engineered TILs/CAR-TILs to Treat Advanced Solid Tumors

NCT04842812Liver Cancer, Lung Cancer, Breast Cancer, Colo-rectal Cancer

Second Affiliated Hospital of Guangzhou Medical University

Phase 1

Guangzhou

2021-01-01

Recruiting

Study of the Effect of Vedolizumab on Intestinal Microecological Changes and Its Efficacy in the Treatment of Ulcerative Colitis

NCT05481619Ulcerative Colitis

DrugVedolizumab

Second Affiliated Hospital, Zhejiang University, School of Medicine

Phase 4

Zhengzhou

2021-01-01

Active, closed

Imaging Markers of High-Risk Plaque Phenotype for Predicting Post-PCI Outcomes

NCT07117084Coronary Artery Disease, Percutaneous Coronary Intervention (PCI), Atherosclerosis of Coronary Artery

Chinese Academy of Medical Sciences, Fuwai Hospital

Observational

2,000

Beijing, Tai’an, Weifang

2021-01-01

Recruiting

Postoperative Hypoxemia Increases the Risk of Anastomotic Leak After Radical Esophagectomy

NCT07309991Esophageal Carcinoma, Esophageal Adenocarcinoma, Esophagectomy, PaO2

Sun Yat-sen University

Observational

2,500

Guangzhou, Shantou, Shijiazhuang, Shanghai, Chengdu, Nanchong

2021-01-01

Recruiting

Antineoplastic Drugs in Elderly Patients

NCT05467189Cancer

DrugsLapatinib·Ceritinib·Afatinib·Crizotinib

Shandong University

Observational

500

Jinan

2021-01-01

By invitation

Intraperitoneal Immune Checkpoint Inhibitor for Malignant Ascites

NCT05745233Malignant Ascites

DrugsOpdivo·Nivolumab·Keytruda·Pembrolizumab

China Medical University Hospital

Not applicable

2021-01-01

Active, closed

Hippocampus-Avoidance Whole-Brain Radiation Therapy With Simultaneous Integrated Boost for BMs of NSCLC

NCT06557187Brain Metastases, Non-small Cell Lung Cancer

Yatian Liu

Not applicable

Nanjing

2021-01-01

Recruiting

Trametinib Combined With Everolimus and Lenvatinib for Recurrent/Refractory Advanced Solid Tumors

NCT04803318Solid Tumor, Adult, Hepatocellular Carcinoma

Second Affiliated Hospital of Guangzhou Medical University

Phase 2

100

Guangzhou

2021-01-01

Recruiting

The Association Between Radiation Dermatitis and Skin Microbiome in Breast Cancer Patients

NCT05032768Radiation Dermatitis, Skin Microbiome, Breast Cancer, Reconstructive Surgery

Fudan University

Observational

100

Shanghai

2021-01-01

Active, closed

Robotic Versus Laparoscopic Surgery for Middle and Low Rectal Cancer: a Target Trial Emulation

NCT06814093Rectal Cancer

Xu jianmin

Observational

2,702

Shanghai

2021-01-01

Recruiting

Protective Effect of Statin Against Negative Cardiovascular Remodeling and Organ Dysfunction After Acute Aortic Syndrome Surgery (PANDA III)

NCT04699279Acute Aortic Syndrome, Aortopathy

DrugRosuvastatin

Nanjing Medical University

Not applicable

300

Guangzhou, Nanjing, Qingdao, Chengdu, Beijing

2021-01-01

Recruiting

Neuroendocrine Transformation in RB1/TP53 Inactivated NSCLC

NCT06369181Neuroendocrine Carcinoma, Non-small Cell Lung Cancer, Histology Transformation

Fudan University

Observational

Shanghai

2021-01-01

Recruiting

An MRI-Based Study of Intelligent Pathological Subtyping and Grading of Renal Tumors

NCT07743749Renal Tumor, Kidney Neoplasm

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Observational

900

Beijing

2021-01-01

Recruiting

Gastric Cancer Marker Detection and Its Kit Development

NCT05010863Gastric Cancer

Second Affiliated Hospital of Wenzhou Medical University

Observational

530

Wenzhou

2021-01-01

Recruiting

To Evaluate the Safety and Effectiveness of Intrauterine Adhesion Preventer in the Prevention and Treatment of Intrauterine Adhesions, a Prospective, Multicenter, Randomized Controlled Clinical Trial

NCT07611474Intrauterine Adhesion, Intrauterine Adhesions

The Third Xiangya Hospital of Central South University

Not applicable

200

Changsha

2021-01-01

By invitation

Serum miR-455-5p and Cardiac Structure and Function Parameters in Patients With Hypertensive Heart Disease

NCT07033676Hypertension, Heart Disease

The University of Hong Kong-Shenzhen Hospital

Observational

Shenzhen

2021-01-01

Recruiting

The Role and Regulatory Mechanism of Germinal Center Immune Response in Hepatitis B Virus Infection

NCT07240350Hepatitis B Virus Infection

Nanfang Hospital, Southern Medical University

Observational

280

Guangzhou

2021-01-01

Active, closed

Optimal Ablation Strategies for Persistent AF With HF

NCT07153718Heart Failure, Persistent Atrial Fibrillation

Xu Liu

Not applicable

300

Anqing, Wuhan, Changshu, Xuzhou, Jinan, Jining, Yuhuan, Shanghai

2021-01-01

Recruiting

Nomogram for Predicting Difficult Transoral and Submental Thyroidectomy

NCT06671184Differentiated Thyroid Cancer

Shanghai 6th People's Hospital

Observational

500

Shanghai

2021-01-01

Recruiting

Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS)

NCT04777760Respiratory Distress Syndrome, Preterm Birth, Acute Respiratory Distress Syndrome, Surfactant Dysfunction

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Observational

400

Chongqing

2021-01-01

By invitation

Collect Data From Patients Receiving Standardized Anti-tuberculosis Therapy, Collect Monitoring Data, and Evaluate Treatment Efficacy and Potential Adverse Reactions.

NCT07607288Therapeutic Drug Monitoring (TDM), Tuberculosis

Beijing Chest Hospital

Observational

2,215

Beijing

2021-01-01

Recruiting

Study on Early Genetic Screening and Precise Strategy of Neonatal Critical Illness

NCT04905537Genetic Screening, Hereditary Disease, Newborn, Stillbirth

Children's Hospital of Fudan University

Observational

4,000

Shanghai

2021-01-01

Active, closed

Prehabilitation Before Liver Surgery in Older Adults

NCT07877311Preoperative Prehabilitation in Older Adults Undergoing Hepatectomy

Lining Xu

Not applicable

500

Beijing, Shenzhen, Zhengzhou, Wuhan

2021-01-01

Recruiting

Clinical Research on a Novel Deep-learning Based System in Pancreatic Endoscopic Ultrasound Scanning

NCT05792267Pancreatic Disease

The Third Xiangya Hospital of Central South University

Not applicable

200

Changsha

2021-01-01

Recruiting

Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

NCT05514769Proximal Gastric Adenocarcinoma, Gastric Cancer, Gastroesophageal Reflux Disease

Nanchong Central Hospital

Not applicable

Nanchong

2021-01-01

Recruiting

Percutaneous Electrocoagulation Versus Sclerosing Foam for Patients With Incompetent Perforating Veins

NCT04686097Incompetent Perforating Veins

Second Affiliated Hospital, Zhejiang University, School of Medicine

Not applicable

Hefei, Yantai, Shanghai, Hangzhou

2021-01-01

Active, closed

Application of in Vivo Splitting Technique in Adult Liver Transplantation

NCT06925828Liver Transplantation

Ningbo Medical Center Lihuili Hospital

Observational

500

Ningbo

2021-01-01

Recruiting

Watch and Wait in PD-1 Monoclonal Antibody Treated dMMR/MSI-H Distal Rectal Cancer

NCT04643041Rectal Cancer

Sixth Affiliated Hospital, Sun Yat-sen University

Not applicable

Guangzhou

2021-01-01

Not yet open

A Study of Humanized BCMA-targeted CAR-T Cells Therapy for Refractory/Relapsed Multiple Myeloma

NCT04670055Relapse Multiple Myeloma, Refractory Multiple Myeloma

Zhejiang University

Early Phase 1

Hangzhou

2021-01-01

Recruiting

ML-Based ABPA Recurrence Prediction and Clinical Utility

NCT07714863ABPA, Allergic Bronchopulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis (ABPA), Acute Exacerbation

Qianfoshan Hospital

Observational

200

Jinan

2021-01-01

Recruiting

Chinese DENOVO PD Registry

NCT05767151Parkinson Disease

Xiangya Hospital of Central South University

Observational

300

Changsha

2021-01-01

Recruiting

Comparison Of Percutaneous Mechanical Thrombectomy With Different Access in Treatment of Acute Deep Venous Thrombosis

NCT06124768Deep Vein Thrombosis

RenJi Hospital

Observational

210

Shanghai

2021-01-01

Not yet open

Stratified Evaluation of PDS and NACT-IDS in Ovarian Cancer (FOCUS)

NCT04515602Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma

Shanghai Gynecologic Oncology Group

Phase 3

410

Shanghai

2021-01

Active, closed

Effectiveness and Safety of Dabrafenib in Combination With Trametinib as Adjuvant Treatment for Chinese Patients With Stage III BRAF V600 Mutation-positive Melanoma After Complete Resection

NCT04666272Melanoma

DrugsDabrafenib·Trametinib

Novartis Pharmaceuticals

Observational

Fuzhou, Zhengzhou, Wuhan, Changsha, Nanjing, Kunming, Hangzhou, Beijing

2020-12-31

Not yet open

A Study of CS1-targeted CAR-T Cells Therapy for Relapsed Multiple Myeloma After BCMA CAR-T Cells Therapy

NCT04541368Relapse Multiple Myeloma

Zhejiang University

Early Phase 1

Hangzhou

2020-12-31

Recruiting

Eltrombopag for Chemotherapy-induced Thrombocytopenia

NCT04600960Chemotherapy-induced Thrombocytopenia, Eltrombopag

DrugEltrombopag

Institute of Hematology & Blood Diseases Hospital, China

Phase 2

Tianjin

2020-12-31

Recruiting

ATG Individualized Dosing Model in URD-PBSCT.

NCT06572462Cytomegalovirus Infections, Infection Reactivation, Stem Cell Transplant Complications

Chinese PLA General Hospital

Phase 2

Beijing

2020-12-31

Not yet open

Lenvatinib and Pembrolizumab in Resectable Mucosal Melanoma

NCT04622566Mucosal Melanoma, Neoadjuvant Treatment

DrugsLenvatinib, Pembrolizumab·Lenvatinib·Keytruda

Peking University Cancer Hospital & Institute

Phase 2

Beijing

2020-12-30

Recruiting

Prospective Cohort Study of Intracerebral Hemorrhage

NCT04707105Intracerebral Hemorrhage

Second Affiliated Hospital, Zhejiang University, School of Medicine

Observational

856

Hangzhou

2020-12-29

Active, closed

Guo's Subclavian Artery Reconstruction: The Prospective, Multiple Center Study of WeFlow-Tbranch Stent Graft System(GUEST Study)

NCT04765605Type B Aortic Dissection

Hangzhou Endonom Medtech Co., Ltd.

Not applicable

120

Beijing, Changsha, Chengdu, Foshan, Fuzhou, Guangzhou, Hangzhou, Hefei

2020-12-25

Recruiting

Environment, Inflammation and Metabolic Diseases Study

NCT07512609Endocrine Disease, Metabolic Disorders, Hypertension, Diabetes Mellitus

Qifu Li

Observational

8,000

Chongqing

2020-12-25

Recruiting

Clinical Trial of CNCT19 Cell Injection in the Treatment of Relapsed or Refractory Acute Lymphoblastic Leukemia

NCT04684147Relapsed or Refractory Acute Lymphoblastic Leukemia

DrugSingle of CNCT19

Juventas Cell Therapy Ltd.

Phase 2

100

Beijing, Chongqing, Guangzhou, Sanhe, Zhengzhou, Wuhan, Xuzhou, Shanghai

2020-12-24

Recruiting

Internal Microstructure of Patent Foramen Ovale Related to Stroke

NCT04686253Patent Foramen Ovale

China National Center for Cardiovascular Diseases

Observational

1,200

Beijing

2020-12-23

Recruiting

Samples Procurement for Colorectal Cancer, Gastric Cancer, and Non-malignant Disease

NCT03972956Colorectal Cancer, Gastric Cancer, Inflammatory Bowel Diseases, Gastric Ulcer

Renmin Hospital of Wuhan University

Observational

1,000

Wuhan

2020-12-23

Recruiting

Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF

NCT04597164Hepatitis B, Chronic, Acute-On-Chronic Liver Failure

Third Affiliated Hospital, Sun Yat-Sen University

Observational

200

Guangzhou

2020-12-22

Recruiting

Secukinumab Open Label Roll-over Extension Protocol

NCT04638647Autoimmunity, Inflammation

DrugSecukinumab

Novartis Pharmaceuticals

Phase 4

1,000

Hefei, Beijing, Chongqing, Xiamen, Guangzhou, Shantou, Shenzhen, Wuhan

2020-12-22

Active, closed

A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer

NCT04607421Neoplasms

DrugsEncorafenib·Zirabev·Erbitux·Xeloda

Pfizer

Phase 3

841

Beijing, Chongqing, Fuzhou, Guangzhou, Nanning, Wuhan, Changsha, Nanjing

2020-12-21

Active, closed

Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)

NCT04656652Non-small Cell Lung Cancer

DrugsDato-DXd·Docetaxel

Daiichi Sankyo

Phase 3

605

Beijing, Changsha, Hangzhou, Hangzou, Heilongjiang, Henan, Hubei, Nanjing

2020-12-21

Recruiting

A Study of AL58805 in Patients With Advanced Tumors

NCT07179081Advanced Tumors

DrugAL58805

Advenchen Laboratories Nanjing Ltd.

Phase 1

Changsha

2020-12-20

Recruiting

The Role of Skin Microecology in Diabetic Skin Lesions

NCT04916457Diabetic Foot, Diabetic Dermopathy

Nanfang Hospital, Southern Medical University

Observational

200

Guangzhou

2020-12-18

Recruiting

To Evaluate Safety and Effectiveness of Transcatheter Aortic Valve System in Patients With Severe Aortic Stenosis

NCT04893603Aortic Valve Stenosis

Chengdu Silara Meditech Inc.

Not applicable

120

Beijing

2020-12-16

Active, closed

A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

NCT04590235Neurofibromatosis 1, Neurofibroma Plexiform

DrugSelumetinib

AstraZeneca

Phase 1

Shanghai

2020-12-16

Active, closed

A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer

NCT04351555Non-Small Cell Lung Cancer

DrugsTagrisso·Osimertinib·Pemetrexed·Cisplatin

AstraZeneca

Phase 3

358

Beijing, Changsha, Chengdu, Chongqing, Guangzhou, Hangzhou, Kunming, Nanchang

2020-12-16

Active, closed

Toripalimab Combined With Gemcitabine and Cisplatin Treating Resectable Locally Advanced HNSCC

NCT04947241Locally Advanced Head and Neck Squamous Cell Carcinoma, Neoadjuvant Therapy

DrugsGemcitabine·Cisplatin

Fifth Affiliated Hospital, Sun Yat-Sen University

Phase 1

Zhuhai

2020-12-15

Active, closed

Atrasentan in Patients With IgA Nephropathy

NCT04573478IgA Nephropathy, Immunoglobulin A Nephropathy

DrugsAtrasentan·Zigakibart

Novartis Pharmaceuticals

Phase 3

404

Dongguan, Fuzhou, Baotou, Nanjing, Nantong, Shanghai, Chengdu, Ürümqi

2020-12-11

Recruiting

Function Integrity of Neck Anatomy in Thyroid Surgery

NCT04666103Thyroid Carcinoma, Thyroid Nodule (Benign), Ablation; Retina

Wuhan University

Not applicable

1,264

Wuhan

2020-12-11

Recruiting

Nomogram to Predict Breast Cancer Related Lymphedema

NCT04665882Breast Cancer, Axillary Lymph Node Dissection, Breast Cancer Related Lymphedema, Axillary Reverse Mapping

Wuhan University

Not applicable

600

Wuhan

2020-12-11

Active, closed

Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)

NCT04624204Small Cell Lung Cancer

DrugsOlaparib·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 3

672

Beijing, Chongqing, Fuzhou, Xiamen, Shenzhen, Zhengzhou, Wuhan, Changsha

2020-12-08

Active, closed

Dacomitinib in Lung Cancer With Uncommon EGFR Mutations

NCT04504071Non-small Cell Lung Cancer Metastatic, EGF-R Positive Non-Small Cell Lung Cancer

DrugDacomitinib

Shanghai Chest Hospital

Phase 2

Shanghai

2020-12-08

Active, closed

A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder

NCT04658862Urinary Bladder Neoplasms

DrugsTAR-200·Cetrelimab·Gemcitabine·Cisplatin

Janssen Research & Development, LLC

Phase 3

518

Beijing, Changchun, Changsha, Changsha Shi, Chengdu, Chongqing, Guangzhou, Hangzhou

2020-12-07

Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Chinese investigative site. Derived from ClinicalTrials.gov. Retrieved 7 November 2026. https://priyalifescience.com/clinical-trials-china?page=36

Query this register directly

GET /api/trials?country=cn&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in China and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 19,187 studies in total at the last sync on 07 Nov 2026, 03:17 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

How many clinical trials are recruiting in China?

11,790 of the 19,187 studies in this register are recruiting new participants as of the 07 Nov 2026, 03:17 UTC sync. A further 3,998 have not yet opened recruitment, 2,715 are active but closed to new participants, and 684 are enrolling by invitation only. Eligibility for any study is decided by its study team.

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Browse trials by condition

Breast Cancer (423) Advanced Solid Tumors (187) Colorectal Cancer (179) Gastric Cancer (175) Hepatocellular Carcinoma (154) Advanced Solid Tumor (153) Non-Small Cell Lung Cancer (145) Solid Tumor (142) Acute Ischemic Stroke (140) Lung Cancer (135) Non-small Cell Lung Cancer (132) Pancreatic Cancer (131) Multiple Myeloma (128) Coronary Artery Disease (122) Prostate Cancer (110)

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Browse trials by site location

Beijing (5576) Shanghai (3879) Guangzhou (3345) Hangzhou (1819) Wuhan (1343) Chengdu (1307) Nanjing (1211) Changsha (1154) Chongqing (1078) Fuzhou (1040) Tianjin (934) Zhengzhou (931) Hefei (896) Jinan (783) Changchun (639)

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and India registers.