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Priya Life Science Compound trial record
Compound · clinical trials

Anlotinib hydrochloride clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 16 trials in our China and Japan registers that name Anlotinib hydrochloride as an intervention. Synced 9 Nov 2026
16Current trials
10Recruiting now
10Lead sponsors
2Country registers
At a glance

Anlotinib hydrochloride is named as an intervention in 16 current clinical trials in our China and Japan registers. 10 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is Chia Tai Tianqing Pharmaceutical Group Co., Ltd (7). The most-studied condition is Medullary Thyroid Cancer.

How Anlotinib hydrochloride works

All drug targets →
  • Vascular endothelial growth factor receptor 2 inhibitor Inhibitor
    Target: KDR kinase insert domain receptor
    ✓ In ChEMBL and the Guide to Pharmacology
  • Vascular endothelial growth factor receptor 3 inhibitor Inhibitor
    Target: FLT4 fms related receptor tyrosine kinase 4
    ✓ In ChEMBL and the Guide to Pharmacology
  • Stem cell growth factor receptor inhibitor Inhibitor
    Target: KIT KIT proto-oncogene, receptor tyrosine kinase
    ChEMBL only
  • Platelet-derived growth factor receptor beta inhibitor Inhibitor
    Target: PDGFRB platelet derived growth factor receptor beta
    ChEMBL only
Diseases it has been tested for in clinical trials, by furthest phase
  • Alveolar soft part sarcomaPhase 3
  • Cervical carcinomaPhase 3
  • Clear cell renal carcinomaPhase 3
  • Colorectal adenocarcinomaPhase 3
  • Colorectal cancerPhase 3
  • Endometrial carcinomaPhase 3
  • Fallopian tube carcinomaPhase 3
  • Hepatocellular carcinomaPhase 3
  • LeiomyosarcomaPhase 3
  • Nasopharyngeal carcinomaPhase 3
92 diseases in all

Mechanisms and diseases from ChEMBL via the Open Targets Platform (release 26.09), ChEMBL record CHEMBL4303201, CC BY-SA 3.0. Targets checked against the IUPHAR/BPS Guide to PHARMACOLOGY (2026.3.1), ligand 9601, CC BY-SA 4.0. Trial phases are not approvals: approved uses are shown from the regulators' own records where we hold them.

Patient leaflets for Anlotinib hydrochloride

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting1063%
  • Not yet open319%
  • Active, closed319%

Trials by phase

  • Phase 2850%
  • Phase 3425%
  • Phase 416%
  • Observational16%
  • Not applicable16%
  • Phase 1/216%
01

Clinical trials of Anlotinib hydrochloride

16 trials
StudyPhaseStatusLead sponsorRegisters
Study of Anlotinib in Patients With Advanced Medullary Thyroid Carcinoma
NCT05830500 · ClinicalTrials.gov ↗ · Medullary Thyroid Cancer
Phase 4 Recruiting Chia Tai Tianqing Pharmaceutical Group Co., Ltd China
Clinical Trial Comparing TQB2868 Injection Combined With Anlotinib Hydrochloride Capsules With Placebo Combined With Chemotherapy as First-line Treatment for Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC)
NCT07165951 · ClinicalTrials.gov ↗ · Metastatic Pancreatic Ductal Adenocarcinoma
Phase 3 Recruiting Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd China
Preoperative IMRT With Anlotinib and Penpulimab for Localized Sarcoma (SPARE-01)
NCT05167994 · ClinicalTrials.gov ↗ · Sarcoma,Soft Tissue, Extremity, Trunk
Phase 2 Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences China
Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients
NCT05252078 · ClinicalTrials.gov ↗ · Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms, Esophageal Diseases
Phase 2 Recruiting Jiangxi Provincial Cancer Hospital China
XELOX Combined With Anlotinib and Penpulimab vs XELOX as Adjuvant Therapy in ctDNA Positive Gastric and Esophagogastric Junction Adenocarcinoma
NCT05494060 · ClinicalTrials.gov ↗ · Carcinoma, Gastrointestinal Diseases, Stomach Cancer
Phase 2 Recruiting The First Affiliated Hospital with Nanjing Medical University China
A Clinical Study of TQB2450 Injection Combined With Chemotherapy or Anlotinib Hydrochloride Capsule in the Treatment of Non Small Cell Lung Cancer
NCT05913089 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer
Phase 2 Recruiting Chia Tai Tianqing Pharmaceutical Group Co., Ltd China
Radiation Therapy Followed by Tislelizumab and Anlotinib Aeoadjuvant/Adjuvant Therapy for Stage II-IIIA NSCLC
NCT06379087 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
Phase 2 Recruiting Ji Yongling China
Clinical Trials of Benmelstobart Injection Combined With Anlotinib Hydrochloride Capsules in the Treatment of Advanced or Unresectable Alveolar Soft Part Sarcoma
NCT07548177 · ClinicalTrials.gov ↗ · Alveolar Soft Part Sarcoma
Phase 2 Recruiting Chia Tai Tianqing Pharmaceutical Group Co., Ltd China
Study of Anlotinib Hydrochloride Capsules in the Treatment of Locally Advanced or Metastatic Radioiodine-Refractory Differentiated Thyroid Carcinoma
NCT05994365 · ClinicalTrials.gov ↗ · Thyroid Neoplasms
Observational Recruiting Chia Tai Tianqing Pharmaceutical Group Co., Ltd China
SRT Combined With Anlotinib for the Treatment of Brain Metastases From Non-small Cell Lung Cancer
NCT06476093 · ClinicalTrials.gov ↗ · Non-Small-Cell Lung Cancer, Brain Metastases
Not applicable Recruiting The First People's Hospital of Lianyungang China
Anlotinib Hydrochloride Capsules Combined With TQB2450 in the Treatment of Endometrial Cancer
NCT06475599 · ClinicalTrials.gov ↗ · Endometrial Cancer
Phase 3 Not yet open Chia Tai Tianqing Pharmaceutical Group Co., Ltd China
Anlotinib + Benmelstobart vs Surgery for Patients With Localized Renal Cell Carcinoma Scheduled to Undergo Partial Nephrectomy
NCT07627464 · ClinicalTrials.gov ↗ · Renal Cell Carcinoma (RCC)
Phase 2 Not yet open Tianjin Medical University Cancer Institute and Hospital China
Interferon-α1b Combined With Toripalimab and Anlotinib Hydrochloride in Advanced Unresectable Melanoma
NCT05539118 · ClinicalTrials.gov ↗ · Melanoma
Phase 1/2 Not yet open Xijing Hospital China
A Phase III Clinical Trial of AK105 Injection Combined With Anlotinib Hydrochloride Capsules Versus Sorafenib in Subjects With Advanced Hepatocellular Carcinoma (HCC)
NCT04344158 · ClinicalTrials.gov ↗ · Advanced Hepatocellular Carcinoma (HCC)
Phase 3 Active, closed Chia Tai Tianqing Pharmaceutical Group Co., Ltd China
A Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy as First-line Treatment in Subjects With RAS/BRAF Wild Metastatic Colorectal Cancer
NCT04854668 · ClinicalTrials.gov ↗ · Metastatic Colorectal Cancer
Phase 3 Active, closed Chia Tai Tianqing Pharmaceutical Group Co., Ltd China, Japan
Newly Diagnosed Glioblastoma
NCT04959500 · ClinicalTrials.gov ↗ · Glioblastoma
Phase 2 Active, closed Sun Yat-sen University China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Anlotinib hydrochloride

26 conditions
Medullary Thyroid Cancer1Thyroid Neoplasms1Renal Cell Carcinoma (RCC)1Non-Small-Cell Lung Cancer1Brain Metastases1Endometrial Cancer1Glioblastoma1Metastatic Pancreatic Ductal Adenocarcinoma1Esophageal Squamous Cell Carcinoma1Esophageal Neoplasms1Esophageal Diseases1Gastrointestinal Neoplasms1
All 26 conditions
Condition (as registered)Trials
Medullary Thyroid Cancer1
Thyroid Neoplasms1
Renal Cell Carcinoma (RCC)1
Non-Small-Cell Lung Cancer1
Brain Metastases1
Endometrial Cancer1
Glioblastoma1
Metastatic Pancreatic Ductal Adenocarcinoma1
Esophageal Squamous Cell Carcinoma1
Esophageal Neoplasms1
Esophageal Diseases1
Gastrointestinal Neoplasms1
Advanced Hepatocellular Carcinoma (HCC)1
Non-Small Cell Lung Cancer1
Metastatic Colorectal Cancer1
Melanoma1
Non Small Cell Lung Cancer1
Alveolar Soft Part Sarcoma1
Sarcoma,Soft Tissue1
Extremity1
Trunk1
Anlotinib1
Carcinoma1
Gastrointestinal Diseases1
Stomach Cancer1
Gastroesophageal-junction Cancer1
05

Related compounds

06

Questions about Anlotinib hydrochloride trials

How many clinical trials are testing Anlotinib hydrochloride?

16 current trials in our China and Japan registers name Anlotinib hydrochloride as a drug or biological intervention, as of the registry sync on 9 November 2026. Completed and withdrawn studies are not counted.

Are Anlotinib hydrochloride trials recruiting patients?

Yes. 10 of the 16 trials are recruiting: 10 with sites in China. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Anlotinib hydrochloride clinical trials?

Chia Tai Tianqing Pharmaceutical Group Co., Ltd (7), Tianjin Medical University Cancer Institute and Hospital (1), The First People's Hospital of Lianyungang (1) and Sun Yat-sen University (1), among 10 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Anlotinib hydrochloride works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Anlotinib hydrochloride works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Anlotinib hydrochloride (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 9 Nov 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.