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Compound · clinical trials

Evolocumab clinical trials

Also listed in trial records as Alirocumab, PCSK9 inhibitor, Repatha, Fibrates, Conventional lipid-lowering therapy
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 12 trials in our China and USA registers that name Evolocumab as an intervention. Synced 25 Sep 2026
12Current trials
8Recruiting now
10Lead sponsors
2Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Evolocumab is named as an intervention in 12 current clinical trials in our China and USA registers. 8 are recruiting patients now. The most common phase is Phase 4. The sponsor with the most trials is General Hospital of Shenyang Military Region (2). The most-studied condition is Acute Myocardial Infarction.

Evolocumab also has an approved-drug profile on this site (FDA label data): Repatha (Evolocumab) →

Trials by status

  • Recruiting867%
  • Not yet open325%
  • Active, closed18%

Trials by phase

  • Phase 4433%
  • Not applicable433%
  • Observational217%
  • Phase 218%
  • Phase 2/318%
01

Clinical trials of Evolocumab

12 trials
StudyPhaseStatusLead sponsorRegisters
The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques
NCT03753555 · ClinicalTrials.gov ↗ · Stroke, Ischemic, Atherosclerosis, Cerebral
Phase 4 Recruiting General Hospital of Shenyang Military Region China
Impact of Early PCSK9 Inhibitor Treatment on Heart After Acute Myocardium Infarction
NCT05292404 · ClinicalTrials.gov ↗ · Acute Myocardial Infarction
Phase 4 Recruiting Shanghai Tong Ren Hospital China
CAPRA-EVO: a Randomized Serial PCCT Trial of Early Evolocumab After ACS
NCT07612774 · ClinicalTrials.gov ↗ · Coronary, Coronary Artery Disease
Phase 4 Recruiting West China Hospital China
A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
NCT07477704 · ClinicalTrials.gov ↗ · Hypercholesterolemia
Phase 2 Recruiting Regeneron Pharmaceuticals USA
Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis
NCT04847752 · ClinicalTrials.gov ↗ · Ischemic Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis)
Observational Recruiting Tongji Hospital China
Multicenter Real-World Cohort Study Evaluating the Impact of Early Intensive Lipid-Lowering Therapy on the Prognosis of Acute Coronary Syndrome Patients(ELITE-ACS)
NCT06738758 · ClinicalTrials.gov ↗ · Acute Coronary Syndromes
Observational Recruiting Yun Dai Chen China
Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome
NCT05397405 · ClinicalTrials.gov ↗ · Intracranial Artery Stenosis
Not applicable Recruiting Nanjing First Hospital, Nanjing Medical University China
Adding Evolocumab to Conventional Lipid-lowering Therapy for Hypertriglyceridemia Induced Acute Pancreatitis
NCT07388420 · ClinicalTrials.gov ↗ · Hypertriglyceridemia Induced Acute Pancreatitis
Not applicable Recruiting General Hospital of Shenyang Military Region China
PCSK9 Inhibitors in Acute Ischemic Stroke Patients Undergoing Endovascular Therapy
NCT07174375 · ClinicalTrials.gov ↗ · Acute Ischemic Stroke
Phase 2/3 Not yet open Nanfang Hospital, Southern Medical University China
Protective Effect of PCSK9 Inhibitor Against Negative Inflammatory Response and Organ Dysfunction After Coronary Artery Bypass Grafting (PANDA VIII)
NCT06730802 · ClinicalTrials.gov ↗ · Myocardial Ischaemic Syndrome, Coronary Heart Disease
Not applicable Not yet open Nanjing Medical University China
Assessing Coronary Non-Culprit Plaque Early with Start of PCSK9 Inhibitors in Acute Myocardial Infarction (ACCESS-AMI)
NCT06854523 · ClinicalTrials.gov ↗ · Acute Myocardial Infarction
Not applicable Not yet open Yun Dai Chen China
EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction
NCT05284747 · ClinicalTrials.gov ↗ · Cardiovascular Disease, Myocardial Infarction, Stroke
Phase 4 Active, closed Amgen USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Evolocumab

18 conditions
Acute Myocardial Infarction2Hypercholesterolemia1Acute Ischemic Stroke1Cardiovascular Disease1Myocardial Infarction1Stroke1Coronary Revascularization1Hypertriglyceridemia Induced Acute Pancreatitis1Coronary1Coronary Artery Disease1Intracranial Artery Stenosis1Stroke, Ischemic1
All 18 conditions
Condition (as registered)Trials
Acute Myocardial Infarction2
Hypercholesterolemia1
Acute Ischemic Stroke1
Cardiovascular Disease1
Myocardial Infarction1
Stroke1
Coronary Revascularization1
Hypertriglyceridemia Induced Acute Pancreatitis1
Coronary1
Coronary Artery Disease1
Intracranial Artery Stenosis1
Stroke, Ischemic1
Atherosclerosis, Cerebral1
Myocardial Ischaemic Syndrome1
Coronary Heart Disease1
Ischemic Stroke1
Large-Artery Atherosclerosis (Embolus/Thrombosis)1
Acute Coronary Syndromes1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
General Hospital of Shenyang Military Region2
Yun Dai Chen2
Regeneron Pharmaceuticals1
Shanghai Tong Ren Hospital1
Nanfang Hospital, Southern Medical University1
Amgen1
West China Hospital1
Nanjing First Hospital, Nanjing Medical University1
Nanjing Medical University1
Tongji Hospital1
04

By country register

RegisterTrialsRecruiting
Clinical trials in China107
Clinical trials in USA21

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Evolocumab trials

How many clinical trials are testing Evolocumab?

12 current trials in our China and USA registers name Evolocumab (also registered as PCSK9 inhibitor) as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are Evolocumab trials recruiting patients?

Yes. 8 of the 12 trials are recruiting: 7 with sites in China and 1 with sites in USA. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Evolocumab clinical trials?

General Hospital of Shenyang Military Region (2), Yun Dai Chen (2), Regeneron Pharmaceuticals (1) and Shanghai Tong Ren Hospital (1), among 10 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Evolocumab works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Evolocumab works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Evolocumab (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.