Ireland
--:--IST
Latest
Priya Life Science Clinical trial register
TrackersDrugsComparisonsAPI
Trackers› Clinical trials› Texas
Clinical trial register · United States · industry-sponsored

Clinical Trials in Texas, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

Download CSV
Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9118 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 06 Oct 2026, 03:16 UTC
9118
Studies in scope
industry-sponsored, all four open statuses
4945
Recruiting now
open to new participants
2189
Lead sponsors
across recruiting studies
Top states
California 5290 Florida 4430 Illinois 2481 Georgia 2368 Arizona 2238
Narrow the registerReset
Recruitment status
Phase
Target enrolment
to

Trials with a site in Texas

1965 of 9118 studies
Download
Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Recruiting
Study Evaluating UCART20x22 in B-Cell Non-Hodgkin Lymphoma
NCT05607420B-cell Non-Hodgkin Lymphoma (B-NHL)
Cellectis S.A.
Phase 1/2
80
Illinois, Massachusetts, New Jersey, Texas
2022-11-01
Active, closed
A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH
NCT05389449Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc.
Phase 3
80
California, Illinois, Maryland, Missouri, New York, Ohio, Texas
2022-10-28
Recruiting
A First-in-human Study of IBI343 in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors
NCT05458219Locally Advanced Unresectable or Metastatic Solid Tumors
Innovent Biologics (Suzhou) Co. Ltd.
Phase 1
470
Texas
2022-10-26
Active, closed
BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors
NCT05120271Hepatocellular Carcinoma, Squamous Cell Carcinoma of the Lung, Merkel Cell Carcinoma, Myxoid/Round Cell Liposarcoma
Sotio Biotech Inc.
Phase 1/2
7
California, Texas, Washington, Wisconsin
2022-10-26
Active, closed
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma
NCT05169515Non-Hodgkin Lymphoma
Hoffmann-La Roche
Phase 1
121
California, Colorado, Florida, Illinois, North Carolina, Texas
2022-10-26
Recruiting
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
NCT05208762Carcinoma, Non-Small-Cell Lung, Squamous Cell Carcinoma of the Head and Neck, Esophageal Squamous Cell Carcinoma, Triple Negative Breast Neoplasms
Seagen, a wholly owned subsidiary of Pfizer
Phase 1
714
Alabama, California, Iowa, Michigan, Ohio, Texas, Utah, Virginia
2022-10-25
Active, closed
The MONARCH Case Series Study: SPRINT® Peripheral Nerve Stimulation for the Treatment of Head Pain
NCT05491915Cervicogenic Headache, Occipital Neuralgia
SPR Therapeutics, Inc.
Not applicable
50
California, Massachusetts, Minnesota, North Carolina, Texas, Utah
2022-10-24
Recruiting
International Multicentric Observational Study to Characterize Subpopulations of Patients With Autism Spectrum Disorder
NCT05590715Autism Spectrum Disorder
Stalicla SA
Observational
1,500
Arizona, California, Florida, Illinois, Missouri, New Mexico, Texas, Utah
2022-10-13
Active, closed
Clinical Trial on Agitation in Alzheimer's Dementia
NCT05543681Alzheimer Disease, Agitation,Psychomotor, Care Giving Burden, NPS
IGC Pharma, LLC
Phase 2
164
Florida, Louisiana, Maryland, Missouri, New York, Oklahoma, Rhode Island, Texas
2022-10-11
Active, closed
Sterilised, Porcine Placental Tissue in the Treatment of Chronic Diabetic Foot Ulcers
NCT05687656Diabetic Foot Ulcer
ConvaTec Inc.
Not applicable
30
Florida, New York, Pennsylvania, Texas
2022-10-06
Active, closed
A Study of Bleximenib in Combination With Acute Myeloid Leukemia (AML) Directed Therapies
NCT05453903Leukemia, Myeloid, Acute
Janssen Research & Development, LLC
Phase 1
196
Alabama, California, Massachusetts, New York, North Carolina, Texas
2022-10-04
Active, closed
Study to Assess the Safety of DERMASEAL for Diabetic Foot Ulcers
NCT05586542Foot Ulcer, Diabetic
DrugPlasma
Vitruvian Medical Devices, Inc.
Phase 1
26
California, Florida, Ohio, Texas
2022-10-03
Recruiting
Outcomes Following Combined Adductoplasty™ and Lapiplasty® (MTA3D)
NCT05587569Metatarsus Adductus, Hallux Valgus
Treace Medical Concepts, Inc.
Not applicable
80
Colorado, Iowa, Maine, Missouri, North Carolina, Ohio, Pennsylvania, Texas
2022-09-28
Active, closed
A Retrospective Assessment of OviTex PRS (OviTex)
NCT05736848Reconstructive Surgical Procedures
Tela Bio Inc
Observational
200
Florida, Georgia, Massachusetts, Michigan, New Jersey, New York, South Carolina, Texas
2022-09-27
Active, closed
A Phase 1, Open-label Trial of Belzupacap Sarotalocan (AU-011) in Bladder Cancer
NCT05483868Non-muscle-invasive Bladder Cancer, NMIBC, Non-Muscle Invasive Bladder Carcinoma, Non-Muscle Invasive Bladder Neoplasms
Aura Biosciences
Phase 1
55
Arkansas, California, Colorado, New York, Pennsylvania, South Carolina, Tennessee, Texas
2022-09-26
Recruiting
Study to Investigate the Safety of the Transplantation of Human Glial Restricted Progenitor Cells Into Subjects With Transverse Myelitis
NCT03887273Transverse Myelitis
Q Therapeutics, Inc.
Phase 1/2
9
Texas
2022-09-20
Active, closed
Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors
NCT05462717Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma, Advanced Solid Tumor
Revolution Medicines, Inc.
Phase 1
222
Arkansas, California, Florida, Maryland, Massachusetts, New York, Tennessee, Texas
2022-09-19
Active, closed
XIENCE Skypoint Large Vessel Post Approval Study
NCT05423379Coronary Artery Disease
Abbott Medical Devices
Observational
102
Arkansas, Florida, Kansas, Nebraska, New York, Pennsylvania, South Carolina, Texas
2022-09-14
Recruiting
Proof of Concept Study to Eval MetriDx Lab-developed Test to Identify Endometriosis-specific Bio Markers
NCT05698212Endometriosis, Diagnosis
Hera Biotech, Inc.
Phase 2
75
Michigan, Texas
2022-09-14
Recruiting
Study of R289 in Patients With Lower-risk Myelodysplastic Syndromes (LR MDS)
NCT05308264Low Risk Myelodysplastic Syndromes
Rigel Pharmaceuticals
Phase 1/2
86
California, Florida, Missouri, New Jersey, New York, North Carolina, Ohio, Texas
2022-09-12
Recruiting
AngelMed Guardian® System PMA Post Approval Study
NCT05412927Acute Coronary Syndrome
Angel Medical Systems
Observational
500
Arizona, California, Florida, Georgia, Louisiana, Michigan, Oklahoma, Texas
2022-09-07
Active, closed
Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-101 in Participants With Myotonic Dystrophy Type 1
NCT05481879Myotonic Dystrophy Type 1 (DM1)
Dyne Therapeutics
Phase 1/2
127
California, Florida, Indiana, Iowa, Missouri, New York, Texas, Virginia
2022-09-05
Active, closed
Study of Sonrotoclax (BGB-11417) Monotherapy in Participants With Relapsed or Refractory Mantle Cell Lymphoma
NCT05471843Mantle Cell Lymphoma, Refractory Mantle Cell Lymphoma (MCL), Relapsed Mantle Cell Lymphoma
BeOne Medicines
Phase 1/2
125
Alabama, Indiana, Louisiana, Maryland, New Jersey, Texas
2022-09-05
Active, closed
A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab
NCT05378425Cancer, Tumor, Solid, Advanced Solid Tumor, Metastatic Cancer
Nectin Therapeutics Ltd
Phase 1
90
California, Louisiana, Texas
2022-09-01
Recruiting
Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT05168566Non-small Cell Lung Cancer
Teligene US
Phase 2
99
California, Georgia, Kentucky, Maryland, North Carolina, Texas
2022-09-01
Recruiting
Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer
NCT05386108Breast Neoplasms, Brain Neoplasms, Neoplasms by Site, Neoplasms
Stemline Therapeutics, Inc.
Phase 1/2
73
California, Illinois, Massachusetts, Michigan, Ohio, Oregon, Tennessee, Texas
2022-08-31
Recruiting
Asciminib Roll-over Study
NCT04877522Chronic Myelogenous Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Novartis Pharmaceuticals
Phase 4
347
Michigan, New York, Oregon, Texas, Wisconsin
2022-08-30
Recruiting
Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors
NCT05394103Advanced Cancer, Metastatic Cancer
Qurient Co., Ltd.
Phase 1/2
130
Arizona, California, Florida, Illinois, Minnesota, New Jersey, Texas
2022-08-30
Recruiting
Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears
NCT05444465Rotator Cuff Injuries
Smith & Nephew, Inc.
Not applicable
234
Georgia, Illinois, Maryland, Ohio, Pennsylvania, Texas, Wisconsin
2022-08-30
Active, closed
Affixus Natural Nail System Humeral Nail PMCF
NCT05019664Humeral Fractures, Proximal, Humeral Fractures
Zimmer Biomet
Observational
100
Texas
2022-08-29
Active, closed
Development of a Self-collection Device for Cervical Cancer Screening
NCT05669911Human Papilloma Virus Infection Type 16, Human Papilloma Virus Infection Type 18, Human Papilloma Virus
Teal Health, Inc.
Not applicable
235
California, Colorado, Louisiana, Massachusetts, Texas, Wisconsin
2022-08-28
Recruiting
Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer
NCT05455619HR+/HER2-negative Breast Cancer, Metastatic Breast Cancer
SynDevRx, Inc.
Phase 1/2
52
California, Florida, Illinois, Michigan, Ohio, Pennsylvania, Tennessee, Texas
2022-08-26
Recruiting
A Study Evaluating the Safety and Efficacy of HB0036 in Subjects With Advanced Solid Tumors
NCT05417321Advanced Solid Tumor, NSCLC
Shanghai Huaota Biopharmaceutical Co., Ltd.
Phase 1/2
80
Indiana, Texas, Washington
2022-08-25
Active, closed
A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)
NCT04752813Glioblastoma, Glioblastoma Multiforme
BPGbio
Phase 2
50
California, Massachusetts, New Jersey, New York, Texas, Virginia
2022-08-22
Active, closed
MN-001 in Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, and Hypertriglyceridemia
NCT05464784Diabetes Mellitus, Type 2, Hypertriglyceridemia, Non-Alcoholic Fatty Liver Disease
MediciNova
Phase 2
40
Nevada, Texas
2022-08-22
Recruiting
BP1001-A in Patients With Advanced or Recurrent Solid Tumors
NCT04196257Solid Tumor, Adult, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Endometrial Cancer
Bio-Path Holdings, Inc.
Phase 1
50
Maryland, Michigan, Texas
2022-08-19
Active, closed
A Study of JNJ-80948543, a T-cell Redirecting CD79b x CD20 x CD3 Trispecific Antibody, in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
NCT05424822Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell
Janssen Research & Development, LLC
Phase 1
167
California, New York, Tennessee, Texas, Washington
2022-08-18
Recruiting
A Clinical Trial of BP1002 in Patients With Refractory/Relapsed Acute Myeloid Leukemia (AML)
NCT05190471Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory
Bio-Path Holdings, Inc.
Phase 1
48
California, New York, Texas
2022-08-16
Recruiting
Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)
NCT05431270Non Small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma
Phanes Therapeutics
Phase 1/2
40
North Carolina, Oklahoma, Tennessee, Texas, Virginia
2022-08-11
Active, closed
Long-Term Follow-up Study of ADVM-022 in DME (INFINITY-EXT)
NCT05607810Diabetic Macular Edema, Diabetic Retinopathy
Adverum Biotechnologies, Inc.
Observational
22
California, Nevada, Pennsylvania, Texas
2022-08-10
Active, closed
A Study on the Long-term Efficacy, Safety and Persistence of Immune Response of a Vaccine Against Herpes Zoster in Older Adults
NCT05371080Herpes Zoster
GlaxoSmithKline
Phase 3
3,038
Arizona, Maryland, North Carolina, Pennsylvania, Tennessee, Texas, Utah
2022-08-10
Active, closed
Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01)
NCT05464030Colorectal Cancer
EMD Serono Research & Development Institute, Inc.
Phase 1
220
California, Rhode Island, Texas
2022-08-04
Recruiting
A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation
NCT05410145KRAS P.G12C
D3 Bio (Wuxi) Co., Ltd
Phase 1/2
442
California, Colorado, Florida, Michigan, Tennessee, Texas
2022-08-03
Active, closed
First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors
NCT05489237Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumor (GIST), Digestive System Disease, Gastrointestinal Diseases
IDRX, Inc., a wholly owned subsidiary of GSK, LLC
Phase 1
276
Florida, Illinois, Massachusetts, Missouri, New York, Oregon, Pennsylvania, Texas
2022-08-03
Recruiting
A Prospective Registry to Enable Collection of Standardized Routine Care Oncology Patient Data
NCT06877884Cancer
N-Power Medicine
Observational
20,000
California, Delaware, Illinois, New Mexico, Pennsylvania, Texas
2022-08-01
Recruiting
A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM
NCT05303467Glioblastoma Multiforme, Recurrent Glioblastoma
Boston Scientific Corporation
Phase 1
36
Alabama, California, Florida, Illinois, Maryland, Missouri, New York, Texas
2022-07-30
Active, closed
Neurostimulation to Improve NOWS Outcomes
NCT05129020Neonatal Opioid Withdrawal Syndrome, Neonatal Abstinence Syndrome
Spark Biomedical, Inc.
Not applicable
52
South Carolina, Texas
2022-07-27
Recruiting
Dose Regimen Study of SLI-F06 in Healthy Volunteers
NCT05501327Scar, Wound Healing
Scarless Laboratories, Inc.
Phase 2
30
California, Texas
2022-07-25
Active, closed
Autologous CD30.CAR-T in Combination With Nivolumab in cHL Patients After Failure of Frontline Therapy
NCT05352828Classical Hodgkin Lymphoma, Hodgkin Disease Refractory, Hodgkin Disease Recurrent
Tessa Therapeutics
Phase 1
15
California, Florida, North Carolina, Texas
2022-07-25
Active, closed
A Study to Determine the Efficacy and Safety of Tividenofusp Alfa (DNL310) vs Idursulfase in Pediatric and Young Adult Participants With Neuronopathic (nMPS II) or Non-Neuronopathic Mucopolysaccharidosis Type II (nnMPS II)
NCT05371613Mucopolysaccharidosis II
Denali Therapeutics Inc.
Phase 2/3
65
California, Illinois, New Jersey, North Carolina, Ohio, Pennsylvania, Texas, Utah
2022-07-21
Active, closed
SP Thoracic IDE Study
NCT05150210Primary Lung Cancer, Benign Lung Disease, Thymoma, Myasthenia Gravis
Intuitive Surgical
Not applicable
32
California, Massachusetts, New York, North Carolina, Texas
2022-07-20
Active, closed
Safety and Pharmacokinetics Study of a Modified Tafasitamab IV Dosing Regimen Combined With Lenalidomide in R-R DLBCL Patients
NCT05222555Diffuse Large B Cell Lymphoma
Incyte Corporation
Phase 1/2
53
New Jersey, Texas, Washington
2022-07-19
Active, closed
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
NCT05296798Locally Advanced or Metastatic Breast Cancer
Hoffmann-La Roche
Phase 3
922
Arizona, California, Florida, Maryland, Tennessee, Texas, Washington
2022-07-18
Active, closed
A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies
NCT05362773Leukemia, Acute Myeloid, Myelodysplastic Syndromes, Classical Hodgkin Lymphoma, Leukemia, B-cell
MacroGenics
Phase 1
130
Colorado, Maryland, Massachusetts, Michigan, Missouri, North Carolina, Texas
2022-07-13
Recruiting
A Study to Evaluate PEEL-224 in Patients With Advanced Solid Tumors
NCT05329103Advanced Solid Tumor
Peel Therapeutics Inc
Phase 1
65
Arizona, California, North Carolina, Pennsylvania, Rhode Island, Texas, Utah, Virginia
2022-07-11
Recruiting
Patient Specific Talus Spacer Post Approval Study
NCT05364606Avascular Necrosis of the Talus
Paragon 28
Observational
50
California, Indiana, Maryland, South Carolina, Texas
2022-07-08
Active, closed
Natural History of PRPF31 Mutation-Associated Retinal Dystrophy
NCT05573984Retinitis Pigmentosa, Eye Diseases, Hereditary, Retinal Dystrophies, Retinal Dystrophy Rod
PYC Therapeutics
Observational
50
California, Florida, Michigan, Oregon, Texas
2022-07-07
Recruiting
NEO100 and High-Grade Meningioma
NCT05023018Residual, Progressive or Recurrent Grade II or III Meningioma
Neonc Technologies, Inc.
Phase 2
30
California, Massachusetts, Texas
2022-07-01
By invitation
Pre-hospital Ventilation Clinical Study
NCT05604430Altered Mental Status, Sepsis, Heart Failure, Hemorrhage
Zoll Medical Corporation
Observational
500
Connecticut, Louisiana, Massachusetts, Texas, Washington
2022-06-30
Active, closed
A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium
NCT05456425Pterygium
Cloudbreak Therapeutics, LLC
Phase 3
660
Alabama, Arizona, California, Florida, Kentucky, Nevada, South Dakota, Texas
2022-06-30
Active, closed
Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutations
NCT05364073Non-Small Cell Lung Cancer (NSCLC), Metastatic Non-Small Cell Lung Cancer, Advanced Non-Small Cell Lung Cancer, HER2 Exon 20 Mutations
ArriVent BioPharma, Inc.
Phase 1
160
Arizona, California, Florida, Michigan, Texas, Virginia
2022-06-30
Recruiting
Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% and LUMIGAN® in the Treatment of Chronic Open-Angle Glaucoma or Ocular Hypertension in Both Eyes.
NCT05401357Glaucoma, Open-Angle, Ocular Hypertension
Amneal Pharmaceuticals, LLC
Phase 3
168
California, Florida, Georgia, Tennessee, Texas, Wyoming
2022-06-29
Active, closed
A Trial to Assess the Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With PLD
NCT05281328Polycystic Liver Disease
Camurus AB
Phase 2/3
71
Minnesota, New York, Pennsylvania, Texas, Virginia
2022-06-28
Recruiting
Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies
NCT05417594Advanced Solid Malignancies
AstraZeneca
Phase 1/2
695
California, Illinois, Massachusetts, New York, Oregon, Texas, Virginia
2022-06-24
Recruiting
Comprehensive Outcomes for After Cancer Health
NCT05349227Ovarian Cancer, Breast Cancer, Lung Cancer, Gastric Cancer
Pack Health
Not applicable
625
Florida, Massachusetts, Nebraska, New York, Ohio, Texas
2022-06-23
Active, closed
Safety, Tolerability and Efficacy of QRX003 Lotion in Subjects With Netherton Syndrome
NCT05521438Netherton Syndrome
Quoin Pharmaceuticals
Phase 2/3
30
California, Indiana, Massachusetts, South Carolina, Texas
2022-06-23
Recruiting
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
NCT05142189Non-Small Cell Lung Cancer
BioNTech SE
Phase 1
320
Kentucky, Maryland, Ohio, Texas, Virginia
2022-06-17
Recruiting
Real World Insights During Treatment for Relapsed/Refractory Multiple Myeloma with Isatuximab
NCT05053607Multiple Myeloma, Refractory Multiple Myeloma
Pack Health
Not applicable
50
Texas, Washington
2022-06-17
Active, closed
A Study of MK-1484 as Monotherapy and in Combination With Pembrolizumab (MK-3475) In Advanced or Metastatic Solid Tumors (MK-1484-001)
NCT05382325Advanced or Metastatic Solid Tumors
Merck Sharp & Dohme LLC
Phase 1
70
South Dakota, Texas
2022-06-16
Recruiting
ADG126 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors
NCT05405595Advanced/Metastatic Solid Tumors
Adagene Inc
Phase 1/2
186
Arizona, California, Florida, Ohio, Texas, Washington
2022-06-15
Active, closed
ProVee Urethral Expander System IDE Study (ProVIDE)
NCT05186740BPH With Symptomatic Lower Urinary Tract Symptoms
ProVerum Medical
Not applicable
221
California, Florida, Illinois, Nevada, New York, North Carolina, Texas, Virginia
2022-06-09
Recruiting
Study of TL-895 Combined With Ruxolitinib in JAKi Treatment-Naïve MF Subjects and Subjects With MF Who Have a Suboptimal Response to Ruxolitinib
NCT05280509Myelofibrosis, Primary Myelofibrosis, Post-PV MF, Post-ET Myelofibrosis
Telios Pharma, Inc.
Phase 1/2
70
Alabama, Ohio, Texas
2022-06-09
Active, closed
Longitudinal Bladder Cancer Study for Tumour Recurrence
NCT05080998Urothelial Bladder Cancer
Pacific Edge Limited
Observational
450
Florida, South Carolina, Texas, Vermont, Washington
2022-06-08
Active, closed
A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period
NCT05144256Pediatric Pyruvate Kinase Deficiency, Pediatric Hemolytic Anemia
Agios Pharmaceuticals, Inc.
Phase 3
49
Arizona, California, Georgia, Massachusetts, Nevada, New York, Pennsylvania, Texas
2022-06-08
Recruiting
A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer
NCT05365581Gastric Adenocarcinoma, Gastroesophageal Junction (GEJ) Adenocarcinoma, Pancreatic Adenocarcinoma
Astellas Pharma Global Development, Inc.
Phase 1
398
California, Illinois, Kansas, New Jersey, New York, North Carolina, Texas, Washington
2022-06-07
Active, closed
A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies
NCT05428969Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes, Relapsed/Refractory AML
Faron Pharmaceuticals Ltd
Phase 1/2
181
California, Connecticut, North Carolina, Texas
2022-06-02
Active, closed
Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer
NCT05367440Metastatic Prostate Cancer
AstraZeneca
Phase 1/2
174
Michigan, New York, South Carolina, Texas
2022-06-02
Recruiting
AB8939 in Patients With Relapsed/Refractory Acute Myeloid Leukemia
NCT05211570Acute Myeloid Leukemia Refractory, Acute Myeloid Leukemia, in Relapse, Myelodysplastic Syndrome Acute Myeloid Leukemia
AB Science
Phase 1/2
78
Texas
2022-06-01
Active, closed
A Study of mRNA-3745 in Adult and Pediatric Participants With Glycogen Storage Disease Type 1a (GSD1a)
NCT05095727Glycogen Storage Disease
ModernaTX, Inc.
Phase 1/2
15
Connecticut, Massachusetts, North Carolina, Ohio, Pennsylvania, Texas, Utah
2022-06-01
Recruiting
S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Advanced or Metastatic Solid Tumors
NCT05101070Solid Tumors
Shionogi
Phase 1/2
282
California, Florida, Michigan, Pennsylvania, Texas
2022-05-30
Recruiting
A TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFICACY OF SHR-A1904 IN SUBJECTS WITH ADVANCED SOLID TUMORS
NCT05277168Advanced Solid Tumors
Jiangsu HengRui Medicine Co., Ltd.
Phase 1/2
83
Florida, Louisiana, Ohio, Rhode Island, South Carolina, Texas
2022-05-30
Active, closed
CFI-402257, a Potent and Selective TTK Inhibitor, in Solid Tumors and With Fulvestrant in Breast Cancer
NCT05251714Advanced Solid Tumor, Breast Cancer
Treadwell Therapeutics, Inc
Phase 1/2
44
Ohio, Texas, Utah, Virginia
2022-05-27
Recruiting
Acute Partial Thickness Burn Study Comparing Transforming Powder Dressing to Standard of Care Dressing
NCT05424354Wounds and Injuries
ULURU Inc.
Phase 4
60
California, District of Columbia, Florida, Kentucky, New York, Texas
2022-05-26
Recruiting
A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia
NCT05304377Chronic Myeloid Leukemia, Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Cml
Enliven Therapeutics
Phase 1
250
New York, Oregon, Texas
2022-05-22
Active, closed
A.L.P.S. Clavicle Plating System PMCF
NCT05327959Clavicle Fracture, Clavicle Injury
Zimmer Biomet
Not applicable
98
Florida, Michigan, Oregon, Texas
2022-05-13
Active, closed
A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.
NCT05109728Glioblastoma
Novartis Pharmaceuticals
Phase 1
63
New York, Pennsylvania, Texas, Wisconsin
2022-05-10
By invitation
Posterior Cervical Fixation Study
NCT04770571Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease
NuVasive
Observational
150
California, Connecticut, Maryland, New York, Pennsylvania, Tennessee, Texas
2022-05-10
Active, closed
RAdiolabeled Perfusion to Identify Coronary Artery Disease Using WAter To Evaluate Responses of Myocardial FLOW (RAPID-WATER-FLOW)
NCT05134012Coronary Artery Disease
MedTrace Pharma A/S
Phase 3
215
Iowa, Minnesota, Missouri, Pennsylvania, Texas, Virginia
2022-05-08
Recruiting
Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.
NCT04771572Non Hodgkin Lymphoma, Richter Transformation, Multiple Myeloma, T-cell-prolymphocytic Leukemia
Newave Pharmaceutical Inc
Phase 1
100
Illinois, Massachusetts, North Carolina, Ohio, Texas, Utah
2022-05-08
Active, closed
A Study to Evaluate the Effect of Venglustat Tablets on Left Ventricular Mass Index in Male and Female Adult Participants With Fabry Disease
NCT05280548Fabry Disease
Sanofi
Phase 3
104
Alabama, California, Georgia, Illinois, New York, Texas, Utah, Virginia
2022-05-03
Recruiting
Daily Adaptive Radiation Therapy an Individualized Approach for Carcinoma of the Cervix
NCT05197881Cervical Cancer by FIGO Stage 2018
Varian, a Siemens Healthineers Company
Not applicable
125
Alabama, Arkansas, California, Pennsylvania, Texas
2022-05-03
Active, closed
Study to Evaluate the Efficacy and Safety of Venglustat in Adult and Pediatric Patients With Gaucher Disease Type 3
NCT05222906Gaucher's Disease Type III
Sanofi
Phase 3
43
Connecticut, Iowa, Texas, Virginia
2022-04-18
Recruiting
Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System
NCT05406167Cancer, Cancer Central Nervous System, Cancer Thoracic, Cancer, Gastrointestinal
RefleXion Medical
Observational
500
California, Connecticut, Pennsylvania, Texas
2022-04-12
Active, closed
Butterfly Pivotal Study
NCT05341661BPH (Benign Prostatic Hyperplasia), Lower Urinary Tract Symptoms (LUTS)
Butterfly Medical Ltd.
Not applicable
245
New York, Texas
2022-04-07
Active, closed
Study of ADI-PEG 20, Venetoclax and Azacitidine in Acute Myeloid Leukemia
NCT05001828Acute Myeloid Leukemia, Adult
Polaris Group
Phase 1
38
Florida, North Carolina, Texas
2022-04-05
Recruiting
Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
NCT05267626Advanced Solid Tumor, Metastatic Cancer, Cutaneous Melanoma, Non-Small Cell Lung Cancer
Aulos Bioscience, Inc.
Phase 1/2
159
Florida, Michigan, Minnesota, Missouri, North Carolina, Tennessee, Texas, Utah
2022-04-04
Active, closed
Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
NCT05215574Pancreatic Cancer, Breast Cancer, Gastric Cancer, Non-small Cell Lung Cancer
NGM Biopharmaceuticals, Inc
Phase 1
130
Arizona, California, Florida, Michigan, New York, Oklahoma, Texas
2022-03-31
Active, closed
A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors
NCT05159700Advanced Solid Tumor, Advanced Solid Malignancies
Zhuhai Yufan Biotechnologies Co., Ltd
Phase 1
39
Colorado, Florida, Ohio, Texas, Virginia
2022-03-31
Recruiting
A Study in Patients With Advanced Cancers
NCT05320588Advanced Cancer, Advanced Solid Tumor, Cancer, Oncology
BiOneCure Therapeutics Inc.
Phase 1/2
332
Texas, Virginia
2022-03-25
Active, closed
First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors
NCT05277051Neoplasms
GlaxoSmithKline
Phase 1
152
California, North Carolina, Oklahoma, Pennsylvania, Texas, Utah
2022-03-22
Active, closed
Non-Guided vs. Guided Surgery to Immediately Loaded PrimeTaper Implants in Partially Edentulous Patients
NCT05264545Partially Edentulous Maxilla or Mandible
McGuire Institute
Not applicable
100
Colorado, Illinois, Nebraska, Tennessee, Texas, Washington, Wisconsin
2022-03-22
Active, closed
A Study to Learn About the Study Medicine (Called PF-07220060 in Combination With PF-07104091) In Participants With Breast Cancer and Solid Tumors
NCT05262400Breast Cancer, Solid Tumors
Pfizer
Phase 1/2
235
California, Massachusetts, Michigan, Missouri, Texas, Washington
2022-03-14
Recruiting
GPC3-Targeted T-Cell Therapy (ECT204) in Adults With Advanced HCC
NCT04864054Hepatocellular Carcinoma, Liver Cancer, Adult, Liver Neoplasm, Metastatic Liver Cancer
Eureka Therapeutics Inc.
Phase 1/2
60
California, Kansas, New York, Oregon, Texas, Washington
2022-03-11
Recruiting
Allogenic Hepatocyte Transplantation Into Periduodenal Lymph Nodes
NCT04496479End Stage Liver Disease
LyGenesis, Inc.
Phase 2
12
Massachusetts, Texas
2022-03-11
Active, closed
A Study to Evaluate the Effect of Venglustat Tablets on Neuropathic and Abdominal Pain in Male and Female Participants ≥16 Years of Age With Fabry Disease
NCT05206773Fabry Disease
Sanofi
Phase 3
122
Alabama, California, Florida, Georgia, New York, Ohio, Pennsylvania, Texas
2022-03-11
Active, closed
A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
NCT05238883Gastric Cancer, Renal Cell Carcinoma, Melanoma, Sarcoma
HiFiBiO Therapeutics
Phase 1
72
Arizona, California, Florida, Minnesota, Missouri, Texas, Virginia
2022-03-10
Recruiting
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia
NCT05091424Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Hoffmann-La Roche
Phase 1
332
Minnesota, New York, Ohio, Texas, Utah
2022-03-07
Active, closed
Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving Terminated Nerve Ends
NCT04865679Symptomatic Neuroma, Amputation, Chronic Nerve Pain
Axogen Corporation
Not applicable
15
Massachusetts, Texas
2022-03-02
Recruiting
Inappropriate Sinus Tachycardia Registry
NCT05107635Inappropriate Sinus Tachycardia, Postural Tachycardia Syndrome
AtriCure, Inc.
Observational
500
California, Florida, Kansas, Maryland, Ohio, Texas, Utah, Washington
2022-03-01
Recruiting
Multi-analyte Blood Test Clinical Trial
NCT05199259Liver Cirrhosis, Liver Cancer, HCC, Hepatocellular Carcinoma
Helio Genomics
Observational
1,200
California, Florida, Texas
2022-03-01
Recruiting
MTX-001 for the Treatment of Non-Healing Venous Stasis Ulcers
NCT04647240Venous Stasis Ulcer, Venous Leg Ulcer
Merakris Therapeutics
Phase 2
80
Arizona, California, Florida, Louisiana, New York, Ohio, Texas, Virginia
2022-02-26
Active, closed
A Study to Evaluate the Safety and Pharmacokinetics of Single and Multiple Doses of Prosetin in Healthy Volunteers and Participants With ALS
NCT05279755Amyotrophic Lateral Sclerosis
ProJenX
Phase 1
72
Massachusetts, Texas
2022-02-26
Active, closed
Clinical Study Of a Micro-Implantable Pulse Generator For The Treatment of Peripheral Neuropathic Pain
NCT05287373Peripheral Neuralgia, Chronic Pain
Nalu Medical, Inc.
Not applicable
89
Arizona, Arkansas, California, Colorado, District of Columbia, North Carolina, Oregon, Texas
2022-02-23
Recruiting
Posaconazole (MK-5592) Intravenous and Oral in Children (<2 Years) With Invasive Fungal Infection (MK-5592-127)
NCT04665037Invasive Fungal Infection
Merck Sharp & Dohme LLC
Phase 2
40
California, Florida, Illinois, North Carolina, Texas
2022-02-22
Active, closed
Long-term Follow-up Study of Allogeneic Gamma Delta (γδ) CAR T Cells
NCT04911478Lymphoma, Follicular, Lymphoma, Mantle-Cell, Marginal Zone Lymphoma, Primary Mediastinal B-cell Lymphoma
Adicet Therapeutics
Observational
50
California, Kentucky, Texas, Wisconsin
2022-02-14
Active, closed
Optilume PoST AppRoval Clinical Evaluation of Andrology ParaMeters
NCT05383274Urethral Stricture
Urotronic Inc.
Phase 4
34
Arkansas, Florida, Louisiana, Maryland, Nevada, New Jersey, New York, Texas
2022-02-14
Recruiting
Study to Evaluate IMP9064 as a Monotherapy or in Combination in Patients With Advanced Solid Tumors
NCT05269316Solid Tumor, Advanced Solid Tumor
Impact Therapeutics, Inc.
Phase 1/2
61
New Jersey, New York, South Carolina, Texas
2022-02-11
Active, closed
Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc
NCT05258435Cervical Disc Disease, Degenerative Disc Disease
NuVasive
Observational
131
California, Colorado, Florida, Illinois, Indiana, Louisiana, North Carolina, Texas
2022-02-09
Recruiting
US Post-Market Surveillance Study of the Surfacer System
NCT05050799Venous Disease
Merit Medical Systems, Inc.
Observational
30
Arizona, Florida, Georgia, Ohio, Texas, Utah, Virginia
2022-02-08
Recruiting
Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma
NCT04879043Multiple Myeloma, Plasma Cell Disorder
Heidelberg Pharma AG
Phase 1/2
78
Georgia, Kentucky, Nebraska, New York, Texas
2022-02-07
Active, closed
First in Human Study of TORL-2-307-ADC in Participants With Advanced Cancer
NCT05156866Advanced Solid Tumor, Gastric Cancer, Pancreas Cancer, Gastroesophageal Junction Adenocarcinoma
TORL Biotherapeutics, LLC
Phase 1
163
California, Indiana, Missouri, Texas
2022-02-02
Active, closed
Study to Assess the Safety and Efficacy of OCU400 for Retinitis Pigmentosa and Leber Congenital Amaurosis
NCT05203939Retinitis Pigmentosa, Leber Congenital Amaurosis
Ocugen
Phase 1/2
22
Arizona, California, Florida, Georgia, Oregon, Pennsylvania, Texas
2022-01-24
Active, closed
Progressive Myopia Treatment Evaluation for NaturalVue Multifocal Contact Lens Trial
NCT05159765Myopia
Visioneering Technologies, Inc
Not applicable
144
California, Illinois, New York, Texas
2022-01-22
Active, closed
Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN
NCT05309668Neurofibromatosis Type 1
AstraZeneca
Phase 1/2
36
Ohio, Pennsylvania, Texas, Virginia
2022-01-21
Recruiting
Pelvic Health Electrically Evoked Recording (PEER) 2 Study
NCT05200923Overactive Bladder, Fecal Incontinence, Urinary Retention
MedtronicNeuro
Not applicable
300
Indiana, Louisiana, Minnesota, Ohio, Texas
2022-01-18
Recruiting
Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics
NCT05490888Cirrhosis, Liver, Liver Fibrosis, Ascites Hepatic
PharmaIN
Phase 1
74
Arizona, California, Louisiana, Minnesota, Ohio, Pennsylvania, Texas
2022-01-03
By invitation
A Longitudinal, Multi-Center Safety Study of Autologous Adult Adipose-Derived Regenerative Cell Injection Into Chronic Partial-Thickness Rotator Cuff Tears
NCT05400798Partial Thickness Rotator Cuff Tear
InGeneron, Inc.
Not applicable
246
Arizona, California, Florida, Georgia, Louisiana, South Dakota, Texas
2022-01-01
Active, closed
A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies
NCT05199272Solid Tumor, Clear Cell Renal Cell Carcinoma, Epithelial Ovarian Cancer, Fallopian Tube Cancer
23andMe, Inc.
Phase 1/2
141
California, Georgia, Michigan, New York, Oregon, Tennessee, Texas, Virginia
2021-12-29
Recruiting
Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia
NCT04925479Myeloid Leukemia, Philadelphia Positive
DrugABL001
Novartis Pharmaceuticals
Phase 1/2
34
Indiana, Massachusetts, Mississippi, New York, Ohio, Pennsylvania, Texas, Utah
2021-12-27
Active, closed
HALOS: A Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Multiple Ascending Doses of ION582 in Participants With Angelman Syndrome
NCT05127226Angelman Syndrome
Ionis Pharmaceuticals, Inc.
Phase 1/2
71
California, Colorado, Illinois, Massachusetts, North Carolina, Texas
2021-12-22
Active, closed
Targeted Alpha-emitter Therapy of PRRT Naïve and Previous PRRT Neuroendocrine Tumor Patients
NCT05153772Neuroendocrine Tumors
Orano Med LLC
Phase 2
69
Colorado, Florida, Louisiana, Texas
2021-12-21
Active, closed
A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)
NCT04819100Carcinoma, Non-Small-Cell Lung
Eli Lilly and Company
Phase 3
152
California, Florida, Massachusetts, Minnesota, New York, Pennsylvania, Tennessee, Texas
2021-12-20
Active, closed
Targeted Alpha Therapy With 225Actinium-Prostate Specific Membrane Antigen (PSMA)-I&T of Castration-resISTant Prostate Cancer (TATCIST).
NCT05219500Metastatic Castration Resistant Prostate Cancer
Fusion Pharmaceuticals Inc.
Phase 2
115
Nebraska, Texas
2021-12-16
Recruiting
Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Renal Impairment
NCT04953897Acute Myeloid Leukemia, Myelodysplastic Syndromes
Taiho Oncology, Inc.
Phase 1
18
Texas
2021-12-15
Active, closed
BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)
NCT04982393Primary Hyperoxaluria Type 1
Alnylam Pharmaceuticals
Observational
207
Arizona, District of Columbia, Massachusetts, Minnesota, Ohio, Pennsylvania, Texas
2021-12-13
Active, closed
A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations
NCT05163028Non Small Cell Lung Cancer, Colorectal Cancer, Pancreatic Cancer, Solid Tumor
HUYABIO International, LLC.
Phase 1
42
California, Florida, Ohio, Texas, Virginia
2021-12-13
Active, closed
Safety, Pharmacokinetics and Clinical Activity of AZD0171 in Combination With Durvalumab and Chemotherapy in Locally Advanced or Metastatic Solid Tumours
NCT04999969Locally Advanced or Metastatic Solid Tumours
AstraZeneca
Phase 2
126
California, Georgia, Idaho, Massachusetts, Michigan, New York, Oregon, Texas
2021-12-10
Active, closed
Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases
NCT05034497Leptomeningeal Metastasis
Cerenome
Phase 1
18
Illinois, New York, Ohio, Texas
2021-12-06
Recruiting
Phase 1/2 Study of TU2218 Alone and in Combination With Checkpoint Inhibitors in Patients With Advanced Solid Tumors
NCT05204862Advanced Solid Tumor
DrugTU2218
TiumBio Co., Ltd.
Phase 1/2
240
Texas
2021-12-02
Active, closed
Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma
NCT04910022Glioblastoma, Diffuse Glioma
Nerviano Medical Sciences
Phase 1/2
150
Arizona, California, Florida, Massachusetts, Minnesota, New York, Texas, Utah
2021-12-01
Recruiting
Pediatric Post-Approval Registry
NCT04457154Obstructive Sleep Apnea
Inspire Medical Systems, Inc.
Observational
60
Colorado, Georgia, North Carolina, Ohio, Pennsylvania, Texas, Virginia
2021-11-30
Recruiting
First in Human Study of TORL-1-23 in Participants With Advanced Cancer
NCT05103683Advanced Solid Tumor, Ovarian Cancer, Endometrial Cancer, NSCLC
TORL Biotherapeutics, LLC
Phase 1
90
California, Kentucky, Minnesota, New York, Ohio, Texas, Virginia
2021-11-17
Active, closed
Investigation of Remimazolam in Children Undergoing Sedation for Medical Procedures
NCT04851717Pediatric ALL
Acacia Pharma Ltd
Phase 2/3
100
California, Massachusetts, Minnesota, Pennsylvania, Texas
2021-11-15
Recruiting
A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study
NCT05130437Propionic Acidemia
ModernaTX, Inc.
Phase 1/2
50
California, Michigan, New York, North Carolina, Pennsylvania, Texas
2021-11-09
Active, closed
Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia
NCT04994717Newly Diagnosed Philadelphia (Ph)-Negative B-cell Precursor Acute Lymphoblastic Leukemia (ALL)
Amgen
Phase 3
303
California, Florida, Ohio, South Carolina, Texas
2021-11-02
Active, closed
A Study of the Safety and Tolerability in Participants With PIK3CA-related Overgrowth Spectrum or Proteus Syndrome Who Are Being Treated With Miransertib (MK-7075) in Other Studies (MK-7075-006)
NCT04980872PIK3CA-Related Overgrowth Spectrum (PROS)/Proteus Syndrome (PS)
Merck Sharp & Dohme LLC
Phase 2
60
Georgia, Massachusetts, Ohio, Texas, Washington
2021-11-02
Active, closed
Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression
NCT05163041Advanced Solid Tumor
BicycleTx Limited
Phase 1/2
200
Iowa, New York, Ohio, Pennsylvania, Texas, Virginia
2021-11-02
Active, closed
Cinrebafusp Alfa in Combination With Ramucirumab and Paclitaxel in HER2-High Gastric or GEJ Adenocarcinoma and in Combination With Tucatinib in HER2-Low Gastric or GEJ Andenocarinoma
NCT05190445HER2-positive Gastric Cancer
Pieris Pharmaceuticals, Inc.
Phase 2
80
California, Maryland, New York, Texas
2021-11-01
Active, closed
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS)
NCT04861259Atypical Hemolytic Uremic Syndrome
Hoffmann-La Roche
Phase 3
83
California, Colorado, Georgia, Missouri, Ohio, Texas
2021-10-22
Active, closed
A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors
NCT04857372Mesothelioma
Novartis Pharmaceuticals
Phase 1
137
California, Illinois, Massachusetts, Ohio, Texas
2021-10-21
Active, closed
Post Market Clinical Follow-Up Study in Patients Treated With the On-X Ascending Aortic Prosthesis (AAP)
NCT05082454Aortic Valve Disease
JOTEC GmbH
Observational
108
Pennsylvania, Texas, Virginia
2021-10-20
Recruiting
ConsideRAte Study - Splenic Stimulation for RA
NCT05003310Rheumatoid Arthritis
Galvani Bioelectronics
Not applicable
28
Alabama, California, Maryland, New York, Oregon, Pennsylvania, Texas
2021-10-19
Active, closed
OCS Liver Perfusion (OLP) Post-Approval Registry
NCT05074160Liver Transplant
TransMedics
Observational
166
Alabama, California, Georgia, Massachusetts, Michigan, Nebraska, North Carolina, Texas
2021-10-14
By invitation
SPI-1005 Treatment in Moderate COVID-19 Patients
NCT04484025Covid19, Corona Virus Infection, Coronavirus, Coronavirus Infection
Sound Pharmaceuticals, Incorporated
Phase 2
60
Connecticut, Idaho, Kansas, Missouri, North Carolina, Texas
2021-10-12
Active, closed
A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
NCT04931342Ovarian Cancer
Hoffmann-La Roche
Phase 2
176
California, Missouri, North Carolina, Ohio, Oklahoma, Texas, Virginia, Washington
2021-10-07
Active, closed
Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing
NCT05059522Advanced Malignancies, NSCLC, Ovarian Cancer, Urothelial Cancer
Pfizer
Phase 3
77
Arkansas, California, Florida, New Jersey, New York, Pennsylvania, Texas, Washington
2021-09-29
Recruiting
A Study of NX-1607 in Adults With Advanced Malignancies
NCT05107674Ovarian Cancer, Epithelial, Gastric Cancer, GastroEsophageal Junction (GEJ) Cancer, Head and Neck Squamous Cell Carcinoma
Nurix Therapeutics, Inc.
Phase 1
345
California, Colorado, Illinois, North Carolina, Oklahoma, Texas, Virginia, Washington
2021-09-29
Recruiting
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
NCT04703842Congestive Heart Failure, Heart Failure, Systolic, Heart Failure, HFrEF - Heart Failure With Reduced Ejection Fraction
Sardocor Corp.
Phase 1/2
57
California, Missouri, Texas, Washington
2021-09-23
Active, closed
A Study to Evaluate Safety and Efficacy of ACT001 and Anti-PD-1 in Patients With Surgically Accessible Recurrent Glioblastoma Multiforme
NCT05053880Recurrent Glioblastoma Multiforme(GBM)
Accendatech USA Inc.
Phase 1/2
48
Texas
2021-09-22
Active, closed
A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes
NCT04747431Frontotemporal Dementia, FTD, FTD-GRN, Dementia Frontotemporal
Passage Bio, Inc.
Phase 1/2
30
Michigan, Pennsylvania, Tennessee, Texas
2021-09-14
Active, closed
Study of Selinexor Plus DRd for Newly Diagnosed Multiple Myeloma
NCT04782687Multiple Myeloma, Myeloma Multiple, Kahler Disease, Myeloma, Plasma Cell
US Oncology Research
Phase 2
73
Arizona, Colorado, Maryland, New York, Oregon, Texas, Virginia
2021-09-10
Active, closed
A Study to Test Different Doses of BI 1823911 Alone and Combined With Other Medicines in People With Different Types of Advanced Cancer With KRAS Mutation
NCT04973163Solid Tumors, KRAS Mutation
Boehringer Ingelheim
Phase 1
30
New York, Texas
2021-09-09
Active, closed
Phase 1 Study of Autologous CD30.CAR-T in Relapsed or Refractory CD30 Positive Non-Hodgkin Lymphoma
NCT04526834Anaplastic Large Cell Lymphoma, Peripheral T Cell Lymphoma, Extranodal NK/T-cell Lymphoma, Diffuse Large B Cell Lymphoma
Tessa Therapeutics
Phase 1
21
California, Tennessee, Texas
2021-09-08
Recruiting
Quaratusugene Ozeplasmid (Reqorsa) and Osimertinib in Patients With Advanced Lung Cancer Who Progressed on Osimertinib
NCT04486833Carcinoma, Non-Small Cell Lung
Genprex, Inc.
Phase 1/2
158
California, Colorado, Illinois, Kentucky, Maryland, New Jersey, Ohio, Texas
2021-09-03
Active, closed
A Phase I/II Study of VTX-801 in Adult Patients With Wilson's Disease
NCT04537377Wilson's Disease
Vivet Therapeutics SAS
Phase 1/2
4
California, Connecticut, Florida, Michigan, North Carolina, Texas
2021-09-03
Recruiting
Freedom-1 Study for Chronic Knee Pain
NCT03877653Osteoarthritic Knee Pain
Curonix LLC
Not applicable
100
California, Colorado, Florida, Georgia, Nevada, Ohio, Texas
2021-09-01
Active, closed
Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC
NCT04919811Non Small Cell Lung Cancer
Nuvation Bio Inc.
Phase 2
217
California, Florida, Louisiana, Minnesota, New Jersey, Ohio, Tennessee, Texas
2021-09-01
Recruiting
Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder
NCT05025605Schizophrenia, Schizo-Affective Disorder, Schizophreniform; Schizophrenic, Bipolar Disorder I
BioXcel Therapeutics Inc
Phase 1
140
California, Florida, Georgia, Texas
2021-08-27
Recruiting
A Beta-only IL-2 ImmunoTherapY Study
NCT05086692Advanced Solid Tumor, Unresectable Solid Tumor, Clear Cell Renal Cell Carcinoma, Triple Negative Breast Cancer
Medicenna Therapeutics, Inc.
Phase 1/2
115
California, Florida, Georgia, Michigan, Texas
2021-08-27
Active, closed
STOP Persistent AF PAS
NCT05005949Persistent Atrial Fibrillation
Medtronic Cardiac Ablation Solutions
Observational
400
Connecticut, Florida, Illinois, Michigan, Ohio, Texas
2021-08-19
Active, closed
Study of Denikitug (GS-1811) Given Alone or With Zimberelimab in Adults With Advanced Solid Tumors
NCT05007782Advanced Solid Tumor
Gilead Sciences
Phase 1
304
California, Connecticut, Massachusetts, Tennessee, Texas, Wisconsin
2021-08-18
Recruiting
Reducing Pregnancy Risks: The Mastery Lifestyle Intervention
NCT05012072Mental Health Wellness 1, Preterm Birth
Microgen LLC
Not applicable
238
Texas
2021-08-01
Active, closed
MIRACLE of LIFE Study
NCT06074601Preterm Labor, Preterm Birth, Preterm Birth Complication, Preterm Premature Rupture of Membrane
Mirvie
Observational
10,000
California, Florida, Louisiana, Massachusetts, Missouri, Ohio, Pennsylvania, Texas
2021-08-01
Active, closed
A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD
NCT04691154Pulmonary Arterial Hypertension, Pulmonary Hypertension Due to Lung Diseases
Liquidia Technologies, Inc.
Phase 3
28
Arizona, California, Florida, New York, Ohio, Oregon, Texas
2021-08-01
Active, closed
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
NCT04969835Salivary Gland Tumor, Urothelial Carcinoma, Ovarian Carcinoma, Breast Cancer
Avacta Life Sciences Ltd
Phase 1
158
New York, Texas, Washington
2021-07-16
Recruiting
A Study Evaluating APG-115 as a Single Agent or in Combination With APG-2575 in Subjects With R/R T-PLL and NHL
NCT04496349T-Prolymphocytic Leukemia, Non-Hodgkins Lymphoma
Ascentage Pharma Group Inc.
Phase 2
78
Texas
2021-07-12
Active, closed
Triathlon All-Polyethylene Tibia Outcomes Study
NCT04636190Arthropathy of Knee, Replacement, Knee Arthritis
Stryker Orthopaedics
Not applicable
204
Michigan, New York, North Carolina, Ohio, Texas
2021-07-02
Recruiting
A Study to Evaluate the Safety and Efficacy of EscharEx (EX-02) in the Treatment of Basal Cell Carcinoma
NCT05157763Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma
MediWound Ltd
Phase 1/2
32
Florida, Texas
2021-06-30
Active, closed
A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy
NCT04629248Primary Membranous Nephropathy
Hoffmann-La Roche
Phase 3
142
California, Colorado, Florida, Iowa, Michigan, Minnesota, New York, Texas
2021-06-25
Recruiting
A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis
NCT04372108Crohn Disease, Colitis, Ulcerative
Janssen Scientific Affairs, LLC
Observational
1,536
Texas
2021-06-24
Active, closed
Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea
NCT04801771Down Syndrome, Obstructive Sleep Apnea
Inspire Medical Systems, Inc.
Not applicable
57
Georgia, Massachusetts, Ohio, Pennsylvania, Texas, Virginia, Wisconsin
2021-06-24
Active, closed
FHD-286 as Monotherapy or Combination Therapy in Subjects With Advanced Hematologic Malignancies
NCT04891757Advanced Hematologic Malignancy, Relapsed Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia, Relapsed Myelodysplastic Syndromes
Foghorn Therapeutics Inc.
Phase 1
144
California, Massachusetts, New York, Tennessee, Texas
2021-06-14
Recruiting
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study
NCT04657822Sickle Cell Disease
Novartis Pharmaceuticals
Phase 4
130
Alabama, District of Columbia, Georgia, North Carolina, Pennsylvania, Texas
2021-06-10
Active, closed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral GB2064 in Participants With Myelofibrosis
NCT04679870Myelofibrosis
Galecto Biotech AB
Phase 2
21
Texas
2021-06-09
Recruiting
A Study of BTX-A51 in People With Advanced Solid Tumor and Breast Cancer
NCT04872166Advanced Solid Tumor, Metastatic Breast Cancer
Edgewood Oncology Inc.
Phase 1
112
Florida, Ohio, Tennessee, Texas
2021-06-07
Active, closed
da Vinci SP® Investigational Device Exemption Study in Colorectal Procedures
NCT04403022Colorectal Cancer, Benign or Malignant Rectal or Colon Tumors
Intuitive Surgical
Not applicable
60
Florida, Michigan, Minnesota, Nevada, Pennsylvania, Texas, Washington
2021-06-03
Active, closed
A Study of IV HBI-3000 for the Conversion Recent Onset Atrial Fibrillation (AF)
NCT04680026Atrial Fibrillation
HUYABIO International, LLC.
Phase 2
150
Florida, Illinois, Mississippi, Texas
2021-06-01
Recruiting
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
NCT04895709Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer
Bristol-Myers Squibb
Phase 1/2
1,109
California, Iowa, New Jersey, New York, Oregon, Tennessee, Texas
2021-05-27
Recruiting
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
NCT04844606Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
Eli Lilly and Company
Phase 3
150
California, Connecticut, Georgia, Massachusetts, Missouri, New York, Pennsylvania, Texas
2021-05-26
Recruiting
A Study of BGB-11417 in Participants With Myeloid Malignancies
NCT04771130Acute Myeloid Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasm
BeOne Medicines
Phase 1/2
260
California, Florida, Pennsylvania, Texas, Wisconsin
2021-05-24
Active, closed
A Study of MRG002 in Patients with HER2-Positive Advanced Solid Tumors and Locally Advanced or Metastatic Gastric/Gastroesophageal Junction (GEJ) Cancer
NCT04492488Advanced Solid Tumors, Advanced or Metastatic Gastric Cancer, Advanced or Metastatic Gastroesophageal Junction Cancer
DrugMRG002
Shanghai Miracogen Inc.
Phase 1/2
129
California, Texas
2021-05-24
Recruiting
A Study to Evaluate the Safety and Pharmacokinetics of Eflapegrastim in Pediatric Participants With Solid Tumors or Lymphomas and Treated With Myelosuppressive Chemotherapy
NCT04570423Solid Tumors, Lymphoma
Spectrum Pharmaceuticals, Inc
Phase 2
40
New York, North Carolina, Ohio, Texas
2021-05-20
Recruiting
GORE® ENFORM Biomaterial Product Study
NCT04718168Hernia, Ventral, Hernia, Hiatal, Hernia, Diaphragmatic, Incisional Hernia
W.L.Gore & Associates
Not applicable
245
California, Colorado, Florida, Illinois, Kentucky, North Carolina, South Carolina, Texas
2021-05-17
Active, closed
A Study of SmartFlow Magnetic Resonance (MR) Compatible Ventricular Cannula for Administering Eladocagene Exuparvovec to Pediatric Participants
NCT04903288AADC Deficiency
PTC Therapeutics
Phase 2
13
Massachusetts, North Carolina, Ohio, Texas
2021-05-12
Recruiting
Ventral or Inguinal Hernia, Robotically Repaired With OviTex Mesh
NCT04779918Hernia, Ventral, Hernia, Inguinal
Tela Bio Inc
Not applicable
160
Alabama, Colorado, Florida, Kansas, Kentucky, Michigan, New York, Texas
2021-04-29
Recruiting
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
NCT04752774Spasticity
Ipsen
Phase 1/2
240
California, Kansas, Michigan, Pennsylvania, Texas
2021-04-29
Recruiting
Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in Pediatric Patients With Cushing's Syndrome
NCT03708900Cushing Syndrome
RECORDATI GROUP
Phase 2
12
California, Florida, Illinois, Maryland, Texas
2021-04-28
Active, closed
A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI
NCT04825743ST-elevation Myocardial Infarction (STEMI)
CeleCor Therapeutics
Phase 3
2,463
Alaska, Michigan, Missouri, Texas
2021-04-24
Active, closed
A Study of the Natural History of Participants With LGMD2E/R4, LGMD2D/R3, LGMD2C/R5, and LGMD2A/R1 ≥ 4 Years of Age, Who Are Managed in Routine Clinical Practice
NCT04475926Limb-girdle Muscular Dystrophy
Sarepta Therapeutics, Inc.
Observational
205
Arizona, Arkansas, California, Illinois, Ohio, Oregon, Pennsylvania, Texas
2021-04-22
Active, closed
Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum
NCT04589650PIK3CA-related Overgrowth Spectrum (PROS)
Novartis Pharmaceuticals
Phase 2
206
California, Colorado, Missouri, New York, North Carolina, Ohio, Pennsylvania, Texas
2021-04-19
Active, closed
A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML
NCT04730258Acute Myeloid Leukemia, Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, AML
Treadwell Therapeutics, Inc
Phase 1/2
72
California, Kentucky, New York, Ohio, Texas
2021-04-16
Active, closed
A Study Comparing Two Doses of AGTC-501 in Male Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (SKYLINE)
NCT06333249X-Linked Retinitis Pigmentosa
Beacon Therapeutics
Phase 2
14
Florida, Massachusetts, Ohio, Oregon, Texas
2021-04-13
Recruiting
Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment
NCT04617522Advanced or Metastatic Solid Tumor, Liver Failure
Gilead Sciences
Phase 1
30
California, Delaware, Maryland, Texas
2021-04-06
Recruiting
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
NCT04728893Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia
Merck Sharp & Dohme LLC
Phase 2
490
Arkansas, California, Colorado, Kentucky, Minnesota, New Jersey, North Dakota, Texas
2021-04-05
Active, closed
Antibody Persistence And Long Term Safety Of A Chikungunya Virus Vaccine (VLA1553)
NCT04838444Chikungunya Virus Infection
Valneva Austria GmbH
Phase 3
363
Arizona, Florida, Illinois, Kentucky, Nebraska, Tennessee, Texas, Utah
2021-04-02
Recruiting
FX Shoulder Prospective Clinical Study
NCT06078865Osteoarthritis Shoulder, Rotator Cuff Syndrome of Shoulder and Allied Disorders, Fracture, Shoulder
FX Shoulder Solutions
Observational
600
Arizona, Ohio, Rhode Island, Texas
2021-03-31
Active, closed
A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors
NCT04673942Solid Tumor, Adult, Cancer, Neoplasms, Sarcoma
EpicentRx, Inc.
Phase 2
140
California, Ohio, Texas
2021-03-29
Recruiting
A Safety, Tolerability, and Efficacy Study of VX-880 and VX-017 in Participants With Type 1 Diabetes
NCT04786262Diabetes Mellitus, Type 1, Impaired Hypoglycemic Awareness, Severe Hypoglycemia
Vertex Pharmaceuticals Incorporated
Phase 3
57
California, Florida, Illinois, Maryland, Massachusetts, Pennsylvania, Texas, Virginia
2021-03-29
Active, closed
Robotic-Assisted da Vinci System Prophylactic Nipple-Sparing Mastectomy
NCT03892980Nipple Sparing Mastectomy
Intuitive Surgical
Not applicable
145
Florida, Illinois, Minnesota, New York, Pennsylvania, Texas
2021-03-26
Recruiting
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
NCT04373564Motor Function, Cognitive Function, Contrast Media
Guerbet
Phase 4
2,076
Arizona, Connecticut, Illinois, Massachusetts, Missouri, North Carolina, Pennsylvania, Texas
2021-03-24
Recruiting
Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors
NCT04665206Solid Tumor, Adult, Mesothelioma, NSCLC
Vivace Therapeutics, Inc
Phase 1/2
434
California, Illinois, Massachusetts, Minnesota, New York, Texas, Virginia
2021-03-24
Active, closed
A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis
NCT04562870Myelofibrosis
Karyopharm Therapeutics Inc
Phase 2
112
California, Colorado, Illinois, Texas
2021-03-17
Active, closed
Safety and Immunogenicity of Extended 2-dose Regimens of 9-valent Human Papillomavirus (9vHPV) Vaccine (V503-069)
NCT04708041Papillomavirus Infections
Merck Sharp & Dohme LLC
Phase 3
700
California, Florida, South Carolina, Texas, Washington
2021-03-15
Active, closed
Atrasentan in Patients With Proteinuric Glomerular Diseases
NCT04573920IgA Nephropathy, Focal Segmental Glomerulosclerosis, Alport Syndrome, Diabetic Kidney Disease
Novartis Pharmaceuticals
Phase 2
103
California, Colorado, Louisiana, Massachusetts, Minnesota, Nevada, North Carolina, Texas
2021-03-15
Recruiting
Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC
NCT04686305Locally Advanced or Metastatic Non-Small Cell Lung Cancer
AstraZeneca
Phase 1
304
California, Kansas, Maryland, Michigan, New York, Texas, Virginia, Washington
2021-03-09
Active, closed
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
NCT04486378Colorectal Cancer Stage II, Colorectal Cancer Stage III
BioNTech SE
Phase 2
327
California, Indiana, Minnesota, Ohio, Rhode Island, Tennessee, Texas, Virginia
2021-03-08
Active, closed
TH1902 in Patients With Advanced Solid Tumors
NCT04706962Solid Tumor, TNBC - Triple-Negative Breast Cancer, Hormone Receptor-positive Breast Cancer, Epithelial Ovarian Cancer
Theratechnologies
Phase 1
70
Michigan, Pennsylvania, Texas
2021-03-04
Active, closed
A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma
NCT04594642B-cell Non Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Follicular Lymphoma
AstraZeneca
Phase 1
226
Florida, Kentucky, New Jersey, North Carolina, Ohio, Pennsylvania, Texas, Wisconsin
2021-03-02
Active, closed
Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
NCT04699188KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small-Cell Lung, Carcinoma, Colorectal, Cancer of Lung
Novartis Pharmaceuticals
Phase 1/2
344
Georgia, Massachusetts, Pennsylvania, Texas
2021-02-24
Active, closed
Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcinoma
NCT04696731Advanced/Metastatic Clear Cell Renal Cell Carcinoma
Allogene Therapeutics
Phase 1
120
California, Connecticut, District of Columbia, Florida, Michigan, New York, Oregon, Texas
2021-02-24
Active, closed
Study of Intravenous (IV) ABBV-637 Alone or in Combination With IV Docetaxel/Osimertinib to Assess Adverse Events and Change in Disease Activity in Adult Participants With Relapsed/Refractory (R/R) Solid Tumors
NCT04721015Advanced Solid Tumors Cancer, Non Small Cell Lung Cancer (NSCLC)
AbbVie
Phase 1
81
Massachusetts, Missouri, North Carolina, Rhode Island, Texas, Virginia
2021-02-23
Recruiting
Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL
NCT04502394Diffuse Large B Cell Lymphoma, Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma
Kartos Therapeutics, Inc.
Phase 1/2
84
Indiana, Ohio, Texas
2021-02-23
Active, closed
A Pivotal Study of Safety and Effectiveness of NanoKnife IRE for Stage 3 Pancreatic Cancer
NCT03899636Stage III Pancreatic Cancer
Angiodynamics, Inc.
Phase 3
528
Florida, Illinois, Kentucky, Pennsylvania, Texas
2021-02-23
Active, closed
Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer
NCT04736173Non Small Cell Lung Cancer, Nonsquamous Non Small Cell Lung Cancer, Squamous Non Small Cell Lung Cancer, Lung Cancer
Arcus Biosciences, Inc.
Phase 2
169
Georgia, Texas, Virginia
2021-02-08
Active, closed
Extension Study to Evaluate the Long-Term Outcomes of Pediatric Patients Who Received Treatment for Retinopathy of Prematurity in the VGFTe-ROP-1920 Study (Acronym: Butterfleye Next)
NCT04515524Retinopathy of Prematurity
Regeneron Pharmaceuticals
Observational
100
California, New York, Ohio, Rhode Island, Texas, West Virginia
2021-02-05
Active, closed
Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer
NCT04612751Advanced or Metastatic NSCLC
AstraZeneca
Phase 1
155
California, Missouri, New Jersey, Ohio, Pennsylvania, Texas, Virginia
2021-02-02
Active, closed
Phase 2 Study Evaluating Autologous CD30.CAR-T Cells in Patients With Relapsed/Refractory Hodgkin Lymphoma (CHARIOT)
NCT04268706Hodgkin Lymphoma, Adult, Hodgkin Disease Recurrent, Hodgkin Disease Refractory, Hodgkin Disease, Pediatric
Tessa Therapeutics
Phase 2
97
California, Illinois, Pennsylvania, Tennessee, Texas
2021-02-01
Active, closed
Comparing UroLift Experience Against Rezūm
NCT04338776Benign Prostatic Hyperplasia
NeoTract, Inc.
Not applicable
120
California, Michigan, New York, Texas
2021-01-22
By invitation
A Long-term Follow-up Study in Participants Who Received CTX001
NCT04208529Beta-Thalassemia, Thalassemia, Sickle Cell Disease, Hematologic Diseases
Vertex Pharmaceuticals Incorporated
Phase 3
160
California, Illinois, New York, North Carolina, Pennsylvania, Tennessee, Texas
2021-01-20
Active, closed
Trial of ERapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance
NCT04230499Familial Adenomatous Polyposis
DrugERapa
Rapamycin Holdings Inc.
Phase 2
30
Michigan, Ohio, Texas
2021-01-18
Active, closed
A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)
NCT04628494Diffuse Large B-cell Lymphoma
Genmab
Phase 3
483
Indiana, Kentucky, Michigan, Minnesota, New Jersey, North Carolina, Ohio, Texas
2021-01-13
Recruiting
A Long-term Study Evaluating Hepatotoxicity Associated With TURALIO™ (Pexidartinib) Treatment
NCT04635111Hepatotoxicity, Tenosynovial Giant Cell Tumor
Daiichi Sankyo
Observational
30
California, Massachusetts, New York, Ohio, Texas
2021-01-07
Active, closed
A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL
NCT04521231B Cell Precursor Acute Lymphoblastic Leukemia
Amgen
Phase 1/2
181
California, Illinois, Maryland, Michigan, New York, Pennsylvania, Tennessee, Texas
2021-01-04
Active, closed
A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations
NCT04639219Advanced Solid Tumors With HER2 Mutation,eg:Colorectal,Urothelial,Gastric, Hepatobiliary,Endometrial,Melanoma,Ovarian,Cervical,Salivary Gland,Pancreatic,Breast
AstraZeneca
Phase 2
102
California, Indiana, Massachusetts, New Jersey, New York, Texas, Virginia
2020-12-30
Active, closed
Study of RP3 Monotherapy and RP3 in Combination With Nivolumab in Patients With Solid Tumours
NCT04735978Advanced Solid Tumor
Replimune, Inc.
Phase 1
123
Iowa, Pennsylvania, Texas
2020-12-29
Active, closed
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
NCT04538742Metastatic Breast Cancer
AstraZeneca
Phase 1/2
245
Florida, New York, Ohio, Tennessee, Texas, Virginia
2020-12-28
Active, closed
Study of Immune Globulin Intravenous (Human) GC5107 in Pediatric Subjects With Primary Humoral Immunodeficiency
NCT04565015Primary Immune Deficiency
GC Biopharma Corp
Phase 3
24
Colorado, Texas, Virginia
2020-12-21
Active, closed
An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors
NCT04305795Recurrent Head and Neck Squamous Cell Carcinoma, Metastatic Head-and-neck Squamous-cell Carcinoma, Locally Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
Rakuten Medical, Inc.
Phase 1/2
23
Florida, Kentucky, Minnesota, Oregon, Pennsylvania, Tennessee, Texas
2020-12-21
Active, closed
Study to Evaluate the Efficacy, Safety and Tolerability of MAS825 in Patients With Monogenic IL-18 Driven Autoinflammatory Diseases, Including NLRC4-GOF, XIAP Deficiency, or CDC42 Mutations
NCT04641442NLRC4-GOF, AIFEC (Autoinflammation With Infantile Enterocolitis), XIAP Deficiency, CDC42 Mutations
Novartis Pharmaceuticals
Phase 2
17
Ohio, Pennsylvania, Texas, Washington
2020-12-18
Active, closed
A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer
NCT04556773Metastatic Breast Cancer
AstraZeneca
Phase 1
138
New York, North Carolina, Tennessee, Texas
2020-12-17
Active, closed
A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer
NCT04351555Non-Small Cell Lung Cancer
AstraZeneca
Phase 3
358
California, Massachusetts, New Hampshire, New York, Texas, Virginia, Washington
2020-12-16
Recruiting
Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities
NCT04683250RET-altered Non Small Cell Lung Cancer, RET-altered Solid Tumors
Taiho Pharmaceutical Co., Ltd.
Phase 1/2
244
California, Massachusetts, Michigan, New York, Tennessee, Texas
2020-12-16
Active, closed
Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]
NCT04645212Wet Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration
Adverum Biotechnologies, Inc.
Observational
23
California, Colorado, Florida, Nevada, Pennsylvania, Tennessee, Texas
2020-12-14
Active, closed
Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
NCT04652882Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders
Vanda Pharmaceuticals
Phase 3
70
California, Colorado, Massachusetts, Missouri, New York, Ohio, South Carolina, Texas
2020-12-09
Active, closed
Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene
NCT04794101X-Linked Retinitis Pigmentosa
MeiraGTx Ocular UK Ltd
Phase 3
97
California, Florida, Georgia, Massachusetts, Michigan, North Carolina, Pennsylvania, Texas
2020-12-04
Recruiting
Evaluate the Continued Safety and Performance of the Foot and Ankle Products
NCT04715139Hyperpronated Foot, Reconstruction Surgeries of the Foot, Fixation of Fractures and Fusion (Bunionectomy Osteotomies) of the Foot/Ankle, Fixation of Small Bone Fragments of the Foot/Ankle
Arthrex, Inc.
Observational
700
California, Illinois, Tennessee, Texas, Virginia
2020-12-01
Recruiting
A Gene Transfer Therapy Study to Evaluate the Safety of and Expression From Delandistrogene Moxeparvovec (SRP-9001) in Participants With Duchenne Muscular Dystrophy (DMD) - Non-Ambulatory Cohort
NCT04626674Duchenne Muscular Dystrophy
Sarepta Therapeutics, Inc.
Phase 1
83
Arkansas, California, Florida, Illinois, Missouri, North Carolina, Ohio, Texas
2020-11-23
Active, closed
Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations
NCT04603001Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Chronic Myelomonocytic Leukemia (CMML), Myeloproliferative Neoplasms (MPNs)
Eli Lilly and Company
Phase 1
260
California, Florida, Illinois, Massachusetts, New York, North Carolina, Tennessee, Texas
2020-11-19
By invitation
Adherus™ Dural Sealant in Spinal Procedures
NCT04498026Spinal Duraplasty
Stryker Craniomaxillofacial
Not applicable
114
California, Florida, Illinois, Minnesota, New York, North Carolina, Pennsylvania, Texas
2020-11-19
Active, closed
FS120 Phase 1/1b Study in Patients With Advanced Malignancies
NCT04648202Advanced Cancer, Metastatic Cancer
invoX Pharma Limited
Phase 1
82
Connecticut, Texas, Utah
2020-11-18
Active, closed
Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer
NCT04592913Gastrointestinal Neoplasms, Esophagogastric Junction
AstraZeneca
Phase 3
957
California, Florida, Indiana, Kentucky, Massachusetts, New York, Tennessee, Texas
2020-11-17
Recruiting
Study of PF-07248144 in Advanced or Metastatic Solid Tumors
NCT04606446Locally Advanced or Metastatic ER+ HER2- Breast Cancer, Locally Advanced or Metastatic Castration-resistant Prostate Cancer, Locally Advanced or Metastatic Non-small Cell Lung Cancer
Pfizer
Phase 2
320
Arizona, California, Connecticut, Florida, Kentucky, Tennessee, Texas, Washington
2020-11-16
Active, closed
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
NCT04644068Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer
AstraZeneca
Phase 1/2
702
Massachusetts, New York, Oklahoma, Texas
2020-11-12
Active, closed
Safety and Tolerability Study of Oral ABBV-744 Tablet Alone or in Combination With Oral Ruxolitinib Tablet or Oral Navitoclax Tablet in Adult Participants With Myelofibrosis
NCT04454658Myelofibrosis (MF)
AbbVie
Phase 1
21
California, New Hampshire, New York, Ohio, Oklahoma, Oregon, Texas, Washington
2020-11-11
Recruiting
The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
NCT04329728Lymphoid Malignancies
AVM Biotechnology Inc
Phase 1/2
144
California, Florida, Illinois, Kentucky, Nebraska, Ohio, Tennessee, Texas
2020-11-06
Active, closed
A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies
NCT04072458Mantle Cell Lymphoma, Peripheral T-cell Lymphoma (PTCL), Cutaneous T-cell Lymphoma (CTCL), Chronic Lymphocytic Leukemia (CLL)
DrugBP1002
Bio-Path Holdings, Inc.
Phase 1
30
Georgia, New York, Tennessee, Texas
2020-11-05
Active, closed
Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)
NCT04663347Diffuse Large B-Cell Lymphoma, Follicular Lymphoma
Genmab
Phase 1/2
543
Alabama, California, Massachusetts, Michigan, New Jersey, New York, North Carolina, Texas
2020-11-03
Active, closed
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)
NCT04524871Advanced Liver Cancers
Hoffmann-La Roche
Phase 1/2
518
California, Colorado, Connecticut, District of Columbia, Kentucky, Oregon, Tennessee, Texas
2020-11-01
Active, closed
Study of Efficacy and Safety of LXH254 Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma
NCT04417621Melanoma
Novartis Pharmaceuticals
Phase 2
134
California, Florida, Massachusetts, Minnesota, New York, Pennsylvania, Texas
2020-10-30
Recruiting
A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer
NCT04516447Solid Tumor, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Phase 1
172
Colorado, Massachusetts, Missouri, New York, North Carolina, Rhode Island, Tennessee, Texas
2020-10-26
Recruiting
LymphBridge: Surgical Evaluation for Breast Cancer-Associated Lymphedema (BioBridge)
NCT04606030Lymphedema, Edema
Fibralign Corporation
Not applicable
60
Illinois, Texas
2020-10-26
Active, closed
Claudin18.2 CAR-T (CT041) in Patients With Gastric, Pancreatic Cancer, or Other Specified Digestive Cancers
NCT04404595Gastric Cancer, Pancreatic Cancer
CARsgen Therapeutics Co., Ltd.
Phase 1/2
110
California, Florida, Kansas, Michigan, Minnesota, New York, Ohio, Texas
2020-10-23
Active, closed
Study of Durvalumab Versus Placebo in Combination With Definitive Chemoradiation Therapy in Patient With ESCC
NCT04550260Esophageal Squamous Cell Carcinoma
AstraZeneca
Phase 3
640
Georgia, Kentucky, Texas, Virginia, West Virginia
2020-10-19
Active, closed
Tempus Priority Study: A Pan-tumor Observational Study
NCT05179824Breast Cancer, Prostate Cancer, Bladder Cancer, Lung Cancer
Tempus AI
Observational
1,000
Texas
2020-10-19
Active, closed
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
NCT04440189Osteoarthritis, Knee
GID BIO, Inc.
Phase 3
114
California, Florida, Louisiana, New Jersey, North Carolina, Ohio, Pennsylvania, Texas
2020-10-15
Active, closed
Less Frequent IV Dosing & Tumor Microenvironment (TME) Study of Nemvaleukin Alfa (ALKS 4230) Monotherapy and in Combination With Pembrolizumab (ARTISTRY-3)
NCT04592653Advanced Solid Tumor
Mural Oncology, Inc
Phase 1/2
78
Michigan, Texas, Utah, Virginia
2020-09-30
Active, closed
Study of AIC100 CAR T Cells in Relapsed/Refractory Thyroid Cancer
NCT04420754Anaplastic Thyroid Cancer, Relapsed/Refractory Poorly Differentiated Thyroid Cancer
AffyImmune Therapeutics, Inc.
Phase 1
70
California, Illinois, New York, Texas
2020-09-28
Active, closed
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
NCT04557449Liposarcoma, Prostate Cancer, Breast Neoplasms, Adenocarcinoma of Lung
Pfizer
Phase 2
362
California, Connecticut, Massachusetts, Michigan, Tennessee, Texas
2020-09-23
Active, closed
Open Nipple Sparing Mastectomy (NSM)
NCT04447339Nipple Sparing Mastectomy
Intuitive Surgical
Observational
75
Illinois, Minnesota, New York, Pennsylvania, Texas
2020-09-21
Active, closed
NKX101, Intravenous Allogeneic CAR NK Cells, in Adults With AML or MDS
NCT04623944Relapsed/Refractory AML, AML, Adult, MDS, Refractory Myelodysplastic Syndromes
Nkarta, Inc.
Phase 1
61
Colorado, Florida, Georgia, Illinois, Ohio, Tennessee, Texas
2020-09-21
Recruiting
A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
NCT04370587Solid Tumor, Melanoma, HNSCC, Sarcoma
DrugT3011
ImmVira Pharma Co. Ltd
Phase 1/2
30
Arizona, Massachusetts, Pennsylvania, Texas, Virginia
2020-09-17
Active, closed
Datopotamab Deruxtecan (Dato-DXd) in Combination With Pembrolizumab With or Without Platinum Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung02)
NCT04526691Advanced or Metastatic NSCLC
Daiichi Sankyo
Phase 1
145
Arizona, California, District of Columbia, Florida, Maryland, Minnesota, New Mexico, Texas
2020-09-15
Recruiting
Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3)
NCT04098744CIN 2/3, HPV Infection, Pre-Cancerous Dysplasia, Cervical Dysplasia
Frantz Viral Therapeutics, LLC
Phase 2
78
Florida, Michigan, Ohio, Texas
2020-09-09
Recruiting
Evaluate the Safety and Clinical Activity of HH2853
NCT04390737FL Lymphoma, Epithelioid Sarcoma, Peripheral T Cell Lymphoma, Advanced Solid Tumor
DrugHH2853
Haihe Biopharma Co., Ltd.
Phase 1/2
254
Arizona, Florida, Minnesota, Texas
2020-09-08
Active, closed
A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
NCT04442022Relapsed/Refractory Diffuse Large B-cell Lymphoma
Karyopharm Therapeutics Inc
Phase 2/3
501
Arizona, California, Kentucky, Maryland, New York, Texas
2020-09-03
Active, closed
A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors
NCT05593094Advanced Solid Tumors, HER2-positive Breast Cancer
Hoffmann-La Roche
Phase 1/2
210
Arizona, California, Massachusetts, Michigan, North Carolina, Texas
2020-09-03
Active, closed
Ropeginterferon Alfa-2b (P1101) vs. Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerance
NCT04285086Essential Thrombocythemia
PharmaEssentia
Phase 3
174
Arizona, Missouri, Texas, Utah
2020-08-25
Active, closed
A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors
NCT04482309Part 1: Bladder, Biliary Tract, Cervical, Endometrial, Ovarian, Pancreatic Cancer, Rare Tumors, Any Tumor Type Excluding Breast, Gastric, Colorectal Cancer, Part 2: HER2 Expressing/Amplified Solid Tumors Excluding Breast, Gastric, Colorectal Cancer
AstraZeneca
Phase 2
477
California, Illinois, Indiana, Massachusetts, New Jersey, New York, North Carolina, Texas
2020-08-18
Recruiting
A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies
NCT04503265Advanced Malignant Neoplasm, Breast Cancer, Ovarian Cancer, Homologous Recombination Deficiency
AtlasMedx, Incorporated
Phase 1/2
122
California, Maryland, Tennessee, Texas
2020-08-12
Recruiting
Non-Invasive Quantification of Liver Health in NASH (N-QUAN)
NCT04054310NASH - Nonalcoholic Steatohepatitis
Perspectum
Not applicable
225
Arizona, Illinois, Indiana, New York, Texas, Virginia
2020-08-05
Recruiting
Th-1 Dendritic Cell Immunotherapy Plus Standard Chemotherapy for Pancreatic Adenocarcinoma
NCT04157127Pancreatic Adenocarcinoma, Pancreatic Cancer, Pancreatic Adenosquamous Carcinoma
Diakonos Oncology Corporation
Phase 1
18
Texas
2020-08-03
Active, closed
Safety and Effectiveness Study of OR3O™ Dual Mobility System in THA
NCT04325022Advanced Degeneration of the Hip Joint, Revision of the Hip Joint
Smith & Nephew, Inc.
Observational
177
Kentucky, Nebraska, New York, North Carolina, Texas
2020-07-27
Active, closed
Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies
NCT04561362Urinary Bladder Neoplasm, Triple Negative Breast Neoplasms, Hormone Receptor Positive, HER2-negative Neoplasms, Hormone Receptor Positive, HER2-low Neoplasms
BicycleTx Limited
Phase 1/2
329
Colorado, Florida, New York, Ohio, Pennsylvania, Tennessee, Texas
2020-07-17
Active, closed
Linerixibat Long-term Safety, and Tolerability Study
NCT04167358Cholestasis
GlaxoSmithKline
Phase 3
242
California, Florida, Michigan, New York, North Carolina, Pennsylvania, Texas, Washington
2020-07-14
Active, closed
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:
NCT02616484Pyruvate Dehydrogenase Complex Deficiency
Saol Therapeutics Inc
Phase 3
34
California, District of Columbia, Florida, Ohio, Pennsylvania, Texas, Utah, Washington
2020-07-14
Active, closed
Efficacy and Safety of Tildrakizumab Compared to Placebo in Anti-TNF naïve Subjects With Active Psoriatic Arthritis II (INSPIRE 2)
NCT04314531Active Psoriatic Arthritis
Sun Pharmaceutical Industries Limited
Phase 3
296
California, Florida, Missouri, Nebraska, South Carolina, Texas, Washington
2020-07-01
Recruiting
A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
NCT04219254Solid Tumor, Adult
BioInvent International AB
Phase 1/2
197
California, Colorado, Minnesota, Oklahoma, Texas
2020-06-29
Recruiting
An Open-Label Study of INV-1120 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Advanced Solid Tumors
NCT04443088Cancer, Solid Tumor, Adult, Cancer Metastatic, Solid Carcinoma
Shenzhen Ionova Life Sciences Co., Ltd.
Phase 1
78
Indiana, Texas
2020-06-26
Active, closed
Study of the Safety and Effectiveness of GSK6097608 in Participants With Advanced Solid Tumors
NCT04446351Neoplasms
GlaxoSmithKline
Phase 1
107
California, Massachusetts, Texas
2020-06-25
Active, closed
Episealer® Knee System IDE Clinical Study
NCT04000659Degenerative Lesion of Articular Cartilage of Knee
Episurf Medical Inc.
Not applicable
13
Arizona, California, Louisiana, New Jersey, New York, Ohio, Tennessee, Texas
2020-06-18
Active, closed
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma
NCT04270409Plasma Cell Myeloma
Sanofi
Phase 3
337
California, Colorado, Florida, Massachusetts, North Carolina, Tennessee, Texas
2020-06-16
Active, closed
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma
NCT04106219Neuroblastoma
Eli Lilly and Company
Phase 1
71
California, Colorado, Illinois, Massachusetts, Ohio, Pennsylvania, Texas
2020-06-11
Active, closed
A Study of FCX-007 for Recessive Dystrophic Epidermolysis Bullosa
NCT04213261Recessive Dystrophic Epidermolysis Bullosa
Castle Creek Biosciences, LLC.
Phase 3
6
California, Colorado, Florida, Minnesota, Texas
2020-06-09
Active, closed
4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP)
NCT04517149X-Linked Retinitis Pigmentosa
4D Molecular Therapeutics
Phase 1/2
21
Colorado, Florida, Michigan, New York, North Carolina, Oregon, Texas, Utah
2020-06-09
Active, closed
Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)
NCT04379596Gastric Cancer
AstraZeneca
Phase 2
452
Maryland, Massachusetts, New York, Texas
2020-06-03
Active, closed
Dose Escalation Study of Intravitreal 4D-110 in Patients With Choroideremia
NCT04483440Choroideremia
4D Molecular Therapeutics
Phase 1
13
Texas, Utah
2020-06-02
Active, closed
Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
NCT04162210Multiple Myeloma
GlaxoSmithKline
Phase 3
325
Arizona, Colorado, Michigan, Nebraska, New York, Ohio, Oregon, Texas
2020-04-02
Active, closed
First-in-Human Study of ICT01 in Patients With Advanced Cancer
NCT04243499Solid Tumor, Adult, Hematopoietic/Lymphoid Cancer
ImCheck Therapeutics, an Ipsen company
Phase 1/2
293
Arizona, California, Connecticut, Florida, New York, Texas, Washington
2020-03-05
Active, closed
Study to Evaluate the Safety and Tolerability of FX201 in Patients With Osteoarthritis of the Knee
NCT04119687Osteoarthritis, Knee
Pacira Pharmaceuticals, Inc
Phase 1
72
Arizona, Florida, Missouri, Pennsylvania, Texas
2020-03-02
Active, closed
Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)
NCT04152499Epithelial Ovarian Cancer, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Urothelial Carcinoma
Klus Pharma Inc.
Phase 1/2
1,410
California, Florida, Michigan, Oklahoma, Oregon, Texas, Virginia
2020-02-28
Recruiting
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-011 in Patients With Advanced Solid Tumor
NCT04906434Advanced Liver Cancer
Abbisko Therapeutics Co, Ltd
Phase 1
200
Arizona, Florida, Minnesota, New York, Texas
2020-02-26
Active, closed
A Study Evaluating Gene Therapy With BB305 Lentiviral Vector in Sickle Cell Disease
NCT04293185Sickle Cell Disease
Genetix Biotherapeutics Inc.
Phase 3
35
Alabama, District of Columbia, Massachusetts, Minnesota, New Jersey, New York, North Carolina, Texas
2020-02-14
Recruiting
MDR - PMCF Study for Taperloc Complete Stems
NCT04028687Hip Arthritis, Hip Disease, Hip Fractures, Hip Injuries
Zimmer Biomet
Observational
820
Nevada, Texas, Washington
2020-02-13
Active, closed
DS8201a and Pembrolizumab in Participants With Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer
NCT04042701Breast Cancer, Non-small Cell Lung Carcinoma
Daiichi Sankyo
Phase 1
115
California, Connecticut, Florida, Maryland, Massachusetts, Missouri, Pennsylvania, Texas
2020-02-10
Recruiting
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in Patients With Advanced Solid Tumor
NCT04192344Neoplasms, Tenosynovial Giant Cell Tumor
Abbisko Therapeutics Co, Ltd
Phase 1
276
California, Colorado, Georgia, Texas
2020-01-20
Recruiting
Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL
NCT04260022Leukemia, Myeloid, Chronic, Myeloid Leukemia, Chronic Myeloid Leukemia, Philadelphia Positive Acute Lymphoblastic Leukemia
Ascentage Pharma Group Inc.
Phase 1
242
Alabama, California, Georgia, Maryland, Ohio, Texas, Washington
2020-01-09
Active, closed
Study to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET
NCT03972488Gastro-enteropancreatic Neuroendocrine Tumor
Advanced Accelerator Applications
Phase 3
226
Connecticut, Florida, Iowa, Kentucky, Minnesota, Texas
2020-01-08
Active, closed
A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer
NCT04077099NSCLC
Regeneron Pharmaceuticals
Phase 1/2
95
California, District of Columbia, Florida, Massachusetts, New York, Pennsylvania, Texas
2020-01-07
Recruiting
A Study of BTX-A51 in People With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome
NCT04243785Acute Myeloid Leukemia, Myelodysplastic Syndrome
Edgewood Oncology Inc.
Phase 1
80
California, New York, Texas
2020-01-06
Active, closed
Cusatuzumab in Combination With Background Therapy for the Treatment of Participants With Acute Myeloid Leukemia
NCT04150887Leukemia, Myeloid, Acute
OncoVerity, Inc.
Phase 1
61
California, Kentucky, Michigan, New York, Pennsylvania, Texas, Vermont, Wisconsin
2019-12-23
Active, closed
Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)
NCT04170153Metastatic or Locally Advanced Unresectable Solid Tumors
EMD Serono Research & Development Institute, Inc.
Phase 1
161
Massachusetts, Texas
2019-12-20
Recruiting
Medtronic Cardiac Surgery PMCF Registry
NCT04073420Valve Disease, Heart
Medtronic Cardiac Surgery
Observational
2,700
Georgia, Michigan, New York, North Carolina, Ohio, Pennsylvania, Texas, Virginia
2019-12-02
Active, closed
Zephyr Valve Registry (ZEVR)
NCT04186546Emphysema
Pulmonx Corporation
Observational
150
Alabama, Illinois, Michigan, Pennsylvania, Texas, Virginia, Wisconsin
2019-11-25
Active, closed
Study of RV001V in Biochemical Failure Following Curatively Intended Therapy For Localized Prostate Cancer
NCT04114825Prostate Cancer Recurrent
RhoVac APS
Phase 2
180
Florida, Maryland, Nebraska, Nevada, New York, South Carolina, Texas
2019-11-19
Active, closed
A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma
NCT04047251Advanced Solid Tumors, Merkel Cell Carcinoma
Fujifilm Pharmaceuticals U.S.A., Inc.
Phase 1
96
Arizona, Colorado, Massachusetts, New York, Ohio, Texas, Wisconsin
2019-11-14
Active, closed
Phase 1/1b/2 Study of Oral PMD-026 in Patients With Metastatic Breast Cancer
NCT04115306Metastatic Breast Cancer
Phoenix Molecular Designs
Phase 1/2
61
Arizona, California, Florida, Illinois, Massachusetts, Michigan, Ohio, Texas
2019-11-14
Recruiting
APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study
NCT05119842Paralysis, Unilateral, Vocal Cord
APrevent Biotech GmbH
Not applicable
30
Arizona, Maryland, Ohio, Texas
2019-11-13
Active, closed
A Study to Test Different Doses of BI 1701963 Alone and Combined With Trametinib in Patients With Different Types of Advanced Cancer (Solid Tumours With KRAS Mutation)
NCT04111458Solid Tumors, KRAS Mutation; SOS1
Boehringer Ingelheim
Phase 1
71
Massachusetts, North Carolina, Tennessee, Texas
2019-11-04
Active, closed
Rollover Study for Continued Safety and Tolerability in Subjects Treated With Spartalizumab Alone or in Combination With Other Study Treatments
NCT04058756Advanced Solid Tumors
Novartis Pharmaceuticals
Phase 1
120
New York, Oregon, Texas
2019-10-30
Active, closed
Study of Tilsotolimod in Combination With Nivolumab and Ipilimumab for the Treatment of Solid Tumors (ILLUMINATE-206)
NCT03865082Solid Tumor
Idera Pharmaceuticals, Inc.
Phase 2
30
Arizona, California, Texas
2019-10-29
Active, closed
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.
NCT04157348Eosinophilic Granulomatous Vasculitis
AstraZeneca
Phase 3
140
Colorado, Michigan, Minnesota, New Mexico, New York, Pennsylvania, Texas, Washington
2019-10-29
Active, closed
SJM Masters HP 15mm Rotatable Mechanical Heart Valve as Aortic Valve Replacement Therapy
NCT03924661Aortic Valve Disease
Abbott Medical Devices
Observational
20
California, Florida, Georgia, Mississippi, Ohio, Texas
2019-10-24
Active, closed
Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and With Pembrolizumab
NCT04130516Solid Tumor, Adult
Linnaeus Therapeutics, Inc.
Phase 1/2
200
California, Connecticut, Massachusetts, New Mexico, New York, Pennsylvania, Texas
2019-10-21
Active, closed
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia With Inhibitors
NCT04083781Haemophilia A With Inhibitors, Haemophilia B With Inhibitors
Novo Nordisk A/S
Phase 3
134
California, Georgia, Indiana, Missouri, North Carolina, Tennessee, Texas
2019-10-21
Active, closed
Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors
NCT04041310Solid Tumor, Adult
Nouscom SRL
Phase 1/2
115
California, Florida, Indiana, Maryland, Missouri, New York, Texas
2019-10-21
Recruiting
Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)
NCT04150497B-cell Acute Lymphoblastic Leukemia
Cellectis S.A.
Phase 1/2
52
California, Colorado, Illinois, Massachusetts, New York, Pennsylvania, Tennessee, Texas
2019-10-14
Active, closed
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene
NCT04123626Autosomal Dominant Retinitis Pigmentosa, Eye Diseases, Eye Diseases, Hereditary, Retinal Dystrophies
ProQR Therapeutics
Phase 1/2
11
Colorado, Florida, Kentucky, Oregon, Texas
2019-10-07
Active, closed
Predicting Responsiveness in Oncology Patients Based on Host Response Evaluation During Anti Cancer Treatments
NCT04056247Stage IV Non-small Cell Lung Cancer, Stage IV Malignant Melanoma, Stage IV Small Cell Lung Cancer, Stage III Unresectable Non-Small Cell Lung Cancer
OncoHost Ltd.
Observational
10,000
Alabama, Florida, Illinois, Iowa, New Jersey, New York, Tennessee, Texas
2019-10-01
Recruiting
Trial of DFP-14927 in Advanced Solid Tumors
NCT03943004Solid Tumor, Cancer
Delta-Fly Pharma, Inc.
Phase 1
30
California, Texas
2019-09-30
Active, closed
Clinical Trial to Evaluate Zevor-cel (CT053) in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 2)
NCT03915184Multiple Myeloma
CARsgen Therapeutics Co., Ltd.
Phase 1/2
105
Arizona, California, Colorado, Florida, Massachusetts, Minnesota, Tennessee, Texas
2019-09-25
Recruiting
A Study to Evaluate Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects
NCT03893045Iron Deficiency Anemia
AMAG Pharmaceuticals, Inc.
Phase 3
75
Arkansas, Florida, Georgia, Texas
2019-09-18
Active, closed
COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC
NCT04068610Metastatic Microsatellite-stable Colorectal Cancer
MedImmune LLC
Phase 1/2
61
California, Michigan, Nevada, New York, Ohio, Rhode Island, Tennessee, Texas
2019-09-13
Recruiting
The RESET System Pivotal Clinical Trial (Protocol Revision H)
NCT04101669Diabetes type2, Obesity
Morphic Medical Inc.
Not applicable
264
Arizona, District of Columbia, Florida, Massachusetts, Michigan, New York, Texas
2019-09-09
Active, closed
Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET
NCT03993873Advanced Solid Tumor, Metastatic Solid Tumors, MET Gene Alterations
Turning Point Therapeutics, Inc.
Phase 1
95
California, Colorado, Illinois, Massachusetts, Michigan, Missouri, Ohio, Texas
2019-09-05
Active, closed
Study of Photobiomodulation to Treat Dry Age-Related Macular Degeneration (LIGHTSITE III)
NCT04065490Dry Age-related Macular Degeneration
LumiThera, Inc.
Not applicable
96
California, Florida, Maryland, New Jersey, New York, North Carolina, Pennsylvania, Texas
2019-09-01
Recruiting
Intravesical Photodynamic Therapy ("PDT") in BCG-Unresponsive/Intolerant Non-Muscle Invasive Bladder Cancer ("NMIBC") Patients
NCT03945162Non-Muscle Invasive Bladder Cancer ("NMIBC") Unresponsive/Intolerant to BCG
Theralase® Technologies Inc.
Phase 2
90
Illinois, Indiana, New York, Ohio, Pennsylvania, South Carolina, Tennessee, Texas
2019-08-30
Active, closed
ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)
NCT04044859Endometrial Cancer, Esophageal Cancer, Esophagogastric Junction (EGJ), Gastric (Stomach) Cancer
USWM CT, LLC
Phase 1
120
Florida, Massachusetts, Missouri, New York, North Carolina, Oklahoma, Tennessee, Texas
2019-08-20
Active, closed
A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)
NCT04008030Metastatic Colorectal Cancer
Bristol-Myers Squibb
Phase 3
839
California, Colorado, Illinois, New York, Oregon, Pennsylvania, Texas, Virginia
2019-08-05
Active, closed
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients
NCT03814746Sickle Cell Disease (SCD)
Novartis Pharmaceuticals
Phase 3
254
Georgia, Massachusetts, North Carolina, Tennessee, Texas
2019-07-26
Active, closed
TARGET BP I Clinical Trial
NCT02910414Hypertension
Ablative Solutions, Inc.
Phase 3
300
Alabama, Georgia, North Carolina, Texas
2019-07-22
Active, closed
Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer
NCT04046445Colorectal Cancer, MSS, Stage IV Colon Cancer, Stage IV Rectal Cancer
Amal Therapeutics
Phase 1
96
Arizona, California, Colorado, New York, North Carolina, Texas
2019-07-22
Active, closed
Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, r/r ALL and 1L HR LBCL
NCT03960840Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Diffuse Large B-cell Lymphoma, Acute Lymphoblastic Leukemia
Novartis Pharmaceuticals
Phase 1/2
217
California, Florida, Illinois, Kansas, Massachusetts, Pennsylvania, Tennessee, Texas
2019-06-26
Recruiting
Magseed Enabled Long-Term Localization of Axillary Lymph Nodes
NCT03796559Breast Cancer, Axillary Lymph Nodes
Endomagnetics Ltd.
Not applicable
65
Texas
2019-06-13
Active, closed
An Extension Study to Evaluate Safety and Efficacy of BMN 111 in Children With Achondroplasia
NCT03989947Achondroplasia
BioMarin Pharmaceutical
Phase 2
73
California, Delaware, Georgia, Illinois, Ohio, Tennessee, Texas, Wisconsin
2019-06-12
Active, closed
SX-682 Treatment in Subjects With Metastatic Melanoma Concurrently Treated With Pembrolizumab
NCT03161431Melanoma Stage III, Melanoma Stage IV
Syntrix Biosystems, Inc.
Phase 1
77
Florida, Massachusetts, Minnesota, New York, Texas
2019-06-12
Recruiting
Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia
NCT03817502Schizophrenia
Gedeon Richter Plc.
Phase 3
330
California, Georgia, Michigan, Mississippi, New York, Ohio, Texas
2019-06-06
Recruiting
Observational, Non-Interventional Study Supporting Validation of eVO2peak Using Results in Patients Receiving Standard of Care Cardiopulmonary Exercise Tests (CPET)
NCT05678530Cardiopulmonary
Prolaio
Observational
2,000
Arizona, California, Delaware, Florida, Illinois, Minnesota, Texas, Utah
2019-06-06
By invitation
Long-term Follow-Up Study of RGX-314 and Fellow Eye Substudy
NCT03999801Neovascular Age-related Macular Degeneration, Wet Macular Degeneration
AbbVie
Phase 2
865
Arizona, California, Maryland, Massachusetts, Nevada, Pennsylvania, Tennessee, Texas
2019-05-31
Active, closed
A Clinical Trial of CK0801 (a New Drug) in Patients With Bone Marrow Failure Syndrome (BMF)
NCT03773393Bone Marrow Disease
Cellenkos, Inc.
Phase 1
18
California, Texas
2019-05-30
Active, closed
An Extension Study of IMR-687 in Adult Patients With Sickle Cell Anemia
NCT04053803Sickle Cell Disease
Imara, Inc.
Phase 2
30
Connecticut, Florida, Texas
2019-05-22
Recruiting
Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer
NCT05181826Cancer, Liver Cirrhosis, Chronic Hepatitis, Hepatitis B
Helio Genomics
Observational
1,200
California, Minnesota, Tennessee, Texas
2019-05-21
Active, closed
A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL)
NCT03930953Lymphoma, Non-Hodgkin
Celgene
Phase 1/2
438
Arizona, Florida, Kansas, Minnesota, Missouri, New Jersey, Texas
2019-05-20
Active, closed
ASP-1929 Photoimmunotherapy (PIT) Study in Recurrent Head/Neck Cancer for Patients Who Have Failed at Least Two Lines of Therapy
NCT03769506Head and Neck Cancer
Rakuten Medical, Inc.
Phase 3
135
Florida, Georgia, Kentucky, Pennsylvania, Texas
2019-05-09
Active, closed
Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas
NCT03478462Pediatric Solid Tumor, Pediatric Lymphoma, Pediatric Brain Tumor, DIPG
Cellectar Biosciences, Inc.
Phase 1
30
California, New York, North Carolina, Ohio, Texas, Wisconsin
2019-04-30
Recruiting
A Trial of Etelcalcetide in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis
NCT03633708Secondary Hyperparathyroidism, Chronic Kidney Disease
Amgen
Phase 3
56
California, Colorado, Missouri, New York, Ohio, Oklahoma, Pennsylvania, Texas
2019-04-29
Active, closed
A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors
NCT03872947Solid Tumor, Colorectal Cancer, Cholangiocarcinoma, Bladder Cancer
Toray Industries, Inc
Phase 1
138
Arizona, California, Louisiana, New Jersey, New York, Oregon, Texas, Virginia
2019-04-26
Recruiting
Clinical Pre-screening Protocol for Ovarian Cancer
NCT03877796Ovarian Cancer
Allarity Therapeutics
Observational
60
Florida, Georgia, New Mexico, New York, Oklahoma, Texas, Washington
2019-04-11
Recruiting
A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
NCT03802695Acute Myeloid Leukemia, Myelodysplastic Syndromes, Mixed Phenotype Acute Leukemia, Acute Lymphoblastic Leukemia
Orca Biosystems, Inc.
Phase 1
300
California, Florida, Georgia, Kansas, New Jersey, New York, Ohio, Texas
2019-04-08
Recruiting
Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)
NCT03666000Non-Hodgkin Lymphoma, B-cell Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Imugene Limited
Phase 1
135
Florida, Georgia, Maryland, Massachusetts, Minnesota, New York, Rhode Island, Texas
2019-03-11
Active, closed
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
NCT03768063Cancer
Hoffmann-La Roche
Phase 3
1,000
Colorado, Connecticut, Massachusetts, North Carolina, Pennsylvania, Texas
2019-02-28
Recruiting
Two Dose Levels of Privigen in Pediatric CIDP
NCT03684018Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
CSL Behring
Phase 4
30
Arizona, California, Iowa, Ohio, Pennsylvania, Tennessee, Texas, Virginia
2019-02-28
Active, closed
The CONFORMAL Early Feasibility Study
NCT03616028Non-valvular Atrial Fibrillation
Conformal Medical, Inc
Not applicable
64
Arkansas, California, New Hampshire, New York, Ohio, Pennsylvania, Tennessee, Texas
2019-02-22
By invitation
The Informed Genetics Annotated Patient Registry
NCT04419896Predisposition, Genetic
Medneon
Observational
10,000
California, Illinois, Michigan, Tennessee, Texas
2019-01-23
By invitation
Implementation of the NEDS EyeCTester App
NCT04607369Optic Nerve Disease, Macular Disease, Visual Pathway Disorder
Neuro-Eye Diagnostic Systems, LLC
Observational
100
Texas
2019-01-09
Active, closed
A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer
NCT03742102Triple Negative Breast Neoplasms
AstraZeneca
Phase 1/2
243
Arizona, Maryland, Massachusetts, Michigan, Missouri, Texas, Virginia
2018-12-21
Active, closed
Study of Durvalumab+Olaparib or Durvalumab After Treatment With Durvalumab and Chemotherapy in Patients With Lung Cancer (ORION)
NCT03775486Non-small Cell Lung Cancer NSCLC
AstraZeneca
Phase 2
401
Florida, Missouri, Pennsylvania, Tennessee, Texas
2018-12-21
Active, closed
Tramadol Versus Placebo and Morphine in the Management of Post-Operative Pain Abdominoplasty
NCT03774836Pain Management
Avenue Therapeutics, Inc.
Phase 3
360
California, Texas
2018-12-14
Active, closed
Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC
NCT03562637Triple Negative Breast Cancer
OBI Pharma, Inc
Phase 3
575
California, Florida, Illinois, Maryland, Michigan, New Jersey, Pennsylvania, Texas
2018-12-05
Active, closed
A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).
NCT03653507Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
Astellas Pharma Global Development, Inc.
Phase 3
507
California, Kansas, Louisiana, New Mexico, New York, South Carolina, Texas, Utah
2018-11-28
Active, closed
Healing Osteoarthritic Joints in the Wrist With Adult ADRCs
NCT03503305Osteoarthritis of the Wrist
InGeneron, Inc.
Not applicable
40
South Dakota, Texas
2018-11-21
Recruiting
Study to Evaluate the Safety and Efficacy of the Cytrellis Micro-Coring Device for the Treatment of Moderate to Severe Facial Wrinkles
NCT03793348Wrinkle
Cytrellis Biosystems, Inc.
Not applicable
35
California, Colorado, Florida, New York, Tennessee, Texas
2018-11-12
Active, closed
Early Weight-Bearing After the Lapiplasty Procedure
NCT03740282Hallux Valgus, Bunion
Treace Medical Concepts, Inc.
Not applicable
183
Colorado, Iowa, Missouri, Nevada, Pennsylvania, Texas
2018-11-06
Recruiting
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
NCT03588975Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee
Vericel Corporation
Phase 3
45
California, Louisiana, Maryland, Michigan, New York, Ohio, Pennsylvania, Texas
2018-10-24
Recruiting
ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease
NCT03671889Alzheimer Disease
InSightec
Not applicable
50
Florida, New York, Ohio, Texas, West Virginia
2018-09-28
By invitation
The Influence of Repairing the Sub-scapularis on Outcomes After Reverse Arthroplasty
NCT03711175Severe Arthropathy With a Grossly Deficient Rotator Cuff
Encore Medical, L.P.
Not applicable
200
Missouri, New York, Pennsylvania, Texas
2018-09-28
Active, closed
A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)
NCT03634540Renal Cell Carcinoma (RCC), Clear Cell Renal Cell Carcinoma (ccRCC), Kidney Cancer, Renal Cancer
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 2
118
California, Florida, Massachusetts, Michigan, Tennessee, Texas, Washington
2018-09-27
Active, closed
Study of Abexinostat in Patients With Relapsed or Refractory Follicular Lymphoma
NCT03600441Follicular Lymphoma
Xynomic Pharmaceuticals, Inc.
Phase 2
139
Illinois, Kentucky, New York, Pennsylvania, Texas, Washington
2018-08-27
By invitation
Long-term Follow-up of Patients Treated With Genetically Modified Autologous T Cells
NCT03628612Patients Followed for up to 15 Years Following Their First Dose of AUTO CAR T Cell Therapy, Multiple Myeloma, DLBCL, ALL, Adult and Pediatric
Autolus Limited
Phase 2
500
Florida, Missouri, Texas
2018-08-02
Active, closed
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneously Administered Guselkumab for the Treatment of Chronic Plaque Psoriasis in Pediatric Participants
NCT03451851Psoriasis
Janssen Research & Development, LLC
Phase 3
120
California, Georgia, Illinois, New Jersey, New York, Ohio, Texas
2018-07-11
Active, closed
ERG Components in Schizophrenia and Bipolar Disorder Type I
NCT03788811Schizophrenia, Bipolar I Disorder
diaMentis Inc.
Observational
300
California, Florida, Massachusetts, New Jersey, New York, Texas
2018-07-05
Active, closed
Clinical Study of Edwards Cardioband FIT Valve Repair System
NCT03382457Tricuspid Regurgitation
Edwards Lifesciences
Not applicable
75
Illinois, Minnesota, New Jersey, New York, Oregon, Pennsylvania, Texas, Utah
2018-07-01
Recruiting
A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves
NCT05110989Post Operative Pain
AtriCure, Inc.
Observational
5,000
Florida, Maryland, Missouri, New Hampshire, Ohio, Texas
2018-06-29
Active, closed
A Study of Runimotamab in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers
NCT03448042Solid Tumors
Genentech, Inc.
Phase 1
123
Connecticut, Michigan, New York, Tennessee, Texas
2018-06-06
Recruiting
Therapeutic Plantar Electrical Stimulation Intervention During Hemodialysis to Improve Balance and Mobility
NCT05407207Diabetes Mellitus, Hemodialysis Complication, Cardiovascular Complication, Quality of Life
Hamad Medical Corporation
Not applicable
100
Texas
2018-06-01
Recruiting
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
NCT03564340Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer, Recurrent Primary Peritoneal Cancer, Recurrent Endometrial Cancer
Regeneron Pharmaceuticals
Phase 1/2
890
Alabama, Massachusetts, Minnesota, New York, Ohio, Oklahoma, Tennessee, Texas
2018-05-21
Active, closed
Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study
NCT03381274Carcinoma, Non-Small-Cell Lung
MedImmune LLC
Phase 1/2
43
California, Colorado, Connecticut, Georgia, Illinois, Maryland, New York, Texas
2018-05-08
Active, closed
A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)
NCT03401788VHL - Von Hippel-Lindau Syndrome, VHL Gene Mutation, VHL Syndrome, VHL Gene Inactivation
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 2
50
Maryland, Massachusetts, Michigan, Pennsylvania, Tennessee, Texas, Utah
2018-05-02
Active, closed
THE ALIGN-AR EFS TRIAL: JenaValve Pericardial TAVR Aortic Regurgitation Study
NCT02732704Aortic Regurgitation
JenaValve Technology, Inc.
Not applicable
100
California, District of Columbia, Georgia, Michigan, New York, Texas, Washington
2018-04-20
Active, closed
Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations
NCT03316560X-Linked Retinitis Pigmentosa
Beacon Therapeutics
Phase 1/2
29
North Carolina, Ohio, Oregon, Texas
2018-04-16
Active, closed
A Phase 1 Dose-escalation Study of FF-10832 for Treatment of Solid Tumors Including Biliary Tract Cancer
NCT03440450Advanced Solid Tumors, Biliary Tract Cancer
Fujifilm Pharmaceuticals U.S.A., Inc.
Phase 1
90
Arizona, California, Colorado, Tennessee, Texas, Washington
2018-03-22
Recruiting
Collection of Sputum and Labeling for Lung Cancer
NCT03457415Lung Cancer
bioAffinity Technologies Inc.
Observational
500
New Jersey, New Mexico, Texas
2018-03-01
Recruiting
Efficacy, Safety & Utilisation of Nuwiq, Octanate and Wilate in Previously Untreated & Minimally Treated Haemophilia A Patients
NCT03695978Haemophilia A
Octapharma
Observational
200
Florida, Louisiana, Missouri, Nevada, Texas
2018-02-13
Active, closed
PARTNER 3 Trial - Mitral Valve in Valve
NCT03193801Mitral Valve Insufficiency, Mitral Valve Disease, Mitral Valve Regurgitation, Heart Failure
Edwards Lifesciences
Not applicable
53
Georgia, Illinois, Massachusetts, Minnesota, Missouri, New York, Oregon, Texas
2018-02-01
Active, closed
First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)
NCT03401385Hormone Receptor Positive Breast Cancer, Triple Negative Breast Cancer, Non-small Cell Lung Cancer
Daiichi Sankyo Co., Ltd.
Phase 1
890
California, District of Columbia, Georgia, Maryland, Massachusetts, New York, Tennessee, Texas
2018-01-31
Recruiting
Dabrafenib and/or Trametinib Rollover Study
NCT03340506Melanoma, Non Small Cell Lung Cancer, Solid Tumor, Rare Cancers
Novartis Pharmaceuticals
Phase 4
100
Arizona, Maryland, Ohio, Texas
2018-01-26
Active, closed
An Extension Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia
NCT03424018Achondroplasia
BioMarin Pharmaceutical
Phase 3
119
California, Delaware, Georgia, Illinois, Maryland, Missouri, Ohio, Texas
2017-12-12
Active, closed
Trial of Ibrutinib Plus Trastuzumab in HER2-amplified Metastatic Breast Cancer
NCT03379428Breast Neoplasms, Malignant Neoplasm of Breast
US Oncology Research
Phase 1/2
34
Texas
2017-11-29
Active, closed
Early Feasibility Study of the Orion Visual Cortical Prosthesis System
NCT03344848Blindness, Acquired
Second Sight Medical Products
Not applicable
6
California, Texas
2017-11-20
Active, closed
ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent
NCT03130777Pulmonary Disease, Transcatheter Pulmonary Valve Replacement (TPVR), Tetralogy of Fallot, Congenital Heart Disease
Edwards Lifesciences
Not applicable
86
California, Colorado, Georgia, Missouri, New York, Ohio, Pennsylvania, Texas
2017-08-22
Active, closed
Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors
NCT03313778Solid Tumors
ModernaTX, Inc.
Phase 1
161
California, District of Columbia, Florida, Massachusetts, New York, Ohio, Pennsylvania, Texas
2017-08-14
Active, closed
Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma
NCT02704858Glioblastoma Multiforme
Neonc Technologies, Inc.
Phase 1/2
49
California, Georgia, Louisiana, New Jersey, New York, North Carolina, Ohio, Texas
2017-08-01
Active, closed
Study of E7386 in Participants With Selected Advanced Neoplasms
NCT03264664Advanced Neoplasms
DrugE7386
Eisai Inc.
Phase 1
60
Arizona, California, Florida, Minnesota, Texas
2017-07-27
Active, closed
Study Evaluating Safety and Efficacy of UCART123v1.2 in Patients With Relapsed/Refractory Acute Myeloid Leukemia
NCT03190278Relapsed/Refractory Acute Myeloid Leukemia
Cellectis S.A.
Phase 1
29
California, Florida, Illinois, Massachusetts, New York, Pennsylvania, Texas
2017-06-19
Recruiting
Safety Study of MELK Inhibitor to Treat Patients With Advanced Breast Cancer and Triple Negative Breast Cancer
NCT02926690Relapsed/Refractory Locally Advanced or Metastatic Breast Cancer and Triple Negative Breast Cancer
OncoTherapy Science, Inc.
Phase 1
70
Connecticut, Georgia, Hawaii, New Hampshire, New York, Texas, Wisconsin
2017-05-29
Active, closed
Evaluation of the Personal KinetiGraph™ (PKG™) to Improve Insight Into Parkinson's Disease Status
NCT03741920Parkinson Disease
Global Kinetics Corporation
Not applicable
231
California, Florida, Kansas, Maryland, Michigan, New York, Texas
2017-05-17
Active, closed
MAGE-A4ᶜ¹º³²T for Multi-Tumor
NCT03132922Urinary Bladder Cancer, Melanoma, Head and Neck Cancer, Ovarian Cancer
USWM CT, LLC
Phase 1
71
Florida, Missouri, New York, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
2017-05-15
Active, closed
INTERCEPT Blood System for RBCs Study in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections
NCT03037164Anemia
Cerus Corporation
Phase 3
692
Arizona, Connecticut, Florida, Georgia, Maryland, Nevada, Tennessee, Texas
2017-05-11
Active, closed
Xeltis Bioabsorbable Pulmonary Valved Conduit Pivotal Study
NCT03022708Heart Defect, Congenital
Xeltis
Not applicable
6
California, Colorado, Florida, New York, Ohio, Pennsylvania, Texas
2017-05-08
Recruiting
A Feasibility Safety Study of Benign Centrally-Located Intracranial Tumors in Pediatric and Young Adult Subjects
NCT03028246Benign Centrally-Located Intracranial Tumors
InSightec
Not applicable
20
District of Columbia, Florida, Texas
2017-02-28
Active, closed
A Study of ABBV-927 and ABBV-181, an Immunotherapy, in Participants With Advanced Solid Tumors
NCT02988960Advanced Solid Tumors Cancer
AbbVie
Phase 1
163
California, Illinois, Massachusetts, North Carolina, Tennessee, Texas, Virginia
2017-02-22
Active, closed
Efficacy and Safety of 177Lu-edotreotide PRRT in GEP-NET Patients
NCT03049189Neuroendocrine Tumors
ITM Solucin GmbH
Phase 3
324
Arizona, California, Florida, Illinois, Michigan, Texas
2017-02-02
Active, closed
Venglustat in Combination With Cerezyme in Adult Patients With Gaucher Disease Type 3 With Venglustat Monotherapy Extension
NCT02843035Gaucher Disease Type 1, Gaucher Disease Type 3
Genzyme, a Sanofi Company
Phase 2
12
Connecticut, Texas, Virginia
2017-01-04
Active, closed
The Medtronic Harmony™ Transcatheter Pulmonary Valve Clinical Study
NCT02979587Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
Medtronic Heart Valves
Not applicable
86
California, Connecticut, Minnesota, Ohio, Pennsylvania, Texas, Utah, Washington
2017-01
Active, closed
An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis
NCT02808780Ulcerative Colitis
Janssen Biotech, Inc.
Observational
535
California, Florida, Georgia, Illinois, Ohio, Pennsylvania, Texas, Virginia
2016-12-16
Active, closed
An Open-Label Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib
NCT02955940Pancreatic Cancer, Colorectal Cancer (CRC), Breast Cancer, Lung Cancer
Incyte Corporation
Phase 2
10
California, Kentucky, New York, Tennessee, Texas
2016-11-30
Active, closed
A Study of LY3200882 in Participants With Solid Tumors
NCT02937272Solid Tumor
Eli Lilly and Company
Phase 1
223
Kentucky, New York, Texas
2016-11-21
Active, closed
A Study of Abemaciclib (LY2835219) Plus Tamoxifen or Abemaciclib Alone in Women With Metastatic Breast Cancer
NCT02747004Metastatic Breast Cancer
Eli Lilly and Company
Phase 2
234
Arizona, New Hampshire, Tennessee, Texas, Wisconsin
2016-09-14
Active, closed
14022 ATTUNE Cementless RP Clinical Performance Evaluation
NCT02839850Osteoarthritis
DePuy Orthopaedics
Not applicable
540
Colorado, Florida, New Hampshire, New Jersey, New York, North Carolina, Tennessee, Texas
2016-09-01
Active, closed
Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant
NCT02477878Leukemia, Myelodysplastic Syndromes, Lymphoma, Multiple Myeloma
Bellicum Pharmaceuticals
Phase 1
10
Georgia, Kansas, New York, Oregon, Texas
2016-07
By invitation
Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency
NCT02796937Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency
Grifols Therapeutics LLC
Phase 3
290
Arizona, Florida, North Carolina, Oregon, South Carolina, Texas
2016-07
Recruiting
Clinical Trial of BP1001 in Combination With With Venetoclax Plus Decitabine in AML
NCT02781883Acute Myeloid Leukemia (AML)
Bio-Path Holdings, Inc.
Phase 2
108
California, Georgia, Kansas, New Jersey, New York, Texas, West Virginia
2016-05
Active, closed
A Study of Acalabrutinib in Combination With Rituximab + (Bendamustine or Venetoclax) in Subjects With MCL
NCT02717624Mantle Cell Lymphoma (MCL)
Acerta Pharma BV
Phase 1
72
Kentucky, Michigan, New Jersey, New York, Ohio, Tennessee, Texas, Washington
2016-04-20
Active, closed
A Study of ACP-196 (Acalabrutinib) in Subjects With Relapsed/Refractory CLL and Intolerant of Ibrutinib Therapy
NCT02717611Chronic Lymphocytic Leukemia
Acerta Pharma BV
Phase 2
60
Arizona, California, District of Columbia, Illinois, New York, Ohio, Tennessee, Texas
2016-03-08
Active, closed
Open-label Study to Evaluate Long-term Safety and Efficacy of SPN-812 (Viloxazine Extended-release Capsule)
NCT02736656Attention-Deficit/Hyperactivity Disorder
Supernus Pharmaceuticals, Inc.
Phase 3
1,400
Arkansas, California, Colorado, Florida, Oklahoma, Tennessee, Texas, Utah
2016-02-02
Active, closed
A Study to Evaluate Long-Term Safety, Tolerability, & Efficacy of BMN 111 in Children With Achondroplasia (ACH)
NCT02724228Achondroplasia
BioMarin Pharmaceutical
Phase 2
30
California, Illinois, Maryland, Tennessee, Texas
2016-01-26
Active, closed
A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children
NCT02637687Solid Tumors Harboring NTRK Fusion
Bayer
Phase 1/2
154
California, Florida, Massachusetts, New York, Ohio, Pennsylvania, Tennessee, Texas
2015-12-16
Active, closed
On-X Aortic Prosthetic Heart Valve Low Dose Warfarin Post Approval Clinical Registry Study
NCT02677974Thrombotic and Bleeding Events
On-X Life Technologies, Inc.
Observational
510
Arizona, Connecticut, Indiana, Maine, North Dakota, Ohio, Oregon, Texas
2015-11-10
Active, closed
Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
NCT02542293Non Small Cell Lung Carcinoma NSCLC
AstraZeneca
Phase 3
953
California, Kentucky, New Jersey, New Mexico, New York, Ohio, Pennsylvania, Texas
2015-11-03
Recruiting
Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)
NCT01906385Glioma
Cerenome
Phase 1/2
55
New York, Texas
2015-06-03
Recruiting
A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)
NCT02332668Melanoma, Lymphoma, Solid Tumor, Classical Hodgkin Lymphoma
Merck Sharp & Dohme LLC
Phase 1/2
370
Colorado, Illinois, Massachusetts, New York, North Dakota, South Dakota, Texas
2015-03-19
Active, closed
A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations
NCT02381886Advanced Malignancies That Harbor IDHR132 Mutations
Novartis Pharmaceuticals
Phase 1
166
Massachusetts, New York, Texas
2015-03-06
Active, closed
An Open-label, Phase 2 Study of ACP-196 (Acalabrutinib) in Subjects With Mantle Cell Lymphoma
NCT02213926Mantle Cell Lymphoma (MCL)
Acerta Pharma BV
Phase 2
124
Florida, Illinois, Massachusetts, New Jersey, New York, Texas, Washington
2015-03-02
Active, closed
Study of Combined SGT-53 Plus Gemcitabine/Nab-Paclitaxel for Metastatic Pancreatic Cancer
NCT02340117Metastatic Pancreatic Cancer
SynerGene Therapeutics, Inc.
Phase 2
28
Texas
2015-01
Active, closed
An Open-label, Phase 2 Study of ACP-196 in Subjects With Waldenström Macroglobulinemia
NCT02180724Waldenström Macroglobulinemia (WM)
Acerta Pharma BV
Phase 2
107
California, Colorado, District of Columbia, Minnesota, New York, Tennessee, Texas, Washington
2014-09-11
Active, closed
Acalabrutinib in Combination With ACP-319, for Treatment of Chronic Lymphocytic Leukemia
NCT02157324Chronic Lymphocytic Leukemia
Acerta Pharma BV
Phase 1
12
Ohio, Tennessee, Texas
2014-08-18
Active, closed
A Study of JNJ-56021927 (ARN-509) and Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT02123758Prostatic Neoplasms, Metastatic Castration-Resistant Prostate Cancer
Aragon Pharmaceuticals, Inc.
Phase 1
57
California, Texas
2014-07-09
Active, closed
Persona Total Knee Arthroplasty Outcomes Study
NCT02255383Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
Zimmer Biomet
Not applicable
737
Colorado, Illinois, Indiana, North Carolina, Ohio, Pennsylvania, Tennessee, Texas
2014-07
Active, closed
Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant
NCT03301168Acute Lymphoblastic Leukemia, Leukemia, Acute Myeloid (AML), Child, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes
Bellicum Pharmaceuticals
Phase 1/2
120
California, District of Columbia, Georgia, Massachusetts, New York, Oregon, Texas, Washington
2014-04
Active, closed
ACP-196 (Acalabrutinib), a Novel Bruton Tyrosine Kinase (BTK) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia
NCT02029443Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Richter's Syndrome, Prolymphocytic Leukemia
Acerta Pharma BV
Phase 1/2
306
Massachusetts, New York, Ohio, Texas, Utah, Washington
2014-01-30
Active, closed
Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV
NCT02016924Acquired Immune Deficiency Syndrome (AIDS), HIV Infections
Gilead Sciences
Phase 2/3
133
California, Colorado, District of Columbia, Florida, Tennessee, Texas
2014-01-16
Active, closed
Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer
NCT01872260Breast Cancer
Novartis Pharmaceuticals
Phase 1/2
259
California, Florida, Massachusetts, Tennessee, Texas, Washington
2013-10-22
Active, closed
Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant
NCT01744223Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Lymphoma, Myelodysplastic Syndromes
Bellicum Pharmaceuticals
Phase 1/2
36
Georgia, New York, Ohio, Oregon, Texas, Washington
2013-03
Active, closed
Survivorship of Attune Primary Total Knee Prosthesis
NCT01754363Noninflammatory Degenerative Joint Disease
DePuy International
Not applicable
1,542
Arizona, California, Florida, Indiana, Iowa, Ohio, Pennsylvania, Texas
2013-02-01
Active, closed
Study to Evaluate the Antiviral Efficacy, Safety and Tolerability of Tenofovir Disoproxil Fumarate Versus Placebo in Pediatric Participants With Chronic Hepatitis B Infection
NCT01651403Chronic Hepatitis B
Gilead Sciences
Phase 3
90
Arizona, California, Colorado, Ohio, Texas
2012-12-06
Active, closed
DelIVery for Pulmonary Arterial Hypertension (PAH) & Continued Support Study
NCT01321073Pulmonary Arterial Hypertension
Medtronic Cardiac Rhythm and Heart Failure
Not applicable
64
Alabama, California, Florida, Illinois, Massachusetts, Minnesota, Texas, Wisconsin
2011-06
Active, closed
Global Registry for Endovascular Aortic Treatment (GREAT)
NCT01658787Multiple Pathologies
W.L.Gore & Associates
Observational
4,600
Illinois, Texas
2010-12
Recruiting
Global Patient Registry to Monitor Long-term Safety and Effectiveness of Increlex® in Children and Adolescents With Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD).
NCT00903110IGF1 Deficiency
Esteve Pharmaceuticals, S.A.
Observational
500
California, Florida, Ohio, Texas
2008-12-09
Rows per page Showing 1501–1965 of 1965
Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 6 October 2026. https://priyalifescience.com/clinical-trials-usa/state/texas?page=4

Query this register directly
GET /api/trials?country=usa&status=recruiting&format=json Try it now →

About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,118 studies in total at the last sync on 06 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 1,965 of those studies with a site in Texas.

How many clinical trials are recruiting in Texas?

1,184 of the 1,965 studies on this page are recruiting new participants as of the 06 Oct 2026, 03:16 UTC sync. A further 101 have not yet opened recruitment, 623 are active but closed to new participants, and 57 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.