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Trackers› Clinical trials› Colorado
Clinical trial register · United States · industry-sponsored

Clinical Trials in Colorado, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9122 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 07 Oct 2026, 03:16 UTC
9122
Studies in scope
industry-sponsored, all four open statuses
4946
Recruiting now
open to new participants
2190
Lead sponsors
across recruiting studies
Top states
California 5298 Florida 4435 Illinois 2485 Georgia 2368 Arizona 2240
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
AstraZeneca87 Janssen Research & Development, LLC71 Eli Lilly and Company65 Merck Sharp & Dohme LLC64 Novartis Pharmaceuticals56
State
California5298 Florida4435 Illinois2485 Georgia2368 Arizona2240
All 51 states
Target enrolment
to

Trials with a site in Colorado

2073 of 9122 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Active, closed
A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors
NCT05159700Advanced Solid Tumor, Advanced Solid Malignancies
DrugPRJ1-3024
Zhuhai Yufan Biotechnologies Co., Ltd
Phase 1
39
Colorado, Florida, Ohio, Texas, Virginia
2022-03-31
Recruiting
4D-710 in Adult Patients With Cystic Fibrosis
NCT05248230Cystic Fibrosis Lung
4D Molecular Therapeutics
Phase 2
30
Alabama, Arizona, California, Colorado, Florida, Illinois, Kansas, Maryland
2022-03-29
Active, closed
Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)
NCT05270668Diffuse Cutaneous Systemic Sclerosis, Interstitial Lung Disease
DrugTulisokibart
Prometheus Biosciences, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 2
154
Arizona, California, Colorado, Connecticut, District of Columbia, Maryland, Massachusetts, Michigan
2022-03-29
Active, closed
Long-term Follow-up Study of Risdiplam in Participants With Spinal Muscular Atrophy (SMA)
NCT05232929Spinal Muscular Atrophy
DrugRisdiplam
Genentech, Inc.
Phase 4
403
Arizona, Arkansas, California, Colorado, District of Columbia, Florida, Georgia, Kentucky
2022-03-29
Active, closed
LF111 or Drospirenone Chew vs Non-hormonal Contraceptive Methods on Bone Mineral Density in Adolescent and Adult Women
NCT05303636Change in Bone Mineral Density, Bone Loss
DrugDrospirenone
Insud Pharma
Phase 4
1,536
Arizona, Colorado, Florida, Louisiana, Michigan, Nebraska, North Dakota, Pennsylvania
2022-03-28
Active, closed
Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)
NCT05348577Prostate Cancer
DrugsCapivasertib·Docetaxel
AstraZeneca
Phase 3
1,035
Arizona, California, Colorado, Maryland, Minnesota, New Jersey, New York, Ohio
2022-03-25
Active, closed
A Research Study on How Well Concizumab Works for You if You Have Haemophilia A or B With or Without Inhibitors
NCT05135559Haemophilia A and B With and Without Inhibitors
DrugConcizumab
Novo Nordisk A/S
Phase 3
153
California, Colorado, Florida, Georgia, Illinois, Indiana, Louisiana, Missouri
2022-03-24
Active, closed
Non-Guided vs. Guided Surgery to Immediately Loaded PrimeTaper Implants in Partially Edentulous Patients
NCT05264545Partially Edentulous Maxilla or Mandible
McGuire Institute
Not applicable
100
Colorado, Illinois, Nebraska, Tennessee, Texas, Washington, Wisconsin
2022-03-22
By invitation
Long-Term Follow-up Study
NCT05332054Lymphoma, Non-Hodgkin, Relapsed Non-Hodgkin Lymphoma, Refractory B-Cell Non-Hodgkin Lymphoma, Non-Hodgkin Lymphoma
Caribou Biosciences, Inc.
Observational
150
Alabama, Arizona, California, Colorado, Florida, Georgia, Iowa, Kentucky
2022-03-16
Active, closed
Trial of Sibeprenlimab in the Treatment of A Nephropathy (IgAN)
NCT05248646Immunoglobulin A Nephropathy
DrugSibeprenlimab
Otsuka Pharmaceutical Development & Commercialization, Inc.
Phase 3
530
Alabama, Arizona, Arkansas, California, Colorado, Florida, Georgia, Iowa
2022-03-15
Active, closed
A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)
NCT05239728Carcinoma, Renal Cell
DrugsBelzutifan·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,800
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Indiana, Maryland
2022-03-15
Active, closed
Abemaciclib (LY2835219) Plus Fulvestrant Compared to Placebo Plus Fulvestrant in Previously Treated Breast Cancer
NCT05169567Breast Neoplasm, Neoplasm Metastasis
DrugsAbemaciclib·Fulvestrant
Eli Lilly and Company
Phase 3
368
Arizona, Arkansas, California, Colorado, Florida, Georgia, Hawaii, Illinois
2022-03-11
Active, closed
A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.
NCT05064878CDKL5 Deficiency Disorder, Generalized Tonic Clonic Seizure, Epileptic Spasm, Refractory Seizures
DrugFintepla
Zogenix, Inc.
Phase 3
87
Alabama, California, Colorado, District of Columbia, Georgia, Massachusetts, Michigan, North Carolina
2022-03-08
Active, closed
Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations
NCT05215340Metastatic Non Small Cell Lung Cancer
DrugsDato-DXd·Keytruda·Pembrolizumab
Daiichi Sankyo
Phase 3
740
Arizona, California, Colorado, Maryland, Massachusetts, New Hampshire, New Jersey, New York
2022-03-04
Active, closed
A Study to Investigate Faricimab Treatment Response in Treatment-Naive, Underrepresented Patients With Diabetic Macular Edema
NCT05224102Diabetic Macular Edema
DrugsVabysmo·Faricimab
Genentech, Inc.
Phase 4
218
Arizona, California, Colorado, District of Columbia, Florida, Illinois, Maryland, Michigan
2022-02-28
Recruiting
Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects
NCT05156398Migraine
DrugRimegepant
Pfizer
Phase 3
640
Arkansas, California, Colorado, District of Columbia, Florida, Georgia, Idaho, Illinois
2022-02-28
Recruiting
A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)
NCT04988555Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Acute, Multiple Myeloma, Myelodysplastic Syndromes
DrugsAzoles·Gilteritinib·Azacitidine·Venetoclax
Sumitomo Pharma America, Inc.
Phase 1/2
606
California, Colorado, District of Columbia, Florida, Illinois, Maryland, Massachusetts, New Jersey
2022-02-28
Active, closed
Clinical Study Of a Micro-Implantable Pulse Generator For The Treatment of Peripheral Neuropathic Pain
NCT05287373Peripheral Neuralgia, Chronic Pain
Nalu Medical, Inc.
Not applicable
89
Arizona, Arkansas, California, Colorado, District of Columbia, North Carolina, Oregon, Texas
2022-02-23
Active, closed
Setrusumab vs Placebo for Osteogenesis Imperfecta
NCT05125809Osteogenesis Imperfecta
DrugSetrusumab
Ultragenyx Pharmaceutical Inc
Phase 2/3
183
Arkansas, California, Colorado, Connecticut, Delaware, District of Columbia, Florida, Illinois
2022-02-21
Active, closed
A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour Resection
NCT05120349Non-Small Cell Lung Cancer
DrugsTagrisso·Osimertinib
AstraZeneca
Phase 3
390
Alaska, California, Colorado, Delaware, Georgia, Illinois, Maryland, New Jersey
2022-02-21
Recruiting
A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer
NCT05128825High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer
DrugAzenosertib
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Phase 2
310
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2022-02-17
Active, closed
A Masked, Placebo-controlled Study to Assess Iptacopan in Age-related Macular Degeneration
NCT05230537Age-Related Macular Degeneration
DrugIptacopan
Novartis Pharmaceuticals
Phase 2
168
California, Colorado, Florida, Indiana, Louisiana, Maryland, Massachusetts, New Jersey
2022-02-17
Active, closed
A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema
NCT05121376Hereditary Angioedema, HAE
BioMarin Pharmaceutical
Phase 1/2
44
Alabama, Arizona, California, Colorado, Kansas, Maryland, Mississippi, Missouri
2022-02-15
Active, closed
P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid Tumors
NCT05239143Breast Cancer, Ovarian Cancer, Non Small Cell Lung Cancer, Colorectal Cancer
DrugRimiducid
Poseida Therapeutics, Inc.
Phase 1
180
California, Colorado, Iowa, Kansas, Maryland, Massachusetts, Nebraska, New York
2022-02-15
Active, closed
A Study of a Patient-Specific Neoantigen Vaccine in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer
NCT05141721Colorectal Neoplasms
DrugsFluoropyrimidine·Yervoy·Tecentriq·Avastin
Seattle Project Corporation
Phase 2/3
700
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Illinois, Indiana
2022-02-12
Active, closed
Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc
NCT05258435Cervical Disc Disease, Degenerative Disc Disease
NuVasive
Observational
131
California, Colorado, Florida, Illinois, Indiana, Louisiana, North Carolina, Texas
2022-02-09
Recruiting
InSpace Accelerated Rehabilitation Study
NCT05329584Rotator Cuff Tears
Stryker Endoscopy
Not applicable
160
Arizona, Arkansas, Colorado, Florida, Georgia, Illinois, Minnesota, New York
2022-02-07
Active, closed
A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Disease (MOGAD)
NCT05063162Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD)
DrugRozanolixizumab
UCB Biopharma SRL
Phase 3
113
Arizona, California, Colorado, District of Columbia, Florida, Illinois, Maryland, Massachusetts
2022-02-02
Active, closed
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab Monotherapy in Participants With Select B-Cell Malignancies
NCT05207670Non-Hodgkin Lymphoma
DrugsMosunetuzumab·Tocilizumab
Genentech, Inc.
Phase 2
320
Alabama, Alaska, Arizona, California, Colorado, Delaware, Florida, Iowa
2022-02-01
Active, closed
ADH1 and ADH2 Disease Monitoring Study (DMS)
NCT05227287Autosomal Dominant Hypocalcemia
Calcilytix Therapeutics, Inc., a BridgeBio company
Observational
95
California, Colorado, Florida, Indiana, Massachusetts, Minnesota, North Carolina, Ohio
2022-01-20
Active, closed
A Study of Guselkumab Subcutaneous Therapy in Participants With Moderately to Severely Active Crohn's Disease
NCT05197049Crohn Disease
DrugsGuselkumab 1·Guselkumab 2·Guselkumab 3
Janssen Research & Development, LLC
Phase 3
350
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia
2022-01-19
By invitation
Long-term Extension Study to Assess Safety and Tolerability of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Pediatric Participants (Ages 6-17)
NCT05127954Migraine
DrugUbrogepant
AbbVie
Phase 3
1,200
Alabama, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida, Georgia
2022-01-14
Active, closed
Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD
NCT05407636AMD, nAMD, Wet Age-related Macular Degeneration, wAMD
DrugsEylea·Aflibercept
AbbVie
Phase 3
735
Arizona, California, Colorado, Connecticut, Florida, Georgia, Hawaii, Illinois
2022-01-13
Recruiting
Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)
NCT05125302Migraine
DrugUbrogepant
AbbVie
Phase 3
1,059
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2022-01-13
Recruiting
A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)
NCT05118789Locally Advanced Solid Tumor, Metastatic Solid Tumor
Nuvalent Inc.
Phase 1/2
359
California, Colorado, District of Columbia, Florida, Illinois, Massachusetts, Michigan, Missouri
2022-01-04
Recruiting
Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II
NCT05102019Refractory Angina
Shockwave Medical, Inc.
Not applicable
380
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2022-01-04
Active, closed
Study of Tirabrutinib (ONO-4059) in Patients With Primary Central Nervous System Lymphoma (PROSPECT Study)
NCT04947319Refractory Primary Central Nervous System Lymphoma, Primary CNS Lymphoma
DrugTirabrutinib
Ono Pharmaceutical Co., Ltd.
Phase 2
119
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia
2021-12-29
Active, closed
HALOS: A Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Multiple Ascending Doses of ION582 in Participants With Angelman Syndrome
NCT05127226Angelman Syndrome
DrugObudanersen
Ionis Pharmaceuticals, Inc.
Phase 1/2
71
California, Colorado, Illinois, Massachusetts, North Carolina, Texas
2021-12-22
Active, closed
Rho Kinase Inhibitor in Amyotrophic Lateral Sclerosis (REAL)
NCT05218668Amyotrophic Lateral Sclerosis
DrugFasudil
Woolsey Pharmaceuticals
Phase 2
40
Arizona, Colorado, Florida, Illinois, Kentucky, Missouri, New York
2021-12-22
Active, closed
Targeted Alpha-emitter Therapy of PRRT Naïve and Previous PRRT Neuroendocrine Tumor Patients
NCT05153772Neuroendocrine Tumors
Orano Med LLC
Phase 2
69
Colorado, Florida, Louisiana, Texas
2021-12-21
Active, closed
Lutetium 177Lu-Edotreotide Versus Best Standard of Care in Well-differentiated Aggressive Grade-2 and Grade-3 GastroEnteroPancreatic NeuroEndocrine Tumors (GEP-NETs) - COMPOSE
NCT04919226Neuroendocrine Tumors
DrugsFOLFOX (Folinic acid·Everolimus·Fluorouracil·Oxaliplatin
ITM Solucin GmbH
Phase 3
259
California, Colorado, Florida, Massachusetts, Minnesota, Missouri, New York, North Carolina
2021-12-21
Active, closed
Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
NCT05123755Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral
Vasomune Therapeutics, Inc.
Phase 2
60
California, Colorado, Illinois, Maryland, Michigan, Ohio
2021-12-20
Active, closed
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-1)
NCT05147220Relapsing Multiple Sclerosis
DrugsTeriflunomide·Remibrutinib
Novartis Pharmaceuticals
Phase 3
1,000
Arizona, Arkansas, California, Colorado, Delaware, District of Columbia, Florida, Illinois
2021-12-16
By invitation
Long-Term Follow-Up Study After Gene-Modified Cell Treatment in Kite Studies
NCT05041309Solid and Hematological Malignancies, Autoimmune Diseases
DrugsKITE-197·SPRX002·KITE-753·Tecartus
Kite, A Gilead Company
Observational
1,500
Arizona, California, Colorado, District of Columbia, Florida, Illinois, Iowa, Kansas
2021-12-15
Active, closed
A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis
NCT05070858Generalized Myasthenia Gravis
DrugsCemdisiran·Pozelimab
Regeneron Pharmaceuticals
Phase 3
288
Arizona, California, Colorado, Florida, Illinois, Michigan, Ohio, Pennsylvania
2021-12-14
Recruiting
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
NCT05176483Renal Cell Carcinoma (RCC), Metastatic Castration-Resistant Prostate Cancer (mCRPC), Urothelial Carcinoma (UC), Solid Tumor
DrugsZanzalintinib·Relatlimab·Yervoy·Ipilimumab
Exelixis
Phase 1
1,394
Arizona, California, Colorado, Connecticut, Delaware, Florida, Illinois, Indiana
2021-12-14
Recruiting
A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)
NCT04853251Neovascular Age-related Macular Degeneration
DrugsLucentis·Ranibizumab
Genentech, Inc.
Phase 4
188
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa
2021-12-14
Active, closed
Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)
NCT04954859Hepatitis B
DrugBepirovirsen
GlaxoSmithKline
Phase 2
360
California, Colorado, Massachusetts, Michigan
2021-12-14
Active, closed
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2)
NCT05156281Relapsing Multiple Sclerosis
DrugsTeriflunomide·Remibrutinib
Novartis Pharmaceuticals
Phase 3
1,007
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Indiana, Kansas
2021-12-13
Recruiting
4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
NCT05197270Neovascular (Wet) Age-Related Macular Degeneration
DrugsAflibercept IVT·4D-150 IVT
4D Molecular Therapeutics
Phase 1/2
215
Arizona, California, Colorado, Florida, Illinois, Indiana, Maryland, Massachusetts
2021-12-09
Recruiting
First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer
NCT05216432PIK3CA Mutation, Solid Tumor, Adult, HER2-negative Breast Cancer, Breast Cancer
DrugsRLY-2608·Atirmociclib·Ribociclib·Palbociclib
Relay Therapeutics, Inc.
Phase 1
930
Arizona, California, Colorado, Connecticut, Florida, Illinois, Indiana, Massachusetts
2021-12-08
Active, closed
PATHFINDER 2: A Multi-Cancer Early Detection Study
NCT05155605Early Detection of Cancer, Cancer
GRAIL, Inc.
Not applicable
35,883
California, Colorado, District of Columbia, Florida, Georgia, Illinois, Louisiana, Maryland
2021-12-08
By invitation
Extension Study of Infigratinib in Children With Achondroplasia (ACH)
NCT05145010Achondroplasia
DrugInfigratinib
QED Therapeutics, a BridgeBio company
Phase 2
300
California, Colorado, Delaware, Maryland, Missouri, Ohio, Tennessee, Wisconsin
2021-12-06
Recruiting
(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT04910685Indolent Systemic Mastocytosis, Smoldering Systemic Mastocytosis
Blueprint Medicines Corporation
Phase 2/3
534
Alabama, California, Colorado, Georgia, Massachusetts, Michigan, Minnesota, New York
2021-11-30
Active, closed
Long-Chain Fatty Acid Oxidation Disorders In-Clinic Disease Monitoring Program
NCT04632953Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)
Ultragenyx Pharmaceutical Inc
Observational
150
Arizona, California, Colorado, Florida, Georgia, Illinois, Massachusetts, Minnesota
2021-11-30
Recruiting
Pediatric Post-Approval Registry
NCT04457154Obstructive Sleep Apnea
Inspire Medical Systems, Inc.
Observational
60
Colorado, Georgia, North Carolina, Ohio, Pennsylvania, Texas, Virginia
2021-11-30
Active, closed
Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease
NCT05030428Atherosclerotic Cardiovascular Disease
DrugInclisiran sodium
Novartis Pharmaceuticals
Phase 3
17,004
Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia
2021-11-23
Recruiting
Knee Related Subchondral Bone Lesions Treated With IOBP
NCT05314608Subchondral Cyst
Arthrex, Inc.
Observational
100
Colorado, Florida, Maryland, Ohio, Pennsylvania
2021-11-17
Active, closed
Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT05089734Non-Small Cell Lung Cancer
DrugsSacituzumab Govitecan·Docetaxel
Gilead Sciences
Phase 3
603
Alaska, Arizona, California, Colorado, Florida, Illinois, Iowa, Kansas
2021-11-17
Active, closed
A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure
NCT04988295Carcinoma, Non-Small-Cell Lung
DrugsLazertinib·Amivantamab·Pemetrexed·Carboplatin
Janssen Research & Development, LLC
Phase 3
776
Alabama, Arizona, California, Colorado, Florida, Georgia, Mississippi, Nebraska
2021-11-17
Active, closed
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pediatric Participants With Atypical Hemolytic Uremic Syndrome (aHUS)
NCT04958265Atypical Hemolytic Uremic Syndrome
DrugCrovalimab
Hoffmann-La Roche
Phase 3
41
Colorado, Nebraska, New Jersey
2021-11-17
Active, closed
A Study of Lu AF82422 in Participants With Multiple System Atrophy
NCT05104476Multiple System Atrophy
DrugAmlenetug
H. Lundbeck A/S
Phase 2
64
California, Colorado, Florida, Illinois, Massachusetts, Minnesota, Nebraska, New York
2021-11-16
Active, closed
Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy
NCT05112237Cardiomyopathy
Tenaya Therapeutics
Observational
200
Arkansas, California, Colorado, Delaware, Florida, Missouri, New York, Ohio
2021-11-01
Active, closed
AlloSure Lung Assessment and Metagenomics Outcomes Study
NCT05050955Lung Transplant Infection, Lung Transplant; Complications, Lung Transplant Failure and Rejection
CareDx
Observational
550
Alabama, Arizona, California, Colorado, Florida, Illinois, Kentucky, Maryland
2021-10-29
Active, closed
Pyrocarbon Clinical Follow-up Study
NCT05049993Osteoarthritis of the Shoulder, Avascular Necrosis, Traumatic Arthritis
Stryker Trauma and Extremities
Observational
76
Colorado, Florida, Louisiana, Maryland, Minnesota, Missouri, North Carolina, Oregon
2021-10-27
Active, closed
Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants
NCT04988386Amyloid Cardiomyopathy, Transthyretin-Related
DrugAcoramidis
Eidos Therapeutics, a BridgeBio company
Phase 3
389
California, Colorado, Illinois, Maryland, Massachusetts, Minnesota, Missouri, New York
2021-10-27
Active, closed
Harmony TPV Post-Approval Study
NCT05077774Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
Medtronic Cardiovascular
Not applicable
174
Alabama, California, Colorado, Florida, Illinois, Massachusetts, Michigan, Missouri
2021-10-25
Recruiting
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
NCT04929223Metastatic Colorectal Cancer
DrugsDivarasib·Tiragolumab·Inavolisib·Folfiri
Hoffmann-La Roche
Phase 1
542
Alabama, Arizona, California, Colorado, Connecticut, Florida, Illinois, Louisiana
2021-10-22
Active, closed
A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET
NCT05050942Gastro-enteropancreatic Neuroendocrine Tumor
DrugsCAM2029·Octreotide LAR
Camurus AB
Phase 3
332
Arizona, California, Colorado, Florida, Kentucky, Louisiana, Massachusetts, Minnesota
2021-10-22
Active, closed
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS)
NCT04861259Atypical Hemolytic Uremic Syndrome
DrugCrovalimab
Hoffmann-La Roche
Phase 3
83
California, Colorado, Georgia, Missouri, Ohio, Texas
2021-10-22
Active, closed
Osteosarcoma Maintenance Therapy With OST31-164
NCT04974008Bone Cancer
Emerald Clinical Inc.
Phase 2
39
California, Colorado, Connecticut, Delaware, Florida, Georgia, Illinois, Maryland
2021-10-21
Active, closed
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
NCT05198674Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
Medtronic Vascular
Not applicable
1,899
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2021-10-20
Active, closed
Study of Vimseltinib for Tenosynovial Giant Cell Tumor
NCT05059262Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor, Diffuse
DrugVimseltinib
Deciphera Pharmaceuticals, LLC
Phase 3
123
California, Colorado, Kansas, Massachusetts, Minnesota, New York, North Carolina, Ohio
2021-10-14
Active, closed
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab
NCT05029882Non-Small Cell Lung Cancer, Advanced Solid Tumors, Gastroesophageal Adenocarcinoma, Colorectal Cancer
DrugsTelisotuzumab Adizutecan·Trifluridine/Tipiracil·Bevacizumab
AbbVie
Phase 1
520
California, Colorado, Connecticut, Illinois, Indiana, Louisiana, Michigan, New York
2021-10-13
Recruiting
PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR
NCT04889872Aortic Stenosis, Calcific, Aortic Valve Stenosis
Edwards Lifesciences
Not applicable
2,250
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Idaho
2021-10-12
Active, closed
A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP
NCT04971226Chronic Myeloid Leukemia (CML) Philadelphia Chromosome Positive
DrugsBosutinib·Asciminib·ABL001·Nilotinib
Novartis Pharmaceuticals
Phase 3
405
Colorado, Florida, Kentucky, Massachusetts, North Carolina, Oregon, South Dakota, Tennessee
2021-10-06
Active, closed
Study Evaluating the Safety and Efficacy of Islatravir in Combination With Lenacapavir in Virologically Suppressed People With HIV
NCT05052996HIV-1 Infection
DrugsB/F/TAF·Lenacapavir
Gilead Sciences
Phase 2
142
California, Colorado, District of Columbia, Florida, Georgia, Hawaii, Illinois, Indiana
2021-10-05
Recruiting
A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments
NCT05020236Multiple Myeloma
DrugsDarzalex·Elranatamab·Pomalidomide·Daratumumab
Pfizer
Phase 3
893
California, Colorado, Florida, Louisiana, New Jersey, New York
2021-10-04
Active, closed
A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer
NCT04975308Breast Neoplasms, Neoplasm Metastasis
DrugsImlunestrant·Exemestane·Abemaciclib·Fulvestrant
Eli Lilly and Company
Phase 3
874
Arizona, California, Colorado, Florida, Hawaii, Illinois, Indiana, Kentucky
2021-10-04
Recruiting
A Study of NX-1607 in Adults With Advanced Malignancies
NCT05107674Ovarian Cancer, Epithelial, Gastric Cancer, GastroEsophageal Junction (GEJ) Cancer, Head and Neck Squamous Cell Carcinoma
DrugPaclitaxel
Nurix Therapeutics, Inc.
Phase 1
345
California, Colorado, Illinois, North Carolina, Oklahoma, Texas, Virginia, Washington
2021-09-29
Active, closed
Study of INBRX-109 in Conventional Chondrosarcoma
NCT04950075Conventional Chondrosarcoma
DrugINBRX-109
Inhibrx Biosciences, Inc
Phase 2
206
Arizona, California, Colorado, Connecticut, Florida, Illinois, Iowa, Maryland
2021-09-23
Active, closed
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis
NCT05050136Primary Biliary Cholangitis, PBC
DrugVolixibat
Mirum Pharmaceuticals, Inc.
Phase 2
333
California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa, Louisiana
2021-09-22
Active, closed
A Study of Talquetamab With Other Anticancer Therapies in Participants With Multiple Myeloma
NCT05050097Multiple Myeloma
DrugsTalquetamab·Carfilzomib·Pomalidomide·Daratumumab
Janssen Research & Development, LLC
Phase 1
166
Alabama, California, Colorado, Georgia, Indiana, New Jersey, New York, North Carolina
2021-09-22
Recruiting
A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy
NCT04557462Primary IgA Nephropathy
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
540
Arizona, California, Colorado, Delaware, Idaho, Illinois, Maryland, Massachusetts
2021-09-20
Active, closed
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
NCT04909801Rheumatoid Arthritis
DrugsAbatacept·Humira·Adalimumab·Methotrexate
Bristol-Myers Squibb
Phase 3
338
California, Colorado, Maryland, Minnesota, New Jersey, New York, North Carolina, Oregon
2021-09-15
Recruiting
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
NCT05006716B-cell Malignancy, Marginal Zone Lymphoma, Follicular Lymphoma, Non-Hodgkin Lymphoma
DrugTacabrutideg
BeOne Medicines
Phase 1/2
689
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Iowa
2021-09-13
Active, closed
Study of Selinexor Plus DRd for Newly Diagnosed Multiple Myeloma
NCT04782687Multiple Myeloma, Myeloma Multiple, Kahler Disease, Myeloma, Plasma Cell
DrugsDarzalex·Selinexor·Daratumumab·Lenalidomide
US Oncology Research
Phase 2
73
Arizona, Colorado, Maryland, New York, Oregon, Texas, Virginia
2021-09-10
Recruiting
ZEN003694 and Enzalutamide Versus Enzalutamide Monotherapy in Metastatic Castration-Resistant Prostate Cancer
NCT04986423Metastatic Castration-Resistant Prostate Cancer
DrugsZEN003694·Xtandi·Enzalutamide
Zenith Epigenetics
Phase 2
200
California, Colorado, Florida, Louisiana, Maryland, Michigan, New York, North Carolina
2021-09-08
Recruiting
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
NCT05059444Bladder Carcinoma, Ureter Carcinoma, Renal Pelvis Carcinoma, Non-small Cell Lung Cancer
Guardant Health, Inc.
Observational
2,285
Alabama, Arizona, Arkansas, California, Colorado, Florida, Louisiana, Maine
2021-09-07
Recruiting
Quaratusugene Ozeplasmid (Reqorsa) and Osimertinib in Patients With Advanced Lung Cancer Who Progressed on Osimertinib
NCT04486833Carcinoma, Non-Small Cell Lung
DrugsQuaratusugene ozeplasmid·Tagrisso·Osimertinib
Genprex, Inc.
Phase 1/2
158
California, Colorado, Illinois, Kentucky, Maryland, New Jersey, Ohio, Texas
2021-09-03
Recruiting
Freedom-1 Study for Chronic Knee Pain
NCT03877653Osteoarthritic Knee Pain
Curonix LLC
Not applicable
100
California, Colorado, Florida, Georgia, Nevada, Ohio, Texas
2021-09-01
Active, closed
Study to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults.
NCT05035212Lower Respiratory Tract Illness
DrugRSVpreF
Pfizer
Phase 3
38,861
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Idaho
2021-08-31
Active, closed
A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
NCT04961996Early Breast Cancer
DrugGiredestrant
Hoffmann-La Roche
Phase 3
4,170
Alabama, California, Colorado, Connecticut, Florida, Illinois, Kansas, Kentucky
2021-08-27
Active, closed
A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)
NCT05026866Alzheimer Disease
DrugDonanemab
Eli Lilly and Company
Phase 3
2,996
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Idaho
2021-08-27
Active, closed
NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers
NCT05020678Lymphoma, Non-Hodgkin, B-cell Acute Lymphoblastic Leukemia, Large B-cell Lymphoma, Mantle Cell Lymphoma
DrugNKX019
Nkarta, Inc.
Phase 1
150
Colorado, Ohio
2021-08-20
Active, closed
A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
NCT04849728NASH - Nonalcoholic Steatohepatitis
Inventiva Pharma
Phase 3
1,000
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia
2021-08-19
Active, closed
Evaluate the Safety and Effectiveness of iSTAR Medical's MINIject™ Implant for Lowering Intraocular Pressure (IOP) in Subjects With Primary Open-angle Glaucoma.
NCT05024695Glaucoma
iSTAR Medical
Not applicable
975
Arizona, Arkansas, California, Colorado, Florida, Idaho, Illinois, Kansas
2021-08-19
By invitation
Selatogrel Outcome Study in Suspected Acute Myocardial Infarction
NCT04957719Acute Myocardial Infarction
Viatris Innovation GmbH
Phase 3
25,000
Alabama, Arizona, California, Colorado, Delaware, District of Columbia, Florida, Georgia
2021-08-14
Recruiting
Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067
NCT04787042Cancer, Solid Tumor, Melanoma, Renal Cell Carcinoma
DrugsObinutuzumab·Keytruda·Pembrolizumab
Simcha IL-18, Inc.
Phase 1/2
316
Arizona, Colorado, Connecticut, Florida, Massachusetts, New York
2021-08-06
Active, closed
US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair
NCT04852783Aneurysm, Intracranial
Cerus Endovascular, Inc.
Phase 4
250
Colorado, Florida, Illinois, Kansas, Massachusetts, New York, North Carolina, Pennsylvania
2021-08-06
Recruiting
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
NCT04913285Solid Tumor, Adult, Non-small Cell Lung Cancer, Melanoma
Pierre Fabre Medicament
Phase 1
400
California, Colorado, Florida, Minnesota, New Jersey, New York, Ohio, Tennessee
2021-08-04
Active, closed
Study to Evaluate the Pharmacokinetics, Efficacy, Tolerability, and Safety of Subcutaneous Human Immunoglobulin (Newnorm) in Patients With Primary Immunodeficiency Diseases
NCT04640142Primary Immune Deficiency
Octapharma
Phase 3
50
California, Colorado, Florida, Illinois, Kansas, Kentucky, Maryland, Missouri
2021-08-04
Recruiting
Zimmer Biomet Shoulder Arthroplasty PMCF
NCT04984291Shoulder Fractures, Shoulder Arthritis, Shoulder Osteoarthritis, Shoulder Deformity
Zimmer Biomet
Not applicable
584
California, Colorado, Illinois, Kentucky, Michigan, Minnesota, Mississippi, Missouri
2021-07-28
Recruiting
Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
NCT04817618C3G
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
98
Colorado, Florida, Georgia, Indiana, Iowa, Maryland, Massachusetts, New Jersey
2021-07-28
By invitation
A Study to Evaluate the Safety and Tolerability of Dapirolizumab Pegol in Study Participants With Systemic Lupus Erythematosus
NCT04976322Systemic Lupus Erythematosus
UCB Biopharma SRL
Phase 3
760
Alabama, Arizona, California, Colorado, Florida, Georgia, Idaho, Illinois
2021-07-27
Recruiting
A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma
NCT04910568Multiple Myeloma
DrugsCevostamab·Pomalidomide·Tocilizumab·Daratumumab
Genentech, Inc.
Phase 1
186
California, Colorado, Georgia, Michigan, Missouri
2021-07-26
Active, closed
M6-C Artificial Cervical Disc Two-Level IDE Pivotal Study
NCT04982835Cervical Disc Degenerative Disorder
Orthofix Inc.
Not applicable
156
Arizona, California, Colorado, Florida, Georgia, Idaho, Illinois, Massachusetts
2021-07-26
Active, closed
ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk
NCT05064553Hepatocellular Carcinoma, Hepatocellular Cancer, Hepatitis B, Cirrhosis
Exact Sciences Corporation
Observational
2,990
Arizona, California, Colorado, District of Columbia, Florida, Illinois, Indiana, Iowa
2021-07-26
Recruiting
A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis
NCT04951622Myasthenia Gravis
DrugNipocalimab
Janssen Research & Development, LLC
Phase 3
199
Arizona, California, Colorado, Connecticut, Florida, Georgia, Kansas, Massachusetts
2021-07-15
Active, closed
A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease-modifying Anti-rheumatic Drugs
NCT04908202Psoriatic Arthritis
DrugDeucravacitinib
Bristol-Myers Squibb
Phase 3
670
Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois
2021-07-13
Active, closed
A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
NCT04951219Non-Alcoholic Fatty Liver Disease
DrugResmetirom
Madrigal Pharmaceuticals, Inc.
Phase 3
810
Alabama, Arizona, Arkansas, California, Colorado, Florida, Georgia, Hawaii
2021-07-09
Active, closed
G7 Acetabular System With Vivacit-E or Longevity Liner PMCF Study
NCT04754087Total Hip Arthroplasty, Degenerative Joint Disease of Hip, Avascular Necrosis of Hip, Rheumatoid Arthritis of Hip
Zimmer Biomet
Not applicable
300
Colorado, Indiana, North Carolina, Oregon, Utah
2021-07-07
Active, closed
Ovarian Suppression Evaluating Subcutaneous Leuprolide Acetate in Breast Cancer
NCT04906395Breast Cancer
DrugsTOL2506·Tamoxifen·Exemestane·Anastrozole
Tolmar Inc.
Phase 3
250
California, Colorado, Illinois, Kentucky, Maryland, Nebraska, New York, Ohio
2021-07-01
Active, closed
Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)
NCT04964934ER-Positive HER2-Negative Breast Cancer
DrugsCamizestrant·Anastrozole·Abemaciclib·Ribociclib
AstraZeneca
Phase 3
315
Arizona, Arkansas, California, Colorado, Florida, Georgia, Illinois, Indiana
2021-06-30
Recruiting
Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors
NCT04900818Solid Tumor, Advanced Cancer, Metastatic Cancer, Gastric Cancer
DrugGivastomig
I-Mab Biopharma US Limited
Phase 1
330
California, Colorado, Indiana, Massachusetts, New Jersey, New York, North Carolina, Tennessee
2021-06-29
Active, closed
Pre-Exposure Prophylaxis Study of Lenacapavir in Cisgender Men, Transgender Women, Transgender Men, and Gender Nonbinary People at Risk for HIV Infection
NCT04925752Pre-Exposure Prophylaxis of HIV Infection
DrugsF/TAF·Descovy·F/TDF·Lenacapavir
Gilead Sciences
Phase 3
3,292
Alabama, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2021-06-28
Active, closed
Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease
NCT04915755Neoplasms, Breast
DrugNiraparib
GlaxoSmithKline
Phase 3
40
California, Colorado, Illinois, Michigan, New Mexico, New York, North Dakota, Pennsylvania
2021-06-28
Active, closed
Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial.
NCT04925024Hypoplastic Left Heart Syndrome
Longeveron Inc.
Phase 2
40
California, Colorado, Georgia, Illinois, Massachusetts, Nebraska, Ohio, Pennsylvania
2021-06-25
Active, closed
Global Safety and Efficacy Registration Study of Crinecerfont in Pediatric Participants With Classic Congenital Adrenal Hyperplasia (CAHtalyst Pediatric Study)
NCT04806451Congenital Adrenal Hyperplasia
DrugCrinecerfont
Neurocrine Biosciences
Phase 3
103
Alabama, California, Colorado, Connecticut, District of Columbia, Georgia, Indiana, Massachusetts
2021-06-25
Active, closed
A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy
NCT04629248Primary Membranous Nephropathy
DrugsDiphenhydramine·Acetaminophen·Tacrolimus·Methylprednisolone
Hoffmann-La Roche
Phase 3
142
California, Colorado, Florida, Iowa, Michigan, Minnesota, New York, Texas
2021-06-25
Active, closed
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
NCT04793958Advanced Colorectal Cancer, Metastatic Colorectal Cancer
DrugsAdagrasib·MFOLFOX6·Erbitux·Folfiri
Mirati Therapeutics Inc.
Phase 3
461
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia
2021-06-24
By invitation
Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting
NCT04451044Coronary Artery Disease, Ischemic Heart Disease
Philips Clinical & Medical Affairs Global
Not applicable
3,212
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2021-06-17
Active, closed
177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer
NCT04689828Prostatic Neoplasms
DrugsARDT·Illuccix·Lu-PSMA
Novartis Pharmaceuticals
Phase 3
469
Colorado, Florida, Louisiana, Massachusetts, Missouri, Nebraska, New York, North Carolina
2021-06-15
Recruiting
Persona Revision Knee System Outcomes
NCT04821154Arthroplasty Complications, Infection, Knee Disease, Knee Osteoarthritis
Zimmer Biomet
Observational
380
Arkansas, California, Colorado, Indiana, Kentucky, Michigan, Minnesota, Missouri
2021-06-14
Active, closed
Assessing Outcomes With Microprocessor Knee Utilization in a K2 Population
NCT04784429Lower Limb Amputation Above Knee (Injury), Congenital Amputation of Lower Limb, Lower Limb Amputation Knee
Otto Bock Healthcare Products GmbH
Not applicable
107
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2021-06-11
Recruiting
Device Global Registry for the IlluminOss Bone Stabilization System
NCT05206981Traumatic Fracture, Pathological Fracture
IlluminOss Medical, Inc.
Observational
300
Alabama, California, Colorado, Florida, Indiana, New York, North Carolina, Pennsylvania
2021-06-11
Active, closed
An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With Standard of Care (SoC), Versus SoC Alone, in Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC)
NCT04720157Prostatic Neoplasms
DrugsARDT·Illuccix·Lu-PSMA
Novartis Pharmaceuticals
Phase 3
1,140
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Hawaii
2021-06-09
Active, closed
Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus
NCT04877691Systemic Lupus Erythematosus
DrugAnifrolumab
AstraZeneca
Phase 3
367
Alabama, Arizona, California, Colorado, Florida, Idaho, Michigan, New Jersey
2021-06-08
Active, closed
Valemetostat Tosylate (DS-3201b), an Enhancer of Zeste Homolog (EZH) 1/2 Dual Inhibitor, for Relapsed/Refractory Peripheral T-Cell Lymphoma (VALENTINE-PTCL01)
NCT04703192Relapsed/Refractory Peripheral T-Cell Lymphoma, Adult T Cell Leukemia/Lymphoma
DrugValemetostat Tosylate
Daiichi Sankyo
Phase 2
155
California, Colorado, Georgia, Illinois, Massachusetts, Minnesota, Missouri, New Jersey
2021-06-03
Active, closed
Persona Ti-Nidium Post-Market Clinical Follow-up
NCT04817969Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
Zimmer Biomet
Not applicable
240
Colorado, Maryland, Mississippi, New Mexico, North Carolina, Pennsylvania, South Dakota
2021-06-01
Active, closed
A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus
NCT04895241Lupus Erythematosus, Systemic
DrugLitifilimab
Biogen
Phase 3
548
Alabama, California, Colorado, District of Columbia, Florida, Georgia, Louisiana, Michigan
2021-05-25
Active, closed
3Spine Lumbar Fusion Real World Evidence Study
NCT04823858Lumbar Spine Degeneration
3Spine
Observational
176
California, Colorado, Florida, Kentucky, Louisiana, Minnesota, New York, North Carolina
2021-05-25
Recruiting
DALY II USA/ MB-CART2019.1 for DLBCL
NCT04792489Refractory Diffuse Large B Cell Lymphoma (DLBCL), Relapsed Diffuse Large B Cell Lymphoma, High Grade B-cell Lymphoma (HGBCL), Primary Mediastinal B-cell Lymphoma (PMBCL)
DrugsZamtocabtagene autoleucel·Bendamustine·Fludarabine·Cyclophosphamide
Miltenyi Biomedicine GmbH
Phase 2
315
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2021-05-25
Active, closed
Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)
NCT04544293Autoimmune Pulmonary Alveolar Proteinosis
DrugMolgramostim
Savara Inc.
Phase 3
164
Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois, Maryland
2021-05-19
Active, closed
A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme
NCT04762069Glioblastoma Multiforme, Adult
DrugsCCNU·Lomustine
CNS Pharmaceuticals, Inc.
Phase 2
252
Arkansas, California, Colorado, Florida, Georgia, Illinois, Kentucky, Louisiana
2021-05-18
Recruiting
GORE® ENFORM Biomaterial Product Study
NCT04718168Hernia, Ventral, Hernia, Hiatal, Hernia, Diaphragmatic, Incisional Hernia
W.L.Gore & Associates
Not applicable
245
California, Colorado, Florida, Illinois, Kentucky, North Carolina, South Carolina, Texas
2021-05-17
Active, closed
A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-mutant Advanced Melanoma.
NCT04835805Melanoma
DrugsBelvarafenib·Cobimetinib·Nivolumab
Genentech, Inc.
Phase 1
65
California, Colorado, Iowa, Maryland, Missouri, New York, Tennessee
2021-05-13
Recruiting
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
NCT07218029Pulmonary Arterial Hypertension
DrugSotatercept
Merck Sharp & Dohme LLC
Phase 3
815
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Kansas, Kentucky
2021-05-12
Active, closed
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
NCT04824092Diffuse Large B-cell Lymphoma
DrugsTafasitamab·Vincristine·Doxorubicin·Prednisone
Incyte Corporation
Phase 3
899
Alabama, California, Colorado, Florida, Hawaii, Kansas, Kentucky, Maryland
2021-05-11
Active, closed
A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR)
NCT04647253In-Stent Restenosis
Boston Scientific Corporation
Phase 3
600
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Kansas
2021-05-11
Active, closed
Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)
NCT04862663Locally Advanced (Inoperable) or Metastatic Breast Cancer
DrugsCapivasertib·Abemaciclib·Ribociclib·Palbociclib
AstraZeneca
Phase 3
893
Arizona, California, Colorado, Connecticut, Delaware, Kentucky, Maryland, Massachusetts
2021-05-10
Active, closed
A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease
NCT04777331Parkinsons Disease
DrugPrasinezumab
Hoffmann-La Roche
Phase 2
586
Alabama, Arizona, California, Colorado, Connecticut, Florida, Illinois, Kansas
2021-05-05
Recruiting
A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies
NCT04830137Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Waldenstrom Macroglobulinemia (WM), Mantle Cell Lymphoma (MCL)
Nurix Therapeutics, Inc.
Phase 1
248
California, Colorado, Florida, Illinois, Maryland, New York, Ohio, Tennessee
2021-05-05
Active, closed
A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY)
NCT04853576Sickle Cell Disease, Hemoglobinopathies
Editas Medicine, Inc.
Phase 1/2
45
California, Colorado, Connecticut, Florida, Georgia, Illinois, Mississippi, New Jersey
2021-05-04
Recruiting
Ventral or Inguinal Hernia, Robotically Repaired With OviTex Mesh
NCT04779918Hernia, Ventral, Hernia, Inguinal
Tela Bio Inc
Not applicable
160
Alabama, Colorado, Florida, Kansas, Kentucky, Michigan, New York, Texas
2021-04-29
Recruiting
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
NCT04743141Acute Treatment of Migraine
DrugRimegepant
Pfizer
Phase 3
600
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2021-04-28
Active, closed
Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma
NCT04756726Multiple Myeloma, Lymphoma, Non-Hodgkin's
DrugsCemsidomide·Dexamethasone
C4 Therapeutics, Inc.
Phase 1
224
Arizona, California, Colorado, Florida, Georgia, Massachusetts, Minnesota, Missouri
2021-04-27
Active, closed
Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)
NCT04784715Breast Cancer; HER2-positive; Metastatic
DrugsPertuzumab·Trastuzumab deruxtecan·Trastuzumab
AstraZeneca
Phase 3
1,157
Arizona, Arkansas, California, Colorado, Florida, Georgia, Kentucky, Maryland
2021-04-26
Recruiting
LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve
NCT04752722Superficial Bladder Cancer, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ, Non-muscle Invasive Bladder Cancer
DrugPhase 2
enGene, Inc.
Phase 1/2
350
Alabama, Arizona, Arkansas, California, Colorado, District of Columbia, Florida, Georgia
2021-04-22
Active, closed
Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)
NCT04700124Bladder Cancer
DrugsEnfortumab Vedotin·Keytruda·Gemcitabine·Cisplatin
Merck Sharp & Dohme LLC
Phase 3
808
Arizona, California, Colorado, Florida, Indiana, Iowa, Kentucky, New York
2021-04-21
Active, closed
Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum
NCT04589650PIK3CA-related Overgrowth Spectrum (PROS)
DrugAlpelisib
Novartis Pharmaceuticals
Phase 2
206
California, Colorado, Missouri, New York, North Carolina, Ohio, Pennsylvania, Texas
2021-04-19
Active, closed
Breast Cancer Index (BCI) Registry
NCT04875351Breast Cancer
Biotheranostics, Inc.
Observational
3,465
Alabama, Arizona, California, Colorado, Florida, Illinois, Maryland, New York
2021-04-14
Active, closed
COMPASSION S3 Post-Approval Study
NCT04860765Complex Congenital Heart Defect, Dysfunctional RVOT Conduit, Pulmonary Valve Insufficiency, Pulmonary Valve Degeneration
Edwards Lifesciences
Observational
150
Alabama, California, Colorado, Illinois, Massachusetts, Minnesota, Missouri, New Jersey
2021-04-13
Active, closed
Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function
NCT04763200Left Ventricular Dysfunction, Coronary Artery Disease
Abiomed Inc.
Not applicable
1,252
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2021-04-13
Active, closed
Eversense® Non-adjunctive Use Post Approval Study
NCT04836546Diabetes
Senseonics, Inc.
Not applicable
925
California, Colorado, Connecticut, Florida, Georgia, Idaho, Illinois, Louisiana
2021-04-13
Active, closed
TRISCEND II Pivotal Trial
NCT04482062Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases
Edwards Lifesciences
Not applicable
864
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas
2021-04-09
Active, closed
Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)
NCT04662255Lymphoma, Mantle-Cell
DrugsPirtobrutinib·Ibrutinib·Acalabrutinib·Zanubrutinib
Loxo Oncology, Inc.
Phase 3
500
Alaska, Arizona, California, Colorado, Florida, Kentucky, Louisiana, Maryland
2021-04-08
Recruiting
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
NCT04728893Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia
DrugNemtabrutinib
Merck Sharp & Dohme LLC
Phase 2
490
Arkansas, California, Colorado, Kentucky, Minnesota, New Jersey, North Dakota, Texas
2021-04-05
Active, closed
SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial
NCT04722250Symptomatic Aortic Stenosis, Aortic Valve Stenosis, Aortic Valve Replacement
Medtronic Cardiovascular
Not applicable
1,103
California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois, Indiana
2021-04-02
Active, closed
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
NCT04822181Non-alcoholic Steatohepatitis
DrugSemaglutide
Novo Nordisk A/S
Phase 3
1,205
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia
2021-04-01
Recruiting
This is a Study to Evaluate the Safety and Tolerability of ABL503, and to Determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of ABL503 in Subjects with Any Progressive Locally Advanced or Metastatic Solid Tumors
NCT04762641Advanced Solid Tumor
ABL Bio, Inc.
Phase 1
100
California, Colorado, Texas
2021-04-01
Active, closed
Clinical Assessment of Pharmacokinetics, Efficacy, and Safety of 10% IVIg in Pediatric PID Patients (KIDCARES10)
NCT04944979Primary Immunodeficiency Disease
DrugKedrion IVIG
Kedrion S.p.A.
Phase 3
30
California, Colorado, Florida, Louisiana, North Carolina, Ohio, Oklahoma
2021-03-31
Active, closed
A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis
NCT04562870Myelofibrosis
DrugSelinexor
Karyopharm Therapeutics Inc
Phase 2
112
California, Colorado, Illinois, Texas
2021-03-17
Active, closed
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
NCT04586010Relapsing Multiple Sclerosis
DrugsFenebrutinib·Teriflunomide
Hoffmann-La Roche
Phase 3
746
Alabama, Arizona, California, Colorado, Florida, Illinois, Indiana, Louisiana
2021-03-17
Active, closed
Atrasentan in Patients With Proteinuric Glomerular Diseases
NCT04573920IgA Nephropathy, Focal Segmental Glomerulosclerosis, Alport Syndrome, Diabetic Kidney Disease
DrugAtrasentan
Novartis Pharmaceuticals
Phase 2
103
California, Colorado, Louisiana, Massachusetts, Minnesota, Nevada, North Carolina, Texas
2021-03-15
Active, closed
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
NCT04591392Heart Septal Defect, Heart Septal Defects, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities
atHeart Medical
Not applicable
250
Alabama, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2021-03-12
Active, closed
A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma
NCT04722146Multiple Myeloma
DrugsNirogacestat·Teclistamab·Pomalidomide·Bortezomib
Janssen Research & Development, LLC
Phase 1
140
Alabama, California, Colorado, Georgia, Indiana, Missouri, New Jersey, New York
2021-03-12
Active, closed
Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis
NCT04562389Myelofibrosis
DrugsSelinexor·Ruxolitinib
Karyopharm Therapeutics Inc
Phase 3
353
Alabama, California, Colorado, Connecticut, District of Columbia, Kentucky, Maryland, Michigan
2021-03-11
Active, closed
Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT04666038Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
DrugsIdelalisib·Truxima·Pirtobrutinib·Bendamustine
Loxo Oncology, Inc.
Phase 3
238
Alabama, Arizona, California, Colorado, Delaware, Florida, Georgia, Illinois
2021-03-09
Active, closed
SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity
NCT04775082Obesity
DrugLiraglutide
Novo Nordisk A/S
Phase 3
78
Arizona, Colorado, Idaho, Louisiana, Maryland, Minnesota, New York, Ohio
2021-03-04
Recruiting
A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
NCT04678648Advanced Malignant Solid Neoplasm, RAS Mutation, Lung Cancer, Colon Cancer
Drugs[²¹²Pb]Pb-ADVC001·Expansion
RasCal Therapeutics, Inc.
Phase 1
134
California, Colorado, Tennessee
2021-03-03
Active, closed
A Clinical Trial Comparing the BAGUERA C to the Marketed Mobi-C® for the Treatment of Cervical Disc Disease at 2 Contiguous Levels
NCT04564885Cervical Disc Disease
Spineart USA
Not applicable
300
Arizona, California, Colorado, Connecticut, District of Columbia, Georgia, Illinois, Indiana
2021-03-02
Active, closed
Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment
NCT04647526Metastatic Castration-Resistant Prostate Cancer
DrugsAbiraterone·Enzalutamide
POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company
Phase 3
455
Arizona, California, Colorado, Florida, Iowa, Kentucky, Louisiana, Maryland
2021-02-25
Active, closed
Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms
NCT04279847Myelofibrosis, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasm Overlap Syndrome, Myeloproliferative Neoplasm
DrugRuxolitinib
Incyte Corporation
Phase 1
140
Alabama, Colorado, Florida, Georgia, Iowa, Missouri, New Jersey, New York
2021-02-23
Active, closed
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
NCT04685135Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
DrugsAdagrasib·Taxotere·Docetaxel
Mirati Therapeutics Inc.
Phase 3
453
California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas, Kentucky
2021-02-23
Recruiting
Qudexy XR for the Prevention of Migraine in Children 6 to 11 Years Old
NCT04748601Migraine Disorders
Upsher-Smith Laboratories
Phase 4
132
Alabama, California, Colorado, Connecticut, Florida, Michigan, Mississippi, Missouri
2021-02-19
Recruiting
PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches
NCT04545502Aneurysm, Dissection, Aortic Root Aneurysm, Aortic Root Dissection
Vascutek Ltd.
Observational
2,000
Colorado, Florida, Indiana, North Carolina, Ohio, Pennsylvania, Virginia
2021-02-17
Active, closed
Paresthesia-Free Fast-Acting Subperception (FAST) Study
NCT04618471Chronic Pain
Boston Scientific Corporation
Not applicable
177
California, Colorado, Florida, Illinois, Indiana, Louisiana, New York, North Carolina
2021-02-10
Active, closed
DNA-guided Second Line Adjuvant Therapy for High Residual Risk, Estrogen Receptor Positive, HER-2 Negative Breast Cancer (DARE)
NCT04567420Breast Cancer
DrugsPalbociclib·Fulvestrant
Criterium, Inc.
Phase 2
70
Arizona, California, Colorado, Connecticut, Georgia, Louisiana, Nebraska, New Mexico
2021-02-09
Active, closed
INFINITY™ With ADAPTIS™ Technology Study
NCT04594993Arthritis, Rheumatoid
Stryker Trauma and Extremities
Observational
200
Arizona, California, Colorado, Florida, Illinois, New York, Oregon, South Carolina
2021-02-09
Active, closed
Galinpepimut-S Versus Investigator's Choice of Best Available Therapy for Maintenance in AML CR2/CRp2
NCT04229979Acute Myeloid Leukemia
DrugsGm-Csf·Sargramostim·Ara-C·Decitabine
Sellas Life Sciences Group
Phase 3
127
Alabama, California, Colorado, Florida, Georgia, Illinois, Louisiana, New York
2021-02-08
Active, closed
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Emicizumab in Participants From Birth to 12 Months of Age With Hemophilia A Without Inhibitors
NCT04431726Severe Hemophilia A
DrugEmicizumab
Hoffmann-La Roche
Phase 3
55
Arizona, California, Colorado, Louisiana, Michigan, Washington
2021-02-04
Recruiting
Doravirine (DOR) in Human Immunodeficiency Virus (HIV)-Infected Children Aged 4 Weeks to <12 Years and <45 kg (MK-1439-066)
NCT04375800Human Immunodeficiency Virus (HIV) Infection
Drugs2 NRTIs·DOR/3TC/TDF·Doravirine
Merck Sharp & Dohme LLC
Phase 2
84
Colorado, Georgia
2021-02-03
Active, closed
HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer
NCT04619004Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor
DrugPatritumab deruxtecan
Daiichi Sankyo
Phase 2
277
Arizona, California, Colorado, Florida, Georgia, Illinois, Maryland, Massachusetts
2021-02-02
Active, closed
A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
NCT04711252ER-Positive HER2-Negative Breast Cancer
DrugsCamizestrant·Anastrozole·Palbociclib
AstraZeneca
Phase 3
1,371
Alabama, Arkansas, California, Colorado, Florida, Indiana, Louisiana, Maryland
2021-01-28
Recruiting
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
NCT04657068Advanced Cancer, Metastatic Cancer, Ovarian Cancer, Primary Peritoneal Cancer
DrugsIrinotecan·Gemcitabine
Artios Pharma Ltd
Phase 1/2
542
Alabama, Arizona, Arkansas, California, Colorado, Florida, Illinois, Indiana
2021-01-27
Recruiting
Adjustable Continence Therapy (ACT) for the Treatment of Female SUI
NCT04248283Urinary Incontinence, Urinary Incontinence,Stress
Uromedica
Not applicable
167
Colorado, Idaho, Missouri, Nebraska, Pennsylvania
2021-01-26
Active, closed
Post-Approval Study of the TREO Abdominal Stent-Graft System
NCT04697784Abdominal Aortic Aneurysm
Bolton Medical
Not applicable
338
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Iowa
2021-01-20
Active, closed
An Open-Label Extension Study of STK-001 for Patients With Dravet Syndrome
NCT04740476Dravet Syndrome
DrugZorevunersen
Stoke Therapeutics, Inc
Phase 2
60
California, Colorado, District of Columbia, Florida, Illinois, Iowa, Massachusetts, Michigan
2021-01-20
Recruiting
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
NCT04649242Pediatric Migraine
Pfizer
Phase 3
2,100
Alabama, Arizona, California, Colorado, Connecticut, Delaware, District of Columbia, Florida
2021-01-15
Active, closed
Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis
NCT04539964Rheumatoid Arthritis
DrugConventional Synthetic DMARD
SetPoint Medical Corporation
Phase 3
243
Arizona, California, Colorado, Connecticut, Delaware, Florida, Georgia, Illinois
2021-01-11
Active, closed
Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations
NCT04579380Uterine Neoplasms, Uterine Cervical Neoplasms, Biliary Tract Neoplasms, Urologic Neoplasms
DrugsTucatinib·Herceptin·Fulvestrant·Trastuzumab
Seagen, a wholly owned subsidiary of Pfizer
Phase 2
217
Arizona, California, Colorado, Florida, Minnesota, Missouri, Nebraska, New York
2021-01-11
Active, closed
Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
NCT04634877Endometrial Neoplasms
DrugsDocetaxel·Keytruda·Paclitaxel·Cisplatin
Merck Sharp & Dohme LLC
Phase 3
990
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2021-01-10
Active, closed
MYLUNG Consortium Study Protocol 2
NCT05644808Carcinoma, Non-Small-Cell Lung
US Oncology Research
Observational
1,002
Alabama, Colorado, Florida, Illinois, Maryland, Minnesota, New York, Ohio
2020-12-29
Active, closed
Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD
NCT04704921AMD, nAMD, Wet Age-related Macular Degeneration, wAMD
DrugsLucentis·Ranibizumab
AbbVie
Phase 2/3
671
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Hawaii
2020-12-29
Recruiting
Secukinumab Open Label Roll-over Extension Protocol
NCT04638647Autoimmunity, Inflammation
DrugSecukinumab
Novartis Pharmaceuticals
Phase 4
1,000
California, Colorado, Florida, Illinois, Indiana, Maryland, Michigan, Nebraska
2020-12-22
Active, closed
A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors
NCT04707248Renal Cell Carcinoma, Ovarian Tumor
DrugR-DXd
Daiichi Sankyo
Phase 1
179
Arizona, Colorado, Florida, Oklahoma, Tennessee
2020-12-22
Active, closed
Study of Immune Globulin Intravenous (Human) GC5107 in Pediatric Subjects With Primary Humoral Immunodeficiency
NCT04565015Primary Immune Deficiency
GC Biopharma Corp
Phase 3
24
Colorado, Texas, Virginia
2020-12-21
Active, closed
A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers
NCT04626635Advanced Solid Tumors
DrugsMarlotamig·Trifluridine/Tipiracil·Cemiplimab·Bevacizumab
Regeneron Pharmaceuticals
Phase 1/2
548
California, Colorado, Florida, Illinois, Iowa, Michigan, New Jersey, New York
2020-12-21
Active, closed
Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules
NCT04171492Nodule Solitary Pulmonary, Non-small Cell Carcinoma
Biodesix, Inc.
Observational
2,000
Colorado, Connecticut, District of Columbia, Indiana, Maryland, Michigan, Minnesota, Missouri
2020-12-18
Active, closed
A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy
NCT04640623Urinary Bladder Neoplasms
DrugsTAR-200·Cetrelimab
Janssen Research & Development, LLC
Phase 2
220
Arizona, California, Colorado, Illinois, Indiana, Kansas, Michigan, New York
2020-12-18
Active, closed
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
NCT04663308Primary Sclerosing Cholangitis
DrugVolixibat
Mirum Pharmaceuticals, Inc.
Phase 2
182
California, Colorado, District of Columbia, Florida, Massachusetts, Michigan, Minnesota, Mississippi
2020-12-18
Active, closed
Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia
NCT04490915Congenital Adrenal Hyperplasia
DrugCrinecerfont
Neurocrine Biosciences
Phase 3
182
California, Colorado, Georgia, Indiana, Maryland, Massachusetts, Michigan, Minnesota
2020-12-16
Active, closed
A Study of the Combination of Talquetamab and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma
NCT04586426Multiple Myeloma
DrugsTalquetamab·Teclistamab
Janssen Research & Development, LLC
Phase 1/2
228
Alabama, Arkansas, Colorado, Georgia, Minnesota, Missouri, New York, North Carolina
2020-12-15
Active, closed
Study to Evaluate Rilzabrutinib in Adults and Adolescents With Persistent or Chronic Immune Thrombocytopenia (ITP)
NCT04562766Immune Thrombocytopenia
DrugRilzabrutinib
Principia Biopharma, a Sanofi Company
Phase 3
232
California, Colorado, Florida, Georgia, Illinois, Kentucky, Massachusetts, New York
2020-12-14
Active, closed
Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]
NCT04645212Wet Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration
Adverum Biotechnologies, Inc.
Observational
23
California, Colorado, Florida, Nevada, Pennsylvania, Tennessee, Texas
2020-12-14
Active, closed
A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001)
NCT04471727Small-Cell Lung Cancer, Neuroendocrine Carcinoma
DrugsGocatamig·Ifinatamab Deruxtecan·Atezolizumab
Harpoon Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 1/2
232
California, Colorado, Massachusetts, Michigan, New York, Ohio, Oregon, Tennessee
2020-12-14
Active, closed
Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
NCT04652882Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders
DrugTasimelteon
Vanda Pharmaceuticals
Phase 3
70
California, Colorado, Massachusetts, Missouri, New York, Ohio, South Carolina, Texas
2020-12-09
Active, closed
A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder
NCT04658862Urinary Bladder Neoplasms
DrugsTAR-200·Cetrelimab·Gemcitabine·Cisplatin
Janssen Research & Development, LLC
Phase 3
518
California, Colorado, Florida, Georgia, Illinois, Michigan, Nebraska, New Jersey
2020-12-07
Active, closed
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
NCT04548999Multiple Sclerosis
DrugsOcrelizumab·Methylprednisolone
Hoffmann-La Roche
Phase 3
769
Alabama, Arizona, California, Colorado, Florida, Kentucky, Maryland, Massachusetts
2020-12-03
Recruiting
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
NCT04613596Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer
DrugsAdagrasib·Pembrolizumab
Mirati Therapeutics Inc.
Phase 2/3
626
Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida, Georgia
2020-12-02
Active, closed
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)
NCT04544436Multiple Sclerosis
DrugsOcrelizumab·Methylprednisolone
Hoffmann-La Roche
Phase 3
864
Alabama, Arizona, California, Colorado, Florida, Indiana, Kansas, Louisiana
2020-11-26
Active, closed
A Study of Galcanezumab (LY2951742) in Participants 12 to 17 Years of Age With Chronic Migraine
NCT04616326Chronic Migraine
DrugGalcanezumab
Eli Lilly and Company
Phase 3
312
Alabama, Arizona, California, Colorado, Florida, Idaho, Illinois, Kansas
2020-11-25
Active, closed
The ENCIRCLE Trial
NCT04153292Mitral Regurgitation, Mitral Valve Insufficiency
Edwards Lifesciences
Not applicable
786
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Kansas
2020-11-12
Active, closed
A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer
NCT04557059Prostatic Neoplasms
DrugsLhrha·Apalutamide
Janssen Pharmaceutica N.V., Belgium
Phase 3
691
Arizona, Arkansas, Colorado, Florida, Indiana, Michigan, New York, Ohio
2020-11-12
Recruiting
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
NCT04302025Non-small Cell Lung Cancer
DrugsCobimetinib·Pralsetinib·Divarasib·SBRT
Genentech, Inc.
Phase 2
99
California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Massachusetts, Michigan
2020-11-06
Active, closed
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)
NCT04524871Advanced Liver Cancers
DrugsADG126·Tobemstomig·Tiragolumab·Tocilizumab
Hoffmann-La Roche
Phase 1/2
518
California, Colorado, Connecticut, District of Columbia, Kentucky, Oregon, Tennessee, Texas
2020-11-01
Active, closed
The Synergy Disc To Anterior Cervical Discectomy and Fusion
NCT04469231Cervical Degenerative Disc Disease
Synergy Spine Solutions
Not applicable
175
Arizona, California, Colorado, Florida, Indiana, Michigan, New York, North Carolina
2020-10-30
Recruiting
The Tether™ - Vertebral Body Tethering System Post Approval Study
NCT04505579Scoliosis Idiopathic
ZimVie
Observational
200
California, Colorado, Florida, Georgia, Louisiana, Minnesota, Missouri, New York
2020-10-29
Recruiting
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
NCT04585750Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor
DrugsRezatapopt·Keytruda·Pembrolizumab
PMV Pharmaceuticals, Inc
Phase 1/2
300
California, Colorado, Connecticut, Delaware, Florida, Massachusetts, Michigan, New York
2020-10-29
Active, closed
Study of Cretostimogene Given in Patients With Non-Muscle Invasive Bladder Cancer ,Unresponsive to Bacillus-Calmette-Guerin
NCT04452591Non Muscle Invasive Bladder Cancer, High-grade Ta/ T1 Papillary Disease Bladder Cancer
DrugCretostimogene Grenadenorepvec
CG Oncology, Inc.
Phase 3
190
Alabama, Arizona, Arkansas, California, Colorado, District of Columbia, Florida, Georgia
2020-10-27
Active, closed
Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)
NCT04598893Diabetes Mellitus, Type 1
DrugTeplizumab
Provention Bio, a Sanofi Company
Observational
188
California, Colorado, Florida, Georgia, Idaho, Indiana, Iowa, Maryland
2020-10-26
Active, closed
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis
NCT04544449Multiple Sclerosis, Primary Progressive
DrugsFenebrutinib·Ocrelizumab
Hoffmann-La Roche
Phase 3
985
Alabama, California, Colorado, Connecticut, District of Columbia, Florida, Indiana, Kansas
2020-10-26
Recruiting
A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer
NCT04516447Solid Tumor, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
DrugsAzenosertib·Pegylated liposomal doxorubicin·Gemcitabine·Paclitaxel
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Phase 1
172
Colorado, Massachusetts, Missouri, New York, North Carolina, Rhode Island, Tennessee, Texas
2020-10-26
By invitation
Post Market Clinical Follow-Up Study for PROFEMUR® Preserve Classic Femoral Stem
NCT04147559Joint Diseases
MicroPort Orthopedics Inc.
Observational
150
Arizona, Colorado
2020-10-21
Active, closed
Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer
NCT04464226Cancer
DrugDarolutamide
Bayer
Phase 3
402
Alabama, Arizona, California, Colorado, Florida, Illinois, Kentucky, Maryland
2020-10-20
Recruiting
NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness
NCT04471909Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
Endospan Ltd.
Not applicable
110
Alabama, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2020-10-20
Active, closed
Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC
NCT04446117Metastatic Prostate Cancer, Prostate Adenocarcinoma
DrugsZytiga·Xtandi·Abiraterone·Abiraterone acetate
Exelixis
Phase 3
575
Arizona, California, Colorado, Connecticut, Florida, Georgia, Kansas, Kentucky
2020-10-19
Active, closed
CHAMPION-AF Clinical Trial
NCT04394546Atrial Fibrillation, Stroke, Bleeding
DrugsNon-Vitamin K Anticoagulant·NOAC
Boston Scientific Corporation
Not applicable
3,000
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, District of Columbia
2020-10-15
Active, closed
A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)
NCT04546009Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer
DrugsGiredestrant·Palbociclib·Letrozole
Hoffmann-La Roche
Phase 3
992
California, Colorado, Florida, Hawaii, Maryland, Massachusetts, Missouri, New Jersey
2020-10-09
Active, closed
A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312)
NCT04529772Diffuse Large B-Cell Lymphoma
DrugsAcalabrutinib·Vincristine·Doxorubicin·Prednisone
Acerta Pharma BV
Phase 3
611
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Iowa
2020-10-08
Active, closed
A Study of DSP107 Alone and in Combination with Atezolizumab for Patients with Advanced Solid Tumors
NCT04440735Advanced Solid Tumor, Non Small Cell Lung Cancer, Colorectal Cancer
DrugsDSP107·Atezolizumab
Kahr Medical
Phase 1/2
125
California, Colorado, Florida, Indiana, Kansas, Pennsylvania
2020-10-07
Active, closed
A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
NCT04487080Carcinoma, Non-Small-Cell Lung
DrugsLazertinib·Amivantamab·Osimertinib
Janssen Research & Development, LLC
Phase 3
1,074
Arizona, California, Colorado, Florida, Georgia, Louisiana, Maryland, Michigan
2020-09-30
By invitation
Post Market Clinical Follow-Up Study- EVOLUTION® Revision CCK
NCT04145401Knee Osteoarthritis
MicroPort Orthopedics Inc.
Observational
45
Colorado
2020-09-30
Active, closed
Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)
NCT04526665Primary Biliary Cirrhosis
DrugElafibranor
Ipsen
Phase 3
161
Arizona, California, Colorado, Connecticut, Florida, Georgia, Kansas, Massachusetts
2020-09-24
Active, closed
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC)
NCT04497844Prostatic Neoplasms
DrugsAbiraterone acetate·Prednisone
Janssen Research & Development, LLC
Phase 3
696
Alabama, Arizona, California, Colorado, Connecticut, Florida, Indiana, Louisiana
2020-09-23
Active, closed
NKX101, Intravenous Allogeneic CAR NK Cells, in Adults With AML or MDS
NCT04623944Relapsed/Refractory AML, AML, Adult, MDS, Refractory Myelodysplastic Syndromes
DrugsDecitabine·Fludarabine·Cyclophosphamide
Nkarta, Inc.
Phase 1
61
Colorado, Florida, Georgia, Illinois, Ohio, Tennessee, Texas
2020-09-21
Active, closed
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP, an Autoimmune Disorder That Affects the Peripheral Nerves)
NCT04280718Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
DrugEfgartigimod PH20
argenx
Phase 2
229
Alabama, Arizona, California, Colorado, Florida, Iowa, Kansas, Kentucky
2020-09-18
Active, closed
Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC
NCT04140526Non Small Cell Lung Cancer, Advanced Solid Tumor, Metastatic Melanoma, Metastatic Head and Neck Carcinoma
DrugsGotistobart·Taxotere·Docetaxel·Keytruda
OncoC4, Inc.
Phase 1/2
733
Arkansas, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Kentucky
2020-09-16
Active, closed
Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers
NCT04430738Colorectal Carcinoma, Gastric Adenocarcinoma, GEJ Adenocarcinoma, Esophageal Adenocarcinoma
DrugsTucatinib·Fluorouracil·Leucovorin·Trastuzumab
Seagen, a wholly owned subsidiary of Pfizer
Phase 2
40
Arizona, Colorado, District of Columbia, Missouri, New Mexico, North Carolina, Ohio, Washington
2020-09-15
Recruiting
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
NCT04427384Brain Tumor, Recurrent, Brain Tumor, Brain Tumor, Primary, Brain Tumor - Metastatic
GT Medical Technologies, Inc.
Observational
600
Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Indiana
2020-09-11
Active, closed
Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome
NCT04401748Myelodysplastic Syndrome (MDS)
DrugsVenclexta·Azacitidine·Venetoclax
AbbVie
Phase 3
531
California, Colorado, Connecticut, Delaware, Florida, Idaho, Illinois, Indiana
2020-09-10
Active, closed
Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis
NCT04468984Myelofibrosis (MF)
DrugsNavitoclax·Ruxolitinib
AbbVie
Phase 3
330
Arizona, Arkansas, California, Colorado, Georgia, Illinois, Indiana, Louisiana
2020-08-31
Active, closed
A Study of Intravitreal ILUVIEN® Implant as Baseline Therapy in Patients With Early Diabetic Macular Edema (DME)
NCT04469595Diabetic Macular Edema
DrugsEylea·Aflibercept
Alimera Sciences
Phase 4
300
Arizona, California, Colorado, Florida, Georgia, Illinois, Kansas, Louisiana
2020-08-31
Recruiting
Hydrus® Microstent New Enrollment Post-Approval Study
NCT04553523Primary Open Angle Glaucoma
Alcon Research
Not applicable
545
California, Colorado, Iowa, Kansas, Maryland, Michigan, Minnesota, Missouri
2020-08-25
Active, closed
Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery
NCT04498117Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma
DrugsOregovomab·Paraplatin·Taxol·Paclitaxel
CanariaBio Inc.
Phase 3
615
Arizona, California, Colorado, Connecticut, Florida, Georgia, Hawaii, Indiana
2020-08-25
Active, closed
Cerliponase Alfa Observational Study in the US
NCT04476862Late-Infantile Neuronal Ceroid Lipofuscinosis Type 2
BioMarin Pharmaceutical
Observational
35
Arkansas, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Massachusetts
2020-08-19
Active, closed
LIFE-BTK Randomized Controlled Trial
NCT04227899Critical Limb Ischemia (CLI)
Abbott Medical Devices
Not applicable
261
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois
2020-08-18
Active, closed
Study Of Oral Elagolix Tablets In Combination With Combined Oral Contraceptive Capsules/Tablets To Assess Dysmenorrhea Response In Adult Female Participants With Endometriosis And Associated Moderate To Severe Pain
NCT04333576Endometriosis
DrugCombined contraceptive
AbbVie
Phase 3
800
Alabama, Arizona, Arkansas, California, Colorado, Delaware, District of Columbia, Florida
2020-08-10
Active, closed
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
NCT04221477Lupus Nephritis
DrugsDiphenhydramine·Acetaminophen·Methylprednisolone·Obinutuzumab
Hoffmann-La Roche
Phase 3
271
Alabama, California, Colorado, Connecticut, Florida, Georgia, New York, Ohio
2020-08-10
Active, closed
A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies
NCT04227847Myelodysplastic Syndrome, Acute Myeloid Leukemia
DrugsVenclexta·Azacitidine·Venetoclax
Seagen, a wholly owned subsidiary of Pfizer
Phase 1
170
Alabama, California, Colorado, Kansas, Kentucky, Massachusetts, Michigan, Missouri
2020-08-07
Active, closed
Open-label Extension of the HOPE-2 Trial
NCT04428476Duchenne Muscular Dystrophy
DrugDeramiocel
Capricor Inc.
Phase 2
13
California, Colorado, Missouri, Ohio, Wisconsin
2020-08-05
Active, closed
Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)
NCT04509700B-Cell Malignancies
DrugsItacitinib·Parsaclisib·Ibrutinib·Ruxolitinib
Incyte Corporation
Phase 2
112
Alabama, Arizona, California, Colorado, Illinois, Kansas, Maryland, Massachusetts
2020-08-03
Active, closed
Personalized Therapy Study - HFRS (TriageHF) Post Approval Study
NCT04489225Heart Failure
Medtronic
Observational
2,200
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Iowa
2020-08-01
Active, closed
Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS)
NCT04496518Ventricular Tachycardia
Medtronic
Observational
2,200
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Iowa
2020-08-01
Active, closed
Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer
NCT04494425Advanced or Metastatic Breast Cancer
DrugsTrastuzumab deruxtecan·Nab-paclitaxel·Capecitabine·Paclitaxel
AstraZeneca
Phase 3
866
Arizona, Arkansas, California, Colorado, District of Columbia, Florida, Kansas, Kentucky
2020-07-24
Active, closed
MitraClip REPAIR MR Study
NCT04198870Mitral Valve Regurgitation
Abbott Medical Devices
Not applicable
500
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2020-07-21
Active, closed
Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies
NCT04561362Urinary Bladder Neoplasm, Triple Negative Breast Neoplasms, Hormone Receptor Positive, HER2-negative Neoplasms, Hormone Receptor Positive, HER2-low Neoplasms
DrugsZelenectide pevedotin·Keytruda·Pembrolizumab
BicycleTx Limited
Phase 1/2
329
Colorado, Florida, New York, Ohio, Pennsylvania, Tennessee, Texas
2020-07-17
Active, closed
TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
NCT04485013Cancer
DrugsFolfiri·Cetuximab·Pembrolizumab
Tizona Therapeutics, Inc
Phase 1
240
Arizona, California, Colorado, Connecticut, Delaware, District of Columbia, Florida, Illinois
2020-07-14
Active, closed
A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)
NCT04245839Lymphoma, Non-Hodgkin
DrugsBreyanzi·Fludarabine·Cyclophosphamide
Celgene
Phase 2
276
California, Colorado, Connecticut, Illinois, Iowa, Kansas, Maryland, Massachusetts
2020-07-14
Active, closed
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency
NCT04493853Hormone-Sensitive Prostate Cancer
DrugsZytiga·Capivasertib·Abiraterone acetate
AstraZeneca
Phase 3
1,012
Arizona, California, Colorado, Connecticut, Florida, Illinois, Maryland, Michigan
2020-07-13
Active, closed
RETHINK REFLUX Registry
NCT04253392Gastroesophageal Reflux
Ethicon Endo-Surgery
Observational
500
Alabama, Arizona, California, Colorado, Florida, Illinois, Kentucky, Michigan
2020-07-08
Active, closed
Amplatzer Amulet LAAO vs. NOAC
NCT04226547Atrial Fibrillation, Stroke, Bleeding
DrugNOAC
Abbott Medical Devices
Not applicable
2,650
Alabama, Arizona, Arkansas, California, Colorado, District of Columbia, Florida, Georgia
2020-07-07
Active, closed
SELUTION SLR™ 014 In-stent Restenosis
NCT04280029Coronary Restenosis
M.A. Med Alliance S.A.
Not applicable
418
California, Colorado, District of Columbia, Florida, Georgia, Indiana, Kansas, Maryland
2020-07-06
Active, closed
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
NCT04478279Glioblastoma, Melanoma Stage IV, Breast Cancer, Prostate Cancer
DrugTemozolomide
Sapience Therapeutics
Phase 1/2
125
California, Colorado, Illinois, Michigan, New York, North Carolina, Tennessee
2020-07-01
Active, closed
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
NCT04273945Pulmonary Arterial Hypertension
DrugMacitentan
Actelion
Phase 3
935
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa
2020-06-30
Recruiting
A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
NCT04219254Solid Tumor, Adult
DrugKeytruda
BioInvent International AB
Phase 1/2
197
California, Colorado, Minnesota, Oklahoma, Texas
2020-06-29
Recruiting
Efficacy and Safety of the CG-100 Intraluminal Bypass Device
NCT04184973Rectal Cancer, Rectal Tumor, Rectal/Anal
Colospan Ltd.
Not applicable
250
California, Colorado, Michigan, Rhode Island, Utah
2020-06-23
Active, closed
A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)
NCT04437511Alzheimer Disease
DrugDonanemab
Eli Lilly and Company
Phase 3
1,736
Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida, Georgia
2020-06-19
Active, closed
Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC
NCT04295811Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
Lucid Diagnostics, Inc.
Not applicable
784
Colorado, District of Columbia, Florida, Illinois, Louisiana, Maryland, Massachusetts, Michigan
2020-06-18
Active, closed
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma
NCT04270409Plasma Cell Myeloma
DrugsMontelukast·Diphenhydramine·Acetaminophen·Isatuximab
Sanofi
Phase 3
337
California, Colorado, Florida, Massachusetts, North Carolina, Tennessee, Texas
2020-06-16
Active, closed
A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma
NCT04181827Multiple Myeloma
DrugsCilta-cel·Pomalidomide·Bortezomib·Daratumumab
Janssen Research & Development, LLC
Phase 3
419
Alabama, Arizona, California, Colorado, Connecticut, Florida, Iowa, Kansas
2020-06-12
Active, closed
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma
NCT04106219Neuroblastoma
DrugsTopotecan·Cyclophosphamide
Eli Lilly and Company
Phase 1
71
California, Colorado, Illinois, Massachusetts, Ohio, Pennsylvania, Texas
2020-06-11
Active, closed
A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.
NCT04224493Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma
DrugTazemetostat
Epizyme, Inc.
Phase 3
599
Alabama, Arizona, California, Colorado, Florida, Illinois, Michigan, Minnesota
2020-06-11
Active, closed
4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP)
NCT04517149X-Linked Retinitis Pigmentosa
4D Molecular Therapeutics
Phase 1/2
21
Colorado, Florida, Michigan, New York, North Carolina, Oregon, Texas, Utah
2020-06-09
Active, closed
A Study of FCX-007 for Recessive Dystrophic Epidermolysis Bullosa
NCT04213261Recessive Dystrophic Epidermolysis Bullosa
Castle Creek Biosciences, LLC.
Phase 3
6
California, Colorado, Florida, Minnesota, Texas
2020-06-09
Active, closed
A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)
NCT04404660Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia
DrugAUTO1
Autolus Limited
Phase 1/2
153
California, Colorado, Florida, Georgia, Illinois, Kansas, Maryland, Massachusetts
2020-06-03
Active, closed
Safety and Efficacy of ALLO-501A Anti-CD19 Allogeneic CAR T Cells in Adults With Relapsed/Refractory Large B Cell Lymphoma, Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (ALPHA2)
NCT04416984Relapsed or Refractory Large B Cell Lymphoma, Relapsed or Refractory Chronic Lymphocytic Leukemia, Relapsed or Refractory Small Lymphocytic Lymphoma
DrugsALLO-647·Fludarabine·Cyclophosphamide
Allogene Therapeutics
Phase 1/2
160
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Kentucky
2020-05-21
Active, closed
Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignancies
NCT04349436Merkel Cell Carcinoma, Basal Cell Carcinoma, Locally Advanced Cutaneous Squamous Cell Carcinoma, Cancer
Replimune, Inc.
Phase 1/2
69
Arizona, California, Colorado, Florida, Massachusetts, Minnesota, Missouri, New York
2020-05-15
Active, closed
Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma
NCT04246047Multiple Myeloma
DrugsBelantamab mafodotin·Bortezomib·Daratumumab·Dexamethasone
GlaxoSmithKline
Phase 3
494
Arizona, Colorado, Kansas, Ohio, Texas
2020-05-07
Active, closed
Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
NCT04269200Endometrial Neoplasms
DrugsOlaparib·Durvalumab·Paclitaxel·Carboplatin
AstraZeneca
Phase 3
805
Arizona, California, Colorado, Florida, Georgia, Hawaii, Illinois, Indiana
2020-05-05
Recruiting
Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
NCT04142437Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion
DrugLarotrectinib
Bayer
Observational
150
Arizona, California, Colorado, Connecticut, Florida, Indiana, Kansas, Maine
2020-04-03
Active, closed
Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
NCT04162210Multiple Myeloma
DrugsBelantamab mafodotin·Dexamethasone
GlaxoSmithKline
Phase 3
325
Arizona, Colorado, Michigan, Nebraska, New York, Ohio, Oregon, Texas
2020-04-02
Active, closed
A Clinical Evaluation of the MicroSTent® PeripherAl Vascular SteNt in Subjects With Arterial Disease Below the Knee (STAND)
NCT03477604Peripheral Arterial Disease
Micro Medical Solution, Inc.
Not applicable
177
Alabama, Arizona, California, Colorado, Florida, Iowa, Louisiana, Maryland
2020-03-31
Active, closed
Enfortumab Vedotin and Pembrolizumab vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer
NCT04223856Urothelial Cancer
DrugsEnfortumab Vedotin·Keytruda·Gemcitabine·Cisplatin
Astellas Pharma Global Development, Inc.
Phase 3
886
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Louisiana
2020-03-30
By invitation
Stronger Together Global Registry
NCT04364295Spinal Disease
SeaSpine, Inc.
Observational
2,285
Colorado, Ohio
2020-03-20
Active, closed
Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD
NCT04229017Degenerative Disc Disease
Providence Medical Technology, Inc.
Not applicable
236
Arizona, California, Colorado, Illinois, Kentucky, Louisiana, Maryland, Michigan
2020-03-18
Recruiting
A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
NCT04094610Locally Advanced Solid Tumors, Metastatic Solid Tumors, Lymphoma, Primary CNS Tumors
DrugRepotrectinib
Turning Point Therapeutics, Inc.
Phase 1/2
75
California, Colorado, Florida, Georgia, Maine, Massachusetts, Missouri, New Jersey
2020-03-12
Active, closed
A Study to Evaluate Enfortumab Vedotin in Subjects With Locally Advanced or Metastatic Malignant Solid Tumors (EV-202)
NCT04225117Locally Advanced or Metastatic Malignant Solid Tumors
DrugsEnfortumab Vedotin·Keytruda·Pembrolizumab
Astellas Pharma Global Development, Inc.
Phase 2
329
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas
2020-03-10
Recruiting
Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT04221542Prostate Cancer
DrugsXaluritamig·Abiraterone·Enzalutamide
Amgen
Phase 1
479
California, Colorado, Connecticut, Georgia, Indiana, Kansas, Louisiana, Missouri
2020-03-04
Active, closed
A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)
NCT04195750Carcinoma, Renal Cell
DrugsBelzutifan·Everolimus
Merck Sharp & Dohme LLC
Phase 3
755
Alabama, California, Colorado, District of Columbia, Georgia, Illinois, Louisiana, Maryland
2020-02-27
Active, closed
Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Non-small Cell Lung Cancer (NSCLC), Ovarian Cancer, or Breast Cancer
NCT03937154Chemotherapy-induced Thrombocytopenia
DrugsNplate·Romiplostim
Amgen
Phase 3
145
Arkansas, California, Colorado, Florida, Idaho, Illinois, Louisiana, Maryland
2020-02-26
Active, closed
Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors
NCT04262466Select Advanced Solid Tumors
DrugBrenetafusp
Immunocore Ltd
Phase 1/2
410
California, Colorado, District of Columbia, Florida, Illinois, Iowa, Massachusetts, New Jersey
2020-02-25
Active, closed
Long-term Follow-up Study of Patients Receiving Onasemnogene Abeparvovec-xioi
NCT04042025Spinal Muscular Atrophy Type I, Spinal Muscular Atrophy Type II, Spinal Muscular Atrophy Type III, SMA
DrugsOnasemnogene Abeparvovec-xioi·Zolgensma
Novartis Gene Therapies
Phase 3
85
California, Colorado, Illinois, Maryland, Massachusetts, Michigan, Missouri, New York
2020-02-10
Active, closed
Optilume™ BPH Catheter System in Men With Symptomatic BPH
NCT04131907Benign Prostatic Hyperplasia
Urotronic Inc.
Not applicable
162
Arkansas, Colorado, Florida, Illinois, Louisiana, Maryland, Nevada, New Jersey
2020-02-05
Active, closed
A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described
NCT04122976Prostate Cancer
DrugDarolutamide
Bayer
Observational
805
Alabama, Arizona, California, Colorado, Florida, Illinois, Indiana, Kansas
2020-01-30
Recruiting
A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
NCT05999994Neoplasms, Child, Adolescent
DrugsRamucirumab·Vinorelbine·Abemaciclib·Temozolomide
Eli Lilly and Company
Phase 2
105
Alabama, Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois
2020-01-22
Active, closed
Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy
NCT03970343Heart Failure
Impulse Dynamics
Observational
620
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Indiana
2020-01-21
Recruiting
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in Patients With Advanced Solid Tumor
NCT04192344Neoplasms, Tenosynovial Giant Cell Tumor
DrugPimicotinib
Abbisko Therapeutics Co, Ltd
Phase 1
276
California, Colorado, Georgia, Texas
2020-01-20
Active, closed
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension
NCT04175600Hypertension, Pulmonary
DrugSelexipag
Actelion
Phase 3
138
Arizona, California, Colorado, District of Columbia, Florida, Indiana, Michigan, Ohio
2020-01-16
Active, closed
A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib
NCT04170283B-cell Malignancies
DrugsZanubrutinib·Tislelizumab
BeOne Medicines
Phase 3
955
Arizona, Arkansas, Colorado, Florida, Massachusetts, Michigan, Minnesota, Mississippi
2020-01-16
Active, closed
PROACTIVE-HF IDE Trial Heart Failure NYHA Class III
NCT04089059Heart Failure NYHA Class III
Endotronix, Inc.
Not applicable
738
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Hawaii
2020-01-10
Active, closed
A Study of Ocrelizumab in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis
NCT04075266Multiple Sclerosis
DrugOcrelizumab
Hoffmann-La Roche
Phase 2
23
Colorado, District of Columbia, Massachusetts, Missouri, Ohio
2020-01-09
Active, closed
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study
NCT03901807Septic Shock, Endotoxemia
Spectral Diagnostics (US) Inc.
Not applicable
150
Alabama, Arkansas, California, Colorado, District of Columbia, Georgia, Louisiana, Massachusetts
2020-01-09
Active, closed
Phase 1/2a Clinical Trial of PR001 (LY3884961) in Patients With Parkinson's Disease With at Least One GBA1 Mutation (PROPEL)
NCT04127578Parkinson Disease
DrugsSirolimus·Methylprednisolone
Prevail Therapeutics
Phase 1/2
32
Arizona, California, Colorado, Florida, Illinois, Minnesota, New York, Pennsylvania
2020-01-03
Active, closed
Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Solid Tumors
NCT03967223Neoplasms
DrugsFludarabine·Cyclophosphamide
USWM CT, LLC
Phase 2
103
California, Colorado, Florida, Illinois, Iowa, Massachusetts, Michigan, Minnesota
2019-12-31
Active, closed
A Study of Sasanlimab in People With Non-muscle Invasive Bladder Cancer
NCT04165317Non-muscle Invasive Bladder Cancer
DrugsSasanlimab·Bacillus Calmette-Guerin
Pfizer
Phase 3
1,068
Arizona, Arkansas, California, Colorado, Florida, Illinois, Louisiana, Maryland
2019-12-30
Active, closed
Open-Label Extension: Tolerability and Effects of ALK-001 on Stargardt Disease (TEASE)
NCT04239625Stargardt Disease, Stargardt Macular Degeneration, Stargardt Macular Dystrophy, Autosomal Recessive Stargardt Disease 1 (ABCA4-related)
DrugALK-001
Alkeus Pharmaceuticals, Inc.
Phase 2
200
Arizona, California, Colorado, Florida, Indiana, Michigan, New York, Washington
2019-12-20
Active, closed
Transforaminal Lumbar Interbody Fusion (TLIF)
NCT04073563Degenerative Disease of the Lumbosacral Spine
Medtronic Spinal and Biologics
Not applicable
600
Arizona, California, Colorado, Connecticut, Florida, Illinois, Indiana, Iowa
2019-12-19
Recruiting
Terumo Aortic Global Endovascular Registry
NCT04246463Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery
Vascutek Ltd.
Observational
1,000
California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Indiana, Michigan
2019-12-17
Active, closed
Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)
NCT04185883Advanced Solid Tumors, Kirsten Rat Sarcoma (KRAS) pG12C Mutation
DrugsBI 1701963·TNO155·Sotorasib·Afatinib
Amgen
Phase 1
610
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2019-12-17
Recruiting
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
NCT04176198Myelofibrosis
DrugsMomelotinib·Ruxolitinib
Sumitomo Pharma America, Inc.
Phase 1/2
240
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2019-12-16
Active, closed
Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: The STEMI-DTU Trial
NCT03947619ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
Abiomed Inc.
Not applicable
527
Alabama, Arizona, California, Colorado, Connecticut, Delaware, District of Columbia, Florida
2019-12-12
Recruiting
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial
NCT04097145Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
Edwards Lifesciences
Not applicable
1,270
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa
2019-12-11
Active, closed
Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG)
NCT04146051Myasthenia Gravis, Generalized
DrugDescartes-08
Cartesian Therapeutics
Phase 2
30
California, Colorado, Florida, Georgia, Kansas, New York, North Carolina, Oregon
2019-12-04
Recruiting
Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)
NCT04202341Generalized Myasthenia Gravis
Alexion Pharmaceuticals, Inc.
Observational
500
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia
2019-12-02
Active, closed
M6-C Post Approval Study (PAS)
NCT04122248Cervical Degenerative Disc Disease, Cervical Radiculopathy, Cervical Spinal Cord Compression, Cervical Disc Herniation
Spinal Kinetics
Observational
152
Arizona, California, Colorado, Connecticut, District of Columbia, Illinois, Indiana, Louisiana
2019-11-30
Recruiting
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
Abbott Medical Devices
Observational
1,000
Arizona, California, Colorado, Florida, Illinois, Indiana, Kansas, Kentucky
2019-11-26
Active, closed
Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
NCT04013685Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Myelodysplastic Syndromes, Acute Leukemia
DrugOrca-T
Orca Biosystems, Inc.
Phase 1
155
California, Colorado, Florida, Georgia, Illinois, Kansas, Massachusetts, Michigan
2019-11-21
Active, closed
An Extension Study of Ublituximab in Participants With Relapsing Multiple Sclerosis
NCT04130997Relapsing Multiple Sclerosis (RMS)
DrugUblituximab
TG Therapeutics, Inc.
Phase 3
1,100
California, Colorado, Florida, Illinois, Kansas, Michigan, Nevada, New Jersey
2019-11-18
Active, closed
A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma
NCT04047251Advanced Solid Tumors, Merkel Cell Carcinoma
Fujifilm Pharmaceuticals U.S.A., Inc.
Phase 1
96
Arizona, Colorado, Massachusetts, New York, Ohio, Texas, Wisconsin
2019-11-14
Active, closed
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
NCT04180371Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer, Ovarian Cancer, Non-small Cell Lung Cancer
DrugsNuzefatide pevedotin·Opdivo·Nivolumab
BicycleTx Limited
Phase 1/2
288
California, Colorado, Florida, Michigan, Nevada, New York, Oklahoma, Pennsylvania
2019-11-07
Active, closed
The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry (ProActive)
NCT04091984Kidney Transplant Rejection
Natera, Inc.
Observational
5,000
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Illinois
2019-11-06
Recruiting
A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation
NCT04065399Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Mixed Lineage Acute Leukemia, Mixed Phenotype Acute Leukemia
DrugsCobicistat·Revumenib
Syndax Pharmaceuticals
Phase 1/2
447
California, Colorado, Florida, Georgia, Illinois, Iowa, Massachusetts, Missouri
2019-11-05
Active, closed
Study of Ifinatamab Deruxtecan (DS-7300a, I-DXd) in Participants With Advanced Solid Malignant Tumors
NCT04145622Advanced Solid Tumor, Malignant Solid Tumor
DrugIfinatamab Deruxtecan
Daiichi Sankyo
Phase 1/2
247
Colorado, Florida, Massachusetts, Michigan, Missouri, New Jersey, New York, Tennessee
2019-11-03
Active, closed
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.
NCT04157348Eosinophilic Granulomatous Vasculitis
DrugsBenralizumab·Mepolizumab
AstraZeneca
Phase 3
140
Colorado, Michigan, Minnesota, New Mexico, New York, Pennsylvania, Texas, Washington
2019-10-29
Active, closed
Effectiveness Study of Nivolumab Compared to Placebo in Prevention of Recurrent Melanoma After Complete Resection of Stage IIB/C Melanoma
NCT04099251Melanoma
DrugsOpdivo·Nivolumab
Bristol-Myers Squibb
Phase 3
790
Alabama, Arizona, Arkansas, California, Colorado, District of Columbia, Georgia, Illinois
2019-10-28
Active, closed
Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia A
NCT03932201Hemophilia A
DrugDamoctocog alfa pegol
Bayer
Observational
371
Alabama, Arizona, California, Colorado, District of Columbia, Louisiana, Minnesota, North Carolina
2019-10-21
Active, closed
Study of Sacituzumab Govitecan in Participants With Metastatic Solid Tumors
NCT03964727Metastatic Solid Tumor
DrugSacituzumab Govitecan
Gilead Sciences
Phase 2
227
Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Illinois, Indiana
2019-10-15
Recruiting
Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)
NCT04150497B-cell Acute Lymphoblastic Leukemia
DrugAlemtuzumab
Cellectis S.A.
Phase 1/2
52
California, Colorado, Illinois, Massachusetts, New York, Pennsylvania, Tennessee, Texas
2019-10-14
Active, closed
Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer
NCT04050436Cutaneous Squamous Cell Carcinoma, Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
DrugsVusolimogene Oderparepvec·Cemiplimab
Replimune, Inc.
Phase 2
231
California, Colorado, Florida, Georgia, New Jersey, New York, North Carolina, Ohio
2019-10-08
Active, closed
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene
NCT04123626Autosomal Dominant Retinitis Pigmentosa, Eye Diseases, Eye Diseases, Hereditary, Retinal Dystrophies
ProQR Therapeutics
Phase 1/2
11
Colorado, Florida, Kentucky, Oregon, Texas
2019-10-07
Active, closed
Virta Health Registry
NCT03474692Multiple Chronic Conditions, Chronic Disease, Disease Progression, Long-Term Care
Virta Health
Observational
50,000
Colorado
2019-10-07
Active, closed
SyncAV Post-Market Trial
NCT04100148Congestive Heart Failure
Abbott Medical Devices
Not applicable
1,686
Alabama, Arizona, California, Colorado, Florida, Georgia, Iowa, Kentucky
2019-10-03
Recruiting
Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN
NCT03955445C3 Glomerulopathy, Immune-complex-membranoproliferative Glomerulonephritis
DrugIptacopan
Novartis Pharmaceuticals
Phase 3
225
Colorado, Georgia, Iowa, Minnesota, New York
2019-10-03
Active, closed
A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer
NCT03975647HER2-positive Breast Cancer
DrugsTucatinib·Trastuzumab emtansine
Seagen, a wholly owned subsidiary of Pfizer
Phase 3
466
Alabama, Arizona, California, Colorado, District of Columbia, Florida, Georgia, Hawaii
2019-10-02
Active, closed
Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations
NCT04006210Parkinson's Disease
NeuroDerm Ltd.
Phase 3
381
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Hawaii
2019-09-30
Active, closed
A Study to Evaluate Efficacy, Safety & Pharmacokinetics of the Port Delivery System (PDS) With Ranibizumab in Participants With Diabetic Macular Edema (DME) Compared With Intravitreal Ranibizumab; A Substudy to Evaluate the Safety of Re-implanting the PDS With Ranibizumab in Participants With DME
NCT04108156Diabetic Macular Edema
DrugsPDS Implant with Ranibizumab·Ranibizumab
Hoffmann-La Roche
Phase 3
672
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa
2019-09-30
Active, closed
A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)
NCT03989414Multiple Myeloma
DrugsElotuzumab·Mezigdomide·Isatuximab·Carfilzomib
Celgene
Phase 1/2
424
Colorado, Florida, Georgia, Illinois, Massachusetts, Michigan, Minnesota, New Jersey
2019-09-30
Active, closed
MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas
NCT03962543Plexiform Neurofibroma, Neurofibromatosis Type 1 (NF1)
DrugMirdametinib
SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
Phase 2
114
Alabama, Arizona, Arkansas, California, Colorado, Delaware, District of Columbia, Florida
2019-09-29
Active, closed
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04033445Ulcerative Colitis
DrugGuselkumab
Janssen Research & Development, LLC
Phase 2/3
1,064
California, Colorado, Florida, Georgia, Illinois, Kansas, Kentucky, Massachusetts
2019-09-26
Active, closed
Clinical Trial to Evaluate Zevor-cel (CT053) in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 2)
NCT03915184Multiple Myeloma
CARsgen Therapeutics Co., Ltd.
Phase 1/2
105
Arizona, California, Colorado, Florida, Massachusetts, Minnesota, Tennessee, Texas
2019-09-25
By invitation
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
NCT03683186PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension
United Therapeutics
Phase 3
1,000
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa
2019-09-23
Active, closed
Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's Disease
NCT04120493Huntington's Disease
UniQure Biopharma B.V.
Phase 1/2
43
Alabama, Arizona, California, Colorado, Illinois, Maryland, Michigan, Ohio
2019-09-06
Active, closed
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
NCT03950232Ulcerative Colitis
DrugEtrasimod
Pfizer
Phase 3
896
Alabama, California, Colorado, Florida, Georgia, Illinois, Louisiana, Maryland
2019-09-05
Active, closed
Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET
NCT03993873Advanced Solid Tumor, Metastatic Solid Tumors, MET Gene Alterations
Turning Point Therapeutics, Inc.
Phase 1
95
California, Colorado, Illinois, Massachusetts, Michigan, Missouri, Ohio, Texas
2019-09-05
Active, closed
TRILUMINATE Pivotal Trial
NCT03904147Tricuspid Regurgitation
Abbott Medical Devices
Not applicable
572
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2019-08-21
Active, closed
Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia
NCT04119050Warm Autoimmune Hemolytic Anemia
DrugNipocalimab
Janssen Research & Development, LLC
Phase 2/3
118
California, Colorado, Florida, Illinois, Kansas, Louisiana, Michigan, Missouri
2019-08-15
Active, closed
Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
NCT04044768Synovial Sarcoma, Myxoid Liposarcoma
USWM CT, LLC
Phase 2
52
California, Colorado, Florida, Illinois, Maryland, Massachusetts, Michigan, Missouri
2019-08-13
Recruiting
A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors
NCT03972657Metastatic Castration-Resistant Prostate Cancer (mCRPC), Clear Cell Renal Cell Carcinoma (ccRCC)
DrugsNezastomig·Cemiplimab
Regeneron Pharmaceuticals
Phase 1/2
345
Arizona, California, Colorado, Connecticut, Florida, Massachusetts, Michigan, Minnesota
2019-08-12
Recruiting
Pan Tumor Rollover Study
NCT03899155Cancer
DrugsRucaparib·Sunitinib·Trametinib·Relatlimab
Bristol-Myers Squibb
Phase 2
1,500
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Illinois
2019-08-09
Active, closed
2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C
NCT04012996Symptomatic Cervical Disc Disease
Centinel Spine
Not applicable
390
Arizona, California, Colorado, District of Columbia, Florida, Indiana, Kentucky, Louisiana
2019-08-05
Active, closed
A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)
NCT04008030Metastatic Colorectal Cancer
DrugsFluorouracil·Leucovorin·Ipilimumab·Cetuximab
Bristol-Myers Squibb
Phase 3
839
California, Colorado, Illinois, New York, Oregon, Pennsylvania, Texas, Virginia
2019-08-05
Active, closed
A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B
NCT03861273Hemophilia B
Pfizer
Phase 3
51
California, Colorado, Indiana, Mississippi, Pennsylvania
2019-07-29
Recruiting
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
NCT03821129Stroke, PFO - Patent Foramen Ovale
W.L.Gore & Associates
Not applicable
636
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa
2019-07-25
Active, closed
Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303)
NCT03924895Urinary Bladder Cancer, Muscle-invasive
DrugsEnfortumab Vedotin·Keytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
595
Alabama, Arkansas, California, Colorado, District of Columbia, Georgia, Illinois, Indiana
2019-07-24
Active, closed
Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer
NCT04046445Colorectal Cancer, MSS, Stage IV Colon Cancer, Stage IV Rectal Cancer
DrugEzabenlimab
Amal Therapeutics
Phase 1
96
Arizona, California, Colorado, New York, North Carolina, Texas
2019-07-22
Active, closed
Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine
NCT03836040Migraine
Amgen
Phase 3
457
California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois, Indiana
2019-07-19
Active, closed
An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)
NCT03897881Melanoma
DrugsIntismeran autogene·Pembrolizumab
ModernaTX, Inc.
Phase 2
267
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2019-07-18
Active, closed
Citadel Embolization Device Study
NCT04057352Unruptured Wide-neck Aneurysms
Stryker Neurovascular
Not applicable
150
California, Colorado, Florida, Illinois, Indiana, Kansas, Kentucky, Massachusetts
2019-07-18
Active, closed
Extension Study for Participants in LIQ861 Trials to Evaluate the Long-term Safety of Dry Powder Inhalation of Treprostinil
NCT03992755Primary Pulmonary Hypertension
DrugTreprostinil
Liquidia Technologies, Inc.
Phase 3
92
Arizona, California, Colorado, Florida, Georgia, Illinois, Kansas, Louisiana
2019-07-18
Active, closed
A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor
NCT04008797Endometrial Neoplasms, Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms
DrugsE7386·Doxorubicin·Lenvatinib·Paclitaxel
Eisai Inc.
Phase 1/2
301
Arkansas, California, Colorado, Florida, Louisiana, Mississippi, Missouri, New York
2019-07-11
Active, closed
Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)
NCT03974022Non-Small Cell Lung Cancer
DrugSunvozertinib
Dizal Pharmaceuticals
Phase 1/2
315
California, Colorado, Florida, Massachusetts, Michigan, New York, Ohio, Virginia
2019-07-09
Active, closed
IBP-9414 for the Prevention of Necrotizing Enterocolitis - The Connection Study
NCT03978000Necrotizing Enterocolitis
Infant Bacterial Therapeutics
Phase 3
2,158
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois
2019-07-04
Recruiting
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
NCT03947385Metastatic Uveal Melanoma, Cutaneous Melanoma, Colorectal Cancer, Other Solid Tumors
DrugsDarovasertib·Binimetinib·Crizotinib
IDEAYA Biosciences
Phase 1/2
336
California, Colorado, Iowa, Michigan, New York, North Carolina, Ohio, Pennsylvania
2019-06-28
Active, closed
Study of Efficacy and Safety of Tisagenlecleucel in HR B-ALL EOC MRD Positive Patients
NCT03876769B-Cell Acute Lymphoblastic Leukemia
DrugTisagenlecleucel
Novartis Pharmaceuticals
Phase 2
121
Alabama, Arizona, California, Colorado, District of Columbia, Florida, Georgia, Indiana
2019-06-24
Active, closed
remedē System Therapy Study
NCT03884660Central Sleep Apnea
Respicardia, Inc.
Observational
225
Arizona, California, Colorado, Florida, Georgia, Illinois, Kentucky, Michigan
2019-06-18
Active, closed
A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors
NCT03899792Medullary Thyroid Cancer, Infantile Myofibromatosis, Infantile Fibrosarcoma, Papillary Thyroid Cancer
DrugSelpercatinib
Eli Lilly and Company
Phase 1/2
36
California, Colorado, Florida, Massachusetts, Minnesota, New York, Ohio, Pennsylvania
2019-06-13
Active, closed
A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
NCT03767244Prostatic Neoplasms
DrugApalutamide
Janssen Research & Development, LLC
Phase 3
2,517
California, Colorado, Connecticut, Florida, Georgia, Illinois, Louisiana, Massachusetts
2019-06-11
Active, closed
A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsy
NCT04015141Pediatric Epileptic Syndrome, Partial-onset Seizures
DrugPerampanel
Eisai Inc.
Phase 2
100
California, Colorado, Florida, Georgia, Michigan, New Jersey, North Carolina, Ohio
2019-05-31
Active, closed
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
NCT03709680Ewing Sarcoma, Solid Tumors, Rhabdoid Tumor, Rhabdomyosarcoma
DrugsTemodar·Topotecan·Cytoxan·Palbociclib
Pfizer
Phase 2
128
Alabama, Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois
2019-05-24
Recruiting
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
NCT03686124Refractory Cancer, Recurrent Cancer, Solid Tumor, Adult, Cancer
DrugsAnzu-cel·Opdivo·Nivolumab
Immatics US, Inc.
Phase 1/2
375
California, Colorado, Florida, Illinois, Massachusetts, New York, Ohio, Pennsylvania
2019-05-14
Active, closed
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
NCT03811561Diabetes Mellitus, Type 2
DrugSemaglutide
Novo Nordisk A/S
Phase 3
1,500
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2019-05-08
Recruiting
A Trial of Etelcalcetide in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis
NCT03633708Secondary Hyperparathyroidism, Chronic Kidney Disease
DrugEtelcalcetide
Amgen
Phase 3
56
California, Colorado, Missouri, New York, Ohio, Oklahoma, Pennsylvania, Texas
2019-04-29
Active, closed
Extension Study to Evaluate Safety and Efficacy of CTP-543 in Adults With Alopecia Areata
NCT03898479Alopecia Areata
Sun Pharmaceutical Industries, Inc.
Phase 2/3
1,000
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Idaho
2019-04-04
Active, closed
A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis
NCT03900429NASH - Nonalcoholic Steatohepatitis
DrugResmetirom
Madrigal Pharmaceuticals, Inc.
Phase 3
1,759
Alabama, Arizona, Arkansas, California, Colorado, Florida, Georgia, Illinois
2019-03-28
Active, closed
A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease
NCT03887455Early Alzheimer's Disease
DrugLecanemab
Eisai Inc.
Phase 3
1,906
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Hawaii
2019-03-27
Active, closed
Intra-operative Pancreatoscopy in Patients With IPMN
NCT03729453Intraductal Papillary Mucinous Neoplasm
Boston Scientific Corporation
Observational
100
Colorado, Indiana, Maryland
2019-03-20
Active, closed
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer
NCT03860272Advanced Cancer, Angiosarcoma, Colorectal Cancer Without Liver Metastases, Endometrial Cancer
DrugsBalstilimab·Botensilimab
Agenus Inc.
Phase 1
499
Arizona, California, Colorado, Connecticut, Florida, Massachusetts, New York, Oregon
2019-03-20
Active, closed
Troriluzole in Adult Participants With Spinocerebellar Ataxia
NCT03701399Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3
DrugTroriluzole
Biohaven Pharmaceuticals, Inc.
Phase 3
299
Arizona, California, Colorado, Florida, Georgia, Illinois, Maryland, Massachusetts
2019-03-08
Active, closed
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
NCT03768063Cancer
DrugsEmactuzumab·Rucaparib·Cobimetinib·Vemurafenib
Hoffmann-La Roche
Phase 3
1,000
Colorado, Connecticut, Massachusetts, North Carolina, Pennsylvania, Texas
2019-02-28
Recruiting
ProACT Post-Approval Study
NCT03767595Stress Urinary Incontinence
Uromedica
Not applicable
145
California, Colorado, Florida, Georgia, Kansas, Michigan, Minnesota, Nebraska
2019-02-19
Active, closed
A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib
NCT03673501Gastrointestinal Stromal Tumors
DrugsRipretinib·Sunitinib
Deciphera Pharmaceuticals, LLC
Phase 3
453
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2019-02-08
Active, closed
Clinical Trial Multi-analyte Blood Test
NCT03694600Liver Cirrhosis
Helio Genomics
Observational
1,900
Arizona, California, Colorado, Florida, Georgia, Illinois, Kansas, Kentucky
2019-02-04
Active, closed
A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy
NCT03796962Focal Epilepsy
DrugAzetukalner
Xenon Pharmaceuticals Inc.
Phase 2
325
Alabama, Arizona, Arkansas, California, Colorado, Florida, Georgia, Hawaii
2019-01-30
Active, closed
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer
NCT03748641Castration-Resistant Prostatic Cancer
DrugsAbiraterone acetate·Niraparib·Prednisone
Janssen Research & Development, LLC
Phase 3
765
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Illinois
2019-01-25
Recruiting
A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System
NCT05653102Knee Arthroplasty, Total
Exactech
Observational
1,000
Colorado, Florida, Nevada, Ohio, South Carolina
2019-01-23
Recruiting
Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known as the COMPOSE Study)
NCT03406611Homocystinuria
DrugPegtibatinase
Travere Therapeutics, Inc.
Phase 1/2
39
Colorado, Florida, Illinois, Indiana, Maine, Massachusetts, New York, North Carolina
2019-01-22
Active, closed
Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
NCT03785249Advanced Cancer, Metastatic Cancer, Malignant Neoplastic Disease
DrugsAdagrasib·Afatinib·Cetuximab·Pembrolizumab
Mirati Therapeutics Inc.
Phase 1/2
731
Alabama, Alaska, Arizona, California, Colorado, Connecticut, Delaware, Florida
2019-01-15
Active, closed
Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS
NCT03650114Relapsing Multiple Sclerosis
Drugs13-valent pneumococcal conjugate vaccine·23-valent pneumococcal polysaccharide vaccine·Ofatumumab
Novartis Pharmaceuticals
Phase 3
1,882
Alabama, Arizona, California, Colorado, Delaware, Florida, Georgia, Hawaii
2018-12-28
Active, closed
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
NCT03725059Breast Cancer
DrugsEpirubicin·Adriamycin·Cytoxan·Taxol
Merck Sharp & Dohme LLC
Phase 3
1,240
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2018-12-27
Active, closed
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)
NCT03711032High-risk Non-muscle Invasive Bladder Cancer
DrugsKeytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,397
Alaska, Arizona, California, Colorado, Florida, Georgia, Illinois, Kansas
2018-12-24
Active, closed
Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)
NCT03765918Head and Neck Neoplasms
DrugsKeytruda·Cisplatin·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
714
California, Colorado, District of Columbia, Florida, Idaho, Illinois, Kansas, Kentucky
2018-12-17
Active, closed
Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)
NCT03742895Advanced Solid Neoplasms
DrugOlaparib
Merck Sharp & Dohme LLC
Phase 2
329
Arizona, California, Colorado, Georgia, Kentucky, Maryland, Massachusetts, Michigan
2018-12-12
Active, closed
A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy
NCT03762850Immunoglobulin A Nephropathy
DrugsSparsentan·Irbesartan·Dapagliflozin
Travere Therapeutics, Inc.
Phase 3
406
Alabama, California, Colorado, Florida, Georgia, Idaho, Illinois, Indiana
2018-12-11
Active, closed
A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer
NCT03701334Early Breast Cancer
DrugRibociclib
Novartis Pharmaceuticals
Phase 3
5,101
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia
2018-12-07
Active, closed
A Study of Neoadjuvant/Adjuvant Durvalumab for the Treatment of Patients With Resectable Non-small Cell Lung Cancer
NCT03800134Non-Small Cell Lung Cancer
DrugsDurvalumab·Pemetrexed·Gemcitabine·Paclitaxel
AstraZeneca
Phase 3
825
Arizona, California, Colorado, Florida, Illinois, Kansas, Kentucky, Maryland
2018-12-06
Active, closed
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
NCT03706833Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
Edwards Lifesciences
Not applicable
1,247
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Indiana
2018-11-30
Active, closed
A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer
NCT03706365Prostate Cancer
DrugsAbiraterone acetate·Abemaciclib·Prednisone
Eli Lilly and Company
Phase 2/3
393
Arizona, Arkansas, California, Colorado, Florida, Georgia, Indiana, Massachusetts
2018-11-26
Recruiting
Study to Evaluate the Safety and Efficacy of the Cytrellis Micro-Coring Device for the Treatment of Moderate to Severe Facial Wrinkles
NCT03793348Wrinkle
Cytrellis Biosystems, Inc.
Not applicable
35
California, Colorado, Florida, New York, Tennessee, Texas
2018-11-12
Active, closed
Open Label Extension to Assess the Long-Term Safety and Tolerability of ZYN002 in Children and Adolescents With FXS
NCT03802799Fragile X Syndrome
Zynerba Pharmaceuticals, Inc.
Phase 2/3
476
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Maryland
2018-11-09
Active, closed
Early Weight-Bearing After the Lapiplasty Procedure
NCT03740282Hallux Valgus, Bunion
Treace Medical Concepts, Inc.
Not applicable
183
Colorado, Iowa, Missouri, Nevada, Pennsylvania, Texas
2018-11-06
Active, closed
Destination Therapy Post Approval Study
NCT03681210Chronic Heart Failure
Medtronic Cardiac Rhythm and Heart Failure
Observational
300
Arkansas, California, Colorado, Florida, Illinois, Indiana, Kansas, Kentucky
2018-10-31
Active, closed
Study on Olaparib Plus Abiraterone as First-line Therapy in Men With Metastatic Castration-resistant Prostate Cancer
NCT03732820Metastatic Castration-resistant Prostate Cancer
DrugsZytiga·Abiraterone acetate·Olaparib
AstraZeneca
Phase 3
895
Alabama, Alaska, Arizona, California, Colorado, Illinois, Indiana, Louisiana
2018-10-31
Active, closed
A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis
NCT03596645Colitis, Ulcerative
DrugsGolimumab·Infliximab
Janssen Research & Development, LLC
Phase 3
84
California, Colorado, Connecticut, Delaware, Georgia, Minnesota, New York, Tennessee
2018-10-29
Active, closed
Long-Term Follow-Up Study for Subjects Treated With P-BCMA-101
NCT03741127Multiple Myeloma
Poseida Therapeutics, Inc.
Phase 1
100
California, Colorado, Illinois, Kansas, Maryland, Michigan, Pennsylvania, Tennessee
2018-10-29
Active, closed
A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.
NCT03539744Multiple Myeloma
DrugsPomalidomide·Venetoclax·Dexamethasone
AbbVie
Phase 3
265
Arizona, California, Colorado, Florida, Kentucky, Maryland, Massachusetts, Michigan
2018-10-22
Active, closed
Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer.
NCT03616587ER+ HER2- Advanced Breast Cancer
DrugCamizestrant
AstraZeneca
Phase 1
396
Colorado, Florida, Pennsylvania, Tennessee, Utah
2018-10-11
Active, closed
Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer
NCT03539536Non-small Cell Lung Cancer
DrugTelisotuzumab vedotin
AbbVie
Phase 2
270
Alabama, Arizona, Arkansas, California, Colorado, Florida, Hawaii, Illinois
2018-10-10
Recruiting
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
NCT03715933Ewing Sarcoma, Colorectal Adenocarcinoma
DrugsINBRX-109·Temozolomide·Fluorouracil·Leucovorin
Inhibrx Biosciences, Inc
Phase 1
411
Arizona, California, Colorado, Georgia, Illinois, Michigan, New York, Ohio
2018-10-08
Active, closed
A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
NCT03690388Differentiated Thyroid Cancer
DrugCabozantinib
Exelixis
Phase 3
187
California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Kentucky, Massachusetts
2018-10-05
Active, closed
A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma
NCT03671018B-cell Non-Hodgkin Lymphoma
DrugsMosunetuzumab·Polatuzumab Vedotin·Tocilizumab·Rituximab
Hoffmann-La Roche
Phase 1/2
422
Alabama, California, Colorado, Florida, Michigan, New York, North Carolina, Pennsylvania
2018-09-25
Active, closed
Study to Evaluate the Safety and Efficacy of BF-200 ALA (Ameluz®) and BF-RhodoLED® in the Treatment of Superficial Basal Cell Carcinoma (sBCC) With Photodynamic Therapy (PDT).
NCT03573401Superficial Basal Cell Carcinoma
Biofrontera Inc.
Phase 3
187
Arizona, California, Colorado, Florida, Indiana, Michigan, New Hampshire, New York
2018-09-25
Recruiting
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157Spinal Muscular Atrophy (SMA)
DrugZolgensma
Novartis Pharmaceuticals
Observational
700
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Indiana, Iowa
2018-09-25
Recruiting
Extension Study for the Port Delivery System With Ranibizumab (Portal)
NCT03683251Neovascular Age-Related Macular Degeneration
DrugPDS Implant with Ranibizumab
Hoffmann-La Roche
Phase 3
1,000
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa
2018-09-20
Active, closed
Reducing Lung CongestIon Symptoms in Advanced Heart Failure
NCT03499236Heart Failure
V-Wave Ltd
Not applicable
605
Arizona, California, Colorado, Florida, Georgia, Illinois, Kentucky, Minnesota
2018-09-19
Active, closed
ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis
NCT03517436Aortic Valve Stenosis
Edwards Lifesciences
Not applicable
101
California, Colorado, District of Columbia, Florida, Georgia, Indiana, Kansas, Massachusetts
2018-09-18
Active, closed
Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716)
NCT03553836Melanoma
DrugsKeytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
976
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Iowa
2018-09-12
Active, closed
Long Term Follow Up to Evaluate DTX301 in Adults With Late-Onset OTC Deficiency
NCT03636438Ornithine Transcarbamylase (OTC) Deficiency
Ultragenyx Pharmaceutical Inc
Observational
11
Colorado, Massachusetts, New York, Ohio
2018-08-30
Active, closed
A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis
NCT03398135Ulcerative Colitis (UC)
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
1,242
California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Kansas
2018-08-28
Active, closed
Evaluation of Efficacy, Safety and Tolerability of VeraCept IUS
NCT03633799Women at Risk for Pregnancy
Sebela Women's Health Inc.
Phase 3
1,620
Arizona, California, Colorado, Florida, Georgia, Idaho, Indiana, Louisiana
2018-08-22
Recruiting
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
NCT03486873Solid Tumors, Hematologic Malignancies
DrugsPembrolizumab/Favezelimab·) Berahyaluronidase alfa·Olaparib·Lenvatinib
Merck Sharp & Dohme LLC
Phase 3
3,500
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Hawaii
2018-08-21
Active, closed
Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood
NCT03793478Acute Myeloid Leukemia
DrugsQuizartinib·Cytarabine·Etoposide·Fludarabine
Daiichi Sankyo
Phase 1/2
65
California, Colorado, Delaware, District of Columbia, Georgia, Minnesota, Ohio, Pennsylvania
2018-08-15
Active, closed
Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread
NCT03547973Metastatic Urothelial Cancer
DrugsDomvanalimab·Zimberelimab·Avelumab·Enfortumab Vedotin
Gilead Sciences
Phase 2
502
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Kentucky
2018-08-13
Active, closed
A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis
NCT03568318Atopic Dermatitis
DrugUpadacitinib
AbbVie
Phase 3
1,533
Alabama, Arizona, California, Colorado, Connecticut, Florida, Idaho, Illinois
2018-08-09
Recruiting
Early Feasibility Study - Edwards APTURE Transcatheter Shunt System
NCT03523416Heart Failure
Edwards Lifesciences
Not applicable
90
California, Colorado, Florida, Indiana, Kansas, Minnesota, New Jersey, New York
2018-07-31
Active, closed
A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension
NCT03492177Pulmonary Arterial Hypertension
DrugSelexipag
Actelion
Phase 2
63
Colorado, Iowa, Washington
2018-07-23
Recruiting
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
NCT03435796Neoplasms
Celgene
Phase 2/3
1,541
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia
2018-07-19
Active, closed
X-linked Hypophosphatemia Disease Monitoring Program
NCT03651505X-linked Hypophosphatemia, Hypophosphatemic Rickets
Ultragenyx Pharmaceutical Inc
Observational
782
Alabama, California, Colorado, Connecticut, Illinois, Indiana, Maryland, Massachusetts
2018-07-16
Active, closed
First-in-Human (FIH) Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma
NCT03625037DLBCL, High-grade B-cell Lymphoma (HGBCL), Primary Mediastinal Large B-cell Lymphoma (PMBCL), FL
DrugEpcoritamab
Genmab
Phase 1/2
666
Arizona, California, Colorado, Florida, Iowa, Louisiana, Michigan, Nebraska
2018-06-26
Active, closed
Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors
NCT03485209Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Exocrine Pancreatic Cancer, Carcinoma, Squamous Cell of Head and Neck
DrugsTisotumab Vedotin·Tivdak·Keytruda·Cisplatin
Seagen, a wholly owned subsidiary of Pfizer
Phase 2
350
California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Kansas
2018-06-25
Active, closed
A Study to Compare Zolbetuximab (IMAB362) and Chemotherapy With Placebo and Chemotherapy in Adults With Gastric Cancer.
NCT03504397Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
DrugsZolbetuximab·Folinic acid·Fluorouracil·Oxaliplatin
Astellas Pharma Global Development, Inc.
Phase 3
565
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Kentucky
2018-06-21
Active, closed
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
NCT03433274Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases
Abbott Medical Devices
Not applicable
103
Alabama, Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho
2018-06-15
Active, closed
A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy
NCT03522246Epithelial Ovarian Cancer, Primary Peritoneal, Fallopian Tube Cancer, Newly Diagnosed
DrugsRucaparib·Opdivo·Nivolumab
pharmaand GmbH
Phase 3
1,097
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2018-05-14
Active, closed
Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study
NCT03381274Carcinoma, Non-Small-Cell Lung
DrugsOleclumab·Tagrisso·Osimertinib
MedImmune LLC
Phase 1/2
43
California, Colorado, Connecticut, Georgia, Illinois, Maryland, New York, Texas
2018-05-08
Active, closed
Extended Access of Momelotinib in Adults With Myelofibrosis
NCT03441113Neoplasms, Post-polycythemia Vera Myelofibrosis (Post-PV MF), Primary Myelofibrosis (PMF), Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)
GlaxoSmithKline
Phase 2
237
Arizona, California, Colorado, Florida, Georgia, Maryland, Massachusetts, Minnesota
2018-05-03
Recruiting
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
NCT03526835Advanced/Metastatic Solid Tumors, Colorectal Cancer, Gastric Cancer, Gastroesophageal-junction Cancer
DrugPetosemtamab
Merus B.V.
Phase 1/2
560
California, Colorado, Florida, Georgia, Massachusetts, Michigan, Missouri, New York
2018-05-02
Active, closed
P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation
NCT03438747Degenerative Disc Disease
CeraPedics, Inc
Not applicable
290
Alabama, California, Colorado, Connecticut, Florida, Illinois, Indiana, Kentucky
2018-04-24
Active, closed
A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
NCT03383458Hepatocellular Carcinoma, Liver Cancer
DrugsOpdivo·Nivolumab
Bristol-Myers Squibb
Phase 3
545
Alabama, Arizona, California, Colorado, Florida, Georgia, Kansas, Louisiana
2018-04-18
Active, closed
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
NCT03466411Crohn's Disease
DrugsGuselkumab 1·Guselkumab 2·Guselkumab 3·Ustekinumab
Janssen Research & Development, LLC
Phase 2/3
1,409
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2018-04-13
Active, closed
Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)
NCT03407144Hodgkin Lymphoma
DrugsPrednisone/Prednisolone·Vinblastine·Bleomycin·Dacarbazine
Merck Sharp & Dohme LLC
Phase 2
340
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2018-04-09
Active, closed
A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease
NCT03105102Crohn's Disease
DrugsSkyrizi·Risankizumab
AbbVie
Phase 3
1,336
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois
2018-04-09
Active, closed
Study of the Safety and Effectiveness of Motiva Implants®
NCT03579901Breast Implants
Motiva USA LLC
Not applicable
800
California, Colorado, Georgia, Illinois, Indiana, Kentucky, Louisiana, Michigan
2018-04-06
Active, closed
A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer
NCT03473743Urothelial Carcinoma
DrugsErdafitinib·Cetrelimab·Cisplatin·Carboplatin
Janssen Research & Development, LLC
Phase 1/2
125
Colorado, Kentucky, Maryland, New Jersey, New York, North Carolina, Ohio, Pennsylvania
2018-04-05
Active, closed
A Study of Combination Therapy With Venetoclax, Daratumumab and Dexamethasone (With and Without Bortezomib) in Participants With Relapsed or Refractory Multiple Myeloma
NCT03314181Multiple Myeloma
DrugsVenclexta·Bortezomib·Daratumumab·Venetoclax
AbbVie
Phase 2
156
Colorado, Florida, Georgia, Illinois, Massachusetts, New Jersey, New York, North Carolina
2018-04-02
Recruiting
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
NCT03424005Metastatic Breast Cancer
DrugsAtirmociclib·Ipatasertib·Giredestrant·Inavolisib
Hoffmann-La Roche
Phase 1/2
1,132
California, Colorado, Florida, Illinois, Minnesota, Nevada, New Jersey, New York
2018-03-30
Recruiting
Use of Bone Marrow Concentrate for Treatment of Alar, Accessory, and Transverse Ligament Injuries
NCT03517761Craniocervical Injuries
Regenexx, LLC
Not applicable
80
Colorado
2018-03-23
Active, closed
A Phase 1 Dose-escalation Study of FF-10832 for Treatment of Solid Tumors Including Biliary Tract Cancer
NCT03440450Advanced Solid Tumors, Biliary Tract Cancer
DrugFF-10832
Fujifilm Pharmaceuticals U.S.A., Inc.
Phase 1
90
Arizona, California, Colorado, Tennessee, Texas, Washington
2018-03-22
Active, closed
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
NCT03345823Crohn's Disease
DrugUpadacitinib
AbbVie
Phase 3
747
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Idaho
2018-03-21
By invitation
Compliant Analysis of Patient Samples and Data
NCT04364503Pregnancy Related, Cancer, Infectious Disease
Sequenom, Inc.
Observational
2,000
California, Colorado, Illinois, New York, North Carolina
2018-03-17
Active, closed
A Study of Galcanezumab (LY2951742) in Participants 6 to 17 Years of Age With Episodic Migraine
NCT03432286Episodic Migraine
DrugGalcanezumab
Eli Lilly and Company
Phase 3
533
Alabama, Arizona, California, Colorado, Florida, Georgia, Idaho, Illinois
2018-03-14
Active, closed
To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.
NCT03330847Metastatic Triple Negative Breast Cancer
DrugCeralasertib
AstraZeneca
Phase 2
273
Alabama, Alaska, Arizona, Colorado, Connecticut, Illinois, Indiana, Kentucky
2018-03-07
Active, closed
A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer
NCT03431350Prostatic Neoplasms, Castration-Resistant
DrugsCetrelimab·Abiraterone acetate·Niraparib·Prednisone
Janssen Research & Development, LLC
Phase 2
136
Arizona, Colorado, Florida, Indiana, Maryland, Michigan, New York, Pennsylvania
2018-03-02
Recruiting
The PREDICT Registry:
NCT03448926DCIS, Stage 0 Breast Cancer, Ductal Breast Carcinoma In Situ
PreludeDx
Observational
3,000
Arizona, California, Colorado, Florida, Georgia, Illinois, Maryland, Massachusetts
2018-02-27
Active, closed
AMPLATZER PFO Occluder Post Approval Study
NCT03309332Stroke, Patent Foramen Ovale
Abbott Medical Devices
Not applicable
1,214
Alabama, Arizona, Arkansas, California, Colorado, District of Columbia, Florida, Georgia
2018-01-31
Recruiting
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
NCT03142152Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases
Cardiac Dimensions, Inc.
Not applicable
300
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Indiana
2018-01-01
Recruiting
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
NCT03452774Cancer, Metastatic, Cancer, Cancer of Pancreas, Cancer of Liver
Massive Bio, Inc.
Observational
50,000
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida
2018-01-01
Active, closed
Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC
NCT03395197mCRPC
Pfizer
Phase 3
1,054
Alaska, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2017-12-18
Active, closed
Dose Escalation Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma
NCT03399799Hematological Malignancies
DrugTalquetamab
Janssen Research & Development, LLC
Phase 1
279
Alabama, California, Colorado, New York, Tennessee
2017-12-16
Active, closed
Study of the RelayPro Thoracic Stent-Graft in Subjects With an Acute, Complicated Type B Aortic Dissection
NCT03033043Aortic Dissection Type B
Bolton Medical
Not applicable
56
California, Colorado, Connecticut, District of Columbia, Georgia, Illinois, Indiana, Iowa
2017-12-14
Active, closed
Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC)
NCT03301506Primary Biliary Cirrhosis
DrugSeladelpar
Gilead Sciences
Phase 3
340
Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois, Louisiana
2017-12-12
Active, closed
Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)
NCT03331198Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Small Lymphocytic
DrugsBreyanzi·Ibrutinib·Venetoclax
Juno Therapeutics, a Subsidiary of Celgene
Phase 1/2
320
Alabama, Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois
2017-11-27
Active, closed
A Study of GDC-9545 Alone or in Combination With Palbociclib and/or Luteinizing Hormone-Releasing Hormone (LHRH) Agonist in Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer
NCT03332797Breast Cancer
DrugsGiredestrant·Palbociclib
Genentech, Inc.
Phase 1
181
Colorado, Massachusetts, New York, Tennessee
2017-11-24
Active, closed
Efficacy, Safety and Tolerability Study of Long-acting Cabotegravir Plus Long-acting Rilpivirine (CAB LA + RPV LA) in Human-immunodeficiency Virus-1 (HIV-1) Infected Adults
NCT03299049HIV Infections
DrugsRilpivirine·Cabotegravir
ViiV Healthcare
Phase 3
1,049
Alabama, Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois
2017-10-27
Active, closed
A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)
NCT03178552Non-Small Cell Lung Cancer
DrugsCobimetinib·Divarasib·Vemurafenib·Entrectinib
Hoffmann-La Roche
Phase 2/3
1,000
California, Colorado, Florida, Kentucky, Nevada, New Hampshire, New York, Oregon
2017-09-22
Active, closed
A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
NCT03148418Cancer
DrugsTecentriq·Avastin·Atezolizumab·Bevacizumab
Hoffmann-La Roche
Phase 3
382
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2017-09-20
Active, closed
ATTUNE® Revision- Complex Primary in Total Knee Arthroplasty Population
NCT03153449Primary Knee Arthroplasty
DePuy Orthopaedics
Not applicable
400
California, Colorado, Connecticut, Florida, Kentucky, Mississippi, New Hampshire, New Jersey
2017-09-19
Active, closed
A Study of Brentuximab Vedotin + Adriamycin, Vinblastine, and Dacarbazine in Pediatric Participants With Advanced Stage Newly Diagnosed Hodgkin Lymphoma
NCT02979522Hodgkin Disease
DrugsVinblastine·Brentuximab Vedotin·Dacarbazine·Adriamycin
Takeda
Phase 1/2
59
Colorado, Ohio
2017-09-06
Active, closed
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
NCT03170960Urothelial Carcinoma, Renal Cell Carcinoma, Non-Small Cell Lung Cancer, Castration-resistant Prostate Cancer
DrugsCabozantinib·Tecentriq·Atezolizumab
Exelixis
Phase 1
914
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2017-09-05
Active, closed
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
NCT02962414Tuberous Sclerosis Complex
DrugEverolimus
Novartis Pharmaceuticals
Phase 3
206
Arizona, California, Colorado, Connecticut, Illinois, Minnesota, New Jersey, Ohio
2017-08-23
Active, closed
ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent
NCT03130777Pulmonary Disease, Transcatheter Pulmonary Valve Replacement (TPVR), Tetralogy of Fallot, Congenital Heart Disease
Edwards Lifesciences
Not applicable
86
California, Colorado, Georgia, Missouri, New York, Ohio, Pennsylvania, Texas
2017-08-22
Active, closed
Personalized Therapy Study - Attain Stability Quad Post-Approval Study
NCT04024943Heart Failure
Medtronic
Observational
1,092
Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia
2017-08-21
Recruiting
Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)
NCT03016819Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma, Soft-Tissue Sarcoma
DrugsCatequentenib·Digoxin·Dacarbazine·Rosuvastatin
Advenchen Laboratories, LLC
Phase 3
325
Arizona, California, Colorado, Florida, Illinois, Michigan, Minnesota, Missouri
2017-08-15
Active, closed
A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease
NCT03251118Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis, Indeterminate Colitis
Target PharmaSolutions, Inc.
Observational
15,000
California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa, Louisiana
2017-07-24
Active, closed
ADAPT - A Patient Registry of the Real-world Use of Orenitram®
NCT03045029Pulmonary Arterial Hypertension
DrugTreprostinil
United Therapeutics
Observational
300
California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa, Kentucky
2017-07-18
Active, closed
LimiFlex Clinical Trial for the Treatment of Degenerative Spondylolisthesis With Spinal Stenosis
NCT03115983Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
Empirical Spine, Inc.
Not applicable
299
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Kentucky
2017-07-17
Active, closed
Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
NCT03155997Breast Cancer
DrugAbemaciclib
Eli Lilly and Company
Phase 3
5,637
Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Florida
2017-07-12
Active, closed
EARLY TAVR: Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis
NCT03042104Heart Diseases, Aortic Stenosis, Severe
Edwards Lifesciences
Not applicable
901
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Illinois
2017-07-12
Active, closed
A Study of Infuse® Bone Graft With Mastergraft® Strip and Posterior Fixation for Posterolateral Fusion (PLF) Treatment of Multi-Level Degenerative Lumbosacral Spinal Conditions
NCT03118505Multi-Level Degenerative Lumbosacral Spinal Conditions
Medtronic Spinal and Biologics
Not applicable
100
California, Colorado, Florida, Georgia, Indiana, Kansas, Michigan, New York
2017-06-29
Active, closed
A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease
NCT03100149Parkinson's Disease
DrugPrasinezumab
Hoffmann-La Roche
Phase 2
316
Alabama, Arizona, California, Colorado, Connecticut, Florida, Illinois, Kansas
2017-06-27
Active, closed
A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)
NCT03162536Lymphoma, B-Cell, Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia
DrugNemtabrutinib
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
Phase 1/2
190
Arizona, California, Colorado, Michigan, Minnesota, North Carolina, Ohio, Tennessee
2017-06-26
Active, closed
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
NCT03165734Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
DrugPacritinib
Swedish Orphan Biovitrum
Phase 3
407
Alabama, Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Illinois
2017-06-26
Active, closed
QUILT-3.032: A Multicenter Clinical Trial of Intravesical Bacillus Calmette-Guerin (BCG) in Combination With ALT-803 (N-803) in Patients With BCG Unresponsive High Grade Non-Muscle Invasive Bladder Cancer
NCT03022825Bladder Cancer
ImmunityBio, Inc.
Phase 2/3
190
Alaska, Arkansas, California, Colorado, Florida, Georgia, Hawaii, Illinois
2017-06-02
Active, closed
ATTUNE Revision System in the Revision Total Knee Arthroplasty Population
NCT03153475Revision Total Knee Arthroplasty
DePuy Orthopaedics
Not applicable
400
California, Colorado, Connecticut, Florida, Kentucky, Mississippi, Missouri, New Hampshire
2017-05-30
Active, closed
Dose Escalation Study of Teclistamab, a Humanized BCMA*CD3 Bispecific Antibody, in Participants With Relapsed or Refractory Multiple Myeloma
NCT03145181Hematological Malignancies
DrugTeclistamab
Janssen Research & Development, LLC
Phase 1
302
California, Colorado, New York, North Carolina, Pennsylvania
2017-05-16
Active, closed
Xeltis Bioabsorbable Pulmonary Valved Conduit Pivotal Study
NCT03022708Heart Defect, Congenital
Xeltis
Not applicable
6
California, Colorado, Florida, New York, Ohio, Pennsylvania, Texas
2017-05-08
Active, closed
A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)
NCT03157128Non-Small Cell Lung Cancer, Medullary Thyroid Cancer, Colon Cancer, Any Solid Tumor
DrugSelpercatinib
Eli Lilly and Company
Phase 1/2
857
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Louisiana
2017-05-02
Recruiting
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
NCT03053193Breast Cancer
Agendia
Observational
30,000
Alabama, Alaska, Arizona, California, Colorado, Connecticut, Delaware, Florida
2017-04-28
Active, closed
Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial
NCT03108456Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction
Abbott Medical Devices
Not applicable
2,005
Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida
2017-03-27
Recruiting
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
NCT03072927Lumbar Spinal Stenosis
Stryker Instruments
Observational
8,000
Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware
2017-03-10
Recruiting
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
NCT03093116Locally Advanced Solid Tumors, Metastatic Solid Tumors
DrugRepotrectinib
Turning Point Therapeutics, Inc.
Phase 1/2
500
California, Colorado, District of Columbia, Florida, Georgia, Illinois, Louisiana, Maryland
2017-03-07
Active, closed
Study of Vimseltinib (DCC-3014) in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor
NCT03069469Advanced Malignant Neoplasm, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor
DrugVimseltinib
Deciphera Pharmaceuticals, LLC
Phase 1/2
120
California, Colorado, Florida, Massachusetts, New York, Oregon, Tennessee
2017-02-16
Active, closed
Persona Partial Knee Clinical Outcomes Study
NCT03034811Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Conditional Tibial Condyle or Plateau Fractures
Zimmer Biomet
Not applicable
757
California, Colorado, Illinois, Indiana, Massachusetts, Michigan, New Mexico, South Carolina
2017-02-08
Active, closed
A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)
NCT03006068Ulcerative Colitis (UC)
DrugUpadacitinib
AbbVie
Phase 3
950
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2017-01-31
Recruiting
PARTNER 3 Trial - Aortic Valve-in-Valve
NCT03003299Aortic Stenosis, Aortic Stenosis, Severe
Edwards Lifesciences
Not applicable
125
Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Louisiana
2017-01-05
Active, closed
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
NCT02960022Prostate Cancer
DrugsLeuprolide Acetate·Xtandi·Abiraterone acetate·Enzalutamide
Astellas Pharma Global Development, Inc.
Phase 2
900
Alaska, Arizona, California, Colorado, District of Columbia, Florida, Illinois, Indiana
2016-12-22
Active, closed
A Study of Abemaciclib (LY2835219) in Participants With Non-Small Cell Lung Cancer or Breast Cancer
NCT02779751Non Small Cell Lung Cancer, Breast Cancer
DrugsAnastrozole·Abemaciclib·Pembrolizumab
Eli Lilly and Company
Phase 1
100
Arkansas, California, Colorado, Massachusetts, Michigan, New York
2016-11-14
Active, closed
Study of Tenofovir Alafenamide (TAF) in Children and Teen Participants With Chronic Hepatitis B Virus Infection
NCT02932150Chronic Hepatitis B
Gilead Sciences
Phase 2
150
California, Colorado, Indiana, Maryland, Missouri, New York, Ohio, Tennessee
2016-11
Active, closed
A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
NCT02951598Alzheimer Disease, Mild Cognitive Impairment
Eli Lilly and Company
Observational
1,400
California, Colorado, Connecticut, Florida, Georgia, Indiana, Kansas, Kentucky
2016-10-29
Active, closed
Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Long-acting Cabotegravir Plus Long-acting Rilpivirine From Current Antiretroviral Regimen in Virologically Suppressed HIV-1-infected Adults
NCT02951052Infection, Human Immunodeficiency Virus, HIV Infections
Drugs2 NRTIs·Cabotegravir (CAB)·Rilpivirine (RPV)·Rilpivirine
ViiV Healthcare
Phase 3
618
Alabama, Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois
2016-10-28
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Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 7 October 2026. https://priyalifescience.com/clinical-trials-usa/state/colorado?page=4

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,122 studies in total at the last sync on 07 Oct 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 2,073 of those studies with a site in Colorado.

How many clinical trials are recruiting in Colorado?

1,023 of the 2,073 studies on this page are recruiting new participants as of the 07 Oct 2026, 03:16 UTC sync. A further 24 have not yet opened recruitment, 960 are active but closed to new participants, and 66 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.