Avutometinib and sotorasib and defactinib is named as an intervention in 3 current clinical trials in our UK, USA, France, Spain, Netherlands, Belgium, Japan and Australia registers. 1 is recruiting patients now. The most common phase is Phase 1/2. The sponsor with the most trials is Verastem, Inc (2). The most-studied condition is Non Small Cell Lung Cancer.
| Study | Phase | Status | Lead sponsor | Registers |
|---|---|---|---|---|
|
Combined Evaluation of Epigenetic and Sensitising Therapy in AML and MDS
NCT05636514 · ClinicalTrials.gov ↗ · Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, Acute Myeloid Leukemia
|
Phase 1 | Recruiting | Clinical Hub for Interventional Research (CHOIR) | Australia |
|
A Study of Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer in Japanese Patients
NCT06682572 · ClinicalTrials.gov ↗ · Low Grade Serous Ovarian Cancer, Ovarian Cancer
|
Phase 2 | Active, closed | Verastem, Inc | Japan |
|
Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients
NCT05074810 · ClinicalTrials.gov ↗ · Non Small Cell Lung Cancer, KRAS Activating Mutation
|
Phase 1/2 | Active, closed | Verastem, Inc | UK, USA, France, Spain, Netherlands, Belgium |
Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
| Lead sponsor | Trials |
|---|---|
| Verastem, Inc | 2 |
| Clinical Hub for Interventional Research (CHOIR) | 1 |
A trial with sites in more than one country appears in each of those registers.
3 current trials in our UK, USA, France, Spain, Netherlands, Belgium, Japan and Australia registers name Avutometinib and sotorasib and defactinib (also registered as VS-6063) as a drug or biological intervention, as of the registry sync on 29 September 2026. Completed and withdrawn studies are not counted.
Yes. 1 of the 3 trials is recruiting: 1 with sites in Australia. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Verastem, Inc (2) and Clinical Hub for Interventional Research (CHOIR) (1). The number in brackets is how many trials each organisation leads.
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Avutometinib and sotorasib and defactinib works or whether it is effective, and it is not medical advice.
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Avutometinib and sotorasib and defactinib works or whether it is effective. Each trial links to its own record so you can check it yourself.
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Avutometinib and sotorasib and defactinib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 29 Sep 2026.