Clinical trial register · Italy

Clinical Trials in Milan, 2026

Every study on the ClinicalTrials.gov registry that lists a site in Italy and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 6791 matching records held by the registry are in this view. Synced 11 Oct 2026, 03:19 UTC

6791

Studies in scope

all four open statuses

4079

Recruiting now

open to new participants

1019

Lead sponsors

across recruiting studies

Top sites

Milan 2846 Bologna 1303 Roma 1272 Naples 983 Rome 968

Trials with a site in Milan

Status

Study

Lead sponsor

Phase

Enrol

Sites in Italy

Start

Not yet open

Implantable Loop Recorder and Cardioneuroblation

NCT07162740Reflex Syncope

Istituto Auxologico Italiano

Observational

Milan

2025-10-01

Not yet open

Improving Hand Movement and Coordination in People With Multiple Sclerosis Using Transcranial Magnetic Stimulation (TMS) and Muscle Electrostimulation (FES) To Support Manual Dexterity and Daily Function

NCT07098273Multiple Sclerosis

Fondazione Don Carlo Gnocchi ETS

Not applicable

Genova, Milan

2025-10

Recruiting

Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer

NCT07022483Endometrial Cancer

DrugTrastuzumab deruxtecan

Daiichi Sankyo

Phase 3

710

Bari, Bologna, Florence, Lecco, Milan, Torino

2025-09-30

Recruiting

Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy

NCT07106762Urothelial Cancer

DrugsIza-bren·Gemcitabine·Cisplatin·Carboplatin

Bristol-Myers Squibb

Phase 2/3

470

Bari, Genoa, Rome, Pisa, Castelfranco Veneto, Milan, Naples, Parma

2025-09-30

Recruiting

An Extension Trial to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy

NCT07197866Multiple System Atrophy

DrugEmrusolmin

Teva Branded Pharmaceutical Products R&D LLC

Phase 2

200

Bologna, Catania, Milan, Padova, Roma, Salerno

2025-09-30

Not yet open

Prospective Observational Analysis of Circulating Endocan Levels in Patients Presenting With Acute Diverticulitis

NCT07027007Diverticulitis

IRCCS Ospedale San Raffaele

Observational

Milan

2025-09-30

Not yet open

LUpus Eritematoso Sistemico NETwork and Registry

NCT07175610Systemic Lupus Erythematous (SLE)

Società Italiana di Allergologia, Asma e Immunologia Clinica

Observational

1,500

Ancona, Bari, Battipaglia, Cagliari, Florence, Mantua, Milan, Naples

2025-09-30

Recruiting

A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis

NCT06865417Ulcerative Colitis

DrugFilgotinib

Alfasigma S.p.A.

Phase 3

Alessandria, Ancona, Milan, Naples, Rome, Trieste

2025-09-29

Recruiting

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

NCT06979336Ulcerative Colitis

Genentech, Inc.

Phase 2

224

Rome, Brescia, Milan, Rho, Rozzano, San Donato Milanese (MI), Turin, Negrar

2025-09-29

Recruiting

Use of Cryopressotherapy in Patiens Undergoing Total Knee Replacement to Improve Clinical Outcome

NCT07456787Total Knee Arthroplasty\(TKA\), Osteoartrosi

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Not applicable

Milan

2025-09-29

Recruiting

Breast Cancer RElapsed in Patients Treated With Adjuvant CDK4/6 Inhibitors:

NCT07180693Adjuvant Therapy, CDK4/6 Inhibitor

European Institute of Oncology

Observational

750

Bergamo, Brescia, Brindisi, Crema, Lecco, Legnano, Milan, Modena

2025-09-29

Recruiting

Assess Abdominal Aortic Diameter in Females

NCT07487961Aorta Disease, Aorta Aneurysm

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Observational

652

Milan

2025-09-29

Recruiting

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

NCT07028853Metastatic Castration Sensitive Prostate Cancer (mCSPC), Hormone Sensitive Prostate Cancer, Prostate Cancer, Cancer of the Prostate

DrugsMevrometostat·Xtandi·Enzalutamide

Pfizer

Phase 3

1,000

Meldola, Ravenna, Rozzano, Orbassano, Rome, Milan, Novara, Padova

2025-09-28

Recruiting

Targeted Decision Making In Renal Cell Carcinoma Relying on a Radiogenomics Translational Platform

NCT06868927Renal Tumors

IRCCS San Raffaele

Observational

Milan

2025-09-26

Recruiting

A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease

NCT07190196Immunoglobulin G4 Related Disease

DrugRilzabrutinib

Sanofi

Phase 3

124

Florence, Milan, Verona

2025-09-26

Recruiting

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

NCT07102381HER2-positive Breast Cancer, Breast Cancer

DrugsZanidatamab·Pertuzumab·Trastuzumab·Docetaxel

Jazz Pharmaceuticals

Phase 2

125

Milan, Bologna, Genoa, Misterbianco, Monza

2025-09-24

Recruiting

A Phase I/II Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma

NCT07123454B-cell Non-Hodgkin Lymphoma

AstraZeneca

Phase 1/2

Bologna, Milan

2025-09-24

Recruiting

An Innovative Cognitive-Behavioral Treatment For Chronic Orofacial Pain

NCT07123233Chronic Primary Orofacial Pain (CPOP), Persistent Idiopathic Facial Pain (PIFP)

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Not applicable

Milan

2025-09-24

Recruiting

A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

NCT07111520Non-small Cell Lung Cancer

DrugsBNT326·Pumitamig

BioNTech SE

Phase 1/2

880

Alessandria, Catania, Florence, Milan, Roma

2025-09-22

Recruiting

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

NCT07181109High Risk Cardiovascular Disease, Hypertension, High Cardiovascular Risk

DrugZilebesiran

Alnylam Pharmaceuticals

Phase 3

11,000

Ancona, Cittadella, Lecco, L’Aquila, Messina, Milan, Naples, Novara

2025-09-22

Recruiting

Study of ALXN1920 in Adult Participants With Primary Membranous Nephropathy (PMN)

NCT07157787Primary Membranous Nephropathy

Alexion Pharmaceuticals, Inc.

Phase 2

Milan, Ranica, Torrette

2025-09-19

Recruiting

A New Portable Device for Non-invasive Ventilatory Support

NCT06716502Healthy, Respiratory Disease

Università Vita-Salute San Raffaele

Not applicable

Lecce, Milan, Verona

2025-09-17

Active, closed

A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

NCT07169578Alzheimers Disease

DrugTrontinemab

Hoffmann-La Roche

Phase 3

1,101

Rome, Genoa, Brescia, Milan

2025-09-17

Recruiting

Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis

NCT07023835Amyotrophic Lateral Sclerosis (ALS)

Zydus Therapeutics Inc.

Phase 2

240

Genova, Milan, Modena, Naples, Brescia

2025-09-17

Recruiting

Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)

NCT07176689Desmoid Tumor, Aggressive Fibromatosis

DrugNirogacestat

SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Phase 4

Meldola, Candiolo, Bologna, Milan, Naples, Roma

2025-09-17

By invitation

ACTG2/FLNA Testing Yield in Adult Idiopathic Chronic Intestinal Pseudo-Obstruction (CIPO) With Reduced/Absent Distal Esophageal Contractility

NCT07448753Pseudo Obstruction

Marina Coletta

Observational

Milan

2025-09-17

Recruiting

A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP

NCT07091630Chronic Inflammatory Demyelinating Polyneuropathy, CIDP, Chronic Inflammatory Demyelinating Polyradiculoneuropathy

DrugEmpasiprubart

argenx

Phase 3

160

Gussago, Trieste, Bologna, Genova, Milan, Pavia

2025-09-16

Recruiting

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype

NCT07190209Chronic Obstructive Pulmonary Disease

DrugLunsekimig

Sanofi

Phase 3

942

Milan, Rozzano, Padova, Pavia, Reggio Emilia, Tradate (Va)

2025-09-16

Active, closed

Optimization of Oocyte Warming Protocols

NCT07105891Oocyte Cryopreservation

IRCCS San Raffaele

Not applicable

399

Milan

2025-09-16

Recruiting

Natural History and Genotype-Phenotype Correlations in Mitochondrial Leukoencephalopathies

NCT07868796Mitochondrial, Leukoencephalopathies, Leukoencephalopathy

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Observational

100

Milan

2025-09-15

Recruiting

Comparison of Maglumi X3 SNIBE With Other Analytical Methods in Laboratory Medicine for 25-(OH)D Quantification

NCT07337499Quantification of 25-(OH)D in Physiological Condition

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Observational

200

Milan

2025-09-15

Recruiting

Cardiac Assessment for Thrombus Detection in the Heart Using Advanced Imaging (MRI, CT) in ESUS With Left Ventricular Disease

NCT07298122Cryptogenic Ischemic Stroke

Niguarda Hospital

Observational

125

Milan

2025-09-15

Recruiting

A Study to Evaluate How Apitegromab Works in Subjects Who Are Less Than 2 Years Old and Have Spinal Muscular Atrophy

NCT07047144Spinal Muscular Atrophy, SMA, Spinal Muscular Atrophy Type 2, Spinal Muscular Atrophy Type 3

DrugsApitegromab·Nusinersen·Risdiplam

Scholar Rock, Inc.

Phase 2

Milan, Rome

2025-09-15

Recruiting

Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial

NCT07203911Tongue Cancer, Oral Cancer, Squamous Cell Carcinoma of the Oral Cavity or Oropharynx

Tobias Todsen

Not applicable

150

Milan

2025-09-15

Recruiting

Intent of Surgery for IPMN

NCT07216521Intraductal Papillary Mucinous Neoplasm

NYU Langone Health

Observational

2,000

Milan, Padua

2025-09-15

Active, closed

A Study to Test Whether Nerandomilast Helps People With Lung Fibrosis Related to Rheumatic Diseases

NCT06806592Interstitial Lung Diseases, Systemic Autoimmune Rheumatic Diseases Associated Interstitial Lung Diseases

DrugNerandomilast

Boehringer Ingelheim

Phase 3

413

Brescia, Florence, Milan, Padova, Pavia, Roma

2025-09-13

Recruiting

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

NCT06926868Breast Neoplasms

DrugsIza-bren·Nab-paclitaxel·Capecitabine·Gemcitabine

Bristol-Myers Squibb

Phase 2/3

600

Naples, Bologna, Aviano, Genoa, Pontedera, Prato, Milan, Novara

2025-09-11

Recruiting

A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants With High Risk Non-Muscle-Invasive Bladder Cancer

NCT06919965Non-Muscle Invasive Bladder Neoplasms

DrugsErdafitinib·Mitomycin C·Gemcitabine

Janssen Research & Development, LLC

Phase 3

220

Bergamo, Brescia, Genova, Milan, Naples, Roma, Sanatorio San Luigi, Udine

2025-09-10

Recruiting

Study to Assess Change in Quality of Life of Risankizumab Treatment in Adult Participants With Moderate-to-Severe Plaque Psoriasis

NCT07039110Plaque Psoriasis

AbbVie

Observational

700

L’Aquila, Milan, Naples, Rome, Genova

2025-09-09

Recruiting

A Study of Navlimetostat (BMS-986504) Alone or in Combination With Izalontamab Brengitecan in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion or MTAP Loss (MountainTAP-9)

NCT06855771Carcinoma, Non-Small-Cell Lung

DrugsNavlimetostat·Iza-bren

Bristol-Myers Squibb

Phase 2

182

Naples, Monza, Milan, Padova, Bologna

2025-09-09

Recruiting

Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

NCT07011719Metastatic Clear Cell Renal Cell Carcinoma, Advanced Clear Cell Renal Cell Carcinoma

DrugsCasdatifan·Cabozantinib

Arcus Biosciences, Inc.

Phase 3

720

Florence, Genova, Milan, Naples, Padua, Perugia, Rome, Rozzano

2025-09-08

Recruiting

A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT06973187Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsTacabrutideg·Pirtobrutinib

BeOne Medicines

Phase 3

500

Bologna, Milan, Padova

2025-09-04

Recruiting

A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)

NCT07164443Metastatic Castration-resistant Prostatic Neoplasms

DrugsJNJ-87189401·Pasritamig

Janssen Research & Development, LLC

Phase 3

1,203

Foggia, Milan, Naples, Padova, Palermo, Roma, Rozzano, Torino

2025-09-02

Recruiting

Clinical Trial on Bowel Preparation Comparing Mannitol 100g to Plenvu Both in a Same Day Regimen (CLEARWAY)

NCT07465705Elective Colonoscopy

DrugMannitol

NTC srl

Phase 3

412

Carpi, Aviano, Negrar, Bologna, Brescia, Como, Milan, Roma

2025-09-02

Recruiting

A Study to Investigate the Efficacy and Safety of Rilzabrutinib in Adult Participants With Graves' Disease

NCT06984627Graves' Disease

DrugRilzabrutinib

Sanofi

Phase 2

Milan, Merano, Palermo, Pisa

2025-09-02

Recruiting

Neuropsychological Profile Characterization in Patients With Migraine: Cognitive Functioning and Psychological Variables

NCT07233941Migraine, Migraine Disease

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Observational

150

Milan

2025-09-01

Recruiting

Atropine Eyedrops for Myopia Progression in Children and Adolescents (MODERATO STUDY)

NCT07028827Myopia

DrugAtropine eye

Ocus Innovation Ireland Limited

Phase 3

234

Bari, Milan, Padua

2025-09-01

Active, closed

Artificial Intelligence Assisting Transcatheter Mitral Edge-to-Edge Repair

NCT07632794Mitral Regurgitation

Mi Chen

Observational

1,500

Milan

2025-09-01

Recruiting

Insights From the FAST-TRACK CABG Trial: a Clinical Outcome Study in Patient With Previous Surgical Revascularization for Complex Three-vessel or Left Main Coronary Artery Disease Based on Coronary Computed Tomography Angiogram, and Fractional Flow Reserve Derived by Computed Tomography

NCT07628270Multivessel Coronary Artery Disease

Centro Cardiologico Monzino

Observational

100

Milan

2025-09-01

Not yet open

Telerehabilitation in Central and Peripheral Neurological Sequelae From Chemotherapy

NCT07159854Chemotherapy-induced Neurotoxicity

Fondazione Don Carlo Gnocchi ETS

Not applicable

Milan

2025-09-01

Recruiting

DEFINITION OF THE GENOMIC LANDSCAPE OF MASLD

NCT07249112Cirrhosis, MASLD

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Not applicable

2,880

Milan

2025-09-01

Not yet open

Vagal Nerve Stimulation to Treat Disorders of Consciousness

NCT07077135Disorder of Consciousness

Fondazione IRCCS San Gerardo dei Tintori

Not applicable

106

Brescia, Monza, Bergamo, Como, Genova, Milan, Padova, Parma

2025-09-01

Recruiting

Single-center Transversal Observational Study on the Evaluation of S100B Changes in Subjects Attending the Emergency Department With Head Trauma

NCT07036146Head Trauma

IRCCS San Raffaele

Observational

1,000

Milan

2025-09-01

Not yet open

VCV vs PRVC in Pediatric Anesthesia; an EIT- and LS-based Study

NCT07182539Atelectasis

Vittore Buzzi Children's Hospital

Not applicable

Milan

2025-09

Not yet open

Metabolic Risk Assessment in Prepubertal Children With Congenital Hypothyroidism

NCT07126353Congenital Hypothyroidism, Metabolic Syndrome

Buzzi Children's Hospital

Observational

170

Milan

2025-09

Not yet open

5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemotherapy With Advanced Unresectab

NCT07124884Colorectal Carcinoma, KRAS G12C Mutation, Unresectable Colorectal Cancer

Federation Francophone de Cancerologie Digestive

Phase 2

300

Aviano, Catania, Florence, Livorno, Meldola, Milan, Monserrato, Padova

2025-08-31

Recruiting

MicroRNA and Markers and Therapeutic Response to Romosozumab and Abaloparatide in Postmenopausal Osteoporosis

NCT07616401Osteoporosis, Menopause

Istituto Auxologico Italiano

Not applicable

Miano, Milan

2025-08-31

Recruiting

A Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon 45 Skipping to Evaluate the Safety and Efficacy of ENTR-601-45

NCT07038824Duchenne Muscular Dystrophy (DMD)

DrugENTR-601-45

Entrada Therapeutics, Inc.

Phase 1/2

Milan, Rome

2025-08-30

Active, closed

A Research Study to See How Insulin Icodec Helps People With Type 1 Diabetes Control Their Blood Sugar

NCT07160816Diabetes Mellitus, Type 1

DrugInsulin icodec

Novo Nordisk A/S

Observational

245

Milan, Turin, Livorno, Lucca, Bergamo, Catanzaro, Naples, Perugia

2025-08-28

Recruiting

A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

NCT07043400Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

DrugsLeucovorin·Adrucil·Tislelizumab·Capecitabine

BeOne Medicines

Phase 3

351

Genova, Milan, Pisa, Rozzano

2025-08-27

Recruiting

A Trial Evaluating Brelovitug (BJT-778) vs Bulevirtide for the Treatment of Chronic Hepatitis Delta Infection (AZURE-2)

NCT07200908Chronic Hepatitis D Infection

DrugBulevirtide

Mirum Pharmaceuticals, Inc.

Phase 3

172

Bergamo, Milan, Parma, Pisa, Roma

2025-08-27

Recruiting

A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors

NCT07169734Cervical Squamous Cell Carcinoma, Squamous Non-small-cell Lung Cancer, Colorectal Cancer, Intrahepatic Cholangiocarcinoma

Alentis Therapeutics AG

Phase 1/2

180

Milan, Ravenna, Rossano, Siena

2025-08-26

Recruiting

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

NCT06982521PIK3CA Mutation, HER2- Negative Breast Cancer, Hormone Receptor Positive Tumor, Breast Cancer

DrugsCapivasertib·Fulvestrant

Relay Therapeutics, Inc.

Phase 3

540

Ancona, Brescia, Candiolo, Cona, Florence, Livorno, Meldola, Milan

2025-08-26

Recruiting

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.

NCT06925321Invasive Mold Infections

DrugFosmanogepix

Basilea Pharmaceutica

Phase 3

234

Genova, Milan, Modena, Pavia, Pisa, Trieste

2025-08-26

Recruiting

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine

NCT07018700Episodic Migraine

DrugXeomin

Merz Therapeutics GmbH

Phase 3

990

Florence, Milan, Pavia, Roma

2025-08-21

Recruiting

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

NCT07018713Chronic Migraine

DrugXeomin

Merz Therapeutics GmbH

Phase 3

780

Florence, Milan, Pavia, Roma

2025-08-21

Recruiting

A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer

NCT07005154Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer, Metastatic Hormone Sensitive Prostate Cancer

DrugsPRL-02·Abiraterone acetate·Prednisolone·Prednisone

Astellas Pharma Global Development, Inc.

Phase 2

218

Milan, Roma, Trento

2025-08-19

Recruiting

A Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Oral Rilzabrutinib Compared With Placebo in Participants 18 Years of Age and Older With Warm Autoimmune Hemolytic Anemia

NCT07086976Autoimmune Haemolytic Anaemia

DrugRilzabrutinib

Sanofi

Phase 3

Florence, Genoa, Milan, Naples, Meldola, Novara, Palermo, Trieste

2025-08-18

Active, closed

A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

NCT07005128Small-cell Lung Cancer, Extensive Stage Small-cell Lung Cancer

DrugsTarlatamab·Etoposide·Durvalumab·Carboplatin

Amgen

Phase 3

350

Bari, Bergamo, Meldola (FC), Milan, Roma, Verona

2025-08-18

Active, closed

An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)

NCT06961344Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)

Tisento Therapeutics

Phase 2

Milan, Rome

2025-08-18

Recruiting

A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

NCT07196501Major Depressive Disorder

DrugNBI-1065845

Neurocrine Biosciences

Phase 3

550

Milan, Roma, Rome, Torino

2025-08-18

Recruiting

A Research Study to See How Well Weekly Insulin Icodec Maintains Blood Sugar Levels Compared to Daily Basal Insulins in Adults With Type 2 Diabetes

NCT07112339Diabetes Mellitus, Type 2

DrugInsulin icodec

Novo Nordisk A/S

Phase 4

586

Bari, Catanzaro, Naples, Rome, Milan, Messina, Palermo, Fermo

2025-08-15

Recruiting

A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

NCT06948318Immune Thrombocytopenic Purpura (ITP)

DrugMezagitamab

Takeda

Phase 3

150

Naples, Rome, Catania, Bologna, Milan, Monza, Novara, Torino

2025-08-14

Recruiting

A Study of Barrett's Esophagus Patients to Investigate Quality of Life and Fear of Cancer, and Optimize a Risk Model Based on Biomarkers and New Technologies to Better Predict the Development of Cancer

NCT06523374Barrett's Esophagus, Esophageal Adenocarcinoma

University Hospital, Antwerp

Not applicable

Milan

2025-08-13

Recruiting

Observational, Prospective, Multi-centric Study Exploring HER2 Mutations Incidence and Therapeutic Management in aNSCLC

NCT07356544NSCLC (Advanced Non-small Cell Lung Cancer), HER2

Gruppo Oncologico Italiano di Ricerca Clinica

Observational

Bari, Meldola, Ferrara, Genova, Lido di Camaiore, Lucca, Monza, Milan

2025-08-12

Recruiting

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

NCT07070232Advanced Solid Tumor

DrugsBNT326·Paroxetine·Itraconazole·Pumitamig

BioNTech SE

Phase 1/2

1,438

Meldola, Milan, Naples, Roma, Rozzano

2025-08-12

Recruiting

The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease

NCT06975865Sickle Cell Disease

DrugRilzabrutinib

Sanofi

Phase 3

192

Florence, Milan, Naples, Rome, Orbassano, Palermo, Verona

2025-08-12

Recruiting

ItAlian ReGistry Of pNeumoniA in immUnocompromised paTients (ARGONAUT)

NCT06755814Community Acquired Pneumonia (CAP)

Societa Italiana di Pneumologia

Observational

1,298

Milan

2025-08-11

Active, closed

Ultra-Safe Hormonal Strategy: Transdermal Estradiol Added to Progestins for Endometriosis

NCT07204093Endometriosis

DrugsDienogest·Drospirenone

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Observational

138

Milan

2025-08-11

Recruiting

Focused Orticumab Research for Treating Inflammation in Coronary Arteries

NCT06927739Acute Coronary Syndromes, Coronary Arterial Disease (CAD), Inflammation, Heart Disease

Abcentra

Phase 2

240

Caserta, Ferrara, Brescia, Milan, Pavia

2025-08-11

Recruiting

A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC) [EMBOLD SCLC-301]

NCT07099898Neoplasms, Lung

DrugsRis-Rez·Risvutatug rezetecan·Topotecan

GlaxoSmithKline

Phase 3

420

Milan, Bergamo, Genova, Orbassano, Pisa, Siena, Verona

2025-08-11

Recruiting

A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

NCT07098338Non-Small Cell Lung Cancer

DrugsRamucirumab·Rilvegostomig·Dato-DXd

AstraZeneca

Phase 2

278

Aviano, Catania, Meldola, Milan, Orbassano, Roma, Rozzano

2025-08-07

Recruiting

A Study to Assess Efficacy and Safety of Baxdrostat in Participants With Primary Aldosteronism

NCT07007793Primary Hyperaldosteronism

DrugBaxdrostat

AstraZeneca

Phase 3

250

Bologna, Brescia, Florence, Milan, Torino

2025-08-07

Recruiting

Phase II Study of Radiotherapy Followed by Durvalumab and Ceralasertib in Stage III NSCLC Patients With Thoracic Relapses +/- Oligometastases After PACIFIC Regimen

NCT06680050Non Small Cell Lung Cancer NSCLC

DrugsCeralasertib·Durvalumab

Mario Negri Institute for Pharmacological Research

Phase 2

Brescia, Florence, Genova, Milan, Padova, Parma

2025-08-07

Recruiting

A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes

NCT07088068Type 1 Diabetes Mellitus

DrugsTzield·Teplizumab

Sanofi

Phase 3

723

Florence, Genoa, Milan, Rome, Turin, Bologna, Messina, Novara

2025-08-06

Active, closed

A Study Evaluating Persistence of the Immune Response of the Adjuvanted Respiratory Syncytial Virus (RSV) Vaccine and the Safety and Immune Response Following Revaccination in Adults 18 Years of Age and Above Who Received Lung or Kidney Transplant

NCT07092865Respiratory Syncytial Virus Infections

GlaxoSmithKline

Phase 2

168

Milan, Palermo, Pavia, Siena

2025-08-06

Recruiting

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

NCT06952803Prostate Cancer

DrugsPrednisolone/prednisone·Saruparib·Abiraterone

AstraZeneca

Phase 3

700

Arezzo, Bari, Bergamo, Chieti, Genoa, Milan, Naples, Palermo

2025-08-06

Recruiting

Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO)

NCT06709339Polypoidal Choroidal Vasculopathy

DrugsVabysmo·Faricimab

Association for Innovation and Biomedical Research on Light and Image

Phase 4

120

Milan, Novara, Roma, San Raffaele, Udine

2025-08-06

Recruiting

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

NCT07062965Breast Cancer

DrugsPrifetrastat·Exemestane·Everolimus·Fulvestrant

Pfizer

Phase 3

400

Bologna, Meldola, Naples, Milan

2025-08-05

Recruiting

Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy

NCT07075016Acute Myeloid Leukemia

Stichting Hemato-Oncologie voor Volwassenen Nederland

Phase 3

227

Bologna, Milan, Roma, Torino

2025-08-05

Recruiting

Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease

NCT06607458Refractory Metastatic Colorectal Cancer

DrugsMelphalan·Trifluridine/Tipiracil·Bevacizumab

Delcath Systems Inc.

Phase 2

Milan

2025-08-05

Recruiting

MELAFERT: Impact of Adjuvant Therapy on FERTility in Patients With Resected MELAnoma at High Risk of Relapse.

NCT07092670Melanoma, Fertility

DrugsDabrafenib·Trametinib·Nivolumab·Pembrolizumab

Intergruppo Melanoma Italiano

Observational

270

Bari, Genova, Milan, Modena, Naples, Padova, Perugia, Roma

2025-08-04

Recruiting

CACP: Study on Camptodactyly - Arthropathy - Coxa Vara - Pericarditis (CACP) Syndrome

NCT07468461Camptodactyly, Arthropathy, Coxa Vara, Pericarditis

Meyer Children's Hospital IRCCS

Observational

Bari, Florence, Genova, Milan, Padova, Roma, Udine

2025-08-01

Recruiting

DCB vs. DES in Bifurcation Coronary Lesions

NCT06551662Coronary Artery Disease, DCB

Fondazione Ricerca e Innovazione Cardiovascolare ETS

Not applicable

321

Milan

2025-08-01

Recruiting

HOPE Against Cancer Recurrence in HCC

NCT06717919Liver Transplantation, HCC, Oncological Outcomes

Philipp Dutkowski

Phase 4

220

Milan, Padova, Rome, Udine

2025-08-01

Recruiting

Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

NCT07044336Endometrial Cancer, Malignant Solid Tumour

DrugsAdriamycin·Taxol·Doxorubicin·Paclitaxel

AstraZeneca

Phase 3

800

Alessandria, Aviano, Bari, Bologna, Catania, Florence, Haifa, Milan

2025-08-01

Recruiting

Trial Investigating Visugromab in Combination With Immunochemotherapy in 1L Treatment of Participants With Metastatic NSCLC

NCT07098988Metastatic Non-Squamous Non-Small Cell Lung Cancer, Adult Solid Tumor

DrugsPemetrexed /m^2·Carboplatin (AUC 5)·Visugromab·Visugromab RDE

CatalYm GmbH

Phase 2

107

Meldola, Milan, Aviano, Ravenna, Rome

2025-08-01

Not yet open

Exploring the Relationship Between Social Expertise and Ability to Process Different Types of Abstract Concepts and the Neural Resources Allocated to Their Processing

NCT07112027Healthy

Università Vita-Salute San Raffaele

Not applicable

Milan

2025-08

Recruiting

AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

NCT07094113KRAS Altered Advanced or Metastatic Solid Tumors

DrugsPanitumumab·Pembrolizumab

Amgen

Phase 1

434

Milan, Pisa, Verona

2025-07-31

Recruiting

Toxicity Markers to Trastuzumab-Deruxtecan (T-DXd) In Patients With Advanced Breast Cancer

NCT07049133Metastatic Breast Cancer

European Institute of Oncology

Observational

Milan

2025-07-31

Recruiting

Characterization of the Natural History of LAMA2-RD and Identification of Novel Disease Biomarkers

NCT07125040LAMA2-MD (Merosin Deficient Congenital Muscular Dystrophy, MDC1A), LAMA2-MD \(Merosin Deficient Congenital Muscular Dystrophy, MDC1A\), Merosin Deficient CMD (Full or Partial), Merosin Deficient Congenital Muscular Dystrophy

Università Vita-Salute San Raffaele

Observational

Milan

2025-07-31

Recruiting

Early Ravulizumab Treatment Of Anti- AChR Antibody-Positive Generalized Myasthenia Gravis

NCT06967480Generalized Myasthenia Gravis, Anti-AChR Antibody Positive

DrugRavulizumab

Alexion Pharmaceuticals, Inc.

Observational

Bergamo, Bologna, Brescia, Florence, Imperia, Lecco, Messina, Milan

2025-07-31

Recruiting

Study of GS-4321 in Healthy Participants and Participants With Chronic Hepatitis Delta Virus

NCT07096193Chronic Hepatitis Delta

Gilead Sciences

Phase 1/2

200

Milan

2025-07-31

Recruiting

A Study of Pirtobrutinib in Participants With Immune Thrombocytopenia

NCT06721013Immune Thrombocytopenia (ITP)

DrugPirtobrutinib

Eli Lilly and Company

Phase 1/2

Bologna, Milan, Roma, Trieste

2025-07-30

Active, closed

A Study to Evaluate Tobevibart+Elebsiran in Participants With Chronic HDV Infection Not Virologically Suppressed With Bulevirtide

NCT07128550Viral Hepatitis

DrugsTobevibart·Elebsiran·Bulevirtide

Vir Biotechnology, Inc.

Phase 3

150

Bergamo, Foggia, Milan, Pisa, Torino

2025-07-30

Recruiting

Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)

NCT06780111Esophageal Squamous Cell Carcinoma

DrugsIfinatamab Deruxtecan·Sacituzumab tirumotecan·Leucovorin·Adrucil

Merck Sharp & Dohme LLC

Phase 1/2

298

Milan, Padova

2025-07-30

Recruiting

5 fr Ultrahypofractionated WBI and SIB for Breast Cancer With Unfavorable Characteristics

NCT07020780Breast Cancer

IRCCS San Raffaele

Not applicable

458

Milan

2025-07-25

Recruiting

Single-fraction APBI for Early-stage Breast Cancer With Favorable Histological Subtypes (Breast-1F)

NCT06946238Breast Cancer

IRCCS San Raffaele

Not applicable

311

Milan

2025-07-25

Recruiting

Phase 2/3 Study of Participants With Recurrent Pericarditis Evaluating the Efficacy and Safety of KPL-387

NCT07010159Pericarditis, Pericarditis Acute, Recurrent Pericarditis

DrugKPL-387

Kiniksa Pharmaceuticals International, plc

Phase 2/3

325

Florence, Genoa, Milan, Padua, Turin, Udine, Varese

2025-07-25

Recruiting

Omission of Local Therapies in Women Patients With HER2-positive or Triple-negative Breast Cancer

NCT06938724Breast Neoplasm Malignant Female

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Phase 2

152

Milan

2025-07-25

Recruiting

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

NCT07037433Atherosclerotic Cardiovascular Disease, Overweight, Obesity

DrugMaridebart cafraglutide

Amgen

Phase 3

12,800

Arzignano, Caserta, Ceccano, Chieti, Foggia, L’Aquila, Milan, Padova

2025-07-25

Recruiting

Patient Reported Outcome Measurements (PROMs) Impact on Clinical Outcome in firsT Line settIng Non- Small-Cell Lung Cancer (NSCLC) According to Chemo- Immunotherapy reGimen

NCT07061379PROMs

DrugsIvonescimab·Pemetrexed·Nivolumab

IRCCS San Raffaele

Observational

144

Milan

2025-07-24

Recruiting

Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

NCT06757634Breast Cancer

DrugsGedatolisib·Ribociclib·Palbociclib·Letrozole

Celcuity Inc

Phase 3

1,180

Fano, Genova, Meldola, Milan, Modena, Naples, Parma, Pavia

2025-07-24

Recruiting

A Muscle-brain Interplay Study in Neurological Disorders

NCT07477821Neurological Disorders, Health Adult Subjects

Istituti Clinici Scientifici Maugeri SpA

Observational

150

Catania, Messina, Milan, Roma

2025-07-24

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)

NCT06953960Multiple Myeloma

DrugsEtentamig·Pomalidomide·Daratumumab·Dexamethasone

AbbVie

Phase 1/2

325

Milan

2025-07-23

Recruiting

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

NCT07060807Breast Neoplasms

DrugsPatritumab deruxtecan·Pegylated liposomal doxorubicin·Abraxane·Xeloda

Merck Sharp & Dohme LLC

Phase 3

1,000

Bergamo, Milan, Naples, Roma

2025-07-21

Recruiting

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

NCT06943755Pancreatic Neuroendocrine Tumor (pNET), Extra-Pancreatic Neuroendocrine Tumor (epNET)

DrugsZanzalintinib·Everolimus

Exelixis

Phase 2/3

440

Aviano, Bologna, Meldola, Milan, Naples, Orbassano to, Palermo, Roma

2025-07-21

Recruiting

Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis

NCT06950385Familial Adenomatous Polyposis (FAP)

DrugERapa

Rapamycin Holdings Inc.

Phase 3

168

Milan

2025-07-18

Recruiting

A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

NCT06929273Bipolar Disorder Type I With Mania

DrugsValproate·Lamotrigine·Lithium·KarXT

Bristol-Myers Squibb

Phase 3

450

Milan, Pisa, Siena, Ancona, Genova

2025-07-18

Recruiting

A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma

NCT07069712Gastroesophageal Adenocarcinoma

DrugsSonesitatug Vedotin·Calcium folinate·Rilvegostomig·Trastuzumab deruxtecan

AstraZeneca

Phase 2

100

Florence, Milan, Modena, Pisa, Rozzano, Udine, Vicenza

2025-07-17

Recruiting

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

NCT06765109Non-small Cell Lung Cancer, Anaplastic Lymphoma Kinase-positive

DrugsNeladalkib·Alectinib

Nuvalent Inc.

Phase 3

450

Ancona, Bari, Meldola, Milan, Monza, Pisa, Ravenna, Roma

2025-07-17

Recruiting

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

NCT06997497Colon Adenocarcinoma, Rectal Adenocarcinoma

DrugsBevacizumab biosimilar·Calderasib·Mvasi·Erbitux

Merck Sharp & Dohme LLC

Phase 3

477

Monserrato, Milan, Naples, Padova, Ravenna, Verona

2025-07-16

Recruiting

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease

NCT07011745Alzheimer's Disease

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

426

Naples, Rome, Milan, Pisa, Brescia, Isernia, Roma

2025-07-16

Recruiting

A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

NCT06570798Systemic Lupus Erythematosus, Active Refractory Rheumatoid Arthritis

DrugsUplizna·Inebilizumab·Blinatumomab

Amgen

Phase 2

220

Milan, Rozzano, Turin

2025-07-16

Active, closed

A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)

NCT06963710Chronic Hepatitis B Infection

DrugALG-000184

Aligos Therapeutics

Phase 2

200

Milan

2025-07-15

Recruiting

Implantation of Engineered Cartilage Grafts for Treatment of Patellofemoral Osteoarthritis Versus Surgical Comparators.

NCT06576583Patellofemoral Osteoarthritis

DrugN-Tec

University Hospital, Basel, Switzerland

Phase 2

150

Milan, Rome

2025-07-15

Recruiting

A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice

NCT07284121Lung Cancer, Hepatocellular Carcinoma

DrugsTecentriq·Atezolizumab

Hoffmann-La Roche

Observational

700

Lecce, Naples, Modena, Ravenna, Rome, Genoa, Bergamo, Milan

2025-07-15

Recruiting

A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy

NCT06963827Kidney Disease

DrugMezagitamab

Takeda

Phase 3

347

Bologna, Brescia, Genoa, Messina, Milan, Pavia, Piacenza, Torino

2025-07-15

Active, closed

A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)

NCT07015983Lupus Erythematosus, Systemic, Lupus Nephritis

DrugsZola-cel·Fludarabine·Cyclophosphamide

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 2

Rome, Milan, Pisa

2025-07-14

Recruiting

A Study to Assess the Effectiveness of Second-Line Therapy of Upadacitinib and Risankizumab in Adult Participants With Crohn's Disease in a Real-World Setting

NCT07073079Crohn's Disease

AbbVie

Observational

250

Castellana Grotte, Monserrato, San Giovanni Rotondo, Rozzano, Milan, Monza, Naples, Turin

2025-07-14

Recruiting

Bronchoscopic Microwave Ablation of Lung Tissue in Surgical Candidates - UK

NCT06869122Lung Cancer

Creo Medical Limited

Observational

Milan

2025-07-14

Recruiting

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

NCT06976216Alzheimer's Disease

DrugsKarX-EC·KarXT

Bristol-Myers Squibb

Phase 3

586

Milan, Monza, Brescia

2025-07-14

Recruiting

Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

NCT06898515Acute Decompensated Heart Failure

DrugFurosemide

Reprieve Cardiovascular, Inc

Phase 3

400

Ancona, Bergamo, Milan

2025-07-14

Recruiting

The Predictive Value of Dobutamine Echo-stress in the Clinical Response to CCM Therapy in Advanced HF

NCT06973902Symptomatic Congestive Heart Failure

Quovadis Associazione

Observational

120

Marcianise, Mercogliano, Sessa Aurunca, Bologna, Anzio, Milan, Cefalù, Ascoli Piceno

2025-07-10

Recruiting

Ketamine Augmentation of ECT in Treatment-Resistant Depression

NCT07088380Major Depressive Disorder, Treatment Resistant Depression

DrugKetamine Hydrochloride

Università Vita-Salute San Raffaele

Phase 3

Milan

2025-07-10

Recruiting

Repurposing Mirtazapine in Rett Syndrome

NCT07430046RETT Syndrome With Proven MECP2 Mutation

DrugMirtazapine

University of Trieste

Phase 2

Genova, Messina, Milan, Siena

2025-07-09

Active, closed

Monocentric Pilot Study for the Application of an Endourethral Device for the Treatment of Stress Urinary Incontinence

NCT07327528Urinary Incontinence , Stress

Relief srl

Not applicable

Milan

2025-07-09

Active, closed

REal-life ON PARKinson's - ITaly (REONPARK-IT)

NCT07403799Parkinson Disease

Bial - Portela C S.A.

Observational

200

Bari, Brescia, Cagliari, Catanzaro, Chieti, Genova, Messina, Milan

2025-07-08

Recruiting

European Venous Registry

NCT06906250Deep Venous Disease of the Lower Limbs

IRCCS San Raffaele

Observational

100

Milan

2025-07-05

Recruiting

A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)

NCT06863272Castration-Resistant Prostatic Cancer, Metastasis

DrugsOpevesostat·Ifinatamab Deruxtecan·Abiraterone·Enzalutamide

Merck Sharp & Dohme LLC

Phase 1/2

360

Orbassano, Brescia, Milan, Naples, Roma

2025-07-03

Recruiting

Performance and Safety of Afluxin® in Patients With Gastroesophageal Reflux Disease

NCT06984484Gastroesophageal Reflux Disease (GERD)

Devintec Sagl

Not applicable

208

Genova, Milan, Naples, Padova, Roma, Rozzano (MI), Torino

2025-07-02

Recruiting

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

NCT07177352Alzheimers Disease

Hoffmann-La Roche

Phase 3

80,000

Naples, Rome, Genoa, Brescia, Milan, Palermo, Perugia

2025-07-02

Recruiting

TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

NCT07052903Transthyretin Amyloidosis With Cardiomyopathy

DrugNucresiran

Alnylam Pharmaceuticals

Phase 3

1,750

Ancona, Bologna, Brescia, Florence, Forlì, Lecce, Milan, Naples

2025-07-02

Not yet open

Antimicrobial Therapeutic Drug Monitoring During Lung Transplant Perioperative Phase

NCT06583642Lung Transplant Infection, Pneumonia, Bacterial, Antibiotic Resistant Strain

Policlinico Hospital

Observational

Milan

2025-07-01

By invitation

Maternal Risk, Fetal-Neonatal Brain Connectivity, and Early Neurodevelopment: A Longitudinal Observational Study

NCT07059286Pregnancy, Neurodevelopment, Brain Connectivity, Neurodevelopment Outcome

IRCCS San Raffaele

Observational

160

Milan

2025-07

By invitation

Reading-FREE Markers for Early Detection of Developmental Dyslexia

NCT07072104Preterm Birth, Developmental Dyslexia

Università Vita-Salute San Raffaele

Not applicable

Milan

2025-07

Recruiting

Personalization of External Beam Radiation Therapy in Localised Tumours

NCT07047495Breast Adenocarcinoma, Prostate Cancer (Adenocarcinoma)

European Institute of Oncology

Observational

Milan

2025-07

Recruiting

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

NCT06966700Breast Neoplasms, Triple Negative Breast Neoplasms, HR Low-Positive/HER2-Negative Breast Neoplasms

DrugsEpirubicin·Adriamycin·Xeloda·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

2,400

Monza, Livorno, Ancona, Bergamo, Genova, Milan, Pisa, Reggio Emilia

2025-06-30

Recruiting

A Study of IPN10200 for the Treatment of Cervical Dystonia in Adults

NCT06937931Cervical Dystonia

DrugCorabotase

Ipsen

Phase 2

132

Bologna, Milan, Pavia, Reggio Emilia

2025-06-30

Recruiting

A Patient-Directed Mobile Tool to Streamline the QoL Assessment and Monitoring in Urothelial Carcinoma

NCT06982794Urothelial Carcinoma (UC)

IRCCS San Raffaele

Observational

Milan

2025-06-30

Recruiting

A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis

NCT07054515Niemann-Pick Type C Disease, GM1 Gangliosidosis, GM2 Gangliosidosis

DrugNizubaglustat

Azafaros B.V.

Phase 3

147

Milan

2025-06-30

Active, closed

A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of GM1 Gangliosidosis or GM2 Gangliosidosis

NCT07082543Gangliosidoses, GM2, Gangliosidosis, GM1

DrugNizubaglustat

Azafaros B.V.

Phase 3

Milan

2025-06-30

Recruiting

A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease (NPC)

NCT07082725Niemann-Pick Type C Disease

DrugNizubaglustat

Azafaros B.V.

Phase 3

Milan

2025-06-30

Recruiting

Safety and Efficacy of T-DXd vs. CDK4/6i-based ET as First-line Therapy of HR-positive and HER2-low/Ultralow Advanced Breast Cancer Patients Classified as Non-luminal Subtype

NCT06486883Advanced Breast Cancer, Advanced Breast Carcinoma, Hormone Receptor Positive Breast Carcinoma

DrugsCDK4/6i·Trastuzumab deruxtecan

MedSIR

Phase 2

200

Ancona, Aviano, Florence, Genova, Milan, Modena, Monza, Naples

2025-06-30

Active, closed

Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic Disease Activity

NCT06979531Primary Sjögren's Syndrome

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 2

180

Catania, Milan, Palermo, Perugia, Rome

2025-06-30

Recruiting

A Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon 44 Skipping to Evaluate the Safety and Efficacy of ENTR-601-44

NCT07037862Duchenne Muscular Dystrophy (DMD)

DrugENTR-601-44

Entrada Therapeutics, Inc.

Phase 1/2

Milan, Rome

2025-06-30

By invitation

A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Moderate to Severe Hidradenitis Suppurativa

NCT07007637Hidradenitis Suppurativa

DrugSonelokimab

MoonLake Immunotherapeutics AG

Phase 3

835

Catania, Chieti, Cona, Florence, Milan, Modena, Naples, Perugia

2025-06-27

Recruiting

A Study to Assess the Efficacy and Safety of Emicizumab in Participants With Type 3 Von Willebrand Disease

NCT06998524Von Willebrand Disease, Type 3

DrugEmicizumab

Hoffmann-La Roche

Phase 3

Rome, Milan, Florence

2025-06-27

Recruiting

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

NCT07082738Chronic Obstructive Pulmonary Disease (COPD)

AstraZeneca

Phase 2

987

Busto Arsizio, Cuneo, Ferrara, Milan, Monza, Naples, Pavia, Roma

2025-06-27

Recruiting

Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer

NCT06995677Low-grade NMIBC, FGFR Gene Amplification, FGFR Gene Alterations, FGFR3 Gene Alteration

DrugTYRA-300

Tyra Biosciences, Inc

Phase 2

Rome, Milan, Pisa, Pozzuoli

2025-06-27

Recruiting

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

NCT06937099Crohn's Disease, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

290

Bologna, Castellana Grotte, Milan, Padova, Pisa, Rho, Roma, Rozzano

2025-06-26

By invitation

Global Open-Label Extension Study of Del-desiran for the Treatment of DM1

NCT07008469Myotonic Dystrophy Type 1, DM1, Myotonic Dystrophy, Myotonia

Avidity Biosciences, Inc.

Phase 3

199

Milan

2025-06-26

Recruiting

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

NCT06937086Ulcerative Colitis, Obesity or Overweight

DrugsMirikizumab·Tirzepatide

Eli Lilly and Company

Phase 3

350

Bologna, Castellana Grotte, Milan, Padova, Pisa, Rho, Roma, Rozzano

2025-06-26

Recruiting

INNODIA Family & Friends Early-Stage T1D Detection Protocol

NCT07118098Type 1 Diabetes (T1D), Pre Diabetes

INNODIA iVZW

Observational

30,000

Milan

2025-06-25

Recruiting

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

NCT07037459Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction, Obesity

DrugMaridebart cafraglutide

Amgen

Phase 3

5,056

Bari, Bergamo, Brescia, Cortona AR, Foggia, Forlì, Milan, Naples

2025-06-25

Recruiting

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

NCT06846281Relapsing Multiple Sclerosis

DrugsRemibrutinib·Ocrelizumab

Novartis Pharmaceuticals

Phase 3

400

Bergamo, Foggia, Genova, Milan, Pavia, Roma

2025-06-23

Active, closed

Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)

NCT06959225Hidradenitis Suppurativa

DrugRuxolitinib

Incyte Corporation

Phase 3

580

Catania, Cona, Florence, Milan, Naples, Roma, Rozzano, Torino

2025-06-23

Recruiting

Real-WorlD ZolbetUximab in Patients With HER-2 Negative and CLaudin 18.2 PosItive MetastatiC AdEnocarcinoma

NCT07427992Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

European Institute of Oncology

Observational

Milan

2025-06-20

Recruiting

Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance

NCT06658730Vascular Disease, Dissection, Dissection Aortic Aneurysm, Dissection of Aorta

W.L.Gore & Associates

Observational

1,500

Caserta, Milan

2025-06-19

Recruiting

A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

NCT07018323Graves' Disease

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 2

210

Rozzano, Acquaviva delle Fonti, Bergamo, Cuneo, Livorno, Milan, Naples, Pavia

2025-06-19

Recruiting

Multitarget Strategy for Primary Podocytopathies

NCT06718894Nephrotic Syndrome

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Not applicable

150

Milan, Pavia

2025-06-19

Active, closed

A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children and Adolescents (6 to <18 Years Old) With Moderate Atopic Dermatitis

NCT06832618Atopic Dermatitis

DrugRuxolitinib

Incyte Corporation

Phase 3

159

Catania, Milan, Naples, Padova, Rome

2025-06-17

Active, closed

A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab

NCT06880744Ulcerative Colitis

DrugsRisankizumab·Vedolizumab

AbbVie

Phase 3

573

Monserrato, Rozzano, Milan, Naples, Rome, Bologna, Padova, Palermo

2025-06-17

Recruiting

A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)

NCT06789913PIK3CA-Related Overgrowth Spectrum (PROS), Lymphatic Malformations, Vascular Malformations, PIK3CA Mutation

DrugRLY-2608

Relay Therapeutics, Inc.

Phase 2

277

Milan, Roma, Torino

2025-06-13

Recruiting

A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)

NCT06951711Bipolar Disorder Type I With Mania or Mania With Mixed Features

DrugKarXT

Bristol-Myers Squibb

Phase 3

274

Milan, Pisa, Siena, Ancona, Genova

2025-06-13

Recruiting

Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies

NCT06669299Ventricular Tachycardia (VT)

DrugMexiletine

IRCCS Ospedale San Raffaele

Not applicable

Milan

2025-06-12

Recruiting

A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)

NCT06885034Gastrointestinal Neoplasms

DrugRisvutatug rezetecan

GlaxoSmithKline

Phase 1/2

451

Milan, Pisa, Roma

2025-06-11

Recruiting

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

NCT06943872Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsSonrotoclax·Venclexta·Obinutuzumab·Venetoclax

BeOne Medicines

Phase 3

630

Bari, Cagliari, Catania, Ferrara, Milan, Modena, Pagani

2025-06-11

Recruiting

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

NCT06340568Endometrial Cancer

DrugsDoxorubicin·Docetaxel·Paclitaxel

BioNTech SE

Phase 3

480

Bari, Bologna, Catania, Meldola, Milan, Naples, Roma, Torino

2025-06-10

Recruiting

A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

NCT07038200Facioscapulohumeral Muscular Dystrophy, FSHD, FSHD - Facioscapulohumeral Muscular Dystrophy, FSHD1

DrugDel-brax

Avidity Biosciences, Inc.

Phase 3

200

Milan, Pisa, Roma

2025-06-10

Active, closed

REVEAL: A Phase 3 Study of Obudanersen (ION582) in Angelman Syndrome

NCT06914609Angelman Syndrome

DrugObudanersen

Ionis Pharmaceuticals, Inc.

Phase 3

156

Milan, Pisa, Roma

2025-06-10

Active, closed

Study to Evaluate Tulisokibart for Hidradenitis Suppurativa (MK-7240-012)

NCT06956235Hidradenitis Suppurativa

DrugTulisokibart

Merck Sharp & Dohme LLC

Phase 2

149

Ancona, Milan, Roma

2025-06-09

Recruiting

The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis

NCT06872892Bronchiectasis

DrugVerducatib

Boehringer Ingelheim

Phase 3

1,755

Ancona, Bologna, Catania, Genova, Messina, Milan, Monza (MB), Naples

2025-06-09

Active, closed

A Study to Learn More About the Effects and Long-Term Safety of Omaveloxolone (BIIB141) in Children and Teens With Friedreich's Ataxia

NCT06953583Friedreich Ataxia

DrugsOmaveloxolone·Skyclarys

Biogen

Phase 3

255

Rome, Conegliano, Milan

2025-06-09

Active, closed

Metaverse Applications in Clinical Neurorehabiliation: Device Feasibility

NCT07456475Neurological Disorder, Multiple Sclerosis, Parkinson Disease, Stroke

Istituto per la Ricerca e l'Innovazione Biomedica

Not applicable

Milan

2025-06-06

Recruiting

Post-Marketing Clinical Follow-Up Trial to Evaluate the Performance and Safety of the Medical Device 047 TD Dermatitis Cream in Adults and Children With Atopic and Contact Dermatitis Symptoms Confirmed by Clinical Parameters

NCT07056569Dermatitis, Contact, Dermatitis, Dermatitis, Chronic, Dermatitis, Eczematous

Biokosmes Srl

Not applicable

Milan, Verona, Voghera

2025-06-05

Recruiting

A Study of Momelotinib in Participants With Low-risk Myelodysplastic Syndrome

NCT06847867Myelodysplastic Syndromes

DrugMomelotinib

GlaxoSmithKline

Phase 2

Udine, Catania, Florence, Milan, Orbassano to, Rozzano MI

2025-06-05

Recruiting

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

NCT06852222Leukemia, Myeloid, Acute

DrugsBleximenib·Azacitidine·Venetoclax

Janssen Research & Development, LLC

Phase 3

600

Bergamo, Bologna, Brescia, Meldola, Milan, Pavia, Perugia, Pesaro

2025-06-04

Recruiting

Real-World Study of Foslevodopa/Foscarbidopa to Assess Quality of Life Outcomes in Adult Participants With Advanced Parkinson Disease

NCT06965374Parkinson Disease

AbbVie

Observational

270

Troina, Pozzilli, Milan, Naples, Turin, Rome, Venice, Ancona

2025-06-04

Recruiting

A Prospective Multicenter Diagnostic Biomarker Study to Discriminate Borderline From Stage I Invasive Ovarian Cancer

NCT06709872Stage I Ovarian Cancer, Borderline Ovarian Tumors

KU Leuven

Observational

400

Milan, Rome

2025-06-03

Active, closed

INCIDENCE, PREVALENCE AND OVERALL RISK OF ESOPHAGEAL CANCER IN ACHALASIA: A PROPENSITY-MATCHED POPULATION-BASED STUDY FROM A LARGE MULTICENTER DATABASE

NCT07022886Achalasia Cardia, Esophageal Cancer (EsC)

IRCCS San Raffaele

Observational

47,000

Milan

2025-06-03

Not yet open

Revisiting the Concept of Nerve Sparing Radical Hysterectomy

NCT06999824Cervical Cancers

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Observational

Milan

2025-06-01

Recruiting

Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma

NCT06986486Perihilar Cholangiocarcinoma, Klatskin Tumor

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Observational

Milan

2025-06-01

Recruiting

Readmission and Dehydration Prevention in Patients With Elective Ileostomy

NCT06824623Ileostomy - Stoma, Colorectal Surgery, Dehydration

Multidisciplinary Italian Study group for STOmas (MISSTO)

Observational

300

Legnano, Milan, Monza, Palermo, Rovigo, Sesto San Giovanni, Bologna

2025-06-01

Active, closed

Prospective Randomized Trial On Episiorrhaphy

NCT07045285Suture Materials

ASST Fatebenefratelli Sacco

Not applicable

100

Milan

2025-06-01

Not yet open

Study of Inflammatory Cells in the Blood and Cerebral Thrombus of Patients Affected by Cerebral Ischemia

NCT07033988Stroke Acute

IRCCS San Raffaele

Observational

380

Milan

2025-06

Recruiting

Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma

NCT06302569Bellini Carcinoma, Collecting Duct Carcinoma, Renal Medullary Carcinoma

DrugsEnfortumab Vedotin·Pembrolizumab

Giuseppe Procopio

Phase 2

Milan

2025-05-30

Recruiting

Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET

NCT06784752Somatostatin Receptor Positive (SSTR+), Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET)

DrugOctreotide LAR

Novartis Pharmaceuticals

Phase 3

240

Cona, Genova, Milan, Rozzano, Pisa, Roma

2025-05-30

Recruiting

A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

NCT06961006Malignant Melanoma

DrugsIntismeran autogene·Keytruda·Pembrolizumab

Merck Sharp & Dohme LLC

Phase 2

160

Milan, Naples, Padova, Roma

2025-05-29

Recruiting

High-Tech Rehabilitation Pathway for Acute Adult Neuromuscular Diseases - Fit4MedRob-Acute MND Project

NCT06822231Critical Illness Myopathy, Guillain Barré Syndrome, Critical Illness Polyneuromyopathy (CIPNM)

Istituti Clinici Scientifici Maugeri SpA

Not applicable

124

Bari, Genova, Milan, Modena, Montescano, Pavia, Roma, Telese Terme

2025-05-28

Active, closed

A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS)

NCT06782373VEXAS, VEXAS Syndrome

DrugPacritinib

Swedish Orphan Biovitrum

Phase 2

156

Milan, Padova, Reggio Emilia, Roma

2025-05-28

Recruiting

Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)

NCT06780098Lung Neoplasm

DrugsR-DXd·Ifinatamab Deruxtecan·Taxotere·Docetaxel

Merck Sharp & Dohme LLC

Phase 2

144

Florence, Milan, Roma

2025-05-28

Recruiting

Platelet-Rich Plasma Injections From Cord Blood + Penile Traction vs. Penile Traction Alone in Patients With Peyronie's Disease. Open-label, Single-center Randomized Study

NCT07010900Peyronie Disease, Penile Curvature, PRP Injection, Cord Blood

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Not applicable

Milan

2025-05-28

Recruiting

Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis

NCT07039916Generalized Myasthenia Gravis

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 3

231

Bergamo, Milan, Naples, Rome

2025-05-27

Recruiting

Immunological Phenotype of Desmoid-fibromatosis-affected Patients.

NCT07496242Desmoid-Type Fibromatosis

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Observational

200

Candiolo, Florence, Milan, Padova, Palermo, Rome

2025-05-27

Recruiting

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

NCT06941272Malignant Neoplasm

DrugPatritumab deruxtecan

Merck Sharp & Dohme LLC

Phase 1/2

Milan, Roma, Torino

2025-05-26

Recruiting

Pembrolizumab and Radiotherapy for Oligometastatic Head and Neck Cancer

NCT05815927Oligometastatic Squamous Cell Carcinoma of the Head and Neck

DrugPembrolizumab

European Organisation for Research and Treatment of Cancer - EORTC

Phase 3

200

Bologna, Cuneo, Florence, Milan, Naples, Ravenna, Rome

2025-05-23

Recruiting

A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

NCT06901531Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

DrugsZolbetuximab·Adrucil·Capecitabine·Oxaliplatin

Astellas Pharma Global Development, Inc.

Phase 3

500

Bergamo, Bologna, Brescia, Candiolo, Cremona, Florence, Meldola, Milan

2025-05-22

Recruiting

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

NCT06952504Endometrial Cancer

DrugsSacituzumab tirumotecan·Docetaxel·Keytruda·Paclitaxel

Merck Sharp & Dohme LLC

Phase 3

1,123

Meldola, Milan, Catania, Florence, Naples, Pisa, Roma, Torino

2025-05-22

Active, closed

A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia

NCT06843590Idiopathic Hypersomnia

DrugALKS 2680

Alkermes, Inc.

Phase 2

126

Bologna, Milan, Verona

2025-05-22

Recruiting

Impact of Exclusion Diet in Addition to Anti-TNF Therapy in Crohn's Disease and Ulcerative Colitis: a Prospective, Randomized, Double-arm, Open-label Study

NCT06896305Ulcerative Colitis (UC), Crohn Disease (CD)

IRCCS Ospedale San Raffaele

Not applicable

Milan

2025-05-22

Active, closed

Study of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants From Approximately 2 Months of Age

NCT06975878Pneumococcal Immunization, Healthy Volunteers

DrugsVaxneuvance·PCV21 vaccine·Vaxelis vaccine·Varivax

Sanofi

Phase 3

1,092

Rome, Bari, Foggia, Lecce, Milan, Parma

2025-05-22

Recruiting

Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.

NCT06697301Advanced Melanoma

DrugsEIK1001·Keytruda·Pembrolizumab

Eikon Therapeutics

Phase 2/3

740

San Giovanni Rotondo, Alessandria, Messina, Milan, Modena, Padova, Trento, Genoa

2025-05-22

Recruiting

Non-invasive Vibratory Stimulation of the Knee Muscles for the Improvement of the Somatosensory Input and Motor Performance

NCT07424066Vibration

University of Milano Bicocca

Not applicable

Milan

2025-05-20

Recruiting

Telerehabilitation With Digital Technologies for the Continuum of Care of Stroke Patients

NCT06978413Stroke

Fondazione Don Carlo Gnocchi ETS

Not applicable

160

Acerenza, Bari, Genova, Messina, Milan, Montescano, Pavia, Rome

2025-05-20

Recruiting

A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

NCT06876662Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma

DrugPirtobrutinib

Eli Lilly and Company

Phase 4

279

Bologna, Milan

2025-05-20

Recruiting

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

NCT06876649Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma

DrugPirtobrutinib

Eli Lilly and Company

Phase 4

787

Bologna, Milan

2025-05-20

Recruiting

Incidence of Late Haemorrhage After Invasive Gastroenterological Endoscopic Manoeuvre in Patients Treated With Anticoagulants Compared to Non-anticoagulated Patients

NCT07019077Bleeding

Centro Cardiologico Monzino

Observational

4,719

Milan

2025-05-19

Recruiting

Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation

NCT06830798Delayed Graft Function, DGF, Kidney Transplant

DrugRavulizumab

Alexion Pharmaceuticals, Inc.

Phase 3

450

Bologna, Milan, Padova, Parma, Torino

2025-05-19

Active, closed

Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC)

NCT06898957Small Cell Lung Cancer

DrugsTam-Peli·Tarlatamab·Durvalumab

Amgen

Phase 1

Candiolo to, Meldola (FC), Milan

2025-05-16

Recruiting

BIOlogical Waste Sample Collection for Progress in Oral and MAXillofacial Research

NCT07024251Oral and Maxillofacial Conditions

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Observational

383

Milan

2025-05-16

Recruiting

Small Airways Disease Functional Assessment in Idiopathic Pulmonary Fibrosis (SWIFT-IPF)

NCT07312305Idiopathic Pulmonary Fibrosis, Small Airways Disease

University of Milan

Observational

100

Milan

2025-05-15

Recruiting

Surgical vs Transcatheter Aortic Valve Replacement in YOUNG Patients

NCT06861361Symptomatic Severe Aortic Stenosis

Ceric Sàrl

Not applicable

1,180

Mercogliano, Milan, Parma, Roma, San Donato Milanese

2025-05-15

Recruiting

Digital Solutions for bEtter cAre

NCT07416513Cancer Diagnosis

European Institute of Oncology

Not applicable

200

Milan

2025-05-14

Recruiting

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

NCT06925737Prostate Cancer, Prostatic Neoplasms

DrugsIfinatamab Deruxtecan·Prednisolone·Prednisone·Docetaxel

Merck Sharp & Dohme LLC

Phase 3

1,440

Milan, Rozzano, Rome, Siena, Arezzo, Bergamo, Foggia, Terni

2025-05-13

Recruiting

A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

NCT06780085Carcinoma, Non-Small-Cell Lung

DrugsR-DXd·Ifinatamab Deruxtecan

Merck Sharp & Dohme LLC

Phase 2

Milan, Florence, Roma

2025-05-13

Recruiting

Validation of α-synuclein Modifications in Parkinson's dIsoRder Evolution

NCT06941012Parkinson Disease (PD)

Casa di Cura IGEA

Observational

1,200

Milan

2025-05-12

Active, closed

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)

NCT06925750Pulmonary Arterial Hypertension

DrugSotatercept

Merck Sharp & Dohme LLC

Phase 2

130

Milan, Verona, Bologna, Genova, Pavia, Roma, Sassari

2025-05-12

Recruiting

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

NCT06819891Moderately to Severely Active Crohns Disease

DrugAfimkibart

Hoffmann-La Roche

Phase 3

425

Matera, Bologna, Rome, Brescia, Milan, San Donato Milanese (MI), Negrar

2025-05-12

Recruiting

Efficacy of Corrective Rubber Insoles in Healthcare Professionals With Foot Overpronation

NCT07000838Hyperpronation, Overpronation, Pes Planus

University of Milan

Not applicable

Milan

2025-05-09

Recruiting

The Use of Two Bone Substitutes in Adjunct to EMD for the Treatment of One- and Two-wall Intrabony Defects.

NCT07546279Periodontitis, Bone Defects

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Not applicable

Milan

2025-05-08

Recruiting

Spontaneous Eye Blinking in Disorders of Consciousness

NCT06323031Disorders of Consciousness

Fondazione Don Carlo Gnocchi ETS

Observational

Sant'Angelo dei Lombardi, Ferrara, Florence, Milan

2025-05-08

Recruiting

Biological Markers and Advanced Imaging for Prostate Cancer Progression in Active Surveillance

NCT06866041Low-Risk Prostate Cancer

Università Vita-Salute San Raffaele

Not applicable

Milan

2025-05-07

By invitation

Specimen and Data Collection for a Novel Biomarker Combination for the Differential Diagnosis of Inflammatory Bowel Disease and Irritable Bowel Syndrome.

NCT07471490IBD (Inflammatory Bowel Disease), IBS (Irritable Bowel Syndrome), Gastrointestinal Symptoms

DiaSorin Inc.

Observational

300

Milan

2025-05-07

Recruiting

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

NCT06921785Hepatocellular Carcinoma

DrugsRilvegostomig·Tremelimumab·Atezolizumab·Bevacizumab

AstraZeneca

Phase 3

1,220

Bologna, Milan, Palermo, Perugia, Pisa, Roma, Rozzano

2025-05-06

Recruiting

Unmet Needs Among Patients With Isolated REM Sleep Behavior Disorder (iRBD) and Their Significant Others

NCT07498452REM Sleep Behavior Disorder, Isolated REM Sleep Behavior Disorder

Universita di Verona

Observational

150

Bologna, Genoa, Milan, Pavia, Cagliari, Troina, Pisa, Verona

2025-05-06

Recruiting

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

NCT06499285Myelodysplastic Syndromes

DrugElritercept

Takeda

Phase 3

225

Ancona, Turin, Florence, Milan, Pavia, Reggio Calabria, Rome, Rozzano

2025-05-06

Recruiting

A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

NCT06747351Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

DrugsTAK-881·Phesgo

Takeda

Phase 3

Milan, Rozzano, Orbassano, Brescia, Genova, Messina, Pavia, Pisa

2025-05-06

Recruiting

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

NCT06881784NSCLC (Non-small Cell Lung Cancer), Non-Small Cell Lung Cancer, NSCLC, NSCLC (Non-small Cell Lung Carcinoma)

DrugsCetuximab·Docetaxel

Revolution Medicines, Inc.

Phase 3

590

Milan, Rossano, Monza, Naples, Pisa, Roma, Rome

2025-05-06

Recruiting

Genetic Aortic Diseases and Cardiovascular Complications. An Observational Survey of Risk Factors.

NCT07391293Thoracic Aortic Aneurysm (TAA)

IRCCS Policlinico S. Donato

Observational

208

Milan

2025-05-06

Recruiting

Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML

NCT06652438Acute Myeloid Leukemia, Adult

DrugRevumenib

Stichting Hemato-Oncologie voor Volwassenen Nederland

Phase 3

448

Ancona, Bologna, Civitanova Marche, Milan, Pagani, Palermo, Perugia, Pescara

2025-05-05

By invitation

A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the Knee

NCT06916728Knee Injuries, Joint Surface Knee Lesions

Smith & Nephew, Inc.

Observational

170

Bergamo, Milan

2025-05-05

Recruiting

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

NCT06892548Advanced Lung Cancer

DrugsBNT324·Pumitamig

BioNTech SE

Phase 1/2

594

Candiolo, Milan, Naples, Roma, Verona

2025-05-02

Not yet open

Evaluation of Limb Function and Perception in Rehabilitation After Traumatic Wrist Fracture Surgery

NCT06866340Distal Radius Fractures, Rehabilitation, Body Perception

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Observational

100

Milan

2025-05-01

Recruiting

The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) Registry: An Observational Study on Cardiac Rehabilitation in Patients With Coronary Disease or Heart Failure

NCT07094737Cardiac Rehab, Heart Failure, Coronary Disease, Heart Conditions

Fondazione Don Carlo Gnocchi ETS

Observational

1,600

Milan

2025-05-01

Active, closed

Physical Activity-based Intervention in Depressed Patients: Clinical, Neurophysiological, Epigenetic and Metabolic Correlates

NCT06989944Major Depressive Disorder (MDD)

IRCCS Centro San Giovanni di Dio Fatebenefratelli

Not applicable

110

Brescia, Isernia, Milan, Pescara

2025-05-01

Active, closed

Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

NCT06813911Atherosclerotic Cardiovascular Disease (ASCVD)

DrugsPelacarsen·Inclisiran

Novartis Pharmaceuticals

Phase 3

246

Ancona, Caserta, Grosseto, Milan, Rozzano, Perugia, Pordenone, Salerno

2025-04-30

Active, closed

An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment

NCT06883240Von Willebrand Disease, Type 3

DrugsActivated Prothrombin Complex·Recombinant Factor VIIa

Hoffmann-La Roche

Observational

Rome, Milan, Florence

2025-04-29

Recruiting

High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project

NCT06881979Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy, Charcot-Marie-Tooth Disease

Istituti Clinici Scientifici Maugeri SpA

Not applicable

Genova, Milan, Modena, Montescano, Pavia, Roma, Telese Terme

2025-04-28

Active, closed

A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight

NCT06914895Type 1 Diabetes, Obesity, Overweight

DrugTirzepatide

Eli Lilly and Company

Phase 3

905

Bologna, Catanzaro, Florence, Milan, Naples, Padova, Roma, Torino

2025-04-25

Recruiting

Lung Ultrasound for Guiding Antibiotic Use in Pediatric Pneumonia

NCT06921993Pneumonia Childhood, Pneumonia, Lung Ultrasound, Antibiotic Stewardship

Meyer Children's Hospital IRCCS

Not applicable

659

Florence, Bergamo, Bologna, Brescia, Genova, Milan, Naples, Novara

2025-04-24

Recruiting

Patient Voice in the Treatment of Low-grade Gliomas: Use of Patient-reported Outcomes, Vorasidenib and Radiotherapy Compared

NCT07547163Glioma, Glioma of Brain, Low Grade Glioma of Brain, Low Grade Gliomas

DrugVorasidenib

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Observational

Milan

2025-04-23

Recruiting

A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer

NCT06827236Locally Advanced Breast Cancer, Unresectable Breast Carcinoma, Metastatic Breast Cancer

DrugPumitamig

BioNTech SE

Phase 1/2

380

Bologna, Genova, Milan, Naples, Roma

2025-04-23

Recruiting

Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)

NCT06965023ST-elevation Myocardial Infarction (STEMI), Microplastics, Nanoplastics, Pollution Exposure

Azienda Ospedaliera "Sant'Andrea"

Observational

130

Roma, Caserta, Catania, Ferrara, Forlì, Milan, Naples, Turin

2025-04-22

Recruiting

EMBRACE Tremor BiFUS

NCT06974916Essential Tremor

InSightec

Not applicable

100

Milan

2025-04-22

Recruiting

An Extension Study of Subjects Who Received an Avalyn Inhaled Antifibrotic Agent (SAIL)

NCT06951217Progressive Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis (IPF)

Avalyn Pharma Inc.

Phase 2

340

Pavia, Milan

2025-04-17

Active, closed

Pooled Analysis of Single-arm Studies of Budesonide/Glycopyrronium/Formoterol (BGF) in Routine Care Setting

NCT06712563Pulmonary Disease, Chronic Obstructive

DrugBevacizumab

AstraZeneca

Observational

2,000

Milan

2025-04-17

Recruiting

LONgitudinal and Integrated Evaluation of Biomarkers in reLation to phenotYpe in ALS

NCT07312240Amyotrophic Lateral Sclerosis

Istituto Auxologico Italiano

Not applicable

140

Milan

2025-04-17

Recruiting

Role of Extracellular Vesicles as Biomarkers of Pulmonary Involvement in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex

NCT07304856Lymphangioleiomyomatosis (LAM), Extracellular Vesicles; Generation and Function

University of Milan

Observational

Milan

2025-04-16

Recruiting

Peritoneal Ultrafiltration in Cardio Renal Syndrome.

NCT03994874Congestive Heart Failure

Iperboreal Pharma Srl

Phase 1/2

Chieti, Milan, Naples

2025-04-16

Active, closed

Machine Learning and Pregnancy Success Prediction in Fertility Treatments

NCT06884930Infertility (IVF Patients)

IRCCS San Raffaele

Observational

5,000

Milan

2025-04-16

Recruiting

OligoCare TwiCs (Trials Within Cohorts) Trial Comparing Acute Toxicity in Single-fraction vs Multiple-fraction SBRT for Metastasis-directed Treatment (SPRINT)

NCT06462963Breast Cancer, Prostate Cancer, NSCLC, Colorectal Cancer

European Organisation for Research and Treatment of Cancer - EORTC

Not applicable

302

Florence, Milan, Negrar, Roma, Torino

2025-04-15

Recruiting

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

NCT06890884Lymphoma, Large B-Cell, Diffuse

DrugsRituximab Biosimilar·Zilovertamab vedotin·Riabni·Polatuzumab Vedotin

Merck Sharp & Dohme LLC

Phase 2

594

Meldola, Rozzano, Palermo, Alessandria, Milan, Naples, Reggio Emilia

2025-04-11

Recruiting

The 3D Stent Study

NCT06898021Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)

CoreAalst BV

Observational

200

Milan

2025-04-11

Recruiting

Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers

NCT06906341Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Neoplasms, Endometrial Cancer

DrugsNab-paclitaxel /m^2·Relacorilant·Bevacizumab

Corcept Therapeutics

Phase 2

270

Catania, Milan, Pavia, Rome, Torino, Treviso

2025-04-11

Active, closed

ASCEND CSP IDE Study

NCT06830746Heart Failure, Ventricular Arrythmia

Abbott Medical Devices

Not applicable

414

Taranto, Milan

2025-04-11

Recruiting

Long Term Clinical Outcome After Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue

NCT06960343Arthroscopic Rotator Cuff Repair, Augmentation, Microfragmented Adipose Tissue

University of Milan

Observational

Milan

2025-04-11

Recruiting

A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

NCT06868277Carcinoma, Non-Small Cell Lung

DrugsRilvegostomig·Keytruda·Pembrolizumab

AstraZeneca

Phase 3

830

Candiolo, Lecco, Lucca, Meldola, Milan, Naples, Peschiera del Garda, Pisa

2025-04-10

Recruiting

A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

NCT06846671CLL, Chronic Lymphocytic Leukemia

DrugsIdelalisib·Tacabrutideg·Bendamustine·Venetoclax

BeOne Medicines

Phase 3

250

Bari, Florence, Milan, Naples, Novara, Pavia, Perugia, Roma

2025-04-10

Recruiting

Genetic and Biohumoral Factors Involved in Menière's Disease and Their Correlation With Phenotypes

NCT07518069Vertigo, Meniere's Disease, Vestibular Migraine

IRCCS San Raffaele

Observational

250

Milan

2025-04-09

Recruiting

An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome

NCT05066217Lennox Gastaut Syndrome

DrugClemizole HCl

Epygenix

Phase 3

260

Genoa, Pozzilli, Catanzaro, Florence, Milan, Pavia

2025-04-09

Recruiting

A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)

NCT06824467Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer

DrugsSteroid mouthwash (dexamethasone·Mvasi·Acetaminophen·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 3

770

Aviano, Milan, Pisa, Bari, Brescia, Naples, Padova, Roma

2025-04-09

Active, closed

Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

NCT06822790Hypertriglyceridemia

DrugPlozasiran

Arrowhead Pharmaceuticals

Phase 3

710

Rozzano, Bologna, Brescia, Milan, Palermo, Roma

2025-04-09

Recruiting

A Combination of Rituximab and CC-99282 as Front-line Therapy for Older Frail Patients With Diffuse Large B-cells Non-Hodgkin Lymphoma Evaluated With a Simplified Geriatric Assessment (sGA): a Phase II Study of the Fondazione Italiana Linfomi (FIL)

NCT06835530Diffuse Large B Cell Non-Hodgkin Lymphoma

DrugsGolcadomide·Rituximab

Fondazione Italiana Linfomi - ETS

Phase 2

Alessandria, Pescara, Ancona, Avellino, Aviano, Brescia, Florence, Milan

2025-04-09

Active, closed

Prevention of Capsular Contracture in Postmastectomy Patients Undergoing Implant-based Reconstructions

NCT06785610Capsular Contracture Associated With Implant

European Institute of Oncology

Not applicable

100

Milan

2025-04-08

Recruiting

Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis

NCT06408259Multiple Sclerosis, Relapsing-Remitting

DrugsFingolimod·Ozanimod

Bristol-Myers Squibb

Phase 3

194

Naples, Milan, Rome

2025-04-08

Recruiting

CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)

NCT06708299Recurrent Pericarditis

Cardiol Therapeutics Inc.

Phase 3

110

Milan, Padua, Torino, Udine

2025-04-07

Recruiting

Association of TNFAIP3 With Immune-mediated TTP

NCT06928233Thrombotic Thrombocytopenic Purpura, Acquired

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Not applicable

400

Milan

2025-04-07

Recruiting

Effect of Patiromer in Children Under 12 Years of Age With High Blood Potassium Levels

NCT05766839Hyperkalemia

DrugPatiromer

Vifor Pharma, Inc.

Phase 2

Milan, Rome

2025-04-06

Recruiting

PRospective Observational Study of STereotactic Body rAdiation Therapy With Androgen Deprivation Therapy for Organ-confined High-risk Prostate Cancer: the PROSTAR Trial

NCT06949254High Risk Prostate Cancer

Istituto Clinico Humanitas

Observational

Bergamo, Milan, Rozzano

2025-04-04

Active, closed

A Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy (DMD)

NCT06450639Duchenne Muscular Dystrophy

DrugSatralizumab

Hoffmann-La Roche

Phase 2

Rome, Milan

2025-04-04

Recruiting

Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer

NCT06801834Extensive Stage Small Cell Lung Cancer (ES-SCLC)

DrugsAmrubicin·Lurbinectedin·Topotecan·Sacituzumab Govitecan

Gilead Sciences

Phase 3

695

Aviano, Candiolo, Lucca, Milan, Naples, Pesaro, Peschiera del Garda, Roma

2025-04-04

Recruiting

Implementation and Validation of Instrumented Stair Climb Test

NCT06999850Stair Climbing, Instrumentation, Test

IRCCS Eugenio Medea

Not applicable

Bosisio Parini, Milan, Tradate

2025-04-04

Recruiting

Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and in Patients With Other Advanced Solid Tumors

NCT06726148Advanced HR+/HER2- Breast Cancer, Advanced CCNE1-amplified Solid Tumors, Extensive-stage Small Cell Lung Cancer

DrugsRibociclib·Fulvestrant

Novartis Pharmaceuticals

Phase 1/2

280

Milan, Modena

2025-04-03

Recruiting

Personalized High-Definition tDCS Protocols for Chronic Pain Treatment

NCT07432841Chronic Pain

Istituti Clinici Scientifici Maugeri SpA

Not applicable

144

Milan, Palermo, Pavia

2025-04-03

Recruiting

Application of da Vinci SP for Endometrial Cancer Surgical Staging

NCT07027046Endometrial Cancer

National Cancer Institute, Naples

Observational

564

Naples, Milan, Roma

2025-04-03

Recruiting

FDG-PET/CT vs. CT for Monitoring Metastatic Breast Cancer

NCT06877949Metastatic Breast Cancer, Response Monitoring

Odense University Hospital

Not applicable

420

Bologna, Milan

2025-04-02

Active, closed

A Study to Assess the Efficacy and Safety of Afimkibart (RO7790121) in Participants With Moderate to Severe Atopic Dermatitis

NCT06863961Atopic Dermatitis

DrugAfimkibart

Hoffmann-La Roche

Phase 2

162

Roma, Milan, Catania, Ancona

2025-04-01

Recruiting

The Dragon PLC Trial (DRAGON-PLC)

NCT06914648Primary Liver Cancer, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma

Maastricht University

Not applicable

358

Milan

2025-04-01

Not yet open

Screening for Hepatitis Virus B Protein X (HBx) in Colitis-associated Cancer (CAC)

NCT06833021Colitis-associated Colorectal Cancer (CAC)

IRCCS San Raffaele

Observational

Milan

2025-04-01

Recruiting

ASSOCIATION BETWEEN TEMPOROMANDIBULAR DISORDERS AND SLEEP DISORDERS

NCT06975709Temporomandibular Disorders (TMD), Sleep

IRCCS San Raffaele

Observational

100

Milan

2025-04-01

By invitation

Long-term Safety and Efficacy Study of Riliprubart in Participants With CIDP

NCT06859099Polyneuropathy, Inflammatory Demyelinating, Chronic

DrugRiliprubart

Sanofi

Phase 3

300

Genoa, Milan, Rozzano, Rome, Pavia, Pisa

2025-04-01

Not yet open

The Microbial Impact on Intestinal Fibrosis and the Associated Immune Microenvironment in Crohn's Disease

NCT06720961Crohn Disease (CD)

IRCCS San Raffaele

Observational

Milan

2025-04

Not yet open

Muscle Aging Evaluation

NCT06845748Preventing Age-Related Muscle Loss: the Role of Exercise in Improving Strength, Function, and Well-being

University of Milan

Not applicable

200

Milan

2025-04

Recruiting

Socket Reconstruction Technique and Immediate Implant Placement With Two Different Bone Substitute Materials.

NCT06517030Dental Implant

Università Vita-Salute San Raffaele

Not applicable

Milan

2025-04

Not yet open

TRACE4BUS for BI-RADS Classification

NCT06920108Breast Cancer

DeepTrace Technologies S.r.l.

Observational

590

Milan

2025-04

Not yet open

Robotic Nipple Sparing Mastectomy with Immediate Reconstruction

NCT06860217Breast Cancer, DCIS, BRCA Mutation

European Institute of Oncology

Not applicable

Milan

2025-04

Recruiting

Statin Effect on Arrhythmogenic Cardiomyopathy Disease Progression (SEARCH)

NCT06922994Arrhythmogenic Cardiomyopathy

DrugAtorvastatin

Centro Cardiologico Monzino

Phase 2

102

Pavia, Ancona, Milan, Naples

2025-03-31

Not yet open

Impact of Severe Tricuspid Regurgitation Correction on Gut Microbiota and Gastrointestinal Function

NCT06902922Tricuspid Regurgitation (TR)

Francesco Maisano

Observational

150

Milan

2025-03-31

Recruiting

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

NCT06731907Non-small Cell Lung Cancer

DrugsPatritumab deruxtecan·Abraxane·Paraplatin·Taxol

Merck Sharp & Dohme LLC

Phase 2

Milan, Roma

2025-03-30

Recruiting

Acute and Subacute Iliofemoral and/or Caval Deep Vein Thrombosis: Evaluation of Mechanical Thrombectomy Systems

NCT06288906Thrombosis, Venous

IRCCS San Raffaele

Observational

Milan

2025-03-30

Active, closed

A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Ulcerative Colitis

NCT06867094Colitis Ulcerative

DrugBalinatunfib

Sanofi

Phase 2

204

Genoa, Milan, Rozzano, Naples, Padua, Rome, Turin, Alessandria

2025-03-28

Recruiting

Screening for Intrapartum Fetal Compromise Using Placental Biomarkers

NCT07258329Pregnant Women

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

428

Bologna, Milan

2025-03-28

Recruiting

Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment

NCT06750289Eosinophilic Asthma

AstraZeneca

Phase 3

400

Bari, Bergamo, Brescia, Cagliari, Catanzaro, Genoa, Milan, Modena

2025-03-28

Recruiting

Real-World Study to Assess Subcutaneous Epcoritamab in Adult Participants With Diffuse Large B-Cell and Follicular Lymphoma

NCT06830759Diffuse Large B-cell Lymphoma, Follicular Lymphoma

AbbVie

Observational

700

Milan, Naples, Turin, Rome, Bari, Palermo

2025-03-28

Recruiting

A Phase 2 Study of PTX 100 in Patients With Relapsed/Refractory CTCL

NCT06854653CTCL

Prescient Therapeutics, Ltd.

Phase 2

115

Bologna, Brescia, Milan

2025-03-28

Recruiting

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

NCT06890598Carcinoma, Non-Small-Cell Lung

DrugsOlomorasib·Durvalumab·Pembrolizumab

Eli Lilly and Company

Phase 3

700

Bari, Catania, Genova, Meldola, Milan, Monza, Naples, Orbassano

2025-03-27

Recruiting

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

NCT06989112Endometrial Cancer

DrugsRilvegostomig·Taxotere·Paraplatin·Trastuzumab deruxtecan

AstraZeneca

Phase 3

600

Catania, Florence, Milan, Monza, Naples, Reggio Emilia, Roma, Rome

2025-03-27

Recruiting

A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

NCT06644781Esophageal Squamous Cell Carcinoma

DrugsIfinatamab Deruxtecan·Irinotecan·Docetaxel·Paclitaxel

Daiichi Sankyo

Phase 3

510

Milan, Naples, Padova, Rome, Rozzano

2025-03-27

Recruiting

Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS

NCT06126315Amyotrophic Lateral Sclerosis

Mario Negri Institute for Pharmacological Research

Phase 2/3

246

Brescia, Bergamo, Milan, Naples, Novara, Padova, Palermo, Pergine Valsugana

2025-03-26

Recruiting

Dietary Intervention to Improve Fertility in Women With Endometriosis Undergoing IVF

NCT06885125Endometriosis

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Not applicable

438

Milan

2025-03-24

Recruiting

Role of Photon Counting CT in Detecting Liver Metastatis From Colorectal Cancer

NCT06753903Colorectal Cancer

IRCCS San Raffaele

Observational

100

Milan

2025-03-24

Recruiting

A Modified Baveno Classification of Obstructive Sleep Apnoea Based on Sleepiness and Cardiovascular Scores

NCT06861686Obstructive Sleep Apnea (OSA)

Wissenschaftliches Institut Bethanien e.V

Observational

1,800

Milan, Pavia

2025-03-24

Recruiting

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

NCT06914128MTAP-deleted Solid Tumors

Bayer

Phase 1/2

450

Aviano, Milan, Roma, Rozzano

2025-03-21

Active, closed

Study of Eftilagimod Alfa (Efti) in Combination With Pembrolizumab and Chemotherapy Versus Placebo in Combination With Pembrolizumab and Chemotherapy in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) (TACTI-004)

NCT06726265Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

DrugsEfti·Pemetrexed·Keytruda·Paclitaxel

Immutep S.A.S.

Phase 3

756

Avellino, Aviano, Candiolo, Milan, Naples, Perugia, Reggio Emilia, Terni

2025-03-21

Active, closed

Radiological Markers in Locally Advanced Rectal Cancer

NCT06843655Locally Advanced Rectal Carcinoma

IRCCS San Raffaele

Observational

179

Milan

2025-03-21

Recruiting

Infection Control Link Nurses Program to Improve Compliance With Standard Precautions, Hand Hygiene, and Prevent Healthcare-Associated Infections

NCT06857825Standard Precautions, Hand Hygiene Behavior, Healthcare Associated Infections

Centro Cardiologico Monzino

Not applicable

100

Milan

2025-03-20

Active, closed

Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)

NCT06788912Lung Neoplasm Malignant

DrugsSteroid mouthwash (dexamethasone·Acetaminophen·Ribociclib·Sacituzumab tirumotecan

Merck Sharp & Dohme LLC

Phase 2

Florence, Milan, Roma

2025-03-20

Active, closed

A Study of Navenibart in Participants With Hereditary Angioedema

NCT06842823Hereditary Angioedema (HAE)

DrugNavenibart

Astria Therapeutics, Inc.

Phase 3

157

Milan, Monserrato, Padova, San Donato Milanese, Torino

2025-03-20

Recruiting

Liver Transplantation for Unresectable Intrahepatic Colangiocarcinoma After Sustained Response to Neoadjuvant Treatments

NCT06862934Intrahepatic Cholangiocarcinoma (Icc)

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Observational

Milan

2025-03-20

Recruiting

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

NCT06819007Ovarian Cancer

DrugsTrastuzumab deruxtecan·Bevacizumab

Daiichi Sankyo

Phase 3

582

Bari, Bologna, Catania, Milan, Monza, Naples, Pisa, Ponderano

2025-03-19

Recruiting

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

NCT06883305Chronic Obstructive Pulmonary Disease (COPD)

DrugTezepelumab

AstraZeneca

Phase 3

990

Cona, Florence, Milan, Montebelluna, Naples, Pavia, Roma, Sassari

2025-03-18

Recruiting

Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

NCT07032662Chronic Inflammatory Demyelinating Polyneuropathy

Immunovant Sciences GmbH

Phase 2

162

Bergamo, Bologna, Brescia, Milan, Pavia, Pisa, Roma, Siena

2025-03-18

Active, closed

Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

NCT06858878Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight

DrugMaridebart cafraglutide

Amgen

Phase 3

1,105

Bologna, Chieti, Florence, Milan, Palermo

2025-03-17

Recruiting

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

NCT06819878Moderately to Severely Active Crohns Disease

DrugAfimkibart

Hoffmann-La Roche

Phase 3

600

Bari, Catanzaro, Naples, Rome, Milan, Monza MI, Pavia, Rho

2025-03-17

Recruiting

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

NCT06841354Triple Negative Breast Neoplasms

DrugsAbraxane·Sacituzumab tirumotecan·Paraplatin·Taxol

Merck Sharp & Dohme LLC

Phase 3

1,000

Rome, Bologna, Genova, Milan, Novara, Padova, Roma

2025-03-16

Recruiting

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

NCT06677060Heart Failure

DrugBaxdrostat/dapagliflozin

AstraZeneca

Phase 3

11,300

Alessandria, Bari, Bergamo, Brescia, Chiavari, Cona, Foggia, Milan

2025-03-14

Active, closed

A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration

NCT06795048Neovascular Age-related Macular Degeneration (nAMD)

DrugsVabysmo·Faricimab

Hoffmann-La Roche

Phase 4

274

Foggia, Rome, Milan, Napoli, Torrette - Ancona

2025-03-14

Active, closed

A Study to Assess a New Medicine Called IPN01195 When Administered Alone in Adults With Advanced Solid Tumours

NCT06833008Advanced Solid Tumor

Ipsen

Phase 1/2

Milan, Naples

2025-03-14

Recruiting

Pilot Study on Collaborative, Comprehensive, Multidimensional and Quality of Life Tools for Priority Definition, Shared Decision Making, Outcome Evaluation and Quality of Care Improvement in ASD Individuals and Programs in the Real World.

NCT07393152Autism Spectrum Disorders

Antonella Costantino

Observational

400

Bosisio Parini, Busto Arsizio, Milan

2025-03-13

Active, closed

A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer

NCT06764485Metastatic Castration-resistant Prostate Cancer

DrugsAbiraterone·Enzalutamide·Docetaxel

Celgene

Phase 3

960

Milan, Orbassano, Rome, Padova, Arezzo, Foggia, Naples, Terni

2025-03-13

Recruiting

A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

NCT06615479Relapsed or Refractory Multiple Myeloma (RRMM)

DrugsArlo-cel·Carfilzomib·Pomalidomide·Daratumumab

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Phase 3

440

Milan, Rozzano, Turin, Bologna, Genova, Udine

2025-03-12

Recruiting

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

NCT06792695Metastatic Colorectal Cancer

DrugsFOLFIRI (Fluorouracil (5-FU), leucovorin, irinotecan)·Volrustomig·Bevacizumab

AstraZeneca

Phase 2

Bologna, Castelfranco Veneto, Florence, Milan, Naples, Pavia, Pisa, Roma

2025-03-12

Active, closed

Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

NCT06858839Obesity

DrugMaridebart cafraglutide

Amgen

Phase 3

3,853

Bologna, Chieti, Florence, Milan, Palermo, Pisa, Roma

2025-03-12

Recruiting

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

NCT06641466Menstrual Migraine

DrugRimegepant

Pfizer

Phase 3

723

Avezzano, Rome, Bologna, Florence, Milan, Pavia, Roma

2025-03-11

Recruiting

Impact Assessment of SALSA (Sensing and Automation for Freedom, Security, Autonomy) Technological Solutions

NCT07066202Generalized Mental, Social and/or Motor Disability

Fondazione Don Carlo Gnocchi ETS

Observational

Milan

2025-03-11

Recruiting

A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

NCT06833073Urinary Bladder Neoplasms, Non-Muscle Invasive Bladder Neoplasms, Carcinoma in Situ

DrugIntismeran autogene

Merck Sharp & Dohme LLC

Phase 2

308

Milan, Rome, Arezzo, Roma

2025-03-11

Recruiting

Parvovirus B19 Infection in Pregnancy: Clinical Manifestations and Fetus/Newborn Outcome

NCT07338279Parvovirus B19 Infection, Pregnancy

Fondazione IRCCS Policlinico San Matteo di Pavia

Observational

150

Pavia, Brescia, Milan, Monza

2025-03-06

Recruiting

Study to Evaluate Adverse Events and Efficacy of Intravenous (IV) Telisotuzumab Adizutecan in Combination With a PD-1 Immune Checkpoint Inhibitor in Adult Participants With Advanced or Metastatic Non-Squamous NSCLC With No Prior Treatment for Advanced Disease, and No Actionable Genomic Alterations

NCT06772623Non Small Cell Lung Carcinoma, c-MET

DrugsBudigalimab·Telisotuzumab Adizutecan·Pemetrexed·Cisplatin

AbbVie

Phase 1/2

252

Meldola, Milan, Rome, Orbassano, Ancona, Bologna

2025-03-06

Recruiting

Study to Provide Continued Access to Treatment for Patients Completing a Previous Trial With Efanesoctocog Alfa

NCT06716814Haemophilia A (Moderate or Severe)

DrugEfanesoctocog alfa

Swedish Orphan Biovitrum

Phase 3

104

Catanzaro, Florence, Milan, Naples, Parma, Rome, Rozzano, Vicenza

2025-03-06

Recruiting

Atezolizumab and Chemotherapy Treatment as T-cell Activators in Metastatic Triple Negative Breast Cancer Patients

NCT06690840Triple Negative Breast Cancer

DrugAtezolizumab

European Institute of Oncology

Phase 2

Monza, Roma, Brindisi, Milan

2025-03-06

Recruiting

Evaluate Optimization of CRS Profile for Glofit Monotherapy and Glofit+GemOx in R/R Aggressive B-NHL

NCT06806033Relapsed or Refractory Aggressive B-Cell Non-Hodgkins Lymphoma

DrugsGlofitamab·Obinutuzumab·Oxaliplatin·Gemcitabine

Hoffmann-La Roche

Phase 2

130

Naples, Meldola, Brescia, Milan, Rozzano

2025-03-05

Recruiting

A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)

NCT06796907Tumours, Gynecological

DrugsMo-Rez·Dostarlimab·Bevacizumab

GlaxoSmithKline

Phase 1/2

305

Milan, Roma, Naples

2025-03-04

Recruiting

Studying Nerve Function and Structure in Charcot-Marie-Tooth Disease, Anti-MAG Neuropathy and CIDP

NCT07461896Charcot-Marie-Tooth, CMT1A, Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Polyneuropathy Associated With Anti-MAG Antibodies (Anti-MAG Polyneuropathy)

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Observational

Milan

2025-03-03

Recruiting

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

NCT06671483Psoriatic Arthritis

DrugZasocitinib

Takeda

Phase 3

1,088

Torrette, Rome, Milan, Rozzano, Padova, Florence, Pisa

2025-03-03

Active, closed

Study of Zelenectide Pevedotin in Participants With Advanced Breast Cancer

NCT06840483Breast Cancer

DrugZelenectide pevedotin

BicycleTx Limited

Phase 2

Meldola, Ancona, Milan

2025-03-03

Recruiting

A Prospective Observational Study of Artificial Intelligence Morphometric Evaluation of Vertebral Fractures

NCT06449742Vertebral Fracture, Osteoporosis

IRCCS San Raffaele

Observational

250

Milan

2025-03-01

Recruiting

A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

NCT06764875HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma

DrugsRilvegostomig·Trastuzumab deruxtecan·Trastuzumab·Adrucil

AstraZeneca

Phase 3

840

Cagliari, Florence, Milan, Naples, Padova, Rozzano, Torino, Tricase

2025-03-01

Recruiting

A Multi-omics Approach to Disclose Progression and Underlying Biology of Head and Neck Adenoid Cystic Carcinoma

NCT07507578Adenoid Cystic Carcinoma of the Salivary Gland, Adenoid Cystic Carcinoma of the Head and Neck

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Observational

114

Milan

2025-03-01

Active, closed

Role of Cardiovascular Imaging in the Early Diagnosis of Hypertrophic Cardiomyopathy in Women

NCT06882668Hypertrophic Cardiomyopathy (HCM)

IRCCS San Raffaele

Observational

Milan

2025-03-01

Active, closed

Adaptive and Trained Immunity in the Pathogenesis of IgG4-Related Disease

NCT06844864IgG4 Related Disease

IRCCS San Raffaele

Observational

Milan

2025-03-01

Recruiting

Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib

NCT06855498Hidradenitis Suppurativa (HS)

DrugPovorcitinib

Incyte Corporation

Phase 3

600

Bari, Brescia, Catania, Chieti, Florence, L’Aquila, Milan, Naples

2025-02-28

Recruiting

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis

NCT06517875Primary Myelofibrosis, Myelofibrosis; Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis

DrugsMomelotinib·Reblozyl·Luspatercept

GlaxoSmithKline

Phase 2

Bologna, Catania, Florence, Meldola FC, Milan, Roma

2025-02-28

Active, closed

Efficacy of Cosmetic Product RV3278B-OS0386 in the Maintenance Phase After Oral Isotretinoin Treatment of Adults Subjects With Facial Acne.

NCT07341659Acne

Pierre Fabre Dermo Cosmetique

Not applicable

102

Milan, Roma

2025-02-28

Recruiting

Spatially and Temporally Resolving Predictive Biomarkers of Postoperative Recurrence and Complications in Chronic Intestinal Inflammation

NCT06516341Ulcerative Colitis, Crohn Disease

IRCCS Ospedale San Raffaele

Observational

Milan

2025-02-27

Recruiting

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

NCT06767514Non-Small Cell Lung Cancer

DrugsIvonescimab·Pembrolizumab

Summit Therapeutics

Phase 3

780

Rome, Bari, Bergamo, Milan, Orbassano, Parma, Peschiera del Garda

2025-02-27

Recruiting

A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

NCT06722235Immune Thrombocytopenic Purpura (ITP)

DrugMezagitamab

Takeda

Phase 3

171

Naples, Rome, Catania, Bologna, Milan, Monza, Novara, Torino

2025-02-27

Active, closed

Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches

NCT06856850ALS (Amyotrophic Lateral Sclerosis), FTD, Neuropathic, Psychiatric Disorders

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Observational

230

Milan, Naples, Sassari, Sesto Fiorentino

2025-02-27

Recruiting

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

NCT06731478Gastric Cancer, Gastroesophageal Junction Cancer

DrugsTrastuzumab deruxtecan·Trastuzumab·Keytruda·Pembrolizumab

Daiichi Sankyo

Phase 3

726

Catania, Florenze, Genova, Milan, Modena, Naples, Padova, Pisa

2025-02-27

Recruiting

National Multicentre Study on Lipid Profile in Noonan Syndrome and Related Disorders: Trends by Age, Gender and Genotype

NCT07464821RASopathies, Noonan Syndrome

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

200

Alessandria, Bari, Bologna, Florence, Genova, Messina, Milan, Modena

2025-02-26

Recruiting

Improved Recovery of Walking in Acquired Muscle Weakness

NCT06786390Critical Illness Myopathy, Critical Illness Polyneuropathy

Fondazione Don Carlo Gnocchi ETS

Not applicable

Milan

2025-02-25

Recruiting

GEAM Study Aims At Assessing the Role of Genetic Testing in Patients with Arrhythmic Myocarditis.

NCT06889662Myocarditis, Ventricular Arrythmia

Scientific Institute San Raffaele

Observational

262

Milan

2025-02-25

Recruiting

A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)

NCT06747949Sjögren's Syndrome

DrugDazodalibep

Amgen

Phase 3

844

Udine, Rome, Milan, Turin, Verona, Pisa, Reggio Emilia

2025-02-25

Recruiting

A Study to Compare the Efficacy and Safety of BMS-986489 (Atigotatug+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

NCT06646276Extensive-Stage Small Cell Lung Cancer

DrugsEtoposide·Atezolizumab·Nivolumab·Carboplatin

Bristol-Myers Squibb

Phase 3

530

Naples, Milan, Rome, Perugia, Peschiera del Garda, Bologna

2025-02-25

Active, closed

Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALY

NCT05485831Lennox Gastaut Syndrome, Dravet Syndrome, Tuberous Sclerosis Complex

DrugCannabidiol

Jazz Pharmaceuticals

Observational

111

Bologna, Catanzaro, Chieti, Florence, Genova, Messina, Milan, Naples

2025-02-24

Active, closed

An Open-label Study to Assess the Safety, Efficacy, and Cellular Kinetics of YTB323 in Relapsing Multiple Sclerosis

NCT06617793Relapsing Multiple Sclerosis

DrugRapcabtagene autoleucel

Novartis Pharmaceuticals

Phase 1/2

Genova, Milan

2025-02-24

Recruiting

Gender Impact On Physical Activity In Chronic Musculoskeletal Disorders Prevention

NCT06747052Physical Activity, Musculoskeletal Disease, Gender Equity

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Observational

1,310

Milan

2025-02-24

Recruiting

Decoding the Inflammasome Influence on Treatment Response in Acute Myeloid Leukemia

NCT06535113Acute Myeloid Leukemia

Ciceri Fabio

Observational

Reggio Calabria, Milan

2025-02-22

Recruiting

Cetuximab Plus Platinum and Taxane-based Chemotherapy, Followed by Avelumab and Cetuximab, as First-line Treatment for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) Patients With a PD-L1 Combined Positive Score (CPS)≥1≤19.

NCT06869473Head and Neck Squamous Cell Carcinoma (HNSCC), Recurrent Head and Neck Cancer, Metastatic Head and Neck Cancer

Gruppo Oncologico del Nord-Ovest

Phase 2

Cagliari, Catania, Florence, Milan, Rozzano, Naples, Roma

2025-02-20

Active, closed

The Use of Artificial Intelligence for the Prediction of Recurrence After Resection of Colorectal Liver Metastases

NCT07385521Colorectal Liver Metastasis (CRLM), Liver Resection, Hepatectomy, Liver Ablation

Francesco De Cobelli

Observational

1,000

Milan

2025-02-19

Recruiting

HappyMums Mobile Application Study

NCT06578845Pregnancy, Antenatal Depression

King's College London

Observational

1,000

Milan

2025-02-18

Recruiting

Matching Primary Tumor and Blood Gene Expression Analysis of HPV-negative Squamous Head and Neck Cancers

NCT07512921Head and Neck (HNSCC)

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Observational

300

Milan, Sassari

2025-02-18

Recruiting

A Study of Neoadjuvant Dostarlimab Plus Capecitabine Plus Oxaliplatin (CAPEOX) Vs CAPEOX With Previously Untreated T4N0 or Stage III Mismatch Repair Proficient (MMRp)/Microsatellite Stable (MSS) Colon Cancer

NCT06567782Neoplasms, Colon

DrugsCapeox·Dostarlimab

GlaxoSmithKline

Phase 2

120

Milan, Roma, Udine

2025-02-18

Recruiting

Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold System in the Treatment of Subjects With Long de Novo Lesions

NCT07091682Coronary Artery Disease, Atherosclerosis of Coronary Artery, Myocardial Ischemia, Ischemic Heart Disease

Biotronik AG

Not applicable

100

Milan, Verona

2025-02-18

Active, closed

Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01

NCT06727565Head and Neck Squamous Cell Carcinoma

DrugsDomvanalimab·Zimberelimab·Paclitaxel·Carboplatin

Gilead Sciences

Phase 2

Milan, Naples

2025-02-18

Recruiting

A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

NCT06697197Advanced Solid Tumors

DrugsNivolumab and rHuPH20·Opdualag·Bevacizumab

Bristol-Myers Squibb

Phase 1/2

413

Milan, Rozzano

2025-02-17

Recruiting

MPNdpoint. Single-center, Retrospective, Prospective Study of the Outcome of Patients With Philadelphia-negative Chronic Myeloproliferative Neoplasms

NCT07863466Myelofibrosis (MF), Polycythemia Vera, Essential Thrombocythaemia

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Observational

1,190

Milan

2025-02-17

By invitation

An Innovative Method in SAliva Samples for the Early Differential Diagnosis of High-impact NeuroDegenerative Diseases Through Raman Spectroscopy

NCT06875739Neurodegenerative Disorders, Parkinson Disease, Alzheimer Disease, Parkinsonian Disorders

Fondazione Don Carlo Gnocchi ETS

Observational

310

Cagliari, Florence, Milan

2025-02-14

Recruiting

Multidisciplinary Dissection of Renal and Metabolic Effects of Glyfozines on Elderly Patients: From Molecular Aspects to Clinical Indications

NCT07119424Elderly Patients (>65 Years), Diabetes (DM), Heart Disease, Renal Diseases

Chiara Lanzani

Observational

300

Milan

2025-02-14

Recruiting

Study on Plasmablastic Lymphoma Patients

NCT06781359Plasmablastic Lymphoma

Fondazione Italiana Linfomi - ETS

Observational

200

Aviano, Ascoli Piceno, Brescia, Cuneo, Florence, Milan, Monza, Novara

2025-02-14

Recruiting

A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

NCT06810505Chronic Migraine

DrugAtogepant

AbbVie

Phase 3

420

Milan, Rome

2025-02-13

Recruiting

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

NCT06760819Advanced Solid Tumors, HER2 Mutation

DrugSevabertinib

Bayer

Phase 2

111

Milan, Reggio Emilia, Roma

2025-02-13

By invitation

A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)

NCT06908226Developmental and Epileptic Encephalopathy

DrugBexicaserin

Longboard Pharmaceuticals

Phase 3

324

Florence, Genoa, Milan, Pavia, Rome, Verona

2025-02-12

Active, closed

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

NCT06834347Chronic Rhinosinusitis With Nasal Polyps

DrugsItepekimab·Mometasone furoate

Sanofi

Phase 3

231

Cona, Florence, Genoa, Milan, Padua, Rome, Bologna

2025-02-12

Recruiting

A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)

NCT06858579Chronic Inflammatory Demyelinating Polyneuropathy

DrugClaseprubart

Dianthus Therapeutics

Phase 3

256

Bergamo, Bologna, Genova, Gussago, Milan, Modena, Monza, Pavia

2025-02-10

Active, closed

Study of Oral Atogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine

NCT06806293Menstrual Migraine (MM)

DrugAtogepant

AbbVie

Phase 3

468

Florence, Milan, Naples, Rome, Latina, Pavia, Perugia, Udine

2025-02-10

By invitation

A Pilot Study Of The ALPFA Benign Prostatic Hyperplasia (BPH) Pulsed Field Ablation (PFA) System

NCT06965582Benign Prostatic Hyperplasia

ALPFA Medical

Not applicable

100

Milan

2025-02-07

Active, closed

Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer

NCT06619236Platinum-resistant Ovarian Cancer

DrugsRina-S·Pegylated liposomal doxorubicin·Topotecan·Gemcitabine

Genmab

Phase 3

584

Brindisi, Milan, Ponderano, Roma, Torino

2025-02-07

Active, closed

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

NCT06834360Chronic Rhinosinusitis With Nasal Polyps

DrugsItepekimab·Mometasone furoate

Sanofi

Phase 3

216

Milan, Naples, Catania

2025-02-06

Recruiting

A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum

NCT06624670Pyoderma Gangrenosum

DrugsSpesolimab·Prednisolone·Prednisone

LEO Pharma

Phase 3

Milan, Pisa, Roma, Rozzano (MI), Torino

2025-02-05

Recruiting

LEOPARD Training and Validation Data Collection Study

NCT06675604Decompensated Liver Cirrhosis, Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Hepato-cellular Carcinoma

Assistance Publique - Hôpitaux de Paris

Observational

4,500

Ancona, Bari, Bologna, Genova, Milan, Modena, Naples, Padova

2025-02-04

Recruiting

Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

NCT06651970Chronic Lymphocytic Leukaemia, Moderate to Severe Cardiac Impairment

DrugAcalabrutinib

AstraZeneca

Phase 4

Cagliari, Florence, Milan, Pavia, Perugia

2025-02-04

Recruiting

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

NCT06618287Lung Cancer, Breast Cancer

DrugsPumitamig·Iza-bren·Osimertinib·Opdivo

Bristol-Myers Squibb

Phase 1/2

416

Aviano, Milan, Candiolo, Florence, Roma

2025-02-04

Recruiting

Efficacy and Safety of Zelpultide Alfa in Preterm Neonates at High Risk of Developing Bronchopulmonary Dysplasia (BPD)

NCT06897839Bronchopulmonary Dysplasia

Airway Therapeutics, Inc.

Phase 2/3

366

Bologna, Genova, Milan, Naples, Padova

2025-02-03

Recruiting

Brain Fog in Sleep Apnea

NCT06664450Obstructive Sleep Apnea

Fondazione Don Carlo Gnocchi ETS

Observational

Milan

2025-02-03

Recruiting

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

NCT06556563Glioblastoma

DrugsTemozolomide·Keytruda·Pembrolizumab

NovoCure GmbH

Phase 3

741

Torino, Bologna, Milan, Naples, Padova, Rozzano, Siena

2025-02-03

By invitation

Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE

NCT06679881Hereditary Angioedema (HAE)

DrugDeucrictibant

Pharvaris Netherlands B.V.

Phase 3

170

Milan, Padova, Palermo, Roma

2025-02-01

Not yet open

Point-of-care Low-field MRI in Acute Stroke

NCT05816213Stroke, Ischemic Stroke, Hemorrhagic Stroke, Magnetic Resonance Imaging

University of L'Aquila

Observational

300

Avezzano, Chieti, L’Aquila, Milan

2025-02-01

Recruiting

Anti PD-1 Plus Postbiotic Versus Anti PD-1 Alone in Locally Advanced or Metastatic, Treatment naïve, Cutaneous Melanoma Study

NCT07050940Melanoma Metastatic

Azienda Ospedaliera di Perugia

Not applicable

Bari, Torino, Milan, Perugia

2025-02-01

Recruiting

A Prospective Randomised Study of Treatment Selection Based on Epigenetic Markers Versus Standard of Care Treatment Selection in Adults With CROHN's Disease

NCT07363044Crohn Disease (CD)

Alimentiv Inc.

Not applicable

378

Castellana Grotte, Florence, Milan, Roma, Rome, San Giovanni Rotondo

2025-02-01

Not yet open

Optimization of Heart Failure (HF) Medical Therapy After Transcatheter Valve Intervention (TVI) in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF)

NCT06667128Heart Failure, Valvulopathy, Aortic Stenosis, Aortic Regurgitation Disease

IRCCS Ospedale San Raffaele

Not applicable

160

Milan

2025-02-01

Not yet open

Hemopatch Implication After Axillary Dissection for Breast Cancer

NCT06744998Breast Cancer

European Institute of Oncology

Not applicable

190

Milan

2025-02

Recruiting

An Ex-US Study to Assess Treatment Persistence With Risankizumab in Adult Participants With Psoriatic Arthritis

NCT06764693Psoriatic Arthritis

AbbVie

Observational

1,200

Rozzano, Milan, Naples, Rome, Ancona, Brescia, Campobasso, Catania

2025-01-31

Recruiting

Multimodal Prehabilitation in Cancer Surgery

NCT06788834Cancer Surgery

Università Vita-Salute San Raffaele

Not applicable

400

Catanzaro, Florence, Genova, Milan, Monza, Naples, Padova, Udine

2025-01-30

Recruiting

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

NCT06564038Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma, Mantle-cell Lymphoma, Large B-cell Lymphoma

DrugsSurovatamig·Acalabrutinib·Vincristine·Doxorubicin

AstraZeneca

Phase 1/2

408

Bologna, Milan

2025-01-30

Active, closed

Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)

NCT06710132Solid Tumors, Gastric Cancer, Non-Small Cell Lung Cancer (NSCLC), Pancreatic Cancer

DrugM9140

EMD Serono Research & Development Institute, Inc.

Phase 1/2

184

Rome, Ancona, Milan, Naples, Padova, Pisa, Reggio Emilia, Roma

2025-01-29

Recruiting

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

NCT06788990Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma

DrugsFicerafusp alfa·Keytruda·Pembrolizumab

Bicara Therapeutics

Phase 2/3

650

Bologna, Cagliari, Florence, Milan, Naples, Padova, Palermo, Pavia

2025-01-28

Recruiting

The Effects of Body Scan on Enteroception in Patients With Heart Failure

NCT06737679Heart Failure

Centro Cardiologico Monzino

Not applicable

110

Milan

2025-01-28

Recruiting

Landiolol in Mitral Valve Surgery

NCT06793670Cardiac Failure, Low Cardiac Output Syndrome

DrugLandiolol

Università Vita-Salute San Raffaele

Phase 4

1,500

Alessandria, Torino, Catania, Florence, Foggia, Genova, Milan, Palermo

2025-01-28

Recruiting

Prospective Multicenter Registry of Gender, Diversity and Inclusion (GEDI) of Women With Acute Coronary Syndrome

NCT06441942Acute Coronary Syndrome, Gender, Genetic Predisposition

IRCCS San Raffaele

Observational

100

Milan, Naples

2025-01-28

Recruiting

SIMPLIFication of Care Pathways for Patients With Rare Brain Tumors Through Artificial Intelligence

NCT06878469Brain Tumors

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Not applicable

200

Milan, L’Aquila

2025-01-27

Recruiting

Renin-guided Hemodynamic Management in Patients With Shock

NCT05898126Shock

Università Vita-Salute San Raffaele

Not applicable

800

Catanzaro, Milan

2025-01-27

Active, closed

A Study Assessing Adverse Event and How Oral ABBV-453 Moves Through the Body in Adult Participants With Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

NCT06291220Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugsABBV-453·Obinutuzumab

AbbVie

Phase 1

Milan, Bologna, Perugia

2025-01-27

Recruiting

Focused Ultrasound Unilateral Pallidotomy for Medication-Refractory Limb Dystonia

NCT07168850Limb Dystonia, Idiopathic Dystonia, Medication-refractory Dystonia, Dystonia, Focal

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Not applicable

Mestre, Messina, Milan, Palermo

2025-01-27

Recruiting

A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia

NCT06767683Narcolepsy Type 1, Narcolepsy Type 2, Idiopathic Hypersomnia

DrugALKS 2680

Alkermes, Inc.

Phase 2/3

786

Bologna, Milan, Verona

2025-01-27

Recruiting

Technological and Patient-tailored Innovations for Maximizing Effectiveness of Cardiac Arrest Resuscitation

NCT06538155Out-Of-Hospital Cardiac Arrest, Cardiac Arrest

Università Vita-Salute San Raffaele

Observational

500

Milan, Naples

2025-01-27

Recruiting

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

NCT06717347Diffuse Large B-Cell Lymphoma

DrugsRituximab Biosimilar·Zilovertamab vedotin·Riabni·Ruxience

Merck Sharp & Dohme LLC

Phase 3

1,046

Monza, Rionero in Vulture, Palermo, Candiolo, Ancona, Brescia, Milan, Novara

2025-01-27

Recruiting

Saliva and Extracellular Vesicles for Neurodegenerative Diseases

NCT06869135Neurodegenerative Diseases, Parkinson Disease, Alzheimer Disease, Parkinsonism

Fondazione Don Carlo Gnocchi ETS

Observational

242

Florence, Milan, Parma

2025-01-24

Recruiting

Novel Risk Prediction Approaches for the Primary Prevention of Cardiovascular Diseases in Italy: the CVRISK-IT Trial (CVRISK-IT)

NCT06832644Cardiovascular Risk, Genetic Cardiovascular Risk

IRCCS Policlinico S. Donato

Not applicable

30,000

Milan, Ancona, Genova, Naples, Palermo, Pavia, Pozzilli, Rome

2025-01-22

Recruiting

A New Tool to Promote Patient's Engagement in Their Healthcare Process

NCT06762496Breast Carcinoma, Breast Cancer Stage I, Breast Cancer Stage II

European Institute of Oncology

Observational

180

Milan

2025-01-22

Recruiting

A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease

NCT06100289Ulcerative Colitis, Crohn's Disease

DrugVedolizumab

Takeda

Phase 3

Messina, Milan, Pescara, Rome

2025-01-22

Recruiting

A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

NCT06585774Chronic Graft-versus-host-disease

DrugsAxatilimab·Methylprednisolone·Prednisolone·Prednisone

Incyte Corporation

Phase 3

240

Alessandria, Ancona, Bari, Brescia, Catania, Genova, Milan, Naples

2025-01-21

Not yet open

Occult Hepatitis B Virus Infection and HBV Reactivation After Switching to Long Acting Therapy in Patients With HIV-1

NCT06728917HBV (Hepatitis B Virus), HIV Infection

IRCCS San Raffaele

Observational

Bologna, Milan, Naples

2025-01-20

Active, closed

Pulmonary Complications Following TEVAR

NCT07863453Aortic Aneurysm and Dissection, Thoracic Endovascular Aortic Repair

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Observational

385

Milan, Varese

2025-01-20

Recruiting

A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

NCT06680830Parkinson Disease, Parkinson, Idiopathic Parkinson Disease, Early Parkinson Disease (Early PD)

Neuron23 Inc.

Phase 2

150

Milan, Naples, Padua, Pisa, Rome

2025-01-17

Recruiting

A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)

NCT06555419Muscular Atrophy, Spinal

DrugNusinersen

Biogen

Phase 1

Milan, Roma

2025-01-16

Recruiting

In Vivo Antibiotics Removal During Hemoadsorption Cartridges and Continuous Renal Replacement Therapy in the Intensive Care Unit

NCT07230041Septic Shock

Niguarda Hospital

Observational

Milan

2025-01-15

Active, closed

Comparison Between ABP 692 and Ocrevus® (Ocrelizumab)

NCT06700343Relapsing-remitting Multiple Sclerosis (RRMS)

DrugOcrelizumab

Amgen

Phase 3

152

Bologna, Milan, Naples, Rome

2025-01-13

Recruiting

MIRAMACS, Multicenter Italian Study on RAdial Mechanically Assisted Circulatory Support

NCT07458074Heart Failure

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

400

Bergamo, Bologna, Genova, Milan, Padova, Palermo, Pavia, Roma

2025-01-10

Recruiting

A Phase 2 Efficacy and Safety Study of GAL-101, 2% Ophthalmic Solution in Non-foveal Geographic Atrophy Secondary to Non-neovascular AMD

NCT06659549Geographic Atrophy of the Macula

Galimedix Therapeutics Inc

Phase 2

110

Milan, Roma

2025-01-10

Recruiting

A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis

NCT06807424Arthritis, Psoriatic

DrugIcotrokinra

Janssen Research & Development, LLC

Phase 3

750

Ancona, Brescia, Catania, Milan, Naples, Pavia, Roma, Rozzano

2025-01-09

Recruiting

Proper Dietary Management, Follow-up, and Lactase Enzyme Supplementation for Lactose Intolerance

NCT06773650Lactose Intolerant, Lactose Malabsorption, Lactose Intolerance

European Institute of Oncology

Observational

385

Milan

2025-01-08

Recruiting

Educational Motivational Program on Sleep Apnea

NCT06668597Obstructive Sleep Apnea (OSA)

Fondazione Don Carlo Gnocchi ETS

Not applicable

Milan

2025-01-08

Recruiting

Sleep Disturbance in Subjects With Autism Spectrum Disorders (ASD) in Preschool Age (18-60 Months)

NCT07470138Autism Spectrum Disorder

IRCCS Eugenio Medea

Observational

200

Bosisio Parini, Milan

2025-01-08

Active, closed

Miniscrews Placement for Orthodontic Anchorage

NCT06635304Miniscrew Placement, Third Palatal Ruga

IRCCS San Raffaele

Observational

Milan

2025-01-07

Active, closed

Distinguishing Non-Specific Low Back Pain from Scoliosis-Related Pain Via Quality of Life Questionnaires

NCT06779240Idiopathic Scoliosis, Degenerative Scoliosis

Istituto Scientifico Italiano Colonna Vertebrale

Observational

225

Milan

2025-01-07

Active, closed

Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease

NCT06760637Breast Cancer

DrugsAtirmociclib·Abemaciclib·Ribociclib·Palbociclib

Pfizer

Phase 3

1,035

Bologna, Meldola(FC), Rome, Florence, Milan, Novara, Padova, Roma

2025-01-06

Active, closed

A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01)

NCT06660654Advanced Solid Tumor, Metastatic Solid Tumors

DrugR-DXd

Daiichi Sankyo

Phase 2

335

Catania, Genova, Meldola, Milan, Naples, Terni

2025-01-06

Recruiting

Integration of Multiomics Markers for Invasive IPMNs Identification Through the Set-up of the INvasive Cyst bIomarkers Detection (INCITE) Consortium

NCT06694792IPMN, Pancreatic

IRCCS San Raffaele

Observational

800

Milan

2025-01-03

Recruiting

A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

NCT06588478Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

DrugPirtobrutinib

Loxo Oncology, Inc.

Phase 2

249

Bari, Cona, Florence, Milan, Novara, Padova, Palermo, Perugia

2025-01-03

Recruiting

A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

NCT06227910Crohn's Disease

DrugsVedolizumab·Upadacitinib

Takeda

Phase 3

396

Milan, Naples, Roma, Rozzano, San Giovanni Rotondo, Torino

2025-01-02

Recruiting

Pharmacokinetics and Safety of Givinostat in DMD Patients Ages From at Least 2 Years to Less Then 6 Years Old

NCT06769633Duchenne Muscular Dystrophy

Italfarmaco

Phase 2

Milan, Roma

2025-01-02

Not yet open

The Impact of Attentive System on Sleep Reactivity

NCT06694818Insomnia Due to Anxiety and Fear

IRCCS San Raffaele

Not applicable

Milan

2025-01-01

Recruiting

Extracellular Vesicles and Chemotherapy-Induced Peripheral Neuropathy

NCT07558447Chemotherapy-Induced Peripheral Neuropathy, Breast Cancer, Gastrointestinal Cancer, Lung Cancer

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Not applicable

120

Milan

2025-01-01

Recruiting

Microplastics and Nanoplastics in Patients With Chronic Coronary Syndromes

NCT07291609Chronic Coronary Syndrome, Microplastics, Nanoplastics, Coronary Artery Disease

Azienda Ospedaliera "Sant'Andrea"

Observational

120

Caserta, Forlì, Milan, Naples, Roma, Verona

2025-01-01

Not yet open

Diagnostic Performance of [11C]Choline PET/CT In the Preoperative Assessment of Primary Hyperparathyroidism

NCT06647966Primary Hyperparathyroidism

IRCCS San Raffaele

Observational

200

Milan

2025-01

Not yet open

Baricitinib in CPPD - the BAPTIST Study

NCT06768294Calcium Pyrophosphate Deposition Disease, Chondrocalcinosis

DrugsHydroxychloroquine·Baricitinib·Colchicine·Methylprednisolone

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Phase 2

Milan

2025-01

Active, closed

A Study to Test Long-term Treatment With Brigimadlin in People With Solid Tumours Who Took Part in a Previous Study With This Medicine

NCT06619509Solid Tumours

Boehringer Ingelheim

Phase 2

Milan, Padova

2024-12-30

Recruiting

A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma

NCT06600321Advanced Hepatocellular Carcinoma, Metastatic Hepatocellular Carcinoma

DrugsKeytruda·Pembrolizumab

Alnylam Pharmaceuticals

Phase 1

158

Milan, Rozzano, Verona

2024-12-30

Recruiting

Early Transcatheter Mitral Valve Repair After Myocardial Infarction

NCT06282042Acute Mitral Regurgitation

Fundación para la Investigación Biosanitaria del Principado de Asturias

Not applicable

250

Brescia, Genova, Milan, San Donato Milanese

2024-12-24

Recruiting

ECD-Score: a Study on Erdheim-Chester Disease

NCT07454343Erdheim-Chester Disease (ECD)

Meyer Children's Hospital IRCCS

Observational

1,000

Florence, Milan

2024-12-23

Recruiting

Size Up Bicuspid With the LIra MEthod: the SUBLIME Study

NCT06657911Bicuspid Aortic Valve (BAV)

IRCCS San Raffaele

Observational

250

Brescia, Milan, Roma

2024-12-21

Recruiting

Integrated Testing Strategy for Simultaneous Detection of ESR-1 and gBRCA Mutations Via Liquid Biopsy in HR+/HER2- Metastatic Breast Cancer (mBC) Patients,

NCT06762483Breast Cancer, Metastatic

European Institute of Oncology

Observational

Milan

2024-12-20

Recruiting

Prehabilitation to Improve Heart Rate Variability (PRIME)

NCT06744413Cancer Surgery

Università Vita-Salute San Raffaele

Not applicable

600

Catania, Foggia, Milan, Pisa

2024-12-20

Recruiting

Implementation of a New Algorithm for HRR Gene Mutation Testing in Patients With mPC Through Liquid Biopsy Integration

NCT06762379Metastatic Prostate Cancer (mPC)

European Institute of Oncology

Observational

125

Milan

2024-12-20

Active, closed

Observational Study to Characterize Patients Experiencing Major Acute Bleeding Events During Anticoagulation Treatment With Oral Factor Xa Inhibitors.

NCT07745933Major Bleeding, Major Bleeding Outcomes

Fadoi Foundation, Italy

Observational

503

Milan

2024-12-19

Active, closed

A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa Prophylaxis

NCT06752850Haemophilia A (Moderate or Severe), Hemophilia, Classic, Haemophilia, Hemophilia

DrugEfanesoctocog alfa

Swedish Orphan Biovitrum

Phase 4

Milan, Naples, Rozzano

2024-12-19

Recruiting

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

NCT06736574Heart Failure, Heart Failure With Reduced Ejection Fraction

Cytokinetics

Phase 3

1,800

Brescia, Rimini, Arzignano, Bergamo, Milan, Sesto San Giovanni, Perugia, Cona

2024-12-19

Active, closed

A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy

NCT06742190Multifocal Motor Neuropathy (MMN), MMN

DrugsEmpasiprubart·Immunoglobulin·IVIG

argenx

Phase 3

154

Florence, Genova, Gussago, Messina, Milan, Roma, Rozzano

2024-12-18

Recruiting

A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

NCT06727604Graves' Disease

DrugIMVT-1402

Immunovant Sciences GmbH

Phase 2

240

Bologna, Cagliari, Genova, Milan, Naples, Pisa, Roma, Siena

2024-12-17

Active, closed

Phase 2 Study of Rapcabtagene Autoleucel in Myositis

NCT06665256Idiopathic Inflammatory Myopathies

DrugRapcabtagene autoleucel

Novartis Pharmaceuticals

Phase 2

Ancona, Brescia, Monza, Milan, Rozzano, Verona

2024-12-17

Recruiting

Study on Disease Characteristics and Treatment in Locally Advanced or Recurrent / Metastatic Cervical Cancer in Italy

NCT06771193Cervical Cancer, Locally Advanced Cervical Cancer, Recurrent Cervical Cancer, Metastatic Cervical Cancer

MSD Italia S.r.l.

Observational

200

Bologna, Catania, Genova, Milan, Modena, Naples, Aviano, Roma

2024-12-17

Active, closed

Multidimensional Assessment of Fatigability in Older Adults Living in Southern Switzerland and Elderly With Parkinson's Disease

NCT07485218PARKINSON DISEASE (Disorder), Aged 65 Years or Older

University of Applied Sciences and Arts of Southern Switzerland

Observational

120

Milan

2024-12-17

Active, closed

Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2

NCT06672445Spinocerebellar Ataxia Type 2

Arrowhead Pharmaceuticals

Phase 1

Milan

2024-12-17

Recruiting

A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors

NCT06747585Squamous Non-small-cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Cervical Squamous Cell Carcinoma, Esophageal Squamous Cell Carcinoma

Alentis Therapeutics AG

Phase 1/2

170

Milan, Ravenna, Roma, Verona

2024-12-16

Active, closed

Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

NCT06608927Metastatic Pancreatic Ductal Adenocarcinoma

DrugsQuemliclustat·Nab-paclitaxel·Gemcitabine

Arcus Biosciences, Inc.

Phase 3

610

Bologna, Cremona, Florence, Milan, Modena, Padova, Piacenza, Roma

2024-12-13

Active, closed

Open-label, Multi-center, Phase I/II Study to Assess Safety, Disease Progression and Cellular Kinetics Following YTB323 Administration in Participants With Non-active Progressive Multiple Sclerosis (PMS)

NCT06675864Progressive Multiple Sclerosis

DrugRapcabtagene autoleucel

Novartis Pharmaceuticals

Phase 1/2

Genova, Milan

2024-12-12

Recruiting

A Study to Learn More About the Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Ataxia Who Are Prescribed it by Their Own Doctors

NCT06623890Friedreich Ataxia

DrugsOmaveloxolone·Skyclarys

Biogen

Observational

300

Conegliano, Milan, Rome

2024-12-12

Recruiting

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

NCT06750094Colorectal Neoplasms

DrugsLeucovorin calcium/Levoleucovorin·Amivantamab·Erbitux·Avastin

Janssen Research & Development, LLC

Phase 3

700

Candiolo, Catania, Florence, Milan, Padova, Pisa, Rozzano, Udine

2024-12-12

Recruiting

REdo Transcatheter Aortic VALVE Implantation for the Management of Transcatheter Aortic Valve Failure

NCT06557798Aortic Valve Stenosis

The Leeds Teaching Hospitals NHS Trust

Observational

550

Brescia, Catania, Genova, Milan, Palermo, San Donato Milanese, Torino, Verona

2024-12-12

Recruiting

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

NCT05421858Candidemia, Candidiasis, Invasive

DrugsCaspofungin·Fosmanogepix·Fluconazole

Basilea Pharmaceutica

Phase 3

450

Cuneo, Genoa, Milan, Modena, Pavia, Pisa, Siena, Trieste

2024-12-11

Active, closed

Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

NCT06627179Retinitis Pigmentosa (RP), Usher Syndrome Type 2, Deaf Blind, Retinal Disease

Laboratoires Thea

Phase 2

Milan

2024-12-11

Active, closed

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

NCT06588855Moderately to Severely Active Ulcerative Colitis

DrugAfimkibart

Hoffmann-La Roche

Phase 3

350

Rome, Brescia, Milan, Monza MI, Rozzano (MI), Negrar

2024-12-11

Active, closed

Impact of Spinal Curves on Asymmetric Posture in Idiopathic Scoliosis

NCT06733623Adolescent Idiopathic Scoliosis (AIS), Juvenile Idiopathic Scoliosis

Istituto Scientifico Italiano Colonna Vertebrale

Observational

490

Milan

2024-12-10

Active, closed

A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Crohn's Disease.

NCT06637631Crohn's Disease

DrugBalinatunfib

Sanofi

Phase 2

260

Milan, Rozzano, Padua, Rome, Pisa

2024-12-10

Recruiting

Tumor-microenvironment Spatial Interaction to Identify Markers of Resistance to Therapy in HER2+ Breast Cancer Patients

NCT06518382HER2-positive Breast Cancer

Giampaolo Bianchini

Observational

Milan

2024-12-10

By invitation

Phase 1b Long-term Extension Trial of RAY121 in Immunological Diseases (RAINBOW-LTE Trial)

NCT06723106Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP), Behçet's Syndrome (BS), Dermatomyositis (DM)

DrugRAY121

Chugai Pharmaceutical

Phase 1

144

Meldola, Milan, Torino

2024-12-09

Recruiting

EARLY-COGN^3 - Smart Digital Solutions for EARLY Treatment of COGnitive Disability: a Neuropsychological, Neurophysiological and Neurobiological Perspective in Chronic Neurological Diseases - PNRR-MCNT2-2023-12377069

NCT06657274Mild Cognitive Impairment (MCI), Subjective Cognitive Complaints (SCCs), Parkinson Disease

IRCCS Centro San Giovanni di Dio Fatebenefratelli

Not applicable

Brescia, Messina, Milan

2024-12-09

Recruiting

Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia

NCT06597019Familial Hypercholesterolemia - Heterozygous

DrugInclisiran

Novartis Pharmaceuticals

Phase 3

Milan, Roma, Torino, Verona

2024-12-09

Active, closed

Phase 3 Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Participants With Progressive Metastatic Castration-Resistant Prostate Cancer (XALute)

NCT06691984Metastatic Castration-resistant Prostate Cancer

DrugsXaluritamig·Cabazitaxel·Abiraterone·Enzalutamide

Amgen

Phase 3

707

Foggia, Gallipoli, Genova, Milan, Orbassano, Trento

2024-12-09

Active, closed

A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies

NCT06645886Hematologic Malignancies, Adult

DrugsKQB198·Dasatinib

Kumquat Biosciences Inc.

Phase 1

Bologna, Rome, Milan

2024-12-09

Recruiting

Study to Assess Effectiveness and Safety of Zanubrutinib for Patients With Marginal Zone Lymphoma Treated in Italy Under the Named Patient Program (NPP)

NCT06823960Marginal Zone Lymphoma(MZL)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Observational

Alessandria, Bologna, Catania, Cosenza, Ferrara, Meldola, Milan, Padova

2024-12-09

Recruiting

Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i.

NCT06382948Advanced Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, ESR1 Gene Mutation

DrugsElacestrant·Everolimus

MedSIR

Phase 3

300

Bergamo, Cagliari, Florence, Genova, Livorno, Milan, Modena, Monza

2024-12-05

Recruiting

Cannabis Extract in Fibromyalgia Syndrome - the SUNRISE Study

NCT06747039Fibromyalgia (FM)

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Observational

Milan

2024-12-05

Recruiting

Outcomes of Low-Risk Endometrial Cancer With Isolated Tumor Cells in the Sentinel Lymph Nodes: A Prospective, Multicenter, Single-Arm Observational Study

NCT06689956FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma, FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma, Stage IA1 Endometrial Cancer FIGO 2023, Stage IA2 Endometrial Cancer FIGO 2023

Mayo Clinic

Observational

212

Verduno, Monza, Milan, Roma, Udine, Naples

2024-12-04

Active, closed

Nipocalimab in Moderate to Severe Sjogren's Disease

NCT06741969Sjogrens Syndrome

DrugNipocalimab

Janssen Research & Development, LLC

Phase 3

655

Milan, Palermo, Perugia, Pisa, Roma, Rozzano, Udine

2024-12-04

Recruiting

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

NCT06465953Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS), Myelodysplastic Syndromes (MDS)

DrugsIvosidenib·Azacitidine

Institut de Recherches Internationales Servier

Phase 3

Ancona, Bologna, Florence, Milan, Pavia, Roma, Torino

2024-12-03

Recruiting

Evaluation of the Variation Over Time of Visuospatial Deficit in Patients With Parietal Lobe Glioma

NCT07286929Glioma, Parietal Lobe Glioma, Visuspatial Deficit, Unilateral Spatial Neglect (USN)

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Observational

Milan

2024-12-03

Active, closed

A Trial of Amlenetug (Lu AF82422) in Participants With Multiple System Atrophy (MSA)

NCT06706622Multiple System Atrophy

DrugAmlenetug

H. Lundbeck A/S

Phase 3

401

Bologna, Milan, Naples, Pisa, Salerno

2024-12-03

By invitation

Outcomes of Empiric Antibiotic Therapy Based on Hospital Antibiograms in Organ Transplant Recipients with Bacteraemia

NCT06874920Bacteremia, Transplant Recipient

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Observational

150

Milan

2024-12-03

Not yet open

Bladder Preservation With Sacituzumab Govitecan + Zimberelimab for Muscle-Invasive Bladder Cancer

NCT06528483Bladder Cancer, Bladder Urothelial Carcinoma, Bladder Neoplasm, Muscle-Invasive Bladder Carcinoma

DrugsZimberelimab·Sacituzumab Govitecan

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Phase 2

Milan

2024-12-02

Recruiting

A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease

NCT06717698Chronic Kidney Disease

DrugSemaglutide

Novo Nordisk A/S

Phase 2

465

L’Aquila, Chieti, Bologna, Bergamo, Brescia, Milan, Pisa, Roma

2024-12-02

Active, closed

Antiviral Long Acting Drugs Landing in People Living With HIV

NCT06468995HIV, Antiviral Agents

IRCCS San Raffaele

Not applicable

120

Milan

2024-12-02

Recruiting

Robotic vs. Traditional Verticalization in Patients With Severe Acquired Brain Injury: a Randomized Controlled Trial

NCT06469983Acquired Brain Injury, Disorder of Consciousness

Anna Estraneo

Not applicable

118

Sant'Angelo dei Lombardi, Bari, Telese Terme, Genova, Milan, Pavia

2024-12-02

Recruiting

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

NCT06667700Coronavirus Disease (COVID-19)

DrugMolnupiravir

Merck Sharp & Dohme LLC

Phase 3

3,082

Bologna, Genova, Milan, Pisa

2024-12-02

Active, closed

A Study to Evaluate the Effectiveness of Long-acting (LA) Cabotegravir (CAB) + Rilpivirine (RPV) LA When Given to Participants With Detectable HIV-1

NCT06694805HIV Infections

DrugsRpv La·B/F/TAF·Cabotegravir

ViiV Healthcare

Phase 3

326

Bari, Bergamo, Milan, Roma

2024-12-02

Not yet open

Pentabiocel in Pediatric IBS

NCT06720805Irritable Bowel Syndrome (IBS), Pediatrics

University of Roma La Sapienza

Not applicable

Milan, Rome

2024-12-01

Recruiting

Pilot Italian Cardiogenic Shock Initiative

NCT06475456Cardiogenic Shock

Fondazione GISE Onlus

Observational

786

Chivasso, Cirié, Desio, Ivrea, Milan, Moncalieri, Rho, Savigliano

2024-12-01

Active, closed

Evaluation of Effectiveness of the LifeSkills Training - Lombardia - Primary Shool Program ( Val3P-LST )

NCT07858513Well Being, Drug Addiction, Tobacco Use, Alcohol Abuse

Agenzia di Tutela della Salute della Città Metropolitana di Milano

Not applicable

3,927

Milan

2024-12-01

Recruiting

A Heart Rate Variability (HRV) Biofeedback Training in Functional Gastrointestinal Disorders (FGID)

NCT06687057Functional Gastrointestinal Disorders (FGIDs)

Fondazione Don Carlo Gnocchi ETS

Not applicable

Milan

2024-12-01

Cite this view

Priya Life Science (2026). Clinical trial register: studies with an Italian investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 11 October 2026. https://priyalifescience.com/clinical-trials-italy/city/milan?page=2

Query this register directly

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Italy and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,791 studies in total at the last sync on 11 Oct 2026, 03:19 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 2,846 of those studies with a site in Milan.

How many clinical trials are recruiting in Milan?

1,595 of the 2,846 studies on this page are recruiting new participants as of the 11 Oct 2026, 03:19 UTC sync. A further 145 have not yet opened recruitment, 1,033 are active but closed to new participants, and 73 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.